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TCN2 Gene

protein-coding GIFtS: 59

GC22P029327

transcobalamin II; macrocytic anemia
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
D22S676 ^¹, ²
D22S750 ^¹, ²
TC-2 ^³
TC2 ^¹, ², ³, ⁵
TCII ^³

Descriptions
TC II ^³
Transcobalamin II ^², ³
transcobalamin II; macrocytic anemia ^²

External Ids
HGNC: 11653¹
Entrez Gene: 6948²
UniProtKB: P20062³
Ensembl: ENSG00000185339⁷

Search outside databases for aliases for TCN2 gene

Previous GC identifer: GC22P027699

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TCN2:

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins,

alternatively referred to as R binders, is expressed in various tissues and secretions. This

plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein

and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic

factor, may have evolved by duplication of a common ancestral gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: TCO2_HUMAN, P20062

Function: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TCN2 gene

Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.2

TCN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P029327: (about GC identifiers)

Start:	29,333,139 bp from pter
End:	29,353,047 bp from pter
Size:	19,909 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TCO2_HUMAN, P20062 (See protein sequence)

Recommended Name: Transcobalamin-2 precursor

Size: 427 amino acids; 47535 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

2BB5 (3D)

Secondary accessions: Q9BVI8 Q9UCI5 Q9UCI6 Q9UDM0

REFSEQ proteins: NP_000346.2

ENSEMBL proteins:

ENSP00000385914 ENSP00000384914 ENSP00000215838

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TCN2)
	Human Recombinant Proteins from Abnova (TCN2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	1708393

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Antibodies for TCN2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TCN2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (TCN2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TCN2)
	Novus Biologicals Antibody for TCN2

Assays for TCN2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P20062

ProtoNet protein and cluster: P20062

1 Blocks protein family: IPB002157 Eukaryotic cobalamin-binding protein

UniProtKB/Swiss-Prot: TCO2_HUMAN, P20062

Similarity: Belongs to the eukaryotic cobalamin transport proteins family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TCN2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TCN2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000355

Applied Biosystems Silencer® siRNAs for TCN2

Sigma-Aldrich siRNA and siRNA Panels for TCN2

Sigma-Aldrich shRNA for TCN2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TCN2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000355
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000355
untagged cDNA clones in CMV expression vector (see all 2): NM_000355

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000355

UniProtKB/Swiss-Prot: TCO2_HUMAN, P20062

Function: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells

Genatlas biochemistry entry for TCN2:

transcobalamin II,plasma protein vitamin B12 binding

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015087	cobalt ion transmembrane transporter activity	IEA	--
GO:0031419	cobalamin binding	IEA	--
GO:0050897	cobalt ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for TCN2

5/11 Interacting proteins for TCN2 (ENSP00000215838³) via UniProtKB, MINT, and/or STRING (see all 11 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MTR	ENSP00000355535³	STRING (score=.916)
LRP2	ENSP00000263816³	STRING (score=.889)
CDAN1	ENSP00000348564³	STRING (score=.859)
MTHFR	ENSP00000365767³	STRING (score=.847)
MTRR	ENSP00000264668³	STRING (score=.838)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006824	cobalt ion transport	IEA	--
GO:0015889	cobalamin transport	TAS	3782074

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TCN2
5 Novoseek chemical compound relationships for TCN2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
homocysteine	74.11	16	9176833 (5), 17220211 (1), 15086930 (1), 12911562 (1) (see all 9)
methylmalonic acid	73.99	1	8626762 (1)
corrinoid	71.21	1	9095356 (1)
methionine	67.74	13	2070814 (1), 9587028 (1), 17164363 (1), 17449906 (1) (see all 11)
cystathionine	61.04	3	16412818 (1), 14752013 (1), 18799873 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TCN2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TCN2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000355

Sigma-Aldrich siRNA and siRNA Panels for TCN2

Sigma-Aldrich shRNA for TCN2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000355

REFSEQ mRNAs for TCN2 gene:

NM_000355.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000355

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000355
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000355
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000355

Additional cDNA sequence:

AK225445.1 AK313711.1 BC001176.1 BC011239.1 CR456591.1 CR590469.1 CR604069.1 CR607717.1

L02647.1 L02648.1 M60396.1

8 DOTS entries:

DT.451827 DT.40129095 DT.75136777 DT.91829780 DT.100764218 DT.100769826 DT.100738154 DT.75120205

24/180 AceView cDNA sequences (see all 180 ):

BU185449 NM_000355 CD672244 CR590469 BM708955 AI570511 AU122683 BU196466

BC001176 BX345241 AL040870 BC011239 BQ679837 BE855856 CR604069 BI916813

BX395297 AV708225 CR607717 BM977935 CR456591 BQ881415 BP346761 BF439265

highest scoring ESTs for TCN2:

L02648 AA069209 AA196511 AA205596 AA453855 AA490459 AA612821 AA862710 AA902116 AA936072

Unigene Cluster for TCN2:

Transcobalamin II; macrocytic anemia

Hs.417948 [show with all ESTs]

Unigene Representative Sequence: AK225445

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TCN2

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9
SP1:
SP2:									-

About this scheme

ECgene alternative splicing isoforms for TCN2

3 Ensembl transcripts including schematic representations:

ENST00000405742 ENST00000407817 ENST00000215838

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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TCN2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TCN2

¹ / ² / ³

4 probe-sets matching TCN2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37922_at²^{, 3}	U95-A	1	0.88	1.00	0.92	0.88	L02648	1.00	1.00	1.00	1
89946_at²^{, 3}	U95-D	2	0.62	0.95	0.97	1.12	AA620916	0.60	1.00	0.82	1
204043_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000355	0.60	1.00	0.82	1
204043_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TCN2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGCATCTCA

SOURCE GeneReport for Unigene cluster: Hs.417948
Expression variation in blood from EXPOLDB for TCN2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TCN2 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TCN2¹	--	transcobalamin II; macrocytic anemia	82.51(n) 76.35(a)	486355 XM_543481.2 XP_543481.2
chimpanzee (Pan troglodytes)	TCN2¹	--	transcobalamin II; macrocytic anemia	98.91(n) 98.13(a)	470178 XM_525562.2 XP_525562.1
cow (Bos taurus)	TCN2¹	--	transcobalamin II; macrocytic anemia	79.31(n) 73.07(a)	281518 NM_174195.3 NP_776620.2
rat (Rattus norvegicus)	Tcn2¹	--	transcobalamin 2	78.12(n) 74.64(a)	64365 NM_022534.1 NP_071979.1
mouse (Mus musculus)	Tcn2^{1, 5}	11 (3.00 cM)⁵	transcobalamin 2^{1, 5}	78.06(n)¹ 73.54(a)¹	21452¹ NM_015749.2¹ NP_056564.1¹ AF090686⁵ AK133707⁵ (see all 25)

About this table Species with no ortholog for TCN2

ENSEMBL Gene Tree for TCN2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TCN2 gene

TCN1² GIF²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: TCO2_HUMAN, P20062

Polymorphism: Pro/Arg-259 polymorphism affects TCN2 plasma concentration and may interfere in

vitamin B(12) cellular availability and homocysteine metabolism

10/286 NCBI SNPs in TCN2 are shown (see all 286 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 97)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1544468^1,2	A,C,F,H,O	29353191(+)	`ATGACA/GTTGAC`	1	--	ng3¹		11	MN EU EA WA NA	1012
	rs4820889^1,2	A,C,F,H	29349044(+)	`TCTCCG/AAGACC`	1	Q/R	mis¹		8	EU EA WA	836
	rs5753231^1,2	A,C,F,H	29333069(+)	`GTTCCC/TTACCT`	1	--	ng5¹ tfbs³		8	EU EA WA	838
	rs1801198^1,2	A,C,F,H	29341610(+)	`CATGCC/GTGGGG`	1	R/P	mis¹ ese³		9	EA MN EU WA NA	2320
	rs10418^1,2	A,C,F,H	29352952(+)	`AGCTCC/TGAGCT`	1	--	ut3¹		8	EA MN EU WA NA	2278
	rs5749131^1,2	A,C,F,H	29331822(+)	`GATAAG/ATCAGG`	1	--	ng5¹ tfbs³		8	EU EA WA	838
	rs9606756^1,2	C,F,H	29336860(+)	`AAGAAA/GTACCA`	1	I/V	mis¹		12	NA EU EA WA	1056
	rs2072195^1,2	C,F,H	29352733(+)	`GGCCAA/TGTCTG`	1	--	ut3¹ ese³		5	EA EU WA	1886
	rs9621049^1,2	C,F,H	29343419(+)	`CATCTC/TTGTTC`	1	S/F	mis¹ ese³		13	EU EA WA NA	1336
	rs2240433^1,2	A,C,F	29333138(+)	`CACAGA/GCCTTC`	1	--	ng5¹		1	EA	1498

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HapMap Linkage Disequilibrium images for TCN2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 275350

UniProtKB/Swiss-Prot: TCO2_HUMAN, P20062

Defects in TCN2 are the cause of transcobalamin II deficiency [MIM:275350]. This results

in various forms of anemia

10/21 Novoseek disease relationships for TCN2 gene (see all 21 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
transcobalamin ii deficiency	97.74	18	8362900 (3), 7741573 (2), 17993636 (2), 7980584 (1) (see all 14)
anemia megaloblastic	83.46	8	8978297 (1), 2333586 (1), 7742531 (1), 12436132 (1) (see all 7)
methylmalonic aciduria	70.99	3	1909779 (1), 2309761 (1), 10518276 (1)
vitamin b12 deficiency	62.23	2	7849710 (1)
neural tube defects	56.04	2	15782407 (1), 11259691 (1)
homocystinuria	54.48	1	2309761 (1)
hemoglobinuria	53.70	6	7622977 (4), 8708525 (1)
typhus	52.45	2	7622977 (1), 15906652 (1)
malaria cerebral	44.47	1	7759977 (1)
azotemia	39.06	5	7673805 (1), 8525419 (1)

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Genatlas disease: TCN2

anemia,megalobastic,severe with thrombocytopenia and neutropenia,methylmalonic acidemia and

homocystinuria

Human Gene Mutation Database: TCN2
Genetic Association Database: TCN2
Human Genome Epidemiology Navigator: TCN2 (34 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/150 PubMed articles for TCN2 gene (see all 150 ):

The cDNA sequence and the deduced amino acid sequence of human transcobalamin II show homology with rat intrinsic factor and human transcobalamin I. (PubMed id 1708393)^{1, 2, 3, 4} Platica O....Rothenberg S.P. (1991)
The cloning and characterization of the human transcobalamin II gene. (PubMed id 7742531)^{1, 2, 3, 4} Regec A....Rothenberg S.P. (1995)
Functional human transcobalamin II isoproteins are secreted by insect cells using the baculovirus expression system. (PubMed id 8443384)^{1, 3, 4} Quadros E.V.... Rothenberg S.P. (1993)
Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population. (PubMed id 15782407)^{1, 3, 6} Swanson D.A....Brody L.C. (2005)
Folate-related genes and omphalocele. (PubMed id 15937947)^{1, 3, 6} Mills J.L....Brody L.C. (2005)
Population-based differences in frequency of the transcobalamin II Pro259Arg polymorphism. (PubMed id 14725943)^{1, 3, 6} Bowen R.A....Cole D.E. (2004)
Effects of TCN2 776C>G on vitamin B, folate, and total homocysteine levels in kidney transplant patients. (PubMed id 15086930)^{1, 3, 6} Winkelmayer W.C....Sunder-Plassmann G. (2004)
Isolation and sequence analysis of variant forms of human transcobalamin II. (PubMed id 8439564)^{1, 3, 4} Li N....Seetharam B. (1993)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{3, 4} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6948	HGNC: 11653	AceView: TCN2	Ensembl:ENSG00000185339	euGenes: HUgn6948
ECgene: TCN2	H-InvDB: TCN2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
TCN2base	http://bioinf.uta.fi/TCN2base/

Licensable Technologies for TCN2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for TCN2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TCN2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TCN2		Antibodies for TCN2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TCN2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TCN2)
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	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for TCN2

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Antibodies for TCN2

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TCN2 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for TCN2

Summaries
for TCN2

Genomic Location
for TCN2

Proteins
for TCN2

Protein Domains/
Families
for TCN2

Gene Function
for TCN2

Pathways & Interactions
for TCN2

Drugs & Compounds
for TCN2

Transcripts
for TCN2

Expression
for TCN2

Orthologs
for TCN2

Paralogs
for TCN2

SNPs/Variants
for TCN2

Disorders & Mutations
for TCN2

Medical News
for TCN2

Publications
for TCN2

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Genome Databases showing TCN2

Other Databases showing TCN2

Specialized Databases showing TCN2

Licensable Technologies
for TCN2

Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TCN2 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor TCN2

Summariesfor TCN2

Genomic Locationfor TCN2

Proteinsfor TCN2

Protein Domains/Familiesfor TCN2

Gene Functionfor TCN2

Pathways & Interactionsfor TCN2

Drugs & Compoundsfor TCN2

Transcriptsfor TCN2

Expression for TCN2

Orthologsfor TCN2

Paralogsfor TCN2

SNPs/Variantsfor TCN2

Disorders & Mutationsfor TCN2

Medical Newsfor TCN2

Publicationsfor TCN2

Search for TCN2

Genome Databases showing TCN2

Other Databases showing TCN2

Specialized Databases showing TCN2

Licensable Technologiesfor TCN2

Servicesfor TCN2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TCN2

Summaries
for TCN2

Genomic Location
for TCN2

Proteins
for TCN2

Protein Domains/
Families
for TCN2

Gene Function
for TCN2

Pathways & Interactions
for TCN2

Drugs & Compounds
for TCN2

Transcripts
for TCN2

Expression
for TCN2

Orthologs
for TCN2

Paralogs
for TCN2

SNPs/Variants
for TCN2

Disorders & Mutations
for TCN2

Medical News
for TCN2

Publications
for TCN2

Licensable Technologies
for TCN2

Services
for TCN2