TCN1 Gene
protein-coding GIFtS: 56
GCID: GC11M059620
|
|
transcobalamin I (vitamin B12 binding protein, R binder...
| |
Aliases
for TCN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transcobalamin I (Vitamin B12 Binding Protein, R Binder Family)1 2 | | Haptocorrin1 | | TC11 2 3 5 | | Transcobalamin-11 | | TCI1 2 3 | | TC I3 | | TC-12 3 | | Transcobalamin I3 | | Haptocorin1 | | |
Export aliases for TCN1 gene to outside databasesPrevious GC identifers: GC11M062014 GC11M061133 GC11M059871 GC11M059395 GC11M059376 GC11M055967 |
Summaries
for TCN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TCN1:
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referredto as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondarygranules in neutrophils and facilitates the transport of cobalamin into cells. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TCO1_HUMAN, P20061Function: Vitamin B12-binding protein. Transports cobalamin into cells
Gene Wiki entry for TCN1 (Haptocorrin)
|
Genomic Views
for TCN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TCN1 gene promoter:
Brachyury FOXD3 CUTL1 NF-kappaB NF-kappaB1 POU3F2 TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q11-q12 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q11-q12TCN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M059620: view genomic region
(about GC identifiers)
Start:
|
59,620,273 bp from pter |
End:
|
59,634,048 bp from pter |
Size:
|
13,776 bases |
Orientation:
|
minus strand |
|
Proteins
for TCN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TCO1_HUMAN, P20061 (See
protein sequence)Recommended Name: Transcobalamin-1 precursor Size: 433 amino acids; 48207 Da
Subcellular location: Secreted
1 PDB 3D structure from  and Proteopedia  for TCN1:2CKV (3D)
Secondary accessions: A8KAC5 Q8WV77Explore the universe of human proteins at neXtProt for TCN1: NX_P20061
Post-translational modifications:
Contains about 30% carbohydrates1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P20061
TCN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001053.2
ENSEMBL proteins: ENSP00000257264
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
TCN1 for ontologies About GeneDecksing
TCN1 Antibody Products:
Assay Products for TCN1: |
Protein
Domains /
Families
for TCN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCN1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P20061ProtoNet protein and cluster: P20061 1 Blocks protein family: IPB002157 Eukaryotic cobalamin-binding protein
UniProtKB/Swiss-Prot: TCO1_HUMAN, P20061Similarity: Belongs to the eukaryotic cobalamin transport proteins family |
Function
for TCN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TCO1_HUMAN, P20061Function: Vitamin B12-binding protein. Transports cobalamin into cells Genatlas biochemistry entry for TCN1:transcobalamin 1 (vitamin B12 binding protein,R binder family),in secondary granules of mature neutrophils
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCN1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031419 | cobalamin binding |
IBA | -- |
TCN1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TCN1:
|
Pathways & Interactions
for TCN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCN1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TCN1 (ENSP000002572644) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006824 | cobalt ion transport |
IEA | -- | | GO:0009235 | cobalamin metabolic process |
IBA | -- | | GO:0015889 | cobalamin transport |
IEA | -- |
TCN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TCN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TCN1 for compounds About GeneDecksing
 Browse Tocris compounds for TCN1
3 HMDB Compounds for TCN1 About this table
2 DrugBank Compounds for TCN1 About this table
9 Novoseek chemical compound relationships for TCN1 gene About this table
Search CenterWatch for drugs/clinical trials and news about TCN1 / TCO1
|
Transcripts
for TCN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCN1 gene: NM_001062.3 Unigene Cluster for TCN1: Transcobalamin I (vitamin B12 binding protein, R binder family) Hs.2012 [show with all ESTs]Unigene Representative Sequence: NM_0010625 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000529251 ENST00000257264(uc001noj.2) ENST00000532419 ENST00000534531
ENST00000533734
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AK292990.1 BC018632.1 J05068.1 4 DOTS entries: DT.411203 DT.102821453 DT.91709439 DT.99957312 24/71 AceView cDNA sequences (see all 71): BM769693 BM769239 BM830954 CB123040 BM830340 AA155640 BM769834 BQ084191 CD723971 BX281344 NM_001062 BU675098 AW192630 AA347734 CB048956 BP370727 BU689883 BF102528 BC018632 AW604102 AA372040 BE005813 BX480228 J05068
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TCN1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for TCN1
|
Expression
for TCN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TCN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCN1
SOURCE GeneReport for Unigene cluster: Hs.2012
UniProtKB/Swiss-Prot: TCO1_HUMAN, P20061Tissue specificity: Neutrophil granule protein
SABiosciences Custom PCR Arrays for TCN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCN1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCN1 |
Orthologs
for TCN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TCN1 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TCN16 |
-- |
47(a) |
1 ↔ 1 |
1(90850658-90858733) |
ENSEMBL Gene Tree for TCN1 (if available)
TreeFam Gene Tree for TCN1 (if available) |
Paralogs
for TCN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TCN1 gene
- GIF2 TCN22
1 SIMAP similar gene for TCN1 using alignment to 1 protein entry: TCO1_HUMAN:GIF
TCN1 for paralogs About GeneDecksing
|
Genomic Variants
for TCN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TCN1 (59620273 - 59634048 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TCN1
1 CNV: 38238
Human Gene Mutation Database (HGMD): TCN1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCN1 |
|
Disorders
/ Diseases
for TCN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCN1 for disorders About GeneDecksing
OMIM gene information: 189905
OMIM disorders: --
20/35  diseases for TCN1 (see all 35): About MalaCardsdiffuse large b-cell lymphoma neural tube defect b-cell lymphomas non-hodgkin lymphoma
pernicious anemia spontaneous abortion megaloblastic anemia cleft lip
cleft palate hodgkin's lymphoma rheumatoid arthritis myeloproliferative disorder
follicular lymphoma oral cancer anemia hyperhomocysteinemia
hepatocellular carcinoma down syndrome vascular disease crohn's disease
3 diseases from the University of Copenhagen DISEASES database for TCN1:Vitamin B12 deficiency Megaloblastic anemia Pernicious anemia 7 Novoseek disease relationships for TCN1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| vitamin b12 deficiency |
41.8 |
1 |
12356110 (1) |
| myeloid leukemia chronic |
29.2 |
1 |
8301203 (1) |
| oral cancer |
20.9 |
3 |
8820365 (2), 9587699 (1) |
| hepatocellular carcinoma |
0 |
1 |
10101589 (1) |
| rheumatoid arthritis |
0 |
3 |
1602292 (1), 2062181 (1) |
| anemia |
0 |
4 |
1602292 (1) |
| tumors |
0 |
1 |
18413759 (1) |
Genetic Association Database (GAD): TCN1
Human Genome Epidemiology (HuGE) Navigator: TCN1 (21 documents)
Export disorders for TCN1 gene to outside databases
|
Publications
for TCN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCN1 gene, integrated from 9 sources (see all 134):
(articles sorted by number of sources associating them with TCN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
- Transcobalamin 776C->G polymorphism negatively affects vitamin B-12 metabolism. (PubMed id 15941899)1, 4 von Castel-Dunwoody K.M....Bailey L.B. (2005)
- Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population. (PubMed id 16268464)1, 4 Gueant-Rodriguez R.M....Gueant J.L. (2005)
- Homocysteine and related genetic polymorphisms in Down's syndrome IQ. (PubMed id 15834031)1, 4 Gueant J.L....Romano C. (2005)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease. (PubMed id 14739547)1, 4 McCaddon A....Regland B. (2004)
- Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease. (PubMed id 15201366)1, 4 Bosco P....Gueant J.L. (2004)
- Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease. (PubMed id 15073531)1, 4 Anello G....Ferri R. (2004)
- The role of genetic factors in the development of hyperhomocysteinemia. (PubMed id 14656021)1, 4 Geisel J....Herrmann W. (2003)
- Gene-gene interaction between fetal MTHFR 677C>T and transcobalamin 776C>G polymorphisms in human spontaneous abortion. (PubMed id 12923155)1, 4 Zetterberg H....Blennow K. (2003)
|
External Searches for TCN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TCN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TCN1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TCN1 gene:
Search GeneIP for patents involving TCN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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