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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCN1 Gene

protein-coding   GIFtS: 60
GCID: GC11M059620

Transcobalamin I (Vitamin B12 Binding Protein, R Binder...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcobalamin I (Vitamin B12 Binding Protein, R Binder Family)1 2     TCI2 3
TC12 3 5     transcobalamin-12
haptocorin1 2     TC I3
haptocorrin1 2     Transcobalamin I3
TC-12 3     

External Ids:    HGNC: 116521   Entrez Gene: 69472   Ensembl: ENSG000001348277   OMIM: 1899055   UniProtKB: P200613   

Export aliases for TCN1 gene to outside databases

Previous GC identifers: GC11M062014 GC11M061133 GC11M059871 GC11M059395 GC11M059376 GC11M055967


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCN1 Gene:
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively
referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of
secondary granules in neutrophils and facilitates the transport of cobalamin into cells. (provided by RefSeq, Jul
2008)

GeneCards Summary for TCN1 Gene: 
TCN1 (transcobalamin I (vitamin B12 binding protein, R binder family)) is a protein-coding gene. Diseases associated with TCN1 include pernicious anemia, and oral cancer, and among its related super-pathways are Metabolism of water-soluble vitamins and cofactors and Metabolic pathways. GO annotations related to this gene include cobalamin binding. An important paralog of this gene is GIF.

UniProtKB/Swiss-Prot: TCO1_HUMAN, P20061
Function: Vitamin B12-binding protein. Transports cobalamin into cells

Gene Wiki entry for TCN1 (Haptocorrin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCN1 gene promoter:
         Brachyury   FOXD3   CUTL1   NF-kappaB   NF-kappaB1   POU3F2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TCN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11-q12   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q11-q12

TCN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCN1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M059620:  view genomic region     (about GC identifiers)

Start:
59,620,273 bp from pter      End:
59,634,048 bp from pter
Size:
13,776 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCO1_HUMAN, P20061 (See protein sequence)
Recommended Name: Transcobalamin-1 precursor  
Size: 433 amino acids; 48207 Da
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for TCN1:
2CKV (3D)    
Secondary accessions: A8KAC5 Q8WV77

Explore the universe of human proteins at neXtProt for TCN1: NX_P20061

Explore proteomics data for TCN1 at MOPED 

Post-translational modifications:

  • UniProtKB: Contains about 30% carbohydrates
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20061

  • TCN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCN1 Protein Expression
    REFSEQ proteins: NP_001053.2  
    ENSEMBL proteins: 
     ENSP00000257264  
    Reactome Protein details: P20061
    Human Recombinant Protein Products for TCN1: 
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    Novus Biologicals TCN1 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TCN1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    TCN1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002157 Cbl-bd_transpt_euk

    Graphical View of Domain Structure for InterPro Entry P20061

    ProtoNet protein and cluster: P20061

    1 Blocks protein domain: IPB002157 Eukaryotic cobalamin-binding protein

    UniProtKB/Swiss-Prot: TCO1_HUMAN, P20061
    Similarity: Belongs to the eukaryotic cobalamin transport proteins family


    TCN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCO1_HUMAN, P20061
    Function: Vitamin B12-binding protein. Transports cobalamin into cells

         Genatlas biochemistry entry for TCN1:
    transcobalamin 1 (vitamin B12 binding protein,R binder family),in secondary granules of mature neutrophils

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031419cobalamin binding IBA--
         
    TCN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TCN1:
     Cell cycle / mitosis defect 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TCN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TCN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCN1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TCN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors1.00
    Metabolism of vitamins and cofactors1.00
    2Metabolism
    Metabolism0.40
    3Cobalamin (Cbl, vitamin B12) transport and metabolism
    Cobalamin (Cbl, vitamin B12) transport and metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for TCN1
        Metabolism
    Cobalamin (Cbl, vitamin B12) transport and metabolism
    Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors



    TCN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCN1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TCN1 (ENSP000002572644) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLENSP000002640334STRING: ENSP00000264033
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006824cobalt ion transport IEA--
    GO:0009235cobalamin metabolic process TAS--
    GO:0015889cobalamin transport IEA--

    TCN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TCN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCN1 (TCO1)

    3 HMDB Compounds for TCN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cobalamin5,6-dimethyl-1-a-D-ribofuranosylbenzimidazole (see all 15)13408-78-1--
    CobaltCo (see all 6)7440-48-4--
    CyanocobalaminDimethylbenzimidazoylcobamide (see all 92)68-19-9--

    2 DrugBank Compounds for TCN1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CyanocobalaminCyanocob(III)alamin (see all 3)68-19-9transportersubstrate17259255 16047053
    HydroxocobalaminHydroxomin (see all 2)13422-51-0targetother6726060 844253

    9 Novoseek inferred chemical compound relationships for TCN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cobalamin 93.9 51 8988263 (2), 12881454 (2), 16384893 (2), 12356110 (1) (see all 32)
    vitamin b12 87.9 44 17990953 (2), 8689919 (2), 16613998 (2), 8172125 (2) (see all 25)
    cobinamide 87.1 1 11788601 (1)
    methylmalonic acid 81.4 1 17990953 (1)
    corrinoid 67.7 5 2070790 (3), 19299543 (1)
    methylcobalamin 56.3 1 7772517 (1)
    homocysteine 47.2 1 11259691 (1)
    cobalt 28.3 1 2070790 (1)
    methionine 13.2 1 16470748 (1)

    Search CenterWatch for drugs/clinical trials and news about TCN1 / TCO1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCN1 gene: 
    NM_001062.3  

    Unigene Cluster for TCN1:

    Transcobalamin I (vitamin B12 binding protein, R binder family)
    Hs.2012  [show with all ESTs]
    Unigene Representative Sequence: NM_001062
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529251 ENST00000257264(uc001noj.2) ENST00000532419 ENST00000534531
    ENST00000533734

    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCN1

    Additional mRNA sequence: 

    AK292990.1 BC018632.1 J05068.1 

    4 DOTS entries:

    DT.411203  DT.102821453  DT.91709439  DT.99957312 

    24/71 AceView cDNA sequences (see all 71):

    CD723971 AA155640 BM769693 BM830340 BU675098 BX281344 CB123040 BM769834 
    BQ084191 NM_001062 BM769239 BM830954 BG779234 AW192630 BF102528 AW604104 
    BI762019 AW604102 AW376461 AW337203 CB048957 CB959482 BP370727 BC018632 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TCN1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                                                        
    SP2:              -                                                         
    SP3:                                      -     -                           


    ECgene alternative splicing isoforms for TCN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCN1 expression in normal human tissues (normalized intensities)      TCN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TCN1 Expression
    About this image


    TCN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Epithelium
             Human Tracheal Epithelial Cells (HTEpiC)   
             breast epithelium   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Human Tracheal Epithelial Cells (HTEpiC)   
             Trachea   
     
     Breast (Uncategorized)    fully expand to see all 2 entries
             Human Mammary Epithelial Cells (HMEpiC)   
             breast epithelium   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Fetal Liver CD36+ Cells   
     
     Bone (Muscoskeletal System)
             Bone Marrow

    See TCN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCN1

    SOURCE GeneReport for Unigene cluster: Hs.2012

    UniProtKB/Swiss-Prot: TCO1_HUMAN, P20061
    Tissue specificity: Neutrophil granule protein

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TCN1 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia TCN11 transcobalamin I (vitamin B12 binding protein, R binder more 77.06(n)
    63.28(a)
      612538  XM_850268.1  XP_855361.1 
    lizard
    (Anolis carolinensis)
    Reptilia TCN16
    transcobalamin I (vitamin B12 binding protein, R b...
    38(a)
    1 ↔ 1
    1(90842492-90860879)


    ENSEMBL Gene Tree for TCN1 (if available)
    TreeFam Gene Tree for TCN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCN1 gene
    GIF2  TCN22  
    1 SIMAP similar gene for TCN1 using alignment to 1 protein entry:     TCO1_HUMAN:
    GIF

    TCN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/384 SNPs in TCN1 are shown (see all 384)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919046761,2
    C--59619882(+) AGGGGA/GTGAGA 1 -- ds50010--------
    rs1162153071,2
    C,F--59619884(+) GGGATG/AAGATT 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1841579971,2
    --59619920(+) TTATGA/TATATG 1 -- ds50010--------
    rs800886711,2
    F--59619931(+) CCTCAC/TGTTTC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1125844731,2
    C,F--59619940(+) TCCCCC/TTTTCT 1 -- ds50012Minor allele frequency- T:0.02CSA WA 120
    rs1495028531,2
    --59619975(+) CACTAC/GCTGTA 1 -- ds50010--------
    rs802048951,2
    C,F--59620015(+) CTTGCA/CTCTGG 1 -- ds50011Minor allele frequency- C:0.03NA 120
    rs725617801,2
    C,F--59620113(-) CAACTG/CGGTAA 1 -- ds50015Minor allele frequency- C:0.01MN 404
    rs1114763001,2
    F--59620153(+) AACCTG/TGAGTA 1 -- ds50011Minor allele frequency- T:0.50CSA 6
    rs755791161,2
    F--59620173(+) TTATTA/TGACAT 1 -- ds50012Minor allele frequency- T:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for TCN1 (59620273 - 59634048 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TCN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2659739CNV Deletion23128226
    nsv825935CNV Loss20364138
    nsv442233CNV CNV18776908


    Human Gene Mutation Database (HGMD): TCN1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TCN1
    DNA2.0 Custom Variant and Variant Library Synthesis for TCN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 189905    OMIM disorders: --

    20/34 diseases for TCN1 (see all 34):    About MalaCards
    pernicious anemia    oral cancer    phyllode tumor    megaloblastic anemia
    follicular lymphoma    neural tube defects    diffuse large b-cell lymphoma    hyperhomocysteinemia
    b-cell lymphomas    cleft palate    colon adenocarcinoma    vascular disease
    anemia    non-hodgkin lymphoma    hodgkin's lymphoma    down syndrome
    crohn's disease    hepatocellular carcinoma    cleft lip    rheumatoid arthritis

    3 diseases from the University of Copenhagen DISEASES database for TCN1:
    Vitamin B12 deficiency     Pernicious anemia     Megaloblastic anemia

    TCN1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for TCN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin b12 deficiency 41.8 1 12356110 (1)
    myeloid leukemia chronic 29.2 1 8301203 (1)
    oral cancer 20.9 3 8820365 (2), 9587699 (1)
    hepatocellular carcinoma 0 1 10101589 (1)
    rheumatoid arthritis 0 3 1602292 (1), 2062181 (1)
    anemia 0 4 1602292 (1)
    tumors 0 1 18413759 (1)

    Genetic Association Database (GAD): TCN1
    Human Genome Epidemiology (HuGE) Navigator: TCN1 (21 documents)

    Export disorders for TCN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCN1 gene, integrated from 9 sources (see all 136):
    (articles sorted by number of sources associating them with TCN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate. (PubMed id 16470748)1, 4, 9 Martinelli M....Carinci F. (2006)
    2. Associations of folate, vitamin B12, homocysteine, an d folate-pathway polymorphisms with prostate-specific antigen velocity in men w ith localized prostate cancer. (PubMed id 20852008)1, 4 Collin S.M....Martin R.M. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Transcobalamin C776G genotype modifies the associatio n between vitamin B12 and homocysteine in older Hispanics. (PubMed id 20216556)1, 4 Garrod M.G....Miller J.W. (2010)
    5. Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. (PubMed id 19303062)1, 4 Tanaka T....Ferrucci L. (2009)
    6. Integrative predictive model of coronary artery calci fication in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (2009)
    7. Folic acid use in pregnancy and embryo selection. (PubMed id 18485163)1, 4 Haggarty P....McNeill G. (2008)
    8. Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma. (PubMed id 18830263)1, 4 Wang S.S....Cerhan J.R. (2008)
    9. One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia. (PubMed id 17891500)1, 4 Lee K.M....Armstrong B.K. (2007)
    10. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6947 HGNC: 11652 AceView: TCN1 Ensembl:ENSG00000134827 euGenes: HUgn6947
    ECgene: TCN1 H-InvDB: TCN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCN1 gene:
    Search GeneIP for patents involving TCN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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