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Aliases for TCN1 Gene

Aliases for TCN1 Gene

  • Transcobalamin I (Vitamin B12 Binding Protein, R Binder Family) 2 3
  • Haptocorrin 2 3 4
  • TC1 3 4 6
  • Haptocorin 2 3
  • Protein R 3 4
  • TC-1 3 4
  • TCI 3 4
  • HC 3 4
  • Transcobalamin-1 3
  • Transcobalamin I 4
  • TC I 4

External Ids for TCN1 Gene

Summaries for TCN1 Gene

Entrez Gene Summary for TCN1 Gene

  • This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCN1 Gene

TCN1 (Transcobalamin I (Vitamin B12 Binding Protein, R Binder Family)) is a Protein Coding gene. Diseases associated with TCN1 include vitamin b12 deficiency and pernicious anemia. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include cobalamin binding. An important paralog of this gene is GIF.

UniProtKB/Swiss-Prot for TCN1 Gene

  • Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach

Gene Wiki entry for TCN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCN1 Gene

Genomics for TCN1 Gene

Genomic Location for TCN1 Gene

Start:
59,852,800 bp from pter
End:
59,866,575 bp from pter
Size:
13,776 bases
Orientation:
Minus strand

Genomic View for TCN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCN1 Gene

Regulatory Elements for TCN1 Gene

Proteins for TCN1 Gene

  • Protein details for TCN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20061-TCO1_HUMAN
    Recommended name:
    Transcobalamin-1
    Protein Accession:
    P20061
    Secondary Accessions:
    • A8KAC5
    • Q8WV77

    Protein attributes for TCN1 Gene

    Size:
    433 amino acids
    Molecular mass:
    48207 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TCN1 Gene

neXtProt entry for TCN1 Gene

Proteomics data for TCN1 Gene at MOPED

Post-translational modifications for TCN1 Gene

  • Contains about 30% carbohydrates
  • Glycosylation at Asn160, Asn216, Asn316, Asn337, Asn343, Asn349, Asn354, and Asn369

Other Protein References for TCN1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TCN1 Gene

Domains for TCN1 Gene

Protein Domains for TCN1 Gene

Suggested Antigen Peptide Sequences for TCN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20061

UniProtKB/Swiss-Prot:

TCO1_HUMAN
Family:
  • Belongs to the eukaryotic cobalamin transport proteins family.:
    • P20061
genes like me logo Genes that share domains with TCN1: view

No data available for Gene Families for TCN1 Gene

Function for TCN1 Gene

Molecular function for TCN1 Gene

GENATLAS Biochemistry: transcobalamin 1 (vitamin B12 binding protein,R binder family),in secondary granules of mature neutrophils
UniProtKB/Swiss-Prot Function: Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach

Gene Ontology (GO) - Molecular Function for TCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031419 cobalamin binding IBA --
genes like me logo Genes that share ontologies with TCN1: view

Phenotypes for TCN1 Gene

GenomeRNAi human phenotypes for TCN1:
genes like me logo Genes that share phenotypes with TCN1: view

miRNA for TCN1 Gene

miRTarBase miRNAs that target TCN1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TCN1 Gene

Localization for TCN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCN1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCN1 Gene COMPARTMENTS Subcellular localization image for TCN1 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
genes like me logo Genes that share ontologies with TCN1: view

Pathways for TCN1 Gene

genes like me logo Genes that share pathways with TCN1: view

Interacting Proteins for TCN1 Gene

Gene Ontology (GO) - Biological Process for TCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0006824 cobalt ion transport IEA --
GO:0009235 cobalamin metabolic process TAS --
GO:0015889 cobalamin transport IEA --
genes like me logo Genes that share ontologies with TCN1: view

Compounds for TCN1 Gene

(3) HMDB Compounds for TCN1 Gene

Compound Synonyms Cas Number PubMed IDs
Cobalamin
  • 5,6-dimethyl-1-a-D-ribofuranosylbenzimidazole
13408-78-1
Cobalt
  • Co
7440-48-4
Cyanocobalamin
  • Dimethylbenzimidazoylcobamide
68-19-9

(2) Drugbank Compounds for TCN1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cyanocobalamin
  • Cyanocob(III)alamin
68-19-9 transporter substrate
Hydroxocobalamin
  • Hydroxomin
13422-51-0 target other

(9) Novoseek inferred chemical compound relationships for TCN1 Gene

Compound -log(P) Hits PubMed IDs
cobalamin 93.9 35
vitamin b12 87.9 33
cobinamide 87.1 1
methylmalonic acid 81.4 1
corrinoid 67.7 4
genes like me logo Genes that share compounds with TCN1: view

Transcripts for TCN1 Gene

mRNA/cDNA for TCN1 Gene

Unigene Clusters for TCN1 Gene

Transcobalamin I (vitamin B12 binding protein, R binder family):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1:
SP2: -
SP3: - -

Relevant External Links for TCN1 Gene

GeneLoc Exon Structure for
TCN1
ECgene alternative splicing isoforms for
TCN1

Expression for TCN1 Gene

mRNA expression in normal human tissues for TCN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCN1 Gene

This gene is overexpressed in Minor Salivary Gland (35.5), Whole Blood (7.2), and Stomach (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TCN1 Gene

SOURCE GeneReport for Unigene cluster for TCN1 Gene Hs.2012

mRNA Expression by UniProt/SwissProt for TCN1 Gene

P20061-TCO1_HUMAN
Tissue specificity: Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils.
genes like me logo Genes that share expressions with TCN1: view

Orthologs for TCN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCN1 35
  • 98.48 (n)
  • 98.12 (a)
TCN1 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCN1 35
  • 73.38 (n)
  • 63 (a)
TCN1 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCN1 35
  • 77.06 (n)
  • 63.28 (a)
TCN1 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCN1 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCN1 36
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for TCN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCN1 Gene

ENSEMBL:
Gene Tree for TCN1 (if available)
TreeFam:
Gene Tree for TCN1 (if available)

Paralogs for TCN1 Gene

Paralogs for TCN1 Gene

Selected SIMAP similar genes for TCN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCN1: view

Variants for TCN1 Gene

Sequence variations from dbSNP and Humsavar for TCN1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs482092 -- 59,860,582(+) TTTAG(C/T)CATGT intron-variant
rs519221 -- 59,857,063(+) CCACA(A/T)GCATT intron-variant
rs520276 -- 59,857,205(+) TAGGC(A/C)ATtag intron-variant
rs526934 -- 59,866,020(+) TCAGG(A/G)AAAAA intron-variant
rs529461 -- 59,856,739(+) GAAGT(G/T)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCN1 Gene

Variant ID Type Subtype PubMed ID
nsv825935 CNV Loss 20364138
nsv442233 CNV CNV 18776908
esv2659739 CNV Deletion 23128226

Relevant External Links for TCN1 Gene

HapMap Linkage Disequilibrium report
TCN1
Human Gene Mutation Database (HGMD)
TCN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCN1 Gene

Disorders for TCN1 Gene

(3) University of Copenhagen DISEASES for TCN1 Gene

(7) Novoseek inferred disease relationships for TCN1 Gene

Disease -log(P) Hits PubMed IDs
vitamin b12 deficiency 41.8 1
myeloid leukemia chronic 29.2 1
oral cancer 20.9 3
hepatocellular carcinoma 0 1
rheumatoid arthritis 0 2

Relevant External Links for TCN1

Genetic Association Database (GAD)
TCN1
Human Genome Epidemiology (HuGE) Navigator
TCN1
genes like me logo Genes that share disorders with TCN1: view

No data available for UniProtKB/Swiss-Prot for TCN1 Gene

Publications for TCN1 Gene

  1. Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate. (PMID: 16470748) Martinelli M. … Carinci F. (Hum. Mutat. 2006) 3 23 48
  2. Transcellular transport of vitamin B(12) in LLC-PK1 renal proximal tubule cells. (PMID: 11373332) Nielsen R. … E. (J. Am. Soc. Nephrol. 2001) 3 23
  3. Comparative analysis of cobalamin binding kinetics and ligand protection for intrinsic factor, transcobalamin, and haptocorrin. (PMID: 11788601) Fedosov S.N. … Petersen T.E. (J. Biol. Chem. 2002) 3 23
  4. Genomic structure and mapping of the chromosomal gene for transcobalamin I (TCN1): comparison to human intrinsic factor. (PMID: 1463480) Johnston J. … Berliner N. (Genomics 1992) 3 23
  5. Mechanisms of discrimination between cobalamins and their natural analogues during their binding to the specific B12-transporting proteins. (PMID: 17487979) Fedosov S.N. … Petersen T.E. (Biochemistry 2007) 3 23

Products for TCN1 Gene

Sources for TCN1 Gene

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