|
|
T-cell leukemia/lymphoma 6 (non-protein coding)(Previous name: T-cell leukemia/lymphoma 6 )
| |
Aliases
for TCL6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): lncRNA
Quality score for this RNA gene is 3
| Aliases |
|---|
| T-Cell Leukemia/Lymphoma 6 (Non-Protein Coding)1 2 | | TNG11 2 5 | | TNG21 2 5 | | TCL6e11 | | T-Cell Leukemia/Lymphoma 61 |
Export aliases for TCL6 gene to outside databasesPrevious GC identifers: GC14U990093 GC14P089934 GC14P094106 GC14P094107 GC14P095187 GC14P076303 |
Summaries
for TCL6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TCL6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TCL6 gene promoter:
Pax-6 MyoD Nkx2-5 Evi-1 RORalpha1 MZF-1 FAC1 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCL6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCL6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.1 Ensembl cytogenetic band: 14q32.13 HGNC cytogenetic band: 14q32.1TCL6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P096116: view genomic region
(about GC identifiers)
Start:
|
96,116,835 bp from pter |
End:
|
96,146,170 bp from pter |
Size:
|
29,336 bases |
Orientation:
|
plus strand |
|
Proteins
for TCL6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB: --
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_
TCL6 Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
TCL6 for ontologies About GeneDecksing
Antibody Products for TCL6:
Assay Products for TCL6: |
Protein
Domains /
Families
for TCL6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for TCL6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCL6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCL6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for TCL6 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCL6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCL6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCL6 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TCL6 for ontologies About GeneDecksing
|
Pathways & Interactions
for TCL6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCL6
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
TCL6 for ontologies About GeneDecksing
|
Drugs & Compounds
for TCL6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TCL6
Search CenterWatch for drugs/clinical trials and news about TCL6
|
Transcripts
for TCL6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCL6 gene (6 alternative transcripts): NM_012468.4 NM_014418.3 NM_020550.3 NM_020552.3 NM_020553.3 NM_020554.3 Unigene Clusters for TCL6: T-cell leukemia/lymphoma 6 (non-protein coding) Hs.510368 [show with all ESTs], Hs.732224 [show with all ESTs]Unigene Representative Sequences: AB035335, BC04107511 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357168(lincRNA)(uc001yep.1) ENST00000460130(lincRNA) ENST00000483087(lincRNA)(uc021sbf.1)
ENST00000459662(lincRNA)(uc021sbg.1) ENST00000484207(lincRNA)(uc021sbh.1) ENST00000467865(lincRNA)(uc001yet.1)
ENST00000352367(lincRNA)(uc001yeu.2) ENST00000497248(lincRNA)(uc001yev.2) ENST00000486671(lincRNA)
ENST00000465501(lincRNA) ENST00000495696(lincRNA)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCL6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCL6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TCL6 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCL6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCL6 |
Additional cDNA sequence: AF195820.1 BC041075.1 13 DOTS entries: DT.75155586 DT.100726219 DT.40242986 DT.120732291 DT.101981566 DT.100726222 DT.108708 DT.92016876 DT.100726221 DT.40131517 DT.421180 DT.95272702 DT.97822999 24/162 AceView cDNA sequences (see all 162): AA285071 BC051000 AB035341 CR600897 NM_020550 BQ024152 AF110466 H03864 BQ055042 AB035343 NM_020552 AI219070 NM_020554 BQ228977 AB035342 BQ062043 BQ011141 AI650299 AA693685 NM_012468 NM_014418 BF511117 BF589188 NM_004918
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TCL6 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|
|
| SP1: | | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TCL6
|
Expression
for TCL6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for TCL6:none
TCL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATGGAATG
About this image
Genevestigator expression for TCL6
SOURCE GeneReport for Unigene clusters: Hs.510368 Hs.732224
SABiosciences Custom PCR Arrays for TCL6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCL6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TCL6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCL6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCL6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCL6 |
Orthologs
for TCL6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for TCL6 (if available)
TreeFam Gene Tree for TCL6 (if available) |
Paralogs
for TCL6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TCL6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TCL6 (96116835 - 96146170 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TCL6
1 CNV: 8775 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCL6 |
|
Disorders
/ Diseases
for TCL6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCL6 for disorders About GeneDecksing
OMIM gene information: 604412
OMIM disorders: --
3  diseases for TCL6: About MalaCardsleukemia/lymphoma t-cell leukemia leukemia
Export disorders for TCL6 gene to outside databases
|
Publications
for TCL6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCL6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TCL6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia. (PubMed id 10851082)1, 3 Saitou M....Isobe M. (2000)
- Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes. (PubMed id 10588720)1, 3 Hallas C.... Croce C.M. (1999)
- Molecular basis of mature T-cell leukemia. (PubMed id 11710897)1, 9 Pekarsky Y....Croce C.M. (2001)
- A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PubMed id 20031603)1 Marroni F....Pramstaller P.P. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TCL6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TCL6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCL6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCL6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TCL6 gene:
Search GeneIP for patents involving TCL6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCL6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TCL6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCL6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCL6 | | | OriGene Protein Over-expression Lysate for TCL6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TCL6 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCL6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCL6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TCL6 | | OriGene Custom Protein Services for TCL6 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCL6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCL6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCL6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCL6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCL6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCL6 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TCL6 |
| |  |  |  |  | | | | |
 |
 |
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 | | | TCL6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCL6 |
|  |  |  | | | | ThermoFisher Antibodies for TCL6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCL6 |
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