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Aliases for TCL6 Gene

Subcategory (RNA class) for TCL6 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for TCL6 Gene

  • T-Cell Leukemia/Lymphoma 6 (Non-Protein Coding) 2 3 5
  • T-Cell Leukemia/Lymphoma 6 2
  • TCL1-Neighboring Gene 1 3
  • TCL1-Neighboring Gene 2 3
  • TNG1 3
  • TNG2 3

External Ids for TCL6 Gene

Previous GeneCards Identifiers for TCL6 Gene

  • GC14U990093
  • GC14P089934
  • GC14P094106
  • GC14P094107
  • GC14P095187
  • GC14P096116
  • GC14P076303

Summaries for TCL6 Gene

GeneCards Summary for TCL6 Gene

TCL6 (T-Cell Leukemia/Lymphoma 6 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with TCL6 include T-Cell Leukemia.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCL6 Gene

Genomics for TCL6 Gene

Regulatory Elements for TCL6 Gene

Enhancers for TCL6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F095659 1.1 Ensembl ENCODE 12.1 +13.3 13314 7.9 PKNOX1 TBL1XR1 BMI1 SCRT2 CREM EGR2 ZNF362 CBFB JUNB USF2 TCL6 TCL1A TCL1B ENSG00000258927 GLRX5 ENSG00000259084 ENSG00000277468
GH14F095597 1 Ensembl ENCODE 13 -52.5 -52490 1.3 MAX ZIC2 ZKSCAN1 HIC1 ZFHX2 GATA3 GLIS2 ZNF366 ZNF207 PRDM10 ENSG00000258927 ENSG00000258516 ENSG00000258866 ENSG00000258729 TCL6 ENSG00000270038 GLRX5 LOC105370643
GH14F095634 0.8 ENCODE 13.2 -14.9 -14944 2.2 CTCF SIN3A ZNF2 ZBTB40 RAD21 CTBP1 GATA3 ZNF143 SMC3 NR2F6 ENSG00000258927 TCL6 TCL1A ENSG00000270038
GH14F095543 1.5 FANTOM5 Ensembl ENCODE 5.1 -104.2 -104212 5.4 ATF1 ARID4B ZNF48 YY1 GATA2 FOS JUNB TSHZ1 ZNF518A SREBF1 GLRX5 SNHG10 LOC101929107 TCL6 GC14M095530 LOC100506999
GH14F095577 0.7 ENCODE 8.3 -73.2 -73200 0.2 PKNOX1 TBL1XR1 MTA2 BHLHE40 ASH2L TBX21 EP300 RELA IKZF1 TARDBP TCL6 GLRX5 LOC100506999 LOC105370643
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCL6 Gene

Chromosome:
14
Start:
95,650,498 bp from pter
End:
95,679,833 bp from pter
Size:
29,336 bases
Orientation:
Plus strand

Genomic View for TCL6 Gene

Genes around TCL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCL6 Gene

Proteins for TCL6 Gene

  • Protein details for TCL6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024R6G0
    Recommended name:
    T-cell leukemia/lymphoma 6, isoform CRA_b
    Protein Accession:
    A0A024R6G0

    Protein attributes for TCL6 Gene

    Size:
    141 amino acids
    Molecular mass:
    15855 Da
    Quaternary structure:
    No Data Available
  • Protein details for TCL6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024R6J2
    Recommended name:
    T-cell leukemia/lymphoma 6, isoform CRA_d
    Protein Accession:
    A0A024R6J2

    Protein attributes for TCL6 Gene

    Size:
    163 amino acids
    Molecular mass:
    18579 Da
    Quaternary structure:
    No Data Available
  • Protein details for TCL6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024R6J5
    Recommended name:
    T-cell leukemia/lymphoma 6, isoform CRA_a
    Protein Accession:
    A0A024R6J5

    Protein attributes for TCL6 Gene

    Size:
    119 amino acids
    Molecular mass:
    13961 Da
    Quaternary structure:
    No Data Available
  • Protein details for TCL6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024R6L9
    Recommended name:
    T-cell leukemia/lymphoma 6, isoform CRA_c
    Protein Accession:
    A0A024R6L9

    Protein attributes for TCL6 Gene

    Size:
    103 amino acids
    Molecular mass:
    12064 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCL6 Gene

Post-translational modifications for TCL6 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TCL6 Gene

Domains & Families for TCL6 Gene

Protein Domains for TCL6 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TCL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TCL6: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TCL6 Gene

Function for TCL6 Gene

Phenotypes for TCL6 Gene

GenomeRNAi human phenotypes for TCL6:
genes like me logo Genes that share phenotypes with TCL6: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCL6 Gene

Localization for TCL6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCL6 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TCL6 Gene

Pathways & Interactions for TCL6 Gene

No Data Available

Interacting Proteins for TCL6 Gene

Gene Ontology (GO) - Biological Process for TCL6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCL6 Gene

Transcripts for TCL6 Gene

Unigene Clusters for TCL6 Gene

T-cell leukemia/lymphoma 6 (non-protein coding):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCL6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - -
SP5: - - -
SP6: -
SP7: - - -
SP8:
SP9:

Relevant External Links for TCL6 Gene

GeneLoc Exon Structure for
TCL6
ECgene alternative splicing isoforms for
TCL6

Expression for TCL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCL6 Gene

mRNA differential expression in normal tissues according to GTEx for TCL6 Gene

This gene is overexpressed in Kidney - Cortex (x15.2), Whole Blood (x9.1), and Spleen (x6.5).

NURSA nuclear receptor signaling pathways regulating expression of TCL6 Gene:

TCL6

SOURCE GeneReport for Unigene cluster for TCL6 Gene:

Hs.510368
genes like me logo Genes that share expression patterns with TCL6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TCL6 Gene

Orthologs for TCL6 Gene

Evolution for TCL6 Gene

ENSEMBL:
Gene Tree for TCL6 (if available)
TreeFam:
Gene Tree for TCL6 (if available)

No data available for Orthologs for TCL6 Gene

Paralogs for TCL6 Gene

No data available for Paralogs for TCL6 Gene

Variants for TCL6 Gene

Sequence variations from dbSNP and Humsavar for TCL6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10133102 -- 95,671,011(+) TTGCT(A/G)CCTGT intron-variant
rs10133326 -- 95,655,002(+) ggggg(C/T)ggttt intron-variant
rs10134151 -- 95,649,825(+) TAAAA(A/T)TAAAT upstream-variant-2KB
rs10136498 -- 95,655,865(+) ctcac(C/T)atcat intron-variant
rs10140227 -- 95,657,367(+) CAATT(A/T)GTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCL6 Gene

Variant ID Type Subtype PubMed ID
nsv565645 CNV loss 21841781
nsv565644 CNV loss 21841781
nsv565631 CNV gain 21841781
nsv456410 CNV loss 19166990
nsv1047138 CNV loss 25217958
nsv1046191 CNV gain 25217958
nsv1042858 CNV gain 25217958
esv3635405 CNV loss 21293372
esv3635404 CNV gain 21293372
esv3635403 CNV gain 21293372
dgv89e55 CNV gain 17911159

Relevant External Links for TCL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TCL6 Gene

Disorders for TCL6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCL6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
- elite association - COSMIC cancer census association via MalaCards
Search TCL6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCL6

Genetic Association Database (GAD)
TCL6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCL6
genes like me logo Genes that share disorders with TCL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCL6 Gene

Publications for TCL6 Gene

  1. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PMID: 20031603) Marroni F. … Pramstaller P.P. (Circ Cardiovasc Genet 2009) 3 46 64
  2. Molecular basis of mature T-cell leukemia. (PMID: 11710897) Pekarsky Y. … Croce C.M. (JAMA 2001) 3 22 64
  3. Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia. (PMID: 10851082) Saitou M. … Isobe M. (Oncogene 2000) 2 3 64
  4. Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes. (PMID: 10588720) Hallas C. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for TCL6 Gene

Sources for TCL6 Gene

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