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TCL1B Gene

protein-coding   GIFtS: 54
GCID: GC14P096152

T-Cell Leukemia/Lymphoma 1B

  See TCL1B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T-Cell Leukemia/Lymphoma 1B1 2     T-Cell Lymphoma/Leukemia 1B2
Oncogene TCL-1B2 3     TCL1/ MTCP1-Like 12
Syncytiotrophoblast-Specific Protein2 3     TCL13
SYN-12 3     Oncogene TCL1B3
TML12 5     TCL1/MTCP1-Like Protein 13
T-Cell Leukemia/Lymphoma Protein 1B2     

External Ids:    HGNC: 116491   Entrez Gene: 96232   Ensembl: ENSG000002132317   OMIM: 6037695   UniProtKB: O959883   

Export aliases for TCL1B gene to outside databases

Previous GC identifers: GC14P093628 GC14P089969 GC14P094118 GC14P094142 GC14P095198 GC14P095222 GC14P076338


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TCL1B Gene:
TCL1B (T-cell leukemia/lymphoma 1B) is a protein-coding gene. Diseases associated with TCL1B include leukemia/lymphoma, t-cell, and t-cell leukemia. An important paralog of this gene is MTCP1.

UniProtKB/Swiss-Prot: TCL1B_HUMAN, O95988
Function: Enhances the phosphorylation and activation of AKT1 and AKT2

Gene Wiki entry for TCL1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCL1B gene promoter:
         AP-2rep   p53   AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   POU3F2   Nkx5-1   MZF-1   S8   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCL1B promoter sequence
   Search Chromatin IP Primers for TCL1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCL1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.1   Ensembl cytogenetic band:  14q32.13   HGNC cytogenetic band: 14q32.1

TCL1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCL1B gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P096152:  view genomic region     (about GC identifiers)

Start:
96,152,754 bp from pter      End:
96,158,980 bp from pter
Size:
6,227 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCL1B_HUMAN, O95988 (See protein sequence)
Recommended Name: T-cell leukemia/lymphoma protein 1B  
Size: 128 amino acids; 14846 Da
Subunit: Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3
Miscellaneous: Activated in chronic T-cell leukemias (T-CLL) carrying rearrangements of the 14q32.1 region
Secondary accessions: A6NEK7 Q6IAR7 Q9UBQ4

Explore the universe of human proteins at neXtProt for TCL1B: NX_O95988

Explore proteomics data for TCL1B at MOPED


See TCL1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004909.1  
ENSEMBL proteins: 
 ENSP00000343223  

TCL1B Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for TCL1B

 
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LSBio Antibodies in human, mouse, rat for TCL1B

TCL1B Assay Products:

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Search eBioscience for ELISAs for TCL1B 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR004832 TCL1_MTCP1

Graphical View of Domain Structure for InterPro Entry O95988

ProtoNet protein and cluster: O95988

1 Blocks protein domain: IPB004832 TCL1/MTCP1 family

UniProtKB/Swiss-Prot: TCL1B_HUMAN, O95988
Similarity: Belongs to the TCL1 family


Find genes that share domains with TCL1B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TCL1B_HUMAN, O95988
Function: Enhances the phosphorylation and activation of AKT1 and AKT2

     Genatlas biochemistry entry for TCL1B:
T cell leukemia transcript 1b,14kDa,highly similar to TCL1A,with the same pattern of low expression in normal bone
marrow and peripheral lymphocytes but activated in T cell leukemias by rearrangements of 14q32.1 region

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCL1B
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCL1B
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TCL1B

miRNA
Products:
    
miRTarBase miRNAs that target TCL1B:
hsa-mir-9-5p (MIRT021345), hsa-mir-7-5p (MIRT025631)

Block miRNA regulation of human, mouse, rat TCL1B using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate TCL1B:
hsa-miR-922 hsa-miR-561
SwitchGear 3'UTR luciferase reporter plasmidTCL1B 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for TCL1B
Predesigned siRNA for gene silencing in human, mouse, rat TCL1B

Gene Editing
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Clone
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OriGene clones in human, mouse for TCL1B (see all 8)
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GenScript: all cDNA clones in your preferred vector: TCL1B (NM_004918)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCL1B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCL1B

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCL1B


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2
mitochondrion1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TCL1B About    
See pathways by source

SuperPathContained pathways About
1PI3K-Akt signaling pathway
PI3K-Akt signaling pathway


Find genes that share SuperPaths with TCL1B           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Kegg Pathway  (Kegg details for TCL1B):
    PI3K-Akt signaling pathway

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCL1B
Interactions:

    GeneGlobe Interaction Network for TCL1B

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for TCL1B (O959882, 3 ENSP000003432234) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
AKT2P317513, ENSP000003758924I2D: score=3 STRING: ENSP00000375892
AKT1P317493, ENSP000002702024I2D: score=3 STRING: ENSP00000270202
TNPO2O147873, ENSP000003973794I2D: score=3 STRING: ENSP00000397379
--Q9HA672MINT-65535
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TCL1B



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TCL1B gene (2 alternative transcripts): 
NM_199206.2  NM_004918.3  

Unigene Cluster for TCL1B:

T-cell leukemia/lymphoma 1B
Hs.632346  [show with all ESTs]
Unigene Representative Sequence: AB018563
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000340722(uc001yez.3) ENST00000464815(uc001yfa.3) ENST00000556665

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat TCL1B using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate TCL1B:
hsa-miR-922 hsa-miR-561
SwitchGear 3'UTR luciferase reporter plasmidTCL1B 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for TCL1B
Predesigned siRNA for gene silencing in human, mouse, rat TCL1B
Clone
Products:
     
OriGene clones in human, mouse for TCL1B (see all 8)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TCL1B (NM_004918)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCL1B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCL1B
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TCL1B
OriGene qSTAR qPCR primer pairs in human, mouse for TCL1B
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TCL1B
  QuantiTect SYBR Green Assays in human, mouse, rat TCL1B
  QuantiFast Probe-based Assays in human, mouse, rat TCL1B

Additional mRNA sequence: 

AB018563.1 AF110466.1 AF137027.1 BC041616.1 BC051000.1 CR457087.1 

5 DOTS entries:

DT.304976  DT.100726221  DT.92417349  DT.121634051  DT.95358784 

Selected AceView cDNA sequences (see all 162):

AA693685 BQ062043 AI498415 CR600897 BC041075 AA285071 AI650299 BC041616 
BQ228977 AF195820 BF511117 NM_004918 BX161462 BX110858 AB035342 BC051000 
AF110466 AB035341 NM_020554 NM_020552 H03864 BE326927 BQ061440 AB035343 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TCL1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCAGATTGA
TCL1B Expression
About this image


TCL1B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Ovary (Reproductive System)
         Secondary Oocyte Antral Follicle
 
 Gonad
         Secondary Oocyte Antral Follicle
 
 Blood (Hematopoietic System)
         Mature B-Cells Peripheral Blood
 
 Pancreas (Endocrine System)
 
 Placenta (Extraembryonic Tissues)
TCL1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TCL1B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.632346

UniProtKB/Swiss-Prot: TCL1B_HUMAN, O95988
Tissue specificity: Expressed in a variety of tissues including placenta and testis

    Custom PCR Arrays for TCL1B
Primer
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QuantiTect SYBR Green Assays in human, mouse, rat TCL1B
QuantiFast Probe-based Assays in human, mouse, rat TCL1B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCL1B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TCL1B gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
29(a)
1 → many
GL343528.1(421305-421616)
        Species with no ortholog for TCL1B

ENSEMBL Gene Tree for TCL1B (if available)
TreeFam Gene Tree for TCL1B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TCL1B gene
MTCP12  TCL1A2  
2 SIMAP similar genes for TCL1B using alignment to 1 protein entry:     TCL1B_HUMAN:
MTCP1    TCL1A

Find genes that share paralogs with TCL1B           About GenesLikeMe


1 Pseudogenes.org Pseudogene for TCL1B
PGOHUM00000235610


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TCL1B (see all 268)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs49053721,2
H--96150878(+) TTGGCC/AAAGGC 1 -- us2k14Minor allele frequency- A:0.00NS EA 398
rs1152036491,2
C,F--96150899(+) CAGCAT/GGCATG 1 -- us2k11Minor allele frequency- G:0.03WA 118
rs101413401,2
C,F,H--96150909(+) GTTAGA/GGCCAG 1 -- us2k116Minor allele frequency- G:0.09NS EA NA CSA WA 1885
rs1818523491,2
--96151041(+) GAGGTA/GTTAGT 1 -- us2k10--------
rs37595351,2
H--96151053(-) ATAGGG/ATATCT 1 -- us2k14Minor allele frequency- A:0.00NS EA 408
rs1383468551,2
--96151109(+) CCTTTA/GCCTCC 1 -- us2k10--------
rs1409608781,2
--96151171(+) TCAAAA/GTATAT 1 -- us2k10--------
rs14750891,2
C,F,A,H--96151208(+) AATAGT/CAATTG 1 -- us2k134Minor allele frequency- C:0.11EA NA NS WA CSA 4388
rs21810661,2
C,F,O,A,H--96151250(+) TCTGCC/TTGGGA 1 -- us2k119Minor allele frequency- T:0.39EA NA NS WA 1412
rs1501900171,2
--96151298(+) TATTTA/CAAGTA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for TCL1B (96152754 - 96158980 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TCL1B: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TCL1B
DNA2.0 Custom Variant and Variant Library Synthesis for TCL1B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603769    OMIM disorders: --

2 diseases for TCL1B:    
About MalaCards
leukemia/lymphoma, t-cell    t-cell leukemia


Find genes that share disorders with TCL1B           About GenesLikeMe

3 Novoseek inferred disease relationships for TCL1B gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia t-cell 82.9 11 10851082 (3), 11607815 (2), 10588720 (1), 11752899 (1) (see all 5)
leukemogenesis 74.7 3 10851082 (1), 10344735 (1)
lymphoma 45.8 4 10851082 (1), 11607815 (1)

Genetic Association Database (GAD): TCL1B
Human Genome Epidemiology (HuGE) Navigator: TCL1B (1 document)

Export disorders for TCL1B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TCL1B gene, integrated from 10 sources (see all 20):
(articles sorted by number of sources associating them with TCL1B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes. (PubMed id 10077617)1, 2, 3, 9 Pekarsky Y.... Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 1999)
  2. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PubMed id 11707444)1, 2, 9 Laine J.... Noguchi M. (J. Biol. Chem. 2002)
  3. Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus. (PubMed id 10344735)1, 2, 9 Sugimoto J.... Isobe M. (Cancer Res. 1999)
  4. The protooncogene TCL1 is an Akt kinase coactivator. (PubMed id 10983986)1, 2, 9 Laine J.... Noguchi M. (Mol. Cell 2000)
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
  6. Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia. (PubMed id 10851082)1, 9 Saitou M.... Isobe M. (Oncogene 2000)
  7. The role of TCL1 in human T-cell leukemia. (PubMed id 11607815)1, 9 Pekarsky Y....Croce C.M. (Oncogene 2001)
  8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  9. Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors. (PubMed id 20876420)4 Ingle J.N....Weinshilboum R.M. (J. Clin. Oncol. 2010)
  10. Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications. (PubMed id 20228224)1 Badve S....Nakshatri H. (Am. J. Pathol. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9623 HGNC: 11649 AceView: TCL1BandTCL6 Ensembl:ENSG00000213231 euGenes: HUgn9623
ECgene: TCL1B Kegg: 9623 H-InvDB: TCL1B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TCL1B Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TCL1B Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TCL1B gene:
Search GeneIP for patents involving TCL1B

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore genomic analysis products

  
 Antibodies for TCL1B (TCL1B)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
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 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
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 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TCL1B  
 OriGene qPCR primer pairs and template standards for TCL1B   OriGene Protein Over-expression Lysate for TCL1B  
 OriGene MassSpec something-or-other for TCL1B   OriGene clones in human, mouse for TCL1B  
 OriGene qSTAR qPCR primer pairs in human, mouse for TCL1B   OriGene Purified Protein for TCL1B  
 Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for TCL1B   OriGene Custom Protein Services for TCL1B  

 
 
 Block miRNA regulation of human, mouse, rat TCL1B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TCL1B
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCL1B Predesigned siRNA for gene silencing in human, mouse, rat TCL1B
 QuantiFast Probe-based Assays in human, mouse, rat TCL1B QuantiTect SYBR Green Assays in human, mouse, rat TCL1B
 Custom PCR Arrays for TCL1B Search Chromatin IP Primers for TCL1B
 Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TCL1B  GeneGlobe Interaction Network for TCL1B
 Regulatory tfbs in TCL1B promoter
 GenScript Custom Purified and Recombinant Proteins Services for TCL1B GenScript cDNA clones with any tag delivered in your preferred vector for TCL1B
 GenScript Custom Assay Services for TCL1B GenScript Custom overexpressing Cell Line Services for TCL1B
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for TCL1B
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 TCL1B antibodies
 TCL1B proteins
 TCL1B lysates
 Antibodies for TCL1B
 See all of Abcam's Antibodies, Kits and Proteins for TCL1B
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for TCL1B
 Antibodies for TCL1B
 ELISAs for TCL1B
 CLIAs for TCL1B



 Browse ESI BIO Cell Lines and PureStem Progenitors for TCL1B
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCL1B
 SwitchGear 3'UTR luciferase reporter plasmids for TCL1B
 SwitchGear Promoter luciferase reporter plasmids for TCL1B
 Search ThermoFisher Antibodies for TCL1B
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCL1B
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCL1B
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TCL1B
 LSBio Antibodies in human, mouse, rat for TCL1B
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for TCL1B
  Search eBioscience for proteins for TCL1B
  Search eBioscience for elisas for TCL1B
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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