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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCL1B Gene

protein-coding   GIFtS: 55
GCID: GC14P096152

T-Cell Leukemia/Lymphoma 1B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T-Cell Leukemia/Lymphoma 1B1 2     T-Cell Lymphoma/Leukemia 1B2
Oncogene TCL-1B2 3     TCL1/ MTCP1-Like 12
Syncytiotrophoblast-Specific Protein2 3     TCL13
SYN-12 3     Oncogene TCL1B3
TML12 5     TCL1/MTCP1-Like Protein 13
T-Cell Leukemia/Lymphoma Protein 1B2     

External Ids:    HGNC: 116491   Entrez Gene: 96232   Ensembl: ENSG000002132317   OMIM: 6037695   UniProtKB: O959883   

Export aliases for TCL1B gene to outside databases

Previous GC identifers: GC14P093628 GC14P089969 GC14P094118 GC14P094142 GC14P095198 GC14P095222 GC14P076338


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TCL1B Gene: 
TCL1B (T-cell leukemia/lymphoma 1B) is a protein-coding gene. Diseases associated with TCL1B include t-cell leukemia, and prolymphocytic leukemia.

UniProtKB/Swiss-Prot: TCL1B_HUMAN, O95988
Function: Enhances the phosphorylation and activation of AKT1 and AKT2

Gene Wiki entry for TCL1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCL1B gene promoter:
         AP-2rep   p53   AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   POU3F2   Nkx5-1   MZF-1   S8   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCL1B promoter sequence
   Search SABiosciences Chromatin IP Primers for TCL1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCL1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.1   Ensembl cytogenetic band:  14q32.13   HGNC cytogenetic band: 14q32.1

TCL1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCL1B gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P096152:  view genomic region     (about GC identifiers)

Start:
96,152,754 bp from pter      End:
96,158,980 bp from pter
Size:
6,227 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCL1B_HUMAN, O95988 (See protein sequence)
Recommended Name: T-cell leukemia/lymphoma protein 1B  
Size: 128 amino acids; 14846 Da
Subunit: Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3
Miscellaneous: Activated in chronic T-cell leukemias (T-CLL) carrying rearrangements of the 14q32.1 region
Secondary accessions: A6NEK7 Q6IAR7 Q9UBQ4

Explore the universe of human proteins at neXtProt for TCL1B: NX_O95988

Explore proteomics data for TCL1B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95988

  • TCL1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCL1B Protein Expression
    REFSEQ proteins: NP_004909.1  
    ENSEMBL proteins: 
     ENSP00000343223  

    Human Recombinant Protein Products for TCL1B: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR004832 TCL1_MTCP1

    Graphical View of Domain Structure for InterPro Entry O95988

    ProtoNet protein and cluster: O95988

    1 Blocks protein domain: IPB004832 TCL1/MTCP1 family

    UniProtKB/Swiss-Prot: TCL1B_HUMAN, O95988
    Similarity: Belongs to the TCL1 family


    TCL1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCL1B_HUMAN, O95988
    Function: Enhances the phosphorylation and activation of AKT1 and AKT2

         Genatlas biochemistry entry for TCL1B:
    T cell leukemia transcript 1b,14kDa,highly similar to TCL1A,with the same pattern of low expression in normal bone
    marrow and peripheral lymphocytes but activated in T cell leukemias by rearrangements of 14q32.1 region

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TCL1B 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCL1B 
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TCL1B:
    hsa-miR-922 hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidTCL1B 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCL1B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TCL1B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for TCL1B):
        PI3K-Akt signaling pathway


    TCL1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCL1B

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for TCL1B (O959882, 3 ENSP000003432234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKT2P317513, ENSP000003758924I2D: score=3 STRING: ENSP00000375892
    AKT1P317493, ENSP000002702024I2D: score=3 STRING: ENSP00000270202
    TNPO2O147873, ENSP000003973794I2D: score=3 STRING: ENSP00000397379
    --Q9HA672MINT-65535
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCL1B

    Search CenterWatch for drugs/clinical trials and news about TCL1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCL1B gene (2 alternative transcripts): 
    NM_199206.2  NM_004918.3  

    Unigene Cluster for TCL1B:

    T-cell leukemia/lymphoma 1B
    Hs.632346  [show with all ESTs]
    Unigene Representative Sequence: AB018563
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340722(uc001yez.3) ENST00000464815(uc001yfa.3) ENST00000556665

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TCL1B:
    hsa-miR-922 hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidTCL1B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    OriGene clones in human, mouse for TCL1B (see all 10)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCL1B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCL1B

    Additional mRNA sequence: 

    AB018563.1 AF110466.1 AF137027.1 BC041616.1 BC051000.1 CR457087.1 

    5 DOTS entries:

    DT.304976  DT.100726221  DT.92417349  DT.121634051  DT.95358784 

    24/162 AceView cDNA sequences (see all 162):

    NM_014418 BX110858 BX161462 H03864 AI219070 BC041075 AB035343 BQ228977 
    BQ058954 AA285071 BF511117 NM_012468 BF589188 NM_020550 BQ011141 BQ061440 
    AF110466 BC041616 AA693685 AB035342 NM_020554 BC051000 AI498415 NM_004918 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCL1B expression in normal human tissues (normalized intensities)      TCL1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAGATTGA
    TCL1B Expression
    About this image


    TCL1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             LYMPH NODE   
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Inner Cell Mass (Early Embryonic Tissues)
             ESI-049   
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Pancreas (Endocrine System)

    See TCL1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCL1B

    SOURCE GeneReport for Unigene cluster: Hs.632346

    UniProtKB/Swiss-Prot: TCL1B_HUMAN, O95988
    Tissue specificity: Expressed in a variety of tissues including placenta and testis

        SABiosciences Custom PCR Arrays for TCL1B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCL1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TCL1B gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    29(a)
    1 → many
    GL343528.1(421305-421616)
            Species with no ortholog for TCL1B

    ENSEMBL Gene Tree for TCL1B (if available)
    TreeFam Gene Tree for TCL1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCL1B gene
    2 SIMAP similar genes for TCL1B using alignment to 1 protein entry:     TCL1B_HUMAN:
    MTCP1    TCL1A

    TCL1B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TCL1B
    PGOHUM00000235610


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/268 SNPs in TCL1B are shown (see all 268)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs49053721,2
    H--96150878(+) TTGGCC/AAAGGC 1 -- us2k14Minor allele frequency- A:0.00NS EA 398
    rs1152036491,2
    C,F--96150899(+) CAGCAT/GGCATG 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs101413401,2
    C,F,H--96150909(+) GTTAGA/GGCCAG 1 -- us2k116Minor allele frequency- G:0.09NS EA NA CSA WA 1885
    rs1818523491,2
    --96151041(+) GAGGTA/GTTAGT 1 -- us2k10--------
    rs37595351,2
    H--96151053(-) ATAGGG/ATATCT 1 -- us2k14Minor allele frequency- A:0.00NS EA 408
    rs1383468551,2
    --96151109(+) CCTTTA/GCCTCC 1 -- us2k10--------
    rs1409608781,2
    --96151171(+) TCAAAA/GTATAT 1 -- us2k10--------
    rs14750891,2
    C,F,A,H--96151208(+) AATAGT/CAATTG 1 -- us2k134Minor allele frequency- C:0.11EA NA NS WA CSA 4388
    rs21810661,2
    C,F,O,A,H--96151250(+) TCTGCC/TTGGGA 1 -- us2k119Minor allele frequency- T:0.39EA NA NS WA 1412
    rs1501900171,2
    --96151298(+) TATTTA/CAAGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TCL1B (96152754 - 96158980 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TCL1B: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TCL1B
    DNA2.0 Custom Variant and Variant Library Synthesis for TCL1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603769    OMIM disorders: --

    5 diseases for TCL1B:    About MalaCards
    t-cell leukemia    prolymphocytic leukemia    leukemia    lymphoblastic leukemia
    breast cancer


    TCL1B for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TCL1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 82.9 11 10851082 (3), 11607815 (2), 10588720 (1), 11752899 (1) (see all 5)
    leukemogenesis 74.7 3 10851082 (1), 10344735 (1)
    lymphoma 45.8 4 10851082 (1), 11607815 (1)

    Genetic Association Database (GAD): TCL1B
    Human Genome Epidemiology (HuGE) Navigator: TCL1B (1 document)

    Export disorders for TCL1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCL1B gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with TCL1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes. (PubMed id 10077617)1, 2, 3, 9 Pekarsky Y.... Croce C.M. (1999)
    2. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PubMed id 11707444)1, 2, 9 Laine J.... Noguchi M. (2002)
    3. Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus. (PubMed id 10344735)1, 2, 9 Sugimoto J.... Isobe M. (1999)
    4. The protooncogene TCL1 is an Akt kinase coactivator. (PubMed id 10983986)1, 2, 9 Laine J....Noguchi M. (2000)
    5. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    6. Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia. (PubMed id 10851082)1, 9 Saitou M....Isobe M. (2000)
    7. The role of TCL1 in human T-cell leukemia. (PubMed id 11607815)1, 9 Pekarsky Y....Croce C.M. (2001)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Genome-wide associations and functional genomic studi es of musculoskeletal adverse events in women receiving aromatase inhibitors. (PubMed id 20876420)4 Ingle J.N....Weinshilboum R.M. (2010)
    10. Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clini cal implications. (PubMed id 20228224)1 Badve S....Nakshatri H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9623 HGNC: 11649 AceView: TCL1BandTCL6 Ensembl:ENSG00000213231 euGenes: HUgn9623
    ECgene: TCL1B Kegg: 9623 H-InvDB: TCL1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCL1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TCL1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCL1B gene:
    Search GeneIP for patents involving TCL1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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