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Aliases for TCL1B Gene

Aliases for TCL1B Gene

  • T-Cell Leukemia/Lymphoma 1B 2 3 5
  • Syncytiotrophoblast-Specific Protein 3 4
  • Oncogene TCL-1B 3 4
  • SYN-1 3 4
  • T-Cell Lymphoma/Leukemia 1B 3
  • TCL1/MTCP1-Like Protein 1 4
  • TCL1/ MTCP1-Like 1 3
  • Oncogene TCL1B 4
  • TCL1 4
  • TML1 3

External Ids for TCL1B Gene

Previous GeneCards Identifiers for TCL1B Gene

  • GC14P093628
  • GC14P089969
  • GC14P094118
  • GC14P094142
  • GC14P095198
  • GC14P095222
  • GC14P096152
  • GC14P076338

Summaries for TCL1B Gene

GeneCards Summary for TCL1B Gene

TCL1B (T-Cell Leukemia/Lymphoma 1B) is a Protein Coding gene. Diseases associated with TCL1B include t-cell leukemia and leukemia. Among its related pathways are PI3K-Akt signaling pathway. An important paralog of this gene is MTCP1.

UniProtKB/Swiss-Prot for TCL1B Gene

  • Enhances the phosphorylation and activation of AKT1 and AKT2.

Gene Wiki entry for TCL1B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCL1B Gene

Genomics for TCL1B Gene

Regulatory Elements for TCL1B Gene

Genomic Location for TCL1B Gene

Chromosome:
14
Start:
95,686,417 bp from pter
End:
95,692,643 bp from pter
Size:
6,227 bases
Orientation:
Plus strand

Genomic View for TCL1B Gene

Genes around TCL1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCL1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCL1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCL1B Gene

Proteins for TCL1B Gene

  • Protein details for TCL1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95988-TCL1B_HUMAN
    Recommended name:
    T-cell leukemia/lymphoma protein 1B
    Protein Accession:
    O95988
    Secondary Accessions:
    • A6NEK7
    • Q6IAR7
    • Q9UBQ4

    Protein attributes for TCL1B Gene

    Size:
    128 amino acids
    Molecular mass:
    14846 Da
    Quaternary structure:
    • Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3.
    Miscellaneous:
    • Activated in chronic T-cell leukemias (T-CLL) carrying rearrangements of the 14q32.1 region.

neXtProt entry for TCL1B Gene

Proteomics data for TCL1B Gene at MOPED

Post-translational modifications for TCL1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCL1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TCL1B Gene

Domains & Families for TCL1B Gene

Protein Domains for TCL1B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TCL1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95988

UniProtKB/Swiss-Prot:

TCL1B_HUMAN :
  • Belongs to the TCL1 family.
Family:
  • Belongs to the TCL1 family.
genes like me logo Genes that share domains with TCL1B: view

No data available for Gene Families for TCL1B Gene

Function for TCL1B Gene

Molecular function for TCL1B Gene

GENATLAS Biochemistry:
T cell leukemia transcript 1b,14kDa,highly similar to TCL1A,with the same pattern of low expression in normal bone marrow and peripheral lymphocytes but activated in T cell leukemias by rearrangements of 14q32.1 region
UniProtKB/Swiss-Prot Function:
Enhances the phosphorylation and activation of AKT1 and AKT2.
genes like me logo Genes that share phenotypes with TCL1B: view

Animal Model Products

CRISPR Products

miRNA for TCL1B Gene

miRTarBase miRNAs that target TCL1B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCL1B Gene

Localization for TCL1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCL1B Gene COMPARTMENTS Subcellular localization image for TCL1B gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TCL1B Gene

Pathways & Interactions for TCL1B Gene

SuperPathways for TCL1B Gene

Superpath Contained pathways
1 PI3K-Akt signaling pathway
genes like me logo Genes that share pathways with TCL1B: view

Pathways by source for TCL1B Gene

1 KEGG pathway for TCL1B Gene

SIGNOR curated interactions for TCL1B Gene

Activates:

Gene Ontology (GO) - Biological Process for TCL1B Gene

None

Drugs & Compounds for TCL1B Gene

No Compound Related Data Available

Transcripts for TCL1B Gene

Unigene Clusters for TCL1B Gene

T-cell leukemia/lymphoma 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCL1B Gene

No ASD Table

Relevant External Links for TCL1B Gene

GeneLoc Exon Structure for
TCL1B
ECgene alternative splicing isoforms for
TCL1B

Expression for TCL1B Gene

mRNA expression in normal human tissues for TCL1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCL1B Gene

This gene is overexpressed in Testis (x21.1), Whole Blood (x9.2), and Spleen (x7.6).

SOURCE GeneReport for Unigene cluster for TCL1B Gene Hs.632346

mRNA Expression by UniProt/SwissProt for TCL1B Gene

O95988-TCL1B_HUMAN
Tissue specificity: Expressed in a variety of tissues including placenta and testis.
genes like me logo Genes that share expression patterns with TCL1B: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TCL1B Gene

Orthologs for TCL1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCL1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCL1B 35
  • 99.22 (n)
  • 99.22 (a)
TCL1B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCL1B 36
  • 48 (a)
OneToOne
TCL1B 35
  • 68.2 (n)
  • 50.46 (a)
dog
(Canis familiaris)
Mammalia TCL1B 35
  • 72.92 (n)
  • 57.81 (a)
mouse
(Mus musculus)
Mammalia Tcl1b1 36
  • 34 (a)
OneToMany
Tcl1b2 36
  • 28 (a)
OneToMany
Tcl1b3 36
  • 30 (a)
OneToMany
Tcl1b4 36
  • 32 (a)
OneToMany
Tcl1b5 36
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
OneToMany
Species with no ortholog for TCL1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCL1B Gene

ENSEMBL:
Gene Tree for TCL1B (if available)
TreeFam:
Gene Tree for TCL1B (if available)

Paralogs for TCL1B Gene

Paralogs for TCL1B Gene

(2) SIMAP similar genes for TCL1B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TCL1B Gene

genes like me logo Genes that share paralogs with TCL1B: view

Variants for TCL1B Gene

Sequence variations from dbSNP and Humsavar for TCL1B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1064017 - 95,690,850(+) ACCCC(A/G)GGAGG reference, missense
rs710301 -- 95,692,475(+) ACACC(A/G)GAGCC utr-variant-3-prime
rs2763879 -- 95,686,340(+) gcccc(A/C)actgc upstream-variant-2KB
rs1743523 -- 95,687,550(+) ttccc(A/C)aaata intron-variant
rs1743524 -- 95,687,820(+) ggtgg(C/T)ggacg intron-variant

Variation tolerance for TCL1B Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.57; 88.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCL1B Gene

HapMap Linkage Disequilibrium report
TCL1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCL1B Gene

Disorders for TCL1B Gene

MalaCards: The human disease database

(2) MalaCards diseases for TCL1B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
leukemia
- elite association - COSMIC cancer census association via MalaCards
Search TCL1B in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCL1B

Genetic Association Database (GAD)
TCL1B
Human Genome Epidemiology (HuGE) Navigator
TCL1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCL1B
genes like me logo Genes that share disorders with TCL1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCL1B Gene

Publications for TCL1B Gene

  1. Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes. (PMID: 10077617) Pekarsky Y. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23 67
  2. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PMID: 11707444) Laine J. … Noguchi M. (J. Biol. Chem. 2002) 3 23
  3. The role of TCL1 in human T-cell leukemia. (PMID: 11607815) Pekarsky Y. … Croce C.M. (Oncogene 2001) 3 23
  4. The protooncogene TCL1 is an Akt kinase coactivator. (PMID: 10983986) Laine J. … Noguchi M. (Mol. Cell 2000) 3 23
  5. Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia. (PMID: 10851082) Saitou M. … Isobe M. (Oncogene 2000) 3 23

Products for TCL1B Gene

Sources for TCL1B Gene

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