TCL1B Gene
protein-coding GIFtS : 51
GCID: GC14 P096152
T-cell leukemia/lymphoma 1B
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Aliasesfor TCL1B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases T-Cell Leukemia/Lymphoma 1B 1 2 T-Cell Lymphoma/Leukemia 1B2 TML11 2 5 TCL1/ MTCP1-Like 12 Oncogene TCL-1B2 3 TCL13 Syncytiotrophoblast-Specific Protein2 3 Oncogene TCL1B3 SYN-12 3 TCL1/MTCP1-Like Protein 13 T-Cell Leukemia/Lymphoma Protein 1B2
Export aliases for TCL1B gene to outside databases Previous GC identifers: GC14P093628 GC14P089969 GC14P094118 GC14P094142 GC14P095198 GC14P095222 GC14P076338
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Summariesfor TCL1B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: TCL1B_HUMAN, O95988 Function : Enhances the phosphorylation and activation of AKT1 and AKT2Gene Wiki entry for TCL1B
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Genomic Viewsfor TCL1B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000014.8 NC_018925.1 NT_026437.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TCL1B gene promoter: AP-2rep p53 AML1a POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) Nkx2-5 POU3F2 Nkx5-1 MZF-1 S8 Other transcription factors Search SABiosciences Chromatin IP Primers for TCL1B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCL1B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q32.1 Ensembl cytogenetic band: 14q32.13 HGNC cytogenetic band: 14q32.1 TCL1B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14P096152: view genomic region
(about GC identifiers )
Start:
96,152,754 bp from pter
End:
96,158,967 bp from pter
Size:
6,214 bases
Orientation:
plus strand
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Proteinsfor TCL1B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TCL1B_HUMAN, O95988 (See
protein sequence )Recommended Name: T-cell leukemia/lymphoma protein 1B Size : 128 amino acids; 14846 Da
Subunit : Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3
Miscellaneous : Activated in chronic T-cell leukemias (T-CLL) carrying rearrangements of the 14q32.1 region
Secondary accessions : A6NEK7 Q6IAR7 Q9UBQ4Explore the universe of human proteins at neXtProt for TCL1B: NX_O95988 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O95988 TCL1B Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_004909.1 ENSEMBL proteins: ENSP00000343223 Human Recombinant Protein Products: TCL1B Antibody Products: Assay Products for TCL1B:
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Protein
Domains / Familiesfor TCL1B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TCL1B for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry O95988 ProtoNet protein and cluster: O95988
1 Blocks protein family : IPB004832 TCL1/MTCP1 family UniProtKB/Swiss-Prot: TCL1B_HUMAN, O95988 Similarity : Belongs to the TCL1 family
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Functionfor TCL1B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TCL1B_HUMAN, O95988 Function : Enhances the phosphorylation and activation of AKT1 and AKT2
Genatlas biochemistry entry for TCL1B : T cell leukemia transcript 1b,14kDa,highly similar to TCL1A,with the same pattern of low expression in normal bone marrow and peripheral lymphocytes but activated in T cell leukemias by rearrangements of 14q32.1 region Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TCL1B (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TCL1B (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TCL1B (NM_004918 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCL1B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TCL1B
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCL1B
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Pathways & Interactionsfor TCL1B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCL1B STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)4 Interacting proteins for TCL1B (O95988 2 , 3 ENSP00000343223 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor TCL1B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TCL1B Search CenterWatch for drugs/clinical trials and news about TCL1B
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Transcriptsfor TCL1B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TCL1B gene (2 alternative transcripts): NM_199206.2 NM_004918.3 Unigene Cluster for TCL1B:
T-cell leukemia/lymphoma 1B Hs.632346 [show with all ESTs ] Unigene Representative Sequence: AB018563 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000340722 (uc001yez.3 ) ENST00000464815 (uc001yfa.3 ) ENST00000556665 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TCL1B (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TCL1B (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TCL1B (NM_004918 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCL1B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TCL1B
Additional cDNA sequence: AB018563.1 AF110466.1 AF137027.1 BC041616.1 BC051000.1 CR457087.1
5 DOTS entries : DT.304976 DT.100726221
DT.92417349 DT.121634051 DT.95358784 24/162 AceView cDNA sequences (see all 162 ):
BX161462 BF589188 AF195820 BX110858 AB035342 NM_020553 AI219070 BC041616 BC041075 NM_012468 BF511117 AB035343 NM_020552 BC051000 BQ055042 CR600897 AB035341 H03864 NM_020550 AW044670 BQ061440 AI498415 BQ228977 NM_014418 GeneLoc Exon Structure
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Expression for TCL1B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TCL1B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCCAGATTGA
About this image TCL1B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Ovary Antral Follicle Secondary Oocyte Female Gametocytes, Germ Cells Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TCL1B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TCL1B SOURCE GeneReport for Unigene cluster: Hs.632346 UniProtKB/Swiss-Prot: TCL1B_HUMAN, O95988 Tissue specificity : Expressed in a variety of tissues including placenta and testis SABiosciences Custom PCR Arrays for TCL1B Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TCL1BBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat TCL1B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TCL1B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TCL1B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCL1B
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Orthologsfor TCL1B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
--
ENSEMBL Gene Tree for TCL1B (if available)TreeFam Gene Tree for TCL1B (if available)
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Paralogsfor TCL1B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TCL1B gene MTCP1 2 TCL1A 2 2 SIMAP similar genes for TCL1B using alignment to 1 protein entry: TCL1B_HUMAN :MTCP1 TCL1A
TCL1B for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for TCL1B PGOHUM00000235610
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Genomic Variantsfor TCL1B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 14 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TCL1B (96152754 - 96158967 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TCL1B: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TCL1B
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Disorders
/ Diseasesfor TCL1B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TCL1B for disorders About GeneDecksing
OMIM gene information: 603769
OMIM disorders : --7 diseases for TCL1B : About MalaCards leukemia/lymphoma leukemia t-cell leukemia leukemia/lymphoma, t-cell prolymphocytic leukemia lymphoblastic leukemia breast cancer 3 Novoseek disease relationships for TCL1B gene About this table
Human Genome Epidemiology (HuGE) Navigator: TCL1B (1 document)Export disorders for TCL1B gene to outside databases
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Publicationsfor TCL1B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TCL1B gene, integrated from 9 sources (see all 19 ): (articles sorted by number of sources associating them with TCL1B) Utopia : connect your pdf to the dynamic world of online information
Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes. (PubMed id 10077617) 1 , 2 , 3, 9 Pekarsky Y.... Croce C.M. (1999) Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PubMed id 11707444) 1 , 2 , 9 Laine J.... Noguchi M. (2002) Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus. (PubMed id 10344735) 1 , 2 , 9 Sugimoto J.... Isobe M. (1999) The protooncogene TCL1 is an Akt kinase coactivator. (PubMed id 10983986) 1 , 2 , 9 Laine J....Noguchi M. (2000) Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia. (PubMed id 10851082) 1 , 9 Saitou M....Isobe M. (2000) The role of TCL1 in human T-cell leukemia. (PubMed id 11607815) 1 , 9 Pekarsky Y....Croce C.M. (2001) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clini cal implications. (PubMed id 20228224) 1 Badve S....Nakshatri H. (2010) Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603) 1 Flachsbart F....Nebel A. (2010) Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. (PubMed id 19229105) 1 Xiong H....Zhang Z. (2009)
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External Searches for TCL1B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TCL1B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TCL1B gene
(According to HUGE )
About This Section --
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Specialized Databases showing TCL1B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for TCL1B gene: Search GeneIP for patents involving TCL1B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TCL1B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs Browse OriGene 29mer shRNA kits in GFP-retroviral vector OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TCL1B OriGene Protein Over-expression Lysate for TCL1B Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TCL1B Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TCL1B OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TCL1B Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for TCL1B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TCL1B OriGene Custom Protein Services for TCL1B OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCL1B QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TCL1B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCL1B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TCL1B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TCL1B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TCL1B
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TCL1B Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCL1B
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TCL1B
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