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TCL1A Gene

protein-coding GIFtS: 63

GC14M095246

T-cell leukemia/lymphoma 1A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
TCL-1 ^³
TCL1 ^¹, ², ³, ⁵

Descriptions
Oncogene TCL1 ^³
Protein p14 TCL1 ^³
T-cell leukemia/lymphoma 1A ^²
T-cell lymphoma-1 ^²
T-cell lymphoma-1A ^²

External Ids
HGNC: 11648¹
Entrez Gene: 8115²
UniProtKB: P56279³
Ensembl: ENSG00000100721⁷

Search outside databases for aliases for TCL1A gene

Previous GC identifers: GC14M093687 GC14M089992 GC14M094166

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TCL1A_HUMAN, P56279

Function: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear

translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential

and promotes cell survival

Gene Wiki entry for TCL1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TCL1A gene

Entrez Gene cytogenetic band: 14q32.1 Ensembl cytogenetic band: 14q32.13 HGNC cytogenetic band: 14q32.1

TCL1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M095246: (about GC identifiers)

Start:	95,246,057 bp from pter
End:	95,250,286 bp from pter
Size:	4,230 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TCL1A_HUMAN, P56279 (See protein sequence)

Recommended Name: T-cell leukemia/lymphoma protein 1A

Size: 114 amino acids; 13460 Da

Subunit: Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the

interaction has no effect on PNPT1 exonuclease activity

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Microsome. Endoplasmic

reticulum. Note=Microsomal fraction

PDB structures from and Proteopedia :

1JSG (3D)

Secondary accessions: Q6IBK7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001092195.1 NP_068801.1

ENSEMBL proteins:

ENSP00000385036 ENSP00000216612

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Tcl1)
	Human Recombinant Proteins from Abnova (TCL1A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005792	microsome	IEA	--

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Antibodies for TCL1A:

	Invitrogen Antibodies for TCL1A
	Millipore Mono- and Polyclonal Antibodies for the study of TCL1A
	Sigma-Aldrich Antibodies for TCL1A
	R&D Systems Antibodies for TCL1A
	Antibodies from Abcam (Tcl1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TCL1A)
	Novus Biologicals Antibodies for TCL1A

Assays for TCL1A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P56279

ProtoNet protein and cluster: P56279

1 Blocks protein family: IPB004832 TCL1/MTCP1 family

UniProtKB/Swiss-Prot: TCL1A_HUMAN, P56279

Similarity: Belongs to the TCL1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TCL1A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TCL1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001098725

Applied Biosystems Silencer® siRNAs for TCL1A

Sigma-Aldrich siRNA for TCL1A

Sigma-Aldrich shRNA Panels and shRNA for TCL1A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TCL1A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001098725
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001098725
untagged cDNA clones in CMV expression vector (see all 2): NM_001098725

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001098725

UniProtKB/Swiss-Prot: TCL1A_HUMAN, P56279

Function: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear

translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential

and promotes cell survival

Genatlas biochemistry entry for TCL1A:

T cell leukemia,transcript 1a,14kDa,normally expressed in pre-B cells and immature IgM expressing B

cells and in early T cell progenitors with very low levels in bone marrow and peripheral

lymphocytes activated in T cell leukemia and lymphoma by rearrangements of the 14q32.1 region

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Tcl1):

reproductive system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11707444

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for TCL1A (Your Favorite Gene powered by Ingenuity)

Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency

GeneDecks TCL1A for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for TCL1A

5/14 Interacting proteins for TCL1A (ENSP00000216612³ P56279²) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALCOCO2	Q13137²	MINT-67657
HIST3H2A	Q7L7L0²	MINT-67415
AKT1	ENSP00000270202³	STRING (score=.998)
AKT2	ENSP00000309428³	STRING (score=.993)
CRTC2	ENSP00000305873³	STRING (score=.961)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	TAS	7809072

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TCL1A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TCL1A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TCL1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001098725

Sigma-Aldrich siRNA for TCL1A

Sigma-Aldrich shRNA Panels and shRNA for TCL1A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001098725 NM_021966

REFSEQ mRNAs for TCL1A gene (2 alternative transcripts):

NM_001098725.1 NM_021966.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001098725 NM_021966

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001098725
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001098725
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001098725

Additional cDNA sequence:

BC003574.1 BC005831.2 BC009502.2 BC009891.2 BC014024.1 CR456796.1 CR597499.1 CR602539.1

CR607470.1 CR614970.1 X82240.1

6 DOTS entries:

DT.455316 DT.97847936 DT.100719918 DT.40106305 DT.92447322 DT.97847934

24/315 AceView cDNA sequences (see all 315 ):

AW733068 BE514042 CR597499 BM927612 BM909407 BE270847 BI225265 BX443335

BQ061874 CR614970 BQ060857 AI950484 BU151153 BQ056518 BQ063405 BX371316

BE268242 W02638 BQ061897 BQ061232 BF976050 BE270193 BG754764 BM470088

highest scoring ESTs for TCL1A:

X82240 AA321269 AA362309 AL560722 AW328037 AW404960 AW405079 AW406115 AW406275 AW406506

Unigene Cluster for TCL1A:

T-cell leukemia/lymphoma 1A

Hs.2484 [show with all ESTs]

Unigene Representative Sequence: BQ057554

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TCL1A (see all 7 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b
SP1:							-		-		-						-
SP2:
SP3:							-		-		-						-
SP4:							-		-		-						-		-		-
SP5:											-						-

About this scheme

ECgene alternative splicing isoforms for TCL1A

2 Ensembl transcripts including schematic representations:

ENST00000402399 ENST00000216612

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TCL1A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TCL1A

¹ / ² / ³

5 probe-sets matching TCL1A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39318_at²^{, 3}	U133-A	1	1.00	1.00	1.00	1.00	X82240	1.00	1.00	1.00	1
39318_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X82240	1.00	1.00	1.00	1
209995_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC003574	0.80	1.00	0.91	1
39318_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209995_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TCL1A for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AATACTTTTT

SOURCE GeneReport for Unigene cluster: Hs.2484
UniProtKB/Swiss-Prot: TCL1A_HUMAN, P56279
Tissue specificity: Restricted in the T-cell lineage to immature thymocytes and activated
peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TCL1A gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	TCL1A¹	--	T-cell leukemia/lymphoma 1A	99.12(n) 99.12(a)	741380 XM_001154719.1 XP_001154719.1
cow (Bos taurus)	TCL1A¹	--	T-cell leukemia/lymphoma 1A	77.18(n) 64.86(a)	506540 XM_583000.3 XP_583000.3
rat (Rattus norvegicus)	Tcl1a¹	--	T-cell leukemia/lymphoma 1A	68.69(n) 59.6(a)	690575 XM_001074847.1 XP_001074847.1
mouse (Mus musculus)	Tcl1^{1, 5}	12 (52.00 cM)⁵	T-cell lymphoma breakpoint 1^{1, 5}	68.35(n)¹ 57.58(a)¹	21432¹ NM_009337.2¹ NP_033363.1¹ AF031956⁵ AK149361⁵ (see all 11)

About this table Species with no ortholog for TCL1A

ENSEMBL Gene Tree for TCL1A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TCL1A gene

MTCP1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/30 NCBI SNPs in TCL1A are shown (see all 30 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 38)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1957937^1,2	A,C,F,H	95251113(+)	`GCACAA/TTGAAA`	2	--	ng3¹		12	EU EA WA NA	1190
	rs728739^1,2	A,C,F,H	95251815(-)	`TATTCT/CCAGAA`	2	--	ng3¹		8	EU EA WA NA	782
	rs11846938^1,2	A,C,F,H	95250438(+)	`GCAGCT/GCCTGG`	2	--	ng3¹		7	NA EU EA WA	520
	rs17093294^1,2	C,F,H	95248441(+)	`GACGAC/TGTCTT`	2	V/I	mis¹ ese³		12	NA EU EA WA	1048
	rs2887399^1,2	C,F,H	95250448(+)	`GGAACG/TCAGAC`	2	--	ng3¹		4	EU EA WA	416
	rs1123245^1,2	C,F,H	95251278(-)	`GATGTC/TCTCAT`	2	--	ng3¹		4	EU EA WA	420
	rs17093285^1,2	C,F,H	95245957(+)	`CTCCAA/GTGGTT`	2	--	ng5¹		16	NA EU EA WA	1472
	rs17093288^1,2	C,F,H	95246026(+)	`ATTGTA/GGTCCC`	2	--	ng5¹		11	NA EU EA WA	978
	rs1984968^1,2	C,F,H	95251335(-)	`GGGAAT/CTAGGC`	2	--	ng3¹		17	NA EA EU WA	1686
	rs1984967^1,2	C,F,H	95251725(-)	`GCTGGG/ATCAGT`	2	--	ng3¹		4	EU EA WA	418

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HapMap Linkage Disequilibrium images for TCL1A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 186960

UniProtKB/Swiss-Prot: TCL1A_HUMAN, P56279

Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL).

Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that

involves the T-cell receptor alpha/delta locuses

10/27 Novoseek disease relationships for TCL1A gene (see all 27 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia prolymphocytic	93.71	14	9691281 (1), 8634440 (1), 9657733 (1), 10959629 (1) (see all 12)
leukemia t-cell	90.10	45	11607815 (4), 11710897 (2), 12011454 (2), 10077617 (2) (see all 30)
lymphocytic leukemia t-cell chronic	81.53	3	9520462 (1), 10197596 (1)
ataxia telangiectasia	71.48	7	8634440 (1), 11752899 (1), 11297767 (1), 7662982 (1) (see all 6)
leukemia lymphocytic chronic	63.41	9	16341048 (2), 17178851 (1), 12011454 (1), 15661260 (1) (see all 7)
lymphoma	61.68	43	11304575 (7), 10792782 (6), 19147787 (3), 16978196 (2) (see all 15)
leukemia	58.96	13	9520462 (2), 12011454 (1), 12576313 (1), 11054065 (1) (see all 11)
lymphoma aids-related	57.96	2	10449776 (1), 11304575 (1)
leukemogenesis	57.55	4	10851082 (1), 10344735 (1), 11707444 (1), 17846228 (1)
lymphoma b-cell	56.10	9	16978196 (3), 10786666 (2), 17260020 (1), 15586235 (1) (see all 5)

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1 PharmGKB disease relationship for TCL1A gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

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Genatlas disease: TCL1A

chronic lymphocytic leukemia (T-CLL) associated breakpoint 1,with inversion inv(14) (q11;q32) and

translocations t(14;14)(q11;q32),t(7;14)(q35;q32)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/105 PubMed articles for TCL1A gene (see all 105 ):

Identification of the TCL1 gene involved in T-cell malignancies. (PubMed id 7809072)^{1, 2, 3, 4} Virgilio L....Russo G. (1994)
The protooncogene TCL1 is an Akt kinase coactivator. (PubMed id 10983986)^{1, 3, 4} Laine J....Noguchi M. (2000)
Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PubMed id 11707444)^{1, 3, 4} Laine J....Noguchi M. (2002)
Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology. (PubMed id 9519406)^{1, 3, 4} Hoh F.... van Tilbourgh H. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Characterization and localization of the TCL-1 oncogene product. (PubMed id 7987816)^{3, 4} Fu T.-B....Croce C.M. (1994)
Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient. (PubMed id 2783489)^{2, 3} Russo G....Croce C.M. (1989)
Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. (PubMed id 10716693)^{1, 4} Pekarsky Y....Croce C.M. (2000)
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia. (PubMed id 9738977)^{1, 3} Takizawa J....Seto M. (1998)
Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1. (PubMed id 11839817)^{1, 4} Kunstle G....Noguchi M. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 8115	HGNC: 11648	AceView: TCL1A	Ensembl:ENSG00000100721	euGenes: HUgn8115
ECgene: TCL1A	H-InvDB: TCL1A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for TCL1A	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TCL1A
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for TCL1A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TCL1A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TCL1A		Antibodies for TCL1A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TCL1A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TCL1A)
	Antibodies (TCL1A)
	Chimera RNAi (TCL1A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (Tcl1)

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Search Tocris compounds for TCL1A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TCL1A

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TCL1A Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for TCL1A

Summaries
for TCL1A

Genomic Location
for TCL1A

Proteins
for TCL1A

Protein Domains/
Families
for TCL1A

Gene Function
for TCL1A

Pathways & Interactions
for TCL1A

Drugs & Compounds
for TCL1A

Transcripts
for TCL1A

Expression
for TCL1A

Orthologs
for TCL1A

Paralogs
for TCL1A

SNPs/Variants
for TCL1A

Disorders & Mutations
for TCL1A

Medical News
for TCL1A

Publications
for TCL1A

Search for TCL1A

Genome Databases showing TCL1A

Other Databases showing TCL1A

Specialized Databases showing TCL1A

Licensable Technologies
for TCL1A

Services
for TCL1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TCL1A Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor TCL1A

Summariesfor TCL1A

Genomic Locationfor TCL1A

Proteinsfor TCL1A

Protein Domains/Familiesfor TCL1A

Gene Functionfor TCL1A

Pathways & Interactionsfor TCL1A

Drugs & Compoundsfor TCL1A

Transcriptsfor TCL1A

Expression for TCL1A

Orthologsfor TCL1A

Paralogsfor TCL1A

SNPs/Variantsfor TCL1A

Disorders & Mutationsfor TCL1A

Medical Newsfor TCL1A

Publicationsfor TCL1A

Search for TCL1A

Genome Databases showing TCL1A

Other Databases showing TCL1A

Specialized Databases showing TCL1A

Licensable Technologiesfor TCL1A

Servicesfor TCL1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TCL1A

Summaries
for TCL1A

Genomic Location
for TCL1A

Proteins
for TCL1A

Protein Domains/
Families
for TCL1A

Gene Function
for TCL1A

Pathways & Interactions
for TCL1A

Drugs & Compounds
for TCL1A

Transcripts
for TCL1A

Expression
for TCL1A

Orthologs
for TCL1A

Paralogs
for TCL1A

SNPs/Variants
for TCL1A

Disorders & Mutations
for TCL1A

Medical News
for TCL1A

Publications
for TCL1A

Licensable Technologies
for TCL1A

Services
for TCL1A