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Aliases for TCL1A Gene

Aliases for TCL1A Gene

  • T-Cell Leukemia/Lymphoma 1A 2 3
  • TCL1 3 4 6
  • Protein P14 TCL1 3 4
  • Oncogene TCL-1 3 4
  • Oncogene TCL1 3 4
  • T-Cell Leukemia/Lymphoma Protein 1A 3
  • T-Cell Lymphoma-1 3

External Ids for TCL1A Gene

Summaries for TCL1A Gene

Entrez Gene Summary for TCL1A Gene

  • Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

GeneCards Summary for TCL1A Gene

TCL1A (T-Cell Leukemia/Lymphoma 1A) is a Protein Coding gene. Diseases associated with TCL1A include t-cell leukemia and chronic lymphocytic leukemia. Among its related pathways are PI3K-Akt signaling pathway and PI3K / Akt Signaling. An important paralog of this gene is MTCP1.

UniProtKB/Swiss-Prot for TCL1A Gene

  • Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.

Gene Wiki entry for TCL1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCL1A Gene

Genomics for TCL1A Gene

Genomic Location for TCL1A Gene

Start:
95,709,967 bp from pter
End:
95,714,196 bp from pter
Size:
4,230 bases
Orientation:
Minus strand

Genomic View for TCL1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCL1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCL1A Gene

Regulatory Elements for TCL1A Gene

Proteins for TCL1A Gene

  • Protein details for TCL1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56279-TCL1A_HUMAN
    Recommended name:
    T-cell leukemia/lymphoma protein 1A
    Protein Accession:
    P56279
    Secondary Accessions:
    • Q6IBK7

    Protein attributes for TCL1A Gene

    Size:
    114 amino acids
    Molecular mass:
    13460 Da
    Quaternary structure:
    • Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.

    Three dimensional structures from OCA and Proteopedia for TCL1A Gene

neXtProt entry for TCL1A Gene

Proteomics data for TCL1A Gene at MOPED

Post-translational modifications for TCL1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCL1A Gene

Domains for TCL1A Gene

Protein Domains for TCL1A Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TCL1A_HUMAN
Family:
  • Belongs to the TCL1 family.:
    • P56279
genes like me logo Genes that share domains with TCL1A: view

No data available for Gene Families for TCL1A Gene

Function for TCL1A Gene

Molecular function for TCL1A Gene

GENATLAS Biochemistry: T cell leukemia,transcript 1a,14kDa,normally expressed in pre-B cells and immature IgM expressing B cells and in early T cell progenitors with very low levels in bone marrow and peripheral lymphocytes activated in T cell leukemia and lymphoma by rearrangements of the 14q32.1 region
UniProtKB/Swiss-Prot Function: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.

Gene Ontology (GO) - Molecular Function for TCL1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TCL1A: view
genes like me logo Genes that share phenotypes with TCL1A: view

Animal Models for TCL1A Gene

MGI Knock Outs for TCL1A:

miRNA for TCL1A Gene

miRTarBase miRNAs that target TCL1A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TCL1A Gene

Localization for TCL1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCL1A Gene

Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Note=Microsomal fraction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCL1A Gene COMPARTMENTS Subcellular localization image for TCL1A gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TCL1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005783 endoplasmic reticulum IEA --
GO:0005938 cell cortex IEA --
GO:0045120 pronucleus IEA --
genes like me logo Genes that share ontologies with TCL1A: view

Pathways for TCL1A Gene

genes like me logo Genes that share pathways with TCL1A: view

Pathways by source for TCL1A Gene

1 Cell Signaling Technology pathway for TCL1A Gene
1 KEGG pathway for TCL1A Gene

Gene Ontology (GO) - Biological Process for TCL1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development TAS 7809072
GO:0019827 stem cell maintenance IEA --
genes like me logo Genes that share ontologies with TCL1A: view

Compounds for TCL1A Gene

(2) Novoseek inferred chemical compound relationships for TCL1A Gene

Compound -log(P) Hits PubMed IDs
threonine 20.9 1
serine 4.42 1
genes like me logo Genes that share compounds with TCL1A: view

Transcripts for TCL1A Gene

Unigene Clusters for TCL1A Gene

T-cell leukemia/lymphoma 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCL1A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: - - - -
SP2:
SP3: - - - -
SP4: - - - - - -
SP5: - -
SP6: - - -
SP7:

Relevant External Links for TCL1A Gene

GeneLoc Exon Structure for
TCL1A
ECgene alternative splicing isoforms for
TCL1A

Expression for TCL1A Gene

mRNA expression in normal human tissues for TCL1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCL1A Gene

This gene is overexpressed in Spleen (7.9) and Whole Blood (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TCL1A Gene

SOURCE GeneReport for Unigene cluster for TCL1A Gene Hs.2484

mRNA Expression by UniProt/SwissProt for TCL1A Gene

P56279-TCL1A_HUMAN
Tissue specificity: Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation
genes like me logo Genes that share expressions with TCL1A: view

Orthologs for TCL1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCL1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCL1A 36
  • 99.12 (n)
  • 99.12 (a)
TCL1A 37
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCL1A 36
  • 77.18 (n)
  • 64.86 (a)
TCL1A 37
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCL1A 37
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcl1 36
  • 69.1 (n)
  • 59.37 (a)
Tcl1 16
Tcl1 37
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcl1a 36
  • 69.44 (n)
  • 61.46 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 44 (a)
OneToMany
Species with no ortholog for TCL1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCL1A Gene

ENSEMBL:
Gene Tree for TCL1A (if available)
TreeFam:
Gene Tree for TCL1A (if available)

Paralogs for TCL1A Gene

Paralogs for TCL1A Gene

Selected SIMAP similar genes for TCL1A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TCL1A: view

Variants for TCL1A Gene

Sequence variations from dbSNP and Humsavar for TCL1A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs728739 -- 95,715,725(-) TATTC(C/T)CAGAA upstream-variant-2KB
rs1122138 -- 95,713,905(+) AGGGG(A/C)TGCCC intron-variant
rs1123245 -- 95,715,188(-) GATGT(C/T)CTCAT upstream-variant-2KB
rs1951989 -- 95,715,937(+) TGAAC(A/G)TTCCA upstream-variant-2KB
rs1957936 -- 95,714,611(+) CGGGC(C/T)TGAGT upstream-variant-2KB

Relevant External Links for TCL1A Gene

HapMap Linkage Disequilibrium report
TCL1A

No data available for Structural Variations from Database of Genomic Variants (DGV) for TCL1A Gene

Disorders for TCL1A Gene

UniProtKB/Swiss-Prot

TCL1A_HUMAN
  • Note=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.

(3) University of Copenhagen DISEASES for TCL1A Gene

(27) Novoseek inferred disease relationships for TCL1A Gene

Disease -log(P) Hits PubMed IDs
leukemia prolymphocytic 93.1 12
leukemia t-cell 89.6 38
lymphocytic leukemia t-cell chronic 80.5 2
ataxia telangiectasia 69.6 6
leukemia lymphocytic chronic 65.1 8

Genatlas disease for TCL1A Gene

chronic lymphocytic leukemia (T-CLL) associated breakpoint 1,with inversion inv(14) (q11;q32) and translocations t(14;14)(q11;q32),t(7;14)(q35;q32)

Relevant External Links for TCL1A

Genetic Association Database (GAD)
TCL1A
Human Genome Epidemiology (HuGE) Navigator
TCL1A
genes like me logo Genes that share disorders with TCL1A: view

Publications for TCL1A Gene

  1. Identification of the TCL1 gene involved in T-cell malignancies. (PMID: 7809072) Virgilio L. … Russo G. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23
  2. Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology. (PMID: 9519406) Hoh F. … van Tilbourgh H. (Structure 1998) 3 4 23
  3. The protooncogene TCL1 is an Akt kinase coactivator. (PMID: 10983986) Laine J. … Noguchi M. (Mol. Cell 2000) 3 4 23
  4. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PMID: 11707444) Laine J. … Noguchi M. (J. Biol. Chem. 2002) 3 4 23
  5. Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia. (PMID: 9738977) Takizawa J. … Seto M. (Jpn. J. Cancer Res. 1998) 3 23

Products for TCL1A Gene

Sources for TCL1A Gene

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