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TCL1A Gene

protein-coding   GIFtS: 62
GCID: GC14M096177

T-Cell Leukemia/Lymphoma 1A

  See TCL1A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T-Cell Leukemia/Lymphoma 1A1 2     Protein P14 TCL12 3
TCL12 3 5     T-Cell Leukemia/Lymphoma Protein 1A2
Oncogene TCL-12 3     T-Cell Lymphoma-12
Oncogene TCL12 3     

External Ids:    HGNC: 116481   Entrez Gene: 81152   Ensembl: ENSG000001007217   OMIM: 1869605   UniProtKB: P562793   

Export aliases for TCL1A gene to outside databases

Previous GC identifers: GC14M093687 GC14M089992 GC14M094166 GC14M095246 GC14M076361


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCL1A Gene:
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in
which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor
(TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998
(PubMed 9520462)). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of
differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000
(PubMed 10983986)).(supplied by OMIM, Jul 2010)

GeneCards Summary for TCL1A Gene:
TCL1A (T-cell leukemia/lymphoma 1A) is a protein-coding gene. Diseases associated with TCL1A include urocanase deficiency, and leukemia/lymphoma, t-cell. An important paralog of this gene is MTCP1.

UniProtKB/Swiss-Prot: TCL1A_HUMAN, P56279
Function: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of
AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival

Gene Wiki entry for TCL1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCL1A gene promoter:
         GATA-3   STAT5A   NF-AT   S8   NF-AT4   NF-AT2   HSF2   NF-AT3   LyF-1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCL1A promoter sequence
   Search Chromatin IP Primers for TCL1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCL1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.1   Ensembl cytogenetic band:  14q32.13   HGNC cytogenetic band: 14q32.1

TCL1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCL1A gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M096177:  view genomic region     (about GC identifiers)

Start:
96,176,304 bp from pter      End:
96,180,533 bp from pter
Size:
4,230 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCL1A_HUMAN, P56279 (See protein sequence)
Recommended Name: T-cell leukemia/lymphoma protein 1A  
Size: 114 amino acids; 13460 Da
Subunit: Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has
no effect on PNPT1 exonuclease activity
1 PDB 3D structure from and Proteopedia for TCL1A:
1JSG (3D)    
Secondary accessions: Q6IBK7

Explore the universe of human proteins at neXtProt for TCL1A: NX_P56279

Explore proteomics data for TCL1A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TCL1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001092195.1  NP_068801.1  

    ENSEMBL proteins: 
     ENSP00000451506   ENSP00000450701   ENSP00000452028   ENSP00000450997   ENSP00000451973  
     ENSP00000451322   ENSP00000450496   ENSP00000385036  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004832 TCL1_MTCP1

    Graphical View of Domain Structure for InterPro Entry P56279

    ProtoNet protein and cluster: P56279

    1 Blocks protein domain: IPB004832 TCL1/MTCP1 family

    UniProtKB/Swiss-Prot: TCL1A_HUMAN, P56279
    Similarity: Belongs to the TCL1 family


    Find genes that share domains with TCL1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCL1A_HUMAN, P56279
    Function: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of
    AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival

         Genatlas biochemistry entry for TCL1A:
    T cell leukemia,transcript 1a,14kDa,normally expressed in pre-B cells and immature IgM expressing B cells and in
    early T cell progenitors with very low levels in bone marrow and peripheral lymphocytes activated in T cell
    leukemia and lymphoma by rearrangements of the 14q32.1 region

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16934922
         
    Find genes that share ontologies with TCL1A           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for TCL1A:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tcl1):
     reproductive system 

    Find genes that share phenotypes with TCL1A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tcl1tm1Rso for TCL1A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCL1A
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    hsa-mir-29b-3p (MIRT004510), hsa-mir-181b-5p (MIRT005106)

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    3 qRT-PCR Assays for microRNAs that regulate TCL1A:
    hsa-miR-3176 hsa-miR-3922-3p hsa-miR-3126-5p
    SwitchGear 3'UTR luciferase reporter plasmidTCL1A 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCL1A_HUMAN, P56279: Cytoplasm (By similarity). Nucleus (By similarity). Microsome. Endoplasmic reticulum.
    Note=Microsomal fraction
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol2
    nucleus2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005783endoplasmic reticulum IEA--
    GO:0005938cell cortex IEA--
    GO:0045120pronucleus IEA--

    Find genes that share ontologies with TCL1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TCL1A About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of Oct 3 4
    Selected targets of Oct 3 4
    2PI3K / Akt Signaling
    PI3K / Akt Signaling
    3PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway


    Find genes that share SuperPaths with TCL1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TCL1A
        PI3K / Akt Signaling



    1 Kegg Pathway  (Kegg details for TCL1A):
        PI3K-Akt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including TCL1A: 
              PI3K-AKT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TCL1A

    Selected Interacting proteins for TCL1A (P562792, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCOCO2Q131372, 3MINT-67657 I2D: score=6 
    HIST3H2AQ7L7L02, 3MINT-67415 I2D: score=4 
    AKT2P317513I2D: score=5 
    AKT3Q9Y2433I2D: score=5 
    AKT1P317493I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development TAS7809072
    GO:0019827stem cell maintenance IEA--

    Find genes that share ontologies with TCL1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCL1A

    2 Novoseek inferred chemical compound relationships for TCL1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 20.9 1 19344392 (1)
    serine 4.42 1 19344392 (1)



    Find genes that share compounds with TCL1A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TCL1A gene (2 alternative transcripts): 
    NM_001098725.1  NM_021966.2  

    Unigene Cluster for TCL1A:

    T-cell leukemia/lymphoma 1A
    Hs.2484  [show with all ESTs]
    Unigene Representative Sequence: NR_049726
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554012(uc001yfc.4) ENST00000556450 ENST00000557043 ENST00000554119
    ENST00000555886 ENST00000553467 ENST00000556156 ENST00000555202 ENST00000402399(uc001yfb.4)

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    hsa-miR-3176 hsa-miR-3922-3p hsa-miR-3126-5p
    SwitchGear 3'UTR luciferase reporter plasmidTCL1A 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    BC003574.1 BC005831.2 BC009502.2 BC009891.2 BC014024.1 CR456796.1 NR_049726.1 X82240.1 

    6 DOTS entries:

    DT.455316  DT.97847936  DT.100719918  DT.40106305  DT.92447322  DT.97847934 

    Selected AceView cDNA sequences (see all 315):

    BQ059785 BG759376 BQ056512 BQ882730 BQ059689 BE269938 BQ061897 BE396482 
    BM927621 BQ064150 BC014024 BF128815 BQ066787 BQ063070 BE267581 BU602054 
    BE513411 AW732980 BQ061994 BC005831 CR597499 BQ643245 BE268242 AW575375 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TCL1A (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
    SP1:                    -     -     -                 -                           
    SP2:                                                                              
    SP3:                    -     -     -                 -                           
    SP4:                    -     -     -                 -     -     -               
    SP5:                                -                 -                           


    ECgene alternative splicing isoforms for TCL1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCL1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATACTTTTT
    TCL1A Expression
    About this image


    TCL1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Mature B-Cells Peripheral Blood
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Secondary Oocyte Antral Follicle
             Secondary follicles
     
     Gonad
             Primordial Germ Cells Allantois
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Bone (Muscoskeletal System)
             Bone Marrow
    TCL1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCL1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2484

    UniProtKB/Swiss-Prot: TCL1A_HUMAN, P56279
    Tissue specificity: Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes.
    Preferentially expressed early in T- and B-lymphocyte differentiation

        Pathway & Disease-focused RT2 Profiler PCR Array including TCL1A: 
              PI3K-AKT Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCL1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TCL1A gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcl11 , 5 T cell lymphoma breakpoint 11, 5 69.1(n)1
    59.37(a)1
      12 (55.28 cM)5
    214321  NM_009337.31  NP_033363.11 
     1052167505 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    44(a)
    1 → many
    GL343528.1(421305-421616)


    ENSEMBL Gene Tree for TCL1A (if available)
    TreeFam Gene Tree for TCL1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCL1A gene
    MTCP12  TCL1B2  
    2 SIMAP similar genes for TCL1A using alignment to 3 protein entries:     TCL1A_HUMAN (see all proteins):
    MTCP1    TCL1B

    Find genes that share paralogs with TCL1A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCL1A (see all 127)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433544001,2
    C--96175810(+) GAAGG-/CATC  
            
    CATCC
    3 -- int10--------
    rs2014536231,2
    --96175813(+) GGCAT-/CCAG  
            
    CCCCT
    3 -- int10--------
    rs1997221231,2
    C--96175815(+) CATCC-/AT    
       
    /ATCC
    CCTGG
    3 -- int10--------
    rs118495381,2
    C,F,H--96175978(+) AGGGAC/GAGCTT 3 -- int116Minor allele frequency- G:0.23NA NS EA WA CSA 1075
    rs740878181,2
    C,F--96175984(+) AGCTTC/TAGGCA 3 -- int12Minor allele frequency- T:0.21WA 120
    rs1448642211,2
    --96176067(+) CCCAGA/GTAAGG 3 -- int10--------
    rs1151936061,2
    C,F--96176105(+) GCACAT/CGGGAA 3 -- int11Minor allele frequency- C:0.03WA 118
    rs170932851,2
    C,F,H--96176204(+) CTCCAA/GTGGTT 3 -- int115Minor allele frequency- G:0.06NA EA NS WA 1412
    rs1481640201,2
    C--96176206(+) CCAATA/GGTTCT 3 -- int10--------
    rs1419643061,2
    --96176216(+) TCAACA/GTATGC 3 -- int10--------

    HapMap Linkage Disequilibrium report for TCL1A (96176304 - 96180533 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TCL1A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCL1A
    DNA2.0 Custom Variant and Variant Library Synthesis for TCL1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186960    OMIM disorders: --

    UniProtKB/Swiss-Prot: TCL1A_HUMAN, P56279
  • Note=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL).
    Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the
    T-cell receptor alpha/delta loci

  • 14 diseases for TCL1A:    
    About MalaCards
    urocanase deficiency    leukemia/lymphoma, t-cell    mature b-cell neoplasm    t-cell leukemia
    pre-b-cell acute lymphoblastic leukemia    malignant germ cell tumor    t-cell prolymphocytic leukemia    precursor t-cell acute lymphoblastic leukemia
    b-cell lymphomas    blastic plasmacytoid dendritic cell    burkitt's lymphoma    chronic lymphocytic leukemia
    b-cell chronic lymphocytic leukemia    leukemia

    3 diseases from the University of Copenhagen DISEASES database for TCL1A:
    Leukemia     Lymphoma     Ataxia telangiectasia

    Find genes that share disorders with TCL1A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TCL1A gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia prolymphocytic 93.1 14 9691281 (1), 8634440 (1), 9657733 (1), 10959629 (1) (see all 12)
    leukemia t-cell 89.6 45 11607815 (4), 11710897 (2), 12011454 (2), 10077617 (2) (see all 30)
    lymphocytic leukemia t-cell chronic 80.5 3 9520462 (1), 10197596 (1)
    ataxia telangiectasia 69.6 7 8634440 (1), 11752899 (1), 11297767 (1), 7662982 (1) (see all 6)
    leukemia lymphocytic chronic 65.1 9 16341048 (2), 17178851 (1), 12011454 (1), 15661260 (1) (see all 7)
    lymphoma b-cell 62.1 14 16978196 (3), 19966860 (2), 10786666 (2), 20079013 (2) (see all 8)
    lymphoma 62 44 11304575 (7), 10792782 (6), 19147787 (3), 16978196 (2) (see all 16)
    leukemogenesis 59.7 4 10851082 (1), 10344735 (1), 11707444 (1), 17846228 (1)
    leukemia 59.5 14 9520462 (2), 12011454 (1), 12576313 (1), 11054065 (1) (see all 12)
    burkitt lymphoma 57.3 9 20079013 (3), 16146820 (2), 11241786 (1), 11707444 (1) (see all 5)

    Genatlas disease: TCL1A
    chronic lymphocytic leukemia (T-CLL) associated breakpoint 1,with inversion inv(14) (q11;q32) and translocations
    t(14;14)(q11;q32),t(7;14)(q35;q32)

    Genetic Association Database (GAD): TCL1A
    Human Genome Epidemiology (HuGE) Navigator: TCL1A (3 documents)

    Export disorders for TCL1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCL1A gene, integrated from 10 sources (see all 138):
    (articles sorted by number of sources associating them with TCL1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the TCL1 gene involved in T-cell malignancies. (PubMed id 7809072)1, 2, 3, 9 Virgilio L.... Russo G. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. The protooncogene TCL1 is an Akt kinase coactivator. (PubMed id 10983986)1, 2, 9 Laine J.... Noguchi M. (Mol. Cell 2000)
    3. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PubMed id 11707444)1, 2, 9 Laine J.... Noguchi M. (J. Biol. Chem. 2002)
    4. Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology. (PubMed id 9519406)1, 2, 9 Hoh F.... van Tilbourgh H. (Structure 1998)
    5. Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors. (PubMed id 20876420)1, 4 Ingle J.N....Weinshilboum R.M. (J. Clin. Oncol. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Genome-wide case-control study of musculoskeletal adverse events and functional genomics in women receiving aromatase inhibitors: going beyond associations. (PubMed id 21172079)1, 4 Ingle J.N. (Breast Cancer Res. 2010)
    8. The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity. (PubMed id 16934922)1, 2 French S.W....Teitell M.A. (Cancer Lett. 2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Characterization and localization of the TCL-1 oncogene product. (PubMed id 7987816)1, 2 Fu T.-B....Croce C.M. (Cancer Res. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8115 HGNC: 11648 AceView: TCL1A Ensembl:ENSG00000100721 euGenes: HUgn8115
    ECgene: TCL1A Kegg: 8115 H-InvDB: TCL1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCL1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TCL1A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TCL1A gene:
    Search GeneIP for patents involving TCL1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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