TCL1A Gene

Aliases
for TCL1A gene

Previous GC identifers: GC14M093687 GC14M089992 GC14M094166 GC14M095246 GC14M076361

Summaries
for TCL1A gene

Genomic Views
for TCL1A gene

RefSeq DNA sequence:

NC_000014.8  NC_018925.1  NT_026437.12  

SwitchGear Promoter luciferase reporter plasmid: TCL1A promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCL1A

TCL1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M096177:  view genomic region     (about GC identifiers)

Proteins
for TCL1A gene

1 PDB 3D structure from and Proteopedia for TCL1A:

1JSG (3D)    

Explore the universe of human proteins at neXtProt for TCL1A: NX_P56279

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): TCL1A OriGene Protein Over-expression Lysate (see all 3): TCL1A OriGene Custom Protein Services for TCL1A
	GenScript Custom Purified and Recombinant Proteins Services for TCL1A
	Novus Biologicals TCL1A Proteins Novus Biologicals TCL1A Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for TCL1A
	Uscn Proteins for TCL1A

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TCL1A
	R&D Systems Antibodies for TCL1A
	Cell Signaling Technology (CST) Antibodies for TCL1A
	OriGene Antibodies (see all 2): TCL1A OriGene Custom Antibody Services for TCL1A
	GenScript Custom Superior Antibodies Services for TCL1A
	Novus Biologicals TCL1A Antibodies
	Abcam antibodies for TCL1A
	Uscn Antibodies for TCL1A
	ThermoFisher Antibodies for TCL1A

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TCL1A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TCL1A

Protein Domains /
Families
for TCL1A gene

ProtoNet protein and cluster: P56279

Function
for TCL1A gene

miRNA Products:		miRTarBase miRNAs that target TCL1A: hsa-mir-29b (MIRT004510), hsa-mir-181b (MIRT005106)
		OriGene 3'-UTR Clone (see all 2): TCL1A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCL1A
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate TCL1A:
		hsa-miR-3176 hsa-miR-3922-3p hsa-miR-3126-5p
		SwitchGear 3'UTR luciferase reporter plasmid: TCL1A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCL1A (see all 4) OriGene shRNA RFP: TCL1A OriGene siRNA: TCL1A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCL1A

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TCL1A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCL1A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCL1A (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TCL1A (NM_021966)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCL1A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCL1A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TCL1A
		Search LifeMap BioReagents cell lines for TCL1A

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCL1A

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Tcl1)

Pathways & Interactions
for TCL1A gene

	Super-pathway	contained gene-specific pathways
1	Selected targets of Oct-3/4	Selected targets of Oct-3/4 1.00
2	PI3K / Akt Signaling	PI3K / Akt Signaling 1.00

1 EMD Millipore Pathway for TCL1A

Selected targets of Oct-3/4

1 Cell Signaling Technology (CST) Pathway for TCL1A

PI3K / Akt Signaling

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for TCL1A gene

Transcripts
for TCL1A gene

Expression
for TCL1A gene

TCL1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATACTTTTT

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	OvaryAntral FollicleSecondary Oocyte			Female Gametocytes, Germ Cells
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 4 LifeMap Cells
	Name			Category
	Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	Secondary follicles (Primary Cell)			Ovary, Reproductive System
	Epiblast-like cells (Reconstitution of mo...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCL1A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TCL1A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCL1A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCL1A

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCL1A

Orthologs
for TCL1A gene

Paralogs
for TCL1A gene

Paralogs for TCL1A gene

MTCP1²  TCL1B²  

2 SIMAP similar genes for TCL1A using alignment to 3 protein entries:     TCL1A_HUMAN (see all proteins):

MTCP1    TCL1B

TCL1A for paralogs           About GeneDecksing

Genomic Variants
for TCL1A gene

10/190 NCBI SNPs in TCL1A are shown (see all 190)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs756750561,2		--	76365551(+)	AGAGAT/AACCCA	1	--	us2k1		1		WA	118
rs733501461,2	C,	--	76366392(+)	GAAGAC/ACCCCC	1	--	us2k1		1		WA	2
rs19579361,2	H	--	76366520(+)	CGGGCC/TTGAGT	1	--	us2k1		4		NS EA	420
rs754026401,2	F,	--	76366718(+)	TTTTTG/CCCCTT	1	--	us2k1		1		WA	118
rs769479751,2	C,F,	--	76366853(+)	TAAATT/CACAAG	1	--	us2k1		1		WA	118
rs1122255111,2		--	76367506(+)	TGTGGC/GCAGGG	1	--	nc-transcript-variant		2		CSA WA	120
rs1160152091,2	C,F,	--	76367616(+)	GTCTGG/AGTAAG	1	--	nc-transcript-variant		1		WA	118
rs769247941,2	F,	--	76367794(+)	GATGTC/GTGTGG	1	--	int1		1		WA	118
rs19519891,2	H,	--	76367846(+)	TGAACA/GTTCCA	1	--	int1		4		NS EA	420
rs1433544001,2	C,	--	96175810(+)	GAAGG-/CATC           CATCC	3	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for TCL1A (96176304 - 96180533 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for TCL1A: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCL1A

DNA2.0 Custom Variant and Variant Library Synthesis for TCL1A

Disorders / Diseases
for TCL1A gene

20/32 diseases for TCL1A

10/27 Novoseek disease relationships for TCL1A gene (see all 27)    About this table

Publications
for TCL1A gene

PubMed articles for TCL1A gene, integrated from 9 sources (see all 131): (articles sorted by number of sources associating them with TCL1A)

Utopia: connect your pdf to the dynamic world of online information

1. Identification of the TCL1 gene involved in T-cell malignancies. (PubMed id 7809072)^{1, 2, 3, 9} Virgilio L....Russo G. (1994)
2. The protooncogene TCL1 is an Akt kinase coactivator. (PubMed id 10983986)^{1, 2, 9} Laine J....Noguchi M. (2000)
3. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PubMed id 11707444)^{1, 2, 9} Laine J.... Noguchi M. (2002)
4. Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology. (PubMed id 9519406)^{1, 2, 9} Hoh F.... van Tilbourgh H. (1998)
5. The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity. (PubMed id 16934922)^{1, 2} French S.W....Teitell M.A. (2007)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. Characterization and localization of the TCL-1 oncogene product. (PubMed id 7987816)^{1, 2} Fu T.-B....Croce C.M. (1994)
8. Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient. (PubMed id 2783489)^{1, 3} Russo G....Croce C.M. (1989)
9. Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. (PubMed id 10716693)^{2, 9} Pekarsky Y.... Croce C.M. (2000)
10. Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia. (PubMed id 9738977)^{1, 9} Takizawa J....Seto M. (1998)

External Searches for TCL1A gene

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Products
for TCL1A gene