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Aliases for TCHP Gene

Aliases for TCHP Gene

  • Trichoplein, Keratin Filament Binding 2 3
  • Mitostatin 2 3 4
  • Mitochondrial Protein With Oncostatic Activity 3 4
  • Tumor Suppressor Protein 3 4
  • Trichoplein Keratin Filament-Binding Protein 3
  • Protein TCHP 4
  • TpMs 3

External Ids for TCHP Gene

Summaries for TCHP Gene

GeneCards Summary for TCHP Gene

TCHP (Trichoplein, Keratin Filament Binding) is a Protein Coding gene. Among its related pathways are Cytoskeleton remodeling Neurofilaments.

UniProtKB/Swiss-Prot for TCHP Gene

  • Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a capping or branching protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.

Gene Wiki entry for TCHP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCHP Gene

Genomics for TCHP Gene

Genomic Location for TCHP Gene

Start:
109,900,264 bp from pter
End:
109,983,841 bp from pter
Size:
83,578 bases
Orientation:
Plus strand

Genomic View for TCHP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCHP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCHP Gene

Regulatory Elements for TCHP Gene

Proteins for TCHP Gene

  • Protein details for TCHP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT92-TCHP_HUMAN
    Recommended name:
    Trichoplein keratin filament-binding protein
    Protein Accession:
    Q9BT92
    Secondary Accessions:
    • Q8NAG0

    Protein attributes for TCHP Gene

    Size:
    498 amino acids
    Molecular mass:
    61072 Da
    Quaternary structure:
    • Interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 and KRT18.

neXtProt entry for TCHP Gene

Proteomics data for TCHP Gene at MOPED

Post-translational modifications for TCHP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCHP Gene

No data available for DME Specific Peptides for TCHP Gene

Domains for TCHP Gene

Protein Domains for TCHP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCHP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BT92

UniProtKB/Swiss-Prot:

TCHP_HUMAN
Family:
  • Belongs to the TCHP family.:
    • Q9BT92
genes like me logo Genes that share domains with TCHP: view

No data available for Gene Families for TCHP Gene

Function for TCHP Gene

Molecular function for TCHP Gene

UniProtKB/Swiss-Prot Function: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a capping or branching protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.

Gene Ontology (GO) - Molecular Function for TCHP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15731013
genes like me logo Genes that share ontologies with TCHP: view

Phenotypes for TCHP Gene

GenomeRNAi human phenotypes for TCHP:
genes like me logo Genes that share phenotypes with TCHP: view

miRNA for TCHP Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TCHP Gene

Localization for TCHP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCHP Gene

Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCHP Gene COMPARTMENTS Subcellular localization image for TCHP gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
plasma membrane 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for TCHP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA 18931701
GO:0005813 centrosome IDA --
GO:0005886 plasma membrane IDA --
GO:0045095 keratin filament IDA 15731013
genes like me logo Genes that share ontologies with TCHP: view

Pathways for TCHP Gene

genes like me logo Genes that share pathways with TCHP: view

Pathways by source for TCHP Gene

1 GeneGo (Thomson Reuters) pathway for TCHP Gene

Gene Ontology (GO) - Biological Process for TCHP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IDA 18931701
GO:0030308 negative regulation of cell growth IDA 18931701
genes like me logo Genes that share ontologies with TCHP: view

Transcripts for TCHP Gene

Unigene Clusters for TCHP Gene

Trichoplein, keratin filament binding:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCHP Gene

No ASD Table

Relevant External Links for TCHP Gene

GeneLoc Exon Structure for
TCHP
ECgene alternative splicing isoforms for
TCHP

Expression for TCHP Gene

mRNA expression in normal human tissues for TCHP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCHP Gene

SOURCE GeneReport for Unigene cluster for TCHP Gene Hs.410924

mRNA Expression by UniProt/SwissProt for TCHP Gene

Q9BT92-TCHP_HUMAN
Tissue specificity: Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis.
genes like me logo Genes that share expressions with TCHP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TCHP Gene

Orthologs for TCHP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCHP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCHP 35
  • 98.72 (n)
  • 98.58 (a)
TCHP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCHP 35
  • 85.88 (n)
  • 84.54 (a)
TCHP 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCHP 35
  • 86.68 (n)
  • 86.14 (a)
TCHP 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tchp 35
  • 80.95 (n)
  • 77.46 (a)
Tchp 16
Tchp 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCHP 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCHP 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tchp 35
  • 79.95 (n)
  • 75.65 (a)
chicken
(Gallus gallus)
Aves TCHP 35
  • 63.66 (n)
  • 60.66 (a)
TCHP 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tchp 35
  • 61.91 (n)
  • 59.04 (a)
zebrafish
(Danio rerio)
Actinopterygii tchp 35
  • 60.91 (n)
  • 56.22 (a)
tchp 36
  • 55 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for TCHP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCHP Gene

ENSEMBL:
Gene Tree for TCHP (if available)
TreeFam:
Gene Tree for TCHP (if available)

Paralogs for TCHP Gene

No data available for Paralogs for TCHP Gene

Variants for TCHP Gene

Sequence variations from dbSNP and Humsavar for TCHP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs871789 -- 109,913,422(+) TAAAC(A/G)GCATG intron-variant
rs1045802 -- 109,916,831(+) CTTAC(A/C)CAAGC utr-variant-3-prime, downstream-variant-500B
rs1124396 -- 109,909,333(+) AAAAA(A/G)CAGCA intron-variant
rs1567471 -- 109,908,982(-) TTTTT(A/T)CAAAA intron-variant
rs2271317 -- 109,907,427(-) GGCAG(A/T)TCCTG intron-variant

Relevant External Links for TCHP Gene

HapMap Linkage Disequilibrium report
TCHP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCHP Gene

Disorders for TCHP Gene

No disorders were found for TCHP Gene.

No data available for UniProtKB/Swiss-Prot for TCHP Gene

Publications for TCHP Gene

  1. Identification of trichoplein, a novel keratin filament-binding protein. (PMID: 15731013) Nishizawa M. … Inagaki M. (J. Cell Sci. 2005) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer. (PMID: 18931701) Vecchione A. … Baffa R. (Oncogene 2009) 3 4
  4. Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition. (PMID: 20930847) Cerqua C. … Scorrano L. (EMBO Rep. 2010) 2 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for TCHP Gene

Sources for TCHP Gene

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