TCHP Gene
protein-coding GIFtS: 50
GCID: GC12P110338
|
|
trichoplein, keratin filament binding
| |
Aliases
for TCHP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Trichoplein, Keratin Filament Binding1 2 | | Mitostatin3 | | TpMs1 2 | | Trichoplein Keratin Filament-Binding Protein2 | | Mitochondrial Protein With Oncostatic Activity2 3 | | Mitostatin3 | | Tumor Suppressor Protein2 3 | | Protein TCHP3 | | MGC108541 | | |
Export aliases for TCHP gene to outside databasesPrevious GC identifers: GC12P108802 GC12P107354 |
Summaries
for TCHP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TCHP_HUMAN, Q9BT92Function: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress.Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting itsphosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. Mayregulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelialcells
Gene Wiki entry for TCHP
|
Genomic Views
for TCHP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TCHP gene promoter:
RFX1 STAT5A LUN-1 Pax-4a GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCHP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCHP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.11 Ensembl cytogenetic band: 12q24.11 HGNC cytogenetic band: 12q24.11TCHP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P110338: view genomic region
(about GC identifiers)
Start:
|
110,338,069 bp from pter |
End:
|
110,421,646 bp from pter |
Size:
|
83,578 bases |
Orientation:
|
plus strand |
|
Proteins
for TCHP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TCHP_HUMAN, Q9BT92 (See
protein sequence)Recommended Name: Trichoplein keratin filament-binding protein Size: 498 amino acids; 61072 Da
Subunit: Interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 and KRT18
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion
Secondary accessions: Q8NAG0Explore the universe of human proteins at neXtProt for TCHP: NX_Q9BT92
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BT92
TCHP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001137324.1 NP_115676.1
ENSEMBL proteins: ENSP00000440838 ENSP00000384520 ENSP00000324404 ENSP00000441835 ENSP00000447183
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
TCHP for ontologies About GeneDecksing
TCHP Antibody Products:
Assay Products for TCHP: |
Protein
Domains /
Families
for TCHP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCHP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BT92ProtoNet protein and cluster: Q9BT92 UniProtKB/Swiss-Prot: TCHP_HUMAN, Q9BT92Similarity: Belongs to the TCHP family |
Function
for TCHP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TCHP_HUMAN, Q9BT92Function: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress.Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting itsphosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. Mayregulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelialcells
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCHP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCHP (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TCHP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCHP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCHP |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
TCHP for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TCHP:
|
Pathways & Interactions
for TCHP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytoskeleton remodeling Keratin filaments | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TCHP
1  GeneGo (Thomson Reuters) Pathway for TCHP
TCHP for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCHP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/13 Interacting proteins for TCHP (Q9BT922, 3 ENSP000003244044) via UniProtKB, MINT, STRING, and/or I2D (see all 13)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CCDC85B | Q158342, 3, ENSP000003116954 | MINT-67296 I2D:
score=5 STRING: ENSP00000311695 | | KRT15 | P190122, 3, ENSP000002540434 | MINT-66456 I2D:
score=5 STRING: ENSP00000254043 | | NME7 | Q9Y5B82, 3, ENSP000003567854 | MINT-67218 I2D:
score=5 STRING: ENSP00000356785 | | TEX11 | Q8IYF32, 3, ENSP000003409954 | MINT-67777 I2D:
score=5 STRING: ENSP00000340995 | | VIM | P086702, 3, ENSP000002242374 | MINT-66106 I2D:
score=5 STRING: ENSP00000224237 |
About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
TCHP for ontologies About GeneDecksing
|
Drugs & Compounds
for TCHP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TCHP
Search CenterWatch for drugs/clinical trials and news about TCHP
|
Transcripts
for TCHP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCHP gene (2 alternative transcripts): NM_001143852.1 NM_032300.4 Unigene Cluster for TCHP: Trichoplein, keratin filament binding Hs.410924 [show with all ESTs]Unigene Representative Sequence: NM_03230010 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000537218 ENST00000544838(uc001tpo.1) ENST00000405876(uc001tpn.3)
ENST00000312777(uc001tpp.3) ENST00000536408 ENST00000549550 ENST00000551627
ENST00000537880 ENST00000549524 ENST00000550780
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCHP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCHP (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TCHP (NM_032300) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCHP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCHP |
Additional cDNA sequence: AK000079.1 AK301262.1 AY007230.1 AY210413.1 BC004285.1 BC022838.1 BX648596.1 7 DOTS entries: DT.406404 DT.100749675 DT.121146483 DT.91822531 DT.95187472 DT.91691330 DT.411965 24/98 AceView cDNA sequences (see all 98): BX097816 BM541692 BX648596 BQ632075 BC022838 CK902166 BC004285 BU622721 BG681703 BU163267 AY007230 AA736767 NM_032300 AW672786 AK092736 BQ631775 AW136783 AI589290 AX747696 AK000079 AI791723 AI822006 CK902165 AI733413
GeneLoc Exon Structure
|
Expression
for TCHP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCHP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTCTGTTG
About this image
See TCHP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCHP
SOURCE GeneReport for Unigene cluster: Hs.410924
UniProtKB/Swiss-Prot: TCHP_HUMAN, Q9BT92Tissue specificity: Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in thesmooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at proteinlevel). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis
SABiosciences Custom PCR Arrays for TCHP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCHP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TCHP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCHP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCHP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCHP |
Orthologs
for TCHP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TCHP gene from 4/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC4252091 |
trichoplein keratin filament-binding protein-like |
63.81(n)
60.66(a) |
|
425209 XM_422992.3 XP_422992.3 |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC042932.12 |
-- |
72.09(n) |
|
BC042932.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
tchp1 |
trichoplein, keratin filament binding |
60.97(n)
56.34(a) |
|
678595 NM_001040343.1 NP_001035433.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG114496 |
-- |
10(a) |
1 → many |
3L(22447473-22449089) |
ENSEMBL Gene Tree for TCHP (if available)
TreeFam Gene Tree for TCHP (if available) |
Paralogs
for TCHP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TCHP gene
- CCDC112 MNS12 CCDC1732 CCDC192
TCHP for paralogs About GeneDecksing
|
Genomic Variants
for TCHP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TCHP (110338069 - 110421646 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TCHP: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCHP |
|
Disorders
/ Diseases
for TCHP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCHP for disorders About GeneDecksing
OMIM gene information: 612654
OMIM disorders: --
10  diseases for TCHP: About MalaCardsintermittent claudication velocardiofacial syndrome digeorge syndrome thyroid cancer
breast carcinoma thyroiditis prostate cancer breast cancer
prostatitis carcinoma
Export disorders for TCHP gene to outside databases
|
Publications
for TCHP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCHP gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with TCHP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of trichoplein, a novel keratin filament-binding protein. (PubMed id 15731013)1, 2, 3, 9 Nishizawa M.... Inagaki M. (2005)
- Trichoplein/mitostatin regulates endoplasmic reticulu m-mitochondria juxtaposition. (PubMed id 20930847)1, 3 Cerqua C....Scorrano L. (2010)
- MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer. (PubMed id 18931701)1, 2 Vecchione A....Baffa R. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Trichoplein controls microtubule anchoring at the cen trosome by binding to Odf2 and ninein. (PubMed id 21325031)1 Ibi M....Inagaki M. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Small urine leak after renal transplantation: detection by delayed 99mTc-DTPA renography--a case report. (PubMed id 15731018)1 Yu J.Q....Alavi A. (2005)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Outpatient therapeutic 131I for thyroid cancer. (PubMed id 15731017)1 Panzegrau B....Goudy G.H. (2005)
|
External Searches for TCHP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TCHP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCHP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCHP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TCHP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TCHP gene:
Search GeneIP for patents involving TCHP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCHP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCHP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCHP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCHP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCHP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCHP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCHP |
| |
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| |  |  |  |  | | | | |
 |
 |
 |
 | | | TCHP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCHP |
|  |  |  | | | | ThermoFisher Antibody for TCHP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCHP |
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