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TCHP Gene

protein-coding   GIFtS: 52
GCID: GC12P110338

Trichoplein, Keratin Filament Binding

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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Trichoplein, Keratin Filament Binding1 2     TpMs2
mitostatin1 2     Trichoplein Keratin Filament-Binding Protein2
Mitochondrial Protein With Oncostatic Activity2 3     Mitostatin3
Tumor Suppressor Protein2 3     Protein TCHP3

External Ids:    HGNC: 281351   Entrez Gene: 842602   Ensembl: ENSG000001394377   OMIM: 6126545   UniProtKB: Q9BT923   
ORGUL members:         

Export aliases for TCHP gene to outside databases

Previous GC identifers: GC12P108802 GC12P107354


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TCHP Gene:
TCHP (trichoplein, keratin filament binding) is a protein-coding gene.

UniProtKB/Swiss-Prot: TCHP_HUMAN, Q9BT92
Function: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress.
Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its
phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May
regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple
epithelial cells

Gene Wiki entry for TCHP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCHP gene promoter:
         RFX1   STAT5A   LUN-1   Pax-4a   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCHP promoter sequence
   Search Chromatin IP Primers for TCHP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCHP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.11

TCHP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCHP gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P110338:  view genomic region     (about GC identifiers)

Start:
110,338,069 bp from pter      End:
110,421,646 bp from pter
Size:
83,578 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCHP_HUMAN, Q9BT92 (See protein sequence)
Recommended Name: Trichoplein keratin filament-binding protein  
Size: 498 amino acids; 61072 Da
Subunit: Interacts specifically with keratin proteins including, KRT5, KRT6A, KRT8, KRT14, KRT16 and KRT18
Secondary accessions: Q8NAG0

Explore the universe of human proteins at neXtProt for TCHP: NX_Q9BT92

Explore proteomics data for TCHP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TCHP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137324.1  NP_115676.1  

    ENSEMBL proteins: 
     ENSP00000440838   ENSP00000384520   ENSP00000324404   ENSP00000441835  

    TCHP Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TCHP

     
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    Search eBioscience for ELISAs for TCHP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026773 TCHP/CCDC11

    Graphical View of Domain Structure for InterPro Entry Q9BT92

    ProtoNet protein and cluster: Q9BT92

    UniProtKB/Swiss-Prot: TCHP_HUMAN, Q9BT92
    Similarity: Belongs to the TCHP family


    Find genes that share domains with TCHP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCHP_HUMAN, Q9BT92
    Function: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress.
    Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its
    phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May
    regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple
    epithelial cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15731013
         
    Find genes that share ontologies with TCHP           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TCHP:
     Increased S DNA content, incre  Small cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCHP
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TCHP

    miRNA
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    miRTarBase miRNAs that target TCHP:
    hsa-mir-92a-3p (MIRT049541), hsa-mir-215-5p (MIRT024401), hsa-mir-484 (MIRT042371), hsa-mir-192-5p (MIRT026122)

    Block miRNA regulation of human, mouse, rat TCHP using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate TCHP:
    hsa-miR-1290 hsa-miR-612 hsa-miR-3122 hsa-miR-330-5p hsa-miR-3913-5p hsa-miR-326 hsa-miR-3674 hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidTCHP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCHP_HUMAN, Q9BT92: Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    mitochondrion5
    plasma membrane5
    cytosol3
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA18931701
    GO:0005739mitochondrion IDA18931701
    GO:0005813centrosome IDA--
    GO:0005886plasma membrane IDA18931701
    GO:0045095keratin filament IDA15731013

    Find genes that share ontologies with TCHP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TCHP About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoskeleton remodeling Keratin filaments
    Cytoskeleton remodeling Keratin filaments

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for TCHP
        Cytoskeleton remodeling Keratin filaments



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCHP
    Interactions:

        Search GeneGlobe Interaction Network for TCHP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TCHP (Q9BT922, 3 ENSP000003244044) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-67296 I2D: score=5 STRING: ENSP00000311695
    KRT15P190122, 3, ENSP000002540434MINT-66456 I2D: score=5 STRING: ENSP00000254043
    NME7Q9Y5B82, 3, ENSP000003567854MINT-67218 I2D: score=5 STRING: ENSP00000356785
    TEX11Q8IYF32, 3, ENSP000003409954MINT-67777 I2D: score=5 STRING: ENSP00000340995
    VIMP086702, 3, ENSP000002242374MINT-66106 I2D: score=5 STRING: ENSP00000224237
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IDA18931701
    GO:0030308negative regulation of cell growth IDA18931701

    Find genes that share ontologies with TCHP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCHP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TCHP gene (2 alternative transcripts): 
    NM_001143852.1  NM_032300.4  

    Unigene Cluster for TCHP:

    Trichoplein, keratin filament binding
    Hs.410924  [show with all ESTs]
    Unigene Representative Sequence: NM_032300
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537218 ENST00000544838(uc001tpo.1) ENST00000405876(uc001tpn.3)
    ENST00000312777(uc001tpp.3) ENST00000536408 ENST00000549550 ENST00000551627
    ENST00000537880 ENST00000549524 ENST00000550780
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate TCHP:
    hsa-miR-1290 hsa-miR-612 hsa-miR-3122 hsa-miR-330-5p hsa-miR-3913-5p hsa-miR-326 hsa-miR-3674 hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidTCHP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TCHP
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TCHP (NM_032300)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCHP
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat TCHP

    Additional mRNA sequence: 

    AK000079.1 AK301262.1 AY007230.1 AY210413.1 BC004285.1 BC022838.1 BX648596.1 

    7 DOTS entries:

    DT.406404  DT.100749675  DT.121146483  DT.91822531  DT.95187472  DT.91691330  DT.411965 

    Selected AceView cDNA sequences (see all 98):

    AI791723 BG681703 BQ632075 AW136783 BU163267 BX097816 BM541692 BX648596 
    AA923604 BE465774 AI733413 AI822006 AK000079 AX747696 BC004285 NM_032300 
    BU622721 CK902166 AA736767 BQ631775 AW672786 AK092736 AI589290 CK902165 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCHP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTCTGTTG
    TCHP Expression
    About this image

    TCHP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCHP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.410924

    UniProtKB/Swiss-Prot: TCHP_HUMAN, Q9BT92
    Tissue specificity: Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in
    the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at
    protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TCHP gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tchp1 , 5 trichoplein, keratin filament binding1, 5 80.95(n)1
    77.46(a)1
      5 (55.99 cM)5
    778321  NM_029992.21  NP_084268.21 
     1147077605 
    chicken
    (Gallus gallus)
    Aves TCHP1 trichoplein, keratin filament binding 63.66(n)
    60.66(a)
      425209  XM_422992.4  XP_422992.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia BC042932.12   -- 72.09(n)    BC042932.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tchp1 trichoplein, keratin filament binding 60.91(n)
    56.22(a)
      678595  NM_001040343.1  NP_001035433.1 


    ENSEMBL Gene Tree for TCHP (if available)
    TreeFam Gene Tree for TCHP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCHP (see all 518)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0640564
    A gastric carcinoma sample4--see VAR_0640562 S P mis40--------
    VAR_0640574
    A pancreatic carcinoma sample4--see VAR_0640572 E K mis40--------
    rs1435299781,2
    --110336109(+) TCCTCA/GGTTGA 1 -- us2k10--------
    rs1923610521,2
    --110336146(+) AGTAGC/GTGGGA 1 -- us2k10--------
    rs1844600471,2
    --110336172(+) ACCACA/GCCCAG 1 -- us2k10--------
    rs110688241,2
    C--110336245(+) CCTGAC/TCTCAA 1 -- us2k16Minor allele frequency- T:0.20WA CSA NA EA 363
    rs1134546901,2
    C,F--110336258(+) GATCCG/ACCAGC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs789425841,2
    --110336343(+) TCATTA/CCATGG 2 -- us2k10--------
    rs1492516311,2
    --110336351(+) TGGACC/TAGGAA 2 -- us2k10--------
    rs1444262261,2
    C--110336372(+) AGACAA/GATGAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TCHP (110338069 - 110421646 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TCHP: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCHP
    DNA2.0 Custom Variant and Variant Library Synthesis for TCHP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612654    OMIM disorders: --


    Find genes that share disorders with TCHP           About GenesLikeMe


    Export disorders for TCHP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCHP gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with TCHP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of trichoplein, a novel keratin filament-binding protein. (PubMed id 15731013)1, 2, 3, 9 Nishizawa M.... Inagaki M. (J. Cell Sci. 2005)
    2. Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition. (PubMed id 20930847)1, 3 Cerqua C....Scorrano L. (EMBO Rep. 2010)
    3. MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer. (PubMed id 18931701)1, 2 Vecchione A.... Baffa R. (Oncogene 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    6. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PubMed id 23319000)1 Luykx J.J....Ophoff R.A. (Mol. Psychiatry 2013)
    7. Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. (PubMed id 21325031)1 Ibi M....Inagaki M. (J. Cell. Sci. 2011)
    8. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84260 HGNC: 28135 AceView: MGC10854 Ensembl:ENSG00000139437 euGenes: HUgn84260
    ECgene: TCHP H-InvDB: TCHP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCHP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCHP gene:
    Search GeneIP for patents involving TCHP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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