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TCHH Gene

protein-coding   GIFtS: 47
GCID: GC01M152078

Trichohyalin


(Previous symbol: THH)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
trichohyalin1 2
THH1 2 3 5
THL2 3 5
TRHY2 3 5

External Ids:    HGNC: 117911   Entrez Gene: 70622   Ensembl: ENSG000001594507   OMIM: 1903705   UniProtKB: Q072833   

Export aliases for TCHH gene to outside databases

Previous GC identifers: GC01U901218 GC01M150345 GC01M123456


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCHH Gene:
Trichohyalin confers mechanical strength to the hair follicle inner root sheath and to other toughened epithelial
tissues, such as the hard palate and filiform ridges of the tongue, by forming multiple complex crosslinks with
itself and with other structural proteins (Steinert et al., 2003 (PubMed 12853460)).(supplied by OMIM, Dec 2009)

GeneCards Summary for TCHH Gene:
TCHH (trichohyalin) is a protein-coding gene. Diseases associated with TCHH include brown-sequard syndrome, and tabes dorsalis. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is RPTN.

UniProtKB/Swiss-Prot: TRHY_HUMAN, Q07283
Function: Intermediate filament-associated protein that associates in regular arrays with keratin intermediate
filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It
later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with
involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may
be involved in its own calcium-dependent postsynthetic processing during terminal differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCHH gene promoter:
         SRF   SRF (504 AA)   NCX/Ncx   STAT5A   Nkx2-5   C/EBPalpha   HFH-1   Chx10   LyF-1   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TCHH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCHH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21-q23

TCHH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCHH gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M152078:  view genomic region     (about GC identifiers)

Start:
152,078,793 bp from pter      End:
152,086,556 bp from pter
Size:
7,764 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRHY_HUMAN, Q07283 (See protein sequence)
Recommended Name: Trichohyalin  
Size: 1943 amino acids; 253925 Da
Subunit: Monomer (Probable)
Developmental stage: Expressed during late differentiation of the epidermis
Sequence caution: Sequence=AAA65582.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5VUI3

Explore the universe of human proteins at neXtProt for TCHH: NX_Q07283

Explore proteomics data for TCHH at MOPED

Post-translational modifications: 

  • Substrate of transglutaminase. Some 200 arginines are probably converted to citrullines by peptidylarginine
    deimidase1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TCHH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009044.2  
    ENSEMBL proteins: 
     ENSP00000357794  

    TCHH Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for TCHH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    5 InterPro protein domains:
     IPR018247 EF_Hand_1_Ca_BS
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR013787 S100_Ca-bd_sub
     IPR001751 S100/CaBP-9k_CS

    Graphical View of Domain Structure for InterPro Entry Q07283

    ProtoNet protein and cluster: Q07283

    1 Blocks protein domain: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: TRHY_HUMAN, Q07283
    Domain: Consists of nine domains. Domain 1 contains two EF-hand calcium-binding domains. Domains 2-4, 6, and 8 are
    almost entirely alpha-helical, configured as a series of peptide repeats of varying regularity, and are thought
    to form a single-stranded alpha-helical rod stabilized by ionic interactions. Domain 6 is the most regular and
    may bind KIF directly by ionic interactions. Domains 5 and 7 are less well organized and may induce folds in the
    molecule. Domain 9 contains the C-terminus, conserved among different species
    Similarity: Belongs to the S100-fused protein family
    Similarity: Contains 2 EF-hand domains


    TCHH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRHY_HUMAN, Q07283
    Function: Intermediate filament-associated protein that associates in regular arrays with keratin intermediate
    filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It
    later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with
    involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may
    be involved in its own calcium-dependent postsynthetic processing during terminal differentiation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding TAS7685034
         
    TCHH for ontologies           About GeneDecksing


    Animal Models:
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    hsa-miR-4265 hsa-miR-3065-5p hsa-miR-944 hsa-miR-3133 hsa-miR-1305 hsa-miR-211 hsa-miR-188-3p hsa-miR-204
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    plasma membrane4
    cytosol3
    endoplasmic reticulum1
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005813centrosome ----
    GO:0005856cytoskeleton NAS7686953
    GO:0005886plasma membrane ----
    GO:0045111intermediate filament cytoskeleton ----

    TCHH for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCHH
    Interactions:

        Search GeneGlobe Interaction Network for TCHH

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TCHH (Q072833 ENSP000003577944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFHD1Q9BUP03, ENSP000002640594I2D: score=1 STRING: ENSP00000264059
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0031424keratinization IEA--

    TCHH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCHH (TRHY)

    1 HMDB Compound for TCHH    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 Novoseek inferred chemical compound relationships for TCHH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    citrulline 54.6 1 16086740 (1)
    arginine 18 3 11069618 (1), 16086740 (1)
    calcium 0 2 8618063 (1), 9274619 (1)



    TCHH for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TCHH gene: 
    NM_007113.3  

    Unigene Cluster for TCHH:

    Trichohyalin
    Hs.432416  [show with all ESTs]
    Unigene Representative Sequence: NM_007113
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368804(uc001ezp.2 uc009wne.1)
    miRNA
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    hsa-miR-4265 hsa-miR-3065-5p hsa-miR-944 hsa-miR-3133 hsa-miR-1305 hsa-miR-211 hsa-miR-188-3p hsa-miR-204
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      QuantiFast Probe-based Assays in human, mouse, rat TCHH

    Additional mRNA sequence: 

    AK307946.1 AY827491.1 BC131826.1 BC131827.1 

    6 DOTS entries:

    DT.95075237  DT.121404966  DT.121404963  DT.121404964  DT.91929314  DT.121404969 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCHH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAATAAT
    TCHH Expression
    About this image


    TCHH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Hair (Integumentary System)    fully expand to see all 5 entries
             Fetal Medulla Cells Hair Shaft
     
     Epithelial Cells
             Fetal Medulla Cells Hair Shaft
     
     Epidermis (Integumentary System)
             Corneocytes Stratified Epidermis
    TCHH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCHH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.432416

    UniProtKB/Swiss-Prot: TRHY_HUMAN, Q07283
    Tissue specificity: Found in the hard keratinizing tissues such as the inner root sheath (IRS) of hair follicles
    and medulla, and in the filiform papillae of dorsal tongue epithelium

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TCHH gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tchh5 trichohyalin   --   3 (40.51 cM) 93442330 
    chicken
    (Gallus gallus)
    Aves CRNN6
    Gallus gallus cornulin (CRNN), mRNA.
    16(a)
    1 → many
    25(1132880-1134156)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    19(a)
    1 → many
    GL343369.1(7-2795)


    ENSEMBL Gene Tree for TCHH (if available)
    TreeFam Gene Tree for TCHH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCHH gene
    RPTN2  FLG22  HRNR2  CRNN2  FLG2  TCHHL12  
    8 SIMAP similar genes for TCHH using alignment to 3 protein entries:     TRHY_HUMAN (see all proteins):
    S100A11    S100B    S100P    S100A10    S100Z    S100A12
    S100A8    S100A4

    TCHH for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCHH (see all 471)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425747251,2
    --152078503(+) ATGACC/TAGTGA 1 -- ds50010--------
    rs2020668071,2
    --152078669(+) CTCCC-/CTCTTTT 1 -- ds50010--------
    rs1509651461,2
    C--152078722(+) GATTGC/GGAACT 1 -- ds50010--------
    rs1143511281,2
    C,F--152078882(+) AATGAT/CTGTGG 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs1882689231,2
    --152078918(+) CTAGAA/GATTTG 1 -- ut310--------
    rs1915813131,2
    --152078999(+) GTAAGA/GCAGAT 1 -- ut310--------
    rs1395078251,2
    --152079077(+) ACTCAA/TCAAAA 1 -- ut310--------
    rs790905681,2
    C--152079233(+) AATCT-/AGATCAAA 1 -- cds10--------
    rs90501,2
    C,F,O,H--152079314(-) AGGGGG/TAGTGA 1 -- ut31 ese316Minor allele frequency- T:0.04MN EA NS NA 1976
    rs120733641,2
    C,F--152079322(+) CCTGCA/CCTATT 1 -- ut31 ese31Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for TCHH (152078793 - 152086556 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TCHH (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717984CNV Deletion23290073
    esv2718040CNV Deletion23290073
    dgv48e201CNV Deletion23290073
    esv1225012CNV Deletion17803354
    esv2717995CNV Deletion23290073
    esv2718062CNV Deletion23290073
    esv2815CNV Deletion18987735
    esv2666434CNV Deletion23128226
    esv2718006CNV Deletion23290073
    esv2718073CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 190370    OMIM disorders: --

    16 diseases for TCHH:    
    About MalaCards
    brown-sequard syndrome    tabes dorsalis    anterior spinal artery syndrome    pilomatrixoma
    reticulosarcoma    monilethrix    alopecia areata    epidermolytic hyperkeratosis
    alopecia    keratoderma    skin disease    down syndrome
    basal cell carcinoma    keratosis    papilloma    infertility

    1 disease from the University of Copenhagen DISEASES database for TCHH:
    Pilomatrixoma

    TCHH for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for TCHH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pilomatricoma 66 3 10228630 (2), 8734653 (1)
    carcinoma basal cell 44.7 1 10228630 (1)
    epidermoid cyst 42.9 1 8453573 (1)
    skin diseases 31.4 3 10439242 (1), 7532602 (1), 10228630 (1)
    carcinoma squamous cell 0 1 10228630 (1)
    tumors 0 2 10072881 (1), 8453573 (1)

    Genetic Association Database (GAD): TCHH
    Human Genome Epidemiology (HuGE) Navigator: TCHH (2 documents)

    Export disorders for TCHH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCHH gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with TCHH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross- linking) protein. (PubMed id 7685034)1, 2, 9 Lee S.-C....Steinert P.M. (J. Biol. Chem. 1993)
    2. Trichohyalin: a structural protein of hair, tongue, nail, and epidermis. (PubMed id 7686953)1, 2, 9 O'Keefe E.J.... Steinert P.M. (J. Invest. Dermatol. 1993)
    3. Common variants in the trichohyalin gene are associated with straight hair in Europeans. (PubMed id 19896111)1, 4, 9 Medland S.E....Martin N.G. (Am. J. Hum. Genet. 2009)
    4. Mapping of the trichohyalin gene: co-localization with the profilaggrin, involucrin, and loricrin genes. (PubMed id 1431214)1, 3 Fietz M.J....Sutherland G.R. (J. Invest. Dermatol. 1992)
    5. Molecular elements of the regulatory control of keratin filament modulator AHF/trichohyalin in the hair follicle. (PubMed id 18643848)1, 9 Yamamoto S....Hirai Y. (Exp. Dermatol. 2009)
    6. Human trichohyalin gene is clustered with the genes for other epidermal structural proteins and calcium-binding proteins at chromosomal locus 1q21. (PubMed id 8423399)1, 9 Lee S.C....Steinert P.M. (J. Invest. Dermatol. 1993)
    7. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    8. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (Nature 2011)
    9. Web-based, participant-driven studies yield novel genetic associations for common traits. (PubMed id 20585627)1 Eriksson N....Mountain J. (PLoS Genet. 2010)
    10. Trichohyalin is a potential major autoantigen in human alopecia areata. (PubMed id 20722389)1 Leung M.C....Tobin D.J. (J. Proteome Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7062 HGNC: 11791 Ensembl:ENSG00000159450 euGenes: HUgn7062 ECgene: TCHH
    H-InvDB: TCHH

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCHH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for TCHH gene:
    Search GeneIP for patents involving TCHH

    GeneCards and IP:
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