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Aliases for TCFL5 Gene

Aliases for TCFL5 Gene

  • Transcription Factor Like 5 2 3 5
  • Transcription Factor-Like 5 (Basic Helix-Loop-Helix) 2 3
  • HPV-16 E2-Binding Protein 1 3 4
  • Cha Transcription Factor 3 4
  • E2BP-1 3 4
  • CHA 3 4
  • Spermatogenesis- And Oogenesis-Specific BHLH-Containing Protein 1 3
  • Transcription Factor-Like 5 Protein 3
  • HPV-16 E2 Binding Protein 1 2
  • BHLHe82 3
  • Figlb 3
  • SOSF1 3
  • E2BP1 4

External Ids for TCFL5 Gene

Previous GeneCards Identifiers for TCFL5 Gene

  • GC20M061349
  • GC20M061309
  • GC20M062151
  • GC20M062198
  • GC20M060942
  • GC20M061472
  • GC20M058190

Summaries for TCFL5 Gene

GeneCards Summary for TCFL5 Gene

TCFL5 (Transcription Factor Like 5) is a Protein Coding gene. Diseases associated with TCFL5 include Chagas Disease and Bile Duct Adenocarcinoma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity.

UniProtKB/Swiss-Prot for TCFL5 Gene

  • Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCFL5 Gene

Genomics for TCFL5 Gene

Regulatory Elements for TCFL5 Gene

Enhancers for TCFL5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G062898 1.5 Ensembl ENCODE dbSUPER 11.5 -38.2 -38169 3.5 HDGF FOXA2 AGO1 ZFP64 ARID4B SIN3A YBX1 FEZF1 ZNF143 ZNF207 DIDO1 GID8 TCFL5 SLC17A9 ENSG00000273759 ARF4P2
GH20G062913 1.5 Ensembl ENCODE dbSUPER 11.4 -53.3 -53333 4.0 HDGF FOXA2 ATF1 MLX ARID4B DMAP1 YBX1 ZNF48 ZNF121 SLC30A9 DIDO1 GID8 TCFL5 TNFRSF6B SLC17A9 ENSG00000273759 ARF4P2
GH20G062814 1.5 Ensembl ENCODE dbSUPER 11.3 +44.1 44097 5.9 PKNOX1 MLX AGO1 ZFP64 ARID4B DMAP1 ZNF48 ZNF121 GLIS2 ZNF143 COL9A3 RTEL1 TCFL5 TNFRSF6B ENSG00000223669 OGFR DPH3P1
GH20G062845 0.8 dbSUPER 18.4 +14.9 14875 3.2 HDGF CTCF PKNOX1 KLF1 ZNF146 ZIC2 ZNF2 RAD21 ZKSCAN1 HIC1 TCFL5 LAMA5 GC20P062845 LOC105372717
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCFL5 on UCSC Golden Path with GeneCards custom track

Promoters for TCFL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TCFL5 Gene

62,841,014 bp from pter
62,861,763 bp from pter
20,750 bases
Minus strand

Genomic View for TCFL5 Gene

Genes around TCFL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCFL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCFL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCFL5 Gene

Proteins for TCFL5 Gene

  • Protein details for TCFL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor-like 5 protein
    Protein Accession:
    Secondary Accessions:
    • O94771
    • Q9BYW0

    Protein attributes for TCFL5 Gene

    500 amino acids
    Molecular mass:
    52697 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.
    • Antibodies against TCFL5 are present in sera from patients with Chagas disease, an autoimmune disease caused by Trypanosoma cruzi. Two different epitopes that mimic Trypanosoma cruzi antigens have been identified: R1 and R3 epitopes, which are recognized by T- and B-cells, respectively.
    • Sequence=BAA36557.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TCFL5 Gene


neXtProt entry for TCFL5 Gene

Post-translational modifications for TCFL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCFL5 Gene

No data available for DME Specific Peptides for TCFL5 Gene

Domains & Families for TCFL5 Gene

Gene Families for TCFL5 Gene

Protein Domains for TCFL5 Gene

Suggested Antigen Peptide Sequences for TCFL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TCFL5: view

No data available for UniProtKB/Swiss-Prot for TCFL5 Gene

Function for TCFL5 Gene

Molecular function for TCFL5 Gene

GENATLAS Biochemistry:
transcription factor-like 5,specifically expressed in cell nuclei of primary spermatocytes
UniProtKB/Swiss-Prot Function:
Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.

Gene Ontology (GO) - Molecular Function for TCFL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,IDA 9763657
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9763657
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with TCFL5: view
genes like me logo Genes that share phenotypes with TCFL5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCFL5 Gene

Localization for TCFL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCFL5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCFL5 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
mitochondrion 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TCFL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001673 male germ cell nucleus IEA --
GO:0005634 nucleus IDA,IEA 9763657
genes like me logo Genes that share ontologies with TCFL5: view

Pathways & Interactions for TCFL5 Gene

SuperPathways for TCFL5 Gene

No Data Available

Interacting Proteins for TCFL5 Gene

SIGNOR curated interactions for TCFL5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TCFL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA,IEA 9763657
GO:0006366 transcription from RNA polymerase II promoter TAS 9763657
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEP 9763657
genes like me logo Genes that share ontologies with TCFL5: view

No data available for Pathways by source for TCFL5 Gene

Drugs & Compounds for TCFL5 Gene

No Compound Related Data Available

Transcripts for TCFL5 Gene

Unigene Clusters for TCFL5 Gene

Transcription factor-like 5 (basic helix-loop-helix):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCFL5 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - - - -
SP4: - -

Relevant External Links for TCFL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCFL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCFL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCFL5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.0).

Protein differential expression in normal tissues from HIPED for TCFL5 Gene

This gene is overexpressed in Testis (52.3) and Kidney (16.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TCFL5 Gene

Protein tissue co-expression partners for TCFL5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCFL5 Gene:


SOURCE GeneReport for Unigene cluster for TCFL5 Gene:


mRNA Expression by UniProt/SwissProt for TCFL5 Gene:

Tissue specificity: Isoform 3 is testis specific. Isoform 2 is pancreas specific.

Evidence on tissue expression from TISSUES for TCFL5 Gene

  • Blood(4.7)
  • Intestine(3)
  • Nervous system(2.9)
  • Gall bladder(2.8)
  • Heart(2.6)
  • Eye(2.5)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with TCFL5: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TCFL5 Gene

Orthologs for TCFL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCFL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TCFL5 34 35
  • 99.5 (n)
(Bos Taurus)
Mammalia TCFL5 35
  • 90 (a)
(Canis familiaris)
Mammalia TCFL5 34 35
  • 85.84 (n)
(Mus musculus)
Mammalia Tcfl5 34 16 35
  • 85.65 (n)
(Rattus norvegicus)
Mammalia Tcfl5 34
  • 85.22 (n)
(Monodelphis domestica)
Mammalia TCFL5 35
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia TCFL5 35
  • 62 (a)
(Gallus gallus)
Aves TCFL5 34 35
  • 65.02 (n)
(Anolis carolinensis)
Reptilia TCFL5 35
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tcfl5 34
  • 57.53 (n)
Species where no ortholog for TCFL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCFL5 Gene

Gene Tree for TCFL5 (if available)
Gene Tree for TCFL5 (if available)

Paralogs for TCFL5 Gene

No data available for Paralogs for TCFL5 Gene

Variants for TCFL5 Gene

Sequence variations from dbSNP and Humsavar for TCFL5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs115193255 Likely benign 62,840,866(+) TGGAC(A/G)CGCGG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs116108376 Likely benign 62,840,741(+) TCAAC(A/G)TGAGG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs34911725 Likely benign 62,840,687(-) AACAC(A/G)GCTCC downstream-variant-500B, reference, synonymous-codon
rs41310201 Likely benign 62,840,960(+) ATTTG(A/C/G)GAGAA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs6512320 Likely benign 62,840,895(+) CTCAT(C/T)GGGCT intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TCFL5 Gene

Variant ID Type Subtype PubMed ID
dgv2289n106 CNV deletion 24896259
esv2670154 CNV deletion 23128226
esv3304380 CNV mobile element insertion 20981092
esv3346142 CNV insertion 20981092
esv3646297 CNV loss 21293372
esv3646298 CNV loss 21293372
nsv1072134 CNV deletion 25765185
nsv1131600 CNV deletion 24896259
nsv428380 CNV loss 18775914
nsv828794 CNV loss 20364138
nsv834027 CNV loss 17160897
nsv953303 CNV deletion 24416366
nsv9825 CNV gain 18304495

Variation tolerance for TCFL5 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCFL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCFL5 Gene

Disorders for TCFL5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TCFL5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chagas disease
  • american trypanosomiasis
bile duct adenocarcinoma
  • enterobius vermicularis infection
- elite association - COSMIC cancer census association via MalaCards
Search TCFL5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCFL5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TCFL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCFL5 Gene

Publications for TCFL5 Gene

  1. Cloning of TCFL5 encoding a novel human basic helix-loop-helix motif protein that is specifically expressed in primary spermatocytes at the pachytene stage. (PMID: 9763657) Maruyama O. … Nakamura Y. (Cytogenet. Cell Genet. 1998) 2 3 4 22 64
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  3. Dominant T- and B-cell epitopes in an autoantigen linked to Chagas' disease. (PMID: 11306602) Girones N. … Fresno M. (J. Clin. Invest. 2001) 3 4 64
  4. PCR based detection of HPV 16 and 18 genotypes in normal oral mucosa of tobacco users and non-users. (PMID: 24588599) Pattanshetty S. … Babji D. (Biotech Histochem 2014) 3 64
  5. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PMID: 22360420) Martins-de-Souza D. … Bahn S. (J. Proteome Res. 2012) 3 64

Products for TCFL5 Gene

Sources for TCFL5 Gene

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