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Aliases for TCFL5 Gene

Aliases for TCFL5 Gene

  • Transcription Factor Like 5 2 3 5
  • Transcription Factor-Like 5 (Basic Helix-Loop-Helix) 2 3
  • HPV-16 E2-Binding Protein 1 3 4
  • Cha Transcription Factor 3 4
  • E2BP-1 3 4
  • CHA 3 4
  • Spermatogenesis- And Oogenesis-Specific BHLH-Containing Protein 1 3
  • Transcription Factor-Like 5 Protein 3
  • HPV-16 E2 Binding Protein 1 2
  • BHLHe82 3
  • Figlb 3
  • SOSF1 3
  • E2BP1 4

External Ids for TCFL5 Gene

Previous GeneCards Identifiers for TCFL5 Gene

  • GC20M061349
  • GC20M061309
  • GC20M062151
  • GC20M062198
  • GC20M060942
  • GC20M061472
  • GC20M058190

Summaries for TCFL5 Gene

GeneCards Summary for TCFL5 Gene

TCFL5 (Transcription Factor Like 5) is a Protein Coding gene. Diseases associated with TCFL5 include Chagas Disease and Bile Duct Adenocarcinoma. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein dimerization activity.

UniProtKB/Swiss-Prot for TCFL5 Gene

  • Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.

Additional gene information for TCFL5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCFL5 Gene

Genomics for TCFL5 Gene

GeneHancer (GH) Regulatory Elements for TCFL5 Gene

Promoters and enhancers for TCFL5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I062860 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 567.9 +0.1 86 2.9 HDGF PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 TCFL5 LOC105372717
GH20I062641 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 9.8 +216.4 216381 8 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 SLCO4A1 MRGBP TAF4 GMEB2 SLCO4A1-AS1 OGFR OGFR-AS1 MIR1-1 MIR1-1HG MIR1-1HG-AS1
GH20I062814 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 11.3 +44.1 44096 5.9 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF121 GLIS2 FOS COL9A3 TCFL5 ENSG00000223669 OGFR DPH3P1
GH20I062898 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.5 -38.2 -38168 3.5 HDGF CLOCK FOXA2 ZFP64 ARID4B SIN3A YBX1 FEZF1 IRF4 POLR2B DIDO1 RTEL1 TAF4 YTHDF1 ARFGAP1 GID8 TCFL5 TNFRSF6B GMEB2 ARFRP1
GH20I062913 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.4 -53.3 -53332 4 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 SLC30A9 ZNF121 DIDO1 GID8 TCFL5 SLC17A9 ENSG00000273759 ARF4P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCFL5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCFL5 gene promoter:

Genomic Locations for TCFL5 Gene

Genomic Locations for TCFL5 Gene
chr20:62,841,014-62,861,763
(GRCh38/hg38)
Size:
20,750 bases
Orientation:
Minus strand
chr20:61,472,467-61,493,115
(GRCh37/hg19)

Genomic View for TCFL5 Gene

Genes around TCFL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCFL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCFL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCFL5 Gene

Proteins for TCFL5 Gene

  • Protein details for TCFL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL49-TCFL5_HUMAN
    Recommended name:
    Transcription factor-like 5 protein
    Protein Accession:
    Q9UL49
    Secondary Accessions:
    • O94771
    • Q9BYW0

    Protein attributes for TCFL5 Gene

    Size:
    500 amino acids
    Molecular mass:
    52697 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.
    Miscellaneous:
    • Antibodies against TCFL5 are present in sera from patients with Chagas disease, an autoimmune disease caused by Trypanosoma cruzi. Two different epitopes that mimic Trypanosoma cruzi antigens have been identified: R1 and R3 epitopes, which are recognized by T- and B-cells, respectively.
    SequenceCaution:
    • Sequence=BAA36557.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TCFL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCFL5 Gene

Post-translational modifications for TCFL5 Gene

No Post-translational modifications

Other Protein References for TCFL5 Gene

No data available for DME Specific Peptides for TCFL5 Gene

Domains & Families for TCFL5 Gene

Gene Families for TCFL5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TCFL5 Gene

Suggested Antigen Peptide Sequences for TCFL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TCFL5: view

No data available for UniProtKB/Swiss-Prot for TCFL5 Gene

Function for TCFL5 Gene

Molecular function for TCFL5 Gene

GENATLAS Biochemistry:
transcription factor-like 5,specifically expressed in cell nuclei of primary spermatocytes
UniProtKB/Swiss-Prot Function:
Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.

Phenotypes From GWAS Catalog for TCFL5 Gene

Gene Ontology (GO) - Molecular Function for TCFL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 12923186
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 12923186
GO:0003677 DNA binding IDA,IEA 9763657
GO:0003700 DNA binding transcription factor activity TAS 9763657
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with TCFL5: view
genes like me logo Genes that share phenotypes with TCFL5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCFL5 Gene

Localization for TCFL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCFL5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCFL5 gene
Compartment Confidence
nucleus 5
golgi apparatus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TCFL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001673 male germ cell nucleus IEA --
GO:0005634 nucleus IEA,IDA 9763657
genes like me logo Genes that share ontologies with TCFL5: view

Pathways & Interactions for TCFL5 Gene

SuperPathways for TCFL5 Gene

No Data Available

Interacting Proteins for TCFL5 Gene

SIGNOR curated interactions for TCFL5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TCFL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 12923186
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 9763657
GO:0006366 transcription by RNA polymerase II TAS 9763657
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with TCFL5: view

No data available for Pathways by source for TCFL5 Gene

Drugs & Compounds for TCFL5 Gene

No Compound Related Data Available

Transcripts for TCFL5 Gene

Unigene Clusters for TCFL5 Gene

Transcription factor-like 5 (basic helix-loop-helix):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCFL5 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - - - -
SP3:
SP4: - -
SP5:

Relevant External Links for TCFL5 Gene

GeneLoc Exon Structure for
TCFL5
ECgene alternative splicing isoforms for
TCFL5

Expression for TCFL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCFL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCFL5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.0).

Protein differential expression in normal tissues from HIPED for TCFL5 Gene

This gene is overexpressed in Testis (52.3) and Kidney (16.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TCFL5 Gene



Protein tissue co-expression partners for TCFL5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCFL5 Gene:

TCFL5

SOURCE GeneReport for Unigene cluster for TCFL5 Gene:

Hs.126248

mRNA Expression by UniProt/SwissProt for TCFL5 Gene:

Q9UL49-TCFL5_HUMAN
Tissue specificity: Isoform 3 is testis specific. Isoform 2 is pancreas specific.

Evidence on tissue expression from TISSUES for TCFL5 Gene

  • Blood(4.7)
  • Intestine(3)
  • Nervous system(3)
  • Gall bladder(2.8)
  • Heart(2.6)
  • Eye(2.5)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with TCFL5: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TCFL5 Gene

Orthologs for TCFL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCFL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCFL5 34 33
  • 99.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TCFL5 34
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCFL5 34 33
  • 85.84 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tcfl5 33 16 34
  • 85.65 (n)
rat
(Rattus norvegicus)
Mammalia Tcfl5 33
  • 85.22 (n)
oppossum
(Monodelphis domestica)
Mammalia TCFL5 34
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCFL5 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCFL5 34 33
  • 65.02 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCFL5 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcfl5 33
  • 57.53 (n)
Species where no ortholog for TCFL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCFL5 Gene

ENSEMBL:
Gene Tree for TCFL5 (if available)
TreeFam:
Gene Tree for TCFL5 (if available)

Paralogs for TCFL5 Gene

No data available for Paralogs for TCFL5 Gene

Variants for TCFL5 Gene

Sequence variations from dbSNP and Humsavar for TCFL5 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1011451878 uncertain-significance, Multiple Epiphyseal Dysplasia, Dominant 62,841,008(-) G/A/C downstream_transcript_variant
rs1048100 benign, not specified, Multiple Epiphyseal Dysplasia, Dominant 62,840,721(-) C/A/G/T downstream_transcript_variant
rs1048132 benign, Multiple Epiphyseal Dysplasia, Dominant 62,841,088(-) C/G/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1055327177 uncertain-significance, Multiple Epiphyseal Dysplasia, Dominant 62,840,850(-) C/T downstream_transcript_variant
rs115193255 likely-benign, Multiple Epiphyseal Dysplasia, Dominant 62,840,866(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TCFL5 Gene

Variant ID Type Subtype PubMed ID
dgv2289n106 CNV deletion 24896259
esv2670154 CNV deletion 23128226
esv3304380 CNV mobile element insertion 20981092
esv3346142 CNV insertion 20981092
esv3646297 CNV loss 21293372
esv3646298 CNV loss 21293372
nsv1072134 CNV deletion 25765185
nsv1131600 CNV deletion 24896259
nsv428380 CNV loss 18775914
nsv828794 CNV loss 20364138
nsv834027 CNV loss 17160897
nsv953303 CNV deletion 24416366
nsv9825 CNV gain 18304495

Variation tolerance for TCFL5 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCFL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCFL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCFL5 Gene

Disorders for TCFL5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TCFL5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chagas disease
  • american trypanosomiasis
bile duct adenocarcinoma
enterobiasis
  • enterobius vermicularis infection
- elite association - COSMIC cancer census association via MalaCards
Search TCFL5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TCFL5

genes like me logo Genes that share disorders with TCFL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCFL5 Gene

Publications for TCFL5 Gene

  1. Cloning of TCFL5 encoding a novel human basic helix-loop-helix motif protein that is specifically expressed in primary spermatocytes at the pachytene stage. (PMID: 9763657) Maruyama O … Nakamura Y (Cytogenetics and cell genetics 1998) 2 3 4 22 58
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  3. Dominant T- and B-cell epitopes in an autoantigen linked to Chagas' disease. (PMID: 11306602) Gironès N … Fresno M (The Journal of clinical investigation 2001) 3 4 58
  4. PCR based detection of HPV 16 and 18 genotypes in normal oral mucosa of tobacco users and non-users. (PMID: 24588599) Pattanshetty S … Babji D (Biotechnic & histochemistry : official publication of the Biological Stain Commission 2014) 3 58
  5. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PMID: 22360420) Martins-de-Souza D … Bahn S (Journal of proteome research 2012) 3 58

Products for TCFL5 Gene

Sources for TCFL5 Gene

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