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TCFL5 Gene

protein-coding   GIFtS: 50
GCID: GC20M061472

Transcription Factor-Like 5 (Basic Helix-Loop-Helix)

  Search for TCFL5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Factor-Like 5 (Basic Helix-Loop-Helix)1 2     HPV-16 E2-Binding Protein 12 3
HPV-16 E2 Binding Protein 11 2     Figlb2
Cha Transcription Factor2 3     bHLHe822
CHA2 3     Transcription Factor-Like 5 Protein2
E2BP-12 3     E2BP13

External Ids:    HGNC: 116461   Entrez Gene: 107322   Ensembl: ENSG000001011907   OMIM: 6047455   UniProtKB: Q9UL493   

Export aliases for TCFL5 gene to outside databases

Previous GC identifers: GC20M061349 GC20M061309 GC20M062151 GC20M062198 GC20M060942 GC20M058190


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TCFL5 Gene:
TCFL5 (transcription factor-like 5 (basic helix-loop-helix)) is a protein-coding gene. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: TCFL5_HUMAN, Q9UL49
Function: Putative transcription factor. Isoform 3 may play a role in early spermatogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCFL5 gene promoter:
         ER-alpha   AML1a   POU3F1   CREB   POU2F1   deltaCREB   POU2F1a   FOXJ2 (long isoform)   SEF-1 (1)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCFL5 promoter sequence
   Search Chromatin IP Primers for TCFL5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCFL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

TCFL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCFL5 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M061472:  view genomic region     (about GC identifiers)

Start:
61,472,467 bp from pter      End:
61,493,115 bp from pter
Size:
20,649 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCFL5_HUMAN, Q9UL49 (See protein sequence)
Recommended Name: Transcription factor-like 5 protein  
Size: 500 amino acids; 52697 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein
Developmental stage: Isoform 3 is specifically expressed in primary spermatocytes at the pachytene stage, but not
those at leptonema stage. Not expressed in other testicular cells, including spermatogonia located in the basal
compartment of the seminiferous tubule or spermatids
Miscellaneous: Antibodies against TCFL5 are present in sera from patients with Chagas' disease, an autoimmune
disease caused by Trypanosoma cruzi. Two different epitopes that mimic Trypanosoma cruzi antigens have been
identified: R1 and R3 epitopes, which are recognized by T- and B-cells, respectively
Sequence caution: Sequence=BAA36557.1; Type=Erroneous initiation;
Secondary accessions: O94771 Q9BYW0
Alternative splicing: 3 isoforms:  Q9UL49-3   Q9UL49-1   Q9UL49-2   

Explore the universe of human proteins at neXtProt for TCFL5: NX_Q9UL49

Explore proteomics data for TCFL5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TCFL5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006593.2  
    ENSEMBL proteins: 
     ENSP00000334294   ENSP00000217162  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q9UL49

    ProtoNet protein and cluster: Q9UL49

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: TCFL5_HUMAN, Q9UL49
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with TCFL5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCFL5_HUMAN, Q9UL49
    Function: Putative transcription factor. Isoform 3 may play a role in early spermatogenesis

         Genatlas biochemistry entry for TCFL5:
    transcription factor-like 5,specifically expressed in cell nuclei of primary spermatocytes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA9763657
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9763657
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with TCFL5           About GenesLikeMe


    Animal Models:
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    hsa-mir-193b-3p (MIRT041545), hsa-mir-331-3p (MIRT043570), hsa-mir-16-5p (MIRT051271), hsa-mir-215-5p (MIRT024939), hsa-mir-192-5p (MIRT026827)

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    hsa-miR-577 hsa-miR-144 hsa-miR-875-3p hsa-miR-1265 hsa-miR-96* hsa-miR-16-1* hsa-miR-570 hsa-miR-1289
    SwitchGear 3'UTR luciferase reporter plasmidTCFL5 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCFL5_HUMAN, Q9UL49: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001673male germ cell nucleus IEA--
    GO:0005634nucleus IDA9763657

    Find genes that share ontologies with TCFL5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCFL5
    Interactions:

        GeneGlobe Interaction Network for TCFL5

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TCFL5 (Q9UL493 ENSP000003342944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOPBP1Q925473, ENSP000002608104I2D: score=1 STRING: ENSP00000260810
    USF1P224153, ENSP000003569994I2D: score=1 STRING: ENSP00000356999
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IDA9763657
    GO:0006366transcription from RNA polymerase II promoter TAS9763657
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEP9763657
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with TCFL5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCFL5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TCFL5 gene: 
    NM_006602.2  

    Unigene Cluster for TCFL5:

    Transcription factor-like 5 (basic helix-loop-helix)
    Hs.126248  [show with all ESTs]
    Unigene Representative Sequence: BC065520
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335351(uc002ydo.3 uc002ydp.3) ENST00000217162(uc002ydq.3)

    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate TCFL5:
    hsa-miR-577 hsa-miR-144 hsa-miR-875-3p hsa-miR-1265 hsa-miR-96* hsa-miR-16-1* hsa-miR-570 hsa-miR-1289
    SwitchGear 3'UTR luciferase reporter plasmidTCFL5 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat TCFL5
      QuantiFast Probe-based Assays in human, mouse, rat TCFL5

    Additional mRNA sequence: 

    AB012124.1 AF070992.1 BC015689.2 BC046933.1 BC065520.1 

    13 DOTS entries:

    DT.75107208  DT.100775935  DT.402827  DT.91958693  DT.100775939  DT.97834961  DT.414372  DT.40211115 
    DT.86858197  DT.92015104  DT.97774279  DT.100746963  DT.86855476 

    Selected AceView cDNA sequences (see all 136):

    CA417679 CA431192 BQ637205 AI222718 BQ709994 BU739535 BU617805 NM_006602 
    BU741548 BE302044 BQ448177 CA419503 BQ718487 AW337242 AI870834 AI884611 
    N34445 BX282585 AI364770 CR621094 AW451768 AL040903 AA398861 CA429209 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TCFL5    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
    SP1:        -                                                                           
    SP2:                                                  -     -     -     -               
    SP3:                                                                                    
    SP4:                                                  -     -                           
    SP5:                                                                                    


    ECgene alternative splicing isoforms for TCFL5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCFL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TCFL5 Expression
    About this image


    TCFL5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
     
     Testis (Reproductive System)
    TCFL5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCFL5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.126248

    UniProtKB/Swiss-Prot: TCFL5_HUMAN, Q9UL49
    Tissue specificity: Isoform 3 is testis specific. Isoform 2 is pancreas specific

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TCFL5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcfl51 , 5 transcription factor-like 5 (basic helix-loop-helix)1, 5 85.65(n)1
    85.87(a)1
      2 (103.16 cM)5
    2773531  NM_178254.31  NP_839985.21 
     1806219565 
    chicken
    (Gallus gallus)
    Aves TCFL51 transcription factor-like 5 (basic helix-loop-helix) 65.02(n)
    60.45(a)
      771446  XM_001234726.2  XP_001234727.1 
    lizard
    (Anolis carolinensis)
    Reptilia TCFL56
    transcription factor-like 5 (basic helix-loop-heli...
    60(a)
    1 ↔ 1
    4(152496611-152508354)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tcfl51 transcription factor-like 5 (basic helix-loop-helix) 57.53(n)
    49.81(a)
      100493147  XM_002943199.2  XP_002943245.2 
    rice
    (Oryza sativa)
    Liliopsida AK106036.12   -- 70.39(n)    AK106036.1 


    ENSEMBL Gene Tree for TCFL5 (if available)
    TreeFam Gene Tree for TCFL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCFL5 (see all 690)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1132194161,2
    C--61431178(+) CTCACC/TTTTCT 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1901871461,2
    C--61431191(+) TCTGTC/TCCAAG 1 -- ds50010--------
    rs748303511,2
    C,F--61431228(+) AAGGAC/TGGCCA 1 -- ds50013Minor allele frequency- T:0.01NA EU 5762
    rs1444071741,2
    F--61431229(+) AGGACA/GGCCAG 1 -- ds50011Minor allele frequency- C:0.00NA 4308
    rs349901151,2
    C--61431238(-) AGCACC/TGTCCT 1 -- ds50011Minor allele frequency- T:0.01NA 78
    rs349117251,2
    C,F--61431342(-) AACACG/AGCTCC 1 -- ds50013Minor allele frequency- A:0.01NA EU 3393
    rs1489393431,2
    C--61431343(+) GAGCCG/ATGTTA 1 -- ds50011Minor allele frequency- A:0.00NA 3124
    rs10481001,2
    C,F,H--61431376(+) GCTCTC/AGAAGC 1 -- ds500123Minor allele frequency- A:0.17MN NS EA NA WA CSA 5169
    rs2016547741,2
    C--61431395(+) TTCAAC/TGTGAG 1 -- ds50010--------
    rs1161083761,2
    C,F--61431396(+) TCAACG/ATGAGG 1 -- ds50011Minor allele frequency- A:0.06WA 118

    HapMap Linkage Disequilibrium report for TCFL5 (61472467 - 61493115 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TCFL5 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670154CNV Deletion23128226
    esv268658CNV Insertion20981092
    nsv428380CNV Loss18775914
    nsv913073CNV Loss21882294
    dgv4614n71CNV Loss21882294
    nsv834027CNV Loss17160897
    nsv913127CNV Loss21882294
    dgv4603n71CNV Loss21882294
    nsv913124CNV Loss21882294
    nsv828794CNV Loss20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604745    OMIM disorders: --


    Find genes that share disorders with TCFL5           About GenesLikeMe


    Export disorders for TCFL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCFL5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TCFL5)
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    1. Cloning of TCFL5 encoding a novel human basic helix-loop-helix motif protein that is specifically expressed in primary spermatocytes at the pachytene stage. (PubMed id 9763657)1, 2, 3, 9 Maruyama O.... Nakamura Y. (Cytogenet. Cell Genet. 1998)
    2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    3. Dominant T- and B-cell epitopes in an autoantigen linked to Chagas' disease. (PubMed id 11306602)1, 2 Girones N.... Fresno M. (J. Clin. Invest. 2001)
    4. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (J. Proteome Res. 2012)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    6. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    7. Regulation of TopBP1 oligomerization by Akt/PKB for cell survival. (PubMed id 17006541)1 Liu K....Lin W.C. (EMBO J. 2006)
    8. Cha, a basic helix-loop-helix transcription factor involved in the regulation of upstream stimulatory factor activity. (PubMed id 12923186)1 RodrA-guez C.I....Fresno M. (J. Biol. Chem. 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Identification of differentially expressed genes involved in the formation of multicellular tumor spheroids by HT-29 colon carcinoma cells. (PubMed id 17164780)9 Dardousis K....Sachinidis A. (Mol. Ther. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10732 HGNC: 11646 AceView: TCFL5 Ensembl:ENSG00000101190 euGenes: HUgn10732
    ECgene: TCFL5 H-InvDB: TCFL5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCFL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCFL5 gene:
    Search GeneIP for patents involving TCFL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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