Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TCF7L2 Gene

Aliases for TCF7L2 Gene

  • Transcription Factor 7 Like 2 2 3 5
  • Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) 2 3
  • T-Cell-Specific Transcription Factor 4 3 4
  • HMG Box Transcription Factor 4 3 4
  • T-Cell Factor 4 3 4
  • HTCF-4 3 4
  • TCF-4 3 4
  • TCF4 3 4
  • Transcription Factor 7-Like 2 3

External Ids for TCF7L2 Gene

Previous HGNC Symbols for TCF7L2 Gene

  • TCF4

Previous GeneCards Identifiers for TCF7L2 Gene

  • GC10P113605
  • GC10P113943
  • GC10P114841
  • GC10P114374
  • GC10P114700
  • GC10P108337
  • GC10P114710

Summaries for TCF7L2 Gene

Entrez Gene Summary for TCF7L2 Gene

  • This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

GeneCards Summary for TCF7L2 Gene

TCF7L2 (Transcription Factor 7 Like 2) is a Protein Coding gene. Diseases associated with TCF7L2 include Diabetes Mellitus, Noninsulin-Dependent and Colorectal Cancer. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is TCF7L1.

UniProtKB/Swiss-Prot for TCF7L2 Gene

  • Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5-CCTTTGATC-3 in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

Gene Wiki entry for TCF7L2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF7L2 Gene

Genomics for TCF7L2 Gene

Regulatory Elements for TCF7L2 Gene

Enhancers for TCF7L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G112985 2.4 FANTOM5 Ensembl ENCODE dbSUPER 19.1 +36.3 36282 1.8 ZSCAN4 ZNF398 IKZF1 ZSCAN5C HMBOX1 ZNF24 KLF7 SPI1 TCF7L2 LOC105378488 RPS15AP30
GH10G113099 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.9 +149.6 149552 0.8 ZSCAN4 ZNF76 KLF17 FEZF1 ZNF2 ZNF366 SCRT2 ZNF680 TSHZ1 ZEB2 TCF7L2 LOC105378488 RPS15AP30 LOC105378489
GH10G113055 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.6 +109.6 109649 9.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 TCF7L2 ZDHHC6 VTI1A LOC105378488 HABP2 RPS15AP30 LOC105378489
GH10G113090 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15 +144.0 143954 6.4 PKNOX1 FOXA2 ATF1 MLX ARID4B FEZF1 TCF12 GTF3C2 ZNF121 GATA2 TCF7L2 ZDHHC6 VTI1A LOC105378488 RPS15AP30 LOC105378489
GH10G113047 1.4 Ensembl ENCODE dbSUPER 18 +98.0 97974 2.3 INSM2 ZNF76 KLF17 FEZF1 ZEB1 ZNF121 ZNF366 ZSCAN5C SCRT2 KLF7 TCF7L2 LOC105378488 RPS15AP30 LOC105378489
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCF7L2 on UCSC Golden Path with GeneCards custom track

Promoters for TCF7L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000033567 1381 4801 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B FOS ZNF263

Genomic Location for TCF7L2 Gene

Chromosome:
10
Start:
112,950,219 bp from pter
End:
113,167,678 bp from pter
Size:
217,460 bases
Orientation:
Plus strand

Genomic View for TCF7L2 Gene

Genes around TCF7L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF7L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF7L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF7L2 Gene

Proteins for TCF7L2 Gene

  • Protein details for TCF7L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQB0-TF7L2_HUMAN
    Recommended name:
    Transcription factor 7-like 2
    Protein Accession:
    Q9NQB0
    Secondary Accessions:
    • B4DRJ8
    • B9X074
    • C6ZRJ8
    • C6ZRK0
    • E2GH14
    • E2GH19
    • E2GH20
    • E2GH24
    • E2GH25
    • E9PFH9
    • F8W742
    • F8W7T5
    • O00185
    • Q9NQB1
    • Q9NQB2
    • Q9NQB3
    • Q9NQB4
    • Q9NQB5
    • Q9NQB6
    • Q9NQB7
    • Q9ULC2

    Protein attributes for TCF7L2 Gene

    Size:
    619 amino acids
    Molecular mass:
    67919 Da
    Quaternary structure:
    • Interacts with TGFB1I1 (By similarity). Interacts with CTNNB1 (via the armadillo repeat); forms stable transcription complex. Interacts with EP300. Interacts with NLK. Interacts with CCDC85B (probably through the HMG box); prevents interaction with CTNNB1. Interacts with TNIK. Interacts with MAD2L2; prevents TCF7L2/TCF4 binding to promZIPK/DAPK3oters, negatively modulating its transcriptional activity. Interacts with ZIPK/DAPK3. Interacts with XIAP/BIRC4 and TLE3. Interacts with DDIT3/CHOP. The CTNNB1 and TCF7L2/TCF4 complex interacts with PML (isoform PML-4). Identified in a complex with CTNNB1 and FERMT2. Interacts with SPIN1.

    Three dimensional structures from OCA and Proteopedia for TCF7L2 Gene

neXtProt entry for TCF7L2 Gene

Post-translational modifications for TCF7L2 Gene

  • In vitro, phosphorylated by TNIK.
  • Phosphorylated at Thr-201 and/or Thr-212 by NLK. Phosphorylation by NLK at these sites inhibits DNA-binding by TCF7L2/TCF4, thereby preventing transcriptional activation of target genes of the canonical Wnt/beta-catenin signaling pathway.
  • Polysumoylated. Sumoylation is enhanced by PIAS family members and desumoylation is enhanced by SENP2. Sumoylation/desumoylation regulates TCF7L2/TCF4 transcription activity in the Wnt/beta-catenin signaling pathway without altering interaction with CTNNB1 nor binding to DNA.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TCF7L2 (TCF7L2)
  • Abcam antibodies for TCF7L2

No data available for DME Specific Peptides for TCF7L2 Gene

Domains & Families for TCF7L2 Gene

Protein Domains for TCF7L2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQB0

UniProtKB/Swiss-Prot:

TF7L2_HUMAN :
  • The promoter-specific activation domain interacts with the transcriptional coactivator EP300.
  • Belongs to the TCF/LEF family.
Domain:
  • The promoter-specific activation domain interacts with the transcriptional coactivator EP300.
Family:
  • Belongs to the TCF/LEF family.
genes like me logo Genes that share domains with TCF7L2: view

No data available for Gene Families for TCF7L2 Gene

Function for TCF7L2 Gene

Molecular function for TCF7L2 Gene

UniProtKB/Swiss-Prot Function:
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5-CCTTTGATC-3 in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

Gene Ontology (GO) - Molecular Function for TCF7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 19443654
GO:0001103 RNA polymerase II repressing transcription factor binding IPI 19443654
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 9727977
GO:0005515 protein binding IPI 11713475
genes like me logo Genes that share ontologies with TCF7L2: view
genes like me logo Genes that share phenotypes with TCF7L2: view

Animal Models for TCF7L2 Gene

MGI Knock Outs for TCF7L2:

Animal Model Products

CRISPR Products

miRNA for TCF7L2 Gene

miRTarBase miRNAs that target TCF7L2
Targeted motifs for TCF7L2 Gene
HOMER Transcription Factor Regulatory Elements motif TCF7L2
  • Consensus sequence: ACATCAAAGGGA Submotif: canonical Cell Type: Hct116 GEO ID: SRA012054

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for TCF7L2 Gene

Localization for TCF7L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF7L2 Gene

Nucleus, PML body. Note=Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCF7L2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TCF7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 19443654
GO:0005634 nucleus IDA,IEA 9065401
GO:0005654 nucleoplasm TAS --
GO:0016605 PML body IEA --
GO:0032993 protein-DNA complex IDA 14661054
genes like me logo Genes that share ontologies with TCF7L2: view

Pathways & Interactions for TCF7L2 Gene

genes like me logo Genes that share pathways with TCF7L2: view

Pathways by source for TCF7L2 Gene

SIGNOR curated interactions for TCF7L2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TCF7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12799378
GO:0001568 blood vessel development IMP 15578569
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA,IEA 9727977
genes like me logo Genes that share ontologies with TCF7L2: view

Drugs & Compounds for TCF7L2 Gene

(13) Drugs for TCF7L2 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporine Approved, Investigational, Vet_approved Pharma Antagonist Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 922
Hydrochlorothiazide Approved, Vet_approved Pharma Inhibition, Inhibitor 413
Repaglinide Approved, Investigational Pharma Kir6 (KATP) channel blocker 51
Sirolimus Approved, Investigational Pharma Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors 1940
Tacrolimus Approved, Investigational Pharma 1102

(7) Additional Compounds for TCF7L2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TCF7L2: view

Transcripts for TCF7L2 Gene

Unigene Clusters for TCF7L2 Gene

Transcription factor 7-like 2 (T-cell specific, HMG-box):
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCF7L2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - -
SP5: -
SP6:
SP7:
SP8: - - - - -
SP9: -
SP10: - - -

ExUns: 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c · 20d · 20e
SP1: -
SP2: - -
SP3: - -
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TCF7L2 Gene

GeneLoc Exon Structure for
TCF7L2
ECgene alternative splicing isoforms for
TCF7L2

Expression for TCF7L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCF7L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TCF7L2 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCF7L2 Gene



Protein tissue co-expression partners for TCF7L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCF7L2 Gene:

TCF7L2

SOURCE GeneReport for Unigene cluster for TCF7L2 Gene:

Hs.593995

mRNA Expression by UniProt/SwissProt for TCF7L2 Gene:

Q9NQB0-TF7L2_HUMAN
Tissue specificity: Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom.

Evidence on tissue expression from TISSUES for TCF7L2 Gene

  • Nervous system(4.8)
  • Intestine(4.5)
  • Liver(4.4)
  • Pancreas(3.1)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with TCF7L2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF7L2 Gene

Orthologs for TCF7L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF7L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF7L2 34 35
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia TCF7L2 34 35
  • 93.63 (n)
mouse
(Mus musculus)
Mammalia Tcf7l2 34 16 35
  • 90.88 (n)
oppossum
(Monodelphis domestica)
Mammalia TCF7L2 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCF7L2 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcf7l2 34
  • 88.95 (n)
cow
(Bos Taurus)
Mammalia TCFL2 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCF7L2 34 35
  • 87.35 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 94 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tcf7l2 34
  • 82.95 (n)
Str.5723 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11987 34
zebrafish
(Danio rerio)
Actinopterygii tcf7l2 34 35
  • 83.3 (n)
tcf4 34
fruit fly
(Drosophila melanogaster)
Insecta pan 36 35
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea pop-1 35
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11069 35
  • 40 (a)
OneToMany
Species where no ortholog for TCF7L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCF7L2 Gene

ENSEMBL:
Gene Tree for TCF7L2 (if available)
TreeFam:
Gene Tree for TCF7L2 (if available)

Paralogs for TCF7L2 Gene

Variants for TCF7L2 Gene

Sequence variations from dbSNP and Humsavar for TCF7L2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs7903146 drug-response 112,998,590(+) AGATA(C/T)TATAT intron-variant
VAR_035939 A colorectal cancer sample
rs11196205 other 113,047,288(+) ACTAC(C/G/T)AGCAG intron-variant
rs12255372 other 113,049,143(+) AGAAT(A/G/T)ACCAT intron-variant
rs1000006717 -- 113,045,628(+) CTGCA(A/G)AGGGC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TCF7L2 Gene

Variant ID Type Subtype PubMed ID
dgv286e212 CNV loss 25503493
dgv41e215 CNV deletion 23714750
dgv518n106 CNV deletion 24896259
esv2074123 CNV deletion 18987734
esv2762881 CNV loss 21179565
esv3546869 CNV deletion 23714750
esv3579130 CNV loss 25503493
esv3624589 CNV loss 21293372
nsv1070891 CNV deletion 25765185
nsv1134056 CNV deletion 24896259
nsv24033 CNV deletion 16902084
nsv437693 CNV loss 16327808
nsv476274 CNV novel sequence insertion 20440878
nsv476737 CNV novel sequence insertion 20440878
nsv527837 CNV loss 19592680
nsv7211 OTHER inversion 18451855
nsv7553 CNV deletion 18451855
nsv982900 CNV duplication 23825009

Variation tolerance for TCF7L2 Gene

Residual Variation Intolerance Score: 11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.27; 76.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCF7L2 Gene

Human Gene Mutation Database (HGMD)
TCF7L2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCF7L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF7L2 Gene

Disorders for TCF7L2 Gene

MalaCards: The human disease database

(10) MalaCards diseases for TCF7L2 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • diabetes, type 2
colorectal cancer
  • colorectal cancer, somatic
tropical calcific pancreatitis
  • fibrocalculous pancreatic diabetes
acute insulin response
gestational diabetes
  • gdm
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TF7L2_HUMAN
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:16415884, ECO:0000269 PubMed:24390345}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Note=Constitutive activation and subsequent transactivation of target genes may lead to the maintenance of stem-cell characteristics (cycling and longevity) in cells that should normally undergo terminal differentiation and constitute the primary transforming event in colorectal cancer (CRC).

Relevant External Links for TCF7L2

Genetic Association Database (GAD)
TCF7L2
Human Genome Epidemiology (HuGE) Navigator
TCF7L2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCF7L2
genes like me logo Genes that share disorders with TCF7L2: view

No data available for Genatlas for TCF7L2 Gene

Publications for TCF7L2 Gene

  1. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. (PMID: 16415884) Grant S.F.A. … Stefansson K. (Nat. Genet. 2006) 3 4 22 46 64
  2. Transcription factor 7-like 2-gene polymorphism is related to fasting C peptide in latent autoimmune diabetes in adults (LADA). (PMID: 19533015) Szepietowska B. … Szelachowska M. (Acta Diabetol 2010) 3 22 46 64
  3. No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue. (PMID: 19895682) Prokunina-Olsson L. … Hall J.L. (Mol. Cancer 2009) 3 22 46 64
  4. Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease. (PMID: 19221600) Koslowski M.J. … Wehkamp J. (PLoS ONE 2009) 3 22 46 64
  5. Whole-grain consumption and transcription factor-7-like 2 ( TCF7L2) rs7903146: gene-diet interaction in modulating type 2 diabetes risk. (PMID: 19149908) Fisher E. … Schulze M.B. (Br. J. Nutr. 2009) 3 22 46 64

Products for TCF7L2 Gene

Sources for TCF7L2 Gene

Content
Loading form....