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Aliases for TCF7L1 Gene

Aliases for TCF7L1 Gene

  • Transcription Factor 7 Like 1 2 3
  • Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box) 2 3 5
  • HMG Box Transcription Factor 3 3 4
  • TCF-3 3 4
  • TCF3 3 4

External Ids for TCF7L1 Gene

Previous HGNC Symbols for TCF7L1 Gene

  • TCF3

Previous GeneCards Identifiers for TCF7L1 Gene

  • GC00U990369
  • GC02P085318
  • GC02P085335
  • GC02P085272

Summaries for TCF7L1 Gene

Entrez Gene Summary for TCF7L1 Gene

  • This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]

GeneCards Summary for TCF7L1 Gene

TCF7L1 (Transcription Factor 7 Like 1) is a Protein Coding gene. Diseases associated with TCF7L1 include Glioblastoma Multiforme. Among its related pathways are Endometrial cancer and Pathways in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is TCF7L2.

UniProtKB/Swiss-Prot for TCF7L1 Gene

  • Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.

Gene Wiki entry for TCF7L1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF7L1 Gene

Genomics for TCF7L1 Gene

Regulatory Elements for TCF7L1 Gene

Enhancers for TCF7L1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TCF7L1 on UCSC Golden Path with GeneCards custom track

Promoters for TCF7L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCF7L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCF7L1 Gene

Chromosome:
2
Start:
85,133,410 bp from pter
End:
85,310,388 bp from pter
Size:
176,979 bases
Orientation:
Plus strand

Genomic View for TCF7L1 Gene

Genes around TCF7L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF7L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF7L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF7L1 Gene

Proteins for TCF7L1 Gene

  • Protein details for TCF7L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCS4-TF7L1_HUMAN
    Recommended name:
    Transcription factor 7-like 1
    Protein Accession:
    Q9HCS4
    Secondary Accessions:
    • Q53R97
    • Q6PD70
    • Q9NP00

    Protein attributes for TCF7L1 Gene

    Size:
    588 amino acids
    Molecular mass:
    62631 Da
    Quaternary structure:
    • Binds the armadillo repeat of CTNNB1 and forms a stable complex.

neXtProt entry for TCF7L1 Gene

Proteomics data for TCF7L1 Gene at MOPED

Post-translational modifications for TCF7L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCF7L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TCF7L1 (TCF3)

No data available for DME Specific Peptides for TCF7L1 Gene

Domains & Families for TCF7L1 Gene

Protein Domains for TCF7L1 Gene

Suggested Antigen Peptide Sequences for TCF7L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCS4

UniProtKB/Swiss-Prot:

TF7L1_HUMAN :
  • The putative Groucho interaction domain between the N-terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1.
  • Belongs to the TCF/LEF family.
Domain:
  • The putative Groucho interaction domain between the N-terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1.
  • Contains 1 HMG box DNA-binding domain.
Family:
  • Belongs to the TCF/LEF family.
genes like me logo Genes that share domains with TCF7L1: view

No data available for Gene Families for TCF7L1 Gene

Function for TCF7L1 Gene

Molecular function for TCF7L1 Gene

UniProtKB/Swiss-Prot Function:
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.

Gene Ontology (GO) - Molecular Function for TCF7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008013 beta-catenin binding IBA --
genes like me logo Genes that share ontologies with TCF7L1: view
genes like me logo Genes that share phenotypes with TCF7L1: view

Animal Models for TCF7L1 Gene

MGI Knock Outs for TCF7L1:

Animal Model Products

CRISPR Products

miRNA for TCF7L1 Gene

Targeted motifs for TCF7L1 Gene
HOMER Transcription Factor Regulatory Elements motif TCF7L1
  • Consensus sequence: ACATCAAAGG Submotif: canonical Cell Type: mES GEO ID: GSE11724

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for TCF7L1 Gene

Localization for TCF7L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF7L1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCF7L1 Gene COMPARTMENTS Subcellular localization image for TCF7L1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TCF7L1 Gene

Pathways & Interactions for TCF7L1 Gene

genes like me logo Genes that share pathways with TCF7L1: view

Gene Ontology (GO) - Biological Process for TCF7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 1741298
GO:0030111 regulation of Wnt signaling pathway NAS 1741298
GO:1904837 beta-catenin-TCF complex assembly TAS --
genes like me logo Genes that share ontologies with TCF7L1: view

No data available for SIGNOR curated interactions for TCF7L1 Gene

Drugs & Compounds for TCF7L1 Gene

No Compound Related Data Available

Transcripts for TCF7L1 Gene

Unigene Clusters for TCF7L1 Gene

Transcription factor 7-like 1 (T-cell specific, HMG-box):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCF7L1 Gene

No ASD Table

Relevant External Links for TCF7L1 Gene

GeneLoc Exon Structure for
TCF7L1
ECgene alternative splicing isoforms for
TCF7L1

Expression for TCF7L1 Gene

mRNA expression in normal human tissues for TCF7L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TCF7L1 Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCF7L1 Gene



SOURCE GeneReport for Unigene cluster for TCF7L1 Gene Hs.516297

mRNA Expression by UniProt/SwissProt for TCF7L1 Gene

Q9HCS4-TF7L1_HUMAN
Tissue specificity: Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.
genes like me logo Genes that share expression patterns with TCF7L1: view

Protein tissue co-expression partners for TCF7L1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for TCF7L1 Gene

Orthologs for TCF7L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF7L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TCF7L1 35
  • 89.56 (n)
  • 93.95 (a)
-- 36
  • 97 (a)
OneToMany
BT.44249 36
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TCF7L1 35
  • 92.73 (n)
  • 97.85 (a)
TCF7L1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcf7l1 35
  • 90.32 (n)
  • 96.95 (a)
Tcf7l1 16
Tcf7l1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TCF7L1 35
  • 99.37 (n)
  • 99.66 (a)
TCF7L1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcf7l1 35
  • 90.22 (n)
  • 96.78 (a)
oppossum
(Monodelphis domestica)
Mammalia TCF7L1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCF7L1 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCF7L1 35
  • 77.58 (n)
  • 83.9 (a)
TCF7L1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCF7L1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcf7l1 35
  • 70.99 (n)
  • 77.96 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397969 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
tcf7l1a 35
  • 70.05 (n)
  • 74.91 (a)
tcf7l1a 36
  • 75 (a)
OneToMany
tcf7l1b 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta pan 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pop-1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11069 36
  • 37 (a)
OneToMany
Species with no ortholog for TCF7L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCF7L1 Gene

ENSEMBL:
Gene Tree for TCF7L1 (if available)
TreeFam:
Gene Tree for TCF7L1 (if available)

Paralogs for TCF7L1 Gene

Paralogs for TCF7L1 Gene

(2) SIMAP similar genes for TCF7L1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TCF7L1: view

Variants for TCF7L1 Gene

Sequence variations from dbSNP and Humsavar for TCF7L1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035938 A breast cancer sample
rs11547160 - 85,309,292(-) CTGCC(C/T)AGAGG reference, missense
rs723465 -- 85,232,559(+) ATGAT(G/T)ATCTT intron-variant
rs1554109 -- 85,265,879(-) TATTT(G/T)ATTCT intron-variant
rs1560585 -- 85,162,582(+) CAAAC(C/T)TTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCF7L1 Gene

Variant ID Type Subtype PubMed ID
nsv834279 CNV Loss 17160897
nsv834281 CNV Loss 17160897
esv2720293 CNV Deletion 23290073
nsv874458 CNV Loss 21882294
nsv834282 CNV Gain 17160897
nsv2809 CNV Loss 18451855
esv26672 CNV Loss 19812545
esv2454284 CNV Deletion 19546169
esv2015068 CNV Deletion 18987734
esv3927 CNV Deletion 18987735
esv2720294 CNV Deletion 23290073
esv1680148 CNV Deletion 17803354
esv5667 CNV Loss 19470904
nsv521146 CNV Gain 19592680

Variation tolerance for TCF7L1 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.11; 92.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCF7L1 Gene

Human Gene Mutation Database (HGMD)
TCF7L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF7L1 Gene

Disorders for TCF7L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCF7L1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
glioblastoma multiforme
  • adult glioblastoma multiforme
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TCF7L1

Genetic Association Database (GAD)
TCF7L1
Human Genome Epidemiology (HuGE) Navigator
TCF7L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCF7L1
genes like me logo Genes that share disorders with TCF7L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCF7L1 Gene

Publications for TCF7L1 Gene

  1. Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down- regulation. (PMID: 11085512) Sagara N. … Katoh M. (Cancer Res. 2000) 2 3 4 23 67
  2. INTS6/DICE1 inhibits growth of human androgen-independent prostate cancer cells by altering the cell cycle profile and Wnt signaling. (PMID: 19906297) Filleur S. … Wieland I. (Cancer Cell Int. 2009) 3 23
  3. Identification of replicative senescence-associated genes in human umbilical vein endothelial cells by an annealing control primer system. (PMID: 18258400) Kim T.W. … Kim J.R. (Exp. Gerontol. 2008) 3 23
  4. Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium. (PMID: 9916915) Barker N. … Clevers H. (Am. J. Pathol. 1999) 3 23
  5. A gene family of HMG-box transcription factors with homology to TCF- 1. (PMID: 1741298) Castrop J. … Clevers H.C. (Nucleic Acids Res. 1992) 2 3

Products for TCF7L1 Gene

Sources for TCF7L1 Gene

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