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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TCF7L1 Gene

protein-coding GIFtS: 61
GCID: GC02P085272

transcription factor 7-like 1 (T-cell specific, HMG-box)

(Previous symbol: TCF3)

Explore 17 diseases affiliated with
TCF7L1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box)¹ ²
TCF3¹ ² ³
TCF-3² ³
HMG Box Transcription Factor 3² ³
Transcription Factor 7-Like 1²

External Ids:	HGNC: 11640¹	Entrez Gene: 83439²	Ensembl: ENSG00000152284⁷	OMIM: 604652⁵	UniProtKB: Q9HCS4³

Export aliases for TCF7L1 gene to outside databases

Previous GC identifers: GC00U990369 GC02P085318 GC02P085335

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCF7L1:

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These

transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the

transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding

domain and participates in the regulation of cell cycle genes and cellular senescence. (provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: TF7L1_HUMAN, Q9HCS4

Function: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and

as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of

keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates

NQO1, leading to increased mitomycin c resistance

Gene Wiki entry for TCF7L1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TCF7L1 gene promoter:
GATA-3 RREB-1 Olf-1 STAT5A AP-2gamma c-Myb STAT3 AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TCF7L1 promoter sequence

Search SABiosciences Chromatin IP Primers for TCF7L1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF7L1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2

TCF7L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCF7L1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P085272: view genomic region (about GC identifiers)

Start:	85,360,533 bp from pter	End:	85,537,511 bp from pter
Size:	176,979 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TF7L1_HUMAN, Q9HCS4 (See protein sequence)

Recommended Name: Transcription factor 7-like 1

Size: 588 amino acids; 62631 Da

Subunit: Binds the armadillo repeat of CTNNB1 and forms a stable complex (By similarity)

Subcellular location: Nucleus

Secondary accessions: Q53R97 Q6PD70 Q9NP00

Explore the universe of human proteins at neXtProt for TCF7L1: NX_Q9HCS4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HCS4

TCF7L1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_112573.1

ENSEMBL proteins:

ENSP00000282111 ENSP00000388984

Human Recombinant Protein Products for TCF7L1:

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	Uscn Proteins for TCF7L1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	11085512
GO:0005667	transcription factor complex	IBA	--

TCF7L1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TCF7L1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TCF7L1 for domains About GeneDecksing

3 InterPro domains/families:

IPR009071 HMG_superfamily

IPR024940 TCF/LEF

IPR013558 CTNNB1-bd_N

Graphical View of Domain Structure for InterPro Entry Q9HCS4

ProtoNet protein and cluster: Q9HCS4

1 Blocks protein family: IPB013558 CTNNB1 binding

UniProtKB/Swiss-Prot: TF7L1_HUMAN, Q9HCS4

Domain: The putative Groucho interaction domain between the N-terminal CTNNB1 binding domain and the HMG-box is

necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1 (By similarity)

Similarity: Belongs to the TCF/LEF family

Similarity: Contains 1 HMG box DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TF7L1_HUMAN, Q9HCS4

Function: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and

as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of

keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates

NQO1, leading to increased mitomycin c resistance

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	NAS	11085512
GO:0003682	chromatin binding	IBA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	NAS	11085512
GO:0005515	protein binding	--	--
GO:0008013	beta-catenin binding	IBA	--

TCF7L1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for TCF7L1:

Increased cell number in S

12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Tcf7l1):

cardiovascular system	craniofacial	digestive/alimentary	embryogenesis	growth/size
homeostasis/metabolism	limbs/digits/tail	mortality/aging	nervous system	no phenotypic analysis
pigmentation	vision/eye

TCF7L1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Tcf7l1^tm2Efu for TCF7L1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TCF7L1

miRNA Products:		OriGene 3'-UTR Clone: TCF7L1 Browse MicroRNA Expression Plasmids
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		hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-759 hsa-miR-372 hsa-miR-93 hsa-miR-302b

		SwitchGear 3'UTR luciferase reporter plasmid: TCF7L1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF7L1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Endometrial cancer

Endometrial cancer	1.00	Colorectal cancer	0.42
Signal transduction_PTEN pathway	0.45	Acute myeloid leukemia	0.39
Signal transduction PTEN pathway	0.45

Wnt Signaling Pathway

	Wnt Signaling Pathway and Pluripotency	0.55			Wnt signaling pathway	0.30
	Wnt Signaling Pathway	0.33

Cell adhesion Tight junctions

Cell adhesion Tight junctions

1.00

Cell adhesion_Tight junctions

0.99

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

1.00

Arrhythmogenic right ventricular cardiomyopathy

0.99

Basal cell carcinoma

Basal cell carcinoma

1.00

Melanogenesis

0.32

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for TCF7L1

	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion Tight junctions
	Signal transduction PTEN pathway

1 R&D Systems Pathway for TCF7L1

Wnt Signaling Pathway

1 Cell Signaling Technology (CST) Pathway for TCF7L1

Wnt / Hedgehog / Notch

3 GeneGo (Thomson Reuters) Pathways for TCF7L1

	Cytoskeleton remodeling Integrin outside-in signaling
	Signal transduction PTEN pathway
	Cell adhesion Tight junctions

4 BioSystems Pathways for TCF7L1

	Wnt Signaling Pathway and Pluripotency
	Neural Crest Differentiation
	Arrhythmogenic right ventricular cardiomyopathy
	Regulation of Wnt-mediated beta catenin signaling and target gene transcription

5/11 Kegg Pathways (Kegg details for TCF7L1) (see all 11):

	Wnt signaling pathway
	Adherens junction
	Melanogenesis
	Pathways in cancer
	Colorectal cancer

TCF7L1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TCF7L1

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/25 Interacting proteins for TCF7L1 (Q9HCS4³ ENSP00000282111⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 25)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTNNB1	P35222³, ENSP00000344456⁴	I2D: score=2 STRING: ENSP00000344456
DAZAP2	Q15038³, ENSP00000404968⁴	I2D: score=1 STRING: ENSP00000404968
ID3	Q02535³	I2D: score=1
TRAF1	Q13077³	I2D: score=1
AXIN2	ENSP00000302625⁴	STRING: ENSP00000302625

About this table

Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006325	chromatin organization	NAS	11085512
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	NAS	11085512
GO:0006357	regulation of transcription from RNA polymerase II promoter	IBA	--
GO:0007420	brain development	IBA	--

TCF7L1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TCF7L1
Search CenterWatch for drugs/clinical trials and news about TCF7L1 / TF7L1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TCF7L1 gene:

NM_031283.2

Unigene Cluster for TCF7L1:

Transcription factor 7-like 1 (T-cell specific, HMG-box)

Hs.516297 [show with all ESTs]

Unigene Representative Sequence: NM_031283

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000282111(uc002soy.3) ENST00000494519 ENST00000442813 ENST00000490744

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		8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate TCF7L1 (see all 59):
		hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-759 hsa-miR-372 hsa-miR-93 hsa-miR-302b

		SwitchGear 3'UTR luciferase reporter plasmid: TCF7L1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCF7L1

Additional cDNA sequence:

AB031046.1 BC058894.1 U15553.1

3 DOTS entries:

DT.414325 DT.120936425 DT.100019854

24/92 AceView cDNA sequences (see all 92):

BF593480 AI360140 BQ028737 AB031046 AI400422 BX105465 AA320925 AA488717

BU543840 R54924 NM_031283 AI088403 AA781057 AA705286 AI381557 AI199181

BQ219329 AA889364 AI884941 BQ448221 H97902 T84207 BF569450 AI886964

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TCF7L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTCTTCTGT

About this image

TCF7L1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TCF7L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCF7L1

SOURCE GeneReport for Unigene cluster: Hs.516297

UniProtKB/Swiss-Prot: TF7L1_HUMAN, Q9HCS4

Tissue specificity: Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium

SABiosciences Expression via Pathway-Focused PCR Arrays including TCF7L1:

WNT Signaling Targets in human mouse rat

WNT Signaling Pathway in human mouse rat

Stem Cell Signaling in human mouse rat

Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCF7L1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF7L1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TCF7L1 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	--	--	77(a)	1 ↔ 1	GL343238.1(74904-89319)
African clawed frog (Xenopus laevis)	Amphibia	LOC397969²	transcription factor XTCF-3c	78.05(n)		AF287149.1
zebrafish (Danio rerio)	Actinopterygii	AY221031.1²	--	78.17(n)		30556 AY221031.1
fruit fly (Drosophila melanogaster)	Insecta	pan⁶	pangolin	12(a)	1 → many	4(89956-134454)
worm (Caenorhabditis elegans)	Secernentea	pop-1⁶	Protein pop-1	23(a)	1 → many	I(2823470-2830295)

ENSEMBL Gene Tree for TCF7L1 (if available)
TreeFam Gene Tree for TCF7L1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TCF7L1 gene

LEF1² TCF7² TCF7L2²

2 SIMAP similar genes for TCF7L1 using alignment to 3 protein entries: TF7L1_HUMAN (see all proteins):

TCF7L2 LEF1

TCF7L1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3810822^1,2	C,F,H	--	85358985(+)	`AGAAAC/GCAGAA`	1	--	us2k¹		14		EA NS NA WA CSA	2448
rs183516859^1,2		--	85358988(+)	`AACCAG/TAAAAC`	1	--	us2k¹		0	--	--	--	--
rs188952313^1,2		--	85359027(+)	`AATAGC/TCATTG`	1	--	us2k¹		0	--	--	--	--
rs193102580^1,2		--	85359074(+)	`AGAAAA/TAAATG`	1	--	us2k¹		0	--	--	--	--
rs140760105^1,2	C	--	85359087(+)	`TATAA-/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs184289800^1,2		--	85359326(+)	`TCTGAG/TGCTTT`	1	--	us2k¹		0	--	--	--	--
rs186748810^1,2		--	85359436(+)	`TTCCAA/GGCTGT`	1	--	us2k¹		0	--	--	--	--
rs191600100^1,2		--	85359549(+)	`TCATTA/GTAACA`	1	--	us2k¹		0	--	--	--	--
rs201696737^1,2		--	85359568(+)	`TTATT-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs930190^1,2	C	--	85359576(-)	`AAAAAA/TTTTTT`	1	--	us2k¹ trp³		4		WA NA EA	360

HapMap Linkage Disequilibrium report for TCF7L1 (85360533 - 85537511 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for TCF7L1
1 CNV: 97907
7 Indels: 26751 40341 61786 46056 74098 42364 50580
Human Gene Mutation Database (HGMD): TCF7L1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TCF7L1 for disorders           About GeneDecksing

OMIM gene information: 604652    OMIM disorders: --

17 diseases for TCF7L1:    About MalaCards

basal cell carcinoma acute myeloid leukemia myeloid leukemia bipolar disorder

endometrial cancer osteoporosis osteoarthritis thyroid cancer

gastric cancer colorectal cancer thyroiditis leukemia

prostate cancer glioblastoma prostatitis carcinoma

neuronitis

Human Genome Epidemiology (HuGE) Navigator: TCF7L1 (3 documents)

Export disorders for TCF7L1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TCF7L1 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with TCF7L1)

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Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down- regulation. (PubMed id 11085512)^{1, 2, 3, 9} Sagara N. and Katoh M. (2000)
A gene family of HMG-box transcription factors with homology to TCF- 1. (PubMed id 1741298)^{1, 2, 3} Castrop J.... Clevers H.C. (1992)
Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium. (PubMed id 9916915)^{1, 2, 9} Barker N.... Clevers H. (1999)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
INTS6/DICE1 inhibits growth of human androgen-indepen dent prostate cancer cells by altering the cell cycle profile and Wnt signaling . (PubMed id 19906297)^{1, 9} Filleur S....Wieland I. (2009)
Identification of replicative senescence-associated genes in human umbilical vein endothelial cells by an annealing control primer system. (PubMed id 18258400)^{1, 9} Kim T.W....Kim J.R. (2008)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
TCF-3, 4 protein expression correlates with beta-cate nin expression in MSS and MSI-H colorectal cancer from HNPCC patients but not i n sporadic colorectal cancers. (PubMed id 20532534)¹ Balaz P....Schackert H.K. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 83439	HGNC: 11640	AceView: TCF7L1	Ensembl:ENSG00000152284	euGenes: HUgn83439
ECgene: TCF7L1	Kegg: 83439	H-InvDB: TCF7L1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TCF7L1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TCF7L1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TCF7L1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TCF7L1 gene:
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GeneCards and IP:
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TCF7L1 Gene

transcription factor 7-like 1 (T-cell specific, HMG-box)

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TCF7L1 Gene

transcription factor 7-like 1 (T-cell specific, HMG-box)

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