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Aliases for TCF7L1 Gene

Aliases for TCF7L1 Gene

  • Transcription Factor 7 Like 1 2 3 5
  • Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box) 2 3
  • HMG Box Transcription Factor 3 3 4
  • TCF-3 3 4
  • TCF3 3 4
  • Transcription Factor 7-Like 1 3

External Ids for TCF7L1 Gene

Previous HGNC Symbols for TCF7L1 Gene

  • TCF3

Previous GeneCards Identifiers for TCF7L1 Gene

  • GC00U990369
  • GC02P085318
  • GC02P085335
  • GC02P085272

Summaries for TCF7L1 Gene

Entrez Gene Summary for TCF7L1 Gene

  • This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]

GeneCards Summary for TCF7L1 Gene

TCF7L1 (Transcription Factor 7 Like 1) is a Protein Coding gene. Diseases associated with TCF7L1 include Anogenital Venereal Wart. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and Endometrial cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is TCF7L2.

UniProtKB/Swiss-Prot for TCF7L1 Gene

  • Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.

Gene Wiki entry for TCF7L1 Gene

Additional gene information for TCF7L1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF7L1 Gene

Genomics for TCF7L1 Gene

Regulatory Elements for TCF7L1 Gene

Enhancers for TCF7L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H085275 1.5 VISTA FANTOM5 Ensembl ENCODE dbSUPER 25.2 +144.1 144090 3 RNF2 POLR2A RCOR1 TCF7L1 RNU6-674P RPS2P17 TRABD2A SH2D6 LOC100996506 ATOH8 TMEM150A TMSB10 ENSG00000230299
GH02H085254 1.6 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +123.8 123814 6 NFIB JUN CEBPG ZNF121 E2F1 ZFHX2 CTBP1 GATA3 POLR2A RCOR1 TCF7L1 RNU6-674P ATOH8 ENSG00000230299 LOC105374839
GH02H085536 1.7 FANTOM5 ENCODE dbSUPER 20.4 +406.4 406351 6 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SNORD94 USP39 KDM3A TCF7L1 C2orf68 VAMP8 GGCX SH2D6 CAPG RN7SL251P
GH02H084904 1.4 ENCODE dbSUPER 21.1 -226.4 -226410 5 HDGF FOXA2 MLX ARID4B SIN3A YBX1 DMAP1 SLC30A9 ZNF302 ZNF143 USP39 TCF7L1 ELMOD3 C2orf68 LOC100996506 TRABD2A VAMP8 TMSB10
GH02H084918 2 FANTOM5 Ensembl ENCODE dbSUPER 12 -213.6 -213569 3 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 FOS SP3 MAT2A TCF7L1 ELMOD3 KCMF1 TMSB10 RPS2P17 LOC105374838
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCF7L1 on UCSC Golden Path with GeneCards custom track

Promoters for TCF7L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119519 490 2601 SIN3A GLI4 ZNF2 ZBTB7B ETS1 ZNF121 GLIS2 KLF7 ZNF202 SP3

Genomic Location for TCF7L1 Gene

Chromosome:
2
Start:
85,133,410 bp from pter
End:
85,310,388 bp from pter
Size:
176,979 bases
Orientation:
Plus strand

Genomic View for TCF7L1 Gene

Genes around TCF7L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF7L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF7L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF7L1 Gene

Proteins for TCF7L1 Gene

  • Protein details for TCF7L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCS4-TF7L1_HUMAN
    Recommended name:
    Transcription factor 7-like 1
    Protein Accession:
    Q9HCS4
    Secondary Accessions:
    • Q53R97
    • Q6PD70
    • Q9NP00

    Protein attributes for TCF7L1 Gene

    Size:
    588 amino acids
    Molecular mass:
    62631 Da
    Quaternary structure:
    • Binds the armadillo repeat of CTNNB1 and forms a stable complex.

neXtProt entry for TCF7L1 Gene

Post-translational modifications for TCF7L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCF7L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TCF7L1 (TCF3)
  • Abcam antibodies for TCF7L1

No data available for DME Specific Peptides for TCF7L1 Gene

Domains & Families for TCF7L1 Gene

Gene Families for TCF7L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TCF7L1 Gene

Suggested Antigen Peptide Sequences for TCF7L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCS4

UniProtKB/Swiss-Prot:

TF7L1_HUMAN :
  • The putative Groucho interaction domain between the N-terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1.
  • Belongs to the TCF/LEF family.
Domain:
  • The putative Groucho interaction domain between the N-terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1.
Family:
  • Belongs to the TCF/LEF family.
genes like me logo Genes that share domains with TCF7L1: view

Function for TCF7L1 Gene

Molecular function for TCF7L1 Gene

UniProtKB/Swiss-Prot Function:
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.

Phenotypes From GWAS Catalog for TCF7L1 Gene

Gene Ontology (GO) - Molecular Function for TCF7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 1741298
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 1741298
GO:0008013 beta-catenin binding IBA --
GO:0043565 sequence-specific DNA binding IBA --
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with TCF7L1: view
genes like me logo Genes that share phenotypes with TCF7L1: view

Animal Models for TCF7L1 Gene

MGI Knock Outs for TCF7L1:

Animal Model Products

CRISPR Products

miRNA for TCF7L1 Gene

Targeted motifs for TCF7L1 Gene
HOMER Transcription Factor Regulatory Elements motif TCF7L1
  • Consensus sequence: ACATCAAAGG Submotif: canonical Cell Type: mES GEO ID: GSE11724

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TCF7L1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for TCF7L1 Gene

Localization for TCF7L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF7L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCF7L1 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCF7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 1741298
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TCF7L1: view

Pathways & Interactions for TCF7L1 Gene

genes like me logo Genes that share pathways with TCF7L1: view

Gene Ontology (GO) - Biological Process for TCF7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization NAS 1741298
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 1741298
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with TCF7L1: view

No data available for SIGNOR curated interactions for TCF7L1 Gene

Drugs & Compounds for TCF7L1 Gene

No Compound Related Data Available

Transcripts for TCF7L1 Gene

Unigene Clusters for TCF7L1 Gene

Transcription factor 7-like 1 (T-cell specific, HMG-box):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TCF7L1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TCF7L1 Gene

No ASD Table

Relevant External Links for TCF7L1 Gene

GeneLoc Exon Structure for
TCF7L1
ECgene alternative splicing isoforms for
TCF7L1

Expression for TCF7L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCF7L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TCF7L1 Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCF7L1 Gene



Protein tissue co-expression partners for TCF7L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCF7L1 Gene:

TCF7L1

SOURCE GeneReport for Unigene cluster for TCF7L1 Gene:

Hs.516297

mRNA Expression by UniProt/SwissProt for TCF7L1 Gene:

Q9HCS4-TF7L1_HUMAN
Tissue specificity: Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.

Evidence on tissue expression from TISSUES for TCF7L1 Gene

  • Lung(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with TCF7L1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF7L1 Gene

Orthologs for TCF7L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF7L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF7L1 33 34
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 97 (a)
OneToMany
TCF7L1 33
  • 89.56 (n)
BT.44249 34
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TCF7L1 33 34
  • 92.73 (n)
mouse
(Mus musculus)
Mammalia Tcf7l1 33 16 34
  • 90.32 (n)
rat
(Rattus norvegicus)
Mammalia Tcf7l1 33
  • 90.22 (n)
oppossum
(Monodelphis domestica)
Mammalia TCF7L1 34
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCF7L1 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCF7L1 33 34
  • 77.58 (n)
lizard
(Anolis carolinensis)
Reptilia TCF7L1 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcf7l1 33
  • 70.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397969 33
zebrafish
(Danio rerio)
Actinopterygii tcf7l1b 34
  • 75 (a)
OneToMany
tcf7l1a 33 34
  • 70.05 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta pan 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pop-1 34
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11069 34
  • 37 (a)
OneToMany
Species where no ortholog for TCF7L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCF7L1 Gene

ENSEMBL:
Gene Tree for TCF7L1 (if available)
TreeFam:
Gene Tree for TCF7L1 (if available)

Paralogs for TCF7L1 Gene

Paralogs for TCF7L1 Gene

(2) SIMAP similar genes for TCF7L1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TCF7L1: view

Variants for TCF7L1 Gene

Sequence variations from dbSNP and Humsavar for TCF7L1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035938 A breast cancer sample
rs1000020369 -- 85,301,505(+) TTACC(A/C)ATTGT intron-variant
rs1000048452 -- 85,296,051(+) GGGAC(C/T)ATAGG intron-variant
rs1000057001 -- 85,285,733(+) CCCCC(C/G)AGTGC intron-variant
rs1000072745 -- 85,219,421(+) AAGAA(C/T)GCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCF7L1 Gene

Variant ID Type Subtype PubMed ID
dgv1944n106 CNV deletion 24896259
esv1680148 CNV deletion 17803354
esv2015068 CNV deletion 18987734
esv2454284 CNV deletion 19546169
esv26672 CNV loss 19812545
esv2720293 CNV deletion 23290073
esv2720294 CNV deletion 23290073
esv2843347 CNV deletion 24192839
esv3559722 CNV deletion 23714750
esv3559744 CNV deletion 23714750
esv3575266 CNV gain 25503493
esv3591529 CNV loss 21293372
esv3927 CNV loss 18987735
esv5667 CNV loss 19470904
nsv1072004 CNV deletion 25765185
nsv1152279 CNV deletion 26484159
nsv2809 CNV deletion 18451855
nsv521146 CNV gain 19592680
nsv582368 CNV loss 21841781
nsv834279 CNV loss 17160897
nsv834281 CNV loss 17160897
nsv834282 CNV gain 17160897
nsv956659 CNV deletion 24416366
nsv963630 CNV duplication 23825009

Variation tolerance for TCF7L1 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.11; 92.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCF7L1 Gene

Human Gene Mutation Database (HGMD)
TCF7L1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCF7L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF7L1 Gene

Disorders for TCF7L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCF7L1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
anogenital venereal wart
  • anogenital human papilloma virus infectious disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TCF7L1

Genetic Association Database (GAD)
TCF7L1
Human Genome Epidemiology (HuGE) Navigator
TCF7L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCF7L1
genes like me logo Genes that share disorders with TCF7L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCF7L1 Gene

Publications for TCF7L1 Gene

  1. Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation. (PMID: 11085512) Sagara N … Katoh M (Cancer research 2000) 2 3 4 22 60
  2. Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium. (PMID: 9916915) Barker N … Clevers H (The American journal of pathology 1999) 3 4 22 60
  3. A gene family of HMG-box transcription factors with homology to TCF-1. (PMID: 1741298) Castrop J … Clevers H (Nucleic acids research 1992) 2 3 4 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. INTS6/DICE1 inhibits growth of human androgen-independent prostate cancer cells by altering the cell cycle profile and Wnt signaling. (PMID: 19906297) Filleur S … Wieland I (Cancer cell international 2009) 3 22 60

Products for TCF7L1 Gene

Sources for TCF7L1 Gene

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