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Aliases for TCF7L1 Gene

Aliases for TCF7L1 Gene

  • Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box) 2 3
  • HMG Box Transcription Factor 3 3 4
  • TCF-3 3 4
  • TCF3 3 4
  • Transcription Factor 7-Like 1 3

External Ids for TCF7L1 Gene

Previous Symbols for TCF7L1 Gene

  • TCF3

Summaries for TCF7L1 Gene

Entrez Gene Summary for TCF7L1 Gene

  • This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]

GeneCards Summary for TCF7L1 Gene

TCF7L1 (Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is TCF7L2.

UniProtKB/Swiss-Prot for TCF7L1 Gene

  • Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.

Gene Wiki entry for TCF7L1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF7L1 Gene

Genomics for TCF7L1 Gene

Genomic Location for TCF7L1 Gene

Start:
85,133,410 bp from pter
End:
85,310,388 bp from pter
Size:
176,979 bases
Orientation:
Plus strand

Genomic View for TCF7L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCF7L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF7L1 Gene

Regulatory Elements for TCF7L1 Gene

Proteins for TCF7L1 Gene

  • Protein details for TCF7L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCS4-TF7L1_HUMAN
    Recommended name:
    Transcription factor 7-like 1
    Protein Accession:
    Q9HCS4
    Secondary Accessions:
    • Q53R97
    • Q6PD70
    • Q9NP00

    Protein attributes for TCF7L1 Gene

    Size:
    588 amino acids
    Molecular mass:
    62631 Da
    Quaternary structure:
    • Binds the armadillo repeat of CTNNB1 and forms a stable complex.

neXtProt entry for TCF7L1 Gene

Proteomics data for TCF7L1 Gene at MOPED

Post-translational modifications for TCF7L1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys348 and Lys394

Other Protein References for TCF7L1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TCF7L1 Gene

Domains for TCF7L1 Gene

Protein Domains for TCF7L1 Gene

Suggested Antigen Peptide Sequences for TCF7L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCS4

UniProtKB/Swiss-Prot:

TF7L1_HUMAN
Domain:
  • The putative Groucho interaction domain between the N-terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1.:
    • Q9HCS4
  • Contains 1 HMG box DNA-binding domain.:
    • Q9HCS4
Family:
  • Belongs to the TCF/LEF family.:
    • Q9HCS4
genes like me logo Genes that share domains with TCF7L1: view

No data available for Gene Families for TCF7L1 Gene

Function for TCF7L1 Gene

Molecular function for TCF7L1 Gene

UniProtKB/Swiss-Prot Function: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.

Gene Ontology (GO) - Molecular Function for TCF7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 11085512
GO:0003682 chromatin binding IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 11085512
GO:0005515 protein binding --
GO:0008013 beta-catenin binding IBA --
genes like me logo Genes that share ontologies with TCF7L1: view
genes like me logo Genes that share phenotypes with TCF7L1: view

Animal Models for TCF7L1 Gene

MGI Knock Outs for TCF7L1:

miRNA for TCF7L1 Gene

Targeting motifs for TCF7L1 Gene
HOMER Transcription Factor Regulatory Elements motif TCF7L1
  • Consensus sequence: ACATCAAAGG Submotif: canonical Cell Type: mES GeoId: GSE11724

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for TCF7L1 Gene

Localization for TCF7L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF7L1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCF7L1 Gene COMPARTMENTS Subcellular localization image for TCF7L1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TCF7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 11085512
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IBA --
genes like me logo Genes that share ontologies with TCF7L1: view

Pathways for TCF7L1 Gene

genes like me logo Genes that share pathways with TCF7L1: view

Gene Ontology (GO) - Biological Process for TCF7L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization NAS 11085512
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 11085512
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0007420 brain development IBA --
genes like me logo Genes that share ontologies with TCF7L1: view

Transcripts for TCF7L1 Gene

mRNA/cDNA for TCF7L1 Gene

Unigene Clusters for TCF7L1 Gene

Transcription factor 7-like 1 (T-cell specific, HMG-box):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCF7L1 Gene

No ASD Table

Relevant External Links for TCF7L1 Gene

GeneLoc Exon Structure for
TCF7L1
ECgene alternative splicing isoforms for
TCF7L1

Expression for TCF7L1 Gene

mRNA expression in normal human tissues for TCF7L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TCF7L1 Gene

SOURCE GeneReport for Unigene cluster for TCF7L1 Gene Hs.516297

mRNA Expression by UniProt/SwissProt for TCF7L1 Gene

Q9HCS4-TF7L1_HUMAN
Tissue specificity: Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.
genes like me logo Genes that share expressions with TCF7L1: view

No data available for mRNA differential expression in normal tissues for TCF7L1 Gene

Orthologs for TCF7L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF7L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF7L1 35
  • 99.37 (n)
  • 99.66 (a)
TCF7L1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 97 (a)
OneToMany
BT.44249 36
  • 88 (a)
OneToMany
TCF7L1 35
  • 89.56 (n)
  • 93.95 (a)
dog
(Canis familiaris)
Mammalia TCF7L1 35
  • 92.73 (n)
  • 97.85 (a)
TCF7L1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcf7l1 35
  • 90.32 (n)
  • 96.95 (a)
Tcf7l1 16
Tcf7l1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCF7L1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCF7L1 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcf7l1 35
  • 90.22 (n)
  • 96.78 (a)
chicken
(Gallus gallus)
Aves TCF7L1 35
  • 77.58 (n)
  • 83.9 (a)
TCF7L1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCF7L1 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397969 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tcf7l1 35
  • 70.99 (n)
  • 77.96 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
tcf7l1a 35
  • 70.05 (n)
  • 74.91 (a)
tcf7l1a 36
  • 75 (a)
OneToMany
tcf7l1b 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta pan 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pop-1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11069 36
  • 37 (a)
OneToMany
Species with no ortholog for TCF7L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCF7L1 Gene

ENSEMBL:
Gene Tree for TCF7L1 (if available)
TreeFam:
Gene Tree for TCF7L1 (if available)

Paralogs for TCF7L1 Gene

Paralogs for TCF7L1 Gene

Selected SIMAP similar genes for TCF7L1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TCF7L1: view

Variants for TCF7L1 Gene

Sequence variations from dbSNP and Humsavar for TCF7L1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1659 -- 85,187,730(-) TACTA(C/T)ATAGC intron-variant
rs9248 -- 85,310,189(-) GGGGC(C/T)GGTCC utr-variant-3-prime
rs723465 -- 85,232,559(+) ATGAT(G/T)ATCTT intron-variant
rs747078 -- 85,195,870(-) CTTTT(G/T)ATGGT intron-variant
rs753814 -- 85,195,299(+) GTTAA(C/T)GTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCF7L1 Gene

Variant ID Type Subtype PubMed ID
nsv834279 CNV Loss 17160897
nsv834281 CNV Loss 17160897
esv2720293 CNV Deletion 23290073
nsv874458 CNV Loss 21882294
nsv834282 CNV Gain 17160897
nsv2809 CNV Loss 18451855
esv26672 CNV Loss 19812545
esv2454284 CNV Deletion 19546169
esv2015068 CNV Deletion 18987734
esv3927 CNV Deletion 18987735
esv2720294 CNV Deletion 23290073
esv1680148 CNV Deletion 17803354
esv5667 CNV Loss 19470904
nsv521146 CNV Gain 19592680

Relevant External Links for TCF7L1 Gene

HapMap Linkage Disequilibrium report
TCF7L1
Human Gene Mutation Database (HGMD)
TCF7L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF7L1 Gene

Disorders for TCF7L1 Gene

Relevant External Links for TCF7L1

Genetic Association Database (GAD)
TCF7L1
Human Genome Epidemiology (HuGE) Navigator
TCF7L1
genes like me logo Genes that share disorders with TCF7L1: view

No data available for UniProtKB/Swiss-Prot for TCF7L1 Gene

Publications for TCF7L1 Gene

  1. Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down- regulation. (PMID: 11085512) Sagara N. … Katoh M. (Cancer Res. 2000) 2 3 4 23
  2. A gene family of HMG-box transcription factors with homology to TCF- 1. (PMID: 1741298) Castrop J. … Clevers H.C. (Nucleic Acids Res. 1992) 2 3 4
  3. Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium. (PMID: 9916915) Barker N. … Clevers H. (Am. J. Pathol. 1999) 3 4 23
  4. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. (PMID: 19308021) Ollila H.M. … Paunio T. (Mol. Psychiatry 2009) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TCF7L1 Gene

Sources for TCF7L1 Gene

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