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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCF7 Gene

protein-coding   GIFtS: 66
GCID: GC05P133478

Transcription Factor 7 (T-Cell Specific, HMG-Box)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcription Factor 7 (T-Cell Specific, HMG-Box)1 2     TCF-73
TCF-12 3     TCF13
T-Cell-Specific Transcription Factor 12 3     T-Cell Factor 13
Transcription Factor 72     

External Ids:    HGNC: 116391   Entrez Gene: 69322   Ensembl: ENSG000000810597   OMIM: 1899085   UniProtKB: P364023   

Export aliases for TCF7 gene to outside databases

Previous GC identifers: GC05P133100 GC05P133965 GC05P133481 GC05P133526 GC05P128635


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCF7 Gene:
The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte
differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer
element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback
mechanism. Several transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Oct 2011)

GeneCards Summary for TCF7 Gene: 
TCF7 (transcription factor 7 (T-cell specific, HMG-box)) is a protein-coding gene. Diseases associated with TCF7 include peripheral t-cell lymphoma, and venous thromboembolism, and among its related super-pathways are Endometrial cancer and Hypertrophic cardiomyopathy (HCM). GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TCF7L1.

UniProtKB/Swiss-Prot: TCF7_HUMAN, P36402
Function: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of
CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this
role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene.
May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4
repress transactivation mediated by TCF7 and CTNNB1

Gene Wiki entry for TCF7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCF7 gene promoter:
         HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TCF7 promoter sequence
   Search SABiosciences Chromatin IP Primers for TCF7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31

TCF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCF7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P133478:  view genomic region     (about GC identifiers)

Start:
133,450,402 bp from pter      End:
133,487,556 bp from pter
Size:
37,155 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCF7_HUMAN, P36402 (See protein sequence)
Recommended Name: Transcription factor 7  
Size: 384 amino acids; 41642 Da
Subunit: Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with AES, TLE1, TLE2, TLE3 and
TLE4
Subcellular location: Nucleus
Sequence caution: Sequence=CAA87441.1; Type=Erroneous translation; Note=Wrong choice of frame;
Secondary accessions: B3KSH3 Q86WR9 Q9UKI4
Alternative promoter usage, Alternative splicing: 16 isoforms:  P36402-1   P36402-2   P36402-3   P36402-4   P36402-9   P36402-10   P36402-11   P36402-12   
P36402-13   P36402-14   P36402-15   P36402-16   P36402-5   P36402-6   P36402-7   P36402-8   
(Produced by alternative splicing of isoform 4S)

Explore the universe of human proteins at neXtProt for TCF7: NX_P36402

Explore proteomics data for TCF7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P36402

  • TCF7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCF7 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001128323.2  NP_003193.2  NP_963963.1  NP_963965.1  NP_998813.1  

    ENSEMBL proteins: 
     ENSP00000340347   ENSP00000378472   ENSP00000430617   ENSP00000429946   ENSP00000427782  
     ENSP00000427870   ENSP00000367822   ENSP00000429547   ENSP00000430179   ENSP00000378469  
     ENSP00000431095   ENSP00000427758   ENSP00000429817   ENSP00000429696   ENSP00000429178  
     ENSP00000427968   ENSP00000429935   ENSP00000326654   ENSP00000326540   ENSP00000367827  
     ENSP00000397946  

    Human Recombinant Protein Products for TCF7: 
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    Novus Biologicals TCF7 Proteins
    Novus Biologicals TCF7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TCF7 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18579517
    GO:0005667transcription factor complex IBA--

    TCF7 for ontologies           About GeneDecksing



    TCF7 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for TCF7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR027397 Catenin_binding_dom
     IPR009071 HMG_box_dom
     IPR024940 TCF/LEF
     IPR013558 CTNNB1-bd_N

    Graphical View of Domain Structure for InterPro Entry P36402

    ProtoNet protein and cluster: P36402

    1 Blocks protein domain: IPB013558 CTNNB1 binding

    UniProtKB/Swiss-Prot: TCF7_HUMAN, P36402
    Similarity: Belongs to the TCF/LEF family
    Similarity: Contains 1 HMG box DNA-binding domain


    TCF7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCF7_HUMAN, P36402
    Function: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of
    CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this
    role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene.
    May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4
    repress transactivation mediated by TCF7 and CTNNB1
    Induction: By TCF7L2 and CTNNB1

         Genatlas biochemistry entry for TCF7:
    transcription factor 7,T cell specific

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0005515protein binding IPI16442529
    GO:0008013beta-catenin binding IDA9488439
         
    TCF7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TCF7:
     Decreased Wnt reporter activit 

         15 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tcf7):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  embryogenesis 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     mortality/aging  nervous system  skeleton  tumorigenesis  vision/eye 

    TCF7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TCF7: Tcf7tm2Cle Tcf7tm1Cle

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TCF7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TCF7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCF7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TCF7 

    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate TCF7 (see all 48):
    hsa-miR-100* hsa-miR-3607-3p hsa-miR-631 hsa-miR-485-3p hsa-miR-30d hsa-miR-624 hsa-miR-3921 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidTCF7 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TCF7 About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Endometrial cancer
    Endometrial cancer0.45
    Colorectal cancer0.42
    Signal transduction PTEN pathway0.45
    Acute myeloid leukemia0.40
    2Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Arrhythmogenic right ventricular cardiomyopathy0.53
    3Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway0.40
    4Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency0.50
    Factors Promoting Cardiogenesis in Vertebrates0.50
    5Rho Family GTPases
    MAPK Signaling0.58
    ILK Signaling0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for TCF7
        Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Tight junctions
    Signal transduction PTEN pathway

    1 R&D Systems Pathway for TCF7
        Wnt Signaling Pathway

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCF7 (see all 9)
        MAPK Signaling
    ILK Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    GSK3 Signaling
    Prolactin Signaling

    1 Cell Signaling Technology (CST) Pathway for TCF7
        Wnt / Hedgehog / Notch

    3 GeneGo (Thomson Reuters) Pathways for TCF7
        Cytoskeleton remodeling Integrin outside-in signaling
    Signal transduction PTEN pathway
    Cell adhesion Tight junctions

    3 BioSystems Pathways for TCF7
        Wnt Signaling Pathway and Pluripotency
    Arrhythmogenic right ventricular cardiomyopathy
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    5/12         Kegg Pathways  (Kegg details for TCF7) (see all 12):
        Wnt signaling pathway
    Hippo signaling pathway
    Adherens junction
    Melanogenesis
    Pathways in cancer


    TCF7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for TCF7 (P364022, 3 ENSP000003403474) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCRP112742, 3, ENSP000003035074MINT-1779661 I2D: score=1 STRING: ENSP00000303507
    CTNNB1P352222, 3, ENSP000003444564MINT-7023938 MINT-1779680 I2D: score=2 STRING: ENSP00000344456
    SS18L1O751773, ENSP000003330124I2D: score=1 STRING: ENSP00000333012
    RUNX3Q137613, ENSP000003434774I2D: score=1 STRING: ENSP00000343477
    DAZAP2Q150383, ENSP000004049684I2D: score=1 STRING: ENSP00000404968
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006955immune response TAS1569101
    GO:0007420brain development IBA--

    TCF7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCF7

    Search CenterWatch for drugs/clinical trials and news about TCF7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCF7 gene (6 alternative transcripts): 
    NM_001134851.2  NM_003202.3  NM_201632.3  NM_201634.3  NM_213648.3  NM_001134852.1  

    Unigene Cluster for TCF7:

    Transcription factor 7 (T-cell specific, HMG-box)
    Hs.573153  [show with all ESTs]
    Unigene Representative Sequence: NM_001134851
    18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000342854 ENST00000395029(uc003kyt.3) ENST00000518887 ENST00000522653(uc003kyu.2)
    ENST00000517851 ENST00000521639 ENST00000522375 ENST00000378560(uc003kyv.3 uc003kyw.3 uc003kyy.3 uc003kyz.3 uc003kza.3)
    ENST00000520958 ENST00000518915 ENST00000395023(uc003kyx.3 uc003kzb.3 uc010jdu.3)
    ENST00000519447 ENST00000517741 ENST00000519165 ENST00000520652 ENST00000519037
    ENST00000521970 ENST00000517478
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    Additional mRNA sequence: 

    AK057580.1 AK093530.1 AK310591.1 AL832816.1 BC048769.1 BC072023.1 NR_033449.1 X59869.1 
    X59870.1 X59871.1 Z47361.1 Z47362.1 Z47363.1 Z47364.1 

    24 DOTS entries:

    DT.100028013  DT.100028014  DT.40280515  DT.100790464  DT.100790465  DT.100790462  DT.75131395  DT.100790463 
    DT.120861922  DT.91999036  DT.95129214  DT.120861862  DT.120861876  DT.100790461  DT.120861850  DT.91689593 
    DT.91970497  DT.92041293  DT.120861879  DT.120861918  DT.120861924  DT.95095927  DT.97844516  DT.95194636 

    24/138 AceView cDNA sequences (see all 138):

    BM741126 BM845721 NM_213648 BQ653991 NM_003202 BQ651010 BP431393 NM_201634 
    BM558017 BQ223073 CR592040 AA319339 AI805261 NM_201632 BM761617 BF912800 
    BM851321 AA311787 AL834166 BQ645119 AA309508 Z47363 BM844333 BQ650057 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for TCF7 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^
    SP1:        -           -     -     -     -           -     -     -                             -     -                 -     -     -     -                     
    SP2:                                -     -           -     -     -                             -     -                 -     -     -     -                     
    SP3:                                -     -           -     -     -                             -     -                 -     -     -     -                     
    SP4:                                -     -           -     -     -                             -     -                 -     -     -     -                     
    SP5:                                                                                            -     -                 -     -     -     -                     

    ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c
    SP1:              -                 -     -     -     -               
    SP2:              -                 -           -                     
    SP3:              -                 -     -                           
    SP4:              -                 -     -     -     -               
    SP5:              -                 -           -     -               


    ECgene alternative splicing isoforms for TCF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCF7 expression in normal human tissues (normalized intensities)      TCF7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TCF7 Expression
    About this image


    TCF7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 5 entries
             visceral organ   
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             Double Negative 2 Thymocytes Thymus
             Thymus
             Thymus   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocytes Zeugopod Epiphyseal End
             Membranous Facial Bones
             skeleton/cranium   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Cord Blood Pan-T Cells   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
             skeleton/cranium   

    See TCF7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCF7

    SOURCE GeneReport for Unigene cluster: Hs.573153

    UniProtKB/Swiss-Prot: TCF7_HUMAN, P36402
    Tissue specificity: Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells
    and in the basal epithelial cells of mammary gland epithelium

        SABiosciences Expression via Pathway-Focused PCR Arrays including TCF7: 
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TCF7 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcf71 , 5 transcription factor 7, T cell specific1, 5 91.08(n)1
    96.65(a)1
      11 (31.86 cM)5
    214141  NM_009331.31  NP_033357.11 
     522523715 
    chicken
    (Gallus gallus)
    Aves TCF71 transcription factor 7 (T-cell specific, HMG-box) 72.49(n)
    67.17(a)
      395229  NM_204547.1  NP_989878.1 
    lizard
    (Anolis carolinensis)
    Reptilia TCF76
    transcription factor 7 (T-cell specific, HMG-box)
    62(a)
    1 ↔ 1
    2(130679476-130809461)
    zebrafish
    (Danio rerio)
    Actinopterygii tcf76
    transcription factor 7 (T-cell specific, HMG-box)
    55(a)
    1 ↔ 1
    21(44001407-44022195)
    fruit fly
    (Drosophila melanogaster)
    Insecta pan3 heart development transcription factor 46(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea pop-16
    Protein pop-1
    19(a)
    1 → many
    I(2823468-2830293)


    ENSEMBL Gene Tree for TCF7 (if available)
    TreeFam Gene Tree for TCF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCF7 gene
    TCF7L12  LEF12  TCF7L22  
    6 SIMAP similar genes for TCF7 using alignment to 13 protein entries:     TCF7_HUMAN (see all proteins):
    DKFZp586H0919    TCF7L2    LEF1    CIC    SRY    soxB

    TCF7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/753 SNPs in TCF7 are shown (see all 753)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1502165951,2
    C--128645324(+) CCTAA-/CCCCCC 6 -- int10--------
    rs1379395321,2
    C--128649242(+) CATGA-/CTCAAGA 6 -- int10--------
    rs754017511,2
    C--128658606(+) AGGCC-/TGTGGT 6 -- int10--------
    rs1500889521,2
    C--128669314(+) CAAAC-/AAGAGTC 1 -- ds50010--------
    rs3728510571,2
    C--133457276(+) CTCCT-/A/AA  
            
    AAAAA
    6 -- int10--------
    rs600038701,2
    C--133464633(+) GGAGG-/TTCAGA 6 -- int10--------
    rs58715231,2
    C--133473402(+) AGGCC-/CATGCC 6 -- int10--------
    rs785845661,2
    C--133477102(+) CAGTG-/CCAAAT 6 -- int10--------
    rs2017634341,2
    C--133723318(+) CTCAC-/TGTTGTTG 1 -- us2k10--------
    rs1473244331,2
    C--133723511(+) CTGTCC/GCAGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TCF7 (133450402 - 133487556 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TCF7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678103CNV Deletion23128226
    nsv5011CNV Insertion18451855


    Human Gene Mutation Database (HGMD): TCF7
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TCF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 189908    OMIM disorders: --

    20/33 diseases for TCF7 (see all 33):    About MalaCards
    peripheral t-cell lymphoma    venous thromboembolism    idiopathic pulmonary fibrosis    thromboembolism
    kawasaki disease    pulmonary fibrosis    migraine    aplastic anemia
    basal cell carcinoma    thyroid cancer    colon cancer    colorectal cancer
    acute myeloid leukemia    encephalitis    acute lymphoblastic leukemia    gastric cancer
    lymphoblastic leukemia    chronic lymphocytic leukemia    insulin resistance    type 1 diabetes

    1 disease from the University of Copenhagen DISEASES database for TCF7:
    Diabetes mellitus

    TCF7 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for TCF7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 38.2 5 19749792 (2), 18983819 (2), 17893322 (1)
    colorectal cancer 11.6 2 9259402 (2)
    tumors 9.41 6 11326276 (1), 14633602 (1), 10679386 (1)
    gastric cancer 0 3 11085512 (1)
    lymphoma 0 2 12707037 (1)
    cancer 0 1 10679386 (1)

    Genetic Association Database (GAD): TCF7
    Human Genome Epidemiology (HuGE) Navigator: TCF7 (19 documents)

    Export disorders for TCF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCF7 gene, integrated from 9 sources (see all 122):
    (articles sorted by number of sources associating them with TCF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization. (PubMed id 1569101)1, 2, 9 van de Wetering M.... Clevers H. (1992)
    2. A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. (PubMed id 12765974)1, 4, 9 Noble J.A....Erlich H.A. (2003)
    3. Independent predictive roles of eotaxin Ala23Thr, par aoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on car diac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients. (PubMed id 20536507)1, 4 Wang Y....Chan J.C. (2010)
    4. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (2010)
    5. Association between polymorphisms in Wnt signaling pa thway genes and bone mineral density in postmenopausal Korean women. (PubMed id 20613673)1, 4 Lee D.Y....Kim J.G. (2010)
    6. Single nucleotide polymorphisms in inflammation-relat ed genes are associated with venous thromboembolism. (PubMed id 20603037)1, 4 Beckers M.M....Biesma D.H. (2010)
    7. Single nucleotide polymorphisms in the Wnt and BMP pa thways and colorectal cancer risk in a Spanish cohort. (PubMed id 20844743)1, 4 FernA!ndez-Rozadilla C....Ruiz-Ponte C. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Polymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay. (PubMed id 19028820)1, 4 Greisenegger S....Mannhalter C. (2009)
    10. A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. (PubMed id 19131662)1, 4 Wang X....Cook N.R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6932 HGNC: 11639 AceView: TCF7 Ensembl:ENSG00000081059 euGenes: HUgn6932
    ECgene: TCF7 Kegg: 6932 H-InvDB: TCF7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCF7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TCF7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCF7 gene:
    Search GeneIP for patents involving TCF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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