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Aliases for TCF7 Gene

Aliases for TCF7 Gene

  • Transcription Factor 7 (T-Cell Specific, HMG-Box) 2 3 5
  • T-Cell-Specific Transcription Factor 1 3 4
  • TCF-1 3 4
  • T-Cell Factor 1 4
  • TCF-7 4
  • TCF1 4

External Ids for TCF7 Gene

Previous GeneCards Identifiers for TCF7 Gene

  • GC05P133100
  • GC05P133965
  • GC05P133481
  • GC05P133526
  • GC05P133478
  • GC05P128635

Summaries for TCF7 Gene

Entrez Gene Summary for TCF7 Gene

  • The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TCF7 Gene

TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box)) is a Protein Coding gene. Diseases associated with TCF7 include cleidocranial dysplasia and colorectal cancer. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is TCF7L2.

UniProtKB/Swiss-Prot for TCF7 Gene

  • Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5-WWCAAAG-3) found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

Gene Wiki entry for TCF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF7 Gene

Genomics for TCF7 Gene

Regulatory Elements for TCF7 Gene

Promoters for TCF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCF7 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCF7 Gene

Chromosome:
5
Start:
134,114,703 bp from pter
End:
134,151,865 bp from pter
Size:
37,163 bases
Orientation:
Plus strand

Genomic View for TCF7 Gene

Genes around TCF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF7 Gene

Proteins for TCF7 Gene

  • Protein details for TCF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36402-TCF7_HUMAN
    Recommended name:
    Transcription factor 7
    Protein Accession:
    P36402
    Secondary Accessions:
    • B3KSH3
    • Q86WR9
    • Q9UKI4

    Protein attributes for TCF7 Gene

    Size:
    384 amino acids
    Molecular mass:
    41642 Da
    Quaternary structure:
    • Binds the armadillo repeat of CTNNB1 and forms a stable complex (PubMed:9488439 PubMed:9783587). Interacts with AES, TLE1, TLE2, TLE3 and TLE4 (PubMed:9783587, PubMed:11266540). Interacts with MLLT11 (PubMed:26079538).
    SequenceCaution:
    • Sequence=CAA87441.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

neXtProt entry for TCF7 Gene

Proteomics data for TCF7 Gene at MOPED

Post-translational modifications for TCF7 Gene

  • Ubiquitination at Lys 52, Lys 253, and Lys 294
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TCF7 (TCF7)

No data available for DME Specific Peptides for TCF7 Gene

Domains & Families for TCF7 Gene

Protein Domains for TCF7 Gene

Suggested Antigen Peptide Sequences for TCF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36402

UniProtKB/Swiss-Prot:

TCF7_HUMAN :
  • Contains 1 HMG box DNA-binding domain.
  • Belongs to the TCF/LEF family.
Domain:
  • Contains 1 HMG box DNA-binding domain.
Family:
  • Belongs to the TCF/LEF family.
genes like me logo Genes that share domains with TCF7: view

No data available for Gene Families for TCF7 Gene

Function for TCF7 Gene

Molecular function for TCF7 Gene

GENATLAS Biochemistry:
transcription factor 7,T cell specific
UniProtKB/Swiss-Prot Function:
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5-WWCAAAG-3) found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
UniProtKB/Swiss-Prot Induction:
By TCF7L2 and CTNNB1.

Gene Ontology (GO) - Molecular Function for TCF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0008013 beta-catenin binding IEA,IDA 9488439
genes like me logo Genes that share ontologies with TCF7: view
genes like me logo Genes that share phenotypes with TCF7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TCF7

miRNA for TCF7 Gene

miRTarBase miRNAs that target TCF7

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCF7 Gene

Localization for TCF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCF7 Gene COMPARTMENTS Subcellular localization image for TCF7 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TCF7 Gene

Pathways & Interactions for TCF7 Gene

genes like me logo Genes that share pathways with TCF7: view

SIGNOR curated interactions for TCF7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TCF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030538 embryonic genitalia morphogenesis IEA --
GO:0033153 T cell receptor V(D)J recombination IEA --
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with TCF7: view

Drugs & Compounds for TCF7 Gene

No Compound Related Data Available

Transcripts for TCF7 Gene

Unigene Clusters for TCF7 Gene

Transcription factor 7 (T-cell specific, HMG-box):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCF7 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - -
SP9: - -
SP10:
SP11: - - - -
SP12: - -
SP13: - - - -
SP14: - - - - - - -
SP15: -
SP16: -
SP17: - - -
SP18:

ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - -
SP7:
SP8:
SP9: -
SP10: - - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for TCF7 Gene

GeneLoc Exon Structure for
TCF7
ECgene alternative splicing isoforms for
TCF7

Expression for TCF7 Gene

mRNA expression in normal human tissues for TCF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCF7 Gene

This gene is overexpressed in Whole Blood (x13.3).

Protein differential expression in normal tissues from HIPED for TCF7 Gene

This gene is overexpressed in Serum (32.7), CD8 Tcells (14.2), CD4 Tcells (9.8), and Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCF7 Gene



SOURCE GeneReport for Unigene cluster for TCF7 Gene Hs.573153

mRNA Expression by UniProt/SwissProt for TCF7 Gene

P36402-TCF7_HUMAN
Tissue specificity: Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.
genes like me logo Genes that share expression patterns with TCF7: view

Protein tissue co-expression partners for TCF7 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TCF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF7 36
  • 97 (a)
OneToOne
TCF7 35
  • 99.73 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia TCF7 36
  • 87 (a)
OneToOne
TCF7 35
  • 91.41 (n)
  • 92.71 (a)
dog
(Canis familiaris)
Mammalia TCF7 35
  • 91.78 (n)
  • 95.28 (a)
TCF7 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcf7 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCF7 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCF7 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCF1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCF7 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tcf7 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pan 37
  • 46 (a)
pan 36
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pop-1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11069 36
  • 25 (a)
OneToMany
Species with no ortholog for TCF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TCF7 Gene

ENSEMBL:
Gene Tree for TCF7 (if available)
TreeFam:
Gene Tree for TCF7 (if available)

Paralogs for TCF7 Gene

Paralogs for TCF7 Gene

genes like me logo Genes that share paralogs with TCF7: view

Variants for TCF7 Gene

Sequence variations from dbSNP and Humsavar for TCF7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs30489 -- 134,145,776(-) TTGTC(C/T)ATTAC intron-variant, reference, missense, utr-variant-3-prime
rs30490 -- 134,129,949(-) GGGGT(C/G)GGGGA intron-variant
rs152402 -- 134,142,650(-) TCTAG(C/T)GTGGG intron-variant
rs244692 -- 134,116,844(+) ACTCT(C/T)CTCAG intron-variant
rs244693 -- 134,119,462(+) ACATA(A/C)CCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCF7 Gene

Variant ID Type Subtype PubMed ID
nsv5011 CNV Insertion 18451855
esv2678103 CNV Deletion 23128226

Variation tolerance for TCF7 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCF7 Gene

HapMap Linkage Disequilibrium report
TCF7
Human Gene Mutation Database (HGMD)
TCF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF7 Gene

Disorders for TCF7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TCF7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cleidocranial dysplasia
  • cleidocranial dysplasia, forme fruste, with brachydactyly
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search TCF7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCF7

Genetic Association Database (GAD)
TCF7
Human Genome Epidemiology (HuGE) Navigator
TCF7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCF7
genes like me logo Genes that share disorders with TCF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCF7 Gene

Publications for TCF7 Gene

  1. The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization. (PMID: 1569101) van de Wetering M. … Clevers H. (J. Biol. Chem. 1992) 3 4 23 67
  2. SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts. (PMID: 20128911) Lambertini E. … Piva R. (BMC Mol. Biol. 2010) 3 23
  3. Evidence for association of the TCF7 locus with type I diabetes. (PMID: 19956102) Erlich H.A. … Noble J.A. (Genes Immun. 2009) 3 23
  4. LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element. (PMID: 18579517) Hebenstreit D. … Li-Weber M. (J. Biol. Chem. 2008) 3 23
  5. Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. (PMID: 16424171) Willinger T. … Callan M.F. (J. Immunol. 2006) 3 23

Products for TCF7 Gene

Sources for TCF7 Gene

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