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TCF7 Gene

protein-coding   GIFtS: 68
GCID: GC05P133478

Transcription Factor 7 (T-Cell Specific, HMG-Box)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Factor 7 (T-Cell Specific, HMG-Box)1 2     TCF-73
TCF-12 3     TCF13
T-Cell-Specific Transcription Factor 12 3     T-Cell Factor 13
Transcription Factor 72     

External Ids:    HGNC: 116391   Entrez Gene: 69322   Ensembl: ENSG000000810597   OMIM: 1899085   UniProtKB: P364023   

Export aliases for TCF7 gene to outside databases

Previous GC identifers: GC05P133100 GC05P133965 GC05P133481 GC05P133526 GC05P128635


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCF7 Gene:
The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte
differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer
element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback
mechanism. Several transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Oct 2011)

GeneCards Summary for TCF7 Gene:
TCF7 (transcription factor 7 (T-cell specific, HMG-box)) is a protein-coding gene. Diseases associated with TCF7 include peripheral t-cell lymphoma, and venous thromboembolism. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is LEF1.

UniProtKB/Swiss-Prot: TCF7_HUMAN, P36402
Function: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of
CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this
role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene.
May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4
repress transactivation mediated by TCF7 and CTNNB1

Gene Wiki entry for TCF7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCF7 gene promoter:
         HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TCF7 promoter sequence
   Search Chromatin IP Primers for TCF7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31

TCF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCF7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P133478:  view genomic region     (about GC identifiers)

Start:
133,450,402 bp from pter      End:
133,487,556 bp from pter
Size:
37,155 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TCF7_HUMAN, P36402 (See protein sequence)
Recommended Name: Transcription factor 7  
Size: 384 amino acids; 41642 Da
Subunit: Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with AES, TLE1, TLE2, TLE3 and
TLE4
Sequence caution: Sequence=CAA87441.1; Type=Erroneous translation; Note=Wrong choice of frame;
Secondary accessions: B3KSH3 Q86WR9 Q9UKI4
Alternative promoter usage, Alternative splicing: 16 isoforms:  P36402-1   P36402-2   P36402-3   P36402-4   P36402-9   P36402-10   P36402-11   P36402-12   
P36402-13   P36402-14   P36402-15   P36402-16   P36402-5   P36402-6   P36402-7   P36402-8   
(Produced by alternative splicing of isoform 4S)

Explore the universe of human proteins at neXtProt for TCF7: NX_P36402

Explore proteomics data for TCF7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys52, Lys253, Lys271, Lys294, Lys317
  • Modification sites at PhosphoSitePlus

  • See TCF7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001128323.2  NP_003193.2  NP_963963.1  NP_963965.1  NP_998813.1  

    ENSEMBL proteins: 
     ENSP00000340347   ENSP00000378472   ENSP00000430617   ENSP00000429946   ENSP00000427782  
     ENSP00000427870   ENSP00000367822   ENSP00000429547   ENSP00000430179   ENSP00000378469  
     ENSP00000431095   ENSP00000427758   ENSP00000429817   ENSP00000429696   ENSP00000429178  
     ENSP00000427968   ENSP00000429935   ENSP00000326654   ENSP00000326540   ENSP00000367827  
     ENSP00000397946  
    Reactome Protein details: P36402

    TCF7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for TCF7
    OriGene Custom MassSpec
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    Novus Biologicals TCF7 Proteins
    Novus Biologicals TCF7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TCF7

    TCF7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TCF7
    R&D Systems Antibodies for TCF7 (TCF7/TCF1)
    Cell Signaling Technology (CST) Antibodies for TCF7 
    OriGene Antibodies for TCF7
    OriGene Custom Antibody Services for TCF7
    Novus Biologicals TCF7 Antibodies
    Abcam antibodies for TCF7
    Cloud-Clone Corp. Antibodies for TCF7
    ThermoFisher Antibody for TCF7
    LSBio Antibodies in human, mouse, rat for TCF7

    TCF7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TCF7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TCF7
    Cloud-Clone Corp. CLIAs for TCF7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR027397 Catenin_binding_dom
     IPR009071 HMG_box_dom
     IPR028785 Tcf7
     IPR024940 TCF/LEF
     IPR013558 CTNNB1-bd_N

    Graphical View of Domain Structure for InterPro Entry P36402

    ProtoNet protein and cluster: P36402

    1 Blocks protein domain: IPB013558 CTNNB1 binding

    UniProtKB/Swiss-Prot: TCF7_HUMAN, P36402
    Similarity: Belongs to the TCF/LEF family
    Similarity: Contains 1 HMG box DNA-binding domain


    TCF7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCF7_HUMAN, P36402
    Function: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of
    CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this
    role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene.
    May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4
    repress transactivation mediated by TCF7 and CTNNB1
    Induction: By TCF7L2 and CTNNB1

         Genatlas biochemistry entry for TCF7:
    transcription factor 7,T cell specific

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IBA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0005515protein binding IPI16442529
    GO:0008013beta-catenin binding IDA9488439
         
    TCF7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TCF7:
     Decreased Wnt reporter activit 

         14 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tcf7):
     behavior/neurological  cardiovascular system  digestive/alimentary  embryogenesis  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  mortality/aging 
     nervous system  skeleton  tumorigenesis  vision/eye 

    TCF7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TCF7: Tcf7tm2Cle Tcf7tm1Cle

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCF7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TCF7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCF7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TCF7

    miRNA
    Products:
        
    miRTarBase miRNAs that target TCF7:
    hsa-mir-215-5p (MIRT024837), hsa-mir-192-5p (MIRT026207)

    Block miRNA regulation of human, mouse, rat TCF7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TCF7 (see all 48):
    hsa-miR-100* hsa-miR-3607-3p hsa-miR-631 hsa-miR-485-3p hsa-miR-30d hsa-miR-624 hsa-miR-3921 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidTCF7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TCF7
    Predesigned siRNA for gene silencing in human, mouse, rat TCF7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TCF7

    Clone
    Products:
         
    OriGene clones in human, mouse for TCF7 (see all 31)
    OriGene ORF clones in mouse, rat for TCF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): TCF7 (NM_201632)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCF7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF7

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TCF7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCF7_HUMAN, P36402: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18579517
    GO:0005667transcription factor complex IBA--

    TCF7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TCF7 About   (see all 22)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Endometrial cancer
    Endometrial cancer0.45
    Colorectal cancer0.42
    Signal transduction PTEN pathway0.45
    Acute myeloid leukemia0.40
    2Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40
    4beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79
    5Human Embryonic Stem Cell Pluripotency
    Factors Promoting Cardiogenesis in Vertebrates0.50
    Human Embryonic Stem Cell Pluripotency0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TCF7
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TCF7 (see all 9)
        MAPK Signaling
    ILK Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    GSK3 Signaling
    Prolactin Signaling

    1 Cell Signaling Technology (CST) Pathway for TCF7
        Wnt / Hedgehog / Notch

    3 GeneGo (Thomson Reuters) Pathways for TCF7
        Cytoskeleton remodeling Integrin outside-in signaling
    Signal transduction PTEN pathway
    Cell adhesion Tight junctions

    3 BioSystems Pathways for TCF7
        Wnt Signaling Pathway and Pluripotency
    Arrhythmogenic right ventricular cardiomyopathy
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    4 Reactome Pathways for TCF7
        deactivation of the beta-catenin transactivating complex
    Ca2+ pathway
    binding of TCF/LEF:CTNNB1 to target gene promoters
    formation of the beta-catenin:TCF transactivating complex


    Selected Kegg Pathways  (Kegg details for TCF7) (see all 12):
        Wnt signaling pathway
    Hippo signaling pathway
    Adherens junction
    Melanogenesis
    Pathways in cancer


    TCF7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TCF7: 
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TCF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TCF7 (P364021, 2, 3 ENSP000003403474) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCRP112742, 3, ENSP000003035074MINT-1779661 I2D: score=1 STRING: ENSP00000303507
    CTNNB1P352221, 2, 3, ENSP000003444564EBI-2119465,EBI-491549 MINT-7023938 MINT-1779680 I2D: score=2 STRING: ENSP00000344456
    GSK3BP498413, ENSP000003248064I2D: score=1 STRING: ENSP00000324806
    SS18L1O751773, ENSP000003330124I2D: score=1 STRING: ENSP00000333012
    RUNX3Q137613, ENSP000003434774I2D: score=1 STRING: ENSP00000343477
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006955immune response TAS1569101
    GO:0007420brain development IBA--

    TCF7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCF7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TCF7 gene (6 alternative transcripts): 
    NM_001134851.2  NM_003202.3  NM_201632.3  NM_201634.3  NM_213648.3  NM_001134852.1  

    Unigene Cluster for TCF7:

    Transcription factor 7 (T-cell specific, HMG-box)
    Hs.573153  [show with all ESTs]
    Unigene Representative Sequence: NM_001134851
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000342854 ENST00000395029(uc003kyt.3) ENST00000518887 ENST00000522653(uc003kyu.2)
    ENST00000517851 ENST00000521639 ENST00000522375 ENST00000378560(uc003kyv.3 uc003kyw.3 uc003kyy.3 uc003kyz.3 uc003kza.3)
    ENST00000520958 ENST00000518915 ENST00000395023(uc003kyx.3 uc003kzb.3 uc010jdu.3)
    ENST00000519447 ENST00000517741 ENST00000519165 ENST00000520652 ENST00000519037
    ENST00000521970 ENST00000517478
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TCF7 (see all 48):
    hsa-miR-100* hsa-miR-3607-3p hsa-miR-631 hsa-miR-485-3p hsa-miR-30d hsa-miR-624 hsa-miR-3921 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidTCF7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TCF7
    Predesigned siRNA for gene silencing in human, mouse, rat TCF7
    Clone
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    OriGene clones in human, mouse for TCF7 (see all 31)
    OriGene ORF clones in mouse, rat for TCF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): TCF7 (NM_201632)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCF7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF7
    Primer
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    OriGene qPCR primer pairs and template standards for TCF7
    OriGene qSTAR qPCR primer pairs in human, mouse for TCF7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TCF7
      QuantiTect SYBR Green Assays in human, mouse, rat TCF7
      QuantiFast Probe-based Assays in human, mouse, rat TCF7

    Additional mRNA sequence: 

    AK057580.1 AK093530.1 AK310591.1 AL832816.1 BC048769.1 BC072023.1 NR_033449.1 X59869.1 
    X59870.1 X59871.1 Z47361.1 Z47362.1 Z47363.1 Z47364.1 

    24 DOTS entries:

    DT.100028013  DT.100028014  DT.40280515  DT.100790464  DT.100790465  DT.100790462  DT.75131395  DT.100790463 
    DT.120861922  DT.91999036  DT.95129214  DT.120861862  DT.120861876  DT.100790461  DT.120861850  DT.91689593 
    DT.91970497  DT.92041293  DT.120861879  DT.120861918  DT.120861924  DT.95095927  DT.97844516  DT.95194636 

    Selected AceView cDNA sequences (see all 138):

    BQ223073 BM851321 BQ651010 NM_201634 BP431393 AA309508 AI805261 BM761617 
    AA313134 BM558017 BM741126 AA319339 NM_213648 BM845721 Z47363 BP367627 
    BQ650057 BM844333 NM_003202 AK131428 BQ653991 NM_201632 BQ645119 BF912800 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TCF7 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^
    SP1:        -           -     -     -     -           -     -     -                             -     -                 -     -     -     -                     
    SP2:                                -     -           -     -     -                             -     -                 -     -     -     -                     
    SP3:                                -     -           -     -     -                             -     -                 -     -     -     -                     
    SP4:                                -     -           -     -     -                             -     -                 -     -     -     -                     
    SP5:                                                                                            -     -                 -     -     -     -                     

    ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c
    SP1:              -                 -     -     -     -               
    SP2:              -                 -           -                     
    SP3:              -                 -     -                           
    SP4:              -                 -     -     -     -               
    SP5:              -                 -           -     -               


    ECgene alternative splicing isoforms for TCF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCF7 expression in normal human tissues (normalized intensities)      TCF7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TCF7 Expression
    About this image


    TCF7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocytes Zeugopod Epiphyseal End
             Membranous Facial Bones
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Peripheral Blood
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
    TCF7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCF7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.573153

    UniProtKB/Swiss-Prot: TCF7_HUMAN, P36402
    Tissue specificity: Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells
    and in the basal epithelial cells of mammary gland epithelium

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TCF7: 
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TCF7 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcf75 transcription factor 7, T cell specific   --   11 (31.86 cM) 52252371 
    chicken
    (Gallus gallus)
    Aves TCF16
    Gallus gallus transcription factor 7 (T-cell speci...
    58(a)
    1 ↔ 1
    13(15239292-15297080)
    lizard
    (Anolis carolinensis)
    Reptilia TCF76
    transcription factor 7 (T-cell specific, HMG-box)
    64(a)
    1 ↔ 1
    2(130679476-130809461)
    zebrafish
    (Danio rerio)
    Actinopterygii tcf76
    transcription factor 7 (T-cell specific, HMG-box)
    59(a)
    1 ↔ 1
    21(43960986-44022195) ENSDARG00000038672
    fruit fly
    (Drosophila melanogaster)
    Insecta pan3 heart development transcription factor 46(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea pop-16
    Protein POP-1 (pop-1) mRNA, complete cds
    19(a)
    1 → many
    I(2823468-2830293) WBGene00004077


    ENSEMBL Gene Tree for TCF7 (if available)
    TreeFam Gene Tree for TCF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCF7 gene
    LEF12  TCF7L12  TCF7L22  
    6 SIMAP similar genes for TCF7 using alignment to 13 protein entries:     TCF7_HUMAN (see all proteins):
    DKFZp586H0919    TCF7L2    LEF1    CIC    SRY    soxB

    TCF7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCF7 (see all 753)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1502165951,2
    C--128645324(+) CCTAA-/CCCCCC 6 -- int10--------
    rs1379395321,2
    C--128649242(+) CATGA-/CTCAAGA 6 -- int10--------
    rs754017511,2
    C--128658606(+) AGGCC-/TGTGGT 6 -- int10--------
    rs1500889521,2
    C--128669314(+) CAAAC-/AAGAGTC 1 -- ds50010--------
    rs3728510571,2
    C--133457276(+) CTCCT-/A/AA  
            
    AAAAA
    6 -- int10--------
    rs600038701,2
    C--133464633(+) GGAGG-/TTCAGA 6 -- int10--------
    rs58715231,2
    C--133473402(+) AGGCC-/CATGCC 6 -- int10--------
    rs785845661,2
    C--133477102(+) CAGTG-/CCAAAT 6 -- int10--------
    rs2017634341,2
    C--133723318(+) CTCAC-/TGTTGTTG 1 -- us2k10--------
    rs1473244331,2
    C--133723511(+) CTGTCC/GCAGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TCF7 (133450402 - 133487556 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TCF7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678103CNV Deletion23128226
    nsv5011CNV Insertion18451855

    Human Gene Mutation Database (HGMD): TCF7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCF7
    DNA2.0 Custom Variant and Variant Library Synthesis for TCF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 189908    OMIM disorders: --

    Selected diseases for TCF7 (see all 32):    About MalaCards
    peripheral t-cell lymphoma    venous thromboembolism    aplastic anemia    idiopathic pulmonary fibrosis
    kawasaki disease    thromboembolism    pulmonary fibrosis    urethritis
    thyroid cancer    basal cell carcinoma    migraine    colorectal cancer
    acute myeloid leukemia    encephalitis    encephalomyelitis    type 1 diabetes
    lymphoblastic leukemia    insulin resistance    multiple sclerosis    osteosarcoma

    1 disease from the University of Copenhagen DISEASES database for TCF7:
    Diabetes mellitus

    TCF7 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for TCF7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 38.2 5 19749792 (2), 18983819 (2), 17893322 (1)
    colorectal cancer 11.6 2 9259402 (2)
    tumors 9.41 6 11326276 (1), 14633602 (1), 10679386 (1)
    gastric cancer 0 3 11085512 (1)
    lymphoma 0 2 12707037 (1)
    cancer 0 1 10679386 (1)

    Genetic Association Database (GAD): TCF7
    Human Genome Epidemiology (HuGE) Navigator: TCF7 (19 documents)

    Export disorders for TCF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCF7 gene, integrated from 10 sources (see all 124):
    (articles sorted by number of sources associating them with TCF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization. (PubMed id 1569101)1, 2, 9 van de Wetering M.... Clevers H. (J. Biol. Chem. 1992)
    2. A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. (PubMed id 12765974)1, 4, 9 Noble J.A....Erlich H.A. (Diabetes 2003)
    3. Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients. (PubMed id 20536507)1, 4 Wang Y....Chan J.C. (Diabet. Med. 2010)
    4. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    5. Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women. (PubMed id 20613673)1, 4 Lee D.Y....Kim J.G. (Menopause 2010)
    6. Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism. (PubMed id 20603037)1, 4 Beckers M.M....Biesma D.H. (Eur. J. Intern. Med. 2010)
    7. Single nucleotide polymorphisms in the Wnt and BMP pathways and colorectal cancer risk in a Spanish cohort. (PubMed id 20844743)1, 4 FernA!ndez-Rozadilla C....Ruiz-Ponte C. (PLoS ONE 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Polymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay. (PubMed id 19028820)1, 4 Greisenegger S....Mannhalter C. (Clin. Chem. 2009)
    10. A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. (PubMed id 19131662)1, 4 Wang X....Cook N.R. ( a journal of cerebral circulation 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6932 HGNC: 11639 AceView: TCF7 Ensembl:ENSG00000081059 euGenes: HUgn6932
    ECgene: TCF7 Kegg: 6932 H-InvDB: TCF7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCF7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TCF7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCF7 gene:
    Search GeneIP for patents involving TCF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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