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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TCF4 Gene

protein-coding GIFtS: 66
GCID: GC18M052889

transcription factor 4

Explore 47 diseases affiliated with
TCF4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transcription Factor 4¹ ²		ITF-2² ³
ITF2¹ ² ³ ⁵		SEF-2² ³
BHLHb19¹		TCF-4² ³
SEF2² ³ ⁵		SL3-3 Enhancer Factor 2² ³
E2-2¹ ²		PTHS² ⁵
SEF2-1B¹ ²		SEF2-1²
Class B Basic Helix-Loop-Helix Protein 19² ³		SEF2-1A²
Immunoglobulin Transcription Factor 2² ³		BHLHB19³

External Ids:	HGNC: 11634¹	Entrez Gene: 6925²	Ensembl: ENSG00000196628⁷	OMIM: 602272⁵	UniProtKB: P15884³

Export aliases for TCF4 gene to outside databases

Previous GC identifers: GC18M052983 GC18M052797 GC18M052679 GC18M051043 GC18M051045 GC18M049599

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCF4:

This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes

an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is

broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of

Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been

described. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: ITF2_HUMAN, P15884

Function: Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation

of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box

present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity).

Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'

Gene Wiki entry for TCF4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_025028.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TCF4 gene promoter:
FOXD3 C/EBPalpha E47 CREB SRY Nkx6-1 deltaCREB POU2F1a Zic3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TCF4 promoter sequence

Search SABiosciences Chromatin IP Primers for TCF4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1 Ensembl cytogenetic band: 18q21.2 HGNC cytogenetic band: 18q21.1

TCF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCF4 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M052889: view genomic region (about GC identifiers)

Start:	52,889,562 bp from pter	End:	53,332,018 bp from pter
Size:	442,457 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITF2_HUMAN, P15884 (See protein sequence)

Recommended Name: Transcription factor 4

Size: 667 amino acids; 71308 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with

myogenin. Interacts with HIVEP2. Interacts with NEUROD2 (By similarity)

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=AAA60310.1; Type=Miscellaneous discrepancy; Note=Incomplete and probable erroneous sequence;

Sequence=AAA60312.1; Type=Miscellaneous discrepancy; Note=Incomplete and probable erroneous sequence;

1 PDB 3D structure from and Proteopedia for TCF4:

2KWF (3D)

Secondary accessions: B3KT62 B3KUC0 B4DT37 B4DUG3 G0LNT9 G0LNU0 G0LNU1 G0LNU2 G0LNU8 G0LNU9 G0LNV0

G0LNV1 Q08AP2 Q08AP3 Q15439 Q15440 Q15441

Alternative splicing: 11 isoforms: P15884-1 P15884-2 P15884-3 P15884-4 P15884-5 P15884-6 P15884-7 P15884-8

P15884-9 P15884-10 P15884-11

Explore the universe of human proteins at neXtProt for TCF4: NX_P15884

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P15884

TCF4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (12 alternative transcripts):

NP_001077431.1 NP_001230155.1 NP_001230156.1 NP_001230157.1 NP_001230159.1 NP_001230160.1 NP_001230161.1 NP_001230162.1

NP_001230163.1 NP_001230164.1 NP_001230165.1 NP_003190.1

ENSEMBL proteins:

ENSP00000348374 ENSP00000455135 ENSP00000409447 ENSP00000439656 ENSP00000445202

ENSP00000440731 ENSP00000457649 ENSP00000455346 ENSP00000439827 ENSP00000441562

ENSP00000455179 ENSP00000457765 ENSP00000455984 ENSP00000455763 ENSP00000455261

ENSP00000454366 ENSP00000455418 ENSP00000456125 ENSP00000457263 ENSP00000381382

ENSP00000454647 ENSP00000468729 ENSP00000455304 ENSP00000456983 ENSP00000457392

ENSP00000455071 ENSP00000458122 ENSP00000456802 ENSP00000457245 ENSP00000454584

ENSP00000468277 ENSP00000456220 ENSP00000457113 ENSP00000455163 ENSP00000456917

ENSP00000457747 ENSP00000454328 ENSP00000455450 ENSP00000454866 ENSP00000454352

ENSP00000457082 ENSP00000454441 ENSP00000346440

Reactome Protein details: P15884
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): TCF4 OriGene Protein Over-expression Lysate (see all 2): TCF4 OriGene Custom Protein Services for TCF4
	GenScript Custom Purified and Recombinant Proteins Services for TCF4
	Novus Biologicals TCF4 Protein Novus Biologicals TCF4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TCF4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	1681116
GO:0005667	transcription factor complex	ISS	8978694

TCF4 for ontologies About GeneDecksing

TCF4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for TCF4
	GenScript Custom Superior Antibodies Services for TCF4
	Novus Biologicals TCF4 Antibodies
	Search for Antibodies for TCF4 at Abcam
	Uscn Antibodies for TCF4
	ThermoFisher Antibodies for TCF4

Assay Products for TCF4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TCF4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TCF4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TCF4 for domains About GeneDecksing

1 InterPro domain/family:

IPR011598 HLH_dom

Graphical View of Domain Structure for InterPro Entry P15884

ProtoNet protein and cluster: P15884

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: ITF2_HUMAN, P15884

Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription

factors

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ITF2_HUMAN, P15884

Function: Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation

of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box

present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity).

Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'

Genatlas biochemistry entry for TCF4:

transcription factor 4,with several alternatively spliced isoforms

		10/578 SABiosciences Target genes for TCF4 (see all 578):
		AASDH ABCA7 ACR ACTBL2 AFAP1L1 AGAP4 AGAP7 AGAP8 AGBL3 AGBL4

miRNA Products:		miRTarBase miRNAs that target TCF4: hsa-mir-204 (MIRT005846)

		OriGene 3'-UTR Clone (see all 2): TCF4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCF4
		8/187 QIAGEN miScript miRNA Assays for microRNAs that regulate TCF4 (see all 187):
		hsa-miR-193a-3p hsa-miR-106a hsa-miR-4305 hsa-miR-605 hsa-miR-128 hsa-miR-138-2* hsa-miR-519a hsa-miR-200b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCF4 (see all 7) OriGene shRNA RFP: TCF4 OriGene siRNA: TCF4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCF4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TCF4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCF4 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCF4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TCF4 (NM_001083962)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCF4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TCF4
		Search LifeMap BioReagents cell lines for TCF4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF4

Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	ISS	8978694
GO:0001011	sequence-specific DNA binding RNA polymerase recruiting transcription factor activity	ISS	8978694
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	ISS	8978694
GO:0001087	TFIIB-class binding transcription factor activity	ISS	8978694
GO:0001093	TFIIB-class transcription factor binding	ISS	8978694

TCF4 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for TCF4:

Increased cell death HMECs cel

Increased viability with TRAIL

Wnt reporter downregulated

Animal Models:
Mouse knock-outs for TCF4: Tcf4^tm1Zhu Tcf4^tm1.1Hmb
8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Tcf4):

cellular	growth/size	hearing/vestibular/ear	hematopoietic system	immune system
mortality/aging	nervous system	skeleton

TCF4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Rho Family GTPases

	Molecular Mechanisms of Cancer	0.51			ILK Signaling	0.45
	MAPK Signaling	0.51

Human Embryonic Stem Cell Pluripotency

Human Embryonic Stem Cell Pluripotency

1.00

Factors Promoting Cardiogenesis in Vertebrates

0.50

Activation of p38 alpha/beta MAPK

CDO in myogenesis

0.55

Myogenesis

0.55

Selected targets of Oct-3/4

Selected targets of Oct-3/4

1.00

Neural Crest Differentiation

Neural Crest Differentiation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TCF4

Selected targets of Oct-3/4

5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCF4 (see all 10)

	MAPK Signaling
	Factors Promoting Cardiogenesis in Vertebrates
	Molecular Mechanisms of Cancer
	Colorectal Cancer Metastasis
	Glioblastoma Multiforme

4 BioSystems Pathways for TCF4

	Neural Crest Differentiation
	Wnt Signaling Pathway NetPath
	Regulation of Wnt-mediated beta catenin signaling and target gene transcription
	Coregulation of Androgen receptor activity

3 Reactome Pathways for TCF4

	Developmental Biology
	Myogenesis
	CDO in myogenesis

TCF4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TCF4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/53 Interacting proteins for TCF4 (P15884^{1, 2, 3} ENSP00000346440⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 53)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTNNB1	P35222¹^,²^,³, ENSP00000344456⁴	EBI-533224,EBI-491549 MINT-8399030 MINT-8398882 MINT-8398896 MINT-8398917 MINT-4508268 MINT-8398937 MINT-8398969 MINT-8398862 MINT-4508065 I2D: score=7 STRING: ENSP00000344456
ASCL1	P50553¹^,³, ENSP00000266744⁴	EBI-533224,EBI-957042 I2D: score=4 STRING: ENSP00000266744
FERMT2	Q96AC1²	MINT-8398937 MINT-8399030 MINT-8398862 MINT-8398882 MINT-8398896 MINT-8398917 MINT-8398954
CALM1	P62158³, ENSP00000349467⁴	I2D: score=7 STRING: ENSP00000349467
CALM2	P62158³, ENSP00000272298⁴	I2D: score=7 STRING: ENSP00000272298

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0006352	DNA-dependent transcription, initiation	ISS	8978694
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006367	transcription initiation from RNA polymerase II promoter	ISS	8978694
GO:0045666	positive regulation of neuron differentiation	ISS	--

TCF4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TCF4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TCF4
2 Novoseek chemical compound relationships for TCF4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mononucleotide	48.4	3	10918391 (2)
glycogen	32	2	12603528 (1), 14687479 (1)

Search CenterWatch for drugs/clinical trials and news about TCF4 / ITF2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TCF4 gene (12 alternative transcripts):

NM_001083962.1 NM_001243226.1 NM_001243227.1 NM_001243228.1 NM_001243230.1 NM_001243231.1 NM_001243232.1 NM_001243233.1

NM_001243234.1 NM_001243235.1 NM_001243236.1 NM_003199.2

Unigene Cluster for TCF4:

Transcription factor 4

Hs.605153 [show with all ESTs]

Unigene Representative Sequence: NM_001083962

18/48 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 48):

ENST00000356073 ENST00000568673 ENST00000457482 ENST00000543082 ENST00000540999

ENST00000537578 ENST00000564999 ENST00000568740 ENST00000562680 ENST00000537856

ENST00000544241 ENST00000561992 ENST00000561831 ENST00000565018 ENST00000570287

ENST00000564228 ENST00000567880 ENST00000566286

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TCF4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCF4
		8/187 QIAGEN miScript miRNA Assays for microRNAs that regulate TCF4 (see all 187):
		hsa-miR-193a-3p hsa-miR-106a hsa-miR-4305 hsa-miR-605 hsa-miR-128 hsa-miR-138-2* hsa-miR-519a hsa-miR-200b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCF4 (see all 7) OriGene shRNA RFP: TCF4 OriGene siRNA: TCF4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCF4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCF4 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCF4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TCF4 (NM_001083962)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCF4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCF4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TCF4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCF4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCF4

Additional cDNA sequence:

AB209741.1 AK021980.1 AK026674.1 AK095041.1 AK095066.1 AK096862.1 AK122765.1 AK299169.1

AK300038.1 AK300612.1 AK300636.1 AK301144.1 AK315074.1 AK316165.1 BC031056.1 BC125084.1

BC125085.1 FR748202.1 FR748203.1 FR748205.1 FR748207.1 FR748208.1 FR748209.1 FR748210.1

FR748211.1 FR748212.1 FR748213.1 FR748214.1 FR748215.1 FR748216.1 FR748217.1 FR748218.1

FR748219.1 FR748220.1 FR748221.1 FR748222.1 FR748223.1 M74718.1 M74719.1 M74720.1

X52079.1

24/47 DOTS entries (see all 47):

DT.448128 DT.86840324 DT.100892351 DT.100806486 DT.121101533 DT.100892349 DT.95169893 DT.100808993

DT.441773 DT.95292982 DT.121101581 DT.95169897 DT.121101588 DT.87079130 DT.100789378 DT.75148455

DT.75182387 DT.100892345 DT.100789379 DT.100753719 DT.75169556 DT.100892346 DT.40115779 DT.92447456

24/512 AceView cDNA sequences (see all 512):

AA287187 T55908 AI291882 AI784460 AI431709 BM661935 AI003998 AA865756

AI097389 AI492030 AA861728 CD672923 AA232583 AU122270 BE795544 D61472

BU069915 BF057715 AA669136 BX420631 AA287097 BM800432 AI174523 AU120247

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for TCF4 (see all 13) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	·	17c	^	18	^	19	^	20	^	21a	·	21b	^	22a	·
SP1:											-						-				-		-		-						-																-
SP2:											-						-				-		-		-						-																-
SP3:																	-				-		-		-						-																-
SP4:																					-		-		-						-																-
SP5:																																															-

ExUns:	22b	^	23	^	24a	·	24b	·	24c	^	25a	·	25b	^	26	^	27a	·	27b
SP1:									-		-
SP2:											-
SP3:									-		-
SP4:											-
SP5:

ECgene alternative splicing isoforms for TCF4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TCF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGACAGATGT

About this image

TCF4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Branchial Arch 1

Cranial Tendons Cells

Selective marker (cell-identifying gene)

Tendons & Ligaments

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Eye

Inner Nuclear Layer

AII Amacrine Cells

Amacrine, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TCF4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCF4

SOURCE GeneReport for Unigene cluster: Hs.605153

UniProtKB/Swiss-Prot: ITF2_HUMAN, P15884

Tissue specificity: Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In

developing embryonic tissues, expression mostly occurs in the brain

SABiosciences Expression via Pathway-Focused PCR Arrays including TCF4:

WNT Signaling Targets in human mouse rat

WNT Signaling Pathway in human mouse rat

Liver Cancer in human mouse rat

Epithelial to Mesenchymal Transition (EMT) in human mouse rat

Cardiotoxicity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCF4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TCF4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCF4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCF4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TCF4 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	TCF4⁶ --	--	95(a) 72(a)	1 ↔ 1 possible ortholog	GL343213.1(526409-578219) AAWZ02036688(11541-14447)
African clawed frog (Xenopus laevis)	Amphibia	CF342043.1²	--	80.67(n)		CF342043.1
zebrafish (Danio rerio)	Actinopterygii	CABZ01109624.1⁶ tcf4⁶	transcription factor 4	78(a) 73(a)	possible ortholog 1 ↔ 1	21(1794705-1800202) 21(1602919-1689003)
fruit fly (Drosophila melanogaster)	Insecta	da³	oogenesis transcription factor	78(a)		--
worm (Caenorhabditis elegans)	Secernentea	hlh-2⁶	Helix Loop Helix family member (hlh-2)	25(a)	1 → many	I(7190846-7193914)

ENSEMBL Gene Tree for TCF4 (if available)
TreeFam Gene Tree for TCF4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TCF4 gene

TCF12² TCF3²

18/69 SIMAP similar genes for TCF4 using alignment to 34 protein entries: ITF2_HUMAN (see all proteins) (see all similar genes):

EML2 HOOK2 VPS33A CRCP NXPE2 DCTN5

DNAPTP3 TCF12 SH3PXD2A ZNF212 C4orf21 LAMB4

ZNF283 ZNF527 PLEKHH2 APOPT1 BTBD2 ERBB2

TCF4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75090842^1,2	F,	--	49599560(+)	`CTACCG/ACGGGC`	12	--	ut3¹		1		EA	120
rs1261083^1,2		--	49600217(-)	`AAACAT/CACAAA`	12	--	ut3¹		1		MN	184
rs78248109^1,2		--	49600308(+)	`ATATGA/GACAAT`	12	--	ut3¹		0	--	--	--	--
rs116613924^1,2	C,F,	--	49600399(+)	`TTCATC/TGAATA`	12	--	ut3¹		1		WA	118
rs61524834^1,2		--	49600492(+)	`GGACAC/GTTCTA`	12	--	ut3¹		0	--	--	--	--
rs111302418^1,2		--	49601532(+)	`CAAATT/AAAAAA`	12	--	ut3¹		1		CSA	2
rs76640061^1,2	C,F,	--	49601978(+)	`TTTTTT/CTCTTT`	12	--	ut3¹		1		NA	120
rs201446935^1,2	C	--	49603787(+)	`TTAAAC/TCNNNN`	12	--	ut3¹		0	--	--	--	--
rs200323049^1,2	C	--	49603789(-)	`GGCTGG/TGATTT`	12	--	ut3¹		0	--	--	--	--
rs1799410^1,2	C	--	49604123(+)	`CAGGGA/GAAGGG`	12	--	ut3¹		2		MN NA	186
rs199626082^1,2	C	--	49604141(+)	`TAAGAA/CCAAAA`	12	--	ut3¹		0	--	--	--	--
rs200670559^1,2	C	--	49604142(+)	`AAGACA/CAAAAA`	12	--	ut3¹		0	--	--	--	--
rs115039389^1,2	C,F,	--	49604478(+)	`GTTCAT/CGTAGT`	12	--	ut3¹		1		WA	118
rs111947783^1,2	C,	--	49604876(+)	`CAGCTG/TTTAAG`	12	--	ut3¹		1		NA	2
rs11152294^1,2	C,F,	--	49605525(+)	`AGTTGC/TAATAT`	12	--	int¹		3		WA CSA	122
rs8087569^1,2	C,	--	49605663(+)	`TGCTCA/GAGACT`	12	--	int¹		3		WA NA	240
rs8087570^1,2	C,	--	49605666(+)	`TCAAGA/GCTGGC`	12	--	int¹		3		WA NA	240
rs41339445^1,2	C,F,H,	--	49606293(-)	`TGTAAC/ACCCAT`	12	--	int¹		16		NA NS EA WA	2046
rs112675011^1,2		--	49606776(+)	`GACCAC/TGACCT`	12	--	int¹		1		CSA	1
rs59770744^1,2	C,	--	49606849(+)	`CTGGAC/TGATAT`	12	--	int¹		3		WA NA	240
rs56997593^1,2	C,	--	49607319(+)	`GTGCAC/TGACGT`	12	--	int¹		3		WA NA	240
rs76774700^1,2	F,	--	49607320(+)	`TGCACG/AACGTC`	12	--	int¹		1		WA	118
rs77606899^1,2	F,	--	49607322(+)	`CACGAC/TGTCTT`	12	--	int¹		1		WA	118
rs78857663^1,2		--	49607361(+)	`ATAAAG/ACTCTG`	12	--	int¹		1		NA	120
rs57457059^1,2	C,	--	49607519(+)	`TCACAC/TATTGG`	12	--	int¹		3		WA NA	240
rs8094273^1,2	C,F,H,	--	49607743(+)	`TCTTCG/AGTTGC`	12	--	int¹		15		NS EA NA WA	1638
rs41478353^1,2	C,F,	--	49607791(+)	`AAGAAC/TACTTG`	12	--	int¹		6		NA WA	252
rs13381817^1,2	C,F,H,	--	49607882(+)	`GTAAGC/TGCCTT`	12	--	int¹		9		NS EA NA	978
rs73487008^1,2	C,	--	49608537(+)	`GAAAAA/CGACAA`	12	--	int¹		3		WA NA	240
rs80318671^1,2	F,	--	49608794(+)	`TCAAAA/CACCAT`	12	--	int¹		1		WA	118
rs74999248^1,2	F,	--	49608962(+)	`TATACA/CTCAGC`	12	--	int¹		1		WA	118
rs2272285^1,2	H	--	49609697(-)	`ACAGAT/CAGCAG`	12	--	int¹		5		EA NS	1904
rs73487011^1,2	C,	--	49610612(+)	`GGAGGC/TTGAGG`	12	--	int¹		2		WA NA	122
rs72925010^1,2	C,F,	--	49610776(+)	`ACCCAT/CACATA`	12	--	int¹		1		NA	120
rs41483647^1,2	C,F,H,	--	49611270(+)	`AACACA/GATTAG`	12	--	int¹		23		NS EA NA WA	2726
rs56828204^1,2	C,	--	49612233(+)	`TGCCAC/ACACAC`	12	--	int¹		4		WA CSA NA	242
rs59231191^1,2	C,	--	49612346(+)	`TCTGAC/TCCTAG`	12	--	int¹		3		CSA WA NA	240
rs7237259^1,2	C,F,A,H,	--	49612548(+)	`AACATG/CAAGCA`	12	--	int¹		17		NS EA NA WA CSA	1970
rs73487018^1,2	C,	--	49613171(+)	`GTGTCG/TCAACA`	12	--	int¹		4		WA CSA NA	242
rs73487020^1,2	C,	--	49613263(+)	`TTCCAT/GTTTTA`	12	--	int¹		4		WA CSA NA	242
rs73487022^1,2	C,	--	49613335(+)	`GTGGCG/ATTAAG`	12	--	int¹		4		WA CSA NA	242
rs73487023^1,2	C,	--	49613345(+)	`GTACAA/GACCTT`	12	--	int¹		4		WA CSA NA	242
rs79695232^1,2	F,	--	49613440(+)	`ACCACG/ACCCAC`	12	--	int¹		1		NA	120
rs7238493^1,2	C,F,	--	49613468(+)	`TGTAAC/TTCACT`	12	--	int¹		1		WA	118
rs10515969^1,2	C,F,H,	--	49613477(+)	`CTCTCT/CTATAT`	12	--	int¹		96		NS EA NA PA EU CA WA CSA	5810
rs56970782^1,2	C,	--	49613626(+)	`TTTTAC/TAGGCC`	12	--	int¹		2		WA	120
rs59237299^1,2	C,	--	49615071(+)	`TACTTC/TGTTAA`	12	--	int¹		3		WA NA	240
rs1261071^1,2		--	49615439(+)	`TTAGTG/AGGGTA`	12	--	int¹		1		MN	184
rs73487028^1,2	C,	--	49615636(+)	`TGCCCT/CCTCAT`	12	--	int¹		3		WA NA	240
rs191054354^1,2	C,	--	49615906(+)	`GTCCCA/GTCCAC`	12	--	int¹		0	--	--	--	--
rs7228712^1,2	C,F,	--	49616882(+)	`ATTCTA/CCCATA`	12	--	int¹		1		WA	118
rs7240303^1,2	C,H	--	49616975(+)	`ATATAC/TTATTA`	12	--	int¹		3		NS NA	104
rs112269460^1,2	C,	--	49617051(+)	`TAGATT/ATTTTT`	12	--	int¹		1		NA	2
rs1261072^1,2	O,H,	--	49617276(+)	`AGTACT/CAGATT`	12	--	int¹		4		NS EA	418
rs75425155^1,2	F,	--	49617635(+)	`TAGTAC/TATGTG`	12	--	int¹		1		WA	118
rs1261074^1,2	C,F,H,	--	49617729(+)	`ATGTCG/AGGAGA`	12	--	int¹		13		NS EA NA WA CSA	1392
rs1261075^1,2		--	49617752(+)	`TGTCTA/TGAGAA`	12	--	int¹		0	--	--	--	--
rs72925028^1,2		--	49618071(+)	`TCATAC/TGTTCC`	12	--	int¹		0	--	--	--	--
rs948766^1,2	C,	--	49618402(+)	`AATGCC/TTGAAG`	12	--	int¹		4		NA WA	124
rs1261077^1,2		--	49618472(+)	`AGTCCA/GGGTGG`	12	--	int¹		0	--	--	--	--
rs75648717^1,2		--	49619081(+)	`AAACAC/TATTCA`	12	--	int¹		1		EA	120
rs78071632^1,2	F,	--	49619164(+)	`TGTCTC/GCATTT`	12	--	int¹		1		WA	118
rs41515848^1,2	C,F,H,	--	49619435(-)	`ATAGAC/TGTGTT`	12	--	int¹		24		NS EA NA WA	2726
rs75373793^1,2	C,	--	49619506(+)	`GAAAGG/TAGTGC`	12	--	int¹		2		WA	120
rs1788017^1,2	C,A,H,	--	49619601(+)	`acaggC/Tgtgca`	12	--	int¹		3		WA NA	122
rs113820159^1,2	C,	--	49620435(+)	`CGTTTTTTG/- TTTGT`	12	--	int¹		1		CSA	2
rs73487032^1,2	C,	--	49620812(+)	`ACATGA/CGTTCT`	12	--	int¹		2		WA	120
rs73957089^1,2	C,	--	49622536(+)	`TGAAAC/TGCCTT`	12	--	int¹		2		WA	120
rs8092938^1,2	C,F,H,	--	49623749(+)	`GTTGAC/GCACCA`	12	--	int¹		6		NS EA CSA WA	537
rs77109773^1,2	F,	--	49624191(+)	`CATTAA/GACAGG`	12	--	int¹		1		NA	120
rs78328098^1,2		--	49624595(+)	`TATTTA/GAAGAT`	12	--	int¹		0	--	--	--	--
rs1942266^1,2	C,F,	--	49624613(-)	`TCTAGA/GCGAAA`	12	--	int¹		4		NA EA WA	370
rs28558174^1,2		--	49624693(+)	`GGGCAA/GTTCTA`	12	--	int¹		0	--	--	--	--
rs72925036^1,2		--	49624740(+)	`TTTGGA/GCTGGA`	12	--	int¹		0	--	--	--	--
rs75933755^1,2	F,	--	49625333(+)	`AATAAC/GTGCCA`	12	--	int¹		1		WA	118
rs74789987^1,2	F,	--	49625423(+)	`TAGGGC/ACAACT`	12	--	int¹		1		WA	118
rs59117361^1,2	C,	--	49625714(+)	`AGCCTG/CCTGAG`	12	--	int¹		1		WA	2
rs78222363^1,2		--	49625987(+)	`GCTGAC/TTTCCA`	12	--	int¹		0	--	--	--	--
rs80091637^1,2	F,	--	49626057(+)	`ACTGAA/CGTTGT`	12	--	int¹		1		WA	118
rs11662517^1,2	C,H,	--	49626098(+)	`TCTCAT/AGTATA`	12	--	int¹		1		NA	120
rs74846024^1,2	F,	--	49626972(+)	`TGCTTT/CAATTT`	12	--	int¹		1		WA	118
rs111885969^1,2		--	49627209(+)	`AGCCAC/TGGAAT`	12	--	int¹		1		CSA	2
rs28398381^1,2	F,	--	49627261(+)	`GAAAAT/CCACAA`	12	--	int¹		1		WA	118
rs41452747^1,2	C,F,H,	--	49627996(-)	`TTTACC/TGAAAG`	12	--	int¹		18		NS EA NA	2416
rs57162287^1,2	C,	--	49628200(+)	`TAATAC/GTTAGT`	12	--	int¹		3		WA NA	240
rs79011899^1,2		--	49629671(+)	`AAGCCA/GGATTT`	12	--	int¹		0	--	--	--	--
rs10460153^1,2	C,	--	49630126(+)	`TTGTAT/CGTATT`	12	--	int¹		2		NA	4
rs114205820^1,2	C,	--	49630911(+)	`TCTAAT/CACGTG`	12	--	int¹		1		WA	118
rs62092441^1,2	C,	--	49631063(+)	`CAAGGG/TCTGGA`	12	--	int¹		2		NA	122
rs74810858^1,2	F,	--	49631107(+)	`AACGGG/CGATTC`	12	--	int¹		1		WA	118
rs78245018^1,2		--	49631278(+)	`AACAAC/TAGTAT`	12	--	int¹		0	--	--	--	--
rs11660217^1,2	C,F,H	--	49631344(+)	`CTTACC/TATGAG`	24	I M	mis¹ ese³		7		NS EA NA	416
rs62092443^1,2	C,	--	49631623(+)	`TTAGTC/TGACAA`	12	--	int¹		2		NA	122
rs77010658^1,2		--	49632089(+)	`TTCTGA/GCTTCC`	12	--	int¹		0	--	--	--	--
rs79699265^1,2		--	49633530(+)	`CTTCCC/TGCTAA`	12	--	int¹		1		EA	120
rs72925066^1,2		--	49633834(+)	`GGCTGC/GAGTTC`	12	--	int¹		0	--	--	--	--
rs11664966^1,2	C,H,	--	49633924(+)	`CAGGAC/TTTTAT`	12	--	int¹		0	--	--	--	--
rs74849864^1,2	F,	--	49634311(+)	`ACAGTC/TCTTTT`	12	--	int¹		1		NA	120
rs112454654^1,2	F,	--	49634440(+)	`CATAGT/ACTCAC`	12	--	int¹		2		CSA	5
rs7242437^1,2	C,	--	49634562(+)	`AAGGGT/CACAAA`	12	--	int¹		3		WA NA	240
rs12968091^1,2	C	--	49634887(+)	`AATGTA/Gaaata`	12	--	int¹		0	--	--	--	--
rs41437147^1,2	C,F,H,	--	49636192(+)	`GAAATT/CATTTA`	12	--	int¹		21		NS EA NA WA CSA	2304
rs74562156^1,2	F,	--	49636674(+)	`GTTATA/TGGAAT`	12	--	int¹		1		WA	118
rs35969244^1,2	C,F,H,	--	49637016(+)	`CAAAAT/CTGTCA`	12	--	int¹		20		NS EA NA WA	2394
rs77605902^1,2		--	49637214(+)	`GGTTGA/GACAGG`	12	--	int¹		2		CSA WA	120
rs75817520^1,2	C	--	49637916(+)	`ATTGTC/TTTTTT`	12	--	int¹		1		NA	2
rs12607331^1,2	H	--	49637963(+)	`TTTTAG/AAACTA`	12	--	int¹		4		NS EA	418
rs73488958^1,2	C,	--	49638181(+)	`GTTATG/ACAAGA`	12	--	int¹		1		WA	2
rs73957090^1,2	C,	--	49638604(+)	`AAAGTG/AGTTTC`	12	--	int¹		2		WA	120
rs1787801^1,2	H,	--	49639993(-)	`TGGGTG/CTGGGT`	12	--	int¹		4		NS EA	418
rs74416812^1,2	F,	--	49641106(+)	`TGAAAA/GTATTT`	12	--	int¹		1		NA	120
rs1787254^1,2	C	--	49641403(-)	`TCTTTC/TCCAGT`	12	--	int¹ trp³		0	--	--	--	--
rs79151843^1,2	F,	--	49641507(+)	`TGGGTT/CTGATG`	12	--	int¹		1		NA	120
rs2510130^1,2	C,H	--	49641645(+)	`AATTTT/GGGCTC`	12	--	int¹		5		NS EA NA	420
rs76035038^1,2		--	49641671(+)	`GCCCAA/CGAGAA`	12	--	int¹		0	--	--	--	--
rs73488961^1,2	C,	--	49642769(+)	`CCACGT/CATTAG`	12	--	int¹		3		WA NA	240
rs73957091^1,2	C,	--	49642869(+)	`AGTGTG/ATGTAG`	12	--	int¹		2		WA	120
rs80020368^1,2	F,	--	49643775(+)	`TGTTCT/AAGTGT`	12	--	int¹		1		WA	118
rs1261133^1,2	C,F,A,H,	--	49644577(-)	`CTAGCG/AGAATG`	12	--	int¹		17		NS EA NA WA	1414
rs80213626^1,2	C,F,	--	49644927(+)	`CCTGAT/CATGTC`	12	--	int¹		1		WA	118
rs56695457^1,2	C,	--	49645517(+)	`CATTTC/GAAAAC`	12	--	int¹		3		WA NA	240
rs76681900^1,2	C,	--	49645557(+)	`CTACAT/GAAGTG`	12	--	int¹		2		NA	122
rs1271156^1,2		--	49646084(+)	`AATTTA/TAAAAA`	12	--	int¹		0	--	--	--	--
rs73488963^1,2	C,	--	49646178(+)	`CCACAG/ATGTCA`	12	--	int¹		3		WA NA	240
rs73488965^1,2	C,	--	49647002(+)	`ACATAG/CCTTGG`	12	--	int¹		3		WA NA	240
rs1261113^1,2		--	49647421(+)	`TAGGAC/TCACAT`	12	--	int¹		1		NA	90
rs73488967^1,2	C,	--	49647457(+)	`TTTCCA/GTGCCC`	12	--	int¹		3		WA NA	240
rs13380888^1,2	C,	--	49647488(+)	`ATAGCT/CGGCAA`	12	--	int¹		3		NA	124
rs74410841^1,2		--	49647903(+)	`GTCACA/GGGTAT`	12	--	int¹		0	--	--	--	--
rs113619928^1,2		--	49648039(+)	`TTCCAC/TCATCT`	12	--	int¹		2		CSA WA	120
rs78161885^1,2	F,	--	49648154(+)	`TATTGT/CAAACT`	12	--	int¹		1		NA	120
rs76981160^1,2		--	49648173(+)	`GAATAG/CAGCTT`	12	--	int¹		1		WA	118
rs73488969^1,2	C,	--	49648331(+)	`TCTACG/ATATTA`	12	--	int¹		3		WA NA	240
rs73488970^1,2	C,	--	49648856(+)	`AATTAT/CAAATA`	12	--	int¹		3		WA NA	240
rs1261115^1,2	C,F,O,A,H,	--	49650144(+)	`AAAATA/GTTTTA`	12	--	int¹		9		MN NS EA WA NA	844
rs113310466^1,2	C,	--	49650365(+)	`CTTCAG/ATAAAA`	12	--	int¹		1		NA	2
rs112409752^1,2	C,	--	49650410(+)	`ACAACC/TAGATA`	12	--	int¹		1		NA	2
rs77765312^1,2		--	49650872(+)	`CTTAAA/GAGAAC`	12	--	int¹		1		WA	118
rs79787089^1,2	F,	--	49651826(+)	`TAACAT/CTCTAG`	12	--	int¹		1		WA	118
rs78648685^1,2		--	49652123(+)	`GATAGG/AAAAAA`	12	--	int¹		1		WA	2
rs1788054^1,2	H	--	49652178(-)	`CTATTT/AAAGTT`	12	--	int¹		4		NS EA	418
rs1787793^1,2	C,	--	49652715(+)	`TGTTGG/CTTAGC`	12	--	int¹		2		WA	120
rs76023551^1,2	C,F,	--	49653487(+)	`GATCTA/GCATTA`	12	--	int¹		1		WA	118
rs1799405^1,2	C,F,A,H,	--	49653641(+)	`TTTATA/TTAGTA`	12	--	int¹		8		NS EA WA NA	660
rs202128172^1,2	C	--	49654469(-)	`GAAAAA/GCAAAA`	12	--	int¹		0	--	--	--	--
rs114666081^1,2	C,F,	--	49654764(+)	`ATAACT/CGAAGG`	12	--	int¹		1		WA	118
rs56666482^1,2	C,	--	49654878(+)	`CACACG/AGGCTC`	12	--	int¹		4		WA NA EA	360
rs35052005^1,2	C,	--	49654934(+)	`CATCC-/AATTTT`	12	--	int¹		0	--	--	--	--
rs78164270^1,2		--	49655062(+)	`GCTGCC/TTCCCT`	12	--	int¹		1		CSA	2
rs41422344^1,2	C,F,H,	--	49655173(+)	`AATAAG/AGTTTT`	12	--	int¹		13		NS EA NA WA	1338
rs1788028^1,2	C,	--	49655334(+)	`CCAAGT/AGGTTC`	12	--	int¹		2		WA	120
rs73488976^1,2	C,	--	49655565(+)	`TGCCCG/ACCACC`	12	--	int¹		1		WA	2
rs1788052^1,2		--	49655589(-)	`aaataA/Caaaaa`	12	--	int¹		0	--	--	--	--
rs113662542^1,2	C,	--	49655656(+)	`GTGATT/CTGCCT`	12	--	int¹		2		WA NA	122
rs72925070^1,2		--	49655989(+)	`TTTTAC/TATAAG`	12	--	int¹		0	--	--	--	--
rs57421596^1,2	C,F,	--	49656605(+)	`TTCTAC/TCCTTT`	12	--	int¹		3		WA	122
rs1787791^1,2	C,	--	49656694(-)	`TACACC/TGAGCT`	12	--	int¹		2		WA	120
rs11876095^1,2	C,F,H,	--	49657330(+)	`ACAAAT/CTCATA`	12	--	int¹		1		NA	6
rs8094490^1,2	C,	--	49657349(+)	`TTTAAC/TTTTAA`	12	--	int¹		2		WA	120
rs1787251^1,2	C,F,A,H,	--	49658253(-)	`CATTCC/TGTCAG`	12	--	int¹		10		NS EA NA WA	664
rs1788029^1,2	C,	--	49658474(+)	`TTTTAA/GTTACA`	12	--	int¹		3		NA WA	122
rs1261116^1,2	C,F,	--	49659167(+)	`TCACCA/GTTTGA`	12	--	int¹		8		NA WA	428
rs61126434^1,2	C,	--	49659181(+)	`GGTACT/ATTTTT`	12	--	int¹		3		WA NA	240
rs1261117^1,2	C,F,A,H,	--	49659274(+)	`TTAATT/CTTTCA`	12	--	int¹		17		NS EA NA WA	2138
rs61056739^1,2	C,	--	49659361(+)	`CAAAGT/CATGGG`	12	--	int¹		3		WA NA	240
rs56927536^1,2	C,	--	49659477(+)	`ATTGTT/GAAATA`	12	--	int¹		3		WA NA	240
rs58802479^1,2	C,	--	49659494(+)	`CTTTAT/CTTAAT`	12	--	int¹		2		WA	120
rs79709866^1,2	F,	--	49659809(+)	`AACTCA/GTAGGT`	12	--	int¹		1		WA	118
rs79206125^1,2		--	49660120(+)	`TTCTGC/TACTCA`	12	--	int¹		1		EA	120
rs73488983^1,2	C,	--	49660136(+)	`GAAAAA/GAAAAT`	12	--	int¹		2		WA	120
rs1261119^1,2	C,H,	--	49660667(+)	`acagaT/Gtaatc`	12	--	int¹		6		NS EA NA	422
rs1261120^1,2	C,	--	49661285(+)	`aaaaaA/CaGATA`	12	--	int¹ trp³		3		NA WA	122
rs73488987^1,2	C,	--	49661370(+)	`TGAAGG/AAATAA`	12	--	int¹		3		WA NA	240
rs79299399^1,2		--	49661540(+)	`GAAACG/ATTGTA`	12	--	int¹		1		EA	120
rs75638679^1,2		--	49661836(+)	`GCTGGG/ATTGGA`	12	--	int¹		1		NA	120
rs58751937^1,2	F,	--	49661915(+)	`GATACG/ATCCAT`	12	--	int¹		1		EA	120
rs79939930^1,2		--	49662081(+)	`CTCTGG/CAGTCT`	12	--	int¹		1		NA	120
rs78068327^1,2	F,	--	49662120(+)	`ACAATT/CCCTTG`	12	--	int¹		1		WA	118
rs1261121^1,2	C,F,H,	--	49662512(+)	`CAAAAA/CGGTCT`	12	--	int¹		12		NS EA NA WA	1468
rs73488991^1,2	C,	--	49662535(+)	`CAGTGT/CAGAGT`	12	--	int¹		3		WA NA	240
rs59199713^1,2	C,	--	49662546(+)	`CATGTT/ACATCC`	12	--	int¹		2		WA	120
rs75389844^1,2		--	49662634(+)	`GCTGTT/CGCTTT`	12	--	int¹		1		WA	118
rs77035333^1,2	C,F,	--	49663166(+)	`TTTTTT/CCAGAT`	12	--	int¹		2		WA NA	238
rs73960222^1,2	C,	--	49663368(+)	`TTCCTA/GAAGTC`	12	--	int¹		2		WA	120
rs1261122^1,2		--	49663374(+)	`AAGTCT/CTTCCT`	12	--	int¹		4		MN NA WA	306
rs1787797^1,2	F,	--	49664020(+)	`ATGACC/AAATCT`	12	--	int¹		1		WA	118
rs1262463^1,2	C,F,A,	--	49664038(+)	`ACCAGA/GATGCA`	12	--	int¹		6		NA WA	246
rs117336804^1,2	C,F,	--	49664135(+)	`NNNNGT/AATACA`	12	--	int¹		1		NA	120
rs114817244^1,2	C,F,	--	49664528(+)	`GCAAGC/TTCAGC`	12	--	int¹		1		WA	118
rs1261123^1,2	H,	--	49664733(-)	`TTTGAA/GATTTG`	12	--	int¹		5		NS EA NA	508
rs111943569^1,2		--	49664983(+)	`TATGAC/TGTCAT`	12	--	int¹		2		CSA WA	120
rs8090418^1,2	C,H,	--	49665292(+)	`tcacaC/Tagcta`	12	--	int¹		9		NS EA NA WA	664
rs75389294^1,2	F,	--	49665487(+)	`CTGTTT/ATGCCC`	12	--	int¹		1		NA	120
rs78634690^1,2		--	49666109(+)	`CCAGGA/CTCAGG`	12	--	int¹		0	--	--	--	--
rs1261124^1,2	C,H,	--	49667285(-)	`TGACAA/GACTGT`	12	--	int¹		5		NS EA WA	536
rs1261125^1,2	C,F,	--	49667439(-)	`NNNNAT/CGTAGT`	12	--	int¹		4		WA NA	242
rs9949509^1,2	C,F,	--	49667543(+)	`CAGCCA/GAAAAG`	12	--	int¹		1		WA	118
rs79052447^1,2	C,F,	--	49667858(+)	`TCAAAA/GGGACT`	12	--	int¹		2		WA NA	238
rs1261126^1,2	A,H,	--	49668786(+)	`ATATGA/CGCTAA`	12	--	int¹		5		NS EA WA	536
rs12326261^1,2	C,	--	49669057(+)	`CTTCCG/AGAATG`	12	--	int¹		2		WA	120
rs28649202^1,2	C,F,H,	--	49669516(+)	`GTTTGG/TAACTT`	12	--	int¹		8		NS NA WA	1020
rs35399017^1,2	C,	--	49669544(+)	`ATGAA-/TGTG TGTGT`	12	--	int¹		0	--	--	--	--
rs1261127^1,2		--	49669581(+)	`atgtgC/Tgtaga`	12	--	int¹		2		NA	4
rs73960223^1,2	C,	--	49671215(+)	`TTGTGG/ATTTAG`	12	--	int¹		2		WA	120
rs1660245^1,2	C,F,	--	49671232(+)	`TCCAAT/CACAAT`	12	--	int¹		4		WA NA	242
rs73488995^1,2	C,F,	--	49671618(+)	`TGCATC/TCAGAT`	12	--	int¹		3		WA	122
rs56098771^1,2	F,	--	49671675(+)	`TGTTGC/TCCAGG`	12	--	int¹		1		WA	118
rs1799407^1,2	F,	--	49672424(+)	`TATCCG/ATCTTG`	12	--	int¹		1		WA	118
rs1788033^1,2		--	49672732(+)	`ACTAGG/TTGTCC`	12	--	int¹		0	--	--	--	--
rs10502997^1,2	C,F,H,	--	49673353(+)	`TGATCG/CGGCTT`	12	--	int¹		9		NS EA	518
rs77416177^1,2	F,	--	49673360(+)	`GCTTCT/CACTAT`	12	--	int¹		1		EA	120
rs12605514^1,2	C,F,H	--	49673748(+)	`GGCTAT/ATatta`	12	--	int¹		1		NA	4
rs73960226^1,2	C,	--	49673760(+)	`GAATGG/CGTGAG`	12	--	int¹		2		WA	120
rs35268463^1,2	C	--	49673997(+)	`GAGGT-/TTTTTT`	12	--	int¹		1		NA	2
rs201353010^1,2	C	--	49674075(-)	`TCTTTC/TTTTCC`	12	--	int¹		0	--	--	--	--
rs200930922^1,2	C	--	49674318(-)	`GAGCTA/CGCTCA`	12	--	int¹		0	--	--	--	--
rs60357769^1,2	C,	--	49674826(+)	`GAATGT/CAGTAA`	12	--	int¹		2		WA	120
rs1272831^1,2	H	--	49675760(-)	`TTTATA/GATGGT`	12	--	int¹		4		NS EA	418
rs112203498^1,2	C,	--	49676208(+)	`TGAGTC/TGAGAT`	12	--	int¹		1		WA	2
rs114064603^1,2	C,F,	--	49677082(+)	`NNNNCC/ACCTAT`	12	--	int¹		2		WA NA	238
rs73488997^1,2	C,F,	--	49677249(+)	`GGCAGG/CGAATG`	12	--	int¹		1		WA	118
rs61023611^1,2	C,	--	49677846(+)	`AGAGCA/GGGGAA`	12	--	int¹		2		WA	120
rs112624970^1,2	C,	--	49678717(+)	`CAAAAC/TTCTTG`	12	--	int¹		1		NA	2
rs73960228^1,2	C,	--	49679490(+)	`ATGTCC/TGCTGT`	12	--	int¹ us2k¹		2		WA	120
rs73488999^1,2	C,	--	49680166(+)	`TTACCT/AGATGT`	12	--	int¹ us2k¹		1		WA	2
rs1261242^1,2	F,H,	--	49680196(+)	`CCTCCT/CGAAAG`	12	--	int¹ us2k¹ trp³		7		NS EA NA CSA	424
rs75595647^1,2	F,	--	49680636(+)	`AACACG/AACATG`	12	--	int¹ us2k¹		1		WA	118
rs73490803^1,2	C,	--	49680763(+)	`GAAAAC/ACTCTA`	12	--	int¹ us2k¹		3		WA NA	240
rs56057182^1,2	C,	--	49680814(+)	`AGAATC/TTCATT`	12	--	int¹ us2k¹		2		WA	120
rs77155203^1,2	F,	--	49681068(+)	`CATTTC/TATTCA`	12	--	int¹ us2k¹		1		NA	120
rs8093423^1,2	C,F,A,H,	--	49681345(+)	`TTATAT/CGAAAA`	12	--	int¹ us2k¹		10		NS NA WA	1054
rs59909085^1,2	C,	--	49682066(+)	`GGAGAA/CGGCAA`	11	--	int¹		3		WA NA	240
rs72925079^1,2	C,F,	--	49682974(+)	`TTGGGA/CANNNN`	11	--	int¹		1		WA	118
rs73490806^1,2	C,	--	49684478(+)	`GAAACC/AAAAAT`	11	--	int¹		1		WA	2
rs77585094^1,2		--	49684666(+)	`CACCAC/TAGGCT`	11	--	int¹		0	--	--	--	--
rs9959381^1,2	C,F,H,	--	49684906(+)	`CCAACG/ACTAAC`	11	--	int¹		7		NS EA NA WA	540
rs75742398^1,2	C,	--	49685939(+)	`ATCATT/CTATTT`	11	--	int¹		2		WA	120
rs1788034^1,2	H	--	49686154(-)	`tgtctC/Ttagaa`	11	--	int¹		4		NS EA	416
rs77956318^1,2	F,	--	49686160(+)	`AGACAG/AGGTGT`	11	--	int¹		1		EA	120
rs9963203^1,2	C,F,H,	--	49686378(+)	`CTGAGG/ATGCAG`	11	--	int¹		6		NS EA WA NA	656
rs9959439^1,2	C,F,H,	--	49686976(+)	`TGTGAT/CGTACA`	11	--	int¹		15		NS EA NA WA	1966
rs72925081^1,2	C,F,	--	49687669(+)	`TCTTTC/TCACTT`	11	--	int¹		1		NA	120
rs57244653^1,2	C,	--	49687683(+)	`GTCCTG/ATAGGG`	11	--	int¹		3		WA NA	240
rs79642966^1,2	C,F,	--	49687922(+)	`TAAAAC/TGTAGA`	11	--	int¹		1		WA	118
rs1440474^1,2	C,F,	--	49688654(+)	`ACATGC/GAATAA`	11	--	int¹		1		NA	120
rs113300555^1,2		--	49688803(+)	`ATACAC/TTCATC`	11	--	int¹		1		CSA	2
rs118023140^1,2	C,F,	--	49688863(+)	`NNNNCT/CAGGAC`	11	--	int¹		1		NA	120
rs1440475^1,2	C,F,H,	--	49688966(+)	`ATATTT/GTATAT`	11	--	int¹		14		NS EA NA WA	1964
rs28604337^1,2	C,F,	--	49689088(+)	`TAATAC/TGGATT`	11	--	int¹		2		WA NA	238
rs112342025^1,2		--	49689234(+)	`GCTACT/ATAGCC`	11	--	int¹		1		CSA	2
rs1153639^1,2		--	49689260(-)	`CAGATA/GAGAAA`	11	--	int¹		0	--	--	--	--
rs1153640^1,2		--	49689329(+)	`CCTTCA/GTAAGA`	11	--	int¹		0	--	--	--	--
rs80214307^1,2		--	49689478(+)	`TGATTA/TTATCA`	11	--	int¹		0	--	--	--	--
rs76137950^1,2		--	49690022(+)	`TCCTAT/CGGCAA`	11	--	int¹		1		WA	118
rs73490810^1,2	C,F,	--	49690475(+)	`CTCTGT/CGTGAA`	11	--	int¹		3		WA CSA	122
rs9952730^1,2	C,F,A,H,	--	49691315(+)	`ATCACA/GTCAGT`	11	--	int¹		15		NS EA NA WA	1966
rs78678983^1,2	F,	--	49692871(+)	`GCTAAT/CAAAGT`	11	--	int¹		1		WA	118
rs10502998^1,2	C,F,H,	--	49694597(+)	`CCCAAT/ATGAGA`	11	--	int¹		22		NS EA NA WA	1828
rs73490813^1,2	C,	--	49695018(+)	`ATCTTC/AGTGGA`	11	--	int¹		3		WA NA	240
rs9320008^1,2	C,F,H,	--	49695390(+)	`TGAAAC/GTCTCA`	11	--	int¹		13		NS EA NA WA	764
rs79050903^1,2	F,	--	49696073(+)	`TCTTCG/AATAGG`	11	--	int¹		2		NA EA	240
rs111889427^1,2	C,	--	49696289(+)	`TGTCTG/CTTTCA`	11	--	int¹		1		NA	2
rs73960232^1,2	C,	--	49696613(+)	`TCTTAC/TGGTGG`	11	--	int¹		2		WA	120

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TCF4 Gene

transcription factor 4

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for TCF4 gene

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for TCF4 gene

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for TCF4 gene

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Export list of displayed genes

TCF4 Gene

transcription factor 4

Aliasesfor TCF4 gene

Summariesfor TCF4 gene

Genomic Viewsfor TCF4 gene

Proteinsfor TCF4 gene

Protein Domains /Familiesfor TCF4 gene

Functionfor TCF4 gene

Pathways & Interactionsfor TCF4 gene

Drugs & Compoundsfor TCF4 gene

Transcriptsfor TCF4 gene

Expression for TCF4 gene

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for TCF4 gene

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for TCF4 gene

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for TCF4 gene

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for TCF4 gene

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for TCF4 gene

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for TCF4 gene

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for TCF4 gene

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for TCF4 gene

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for TCF4 gene

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for TCF4 gene

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for TCF4 gene

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for TCF4 gene