Aliases for TCF4 Gene
Aliases for TCF4 Gene
External Ids for TCF4 Gene
- HGNC: 11634
- Entrez Gene: 6925
- Ensembl: ENSG00000196628
- OMIM: 602272
- UniProtKB: P15884
Previous GeneCards Identifiers for TCF4 Gene
- GC18M052983
- GC18M052797
- GC18M052679
- GC18M051043
- GC18M051045
- GC18M052889
- GC18M049599
Summaries for TCF4 Gene
-
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]
GeneCards Summary for TCF4 Gene
TCF4 (Transcription Factor 4) is a Protein Coding gene. Diseases associated with TCF4 include Pitt-Hopkins Syndrome and Corneal Dystrophy, Fuchs Endothelial, 3. Among its related pathways are PAK Pathway and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is TCF12.
UniProtKB/Swiss-Prot for TCF4 Gene
-
Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5-ACANNTGT-3 or 5-CCANNTGG-3.
Additional gene information for TCF4 Gene
- Monarch Initiative
- Search for TCF4 at DataMed
- Search for TCF4 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF4 Gene
Genomics for TCF4 Gene
GeneHancer (GH) Regulatory Elements for TCF4 Gene
Regulatory Element Products
Genomic Locations for TCF4 Gene
- chr18:55,222,331-55,664,787
- (GRCh38/hg38)
- Size:
- 442,457 bases
- Orientation:
- Minus strand
- chr18:52,889,562-53,332,018
- (GRCh37/hg19)
Genomic View for TCF4 Gene
- Cytogenetic band:
-
- 18q21.2 by Ensembl
- 18q21.2 by Entrez Gene
- 18q21.2 by HGNC


RefSeq DNA sequence for TCF4 Gene
Proteins for TCF4 Gene
-
Protein details for TCF4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15884-ITF2_HUMAN
- Recommended name:
- Transcription factor 4
- Protein Accession:
- P15884
- B3KT62
- B3KUC0
- B4DT37
- B4DUG3
- B7Z5M6
- B7Z6Y1
- G0LNT9
- G0LNU0
- G0LNU1
- G0LNU2
- G0LNU4
- G0LNU5
- G0LNU8
- G0LNU9
- G0LNV0
- G0LNV1
- G0LNV2
- H3BPQ1
- Q08AP2
- Q08AP3
- Q15439
- Q15440
- Q15441
Protein attributes for TCF4 Gene
- Size:
- 667 amino acids
- Molecular mass:
- 71308 Da
- Quaternary structure:
-
- Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin. Interacts with HIVEP2. Interacts with NEUROD2 (By similarity). Interacts with AGBL1. Interacts with BHLHA9.
- SequenceCaution:
-
- Sequence=AAA60310.1; Type=Miscellaneous discrepancy; Note=Incomplete and probable erroneous sequence.; Evidence={ECO:0000305}; Sequence=AAA60312.1; Type=Miscellaneous discrepancy; Note=Incomplete and probable erroneous sequence.; Evidence={ECO:0000305};
Protein Expression for TCF4 Gene
Post-translational modifications for TCF4 Gene
Other Protein References for TCF4 Gene
- ENSEMBL proteins:
-
- ENSP00000348374
- ENSP00000381382
- ENSP00000409447
- ENSP00000439656
- ENSP00000439827
- ENSP00000440731
- ENSP00000441562
- ENSP00000445202
- ENSP00000454328
- ENSP00000454352
- ENSP00000454366
- ENSP00000454441
- ENSP00000454584
- ENSP00000454647
- ENSP00000454866
- ENSP00000455071
- ENSP00000455135
- ENSP00000455163
- ENSP00000455179
- ENSP00000455261
- ENSP00000455304
- ENSP00000455346
- ENSP00000455418
- ENSP00000455450
- ENSP00000455763
- ENSP00000455984
- ENSP00000456125
- ENSP00000456220
- ENSP00000456802
- ENSP00000456983
- ENSP00000457082
- ENSP00000457113
- ENSP00000457245
- ENSP00000457263
- ENSP00000457392
- ENSP00000457649
- ENSP00000457747
- ENSP00000457765
- ENSP00000458122
- ENSP00000468277
- ENSP00000468729
- ENSP00000478549
- ENSP00000485755
- ENSP00000486072
- ENSP00000486111
- ENSP00000486148
- ENSP00000486215
- ENSP00000486405
- ENSP00000486670
- ENSP00000486909
- ENSP00000486974
- ENSP00000487010
- ENSP00000487134
- ENSP00000487150
- ENSP00000487171
- ENSP00000487218
- ENSP00000487413
- ENSP00000487415
- ENSP00000487419
- ENSP00000487505
- ENSP00000487557
- ENSP00000489783
- ENSP00000489916
- ENSP00000490006
- ENSP00000490234
- ENSP00000490329
- ENSP00000490451
- ENSP00000490625
- ENSP00000490832
- ENSP00000490883
- ENSP00000346440
- REFSEQ proteins:
-
- NP_001077431.1
- NP_001230155.2
- NP_001230156.1
- NP_001230157.1
- NP_001230159.1
- NP_001230160.1
- NP_001230161.1
- NP_001230162.1
- NP_001230163.1
- NP_001230164.1
- NP_001230165.1
- NP_001293136.1
- NP_001293137.1
- NP_001317533.1
- NP_001317534.1
- NP_001335140.1
- NP_001335141.1
- NP_001335142.1
- NP_001335143.1
- NP_001335144.1
- NP_001335145.1
- NP_001335146.1
- NP_001335147.1
- NP_001335148.1
- NP_001335149.1
- NP_003190.1
- XP_005266796.2
- XP_005266798.1
- XP_005266800.1
- XP_005266801.1
- XP_005266802.1
- XP_005266804.1
- XP_005266806.1
- XP_005266809.1
- XP_005266811.1
- XP_005266812.1
- XP_005266818.1
- XP_006722599.1
- XP_006722600.1
- XP_006722601.1
- XP_011524460.1
- XP_011524462.1
- XP_016881423.1
- XP_016881424.1
- XP_016881425.1
- XP_016881426.1
- XP_016881427.1
- XP_016881428.1
- XP_016881429.1
- XP_016881430.1
- XP_016881431.1
- XP_016881432.1
- XP_016881433.1
- XP_016881434.1
- XP_016881435.1
- XP_016881436.1
- XP_016881437.1
- XP_016881438.1
- XP_016881439.1
- XP_016881440.1
- XP_016881441.1
- XP_016881442.1
- XP_016881443.1
- XP_016881444.1
- XP_016881445.1
- XP_016881446.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TCF4
- Novus Biologicals Antibodies for TCF4
-
Abcam antibodies for TCF4
- Invitrogen Antibodies for TCF4
- Search GeneTex for Antibodies for TCF4
-
Santa Cruz Biotechnology (SCBT) Antibodies for TCF4
Protein Products
-
OriGene Purified Proteins for TCF4
- Search Origene for MassSpec and Protein Over-expression Lysates for TCF4
- Origene Custom Protein Services for TCF4
- ProSpec Recombinant Proteins for TCF4
- Search GeneTex for Proteins for TCF4
-
Abcam proteins for TCF4
Assay Products
No data available for DME Specific Peptides for TCF4 Gene
Domains & Families for TCF4 Gene
Gene Families for TCF4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for TCF4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TCF4 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ37722 fis, clone BRHIP2019186, highly similar to TRANSCRIPTION FACTOR 4 (B3KT62_HUMAN)
- cDNA FLJ39543 fis, clone PUAEN2008939, highly similar to TRANSCRIPTION FACTOR 4 (B3KUC0_HUMAN)
- cDNA, FLJ79064, highly similar to Transcription factor 4 (B4DUG3_HUMAN)
- cDNA FLJ58684, highly similar to Transcription factor 4 (B7Z5M6_HUMAN)
- cDNA FLJ58695, highly similar to Transcription factor 4 (B7Z6Y1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P15884UniProtKB/Swiss-Prot:
ITF2_HUMAN :- the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
- Domain:
-
- the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Function for TCF4 Gene
Molecular function for TCF4 Gene
- GENATLAS Biochemistry:
- transcription factor 4,with several alternatively spliced isoforms
- UniProtKB/Swiss-Prot Function:
- Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5-ACANNTGT-3 or 5-CCANNTGG-3.
Phenotypes From GWAS Catalog for TCF4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | ISS,IDA | 8978694 |
GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting | ISS | 8978694 |
GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | ISS | 8978694 |
GO:0001087 | transcription factor activity, TFIIB-class binding | ISS | 8978694 |
GO:0001093 | TFIIB-class transcription factor binding | ISS | 8978694 |
Phenotypes for TCF4 Gene
- MGI mutant phenotypes for TCF4:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for TCF4:
-
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Wnt reporter downregulated
- Decreased shRNA abundance
- Increased cell death HMECs cells
- Increased viability with TRAIL
Animal Models for TCF4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TCF4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TCF4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TCF4 gene
- Search ViGene Biosciences for TCF4
CRISPR Products
-
OriGene CRISPR knockouts for TCF4
- genomics-online: gRNA clones - Search results for 164 available TCF4 gene related products
- Overview of 164 available TCF4 gene related products
- Applied Biological Materials CRISPR for TCF4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TCF4
- GenScript: Design CRISPR guide RNA sequences for TCF4
miRNA for TCF4 Gene
- miRTarBase miRNAs that target TCF4
-
- hsa-mir-204-5p (MIRT005846)
- hsa-mir-130b-3p (MIRT020336)
- hsa-mir-19b-3p (MIRT031229)
- hsa-let-7e-5p (MIRT051694)
- hsa-mir-203a-3p (MIRT053443)
- hsa-mir-452-5p (MIRT437782)
- hsa-mir-126-3p (MIRT438192)
- hsa-mir-20a-5p (MIRT439478)
- hsa-mir-106b-5p (MIRT439479)
- hsa-mir-155-5p (MIRT439480)
- hsa-mir-519d-3p (MIRT726342)
- hsa-mir-93-5p (MIRT726343)
- hsa-mir-20b-5p (MIRT726344)
- hsa-mir-17-5p (MIRT726345)
- hsa-mir-181a-5p (MIRT733917)
Transcription Factor Targets for TCF4 Gene
miRNA Products
- Search ViGene Biosciences for TCF4
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for TCF4
- Browse OriGene Inhibitory RNA Products For TCF4
- genomics-online: shRNA clones - Search results for 164 available TCF4 gene related products
- Overview of 164 available TCF4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TCF4 gene
Clone Products
-
OriGene ORF clones in human for TCF4
- RG217718
- RC217718L2
- RC217718L1
- RC217718
- RG232888
- RC232888
- RG232887
- RC232887
- RG232892
- RC232892
- RG232948
- RC232948
- RG233001
- RC233001
- RG233023
- RC233023
- RG233064
- RC233064
- RG233072
- RC233072
- RG233055
- RC233055
- RG233129
- RC233129
- RG224345
- RC224345L2
- RC224345L1
- RC224345
- RC217718L2V
- RC217718L1V
- RC224345L2V
- RC224345L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for TCF4 in any vector
- NM_001243227.1
- XM_005266749.3
- NM_001243234.1
- XM_006722538.2
- NM_001243228.1
- XM_011526158.1
- XM_011526164.1
- XM_006722536.2
- XM_006722539.2
- NM_001083962.1
- NM_001306207.1
- XM_005266752.3
- NM_001243231.1
- XM_005266755.3
- XM_011526156.1
- NM_001306208.1
- XM_005266754.3
- XM_011526155.1
- NM_001243235.1
- XM_011526161.1
- XM_005266739.3
- XM_011526163.1
- XM_005266741.3
- XM_005266761.3
- XM_005266744.3
- NM_001243230.1
- XM_005266747.3
- NM_003199.2
- NM_001243232.1
- XM_011526159.1
- XM_011526154.1
- NM_001243236.1
- XM_011526160.1
- XM_011526157.1
- NM_001243226.2
- XM_011526162.1
- XM_006722537.2
- XM_006722540.2
- XM_005266743.3
- NM_001243233.1
- XM_005266745.3
- Sino Biological Human cDNA Clone for TCF4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TCF4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TCF4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TCF4
- Applied Biological Materials Clones for TCF4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TCF4
-
ViGene Biosciences adenoviral particle packaged cDNA for TCF4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TCF4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TCF4 gene
No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for TCF4 Gene
Localization for TCF4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TCF4 Gene
- Nucleus.
- Nucleoplasm (3)
- Cytosol (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | IDA | 21880741 |
GO:0005634 | nucleus | IEA,IDA | 1681116 |
GO:0005667 | transcription factor complex | ISS | 8978694 |
GO:0032993 | protein-DNA complex | IDA | -- |
GO:0070369 | beta-catenin-TCF7L2 complex | IDA | 12651860 |
Pathways & Interactions for TCF4 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | ERK Signaling |
.58
|
.49
|
2 | Human Embryonic Stem Cell Pluripotency | ||
3 | Myogenesis |
1.00
|
1.00
|
4 | Mesodermal Commitment Pathway | ||
5 | CDK-mediated phosphorylation and removal of Cdc6 |
Pathways by source for TCF4 Gene
2 Sino Biological pathways for TCF4 Gene
3 Reactome pathways for TCF4 Gene
Interacting Proteins for TCF4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006352 | DNA-templated transcription, initiation | ISS | 8978694 |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006367 | transcription initiation from RNA polymerase II promoter | ISS | 8978694 |
GO:0007399 | nervous system development | IEA | -- |
Transcripts for TCF4 Gene
mRNA/cDNA for TCF4 Gene
- (66) REFSEQ mRNAs :
- (41) Additional mRNA sequences :
- (512) Selected AceView cDNA sequences:
- (90) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TCF4 Gene
- Transcription factor 4:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for TCF4
- genomics-online: gRNA clones - Search results for 164 available TCF4 gene related products
- Overview of 164 available TCF4 gene related products
- Applied Biological Materials CRISPR for TCF4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TCF4
- GenScript: Design CRISPR guide RNA sequences for TCF4
miRNA Products
- Search ViGene Biosciences for TCF4
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for TCF4
- Browse OriGene Inhibitory RNA Products For TCF4
- genomics-online: shRNA clones - Search results for 164 available TCF4 gene related products
- Overview of 164 available TCF4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TCF4 gene
Clone Products
-
OriGene ORF clones in human for TCF4
- RG217718
- RC217718L2
- RC217718L1
- RC217718
- RG232888
- RC232888
- RG232887
- RC232887
- RG232892
- RC232892
- RG232948
- RC232948
- RG233001
- RC233001
- RG233023
- RC233023
- RG233064
- RC233064
- RG233072
- RC233072
- RG233055
- RC233055
- RG233129
- RC233129
- RG224345
- RC224345L2
- RC224345L1
- RC224345
- RC217718L2V
- RC217718L1V
- RC224345L2V
- RC224345L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for TCF4 in any vector
- NM_001243227.1
- XM_005266749.3
- NM_001243234.1
- XM_006722538.2
- NM_001243228.1
- XM_011526158.1
- XM_011526164.1
- XM_006722536.2
- XM_006722539.2
- NM_001083962.1
- NM_001306207.1
- XM_005266752.3
- NM_001243231.1
- XM_005266755.3
- XM_011526156.1
- NM_001306208.1
- XM_005266754.3
- XM_011526155.1
- NM_001243235.1
- XM_011526161.1
- XM_005266739.3
- XM_011526163.1
- XM_005266741.3
- XM_005266761.3
- XM_005266744.3
- NM_001243230.1
- XM_005266747.3
- NM_003199.2
- NM_001243232.1
- XM_011526159.1
- XM_011526154.1
- NM_001243236.1
- XM_011526160.1
- XM_011526157.1
- NM_001243226.2
- XM_011526162.1
- XM_006722537.2
- XM_006722540.2
- XM_005266743.3
- NM_001243233.1
- XM_005266745.3
- Sino Biological Human cDNA Clone for TCF4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TCF4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TCF4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TCF4
- Applied Biological Materials Clones for TCF4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 22b | ^ | 23 | ^ | 24a | · | 24b | · | 24c | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||
SP2: | - | ||||||||||||||||||
SP3: | - | - | |||||||||||||||||
SP4: | - | ||||||||||||||||||
SP5: | |||||||||||||||||||
SP6: | |||||||||||||||||||
SP7: | |||||||||||||||||||
SP8: | |||||||||||||||||||
SP9: | |||||||||||||||||||
SP10: | |||||||||||||||||||
SP11: | |||||||||||||||||||
SP12: | |||||||||||||||||||
SP13: |
Expression for TCF4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- pre Conventional Dendritic Cells Peripheral Blood
- Plasmacytoid Dendritic cells Peripheral Blood
- Mature B-Cells Peripheral Blood
- Peripheral blood-derived hematopoietic stem cells (family)
- Peripheral blood-derived hematopoietic stem cells
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
- nGnG Amacrine Cells Inner Nuclear Layer
- Limbal Basal Epithelial Cells Limbus Epithelium
- AII Amacrine Cells Inner Nuclear Layer
- Neural Tube (Nervous System)
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
- nGnG Amacrine Cells Inner Nuclear Layer
- AII Amacrine Cells Inner Nuclear Layer
-
Dermis (Integumentary System)
- Dermal Mesenchyme Cells Ventral Subectodermal Mesenchyme
-
Epithelial Cells
- Limbal Basal Epithelial Cells Limbus Epithelium
-
Head Mesenchyme (Muscoskeletal System)
- Cranial Tendons Cells Branchial Arch 1
-
Tendon amp Ligament
- Cranial Tendons Cells Branchial Arch 1
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
- Epidermis (Integumentary System)
- Hair
-
Bone (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCF4 Gene
NURSA nuclear receptor signaling pathways regulating expression of TCF4 Gene:
TCF4SOURCE GeneReport for Unigene cluster for TCF4 Gene:
Hs.605153mRNA Expression by UniProt/SwissProt for TCF4 Gene:
P15884-ITF2_HUMANEvidence on tissue expression from TISSUES for TCF4 Gene
- Nervous system(5)
- Bone(4.9)
- Spleen(4.6)
- Blood(4.4)
- Skin(4.4)
- Lung(3.5)
- Eye(2.7)
- Kidney(2.7)
- Lymph node(2.4)
- Muscle(2.4)
- Heart(2.2)
- Intestine(2.2)
- Thyroid gland(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF4 Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
- brain
- cerebellum
- cheek
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- pharynx
- skull
- tooth
- chest wall
- diaphragm
- esophagus
- heart
- lung
- abdominal wall
- biliary tract
- gallbladder
- intestine
- kidney
- large intestine
- liver
- pancreas
- stomach
- penis
- rectum
- testicle
- ureter
- urinary bladder
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
- blood
- blood vessel
- hair
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- spinal cord
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for TCF4
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for TCF4 Gene
Orthologs for TCF4 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TCF4 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | TCF7L2 34 |
|
OneToOne | |
TCF4 33 |
|
||||
oppossum (Monodelphis domestica) |
Mammalia | TCF4 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | TCF4 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | TCF4 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Tcf4 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Tcf4 33 |
|
||
chicken (Gallus gallus) |
Aves | TCF4 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | TCF4 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | tcf4 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | CABZ01109624.1 34 |
|
OneToMany | |
tcf4 34 |
|
OneToMany | |||
fruit fly (Drosophila melanogaster) |
Insecta | da 35 34 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | hlh-2 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for TCF4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TCF4 Gene
(85) SIMAP similar genes for TCF4 Gene using alignment to 31 proteins:
- ITF2_HUMAN
- E9PH57_HUMAN
- G0LNT1_HUMAN
- G0LNT2_HUMAN
- G0LNT3_HUMAN
- G0LNT4_HUMAN
- G0LNT5_HUMAN
- G0LNT6_HUMAN
- G0LNT7_HUMAN
- G0LNT8_HUMAN
- G0LNU4_HUMAN
- G0LNV2_HUMAN
- H3BMC8_HUMAN
- H3BME8_HUMAN
- H3BML7_HUMAN
- H3BNI2_HUMAN
- H3BNZ2_HUMAN
- H3BP59_HUMAN
- H3BPG3_HUMAN
- H3BPJ7_HUMAN
- H3BRF7_HUMAN
- H3BSX3_HUMAN
- H3BT24_HUMAN
- H3BT95_HUMAN
- H3BTC3_HUMAN
- H3BTM9_HUMAN
- H3BTP3_HUMAN
- H3BTZ0_HUMAN
- H3BUQ3_HUMAN
- K7ERJ0_HUMAN
- K7ESI6_HUMAN
- EML2
- HOOK2
- VPS33A
- ZNF814
- CRCP
- ZNF546
- DCTN5
- DNAPTP3
- TCF12
- UBIAD1
- SH3PXD2A
- ZNF212
- C4orf21
- ZNF527
- ZNF283
- LAMB4
- PLEKHH2
- TMEM14B
- PHC3
- ERBB2
- BTBD2
- APOPT1
- LYRM4
- ZNF738
- ZNF585B
- EDRF1
- ATP6V0A1
- RBMS2
- HKR1
- FAM129C
- NRAMP1
- ATR
- ZNF611
- NPLOC4
- ZNF547
- ZNF737
- ZNF100
- TNFRSF17
- MPP4
- FKBP3
- FAM210A
- DNMT1
- SPATS2L
- FAM175A
- ZNF564
- NSRP1
- ZNF763
- ZNF675
- TIMM23B
- MEFV
- CLUL1
- AEBP2
- USP10
- AURA2
- SNX31
- PKN1
- DAPL1
- RNF217
- ZNF468
- TCF3
- ZNF20
- SPAG11B
- SPAG11A
- NUP88
- SHANK2
- NF2
- ZNF28
- APOD
- MVK
- ZNF461
- BECN1
- ZNF816
- CHID1
- GLT8D2
- KDM5B
- ZNF195
- ASB11
- ZNF83
- WARS
- CATSPERG
- GCDH
- LEPROTL1
- FAT3
- C2CD4A
- RBBP4
Variants for TCF4 Gene
SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1003259439 | uncertain-significance, Pitt-Hopkins syndrome | 55,225,470(-) | A/G/T | 3_prime_UTR_variant | |
rs1014557607 | uncertain-significance, Pitt-Hopkins syndrome | 55,222,652(-) | A/G | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
rs1026555929 | uncertain-significance, Pitt-Hopkins syndrome | 55,226,123(-) | T/A/C | 3_prime_UTR_variant | |
rs1057518848 | pathogenic, Cerebral hypoplasia, Global developmental delay | 55,229,004(-) | ATTG/ATTGATTG | coding_sequence_variant, frameshift | |
rs1057518864 | pathogenic, Anteverted nares, Drooling, Epicanthus, Feeding difficulties in infancy, Global developmental delay, Short nose, Stereotypy | 55,350,409(-) | C/T | genic_upstream_transcript_variant, splice_acceptor_variant |
Additional Variant Information for TCF4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF4 Gene
Disorders for TCF4 Gene

(14) MalaCards diseases for TCF4 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
pitt-hopkins syndrome |
|
|
corneal dystrophy, fuchs endothelial, 3 |
|
|
epicanthus |
|
|
fuchs' endothelial dystrophy |
|
|
alacrima, achalasia, and mental retardation syndrome |
|
|
UniProtKB/Swiss-Prot
ITF2_HUMAN- Corneal dystrophy, Fuchs endothelial, 3 (FECD3) [MIM:613267]: A late-onset form of Fuchs endothelial corneal dystrophy, a disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition. {ECO:0000269 PubMed:24255041, ECO:0000269 PubMed:25168903, ECO:0000269 PubMed:25593321}. Note=The disease is caused by mutations affecting the gene represented in this entry. Causative mutations are heterozygous TCF4 intronic trinucleotide repeat expansions (CTG)n. {ECO:0000269 PubMed:24255041, ECO:0000269 PubMed:25168903, ECO:0000269 PubMed:25593321}.
- Note=Defects in TCF4 may cause autosomal dominant symmetrical acral keratoderma (SAK)syndrome. Symmetrical acral keratodermadefines is characterized by brown/black hyperkeratotic patches symmetrically distributed on the acral regions, especially the wrists, ankles, dorsa of hands, fingers and feet affects young and middle aged men. Patients have epidermis thickened by acanthosis and compact stratum corneum(PubMed:28921696). {ECO:0000269 PubMed:28921696}.
- Pitt-Hopkins syndrome (PTHS) [MIM:610954]: A syndrome characterized by mental retardation, wide mouth and distinctive facial features, and intermittent hyperventilation followed by apnea. Features include intellectual disability with severe speech impairment, normal growth parameters at birth, postnatal microcephaly, breathing anomalies, severe motor developmental delay, motor incoordination, ocular anomalies, constipation, seizures, typical behavior and subtle brain abnormalities. {ECO:0000269 PubMed:17436254, ECO:0000269 PubMed:17436255, ECO:0000269 PubMed:18728071, ECO:0000269 PubMed:19235238, ECO:0000269 PubMed:20184619, ECO:0000269 PubMed:22045651, ECO:0000269 PubMed:22777675, ECO:0000269 PubMed:25356899}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for TCF4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for TCF4 Gene
Publications for TCF4 Gene
- Common variants conferring risk of schizophrenia. (PMID: 19571808) Stefansson H … Collier DA (Nature 2009) 3 22 44 58
- A novel, heritable, expanding CTG repeat in an intron of the SEF2-1 gene on chromosome 18q21.1. (PMID: 9302263) Breschel TS … Ross CA (Human molecular genetics 1997) 2 3 4 58
- Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers. (PMID: 1681116) Corneliussen B … Grundström T (Journal of virology 1991) 3 4 22 58
- Sequence of the cDNA encoding ITF-2, a positive-acting transcription factor. (PMID: 2308860) Henthorn P … Kadesch T (Nucleic acids research 1990) 2 3 4 58
- Association and familial segregation of CTG18.1 trinucleotide repeat expansion of TCF4 gene in Fuchs' endothelial corneal dystrophy. (PMID: 24255041) Mootha VV … Xing C (Investigative ophthalmology & visual science 2014) 3 4 58
Products for TCF4 Gene
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- RC224345L1V
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- RC224345
- RC224345L1
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- RG224345
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- RG232887
- RC232888
- RG232888
- RC217718
- RC217718L1
- RC217718L2
- RG217718
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- XM_005266745.3
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- NM_001243226.2
- XM_011526157.1
- XM_011526160.1
- NM_001243236.1
- XM_011526154.1
- XM_011526159.1
- NM_001243232.1
- NM_003199.2
- XM_005266747.3
- NM_001243230.1
- XM_005266744.3
- XM_005266761.3
- XM_005266741.3
- XM_011526163.1
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- NM_001243228.1
- XM_011526158.1
- XM_011526164.1
- XM_006722536.2
- XM_006722539.2
- NM_001306208.1
- XM_011526156.1
- XM_005266755.3
- NM_001243231.1
- XM_005266752.3
- NM_001306207.1
- NM_001083962.1
- GenScript Custom Purified and Recombinant Proteins Services for TCF4
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- Invitrogen Antibodies for TCF4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TCF4
- antibodies-online: Search results for 86 available TCF4 Antibodies ranked by validation data
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- ViGene Biosciences adenoviral particle packaged cDNA for TCF4 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for TCF4
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- genomics-online: cdna clones - Search results for 164 available TCF4 gene related products
- Overview of 164 available TCF4 gene related products
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- Overview of 164 available TCF4 gene related products
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- Overview of 164 available TCF4 gene related products
Sources for TCF4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
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- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
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- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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- (92) COMPARTMENTS
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- (97) antibodies-online
- (98) CYP
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- (140) SNPedia
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- (147) Gene ORGANizer
- (148) abm
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- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew