TCF4 Gene

Aliases
for TCF4 gene

Previous GC identifers: GC18M052983 GC18M052797 GC18M052679 GC18M051043 GC18M051045 GC18M049599

Summaries
for TCF4 gene

Genomic Views
for TCF4 gene

RefSeq DNA sequence:

NC_000018.9  NC_018929.1  NT_025028.14  

SwitchGear Promoter luciferase reporter plasmid: TCF4 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF4

TCF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M052889:  view genomic region     (about GC identifiers)

Proteins
for TCF4 gene

1 PDB 3D structure from and Proteopedia for TCF4:

2KWF (3D)    

Explore the universe of human proteins at neXtProt for TCF4: NX_P15884

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): TCF4 OriGene Protein Over-expression Lysate (see all 2): TCF4 OriGene Custom Protein Services for TCF4
	GenScript Custom Purified and Recombinant Proteins Services for TCF4
	Novus Biologicals TCF4 Protein Novus Biologicals TCF4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TCF4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Browse OriGene Antibodies OriGene Custom Antibody Services for TCF4
	GenScript Custom Superior Antibodies Services for TCF4
	Novus Biologicals TCF4 Antibodies
	Search for Antibodies for TCF4 at Abcam
	Uscn Antibodies for TCF4
	ThermoFisher Antibodies for TCF4

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TCF4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TCF4

Protein Domains /
Families
for TCF4 gene

ProtoNet protein and cluster: P15884

Function
for TCF4 gene

		10/578 SABiosciences Target genes for TCF4 (see all 578):
		AASDH ABCA7 ACR ACTBL2 AFAP1L1 AGAP4 AGAP7 AGAP8 AGBL3 AGBL4

miRNA Products:		miRTarBase miRNAs that target TCF4: hsa-mir-204 (MIRT005846)
		OriGene 3'-UTR Clone (see all 2): TCF4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCF4
		8/187 QIAGEN miScript miRNA Assays for microRNAs that regulate TCF4 (see all 187):
		hsa-miR-193a-3p hsa-miR-106a hsa-miR-4305 hsa-miR-605 hsa-miR-128 hsa-miR-138-2* hsa-miR-519a hsa-miR-200b
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCF4 (see all 7) OriGene shRNA RFP: TCF4 OriGene siRNA: TCF4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCF4

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TCF4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCF4 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCF4 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TCF4 (NM_001083962)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCF4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TCF4
		Search LifeMap BioReagents cell lines for TCF4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF4

Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

(inferred from 4 alleles) (MGI details for Tcf4)

Pathways & Interactions
for TCF4 gene

	Super-pathway	contained gene-specific pathways
1	Rho Family GTPases	Molecular Mechanisms of Cancer 0.51 ILK Signaling 0.45 MAPK Signaling 0.51
2	Human Embryonic Stem Cell Pluripotency	Human Embryonic Stem Cell Pluripotency 1.00 Factors Promoting Cardiogenesis in Vertebrates 0.50
3	Activation of p38 alpha/beta MAPK	CDO in myogenesis 0.55 Myogenesis 0.55
4	Selected targets of Oct-3/4	Selected targets of Oct-3/4 1.00
5	Neural Crest Differentiation	Neural Crest Differentiation 1.00

1 EMD Millipore Pathway for TCF4

Selected targets of Oct-3/4

5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCF4

	MAPK Signaling
	Factors Promoting Cardiogenesis in Vertebrates
	Molecular Mechanisms of Cancer
	Colorectal Cancer Metastasis
	Glioblastoma Multiforme

4 BioSystems Pathways for TCF4

	Neural Crest Differentiation
	Wnt Signaling Pathway NetPath
	Regulation of Wnt-mediated beta catenin signaling and target gene transcription
	Coregulation of Androgen receptor activity

3        Reactome Pathways for TCF4

	Developmental Biology
	Myogenesis
	CDO in myogenesis

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

Drugs & Compounds
for TCF4 gene

Transcripts
for TCF4 gene

Expression
for TCF4 gene

TCF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGACAGATGT

3 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Head MesenchymeBranchial Arch 1Cranial Tendons Cells			Tendons & Ligaments
	LimbLimb BudLimb Bud Mesenchyme Cells			Mesoderm
	EyeInner Nuclear LayerAII Amacrine Cells			Amacrine, Retina
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCF4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TCF4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCF4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCF4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF4

Orthologs
for TCF4 gene

Paralogs
for TCF4 gene

Paralogs for TCF4 gene

TCF12²  TCF3²  

18/69 SIMAP similar genes for TCF4 using alignment to 34 protein entries:     ITF2_HUMAN (see all proteins) (see all similar genes):

EML2    HOOK2    VPS33A    CRCP    NXPE2    DCTN5

DNAPTP3    TCF12    SH3PXD2A    ZNF212    C4orf21    LAMB4

ZNF283    ZNF527    PLEKHH2    APOPT1    BTBD2    ERBB2

TCF4 for paralogs           About GeneDecksing

Genomic Variants
for TCF4 gene

10/5628 NCBI SNPs in TCF4 are shown (see all 5628)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs750908421,2	F,	--	49599560(+)	CTACCG/ACGGGC	12	--	ut31		1		EA	120
rs12610831,2		--	49600217(-)	AAACAT/CACAAA	12	--	ut31		1		MN	184
rs782481091,2		--	49600308(+)	ATATGA/GACAAT	12	--	ut31		0	--	--	--	--
rs1166139241,2	C,F,	--	49600399(+)	TTCATC/TGAATA	12	--	ut31		1		WA	118
rs615248341,2		--	49600492(+)	GGACAC/GTTCTA	12	--	ut31		0	--	--	--	--
rs1113024181,2		--	49601532(+)	CAAATT/AAAAAA	12	--	ut31		1		CSA	2
rs766400611,2	C,F,	--	49601978(+)	TTTTTT/CTCTTT	12	--	ut31		1		NA	120
rs2014469351,2	C	--	49603787(+)	TTAAAC/TCNNNN	12	--	ut31		0	--	--	--	--
rs2003230491,2	C	--	49603789(-)	GGCTGG/TGATTT	12	--	ut31		0	--	--	--	--
rs17994101,2	C	--	49604123(+)	CAGGGA/GAAGGG	12	--	ut31		2		MN NA	186

HapMap Linkage Disequilibrium report for TCF4 (52889562 - 53139562 bp, first 250kb of TCF4)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TCF4
     3 CNVs: 102673 1980 102672
Human Gene Mutation Database (HGMD): TCF4

Locus Specific Mutation Databases (LSDB): TCF4

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCF4

DNA2.0 Custom Variant and Variant Library Synthesis for TCF4

Disorders / Diseases
for TCF4 gene

20/47 diseases for TCF4

10/14 Novoseek disease relationships for TCF4 gene (see all 14)    About this table

Publications
for TCF4 gene

PubMed articles for TCF4 gene, integrated from 9 sources (see all 212) (see top 10): (articles sorted by number of sources associating them with TCF4)

Utopia: connect your pdf to the dynamic world of online information

1. A novel, heritable, expanding CTG repeat in an intron of the SEF2-1 gene on chromosome 18q21.1. (PubMed id 9302263)^{1, 2, 3} Breschel T.S.... Ross C.A. (1997)
2. Sequence of the cDNA encoding ITF-2, a positive-acting transcription factor. (PubMed id 2308860)^{1, 2, 3} Henthorn P.... Kadesch T. (1990)
3. Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers. (PubMed id 1681116)^{1, 2, 9} Corneliussen B.... Grundstroem T. (1991)
4. Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and s plicing. (PubMed id 21789225)^{1, 2} Sepp M....Timmusk T. (2011)
5. Novel comprehensive diagnostic strategy in pitt-hopkins syndrome: Clinical score and further delineation of the TCF4 mutational spectrum. (PubMed id 22045651)^{1, 2} Whalen S.... Giurgea I. (2011)
6. Mutational, functional, and expression studies of the TCF4 gene in Pitt-Hopkins syndrome. (PubMed id 19235238)^{1, 2} de Pontual L.... Amiel J. (2009)
7. Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction. (PubMed id 17436254)^{1, 2} Amiel J.... Colleaux L. (2007)
8. Haploinsufficiency of TCF4 causes syndromal mental retardation with intermittent hyperventilation (Pitt-Hopkins syndrome). (PubMed id 17436255)^{1, 2} Zweier C.... Rauch A. (2007)
9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
11. Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif. (PubMed id 2105528)^{1, 2} Henthorn P.... Kadesch T. (1990)
12. CpG methylation in exon 1 of transcription factor 4 increases with age in normal gastric mucosa and is associated with gene silencing in intestinal-type gastric cancers. (PubMed id 18635522)^{1, 9} Kim S.K....Kim Y.S. (2008)
13. Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B. (PubMed id 18792017)^{1, 9} Nagasawa M....Blom B. (2008)
14. HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex. (PubMed id 10903890)^{1, 9} Persson P....Axelson H. (2000)
15. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. (PubMed id 18854153)^{1, 9} Cisse B....Reizis B. (2008)
16. Disruption of the TCF4 gene in a girl with mental retardation but without the classical Pitt-Hopkins syndrome. (PubMed id 18627065)^{1, 9} Kalscheuer V.M....Ropers H.H. (2008)
17. Short communication: RNA interference directed agains t Axin1 upregulates human immunodeficiency virus type 1 gene expression by acti vating the Wnt signaling pathway in HeLa-derived J111 cells. (PubMed id 19778269)^{1, 9} Kameoka M....Auwanit W. (2009)
18. A negative regulatory element-dependent inhibitory role of ITF2B on IL-2 receptor alpha gene. (PubMed id 16126178)^{1, 9} Lu Y....Shen Y.F. (2005)
19. Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. (PubMed id 11756408)^{1, 9} Jogi A....Axelson H. (2002)
20. Common variants conferring risk of schizophrenia. (PubMed id 19571808)^{1, 9} Stefansson H....Collier D.A. (2009)
21. Further delineation of Pitt-Hopkins syndrome: phenotypic and genotypic description of 16 novel patients. (PubMed id 18728071)^{2, 9} Zweier C....Rauch A. (2008)
22. Association of TCF4 and CLU polymorphisms with Fuchs' endothelial dystrophy and implication of CLU and TGFBI proteins in the disease p rocess. (PubMed id 22234156)¹ Kuot A....Burdon K.P. (2012)
23. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared wit h bipolar disorder. (PubMed id 22688191)¹ Bergen S.E....Sullivan P.F. (2012)
24. SPINDLIN1 promotes cancer cell proliferation through a ctivation of WNT/TCF-4 signaling. (PubMed id 22258766)¹ Wang J.X....Pei X.T. (2012)
25. b-catenin inhibits promyelocytic leukemia protein tumo r suppressor function in colorectal cancer cells. (PubMed id 22155184)¹ Satow R....Yamada T. (2012)
26. The TCF4/b-catenin pathway and chromatin structure coo perate to regulate D-glucuronyl C5-epimerase expression in breast cancer. (PubMed id 22805760)¹ Mostovich L.A....Grigorieva E.V. (2012)
27. Role of b-catenin and TCF/LEF family members in transc riptional activity of HIV in astrocytes. (PubMed id 22156527)¹ Narasipura S.D....Al-Harthi L. (2012)
28. Transcription factor 4 and myocyte enhancer factor 2C mutations are not common causes of Rett syndrome. (PubMed id 22383159)¹ Armani R....Christodoulou J. (2012)
29. KLF4 and SOX9 transcription factors antagonize b-caten in and inhibit TCF-activity in cancer cells. (PubMed id 22766303)¹ Sellak H....Lincoln T.M. (2012)
30. Role of the TCF4 gene intronic variant in normal varia tion of corneal endothelium. (PubMed id 22146553)¹ Mackey D.A....Pennell C.E. (2012)
31. Capsaicin represses transcriptional activity of b-cate nin in human colorectal cancer cells. (PubMed id 21764279)¹ Lee S.H....Baek S.J. (2012)
32. Schizophrenia risk polymorphisms in the TCF4 gene inte ract with smoking in the modulation of auditory sensory gating. (PubMed id 22451930)¹ Quednow B.B....Winterer G. (2012)
33. Kindlin 2 forms a transcriptional complex with b-caten in and TCF4 to enhance Wnt signalling. (PubMed id 22699938)¹ Yu Y....Zhang H. (2012)
34. Pitt-Hopkins syndrome-associated mutations in TCF4 lea d to variable impairment of the transcription factor function ranging from hypom orphic to dominant-negative effects. (PubMed id 22460224)¹ Sepp M....Timmusk T. (2012)
35. Sox4 functions as a positive regulator of b-catenin si gnaling through upregulation of TCF4 during morular differentiation of endometri al carcinomas. (PubMed id 22231735)¹ Saegusa M....Kuwata T. (2012)
36. Identification of novel T cell factor 4 (TCF-4) bindin g sites on the HIV long terminal repeat which associate with TCF-4, b-catenin, a nd SMAR1 to repress HIV transcription. (PubMed id 22674979)¹ Henderson L.J....Al-Harthi L. (2012)
37. Genome-wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. (PubMed id 22821403)¹ Ellinghaus D....Karlsen T.H. (2012)
38. Transcription factor TCF4 maintains the properties of human corneal epithelial stem cells. (PubMed id 22232078)¹ Lu R....Li D.Q. (2012)
39. The role of the TCF4 gene in the phenotype of individ uals with 18q segmental deletions. (PubMed id 21671075)¹ Hasi M....Cody J.D. (2011)
40. Association between TCF4 and schizophrenia does not e xert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain. (PubMed id 21812098)¹ Williams H.J....O'Donovan M.C. (2011)
41. Genome-wide association study identifies five new schi zophrenia loci. (PubMed id 21926974)¹ (2011)
42. I^-catenin/Tcf-4 complex transcriptionally regulates A KT1 in glioma. (PubMed id 21720709)¹ Chen L....Kang C. (2011)
43. Common variants at VRK2 and TCF4 conferring risk of s chizophrenia. (PubMed id 21791550)¹ Steinberg S....Stefansson K. (2011)
44. I^-catenin/TCF4 complex induces the epithelial-to-mese nchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness. (PubMed id 22080605)¹ SA!nchez-TillA^ E....Postigo A. (2011)
45. Human FasL gene is a target of I^-catenin/T-cell facto r pathway and complex FasL haplotypes alter promoter functions. (PubMed id 22022540)¹ Wu J....Kimberly R.P. (2011)
46. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
47. Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching. (PubMed id 21599871)¹ Eichhoff O.M....Hoek K.S. (2011)
48. Association of TCF4 gene polymorphisms with Fuchs' co rneal dystrophy in the Chinese. (PubMed id 21659310)¹ Thalamuthu A....Vithana E.N. (2011)
49. The schizophrenia risk allele C of the TCF4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and health y volunteers. (PubMed id 21543597)¹ Quednow B.B....Kumari V. (2011)
50. Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnosti c boundaries. (PubMed id 21037240)¹ Williams H.J....O'Donovan M.C. (2011)
51. Novel schizophrenia risk gene TCF4 influences verbal learning and memory functioning in schizophrenia patients. (PubMed id 21228604)¹ Lennertz L....MAPssner R. (2011)
52. Genome-wide meta-analysis for severe diabetic retinop athy. (PubMed id 21441570)¹ Grassi M.A....Nicolae D.L. (2011)
53. Histone H4 Lys 20 monomethylation by histone methylas e SET8 mediates Wnt target gene activation. (PubMed id 21282610)¹ Li Z....Li L. (2011)
54. Tumor-suppressive effects of psoriasin (S100A7) are me diated through the b-catenin/T cell factor 4 protein pathway in estrogen recepto r-positive breast cancer cells. (PubMed id 22016394)¹ Deol Y.S....Ganju R.K. (2011)
55. Replication of the TCF4 intronic variant in late-onse t Fuchs corneal dystrophy and evidence of independence from the FCD2 locus. (PubMed id 21245398)¹ Riazuddin S.A....Gottsch J.D. (2011)
56. Replication of TCF4 through association and linkage s tudies in late-onset Fuchs endothelial corneal dystrophy. (PubMed id 21533127)¹ Li Y.J....Afshari N.A. (2011)
57. Silencing of the Wnt transcription factor TCF4 sensit izes colorectal cancer cells to (chemo-) radiotherapy. (PubMed id 21983179)¹ Kendziorra E....Grade M. (2011)
58. Interference of E2-2-mediated effect in endothelial c ells by FAM96B through its limited expression of E2-2. (PubMed id 21722264)¹ Yang W....Kato M. (2011)
59. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
60. TIF1gamma controls erythroid cell fate by regulating transcription elongation. (PubMed id 20603019)¹ Bai X....Zon L.I. (2010)
61. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010)
62. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
63. TCF4, schizophrenia, and Pitt-Hopkins Syndrome. (PubMed id 20421335)¹ Blake D.J....Owen M.J. (2010)
64. CpG methylation of transcription factor 4 in gastric carcinoma. (PubMed id 20585880)¹ Joo J.K....Lee J.H. (2010)
65. Pitt-Hopkins syndrome: report of a case with a TCF4 g ene mutation. (PubMed id 20205897)¹ Taddeucci G....Tarantino E. (2010)
66. Global regulator SATB1 recruits beta-catenin and regu lates T(H)2 differentiation in Wnt-dependent manner. (PubMed id 20126258)¹ Notani D....Galande S. (2010)
67. Common variants in major histocompatibility complex r egion and TCF4 gene are significantly associated with schizophrenia in Han Chin ese. (PubMed id 20673877)¹ Li T....Shi Y. (2010)
68. E2-2 protein and Fuchs's corneal dystrophy. (PubMed id 20825314)¹ Baratz K.H....Edwards A.O. (2010)
69. ITF2 is a target of CXCR4 in MDA-MB-231 breast cancer cells and is associated with reduced survival in estrogen receptor-negative br east cancer. (PubMed id 20603605)¹ Appaiah H....Nakshatri H. (2010)
70. The ubiquitin specific protease 4 (USP4) is a new pla yer in the Wnt signalling pathway. (PubMed id 20141612)¹ Zhao B....Lindsten K. (2009)
71. Common polygenic variation contributes to risk of sch izophrenia and bipolar disorder. (PubMed id 19571811)¹ (2009)
72. Daxx positively modulates beta-catenin/TCF4-mediated transcriptional potential. (PubMed id 19563778)¹ Huang Y.S. and Shih H.M. (2009)
73. The transcription factor ITF-2A induces cell cycle ar rest via p21(Cip1). (PubMed id 19635457)¹ Herbst A....Kolligs F.T. (2009)
74. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)¹ Yerges L.M....Zmuda J.M. (2009)
75. ITF-2 is disrupted via allelic loss of chromosome 18q 21, and ITF-2B expression is lost at the adenoma-carcinoma transition. (PubMed id 19394332)¹ Herbst A....Kolligs F.T. (2009)
76. Genotype-phenotype analysis of TCF4 mutations causing Pitt-Hopkins syndrome shows increased seizure activity with missense mutations . (PubMed id 19938247)¹ Rosenfeld J.A....Shaffer L.G. (2009)
77. Deletion 18q21.2q21.32 involving TCF4 in a boy diagnosed by CGH-array. (PubMed id 18222743)¹ Andrieux J....Holder-Espinasse M. (2008)
78. A conserved domain in the transcription factor ITF-2B attenuates its activity. (PubMed id 18371301)¹ Herbst A. and Kolligs F.T. (2008)
79. Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. (PubMed id 18281465)¹ Tran H.... Bienz M. (2008)
80. Menin promotes the Wnt signaling pathway in pancreatic endocrine cells. (PubMed id 19074834)¹ Chen G....Sawicki M.P. (2008)
81. Severe mental retardation with breathing abnormalities (Pitt-Hopkins syndrome) is caused by haploinsufficiency of the neuronal bHLH transcription factor TCF4. (PubMed id 17478476)¹ Brockschmidt A....Weber R.G. (2007)
82. SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation. (PubMed id 17412698)¹ Iguchi H....Sakai J. (2007)
83. HER-2/neu transcriptionally activates Jab1 expression via the AKT/beta-catenin pathway in breast cancer cells. (PubMed id 17914096)¹ Hsu M.C....Hung W.C. (2007)
84. CBP/p300 are bimodal regulators of Wnt signaling. (PubMed id 17410209)¹ Li J....Cadigan K.M. (2007)
85. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
86. Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo. (PubMed id 16630820)¹ Mosimann C....Basler K. (2006)
87. HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. (PubMed id 16724116)¹ Valenta T....Korinek V. (2006)
88. NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). (PubMed id 16714285)¹ Yamada M.... Shibuya H. (2006)
89. Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. (PubMed id 16950124)¹ Lei Q....Matise M.P. (2006)
90. ETO2 coordinates cellular proliferation and differentiation during erythropoiesis. (PubMed id 16407974)¹ Goardon N....Hoang T. (2006)
91. Protein interaction screening by quantitative immunop recipitation combined with knockdown (QUICK). (PubMed id 17072306)¹ Selbach M. and Mann M. (2006)
92. Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells. (PubMed id 17050667)¹ Shekhar M.P....Gerard B. (2006)
93. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)² Nusbaum C.... Lander E.S. (2005)
94. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. (PubMed id 16007074)¹ Nateri A.S....Behrens A. (2005)
95. Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis. (PubMed id 15684397)¹ Edlund S....Landstrom M. (2005)
96. SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy- dependent activation of Tcf-4. (PubMed id 15831457)¹ Ihara M.... Kikuchi A. (2005)
97. Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. (PubMed id 15331612)¹ Li Q. and Dashwood R.H. (2004)
98. E protein silencing by the leukemogenic AML1-ETO fusion protein. (PubMed id 15333839)¹ Zhang J....Roeder R.G. (2004)
99. Differential cooperation between dHAND and three different E-proteins. (PubMed id 15351717)¹ Murakami M....Kurihara H. (2004)
100. Hot spots in Tcf4 for the interaction with beta-catenin. (PubMed id 12657632)¹ Fasolini M....Knapp S. (2003)
101. Sumoylation is involved in beta-catenin-dependent activation of Tcf- 4. (PubMed id 12727872)¹ Yamamoto H.... Kikuchi A. (2003)
102. Functional localization and competition between the androgen receptor and T-cell factor for nuclear beta-catenin: a means for inhibition of the Tcf signaling axis. (PubMed id 12944908)¹ Mulholland D.J....Nelson C.C. (2003)
103. Phosphorylation and regulation of beta-catenin by casein kinase I epsilon. (PubMed id 12417018)¹ Sakanaka C. (2002)
104. Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains. (PubMed id 11802795)¹ Knofler M....Husslein P. (2002)
105. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
106. A novel target recognition revealed by calmodulin in complex with the basic helix--loop--helix transcription factor SEF2-1/E2-2. (PubMed id 11266605)¹ Larsson G....Wijmenga S.S. (2001)
107. Tcf4 can specifically recognize beta-catenin using alternative conformations. (PubMed id 11713475)¹ Graham T.A.... Xu W. (2001)
108. Protein-protein interaction panel using mouse full-length cDNAs. (PubMed id 11591653)¹ Suzuki H....Hayashizaki Y. (2001)
109. Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1. (PubMed id 11500377)¹ Sampson E.M....Yee A.S. (2001)
110. Structure of a human Tcf4-beta-catenin complex. (PubMed id 11713476)¹ Poy F.... Eck M.J. (2001)
111. Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice. (PubMed id 11784080)¹ Yoshida S....Nabeshima Y. (2001)
112. A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors. (PubMed id 10757985)¹ Onions J....Grundstrom T. (2000)
113. Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes. (PubMed id 9584154)¹ Massari M.E.... Murre C. (1998)
114. A splice variant of E2-2 basic helix-loop-helix protein represses the brain-specific fibroblast growth factor 1 promoter through the binding to an imperfect E-box. (PubMed id 9668116)¹ Liu Y....Chiu I.M. (1998)
115. SCL binds the human homologue of DRG in vivo. (PubMed id 9824680)¹ Zhao X.-F. and Aplan P.D. (1998)
116. The role of E-proteins in B- and T-lymphocyte development. (PubMed id 9618760)¹ Bain G. and Murre C. (1998)
117. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. (PubMed id 9242638)¹ Langlands K....Prochownik E.V. (1997)
118. Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression. (PubMed id 8999959)¹ Chen B. and Lim R.W. (1997)
119. Determinants of helix-loop-helix dimerization affinity. Random mutational analysis of SCL/tal. (PubMed id 8576241)¹ Goldfarb A.N....Shoham M. (1996)
120. The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene. (PubMed id 8978694)¹ Pscherer A....Schule R. (1996)
121. Pitt-Hopkins Syndrome (PubMed id 22934316)¹ Ardinger H.H....Saunders C.J. (1993)
122. (PubMed id 17467953)² 
123. Axin downregulates TCF-4 transcription via beta-caten in, but not p53, and inhibits the proliferation and invasion of lung cancer cel ls. (PubMed id 20122174)⁹ Yang L.H....Wang E.H. (2010)
124. Expression of T cell factor-4 in non-small-cell lung cancer. (PubMed id 15667799)⁹ Li C.Y....Wang E.H. (2005)
125. Inhibition of endothelial cell activation by bHLH pro tein E2-2 and its impairment of angiogenesis. (PubMed id 20231428)⁹ Tanaka A....Kato M. (2010)
126. Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling. (PubMed id 17283121)⁹ Idogawa M....Yamada T. (2007)
127. Transcription factor Egr1 acts as an upstream regulator of beta-catenin signalling through up-regulation of TCF4 and p300 expression during trans-differentiation of endometrial carcinoma cells. (PubMed id 18798221)⁹ Saegusa M....Okayasu I. (2008)
128. Upregulation of TCF4 expression as a transcriptional target of beta-catenin/p300 complexes during trans-differentiation of endometrial carcinoma cells. (PubMed id 15806138)⁹ Saegusa M....Okayasu I. (2005)
129. Alterations of beta-catenin and Tcf-4 instead of GSK-3beta contribute to activation of Wnt pathway in hepatocellular carcinoma. (PubMed id 14687479)⁹ Cui J....Romeih M. (2003)
130. Regulation of Wnt signaling by the nuclear pore complex. (PubMed id 18439914)⁹ Shitashige M....Yamada T. (2008)
131. Nuclear translocations of beta-catenin and TCF4 in gastric cancers correlate with lymph node metastasis but probably not with CD44 expression. (PubMed id 16311123)⁹ Chen X.Y....Liu J. (2005)
132. Aberrant expression and function of TCF4 in the proliferation of hepatocellular carcinoma cell line BEL-7402. (PubMed id 15040893)⁹ Zhao D.H....Li C.J. (2004)
133. Id2 is a primary partner for the E2-2 basic helix-loop-helix transcription factor in the human placenta. (PubMed id 15249128)⁹ Liu Y.P....Golos T.G. (2004)
134. The transcriptional factor Tcf-4 contains different binding sites for beta-catenin and plakoglobin. (PubMed id 11711551)⁹ Miravet S....Dunach M. (2002)
135. HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation. (PubMed id 15928669)⁹ Jung C....Kao C. (2005)
136. Wnt signaling in hepatocellular carcinoma: analysis of mutation and expression of beta-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes. (PubMed id 12603528)⁹ Cui J....Romeih M. (2003)
137. beta-Catenin and plakoglobin N- and C-tails determine ligand specificity. (PubMed id 15381698)⁹ Solanas G....Dunach M. (2004)
138. The human T-cell factor-4 gene splicing isoforms, Wnt signal pathway, and apoptosis in renal cell carcinoma. (PubMed id 12796377)⁹ Shiina H....Dahiya R. (2003)
139. Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability. (PubMed id 10597289)⁹ Duval A....Hamelin R. (1999)
140. HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors. (PubMed id 1312219)⁹ Hu J.S.... Kingston R.E. (1992)
141. The class I bHLH factors E2-2A and E2-2B regulate EMT. (PubMed id 19295128)⁹ Sobrado V.R....Cano A. (2009)
142. Characterization of sequences in human TWIST required for nuclear localization. (PubMed id 19534813)⁹ Singh S. and Gramolini A.O. (2009)
143. Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex. (PubMed id 15940627)⁹ Idogawa M....Hirohashi S. (2005)
144. Evolution of vertebrate E protein transcription factors: comparative analysis of the E protein gene family in Takifugu rubripes and humans. (PubMed id 15713784)⁹ Hikima J....Warr G.W. (2005)
145. Ligand activation of peroxisome proliferator-activated receptor gamma induces apoptosis of leukemia cells by down-regulating the c-myc gene expression via blockade of the Tcf-4 activity. (PubMed id 11973610)⁹ Yamakawa-Karakida N....Nakazawa S. (2002)
146. TAL1/SCL relieves the E2-2-mediated repression of VEGFR2 promoter activity. (PubMed id 19029143)⁹ Tanaka A....Kato M. (2009)
147. Agelastatin A: a novel inhibitor of osteopontin-mediated adhesion, invasion, and colony formation. (PubMed id 18347142)⁹ Mason C.K....El-Tanani M. (2008)
148. E-box protein E2-2 is a crucial regulator of plasmacytoid DC development. (PubMed id 18792016)⁹ Esashi E. and Liu Y.J. (2008)
149. BMPs restrict the position of premuscle masses in the limb buds by influencing Tcf4 expression. (PubMed id 17005177)⁹ Bonafede A....Brand-Saberi B. (2006)
150. Regulation of human neurotropic JCV in colon cancer c ells. (PubMed id 16619477)⁹ Enam S....Khalili K. (2006)
151. Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. (PubMed id 15670774)⁹ Park C.H....Yang C.H. (2005)
152. APC 3 x 15 beta-catenin-binding domain potentiates beta-catenin association to TBP and upregulates TCF-4 transcriptional activity. (PubMed id 13679048)⁹ Roura S....Dunach M. (2003)
153. Nitric oxide-donating aspirin inhibits beta-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear beta-catenin-TCF association. (PubMed id 14566053)⁹ Nath N....Rigas B. (2003)
154. Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways. (PubMed id 12566320)⁹ Araki Y....Harris C.C. (2003)
155. Reconstructed beta-catenin/TCF4 signaling in yeast applicable to functional evaluation of APC mutations. (PubMed id 14633595)⁹ Yamada H....Katoh H. (2003)
156. Epstein-Barr virus latent membrane protein-1 effects on junctional plakoglobin and induction of a cadherin switch. (PubMed id 19584275)⁹ Shair K.H....Raab-Traub N. (2009)
157. Silencing mediator for retinoid and thyroid hormone receptor and nuclear receptor corepressor attenuate transcriptional activation by the beta-catenin-TCF4 complex. (PubMed id 18632669)⁹ Song L.N. and Gelmann E.P. (2008)
158. Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction. (PubMed id 15060161)⁹ Levy L....Neuveut C. (2004)
159. Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line. (PubMed id 14661054)⁹ Maeda O....Sekido Y. (2004)
160. Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. (PubMed id 12556519)⁹ Hino S.... Kikuchi A. (2003)
161. Transcriptional regulation of osteopontin and the metastatic phenotype: evidence for a Ras-activated enhancer in the human OPN promoter. (PubMed id 12650610)⁹ Denhardt D.T....Rittling S.R. (2003)
162. Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells. (PubMed id 12235165)⁹ Holnthoner W....Petzelbauer P. (2002)
163. Role of beta-catenin/T-cell factor-regulated genes in ovarian endometrioid adenocarcinomas. (PubMed id 11943708)⁹ Zhai Y....Cho K.R. (2002)
164. Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer. (PubMed id 11396184)⁹ Dimberg J....Soderkvist P. (2001)
165. Heregulin induces expression, DNA binding activity, and transactivating functions of basic leucine zipper activating transcription factor 4. (PubMed id 10667576)⁹ Talukder A.H....Kumar R. (2000)
166. Overlapping expression of early B-cell factor and basic helix-loop-helix proteins as a mechanism to dictate B-lineage-specific activity of the lambda5 promoter. (PubMed id 10779354)⁹ Sigvardsson M. (2000)
167. Somatic frameshift alterations in mononucleotide repeat-containing genes in different tumor types from an HNPCC family with germline MSH2 mutation. (PubMed id 10918391)⁹ Planck M....Nilbert M. (2000)
168. Functional replacement of the mouse E2A gene with a human HEB cDNA. (PubMed id 9584174)⁹ Zhuang Y....Dai M. (1998)
169. Identification of c-MYC as a target of the APC pathway. (PubMed id 9727977)⁹ He T.-C.... Kinzler K.W. (1998)
170. [The possibility of regenerative medicine for myocard ial infarction and ischemic cardiomyopathy by using several stem cells] (PubMed id 20387569)⁹ Egashira T. and Fukuda K. (2010)
171. A STAT4 risk allele is associated with ischaemic cere brovascular events and anti-phospholipid antibodies in systemic lupus erythemat osus. (PubMed id 19762360)⁹ Svenungsson E....RAPnnblom L. (2010)
172. Generation of iPSCs from cultured human malignant cel ls. (PubMed id 20233975)⁹ Carette J.E....Brummelkamp T.R. (2010)
173. Effects of potential calcium sensing receptor inducer s on promoting chemosensitivity of human colon carcinoma cells. (PubMed id 20428782)⁹ Wang X....Liu G. (2010)
174. Silibinin suppresses growth of human colorectal carci noma SW480 cells in culture and xenograft through down-regulation of beta-caten in-dependent signaling. (PubMed id 20454513)⁹ Kaur M....Agarwal R. (2010)
175. Activator protein 2alpha suppresses intestinal tumori genesis in the Apc(min) mouse. (PubMed id 19376641)⁹ Li Q....Dashwood R.H. (2009)
176. Repression of tau hyperphosphorylation by chronic end urance exercise in aged transgenic mouse model of tauopathies. (PubMed id 19360903)⁹ Leem Y.H....Han P.L. (2009)
177. Cardiac regenerative medicine. (PubMed id 18772528)⁹ Yuasa S. and Fukuda K. (2008)
178. Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity. (PubMed id 19114997)⁹ Raurell I....DuA+ach M. (2008)
179. Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival. (PubMed id 18465804)⁹ Chen K....Uren A. (2008)
180. The physiological and pharmacological basis for the ergogenic effects of androgens in elite sports. (PubMed id 18385897)⁹ Choong K....Bhasin S. (2008)
181. Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. (PubMed id 17220880)⁹ Kaidi A....Paraskeva C. (2007)
182. Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing. (PubMed id 17383426)⁹ Shitashige M....Yamada T. (2007)
183. A functional role of Cdx2 in beta-catenin signaling during transdifferentiation in endometrial carcinomas. (PubMed id 17468517)⁹ Saegusa M....Okayasu I. (2007)
184. Physical and functional cooperation between AP-1 and beta-catenin for the regulation of TCF-dependent genes. (PubMed id 17146436)⁹ Toualbi K....Bernuau D. (2007)
185. Wnt expression and canonical Wnt signaling in human bone marrow B lymphopoiesis. (PubMed id 16808837)⁹ Dosen G.... Rian E. (2006)
186. Effects of gastrin 17 on beta-catenin/Tcf-4 pathway in Colo320WT colon cancer cells. (PubMed id 17167838)⁹ Cao J....Yu H.G. (2006)
187. Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. (PubMed id 16568448)⁹ Trosset J.Y....Moll J.K. (2006)
188. Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells. (PubMed id 16645588)⁹ Roesch A....Vogt T. (2006)
189. Presenilin-1 interacts with plakoglobin and enhances plakoglobin-Tcf-4 association. Implications for the regulation of beta-catenin/Tcf-4-dependent transcription. (PubMed id 16306047)⁹ Raurell I....Dunach M. (2006)
190. Proteomic analysis of individual human embryos to ide ntify novel biomarkers of development and viability. (PubMed id 16412738)⁹ Katz-Jaffe M.G....Schoolcraft W.B. (2006)
191. Overexpression of human pituitary tumor transforming gene (hPTTG), is regulated by beta-catenin /TCF pathway in human esophageal squamous cell carcinoma. (PubMed id 15514942)⁹ Zhou C....Xu N. (2005)
192. Wnt breakers in colon cancer. (PubMed id 14749120)⁹ Clevers H. (2004)
193. Expression profiling and functional analysis of wnt signaling mechanisms in mesenchymal stem cells. (PubMed id 15342948)⁹ Etheridge S.L....Genever P.G. (2004)
194. Targeted degradation of beta-catenin by chimeric F-box fusion proteins. (PubMed id 14706645)⁹ Liu J....White R.L. (2004)
195. Survival and proliferation factors of normal and malignant plasma cells. (PubMed id 12953803)⁹ Klein B....Rossi J.F. (2003)

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