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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCF3 Gene

protein-coding   GIFtS: 65
GCID: GC19M001609

Transcription Factor 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcription Factor 31 2 3     bHLHb212 3
Immunoglobulin Transcription Factor 11 2 3     E2A Immunoglobulin Enhancer-Binding Factor E12/E471
Kappa-E2-Binding Factor1 2 3     E472
E2A2 3 5     VDIR2
Transcription Factor E2-Alpha1 2     Helix-Loop-Helix Protein HE472
VDR Interacting Repressor1 2     Negative Vitamin D Response Element-Binding Protein2
Class B Basic Helix-Loop-Helix Protein 212 3     Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors
E12/E47)2
Transcription Factor ITF-12 3     Vitamin D Receptor-Interacting Repressor2
ITF12 3     BHLHB213
TCF-32 3     Immunoglobulin Enhancer-Binding Factor E12/E473

External Ids:    HGNC: 116331   Entrez Gene: 69292   Ensembl: ENSG000000715647   OMIM: 1471415   UniProtKB: P159233   

Export aliases for TCF3 gene to outside databases

Previous GC identifers: GC19M001671 GC19M001549 GC19M001560 GC19M001384


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCF3 Gene:
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins
activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers,
and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E
proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte
development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid
malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid
malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia
(t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the
short arm of chromosome 9. (provided by RefSeq, Sep 2011)

GeneCards Summary for TCF3 Gene: 
TCF3 (transcription factor 3) is a protein-coding gene. Diseases associated with TCF3 include acute lymphoblastic leukemia, and childhood leukemia, and among its related super-pathways are MAPK Signaling and Myogenesis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TCF12.

UniProtKB/Swiss-Prot: TFE2_HUMAN, P15923
Function: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between
TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific
cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs:
5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which
are short DNA sequences in the insulin gene transcription control region

Gene Wiki entry for TCF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCF3 gene promoter:
         AML1a   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TCF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TCF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCF3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M001609:  view genomic region     (about GC identifiers)

Start:
1,609,291 bp from pter      End:
1,652,604 bp from pter
Size:
43,314 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TFE2_HUMAN, P15923 (See protein sequence)
Recommended Name: Transcription factor E2-alpha  
Size: 654 amino acids; 67600 Da
Subunit: Forms a heterodimer with ASH1 and TWIST2. Isoform E12 interacts with RALGAPA1 and FIGLA. Efficient DNA
binding requires dimerization with another bHLH protein. Component of a nuclear TAL-1 complex composed at least
of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with NEUROD2, PTF1A and TGFB1I1 (By similarity). Homodimer.
Heterodimer. Forms a heterodimer with NEUROD1; the heterodimer is inhibited in presence of ID2, but not NR0B2, to
E-box element. Interacts with EP300 and UBE2I
Subcellular location: Nucleus
Sequence caution: Sequence=AAA52331.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for TCF3:
1HLH (3D)        3U5V (3D)    
Secondary accessions: P15883 Q14208 Q14635 Q14636 Q2TB40 Q9UPI9
Alternative splicing: 2 isoforms:  P15923-1   P15923-2   (The bHLH domain encompassing amino-acids 546 to 599 is sufficient to mediate DNA-binding and homodimerization. Combined mutagenesis of Phe-566 and Leu-569 to Asp-566 and Glu-569, mutagenesis of Lys-585 to Ala-585 or combined mutagenesis of Ile-588 and Leu-589 to Asp-588 and Glu-589 prevents DNA-binding and homodimerization. Mutagenesis of Arg-548 to Lys-548, combined mutagenesis of Arg-547 and Arg-548 to Gly-547 and Gly-548, mutagenesis of Arg-556 to Lys-556, mutagenesis of Arg-558 to Lys-558, or combined mutagenesis of Arg-556 and Arg-558 to Gly-556 and Gly-558, alter DNA-binding but not dimerization. Contains a phosphothreonine at position 531)

Explore the universe of human proteins at neXtProt for TCF3: NX_P15923

Explore proteomics data for TCF3 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated following NGF stimulation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P15923

  • TCF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCF3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129611.1  NP_003191.1  

    ENSEMBL proteins: 
     ENSP00000465251   ENSP00000262965   ENSP00000467508   ENSP00000396363   ENSP00000465549  
     ENSP00000468481   ENSP00000465510   ENSP00000378813   ENSP00000468487   ENSP00000466565  
     ENSP00000467972   ENSP00000465481   ENSP00000466952   ENSP00000467388   ENSP00000466052  
     ENSP00000466954   ENSP00000344375  
    Reactome Protein details: P15923
    Human Recombinant Protein Products for TCF3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Proteins for TCF3
    OriGene Protein Over-expression Lysate for TCF3
    OriGene MassSpec for TCF3 
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    Novus Biologicals TCF3 Proteins
    Novus Biologicals TCF3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000788nuclear nucleosome IEA--
    GO:0005634nucleus NAS2493990
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IDA10775504
    GO:0005737cytoplasm IDA12435739

    TCF3 for ontologies           About GeneDecksing



    TCF3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TCF3
    R&D Systems Antibodies for TCF3 (TCF-3/E2A)
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    Abcam antibodies for TCF3
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    ThermoFisher Antibodies for TCF3
    LSBio Antibodies in human, mouse, rat for TCF3 

    Assay Products for TCF3: 
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    GenScript Custom Assay Services for TCF3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry P15923

    ProtoNet protein and cluster: P15923

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: TFE2_HUMAN, P15923
    Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription
    factors
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    TCF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFE2_HUMAN, P15923
    Function: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between
    TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific
    cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs:
    5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which
    are short DNA sequences in the insulin gene transcription control region

         Genatlas biochemistry entry for TCF3:
    transcription factor 3,heterodimerizing with all myogenic bHLH vproteins and binding DNA cooperatively with
    PBXs/MEISs/PKNOX1

         Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS2105528
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS2493990
    GO:0003713transcription coactivator activity IDA14752053
    GO:0005515protein binding IPI10903890
         
    TCF3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TCF3:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         15 MGI mutant phenotypes (inferred from 21 alleles(MGI details for Tcf3):
     cellular  embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  nervous system 
     no phenotypic analysis  normal  renal/urinary system  reproductive system  tumorigenesis 

    TCF3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TCF3: Tcf3tm1Zhu Tcf3tm4.1Cmu Tcf3tm3.1Cmu Tcf3tm1Wein Tcf3tm1.2Mbu Tcf3tm1Cmu
                                                         Tcf3tm2Cmu

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TCF3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TCF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCF3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TCF3 

    10/2267 SABiosciences Target genes for TCF3 (see all 2267):
    AADAT AANAT ABAT ABCA7 ABCB4 ABCB7 ABCB8 ABCC10 ABCC5 ABCD2

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCF3
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate TCF3 (see all 39):
    hsa-miR-323-3p hsa-miR-300 hsa-miR-15a hsa-miR-1304 hsa-miR-374c hsa-miR-424 hsa-miR-124 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidTCF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
    Products:
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for TCF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TCF3 (NM_003200)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF3
    Sirion Biotech Customized lentivirus for stable overexpression of TCF3 
                         Customized lentivirus expression plasmids for stable overexpression of TCF3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TCF3 About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Rho Family GTPases
    MAPK Signaling0.58
    ILK Signaling0.49
    Molecular Mechanisms of Cancer0.51
    2CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    3Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency0.50
    Factors Promoting Cardiogenesis in Vertebrates0.50
    4Axon guidance
    Developmental Biology0.69
    5TGF-Beta Pathway
    JNK Pathway0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TCF3
        Selected targets of CREB1

    5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCF3 (see all 10)
        MAPK Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for TCF3
        Lymphocyte Signaling

    5/7 BioSystems Pathways for TCF3 (see all 7)
        SIDS Susceptibility Pathways
    Wnt Signaling Pathway NetPath
    Id Signaling Pathway
    Delta-Notch Signaling Pathway
    p38 signaling mediated by MAPKAP kinases

    3        Reactome Pathways for TCF3
        Developmental Biology
    Myogenesis
    CDO in myogenesis


    2         Kegg Pathways  (Kegg details for TCF3):
        HTLV-I infection
    Transcriptional misregulation in cancer


    TCF3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/197 Interacting proteins for TCF3 (P159231, 2, 3 ENSP000002629654) via UniProtKB, MINT, STRING, and/or I2D (see all 197)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAL1P175421, 2, 3, ENSP000002943394EBI-769630,EBI-1753878 MINT-8142126 I2D: score=5 STRING: ENSP00000294339
    MYOD1P151721, 3, ENSP000002500034EBI-769645,EBI-488878 I2D: score=5 STRING: ENSP00000250003
    ASCL1P505531, 3, ENSP000002667444EBI-769630,EBI-957042 I2D: score=2 STRING: ENSP00000266744
    TCF12Q990812, 3, ENSP000003310574MINT-8142126 I2D: score=2 STRING: ENSP00000331057
    DAXXQ9UER73, ENSP000002660004I2D: score=1 STRING: ENSP00000266000
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000080G1 phase of mitotic cell cycle ----
    GO:0001779natural killer cell differentiation IEA--
    GO:0002326B cell lineage commitment NAS12435739
    GO:0006351transcription, DNA-dependent IDA10775504
    GO:0006355regulation of transcription, DNA-dependent NAS2493990

    TCF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCF3 (TFE2)

    Search CenterWatch for drugs/clinical trials and news about TCF3 / TFE2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCF3 gene (2 alternative transcripts): 
    NM_001136139.2  NM_003200.3  

    Unigene Cluster for TCF3:

    Transcription factor 3
    Hs.371282  [show with all ESTs]
    Unigene Representative Sequence: NM_003200
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592395 ENST00000262965(uc002lto.3 uc002ltq.3 uc002ltr.3)
    ENST00000587425 ENST00000453954(uc002ltt.4 uc002lts.1) ENST00000592628
    ENST00000593064 ENST00000585731 ENST00000395423(uc010dso.1) ENST00000588136
    ENST00000590684 ENST00000586164 ENST00000585855 ENST00000590605 ENST00000590436
    ENST00000586410 ENST00000587235 ENST00000586318 ENST00000344749(uc002ltn.3)

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    Additional mRNA sequence: 

    AK024806.1 AL117663.1 AY311345.1 BC005166.2 BC009346.1 BC011665.2 BC014680.1 BC110580.1 
    EU155120.1 M24404.1 M24405.1 M31222.1 M31523.1 M65214.1 X52078.1 

    24/39 DOTS entries (see all 39):

    DT.454302  DT.92019877  DT.119679  DT.91793901  DT.40133480  DT.95150823  DT.100867319  DT.91982919 
    DT.100647180  DT.97862408  DT.121441891  DT.91971358  DT.100647174  DT.91991861  DT.101960616  DT.121441845 
    DT.97811535  DT.121441872  DT.87078345  DT.91770899  DT.92030806  DT.92335324  DT.100893983  DT.102839502 

    24/423 AceView cDNA sequences (see all 423):

    AA608615 AI694331 BC005166 AI202041 BC014680 BE243532 BQ929289 AI292327 
    BE675719 AI278535 CD672414 AL117663 AA309772 CF887518 BU633486 AW575617 
    AI379099 BM855445 M65214 AW291864 BM552285 AI418460 AA459634 AI302267 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for TCF3 (see all 21)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c · 18d ·
    SP1:                                                  -                                                                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                -     -     -     -                                                                                                         
    SP5:                                                                                                                                                            

    ExUns: 18e · 18f ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21a · 21b · 21c · 21d · 21e · 21f · 21g ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c
    SP1:                          -     -     -     -                                                                                       
    SP2:              -     -     -                                               -     -     -     -     -     -                           
    SP3:                          -     -     -     -                                                                                       
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for TCF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCF3 expression in normal human tissues (normalized intensities)      TCF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAGATGCAA
    TCF3 Expression
    About this image


    TCF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Oligodendrocyte Precursor Cells Motor Neural Progenitor Domain
             Cerebral Cortex
             Olfactory Bulb   
     
     Blood (Hematopoietic System)    fully expand to see all 8 entries
             Common Lymphoid Progenitor Cells Hematopoietic Bone Marrow
             b cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 4 entries
             lymph node ; non-germinal center cells   
             LYMPH NODE   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Intermediate Keratinocytes Embryonic Epidermis

    See TCF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCF3

    SOURCE GeneReport for Unigene cluster: Hs.371282
        SABiosciences Expression via Pathway-Focused PCR Arrays including TCF3: 
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TCF3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcf31 , 5 transcription factor 31, 5 82.28(n)1
    83.93(a)1
      10 (39.72 cM)5
    214231  NM_001164149.11  NP_001157621.11 
     804095145 
    chicken
    (Gallus gallus)
    Aves TCF31 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) less 73.22(n)
    74.84(a)
      395146  NM_204486.2  NP_989817.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    TCF36
    Uncharacterized protein
    78(a)
    55(a)
    possible ortholog
    1 ↔ 1
    AAWZ02036688(11524-14458)
    GL344974.1(955-13099)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC526082 hypothetical protein MGC52608 76.54(n)    X66959.1 
    zebrafish
    (Danio rerio)
    Actinopterygii e122 human E12 homolog 76.53(n)   30310  NM_131094.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta da3 oogenesis transcription factor 56(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea hlh-26
    Protein HLH-2, isoform a
    22(a)
    1 → many
    I(7190848-7193916)


    ENSEMBL Gene Tree for TCF3 (if available)
    TreeFam Gene Tree for TCF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCF3 gene
    TCF122  TCF42  
    3 SIMAP similar genes for TCF3 using alignment to 14 protein entries:     TFE2_HUMAN (see all proteins):
    E2A/PBX1 fusion    TCF12    TCF4

    TCF3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TCF3
    PGOHUM00000236370


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1506 SNPs in TCF3 are shown (see all 1506)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363964
    A colorectal cancer sample4--see VAR_0363962 A V mis40--------
    rs1385658171,2
    --1608906(+) GACTTC/TGAGCC 2 -- ds50010--------
    rs1491168431,2
    C--1608955(+) AGCCC-/GGGGGG 2 -- ds50010--------
    rs1828551231,2
    C--1608959(+) CCGGGG/TGGGGG 2 -- ds50010--------
    rs751731041,2
    F--1608979(+) GATGGG/AGAGCC 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1874524351,2
    --1608983(+) GGGAGC/GCCTCC 2 -- ds50010--------
    rs1918342501,2
    --1608998(+) TGGGGA/GCTGGG 2 -- ds50010--------
    rs1840515551,2
    --1609077(+) AGCCAA/GTCCTG 2 -- ds50010--------
    rs1870782481,2
    --1609128(+) CCAGCC/TGCCCT 2 -- ds50010--------
    rs1922910831,2
    --1609214(+) GCACCC/TGAGGT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for TCF3 (1609291 - 1652604 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for TCF3 (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717846CNV Deletion23290073
    esv2717847CNV Deletion23290073
    esv2717848CNV Deletion23290073
    esv2717849CNV Deletion23290073
    esv2667087CNV Deletion23128226
    nsv138347CNV Loss16902084
    nsv910292CNV Loss21882294
    nsv910543CNV Loss21882294
    nsv910540CNV Loss21882294
    nsv910499CNV Loss21882294


    Human Gene Mutation Database (HGMD): TCF3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TCF3
    DNA2.0 Custom Variant and Variant Library Synthesis for TCF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147141    OMIM disorders: --

    UniProtKB/Swiss-Prot: TFE2_HUMAN, P15923
  • Note=Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia
    (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1. TCF3-PBX1 transforms cells by constitutively activating
    transcription of genes regulated by PBX1 or by other members of the PBX protein family. Translocation
    t(17;19)(q22;p13.3) with HLF. Inversion inv(19)(p13;q13) with TFPT

  • 20/37 diseases for TCF3 (see all 37):    About MalaCards
    acute lymphoblastic leukemia    childhood leukemia    lymphoblastic leukemia    acute leukemia
    alveolar soft part sarcoma    rheumatoid arthritis, association with    alk-positive anaplastic large cell lymphoma    hemophilia
    malt lymphoma    neuritis    hypercalcemia    gastrointestinal stromal tumor
    leukemia    follicular lymphoma    anaplastic large cell lymphoma    conjunctivitis
    rhabdomyosarcoma    thyroid cancer    retinoblastoma    chronic lymphocytic leukemia

    1 disease from the University of Copenhagen DISEASES database for TCF3:
    Leukemia

    TCF3 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TCF3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoblastic leukemia acute 30.4 2 10490826 (1), 17311319 (1)
    tumors 6.54 3 12161427 (1), 17982455 (1), 17311319 (1)
    leukemia 0 2 15030166 (1), 10471746 (1)

    Genatlas disease: TCF3
    acute lymphoblastic leukemia,pre-B cell,with translocation t(1;19)(q23;p13);see PBX1


    Export disorders for TCF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCF3 gene, integrated from 9 sources (see all 232):
    (articles sorted by number of sources associating them with TCF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor. (PubMed id 2308859)1, 2, 3 Henthorn P.... Kadesch T. (1990)
    2. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. (PubMed id 1967983)1, 2, 3 Kamps M.P.... Baltimore D. (1990)
    3. Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. (PubMed id 14752053)1, 2 Kim J.Y....Choi H.S. (2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    5. Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary. (PubMed id 15044608)1, 2 Bayne R.A.L.... Anderson R.A. (2004)
    6. Identification of a novel molecular partner of the E2A gene in childhood leukemia. (PubMed id 10086727)1, 2 Brambillasca F.... Privitera E. (1999)
    7. The mUBC9 murine ubiquitin conjugating enzyme interacts with the E2A transcription factors. (PubMed id 9409784)1, 2 Loveys D.A.... Kato G.J. (1997)
    8. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. (PubMed id 1386162)1, 2 Inaba T.... Look A.T. (1992)
    9. Sequence of a HeLa cDNA provides the DNA binding domain and carboxy terminus of HE47: a human helix-loop-helix protein related to the enhancer binding factor E47. (PubMed id 1818757)1, 2 Zhang Y. and Bina M. (1991)
    10. The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias. (PubMed id 1671560)1, 2 Hunger S.P....Cleary M.L. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6929 HGNC: 11633 AceView: TCF3 Ensembl:ENSG00000071564 euGenes: HUgn6929
    ECgene: TCF3 Kegg: 6929 H-InvDB: TCF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TCF3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCF3 gene:
    Search GeneIP for patents involving TCF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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