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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCF3 Gene

protein-coding   GIFtS: 64
GCID: GC19M001609

transcription factor 3
 Explore 45 diseases affiliated with
TCF3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TCF3    

Aliases
for TCF3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transcription Factor 31 2 3     MGC1296471
E2A1 2 3 5     MGC1296481
ITF11 2 3     Helix-Loop-Helix Protein HE472
BHLHb211     Negative Vitamin D Response Element-Binding Protein2
E471 2     Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47)2
VDIR1 2     Transcription Factor E2-Alpha2
Class B Basic Helix-Loop-Helix Protein 212 3     VDR Interacting Repressor2
Immunoglobulin Transcription Factor 12 3     Vitamin D Receptor-Interacting Repressor2
Kappa-E2-Binding Factor2 3     BHLHB213
Transcription Factor ITF-12 3     Immunoglobulin Enhancer-Binding Factor E12/E473
TCF-32 3     

External Ids:    HGNC: 116331   Entrez Gene: 69292   Ensembl: ENSG000000715647   OMIM: 1471415   UniProtKB: P159233   

Export aliases for TCF3 gene to outside databases

Previous GC identifers: GC19M001671 GC19M001549 GC19M001560 GC19M001384


Summaries
for TCF3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TCF3:
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins
activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are
inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a
critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of
this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also
involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell
acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia
(t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for
this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: TFE2_HUMAN, P15923
Function: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3
and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate
during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'.
Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA
sequences in the insulin gene transcription control region

Gene Wiki entry for TCF3


Genomic Views
for TCF3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCF3 gene promoter:
         AML1a   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TCF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TCF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCF3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M001609:  view genomic region     (about GC identifiers)

Start:
 1,609,291 bp from pter      End:
 1,652,604 bp from pter
Size:
 43,314 bases      Orientation:
 minus strand

Proteins
for TCF3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TFE2_HUMAN, P15923 (See protein sequence)
Recommended Name: Transcription factor E2-alpha  
Size: 654 amino acids; 67600 Da
Subunit: Forms a heterodimer with ASH1 and TWIST2. Isoform E12 interacts with RALGAPA1 and FIGLA. Efficient DNA binding
requires dimerization with another bHLH protein. Component of a nuclear TAL-1 complex composed at least of CBFA2T3,
LDB1, TAL1 and TCF3. Interacts with NEUROD2, PTF1A and TGFB1I1 (By similarity). Homodimer. Heterodimer. Forms a
heterodimer with NEUROD1; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element. Interacts
with EP300 and UBE2I
Subcellular location: Nucleus
Sequence caution: Sequence=AAA52331.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for TCF3:
1HLH (3D)        3U5V (3D)    
Secondary accessions: P15883 Q14208 Q14635 Q14636 Q2TB40 Q9UPI9
Alternative splicing: 2 isoforms:  P15923-1   P15923-2   (Contains a phosphothreonine at position 531. The bHLH domain encompassing amino-acids 546 to 599 is sufficient to mediate DNA-binding and homodimerization. Combined mutagenesis of Phe-566 and Leu-569 to Asp-566 and Glu-569, mutagenesis of Lys-585 to Ala-585 or combined mutagenesis of Ile-588 and Leu-589 to Asp-588 and Glu-589 prevents DNA-binding and homodimerization. Mutagenesis of Arg-548 to Lys-548, combined mutagenesis of Arg-547 and Arg-548 to Gly-547 and Gly-548, mutagenesis of Arg-556 to Lys-556, mutagenesis of Arg-558 to Lys-558, or combined mutagenesis of Arg-556 and Arg-558 to Gly-556 and Gly-558, alter DNA-binding but not dimerization)

Explore the universe of human proteins at neXtProt for TCF3: NX_P15923

Post-translational modifications:

  • Phosphorylated following NGF stimulation (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P15923

    • TCF3 Protein expression data from MOPED and PaxDb:    About this image 
    TCF3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129611.1  NP_003191.1  

    ENSEMBL proteins: 
     ENSP00000465251   ENSP00000262965   ENSP00000467508   ENSP00000396363   ENSP00000465549  
     ENSP00000468481   ENSP00000465510   ENSP00000378813   ENSP00000468487   ENSP00000466565  
     ENSP00000467972   ENSP00000465481   ENSP00000466952   ENSP00000467388   ENSP00000466052  
     ENSP00000466954   ENSP00000344375  
    Reactome Protein details: P15923
    Human Recombinant Protein Products for TCF3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): TCF3
    OriGene Protein Over-expression Lysate (see all 2): TCF3
    OriGene Custom Protein Services for TCF3 
    GenScript Custom Purified and Recombinant Proteins Services for TCF3
    Novus Biologicals TCF3 Proteins
    Novus Biologicals TCF3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TCF3

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000788nuclear nucleosome IEA--
    GO:0005634nucleus NAS2493990
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IDA10775504
    GO:0005737cytoplasm IDA12435739

    TCF3 for ontologies           About GeneDecksing



    TCF3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TCF3
    R&D Systems Antibodies for TCF3 (TCF-3/E2A)
    Cell Signaling Technology (CST) Antibodies for TCF3  (E2A)
    OriGene Antibodies (see all 2): TCF3
    OriGene Custom Antibody Services for TCF3 
    GenScript Custom Superior Antibodies Services for TCF3
    Novus Biologicals TCF3 Antibodies
    Abcam antibodies for TCF3 
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    ThermoFisher Antibodies for TCF3

    Assay Products for TCF3: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for TCF3
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    Uscn ELISAs and CLIAs for TCF3

    Protein Domains /
    Families
    for TCF3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TCF3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry P15923

    ProtoNet protein and cluster: P15923

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: TFE2_HUMAN, P15923
    Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription
    factors
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for TCF3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TFE2_HUMAN, P15923
    Function: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3
    and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate
    during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'.
    Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA
    sequences in the insulin gene transcription control region

         Genatlas biochemistry entry for TCF3:
    transcription factor 3,heterodimerizing with all myogenic bHLH vproteins and binding DNA cooperatively with
    PBXs/MEISs/PKNOX1

         Gene Ontology (GO): 5/15 molecular function terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS2105528
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS2493990
    GO:0003713transcription coactivator activity IDA14752053
    GO:0005515protein binding IPI11802795
         
    TCF3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TCF3:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         15 MGI mutant phenotypes (inferred from 21 alleles) (MGI details for Tcf3):
     cellular  embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  nervous system 
     no phenotypic analysis  normal  renal/urinary system  reproductive system  tumorigenesis 

    TCF3 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for TCF3: Tcf3tm1Zhu Tcf3tm4.1Cmu Tcf3tm3.1Cmu Tcf3tm1Wein Tcf3tm1.2Mbu Tcf3tm1Cmu
                                                   Tcf3tm2Cmu
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TCF3 

    10/2304 SABiosciences Target genes for TCF3 (see all 2304):
    AADAT AANAT ABAT ABCA7 ABCB4 ABCB7 ABCB8 ABCC10 ABCC5 ABCD2

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): TCF3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCF3
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate TCF3 (see all 39):
    hsa-miR-323-3p hsa-miR-300 hsa-miR-15a hsa-miR-1304 hsa-miR-374c hsa-miR-424 hsa-miR-124 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TCF3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCF3 (see all 7)
    OriGene shRNA RFP: TCF3
    OriGene siRNA: TCF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCF3
    Sirion Biotech Custom design and validation of potent shRNA sequences against TCF3 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TCF3
    Sirion Biotech Customized adenovirus for overexpression of TCF3 
    Sirion Biotech Customized adenovirus for potent knockdown of TCF3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCF3 (see all 12)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TCF3 (NM_003200)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF3 

    Cell Line
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    Search LifeMap BioReagents cell lines for TCF3
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF3


    Pathways & Interactions
    for TCF3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Rho Family GTPases
    		Molecular Mechanisms of Cancer0.51
    		ILK Signaling0.45
    		MAPK Signaling0.51
    2Human Embryonic Stem Cell Pluripotency
    		Human Embryonic Stem Cell Pluripotency1.00
    		Factors Promoting Cardiogenesis in Vertebrates0.50
    3Activation of p38 alpha/beta MAPK
    		CDO in myogenesis0.55
    		Myogenesis0.55
    4Lymphocyte Signaling
    		Lymphocyte Signaling1.00
    5Selected targets of CREB1
    		Selected targets of CREB11.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TCF3
        Selected targets of CREB1

    5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCF3 (see all 10)
        MAPK Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for TCF3
        Lymphocyte Signaling

    5/7 BioSystems Pathways for TCF3 (see all 7) 
        SIDS Susceptibility Pathways
    Delta-Notch Signaling Pathway
    Id Signaling Pathway
    Wnt Signaling Pathway NetPath
    p38 signaling mediated by MAPKAP kinases

    3        Reactome Pathways for TCF3
        Developmental Biology
    Myogenesis
    CDO in myogenesis



    TCF3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/189 Interacting proteins for TCF3 (P159231, 2, 3 ENSP000002629654) via UniProtKB, MINT, STRING, and/or I2D (see all 189)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAL1P175421, 2, 3, ENSP000002943394EBI-769630,EBI-1753878 MINT-8142126 I2D: score=5 STRING: ENSP00000294339
    MYOD1P151721, 3, ENSP000002500034EBI-769645,EBI-488878 I2D: score=5 STRING: ENSP00000250003
    ASCL1P505531, 3, ENSP000002667444EBI-769630,EBI-957042 I2D: score=2 STRING: ENSP00000266744
    TCF12Q990812, 3, ENSP000003310574MINT-8142126 I2D: score=2 STRING: ENSP00000331057
    CALM1P621583, ENSP000003494674I2D: score=5 STRING: ENSP00000349467
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000080G1 phase of mitotic cell cycle IDA11509675
    GO:0001779natural killer cell differentiation IEA--
    GO:0002326B cell lineage commitment NAS12435739
    GO:0006351transcription, DNA-dependent IDA10775504
    GO:0006355regulation of transcription, DNA-dependent NAS2493990

    TCF3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TCF3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCF3
    Search CenterWatch for drugs/clinical trials and news about TCF3 / TFE2 

    Transcripts
    for TCF3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TCF3 gene (2 alternative transcripts): 
    NM_001136139.2  NM_003200.3  

    Unigene Cluster for TCF3:

    Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
    Hs.371282  [show with all ESTs]
    Unigene Representative Sequence: NM_003200
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592395 ENST00000262965(uc002lto.3 uc002ltq.3 uc002ltr.3)
    ENST00000587425 ENST00000453954(uc002ltt.4 uc002lts.1) ENST00000592628
    ENST00000593064 ENST00000585731 ENST00000395423(uc010dso.1) ENST00000588136
    ENST00000590684 ENST00000586164 ENST00000585855 ENST00000590605 ENST00000590436
    ENST00000586410 ENST00000587235 ENST00000586318 ENST00000344749(uc002ltn.3)


    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate TCF3 (see all 39):
    hsa-miR-323-3p hsa-miR-300 hsa-miR-15a hsa-miR-1304 hsa-miR-374c hsa-miR-424 hsa-miR-124 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TCF3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCF3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCF3

    Additional cDNA sequence: 

    AK024806.1 AL117663.1 AY311345.1 BC005166.2 BC009346.1 BC011665.2 BC014680.1 BC110580.1 
    EU155120.1 M24404.1 M24405.1 M31222.1 M31523.1 M65214.1 X52078.1 

    24/37 DOTS entries (see all 37):

    DT.454302  DT.92019877  DT.119679  DT.40133480  DT.91793901  DT.95150823  DT.100867319  DT.91982919 
    DT.100647180  DT.97862408  DT.121441891  DT.100647174  DT.91971358  DT.91991861  DT.101960616  DT.121441845 
    DT.97811535  DT.121441872  DT.91770899  DT.92030806  DT.92335324  DT.100893983  DT.121441853  DT.121441870 

    24/423 AceView cDNA sequences (see all 423):

    AW028755 AA417032 M24404 BM771545 BM873563 BE217951 AA354346 CD516687 
    CB112601 R71755 AI983613 AI333176 AW467799 BQ001958 BG257130 BQ029880 
    BG107750 AI743868 BG055968 AI471769 BE782875 AI572242 BF057629 AA679647 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for TCF3 (see all 21)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c · 18d ·
    SP1:                                                  -                                                                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                -     -     -     -                                                                                                         
    SP5:                                                                                                                                                            

    ExUns: 18e · 18f ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21a · 21b · 21c · 21d · 21e · 21f · 21g ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c
    SP1:                          -     -     -     -                                                                                       
    SP2:              -     -     -                                               -     -     -     -     -     -                           
    SP3:                          -     -     -     -                                                                                       
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for TCF3

    Expression
    for TCF3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTAGATGCAA
    TCF3 Expression
    About this image

    TCF3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BloodPeripheral BloodCommon Lymphoid Progenitor CellsBlood
    BloodPeripheral BloodB-cell Progenitor CellsBlood
    BloodPeripheral BloodImmature B CellsBlood
    BloodPeripheral BloodPre-B CellsBlood
    BloodPeripheral BloodPro-B CellsBlood
    KidneyAfferent ArterioleJuxtaglomerular CellsKidney, Smooth Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TCF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCF3

    SOURCE GeneReport for Unigene cluster: Hs.371282
        SABiosciences Expression via Pathway-Focused PCR Arrays including TCF3: 
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for TCF3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TCF3 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tcf31 , 5 transcription factor 31, 5 82.28(n)1
    83.93(a)1    		   10 (39.72 cM)5
    214231  NM_001164149.11  NP_001157621.11 
     804095145 
    chicken
    (Gallus gallus)    		 Aves TCF31 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) less 73.22(n)
    74.84(a)    		   395146  NM_204486.2  NP_989817.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    TCF36
    		 --
    		 78(a)
    61(a)
    		 possible ortholog
    1 ↔ 1
    		 AAWZ02036688(11541-14447)
    GL344974.1(955-13037)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC526082 hypothetical protein MGC52608 76.54(n)    X66959.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii e122 human E12 homolog 76.53(n)   30310  NM_131094.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta da3 oogenesis transcription factor 56(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea hlh-26
    		 Helix Loop Helix family member (hlh-2)
    		 22(a)
    		 1 → many
    		 I(7190846-7193914)


    ENSEMBL Gene Tree for TCF3 (if available)
    TreeFam Gene Tree for TCF3 (if available) 

    Paralogs
    for TCF3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCF3 gene
    TCF122  TCF42  
    3 SIMAP similar genes for TCF3 using alignment to 14 protein entries:     TFE2_HUMAN (see all proteins):
    E2A/PBX1 fusion    TCF12    TCF4

    TCF3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TCF3
    PGOHUM00000236370


    Genomic Variants
    for TCF3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1087 NCBI SNPs in TCF3 are shown (see all 1087)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1385658171,2
    		--1608906(+) GACTTC/TGAGCC 2 -- ds50010--------
    rs1491168431,2
    		--1608955(+) AGCCC-/GGGGGG 2 -- ds50010--------
    rs1828551231,2
    		--1608959(+) CCGGGG/TGGGGG 2 -- ds50010--------
    rs751731041,2
    		F--1608979(+) GATGGG/AGAGCC 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1874524351,2
    		--1608983(+) GGGAGC/GCCTCC 2 -- ds50010--------
    rs1918342501,2
    		--1608998(+) TGGGGA/GCTGGG 2 -- ds50010--------
    rs1840515551,2
    		--1609077(+) AGCCAA/GTCCTG 2 -- ds50010--------
    rs1870782481,2
    		--1609128(+) CCAGCC/TGCCCT 2 -- ds50010--------
    rs1922910831,2
    		--1609214(+) GCACCC/TGAGGT 2 -- ds50010--------
    rs2013443531,2
    		--1609231(+) CAGGG-/CCCCCC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for TCF3 (1609291 - 1652604 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for TCF3
         2 CNVs: 7191 73276
         1 Indel: 12011
    Human Gene Mutation Database (HGMD): TCF3

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    Disorders / Diseases
    for TCF3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TCF3 for disorders           About GeneDecksing

    OMIM gene information: 147141    OMIM disorders: --

    UniProtKB/Swiss-Prot: TFE2_HUMAN, P15923
  • Note=Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia
    • (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1. TCF3-PBX1 transforms cells by constitutively activating
    transcription of genes regulated by PBX1 or by other members of the PBX protein family. Translocation
    t(17;19)(q22;p13.3) with HLF. Inversion inv(19)(p13;q13) with TFPT

    20/45 diseases for TCF3 (see all 45):    About MalaCards
    pre-b-cell acute lymphoblastic leukemia    acute lymphoblastic leukemia    lymphoblastic leukemia    childhood leukemia
    leukemia    acute leukemia    alveolar soft part sarcoma    anaplastic large cell lymphoma
    type 2 diabetes mellitus    gastrointestinal stromal tumor    malt lymphoma    diabetes mellitus
    rheumatoid arthritis, association with    rheumatoid arthritis    chronic lymphocytic leukemia    lymphocytic leukemia
    follicular lymphoma    hemophilia    neuritis    hypercalcemia

    1 disease from the University of Copenhagen DISEASES database for TCF3:
    Leukemia

    3 Novoseek disease relationships for TCF3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoblastic leukemia acute 30.4 2 10490826 (1), 17311319 (1)
    tumors 6.54 3 12161427 (1), 17982455 (1), 17311319 (1)
    leukemia 0 2 15030166 (1), 10471746 (1)

    Genatlas disease: TCF3
    acute lymphoblastic leukemia,pre-B cell,with translocation t(1;19)(q23;p13);see PBX1


    Export disorders for TCF3 gene to outside databases

    Publications
    for TCF3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCF3 gene, integrated from 9 sources (see all 220):
    (articles sorted by number of sources associating them with TCF3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor. (PubMed id 2308859)1, 2, 3 Henthorn P.... Kadesch T. (1990)
    2. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. (PubMed id 1967983)1, 2, 3 Kamps M.P.... Baltimore D. (1990)
    3. Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. (PubMed id 14752053)1, 2 Kim J.Y....Choi H.S. (2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    5. Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary. (PubMed id 15044608)1, 2 Bayne R.A.L.... Anderson R.A. (2004)
    6. Identification of a novel molecular partner of the E2A gene in childhood leukemia. (PubMed id 10086727)1, 2 Brambillasca F.... Privitera E. (1999)
    7. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. (PubMed id 1386162)1, 2 Inaba T.... Look A.T. (1992)
    8. Sequence of a HeLa cDNA provides the DNA binding domain and carboxy terminus of HE47: a human helix-loop-helix protein related to the enhancer binding factor E47. (PubMed id 1818757)1, 2 Zhang Y. and Bina M. (1991)
    9. The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias. (PubMed id 1671560)1, 2 Hunger S.P....Cleary M.L. (1991)
    10. Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains. (PubMed id 2112746)1, 2 Voronova A. and Baltimore D. (1990)

    External Searches for TCF3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TCF3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6929 HGNC: 11633 AceView: TCF3 Ensembl:ENSG00000071564 euGenes: HUgn6929
    ECgene: TCF3 H-InvDB: TCF3

    Other Databases showing TCF3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TCF3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TCF3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TCF3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TCF3 gene:
    Search GeneIP for patents involving TCF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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