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TCF3 Gene

protein-coding GIFtS: 65

GC19M001560

transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
E2A ^¹, ², ³, ⁵
ITF1 ^¹, ², ³
MGC129647 ^¹, ²
MGC129648 ^¹, ²
TCF-3 ^³
VDIR ^¹, ²
bHLHb21 ^¹, ²

Descriptions
E2A immunoglobulin enhancer-binding factor E12/E47 ^²
Immunoglobulin enhancer-binding factor E12/E47 ^³
Immunoglobulin transcription factor 1 ^², ³
Kappa-E2-binding factor ^², ³
Transcription factor 3 ^², ³
Transcription factor ITF-1 ^³
VDR interacting repressor ^²
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) ^²
transcription factor E2-alpha ^²

External Ids
HGNC: 11633¹
Entrez Gene: 6929²
UniProtKB: P15923³
Ensembl: ENSG00000071564⁷

Search outside databases for aliases for TCF3 gene

Previous GC identifers: GC19M001671 GC19M001549

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TFE2_HUMAN, P15923

Function: Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play

major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early

B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site

in the kappa immunoglobulin gene enhancer

Gene Wiki entry for TCF3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TCF3 gene

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

TCF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M001560: (about GC identifiers)

Start:	1,560,293 bp from pter
End:	1,601,277 bp from pter
Size:	40,985 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011255.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TFE2_HUMAN, P15923 (See protein sequence)

Recommended Name: Transcription factor E2-alpha

Size: 654 amino acids; 67600 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer

with ASH1 and TWIST2. Isoform E12 interacts with GRIPE and FIGLA (By similarity). Interacts with

PTF1A and TGFB1I1. Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1

and TCF3 (By similarity). Interacts with UBE2I

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1HLH (3D)

Secondary accessions: P15883 Q14208 Q14635 Q14636 Q2TB40 Q9UPI9

Alternative splicing: 2 isoforms: P15923-1 P15923-2

Post-translational modifications:

Phosphorylated following NGF stimulation (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001129611.1 NP_003191.1

ENSEMBL proteins:

ENSP00000378813 ENSP00000262965 ENSP00000344375

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TCF3 / E2A, T Cell Factor 3 + 4)
	Human Recombinant Proteins from Abnova (TCF3)

OriGene Purified Recombinant Human Protein: TCF3

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	2493990

About this table

Antibodies for TCF3:

	Invitrogen Antibodies for TCF3
	Millipore Mono- and Polyclonal Antibodies for the study of TCF3
	Sigma-Aldrich Antibodies for TCF3
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for TCF3
	Antibodies from Abcam (TCF3 / E2A, T Cell Factor 3 + 4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TCF3)
	Novus Biologicals Antibodies for TCF3

Assays for TCF3:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of TCF3
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P15923

ProtoNet protein and cluster: P15923

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: TFE2_HUMAN, P15923

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TCF3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TCF3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001136139

Applied Biosystems Silencer® siRNAs for TCF3

Sigma-Aldrich siRNA for TCF3

Sigma-Aldrich shRNA Panels and shRNA for TCF3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001136139
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001136139
untagged cDNA clones in CMV expression vector (see all 2): NM_001136139

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003200

UniProtKB/Swiss-Prot: TFE2_HUMAN, P15923

Function: Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play

major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early

B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site

in the kappa immunoglobulin gene enhancer

Genatlas biochemistry entry for TCF3:

transcription factor 3,heterodimerizing with all myogenic bHLH vproteins and binding DNA

cooperatively with PBXs/MEISs/PKNOX1

12 MGI mutant phenotypes (inferred from 13 alleles) (MGI details for Tcf3):

cellular	growth/size	hematopoietic system	immune system	lethality-postnatal
life span-post-weaning/aging	limbs/digits/tail	nervous system	normal	renal/urinary system
reproductive system	tumorigenesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	NAS	2493990
GO:0042803	protein homodimerization activity	IDA	10958665
GO:0043425	bHLH transcription factor binding	IPI	10545951
GO:0046982	protein heterodimerization activity	NAS	2105528

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for TCF3 (Your Favorite Gene powered by Ingenuity)

Molecular Mechanisms of Cancer
Wnt/&beta
Acute Phase Response Signaling

GeneDecks TCF3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for TCF3

5/126 Interacting proteins for TCF3 (ENSP00000262965³ P15923¹) via UniProtKB, MINT, and/or STRING (see all 126 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ASCL1	P50553¹	STRING (score=.761) EBI-769630, EBI-957042
ID2	Q02363¹	STRING (score=.996) EBI-769645, EBI-713450
MYOD1	P15172¹	STRING (score=.999) EBI-769645, EBI-488878
CCNDBP1	O95273¹	EBI-769645, EBI-748961
TCF3	P15923¹	EBI-769645, EBI-769645

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002326	B cell lineage commitment	NAS	12435739
GO:0045893	positive regulation of transcription, DNA-dependent	IDA	2105528

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TCF3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TCF3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TCF3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001136139

Sigma-Aldrich siRNA for TCF3

Sigma-Aldrich shRNA Panels and shRNA for TCF3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001136139 NM_003200

REFSEQ mRNAs for TCF3 gene (2 alternative transcripts):

NM_001136139.1 NM_003200.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001136139 NM_003200

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001136139
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001136139
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001136139

Additional cDNA sequence:

AK024806.1 AK310998.1 AL117663.1 AY311345.1 BC005166.2 BC011665.2 BC014680.1 BC110580.1

EU155120.1 M24404.1 M24405.1 M31222.1 M31523.1 M65214.1 X52078.1

24/30 DOTS entries (see all 30 ):

DT.454302 DT.92019877 DT.119679 DT.91793901 DT.40133480 DT.95150823 DT.100867319 DT.91982919

DT.100647180 DT.97862408 DT.91971358 DT.121441891 DT.100647174 DT.91991861 DT.101960616 DT.121441845

DT.97811535 DT.121441872 DT.87078345 DT.91770899 DT.92030806 DT.92335324 DT.100710233 DT.102839502

24/423 AceView cDNA sequences (see all 423 ):

AW575617 BE217951 AW467799 M65214 AI379099 BE782875 AW664917 AA417032

R71755 AI202041 BQ029880 AW291864 M24404 BF342764 AW007720 AA354346

BM771545 BQ707450 R72653 CF887518 BU631013 BQ929289 AW410957 AI983613

highest scoring ESTs for TCF3:

M31523 BQ068134 BX400804 CD516687 M65214 AA176379 AA210757 AA251176 AA251379 AA284958

Unigene Cluster for TCF3:

Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)

Hs.371282 [show with all ESTs]

Unigene Representative Sequence: NM_003200

GeneLoc Exon Structure

5/21 Alternative Splicing Database (ASD) splice patterns (SP) for TCF3 (see all 21 )

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	·	17c	^	18a	·	18b	·	18c	·	18d	·
SP1:																	-
SP2:
SP3:
SP4:											-		-		-		-
SP5:

ExUns:	18e	·	18f	^	19a	·	19b	^	20a	·	20b	·	20c	·	20d	^	21a	·	21b	·	21c	·	21d	·	21e	·	21f	·	21g	^	22a	·	22b	·	22c	^	23	^	24a	·	24b	·	24c
SP1:									-		-		-		-
SP2:					-		-		-																-		-		-		-		-		-
SP3:									-		-		-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for TCF3

3 Ensembl transcripts including schematic representations:

ENST00000395423 ENST00000262965 ENST00000344749

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TCF3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TCF3

¹ / ² / ³

19 probe-sets matching TCF3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32874_at²^{, 3}	U95-A	1	1.00	1.00	0.88	0.83	M65214	0.80	1.00	0.91	1
1373_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.07	M31523	1.00	1.00	1.00	1
1374_g_at²^{, 3}	U95-A	1	1.00	1.00	0.91	1.11	M31523	1.00	1.00	1.00	1
213811_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW062341	0.20	1.00	0.72	1
209152_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI655986	0.40	1.00	0.76	1
215260_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X52078	0.60	1.00	0.82	1
213730_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE962186	0.60	1.00	0.82	1
209153_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M31523	1.00	1.00	1.00	1
209151_x_at²^{, 3}	U133-A	2	1.00	0.95	--	--	AA768906	0.60	1.00	0.82	1
210776_x_at²^{, 3}	U133-A	3	1.00	0.86	--	--	M31222	0.60	1.00	0.82	1
233358_at*²^{, 3}	U133-B	47	1.00	0.02	--	--	AK024373	0.20	0.01	0.14	3
213811_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209152_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215260_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213730_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209153_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209151_x_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
210776_x_at²	U133Plus2	3	1.00	0.86	--	--	--	--	--	--	--
233358_at*²	U133Plus2	47	1.00	0.02	--	--	--	--	--	--	--

GeneDecks TCF3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTAGATGCAA

SOURCE GeneReport for Unigene cluster: Hs.371282
Expression variation in blood from EXPOLDB for TCF3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TCF3 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TCF7L1¹	--	transcription factor 7-like 1 (T-cell specific, HMG-box)	85.68(n) 84.79(a)	485079 XM_542197.2 XP_542197.2
cow (Bos taurus)	TCF3¹	--	similar to Transcription factor E2-alpha (Immunoglobulin more	84.72(n) 85.51(a)	530616 XM_609091.3 XP_609091.3
rat (Rattus norvegicus)	Tcfe2a¹	--	transcription factor E2a	79.97(n) 80.59(a)	171046 NM_001035237.1 NP_001030314.1
mouse (Mus musculus)	Tcf3⁵ Tcfe2a¹	10 (43.00 cM)⁵	transcription factor 3⁵ transcription factor E2a¹	80.23(n)¹ 81.21(a)¹	21423¹ NM_011548.3¹ NP_035678.2¹ AA408400⁵ AB095606⁵ (see all 33)
chicken (Gallus gallus)	TCF3¹	--	transcription factor 3 (E2A immunoglobulin enhancer more	73.22(n) 74.84(a)	395146 NM_204486.2 NP_989817.2

About this table Species with no ortholog for TCF3

ENSEMBL Gene Tree for TCF3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TCF3 gene

TCF12² TCF4²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/355 NCBI SNPs in TCF3 are shown (see all 355 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 76)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs11879402^1,2	A,C,F,H	1573372(+)	`GGCGGT/CGGCAT`	2	A/T	mis¹ ese³		3		EU EA	270
	rs1052918^1,2	A,C,F	1560669(-)	`CCCCTA/GCGCCC`	2	--	ut3¹		1		MN	184
--	rs1052954^1,2	A,C,F	1560435(-)	`AAAAAA/TTTTTT`	2	--	ut3¹		1		MN	184
	rs2074888^1,2	C,H	1566796(+)	`CGGCCG/ACCGTG`	2	V/A	mis¹ ese³		2		EA	178
	rs8103100^1,2	A,C	1561362(+)	`GCTGGC/TCAGGC`	2	--	ut3¹		0	--	--	--	--
	rs35354874^1,2	C,F	1578365(-)	`CGGCCT/CGACTC`	2	P/L	mis¹		1		NA	70
	rs3746112^1,2	F,H	1561556(+)	`CTCCAG/AGGTGT`	2	--	ut3¹		5		EA EU WA	1922
--	rs1052692^1,2	C,F	1570350(-)	`TCACCG/AGCCCC`	2	S/G	mis¹ ese³		1		NA	72
--	rs11882359^1,2	C	1560267(+)	`CACCAA/GAAAGA`	1	--	ng5¹		0	--	--	--	--
	rs14990^1,2	C	1562140(-)	`TGAAAA/CTTAGC`	2	--	ut3¹		1		MN	184

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HapMap Linkage Disequilibrium images for TCF3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 147141

UniProtKB/Swiss-Prot: TFE2_HUMAN, P15923

Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute

lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1; Translocation

t(17;19)(q22;p13.3) with HLF. Inversion inv(19)(p13;q13) with TFPT

3 Novoseek disease relationships for TCF3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoblastic leukemia acute	35.00	2	10490826 (1), 17311319 (1)
tumors	0.00	3	12161427 (1), 17982455 (1), 17311319 (1)
leukemia	0.00	2	15030166 (1), 10471746 (1)

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1 PharmGKB disease relationship for TCF3 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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Genatlas disease: TCF3

acute lymphoblastic leukemia,pre-B cell,with translocation t(1;19)(q23;p13);see PBX1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/152 PubMed articles for TCF3 gene (see all 152 ):

Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor. (PubMed id 2308859)^{2, 3, 4} Henthorn P.... Kadesch T. (1990)
A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. (PubMed id 1967983)^{2, 3, 4} Kamps M.P....Baltimore D. (1990)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)
Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary. (PubMed id 15044608)^{3, 4} Bayne R.A.L.... Anderson R.A. (2004)
Identification of a novel molecular partner of the E2A gene in childhood leukemia. (PubMed id 10086727)^{3, 4} Brambillasca F.... Privitera E. (1999)
The mUBC9 murine ubiquitin conjugating enzyme interacts with the E2A transcription factors. (PubMed id 9409784)^{3, 4} Loveys D.A.... Kato G.J. (1997)
Sequence of a HeLa cDNA provides the DNA binding domain and carboxy terminus of HE47: a human helix-loop-helix protein related to the enhancer binding factor E47. (PubMed id 1818757)^{3, 4} Zhang Y. and Bina M. (1992)
Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. (PubMed id 1386162)^{3, 4} Inaba T.... Look A.T. (1992)
The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias. (PubMed id 1671560)^{3, 4} Hunger S.P....Cleary M.L. (1991)
Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains. (PubMed id 2112746)^{3, 4} Voronova A. and Baltimore D. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6929	HGNC: 11633	AceView: TCF3	Ensembl:ENSG00000071564	euGenes: HUgn6929
ECgene: TCF3	H-InvDB: TCF3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TCF3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TCF3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TCF3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TCF3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TCF3		Antibodies for TCF3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TCF3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TCF3)
	Antibodies (TCF3)
	Chimera RNAi (TCF3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for TCF3

	Recombinant Proteins (TCF3 / E2A, T Cell Factor 3 + 4)
	Antibodies (TCF3 / E2A, T Cell Factor 3 + 4)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for TCF3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TCF3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TCF3 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

TCF3 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for TCF3

Summaries
for TCF3

Genomic Location
for TCF3

Proteins
for TCF3

Protein Domains/
Families
for TCF3

Gene Function
for TCF3

Pathways & Interactions
for TCF3

Drugs & Compounds
for TCF3

Transcripts
for TCF3

Expression
for TCF3

Orthologs
for TCF3

Paralogs
for TCF3

SNPs/Variants
for TCF3

Disorders & Mutations
for TCF3

Medical News
for TCF3

Publications
for TCF3

Search for TCF3

Genome Databases showing TCF3

Other Databases showing TCF3

Specialized Databases showing TCF3

Licensable Technologies
for TCF3

Services
for TCF3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TCF3 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor TCF3

Summariesfor TCF3

Genomic Locationfor TCF3

Proteinsfor TCF3

Protein Domains/Familiesfor TCF3

Gene Functionfor TCF3

Pathways & Interactionsfor TCF3

Drugs & Compoundsfor TCF3

Transcriptsfor TCF3

Expression for TCF3

Orthologsfor TCF3

Paralogsfor TCF3

SNPs/Variantsfor TCF3

Disorders & Mutationsfor TCF3

Medical Newsfor TCF3

Publicationsfor TCF3

Search for TCF3

Genome Databases showing TCF3

Other Databases showing TCF3

Specialized Databases showing TCF3

Licensable Technologiesfor TCF3

Servicesfor TCF3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TCF3

Summaries
for TCF3

Genomic Location
for TCF3

Proteins
for TCF3

Protein Domains/
Families
for TCF3

Gene Function
for TCF3

Pathways & Interactions
for TCF3

Drugs & Compounds
for TCF3

Transcripts
for TCF3

Expression
for TCF3

Orthologs
for TCF3

Paralogs
for TCF3

SNPs/Variants
for TCF3

Disorders & Mutations
for TCF3

Medical News
for TCF3

Publications
for TCF3

Licensable Technologies
for TCF3

Services
for TCF3