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Aliases for TCF3 Gene

Aliases for TCF3 Gene

  • Transcription Factor 3 2 3 4 5
  • Immunoglobulin Transcription Factor 1 2 3 4
  • Kappa-E2-Binding Factor 2 3 4
  • Class B Basic Helix-Loop-Helix Protein 21 3 4
  • Transcription Factor E2-Alpha 2 3
  • Transcription Factor ITF-1 3 4
  • VDR Interacting Repressor 2 3
  • BHLHb21 3 4
  • TCF-3 3 4
  • ITF1 3 4
  • E2A 3 4
  • Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) 3
  • Negative Vitamin D Response Element-Binding Protein 3
  • E2A Immunoglobulin Enhancer-Binding Factor E12/E47 2
  • Immunoglobulin Enhancer-Binding Factor E12/E47 4
  • Vitamin D Receptor-Interacting Repressor 3
  • Transcription Factor 3 Variant 3 3
  • Helix-Loop-Helix Protein HE47 3
  • NOL1-TCF3 Fusion 3
  • AGM8 3
  • VDIR 3
  • E47 3

External Ids for TCF3 Gene

Previous GeneCards Identifiers for TCF3 Gene

  • GC19M001671
  • GC19M001549
  • GC19M001560
  • GC19M001384

Summaries for TCF3 Gene

Entrez Gene Summary for TCF3 Gene

  • This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

GeneCards Summary for TCF3 Gene

TCF3 (Transcription Factor 3) is a Protein Coding gene. Diseases associated with TCF3 include Agammaglobulinemia 8, Autosomal Dominant and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and HTLV-I infection. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is TCF12.

UniProtKB/Swiss-Prot for TCF3 Gene

  • Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5-CANNTG-3. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.

Gene Wiki entry for TCF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF3 Gene

Genomics for TCF3 Gene

Regulatory Elements for TCF3 Gene

Enhancers for TCF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F001624 0.2 ENCODE 12.7 +28.0 27979 0.2 HDAC1 CTCF ESRRA IRF2 CBX3 RAD21 YY1 ZKSCAN1 ZFHX2 POLR2A TCF3 SF3A2 ATP8B3 MIR1909 REXO1 ENSG00000267317 GC19M001626 RNU6-1223P
GH19F001608 1 Ensembl ENCODE 12.7 +43.1 43130 2.7 CTCF BCOR KLF17 ZIC2 HIC1 ZNF121 GLIS2 POLR2A GLIS1 KDM1A TCF3 ATP8B3 MIR1909 REXO1 UQCR11 GC19P001610
GH19F001603 0.8 ENCODE 12.7 +47.2 47188 3.3 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 LOC100288123 TMEM259 SF3A2 TCF3 ENSG00000267317 ATP8B3 MIR1909 REXO1 CIRBP ADAT3
GH19F001617 0.6 ENCODE 12.3 +34.3 34338 0.9 ZNF263 CTCF KLF1 MAZ PKNOX1 SP2 KLF17 ZNF16 RAD21 ZNF623 TCF3 RNU6-1223P GC19M001626
GH19F001546 1 Ensembl ENCODE 11.8 +106.2 106248 0.5 HDAC1 KLF17 ZNF2 RAD21 ZEB1 SCRT2 ZNF143 ZNF391 CREM ZNF654 ATP8B3 MIR1909 REXO1 TCF3 PCSK4 REEP6 C19orf25 RNU6-1223P DAZAP1 GAMT
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TCF3 on UCSC Golden Path with GeneCards custom track

Promoters for TCF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001417299 505 3401 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for TCF3 Gene

Chromosome:
19
Start:
1,609,290 bp from pter
End:
1,652,605 bp from pter
Size:
43,316 bases
Orientation:
Minus strand

Genomic View for TCF3 Gene

Genes around TCF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF3 Gene

Proteins for TCF3 Gene

  • Protein details for TCF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15923-TFE2_HUMAN
    Recommended name:
    Transcription factor E2-alpha
    Protein Accession:
    P15923
    Secondary Accessions:
    • P15883
    • Q14208
    • Q14635
    • Q14636
    • Q2TB39
    • Q2TB40
    • Q9UPI9

    Protein attributes for TCF3 Gene

    Size:
    654 amino acids
    Molecular mass:
    67600 Da
    Quaternary structure:
    • Forms a heterodimer with ASH1 and TWIST2. Isoform E12 interacts with RALGAPA1 and FIGLA. Efficient DNA binding requires dimerization with another bHLH protein. Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with NEUROD2, PTF1A and TGFB1I1. Forms a heterodimer with MYOG; heterodimerization enhances MYOG DNA-binding and transcriptional activities (By similarity). Homodimer. Heterodimer. Forms a heterodimer with NEUROD1; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element. Interacts with EP300 and UBE2I. Interacts with BHLHA9 (PubMed:25466284). Forms a heterodimer with ATOH8; repress transcription of TCF3 and TCF3/NEUROG3 dimer-induced transactivation of E box-dependent promoters (By similarity).
    SequenceCaution:
    • Sequence=AAA52331.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TCF3 Gene

    Alternative splice isoforms for TCF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCF3 Gene

Post-translational modifications for TCF3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TCF3 (E2A)

No data available for DME Specific Peptides for TCF3 Gene

Domains & Families for TCF3 Gene

Gene Families for TCF3 Gene

Protein Domains for TCF3 Gene

Suggested Antigen Peptide Sequences for TCF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15923

UniProtKB/Swiss-Prot:

TFE2_HUMAN :
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Domain:
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with TCF3: view

Function for TCF3 Gene

Molecular function for TCF3 Gene

GENATLAS Biochemistry:
transcription factor 3,heterodimerizing with all myogenic bHLH vproteins and binding DNA cooperatively with PBXs/MEISs/PKNOX1
UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5-CANNTG-3. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.

Gene Ontology (GO) - Molecular Function for TCF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 14576336
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 14576336
GO:0003677 DNA binding NAS 2105528
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 2493990
GO:0003713 transcription coactivator activity IDA 14752053
genes like me logo Genes that share ontologies with TCF3: view
genes like me logo Genes that share phenotypes with TCF3: view

Human Phenotype Ontology for TCF3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TCF3 Gene

MGI Knock Outs for TCF3:

Animal Model Products

Transcription Factor Targets for TCF3 Gene

Selected GeneGlobe predicted Target genes for TCF3
Targeted motifs for TCF3 Gene
HOMER Transcription Factor Regulatory Elements motif TCF3
  • Consensus sequence: ANACAGCTGC Submotif: canonical Cell Type: proBcell GEO ID: GSE21978

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TCF3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for TCF3 Gene

Localization for TCF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCF3 Gene COMPARTMENTS Subcellular localization image for TCF3 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TCF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 21828274
GO:0005634 nucleus NAS 2493990
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IDA 10775504
GO:0005737 cytoplasm IDA 21828274
genes like me logo Genes that share ontologies with TCF3: view

Pathways & Interactions for TCF3 Gene

genes like me logo Genes that share pathways with TCF3: view

SIGNOR curated interactions for TCF3 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TCF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 14576336
GO:0002326 B cell lineage commitment NAS 12435739
GO:0006351 transcription, DNA-templated IEA,IDA 10775504
GO:0006355 regulation of transcription, DNA-templated NAS 2493990
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with TCF3: view

Transcripts for TCF3 Gene

Unigene Clusters for TCF3 Gene

Transcription factor 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TCF3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCF3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c · 18d ·
SP1: -
SP2:
SP3:
SP4: - - - -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

ExUns: 18e · 18f ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21a · 21b · 21c · 21d · 21e · 21f · 21g ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c
SP1: - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4:
SP5:
SP6:
SP7:
SP8: - - - - - - -
SP9: -
SP10: - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - - -
SP13: - - - - - -
SP14: - - - - - -
SP15: - - - - - - - - -
SP16: -
SP17: - -
SP18: - - - - -
SP19: - - -
SP20: - - - - - - -
SP21:

Relevant External Links for TCF3 Gene

GeneLoc Exon Structure for
TCF3
ECgene alternative splicing isoforms for
TCF3

Expression for TCF3 Gene

mRNA expression in normal human tissues for TCF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TCF3 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCF3 Gene



Protein tissue co-expression partners for TCF3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCF3 Gene:

TCF3

SOURCE GeneReport for Unigene cluster for TCF3 Gene:

Hs.371282
genes like me logo Genes that share expression patterns with TCF3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TCF3 Gene

Orthologs for TCF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF3 34 35
  • 98.64 (n)
cow
(Bos Taurus)
Mammalia TCF3 34 35
  • 84.69 (n)
dog
(Canis familiaris)
Mammalia TCF3 34 35
  • 83.92 (n)
mouse
(Mus musculus)
Mammalia Tcf3 34 16 35
  • 79.9 (n)
rat
(Rattus norvegicus)
Mammalia Tcf3 34
  • 79.19 (n)
oppossum
(Monodelphis domestica)
Mammalia TCF3 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCF3 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCF3 34 35
  • 71.34 (n)
lizard
(Anolis carolinensis)
Reptilia TCF3 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcf3 34
  • 61.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC52608 34
zebrafish
(Danio rerio)
Actinopterygii tcf3b 34 35
  • 61.29 (n)
tcf3a 35
  • 49 (a)
OneToMany
e12 34
fruit fly
(Drosophila melanogaster)
Insecta da 36 35
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea hlh-2 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for TCF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCF3 Gene

ENSEMBL:
Gene Tree for TCF3 (if available)
TreeFam:
Gene Tree for TCF3 (if available)

Paralogs for TCF3 Gene

Paralogs for TCF3 Gene

Pseudogenes.org Pseudogenes for TCF3 Gene

genes like me logo Genes that share paralogs with TCF3: view

Variants for TCF3 Gene

Sequence variations from dbSNP and Humsavar for TCF3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs376780559 A colorectal cancer sample 1,650,226(+) CAGGC(A/G)CCATC nc-transcript-variant, reference, missense
rs879255271 Pathogenic 1,612,357(-) CGCGG(A/G)AGCGG intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense
rs879255378 Uncertain significance 1,619,219(-) GCCAC(C/G)CCGAG nc-transcript-variant, reference, missense
rs10401238 -- 1,646,606(+) GACTC(A/G)CGTGC intron-variant
rs10401459 -- 1,637,258(+) AACCG(A/G)GGACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCF3 Gene

Variant ID Type Subtype PubMed ID
dgv1971e59 CNV duplication 20981092
dgv6205n54 CNV loss 21841781
dgv6206n54 CNV loss 21841781
dgv6207n54 CNV loss 21841781
dgv6208n54 CNV gain+loss 21841781
dgv6209n54 CNV gain 21841781
esv2667087 CNV deletion 23128226
esv2717846 CNV deletion 23290073
esv2717847 CNV deletion 23290073
esv2717848 CNV deletion 23290073
esv2717849 CNV deletion 23290073
esv28953 CNV gain 19812545
esv32942 CNV gain+loss 17666407
nsv1072298 CNV deletion 25765185
nsv1121963 CNV deletion 24896259
nsv138347 CNV deletion 16902084
nsv578317 CNV loss 21841781
nsv578319 CNV gain+loss 21841781
nsv578330 CNV loss 21841781
nsv578336 CNV loss 21841781
nsv828379 CNV gain 20364138
nsv828380 CNV gain 20364138
nsv953942 CNV deletion 24416366

Variation tolerance for TCF3 Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.18; 75.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCF3 Gene

Human Gene Mutation Database (HGMD)
TCF3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF3 Gene

Disorders for TCF3 Gene

MalaCards: The human disease database

(10) MalaCards diseases for TCF3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
agammaglobulinemia 8, autosomal dominant
  • agm8
agammaglobulinemia, non-bruton type
  • autosomal agammaglobulinemia
leukemia, acute lymphoblastic 3
  • burkitt lymphoma
childhood leukemia
lymphoblastic leukemia
  • acute lymphocytic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search TCF3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TFE2_HUMAN
  • Agammaglobulinemia 8, autosomal dominant (AGM8) [MIM:616941]: A form of agammaglobulinemia, a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269 PubMed:24216514}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1. TCF3-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family (PubMed:1967983, PubMed:1671560). Translocation t(17;19)(q22;p13.3) with HLF (PubMed:1386162). Inversion inv(19)(p13;q13) with TFPT (PubMed:10086727). {ECO:0000269 PubMed:10086727, ECO:0000269 PubMed:1386162, ECO:0000269 PubMed:1671560, ECO:0000269 PubMed:1967983}.

Genatlas disease for TCF3 Gene

acute lymphoblastic leukemia,pre-B cell,with translocation t(1;19)(q23;p13);see PBX1

Relevant External Links for TCF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCF3
genes like me logo Genes that share disorders with TCF3: view

Publications for TCF3 Gene

  1. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. (PMID: 1967983) Kamps M.P. … Baltimore D. (Cell 1990) 2 3 4 64
  2. Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor. (PMID: 2308859) Henthorn P. … Kadesch T. (Nucleic Acids Res. 1990) 2 3 4 64
  3. Mutations affecting the BHLHA9 DNA-binding domain cause MSSD, mesoaxial synostotic syndactyly with phalangeal reduction, Malik-Percin type. (PMID: 25466284) Malik S. … Grzeschik K.H. (Am. J. Hum. Genet. 2014) 3 4 64
  4. A recurrent dominant negative E47 mutation causes agammaglobulinemia and BCR- B cells. (PMID: 24216514) Boisson B. … Conley M.E. (J. Clin. Invest. 2013) 3 4 64
  5. Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function. (PMID: 20217071) Pan F. … Deng H.W. (Immunogenetics 2010) 3 22 64

Products for TCF3 Gene

Sources for TCF3 Gene

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