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Aliases for TCF25 Gene

Aliases for TCF25 Gene

  • Transcription Factor 25 (Basic Helix-Loop-Helix) 2 3
  • NULP1 3 4 6
  • Nuclear Localized Protein 1 3 4
  • KIAA1049 4 6
  • TCF-25 3 4
  • Transcription Factor 25 3
  • HKIAA1049 3
  • PRO2620 3
  • FKSG26 3
  • Hulp1 3

External Ids for TCF25 Gene

Summaries for TCF25 Gene

Entrez Gene Summary for TCF25 Gene

  • TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]

GeneCards Summary for TCF25 Gene

TCF25 (Transcription Factor 25 (Basic Helix-Loop-Helix)) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for TCF25 Gene

  • May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF25 Gene

Genomics for TCF25 Gene

Genomic Location for TCF25 Gene

89,873,586 bp from pter
89,911,387 bp from pter
37,802 bases
Plus strand

Genomic View for TCF25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF25 Gene

Regulatory Elements for TCF25 Gene

Proteins for TCF25 Gene

  • Protein details for TCF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor 25
    Protein Accession:
    Secondary Accessions:
    • Q2MK75
    • Q9UPV3

    Protein attributes for TCF25 Gene

    676 amino acids
    Molecular mass:
    76667 Da
    Quaternary structure:
    • Interacts with XIAP.

neXtProt entry for TCF25 Gene

Proteomics data for TCF25 Gene at MOPED

Post-translational modifications for TCF25 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys192 and Lys231

No data available for DME Specific Peptides for TCF25 Gene

Domains for TCF25 Gene

Protein Domains for TCF25 Gene


  • The C-terminal region mediates transcriptional repression.:
    • Q9BQ70
  • Belongs to the TCF25 family.:
    • Q9BQ70
genes like me logo Genes that share domains with TCF25: view

No data available for Gene Families for TCF25 Gene

Function for TCF25 Gene

Molecular function for TCF25 Gene

UniProtKB/Swiss-Prot Function: May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.

Gene Ontology (GO) - Molecular Function for TCF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 16574069
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TCF25: view

miRNA for TCF25 Gene

miRTarBase miRNAs that target TCF25

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TCF25 Gene

Localization for TCF25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF25 Gene

Nucleus. Note=Some staining in the cytosol.

Subcellular locations from

Jensen Localization Image for TCF25 Gene COMPARTMENTS Subcellular localization image for TCF25 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 3

Gene Ontology (GO) - Cellular Components for TCF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16574069
genes like me logo Genes that share ontologies with TCF25: view

Pathways for TCF25 Gene

SuperPathways for TCF25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16574069
GO:0006351 transcription, DNA-templated IEA --
GO:0007507 heart development NAS 16574069
genes like me logo Genes that share ontologies with TCF25: view

No data available for Pathways by source for TCF25 Gene

Transcripts for TCF25 Gene

Unigene Clusters for TCF25 Gene

Transcription factor 25 (basic helix-loop-helix):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCF25 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d ^ 15 ^ 16a · 16b ^ 17a ·
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: - - - - - - - - - - - - -

ExUns: 17b ^ 18 ^ 19a · 19b ^ 20
SP1: - -
SP2: -
SP6: - -

Relevant External Links for TCF25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCF25 Gene

mRNA expression in normal human tissues for TCF25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCF25 Gene

SOURCE GeneReport for Unigene cluster for TCF25 Gene Hs.415342

mRNA Expression by UniProt/SwissProt for TCF25 Gene

Tissue specificity: In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart.
genes like me logo Genes that share expressions with TCF25: view

Orthologs for TCF25 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TCF25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TCF25 36
  • 98.81 (n)
  • 98.54 (a)
TCF25 37
  • 99 (a)
(Bos Taurus)
Mammalia TCF25 36
  • 83.9 (n)
  • 85.04 (a)
TCF25 37
  • 82 (a)
(Canis familiaris)
Mammalia TCF25 36
  • 87.08 (n)
  • 88.02 (a)
TCF25 37
  • 88 (a)
(Mus musculus)
Mammalia Tcf25 36
  • 85.9 (n)
  • 90.38 (a)
Tcf25 16
Tcf25 37
  • 90 (a)
(Monodelphis domestica)
Mammalia TCF25 37
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia TCF25 37
  • 65 (a)
(Rattus norvegicus)
Mammalia Tcf25 36
  • 86.83 (n)
  • 90.09 (a)
(Gallus gallus)
Aves TCF25 36
  • 68.38 (n)
  • 64.09 (a)
TCF25 37
  • 62 (a)
(Anolis carolinensis)
Reptilia TCF25 37
  • 60 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23789 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8047 36
tcf25 36
  • 63.65 (n)
  • 62.29 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5155 36
(Danio rerio)
Actinopterygii tcf25 36
  • 60.88 (n)
  • 60.56 (a)
tcf25 37
  • 57 (a)
wufc09e07 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005545 36
  • 55.33 (n)
  • 45.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7927 36
  • 49.63 (n)
  • 41.83 (a)
CG7927 37
  • 35 (a)
(Caenorhabditis elegans)
Secernentea K07A12.1 37
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 20 (a)
-- 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46900 36
  • 44.47 (n)
  • 31.41 (a)
(Oryza sativa)
Liliopsida Os09g0514900 36
  • 43.99 (n)
  • 30.82 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1142.01 36
  • 38.84 (n)
  • 30.8 (a)
Species with no ortholog for TCF25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCF25 Gene

Gene Tree for TCF25 (if available)
Gene Tree for TCF25 (if available)

Paralogs for TCF25 Gene

genes like me logo Genes that share paralogs with TCF25: view

No data available for Paralogs for TCF25 Gene

Variants for TCF25 Gene

Sequence variations from dbSNP and Humsavar for TCF25 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1065213 -- 89,911,350(+) GGTCC(A/C)CTGTT utr-variant-3-prime
rs1137042 -- 89,909,230(+) TAGCC(A/G)GCTGG intron-variant
rs1142657 -- 89,911,095(+) CCGAG(G/T)AAGGA reference, stop-gained, missense
rs2270460 -- 89,906,008(-) CTGGG(G/T)AGCCT intron-variant
rs2270461 -- 89,905,937(-) CGATG(A/G)GAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCF25 Gene

Variant ID Type Subtype PubMed ID
nsv428331 CNV Gain+Loss 18775914
dgv3009n71 CNV Loss 21882294
nsv907429 CNV Loss 21882294
nsv457624 CNV Loss 19166990
nsv907433 CNV Loss 21882294
dgv923e1 CNV Complex 17122850
dgv3014n71 CNV Loss 21882294
dgv3015n71 CNV Loss 21882294
nsv907441 CNV Loss 21882294
nsv9479 CNV Gain 18304495
esv1404867 CNV Deletion 17803354
nsv907442 CNV Loss 21882294
nsv907443 CNV Loss 21882294
nsv509640 CNV Insertion 20534489
nsv9481 CNV Loss 18304495
nsv512457 CNV Loss 21212237
esv2665192 CNV Deletion 23128226
esv5359 CNV Deletion 18987735
esv1230447 CNV Deletion 17803354
nsv511563 CNV Loss 21212237
nsv526347 CNV Loss 19592680
esv24531 CNV Gain 19812545
esv1411513 CNV Deletion 17803354
esv1528431 CNV Deletion 17803354

Relevant External Links for TCF25 Gene

HapMap Linkage Disequilibrium report

Disorders for TCF25 Gene

Relevant External Links for TCF25

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TCF25: view

No data available for UniProtKB/Swiss-Prot for TCF25 Gene

Publications for TCF25 Gene

  1. hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum response factor. (PMID: 16574069) Cai Z. … Wu X. (Biochem. Biophys. Res. Commun. 2006) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4
  4. Nulp1, a novel basic helix-loop-helix protein expressed broadly during early embryonic organogenesis and prominently in developing dorsal root ganglia. (PMID: 12107429) Olsson M. … Hjalt T. (Cell Tissue Res. 2002) 2 3
  5. Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein. (PMID: 18068114) Steen H. … Lindholm D. (Biochem. Biophys. Res. Commun. 2008) 3 4

Products for TCF25 Gene

Sources for TCF25 Gene

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