Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TCF25 Gene

Aliases for TCF25 Gene

  • Transcription Factor 25 2 3
  • Transcription Factor 25 (Basic Helix-Loop-Helix) 2 3 5
  • Nuclear Localized Protein 1 3 4
  • TCF-25 3 4
  • NULP1 3 4
  • HKIAA1049 3
  • KIAA1049 4
  • PRO2620 3
  • FKSG26 3
  • Hulp1 3

External Ids for TCF25 Gene

Previous GeneCards Identifiers for TCF25 Gene

  • GC16P088469
  • GC16P089939
  • GC16P075633

Summaries for TCF25 Gene

Entrez Gene Summary for TCF25 Gene

  • TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]

GeneCards Summary for TCF25 Gene

TCF25 (Transcription Factor 25) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for TCF25 Gene

  • May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF25 Gene

Genomics for TCF25 Gene

Regulatory Elements for TCF25 Gene

Promoters for TCF25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCF25 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCF25 Gene

Chromosome:
16
Start:
89,873,586 bp from pter
End:
89,911,387 bp from pter
Size:
37,802 bases
Orientation:
Plus strand

Genomic View for TCF25 Gene

Genes around TCF25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF25 Gene

Proteins for TCF25 Gene

  • Protein details for TCF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ70-TCF25_HUMAN
    Recommended name:
    Transcription factor 25
    Protein Accession:
    Q9BQ70
    Secondary Accessions:
    • Q2MK75
    • Q9UPV3

    Protein attributes for TCF25 Gene

    Size:
    676 amino acids
    Molecular mass:
    76667 Da
    Quaternary structure:
    • Interacts with XIAP.

neXtProt entry for TCF25 Gene

Proteomics data for TCF25 Gene at MOPED

Post-translational modifications for TCF25 Gene

  • Ubiquitination at Lys 192 and Lys 231
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TCF25 Gene

Domains & Families for TCF25 Gene

Protein Domains for TCF25 Gene

Suggested Antigen Peptide Sequences for TCF25 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BQ70

UniProtKB/Swiss-Prot:

TCF25_HUMAN :
  • The C-terminal region mediates transcriptional repression.
  • Belongs to the TCF25 family.
Domain:
  • The C-terminal region mediates transcriptional repression.
Family:
  • Belongs to the TCF25 family.
genes like me logo Genes that share domains with TCF25: view

No data available for Gene Families for TCF25 Gene

Function for TCF25 Gene

Molecular function for TCF25 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.

Gene Ontology (GO) - Molecular Function for TCF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 16189514
genes like me logo Genes that share ontologies with TCF25: view

Phenotypes for TCF25 Gene

genes like me logo Genes that share phenotypes with TCF25: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TCF25

miRNA for TCF25 Gene

miRTarBase miRNAs that target TCF25

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCF25 Gene

Localization for TCF25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF25 Gene

Nucleus. Note=Some staining in the cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCF25 Gene COMPARTMENTS Subcellular localization image for TCF25 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TCF25 Gene

Pathways & Interactions for TCF25 Gene

SuperPathways for TCF25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16574069
genes like me logo Genes that share ontologies with TCF25: view

No data available for Pathways by source and SIGNOR curated interactions for TCF25 Gene

Drugs & Compounds for TCF25 Gene

No Compound Related Data Available

Transcripts for TCF25 Gene

Unigene Clusters for TCF25 Gene

Transcription factor 25 (basic helix-loop-helix):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCF25 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d ^ 15 ^ 16a · 16b ^ 17a ·
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: - - - - - - - - - - - - -
SP6:
SP7:
SP8:
SP9:

ExUns: 17b ^ 18 ^ 19a · 19b ^ 20
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:

Relevant External Links for TCF25 Gene

GeneLoc Exon Structure for
TCF25
ECgene alternative splicing isoforms for
TCF25

Expression for TCF25 Gene

mRNA expression in normal human tissues for TCF25 Gene

Protein differential expression in normal tissues from HIPED for TCF25 Gene

This gene is overexpressed in Breast (17.3) and Lung (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCF25 Gene



SOURCE GeneReport for Unigene cluster for TCF25 Gene Hs.415342

mRNA Expression by UniProt/SwissProt for TCF25 Gene

Q9BQ70-TCF25_HUMAN
Tissue specificity: In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart.
genes like me logo Genes that share expression patterns with TCF25: view

Protein tissue co-expression partners for TCF25 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TCF25 Gene

Orthologs for TCF25 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TCF25 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TCF25 35
  • 83.9 (n)
  • 85.04 (a)
TCF25 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCF25 35
  • 87.08 (n)
  • 88.02 (a)
TCF25 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcf25 35
  • 85.9 (n)
  • 90.38 (a)
Tcf25 16
Tcf25 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TCF25 35
  • 98.81 (n)
  • 98.54 (a)
TCF25 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcf25 35
  • 86.83 (n)
  • 90.09 (a)
oppossum
(Monodelphis domestica)
Mammalia TCF25 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCF25 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCF25 35
  • 68.38 (n)
  • 64.09 (a)
TCF25 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCF25 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8047 35
tcf25 35
  • 63.65 (n)
  • 62.29 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23789 35
zebrafish
(Danio rerio)
Actinopterygii tcf25 35
  • 60.88 (n)
  • 60.56 (a)
wufc09e07 35
tcf25 36
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5155 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005545 35
  • 55.33 (n)
  • 45.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7927 35
  • 49.63 (n)
  • 41.83 (a)
CG7927 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K07A12.1 36
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 20 (a)
OneToOne
RQC1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46900 35
  • 44.47 (n)
  • 31.41 (a)
rice
(Oryza sativa)
Liliopsida Os09g0514900 35
  • 43.99 (n)
  • 30.82 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1142.01 35
  • 38.84 (n)
  • 30.8 (a)
Species with no ortholog for TCF25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCF25 Gene

ENSEMBL:
Gene Tree for TCF25 (if available)
TreeFam:
Gene Tree for TCF25 (if available)

Paralogs for TCF25 Gene

genes like me logo Genes that share paralogs with TCF25: view

No data available for Paralogs for TCF25 Gene

Variants for TCF25 Gene

Sequence variations from dbSNP and Humsavar for TCF25 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1137042 -- 89,909,230(+) TAGCC(A/G)GCTGG intron-variant
rs2293586 -- 89,895,986(+) TGCCC(A/G)CAGAG intron-variant
rs2270460 -- 89,906,008(-) CTGGG(G/T)AGCCT intron-variant
rs2270461 -- 89,905,937(-) CGATG(A/G)GAGCC intron-variant
rs2270462 -- 89,905,595(-) CCACA(C/T)CACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCF25 Gene

Variant ID Type Subtype PubMed ID
nsv428331 CNV Gain+Loss 18775914
dgv3009n71 CNV Loss 21882294
nsv907429 CNV Loss 21882294
nsv457624 CNV Loss 19166990
nsv907433 CNV Loss 21882294
dgv923e1 CNV Complex 17122850
dgv3014n71 CNV Loss 21882294
dgv3015n71 CNV Loss 21882294
nsv907441 CNV Loss 21882294
nsv9479 CNV Gain 18304495
esv1404867 CNV Deletion 17803354
nsv907442 CNV Loss 21882294
nsv907443 CNV Loss 21882294
nsv509640 CNV Insertion 20534489
nsv9481 CNV Loss 18304495
nsv512457 CNV Loss 21212237
esv2665192 CNV Deletion 23128226
esv5359 CNV Deletion 18987735
esv1230447 CNV Deletion 17803354
nsv511563 CNV Loss 21212237
nsv526347 CNV Loss 19592680
esv24531 CNV Gain 19812545
esv1411513 CNV Deletion 17803354
esv1528431 CNV Deletion 17803354

Variation tolerance for TCF25 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.78; 66.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCF25 Gene

HapMap Linkage Disequilibrium report
TCF25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF25 Gene

Disorders for TCF25 Gene

Relevant External Links for TCF25

Genetic Association Database (GAD)
TCF25
Human Genome Epidemiology (HuGE) Navigator
TCF25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCF25

No disorders were found for TCF25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCF25 Gene

Publications for TCF25 Gene

  1. hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum response factor. (PMID: 16574069) Cai Z. … Wu X. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 67
  2. Nulp1, a novel basic helix-loop-helix protein expressed broadly during early embryonic organogenesis and prominently in developing dorsal root ganglia. (PMID: 12107429) Olsson M. … Hjalt T. (Cell Tissue Res. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. Epigenome-wide DNA methylation in hearing ability: new mechanisms for an old problem. (PMID: 25184702) Wolber L.E. … Williams F.M. (PLoS ONE 2014) 3

Products for TCF25 Gene

Sources for TCF25 Gene

Back to Top

Content