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TCF25 Gene

protein-coding   GIFtS: 54
GCID: GC16P089939

Transcription Factor 25 (Basic Helix-Loop-Helix)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Factor 25 (Basic Helix-Loop-Helix)1 2     Hulp12
NULP12 3 5     PRO26202
Nuclear Localized Protein 12 3     hKIAA10492
TCF-252 3     Transcription Factor 252
KIAA10493 5     

External Ids:    HGNC: 291811   Entrez Gene: 229802   Ensembl: ENSG000001410027   OMIM: 6123265   UniProtKB: Q9BQ703   

Export aliases for TCF25 gene to outside databases

Previous GC identifers: GC16P088469 GC16P075633


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCF25 Gene:
TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in
embryonic development (Steen and Lindholm, 2008 (PubMed 18068114)).(supplied by OMIM, Sep 2008)

GeneCards Summary for TCF25 Gene:
TCF25 (transcription factor 25 (basic helix-loop-helix)) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: TCF25_HUMAN, Q9BQ70
Function: May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress
transcription of SRF in vitro and so may play a role in heart development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCF25 gene promoter:
         AP-1   Pax-6   Pax-2   Pax-2a   AP-2gamma   GATA-2   AP-2beta   AP-2alpha   AP-2alphaA   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCF25 promoter sequence
   Search Chromatin IP Primers for TCF25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCF25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

TCF25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCF25 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P089939:  view genomic region     (about GC identifiers)

Start:
89,939,994 bp from pter      End:
89,977,792 bp from pter
Size:
37,799 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCF25_HUMAN, Q9BQ70 (See protein sequence)
Recommended Name: Transcription factor 25  
Size: 676 amino acids; 76667 Da
Subunit: Interacts with XIAP (By similarity)
Secondary accessions: Q2MK75 Q9UPV3

Explore the universe of human proteins at neXtProt for TCF25: NX_Q9BQ70

Explore proteomics data for TCF25 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys192, Lys231
  • Modification sites at PhosphoSitePlus

  • See TCF25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055787.1  
    ENSEMBL proteins: 
     ENSP00000456803   ENSP00000263346   ENSP00000456080   ENSP00000454414   ENSP00000457329  
     ENSP00000456592   ENSP00000455611   ENSP00000456840   ENSP00000456344   ENSP00000455471  
     ENSP00000263347  

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    Cloud-Clone Corp. Proteins for TCF25

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR006994 TCF25
     IPR011990 TPR-like_helical

    Graphical View of Domain Structure for InterPro Entry Q9BQ70

    ProtoNet protein and cluster: Q9BQ70

    1 Blocks protein domain: IPB006994 Protein of unknown function DUF654

    UniProtKB/Swiss-Prot: TCF25_HUMAN, Q9BQ70
    Domain: The C-terminal region mediates transcriptional repression
    Similarity: Belongs to the TCF25 family


    Find genes that share domains with TCF25           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCF25_HUMAN, Q9BQ70
    Function: May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress
    transcription of SRF in vitro and so may play a role in heart development

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA16574069
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with TCF25           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCF25
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    miRTarBase miRNAs that target TCF25:
    hsa-mir-23a-3p (MIRT050402), hsa-mir-877-5p (MIRT037265), hsa-mir-23b-3p (MIRT046271)

    Block miRNA regulation of human, mouse, rat TCF25 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCF25_HUMAN, Q9BQ70: Nucleus. Note=Some staining in the cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion4
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16574069
    GO:0005730nucleolus ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ----

    Find genes that share ontologies with TCF25           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCF25
    Interactions:

        Search GeneGlobe Interaction Network for TCF25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for TCF25 (Q9BQ701, 2, 3 ENSP000002633464) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAT1P216731, 3, ENSP000003685724EBI-745182,EBI-711613 I2D: score=5 STRING: ENSP00000368572
    NEK2P519552, 3MINT-8263753 I2D: score=2 
    RPS10P467832, 3, ENSP000003472714MINT-8269274 I2D: score=2 STRING: ENSP00000347271
    MAGEA11P433643, ENSP000003473584I2D: score=4 STRING: ENSP00000347358
    MSNP260383I2D: score=4 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA16574069
    GO:0006351transcription, DNA-templated IEA--
    GO:0007507heart development NAS16574069

    Find genes that share ontologies with TCF25           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCF25



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TCF25 gene: 
    NM_014972.2  

    Unigene Cluster for TCF25:

    Transcription factor 25 (basic helix-loop-helix)
    Hs.415342  [show with all ESTs]
    Unigene Representative Sequence: AK095785
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000561585(uc010vpp.1) ENST00000561958 ENST00000263346(uc002fpb.2)
    ENST00000563032 ENST00000564652 ENST00000565196 ENST00000568412 ENST00000563406
    ENST00000565404 ENST00000566751 ENST00000562256(uc002fpc.2) ENST00000568409
    ENST00000568870 ENST00000562184 ENST00000563636 ENST00000566158 ENST00000570116(uc002fpd.1)
    ENST00000562193
    miRNA
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TCF25
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TCF25
      QuantiTect SYBR Green Assays in human, mouse, rat TCF25
      QuantiFast Probe-based Assays in human, mouse, rat TCF25

    Additional mRNA sequence: 

    AB028972.1 AF130092.1 AF322111.1 AK024679.1 AK095785.1 AK127949.1 AK301053.1 BC000959.1 
    BC009349.2 BC011884.2 DQ321703.1 

    Selected DOTS entries (see all 49):

    DT.100829193  DT.97762530  DT.447946  DT.95164481  DT.100876972  DT.100876982  DT.40229577  DT.120720636 
    DT.91867737  DT.100876980  DT.100876971  DT.95164476  DT.95211999  DT.100876977  DT.97810093  DT.100876989 
    DT.92410112  DT.95105563  DT.100038028  DT.95242185  DT.95114896  DT.97827770  DT.427850  DT.91749653 

    Selected AceView cDNA sequences (see all 339):

    BM805045 BQ216424 CA455417 BC009349 BU947712 AA861295 AI763342 BF352465 
    BP356743 BM545661 BU617143 BQ219129 BM664071 BU558002 BE502797 BM795004 
    BQ672869 BI259005 AA403210 CB216318 BM561216 CR589952 BQ477756 BX395561 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TCF25 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d ^ 15 ^ 16a · 16b ^ 17a ·
    SP1:                    -                                                                                   -     -                 -                 -     -   
    SP2:                                                                                                        -     -                 -                 -     -   
    SP3:                    -                             -                                                                                                         
    SP4:                                                                                                        -     -                                             
    SP5:                    -           -     -     -     -     -     -     -     -     -     -                 -     -                                             

    ExUns: 17b ^ 18 ^ 19a · 19b ^ 20
    SP1:        -     -               
    SP2:              -               
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for TCF25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCF25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCCAACT
    TCF25 Expression
    About this image


    TCF25 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Eye (Sensory Organs)
             Retina
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
    TCF25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCF25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.415342

    UniProtKB/Swiss-Prot: TCF25_HUMAN, Q9BQ70
    Tissue specificity: In the embryo, widely expressed with highest levels in brain. In the adult, highest expression
    is found in the heart

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TCF25 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcf251 , 5 transcription factor 25 (basic helix-loop-helix)1, 5 85.9(n)1
    90.38(a)1
      8 (72.10 cM)5
    668551  NM_001037878.31  NP_001032967.11 
     1233738245 
    chicken
    (Gallus gallus)
    Aves TCF251 transcription factor 25 (basic helix-loop-helix) 68.38(n)
    64.09(a)
      425450  XM_423211.4  XP_423211.3 
    lizard
    (Anolis carolinensis)
    Reptilia TCF256
    transcription factor 25 (basic helix-loop-helix)
    60(a)
    1 ↔ 1
    GL343866.1(16135-53259)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.237892 Xenopus laevis transcribed sequence with moderate similarity more 73.3(n)    CD360664.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc09e072 Transcribed sequence with weak similarity to protein more 72.43(n)    BQ450467.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79271 CG7927 49.63(n)
    41.83(a)
      38897  NM_139917.3  NP_648174.3 
    worm
    (Caenorhabditis elegans)
    Secernentea K07A12.16
    Protein K07A12.1 (K07A12.1) mRNA, complete cds
    23(a)
    1 ↔ 1
    I(8666595-8669788) WBGene00010620
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YDR333C)4 Putative protein of unknown function   --   4(1135431-1133260) 851933  NP_010620.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G469001 AT2G46900 44.47(n)
    31.41(a)
      819303  NM_130257.4  NP_566090.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g05149001 Os09g0514900 43.99(n)
    30.82(a)
      4347571  NM_001070198.1  NP_001063663.1 


    ENSEMBL Gene Tree for TCF25 (if available)
    TreeFam Gene Tree for TCF25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCF25 gene
    1 SIMAP similar gene for TCF25 using alignment to 11 protein entries:     TCF25_HUMAN (see all proteins):
    NULP1

    Find genes that share paralogs with TCF25           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCF25 (see all 1329)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
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    ----------
    rs1829489191,2
    --89938244(+) ATACAC/TAGCTC 1 -- us2k10--------
    rs728134281,2
    C,F--89938333(+) GCCTGC/TGGGAG 1 -- us2k12Minor allele frequency- T:0.03WA NA 238
    rs1455533701,2
    --89938373(+) AATCCA/CAACAC 1 -- us2k10--------
    rs795417071,2
    F--89938377(+) CAAACA/TCACAA 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs43905921,2
    C,F,A,H--89938438(+) TTCACG/AGACTC 1 -- us2k15Minor allele frequency- A:0.01EA NS WA 610
    rs1887360451,2
    --89938527(+) GCCAGC/TAATAA 1 -- us2k10--------
    rs1468031701,2
    --89938645(+) ATGAAA/GGCCCA 1 -- us2k10--------
    rs793396491,2
    C,F--89938650(+) AGCCCG/ACGTTA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1456212361,2
    --89938652(+) CCCACA/GTTAAA 1 -- us2k10--------
    rs1481767741,2
    C--89938663(+) ACCCTA/GAACCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TCF25 (89939994 - 89977792 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TCF25 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1528431CNV Deletion17803354
    esv5359CNV Deletion18987735
    esv2665192CNV Deletion23128226
    esv1411513CNV Deletion17803354
    esv1230447CNV Deletion17803354
    esv1404867CNV Deletion17803354
    nsv509640CNV Insertion20534489
    nsv907442CNV Loss21882294
    dgv3009n71CNV Loss21882294
    nsv9481CNV Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCF25
    DNA2.0 Custom Variant and Variant Library Synthesis for TCF25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 612326    OMIM disorders: --


    Find genes that share disorders with TCF25           About GenesLikeMe

    Genetic Association Database (GAD): TCF25
    Human Genome Epidemiology (HuGE) Navigator: TCF25 (2 documents)

    Export disorders for TCF25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TCF25 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with TCF25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum response factor. (PubMed id 16574069)1, 2, 3 Cai Z.... Wu X. (Biochem. Biophys. Res. Commun. 2006)
    2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    4. Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein. (PubMed id 18068114)1, 2 Steen H. and Lindholm D. (Biochem. Biophys. Res. Commun. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Nulp1, a novel basic helix-loop-helix protein expressed broadly during early embryonic organogenesis and prominently in developing dorsal root ganglia. (PubMed id 12107429)1, 3 Olsson M....Hjalt T. (Cell Tissue Res. 2002)
    7. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 22980 HGNC: 29181 AceView: KIAA1049 Ensembl:ENSG00000141002 euGenes: HUgn22980
    ECgene: TCF25 H-InvDB: TCF25

    (According to HUGE)
    About This Section

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    HUGE: KIAA1049

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TCF25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TCF25 gene:
    Search GeneIP for patents involving TCF25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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