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Aliases for TCF25 Gene

Aliases for TCF25 Gene

  • Transcription Factor 25 2 3 5
  • Transcription Factor 25 (Basic Helix-Loop-Helix) 2 3
  • Nuclear Localized Protein 1 3 4
  • TCF-25 3 4
  • NULP1 3 4
  • HKIAA1049 3
  • KIAA1049 4
  • PRO2620 3
  • FKSG26 3
  • Hulp1 3

External Ids for TCF25 Gene

Previous GeneCards Identifiers for TCF25 Gene

  • GC16P088469
  • GC16P089939
  • GC16P075633

Summaries for TCF25 Gene

Entrez Gene Summary for TCF25 Gene

  • TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]

GeneCards Summary for TCF25 Gene

TCF25 (Transcription Factor 25) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Non-Canonical Wnt Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for TCF25 Gene

  • May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.

Additional gene information for TCF25 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF25 Gene

Genomics for TCF25 Gene

Regulatory Elements for TCF25 Gene

Enhancers for TCF25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H089558 1.7 Ensembl ENCODE dbSUPER 55.4 -310.9 -310945 7.9 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 ANKRD11 AFG3L1P TCF25 ZC3H18 ENSG00000259877 ENSG00000268218 RPL13 LOC101927863 MC1R ACSF3
GH16H089993 1.6 Ensembl ENCODE dbSUPER 56.1 +121.7 121678 3.5 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A ZNF2 ZBTB7B SLC30A9 ENSG00000259877 AFG3L1P ANKRD11 MC1R TCF25 ACSF3 ZNF778 LINC00304 LOC101927863 SNORD68
GH16H089503 1.8 FANTOM5 ENCODE dbSUPER 31.1 -366.6 -366587 6.1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 AFG3L1P MC1R ANKRD11 ZC3H18 ENSG00000268218 SPG7 TCF25 LOC101927863 RPL13 ACSF3
GH16H089717 1.4 ENCODE dbSUPER 30 -152.5 -152517 7.5 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 AFG3L1P MC1R CDK10 TCF25 LOC101927863 ANKRD11 ENSG00000268218 VPS9D1 DBNDD1 VPS9D1-AS1
GH16H089920 1.3 ENCODE dbSUPER 30.3 +48.7 48704 4.2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 FOS DEK PAF1 SP3 ANKRD11 TCF25 ENSG00000259877 LINC00304 TUBB3 AFG3L1P MC1R SNORD68 ENSG00000268218 RPL13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCF25 on UCSC Golden Path with GeneCards custom track

Promoters for TCF25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000089791 230 1601 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9

Genomic Locations for TCF25 Gene

Genomic Locations for TCF25 Gene
chr16:89,873,570-89,913,627
(GRCh38/hg38)
Size:
40,058 bases
Orientation:
Plus strand
chr16:89,939,994-89,977,792
(GRCh37/hg19)

Genomic View for TCF25 Gene

Genes around TCF25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF25 Gene

Proteins for TCF25 Gene

  • Protein details for TCF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ70-TCF25_HUMAN
    Recommended name:
    Transcription factor 25
    Protein Accession:
    Q9BQ70
    Secondary Accessions:
    • Q2MK75
    • Q9UPV3

    Protein attributes for TCF25 Gene

    Size:
    676 amino acids
    Molecular mass:
    76667 Da
    Quaternary structure:
    • Interacts with XIAP.

neXtProt entry for TCF25 Gene

Post-translational modifications for TCF25 Gene

  • Ubiquitination at posLast=192192 and Lys231
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TCF25 Gene

Domains & Families for TCF25 Gene

Gene Families for TCF25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TCF25 Gene

Suggested Antigen Peptide Sequences for TCF25 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BQ70

UniProtKB/Swiss-Prot:

TCF25_HUMAN :
  • The C-terminal region mediates transcriptional repression.
  • Belongs to the TCF25 family.
Domain:
  • The C-terminal region mediates transcriptional repression.
Family:
  • Belongs to the TCF25 family.
genes like me logo Genes that share domains with TCF25: view

Function for TCF25 Gene

Molecular function for TCF25 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.

Phenotypes From GWAS Catalog for TCF25 Gene

Gene Ontology (GO) - Molecular Function for TCF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 16574069
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TCF25: view
genes like me logo Genes that share phenotypes with TCF25: view

miRNA for TCF25 Gene

miRTarBase miRNAs that target TCF25

Clone Products

  • Addgene plasmids for TCF25

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCF25 Gene

Localization for TCF25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF25 Gene

Nucleus. Note=Some staining in the cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCF25 gene
Compartment Confidence
nucleus 5
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TCF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16574069
genes like me logo Genes that share ontologies with TCF25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCF25 Gene

Pathways & Interactions for TCF25 Gene

genes like me logo Genes that share pathways with TCF25: view

Pathways by source for TCF25 Gene

2 Sino Biological pathways for TCF25 Gene

Gene Ontology (GO) - Biological Process for TCF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16574069
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007507 heart development NAS 16574069
genes like me logo Genes that share ontologies with TCF25: view

No data available for SIGNOR curated interactions for TCF25 Gene

Drugs & Compounds for TCF25 Gene

No Compound Related Data Available

Transcripts for TCF25 Gene

Unigene Clusters for TCF25 Gene

Transcription factor 25 (basic helix-loop-helix):
Representative Sequences:

Clone Products

  • Addgene plasmids for TCF25

Alternative Splicing Database (ASD) splice patterns (SP) for TCF25 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d ^ 15 ^ 16a · 16b ^ 17a ·
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: - - - - - - - - - - - - -
SP6:
SP7:
SP8:
SP9:

ExUns: 17b ^ 18 ^ 19a · 19b ^ 20
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:

Relevant External Links for TCF25 Gene

GeneLoc Exon Structure for
TCF25
ECgene alternative splicing isoforms for
TCF25

Expression for TCF25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCF25 Gene

Protein differential expression in normal tissues from HIPED for TCF25 Gene

This gene is overexpressed in Breast (17.3) and Lung (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCF25 Gene



Protein tissue co-expression partners for TCF25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCF25 Gene:

TCF25

SOURCE GeneReport for Unigene cluster for TCF25 Gene:

Hs.415342

mRNA Expression by UniProt/SwissProt for TCF25 Gene:

Q9BQ70-TCF25_HUMAN
Tissue specificity: In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart.

Evidence on tissue expression from TISSUES for TCF25 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Muscle(4.3)
  • Lung(3.3)
genes like me logo Genes that share expression patterns with TCF25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF25 Gene

Orthologs for TCF25 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TCF25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF25 33 34
  • 98.81 (n)
dog
(Canis familiaris)
Mammalia TCF25 33 34
  • 87.08 (n)
rat
(Rattus norvegicus)
Mammalia Tcf25 33
  • 86.83 (n)
mouse
(Mus musculus)
Mammalia Tcf25 33 16 34
  • 85.9 (n)
cow
(Bos Taurus)
Mammalia TCF25 33 34
  • 83.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TCF25 34
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCF25 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCF25 33 34
  • 68.38 (n)
lizard
(Anolis carolinensis)
Reptilia TCF25 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcf25 33
  • 63.65 (n)
Str.8047 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23789 33
zebrafish
(Danio rerio)
Actinopterygii tcf25 33 34
  • 60.88 (n)
wufc09e07 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5155 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005545 33
  • 55.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7927 33 34
  • 49.63 (n)
worm
(Caenorhabditis elegans)
Secernentea K07A12.1 34
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 20 (a)
OneToOne
RQC1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46900 33
  • 44.47 (n)
rice
(Oryza sativa)
Liliopsida Os09g0514900 33
  • 43.99 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1142.01 33
  • 38.84 (n)
Species where no ortholog for TCF25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCF25 Gene

ENSEMBL:
Gene Tree for TCF25 (if available)
TreeFam:
Gene Tree for TCF25 (if available)

Paralogs for TCF25 Gene

genes like me logo Genes that share paralogs with TCF25: view

No data available for Paralogs for TCF25 Gene

Variants for TCF25 Gene

Sequence variations from dbSNP and Humsavar for TCF25 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000002708 -- 89,906,280(+) CCTGC(C/T)CCCGG reference, missense
rs1000041954 -- 89,883,916(+) TGAAC(C/T)TTGAA intron-variant
rs1000059004 -- 89,901,034(+) GGGCC(C/T)GTGTT intron-variant
rs1000073767 -- 89,871,986(+) AGCCC(C/G)CAGTA upstream-variant-2KB
rs1000223486 -- 89,888,326(+) CTCAC(A/G)CCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCF25 Gene

Variant ID Type Subtype PubMed ID
nsv9481 CNV loss 18304495
nsv9479 CNV gain 18304495
nsv573839 CNV loss 21841781
nsv573825 CNV gain 21841781
nsv573816 CNV loss 21841781
nsv573813 CNV gain 21841781
nsv573812 CNV gain 21841781
nsv573811 CNV gain+loss 21841781
nsv573810 CNV loss 21841781
nsv573799 CNV gain 21841781
nsv573744 CNV loss 21841781
nsv526347 CNV loss 19592680
nsv512457 CNV loss 21212237
nsv511563 CNV loss 21212237
nsv509640 CNV insertion 20534489
nsv482951 CNV loss 15286789
nsv457624 CNV loss 19166990
nsv428331 CNV gain+loss 18775914
nsv1118366 CNV deletion 24896259
nsv1071318 CNV deletion 25765185
nsv1066499 CNV loss 25217958
esv5359 CNV loss 18987735
esv3553918 CNV deletion 23714750
esv2762221 CNV gain+loss 21179565
esv2758671 CNV loss 17122850
esv2665192 CNV deletion 23128226
esv24531 CNV gain 19812545
esv1528431 CNV deletion 17803354
esv1411513 CNV deletion 17803354
esv1404867 CNV deletion 17803354
esv1230447 CNV deletion 17803354
dgv5341n54 CNV gain+loss 21841781
dgv5340n54 CNV gain 21841781
dgv5339n54 CNV loss 21841781
dgv5338n54 CNV gain+loss 21841781
dgv5337n54 CNV gain+loss 21841781
dgv5336n54 CNV gain 21841781

Variation tolerance for TCF25 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.78; 66.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCF25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCF25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF25 Gene

Disorders for TCF25 Gene

Relevant External Links for TCF25

Genetic Association Database (GAD)
TCF25
Human Genome Epidemiology (HuGE) Navigator
TCF25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCF25

No disorders were found for TCF25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCF25 Gene

Publications for TCF25 Gene

  1. hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum response factor. (PMID: 16574069) Cai Z … Wu X (Biochemical and biophysical research communications 2006) 2 3 4 60
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 45 60
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 45 60
  4. Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein. (PMID: 18068114) Steen H … Lindholm D (Biochemical and biophysical research communications 2008) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for TCF25 Gene

  • Addgene plasmids for TCF25

Sources for TCF25 Gene

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