TCF24 Gene
protein-coding GIFtS: 33
GCID: GC08M067873
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transcription factor 24
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Aliases
for TCF24 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transcription Factor 241 2 | | BHLHa251 | | TCF-242 3 |
Export aliases for TCF24 gene to outside databasesPrevious GC identifers: GC08U900606 GC08M068037 GC08M063351 |
Summaries
for TCF24 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TCF24_HUMAN, Q7RTU0Function: Putative transcription factor (By similarity)
|
Genomic Views
for TCF24 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TCF24
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCF24
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF24 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q13.1 Ensembl cytogenetic band: 8q13.1 HGNC cytogenetic band: 8q13.1TCF24 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M067873: view genomic region
(about GC identifiers)
Start:
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67,858,736 bp from pter |
End:
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67,874,825 bp from pter |
Size:
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16,090 bases |
Orientation:
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minus strand |
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Proteins
for TCF24 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TCF24_HUMAN, Q7RTU0 (See
protein sequence)Recommended Name: Transcription factor 24 Size: 167 amino acids; 17516 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=DAA00306.1; Type=Erroneous gene model prediction;
Secondary accessions: H3BPR9Explore the universe of human proteins at neXtProt for TCF24: NX_Q7RTU0
TCF24 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001180431.1
ENSEMBL proteins: ENSP00000455444
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
TCF24 for ontologies About GeneDecksing
TCF24 Antibody Products:
Assay Products for TCF24: |
Protein
Domains /
Families
for TCF24 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCF24 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7RTU0ProtoNet protein and cluster: Q7RTU0 1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH
UniProtKB/Swiss-Prot: TCF24_HUMAN, Q7RTU0Similarity: Contains 1 bHLH (basic helix-loop-helix) domain |
Function
for TCF24 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TCF24_HUMAN, Q7RTU0Function: Putative transcription factor (By similarity)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF24 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0046983 | protein dimerization activity |
IEA | -- |
TCF24 for ontologies About GeneDecksing
|
Pathways & Interactions
for TCF24 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCF24
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
TCF24 for ontologies About GeneDecksing
|
Drugs & Compounds
for TCF24 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TCF24
Search CenterWatch for drugs/clinical trials and news about TCF24 
|
Transcripts
for TCF24 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCF24 gene: NM_001193502.1 Unigene Cluster for TCF24: Transcription factor 24 Hs.120040 [show with all ESTs]Unigene Representative Sequence: NM_0011935022 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000563496(uc022avl.1) ENST00000566129
1 DOTS entry: DT.303064
GeneLoc Exon Structure
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Expression
for TCF24 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCF24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAAGAGGTA
About this image
Genevestigator expression for TCF24
SOURCE GeneReport for Unigene cluster: Hs.120040
SABiosciences Custom PCR Arrays for TCF24
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TCF24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCF24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCF24 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF24 |
Orthologs
for TCF24 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TCF24 gene from 3/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC4295241 |
transcription factor 24-like |
70.22(n)
72(a) |
|
429524 XM_427081.3 XP_427081.3 |
lizard
(Anolis carolinensis) |
Reptilia |
TCF236 |
-- |
79(a) |
1 ↔ 1 |
4(31041179-31046090) |
zebrafish
(Danio rerio) |
Actinopterygii |
BX640462.36 |
-- |
50(a) |
1 ↔ 1 |
24(24350638-24355402) |
ENSEMBL Gene Tree for TCF24 (if available)
TreeFam Gene Tree for TCF24 (if available) |
Paralogs
for TCF24 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TCF24 gene
- NHLH12 TWIST12 TAL12 TWIST22 HAND22 TCF232 LYL12 NHLH22
- TAL22 TCF152 SCXB2 TCF212 HAND12 MSC2 SCXA2
4 SIMAP similar genes for TCF24 using alignment to 1 protein entry: TCF24_HUMAN:TCF23 HAND2 TWIST1 TCF21
TCF24 for paralogs About GeneDecksing
|
Genomic Variants
for TCF24 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TCF24 (67858736 - 67874825 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TCF24: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TCF24 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TCF24 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCF24 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TCF24) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 14516699)1, 2, 3 McLellan A.S.... Kealey T. (2002)
- Biochemical and phosphoproteomic analysis of the helix -loop-helix protein E47. (PubMed id 22354994)1 Teachenor R....Murre C. (2012)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
|
External Searches for TCF24 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TCF24 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCF24 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCF24 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TCF24 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TCF24 gene:
Search GeneIP for patents involving TCF24
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCF24 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 |
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCF24 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCF24 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF24 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCF24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCF24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCF24 |
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 |  |  |  | |
| | | | Search Tocris compounds for TCF24 |
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 | | | TCF24 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF24 |
|  |  |  | | | | Search ThermoFisher Antibodies for TCF24 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TCF24 |
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