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Aliases for TCF24 Gene

Aliases for TCF24 Gene

  • Transcription Factor 24 2 3 5
  • TCF-24 3 4
  • BHLHa25 3

External Ids for TCF24 Gene

Previous GeneCards Identifiers for TCF24 Gene

  • GC08U900606
  • GC08M068037
  • GC08M067873
  • GC08M063351

Summaries for TCF24 Gene

GeneCards Summary for TCF24 Gene

TCF24 (Transcription Factor 24) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is TCF23.

UniProtKB/Swiss-Prot for TCF24 Gene

  • Putative transcription factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF24 Gene

Genomics for TCF24 Gene

Regulatory Elements for TCF24 Gene

Enhancers for TCF24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F067061 0.6 ENCODE 5.3 -100.9 -100892 5.4 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 C8orf44 ARFGEF1 TCF24 CSPP1 COPS5
GH08F066963 0.4 ENCODE 5.2 -0.7 -651 0.2 RNF2 CBX2 EZH2 SNHG6 SNORD87 PPP1R42 CSPP1 COPS5 TCF24 LOC100288001
GH08F066922 0.7 ENCODE 5.1 +38.0 37985 5.1 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 ARFGEF1 TCF24 VCPIP1 GC08M066924 SNHG6 SNORD87
GH08F066916 0.9 Ensembl ENCODE 5 +43.7 43675 5.0 CTCF IRF2 CEBPG BMI1 ZBTB40 RAD21 RFX5 YY1 ZNF316 POLR2A CSPP1 COPS5 PPP1R42 TCF24 GC08M066923 MCMDC2
GH08F066870 0.6 ENCODE 4.9 +91.8 91838 1.3 MAX SIN3A DMAP1 ZNF384 ZBTB40 E2F1 POLR2A EGR1 ZNF143 THAP11 TCF24 MCMDC2 GC08M066923
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TCF24 on UCSC Golden Path with GeneCards custom track

Promoters for TCF24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001901819 -210 401 CTCF PKNOX1 MAZ SP3 RNF2 SUZ12 L3MBTL2 MAX SP2 RAD21

Genomic Location for TCF24 Gene

Chromosome:
8
Start:
66,946,501 bp from pter
End:
66,962,590 bp from pter
Size:
16,090 bases
Orientation:
Minus strand

Genomic View for TCF24 Gene

Genes around TCF24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF24 Gene

Proteins for TCF24 Gene

  • Protein details for TCF24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTU0-TCF24_HUMAN
    Recommended name:
    Transcription factor 24
    Protein Accession:
    Q7RTU0
    Secondary Accessions:
    • H3BPR9

    Protein attributes for TCF24 Gene

    Size:
    167 amino acids
    Molecular mass:
    17516 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.
    SequenceCaution:
    • Sequence=DAA00306.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TCF24 Gene

Post-translational modifications for TCF24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCF24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCF24 Gene

Domains & Families for TCF24 Gene

Gene Families for TCF24 Gene

Protein Domains for TCF24 Gene

Suggested Antigen Peptide Sequences for TCF24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTU0

UniProtKB/Swiss-Prot:

TCF24_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with TCF24: view

Function for TCF24 Gene

Molecular function for TCF24 Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor.

Gene Ontology (GO) - Molecular Function for TCF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with TCF24: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCF24 Gene

Localization for TCF24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF24 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCF24 Gene COMPARTMENTS Subcellular localization image for TCF24 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for TCF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCF24: view

Pathways & Interactions for TCF24 Gene

SuperPathways for TCF24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCF24: view

No data available for Pathways by source and SIGNOR curated interactions for TCF24 Gene

Transcripts for TCF24 Gene

mRNA/cDNA for TCF24 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCF24 Gene

Transcription factor 24:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCF24 Gene

No ASD Table

Relevant External Links for TCF24 Gene

GeneLoc Exon Structure for
TCF24
ECgene alternative splicing isoforms for
TCF24

Expression for TCF24 Gene

mRNA expression in normal human tissues for TCF24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCF24 Gene

This gene is overexpressed in Heart - Left Ventricle (x12.6), Testis (x9.3), and Heart - Atrial Appendage (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of TCF24 Gene:

TCF24

SOURCE GeneReport for Unigene cluster for TCF24 Gene:

Hs.120040
genes like me logo Genes that share expression patterns with TCF24: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TCF24 Gene

Orthologs for TCF24 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF24 34
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia TCF24 34
  • 87.69 (n)
dog
(Canis familiaris)
Mammalia TCF24 34 35
  • 84.83 (n)
rat
(Rattus norvegicus)
Mammalia Tcf24 34
  • 80.61 (n)
oppossum
(Monodelphis domestica)
Mammalia TCF24 35
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcf24 34 16 35
  • 78.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TCF24 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCF24 35
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TCF24 35
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta HLH54F 35
  • 16 (a)
OneToMany
Species where no ortholog for TCF24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCF24 Gene

ENSEMBL:
Gene Tree for TCF24 (if available)
TreeFam:
Gene Tree for TCF24 (if available)

Paralogs for TCF24 Gene

Paralogs for TCF24 Gene

(4) SIMAP similar genes for TCF24 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCF24: view

Variants for TCF24 Gene

Sequence variations from dbSNP and Humsavar for TCF24 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10524696 -- 66,948,706(+) TCTAT(-/CTAT/CTATCTAT)TTTTT intron-variant
rs111255695 -- 66,956,396(+) TCTTG(C/G)TCTGT intron-variant
rs111696274 -- 66,956,000(+) TGATC(A/G)TGGCT intron-variant
rs111719631 -- 66,961,235(+) CCCTC(A/G)CGGGC intron-variant
rs111868393 -- 66,962,939(+) GCGCT(A/G)GCCGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TCF24 Gene

Variant ID Type Subtype PubMed ID
nsv1115791 CNV duplication 24896259
nsv1148159 CNV duplication 26484159

Variation tolerance for TCF24 Gene

Gene Damage Index Score: 3.02; 50.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCF24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCF24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF24 Gene

Disorders for TCF24 Gene

Relevant External Links for TCF24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCF24

No disorders were found for TCF24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCF24 Gene

Publications for TCF24 Gene

  1. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PMID: 14516699) McLellan A.S. … Kealey T. (Mech. Dev. 2002) 2 3 4 64
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  3. Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. (PMID: 22354994) Teachenor R. … Murre C. (Mol. Cell. Biol. 2012) 3 64
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 64

Products for TCF24 Gene

Sources for TCF24 Gene

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