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TCF24 Gene

protein-coding   GIFtS: 31
GCID: GC08M067873

Transcription Factor 24

  Search for TCF24
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Factor 241 2
TCF-242 3
bHLHa252

External Ids:    HGNC: 322751   Entrez Gene: 1001296542   Ensembl: ENSG000002617877   UniProtKB: Q7RTU03   

Export aliases for TCF24 gene to outside databases

Previous GC identifers: GC08U900606 GC08M068037 GC08M063351


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TCF24 Gene:
TCF24 (transcription factor 24) is a protein-coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is TCF23.

UniProtKB/Swiss-Prot: TCF24_HUMAN, Q7RTU0
Function: Putative transcription factor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008183.20  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TCF24
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCF24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.1   Ensembl cytogenetic band:  8q13.1   HGNC cytogenetic band: 8q13.1

TCF24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCF24 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M067873:  view genomic region     (about GC identifiers)

Start:
67,858,736 bp from pter      End:
67,874,825 bp from pter
Size:
16,090 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TCF24_HUMAN, Q7RTU0 (See protein sequence)
Recommended Name: Transcription factor 24  
Size: 167 amino acids; 17516 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein (By similarity)
Sequence caution: Sequence=DAA00306.1; Type=Erroneous gene model prediction;
Secondary accessions: H3BPR9

Explore the universe of human proteins at neXtProt for TCF24: NX_Q7RTU0

Explore proteomics data for TCF24 at MOPED


See TCF24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001180431.1  
ENSEMBL proteins: 
 ENSP00000455444  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
bHLH: Basic helix-loop-helix proteins

1 InterPro protein domain:
 IPR011598 bHLH_dom

Graphical View of Domain Structure for InterPro Entry Q7RTU0

ProtoNet protein and cluster: Q7RTU0

1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: TCF24_HUMAN, Q7RTU0
Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


TCF24 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TCF24_HUMAN, Q7RTU0
Function: Putative transcription factor (By similarity)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0046983protein dimerization activity IEA--
     
TCF24 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TCF24_HUMAN, Q7RTU0: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

TCF24 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCF24
Interactions:

    Search GeneGlobe Interaction Network for TCF24

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--

TCF24 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TCF24 gene: 
NM_001193502.1  

Unigene Cluster for TCF24:

Transcription factor 24
Hs.120040  [show with all ESTs]
Unigene Representative Sequence: NM_001193502
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000563496(uc022avl.1) ENST00000566129
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1 DOTS entry:

DT.303064 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: ATAAGAGGTA

TCF24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TCF24 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.120040
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TCF24 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tcf241 , 5 transcription factor 241, 5 78.11(n)1
78.92(a)1
  15
1000395961  NM_001285425.11  NP_001272354.11 
 99601635 
lizard
(Anolis carolinensis)
Reptilia TCF246
transcription factor 24
61(a)
1 ↔ 1
4(31040606-31046251)
zebrafish
(Danio rerio)
Actinopterygii TCF246
transcription factor 24
51(a)
1 ↔ 1
24(24350638-24355402) ENSDARG00000086944
fruit fly
(Drosophila melanogaster)
Insecta HLH54F6
HLH54F
16(a)
1 → many
2R(13644922-13648022)


ENSEMBL Gene Tree for TCF24 (if available)
TreeFam Gene Tree for TCF24 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TCF24 gene
TCF232  TCF212  MSC2  
4 SIMAP similar genes for TCF24 using alignment to 1 protein entry:     TCF24_HUMAN:
TCF23    HAND2    TWIST1    TCF21

TCF24 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TCF24 (see all 315)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1476413201,2
C--67858290(+) GGCAGC/TAGAGT 1 -- ds50010--------
rs1422008441,2
C--67858332(+) GGTGCC/TGTGGC 1 -- ds50010--------
rs1501440791,2
C--67858353(+) AATCCC/TAGCAC 1 -- ds50010--------
rs1807561211,2
C--67858386(+) ATCAGA/TTGAGG 1 -- ds50010--------
rs1848157961,2
--67858467(+) AGGCAC/TGGTGG 1 -- ds50010--------
rs1906075851,2
--67858487(+) GTAGTC/TCCACT 1 -- ds50010--------
rs1819128201,2
--67858513(+) GACACA/GAGAAT 1 -- ds50010--------
rs1867887261,2
--67858582(+) CCTGCA/GAAACA 1 -- ds50010--------
rs345360421,2
C--67858605(+) AAAAGA/-CGCGG 1 -- ds50011Minor allele frequency- -:0.00NA 2
rs1912329121,2
--67858691(+) GCTTCA/GGTGTT 1 -- ds50010--------

HapMap Linkage Disequilibrium report for TCF24 (67858736 - 67874825 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TCF24: --
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TCF24 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TCF24)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 14516699)1, 2, 3 McLellan A.S.... Kealey T. (Mech. Dev. 2002)
  2. Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. (PubMed id 22354994)1 Teachenor R....Murre C. (Mol. Cell. Biol. 2012)
  3. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100129654 HGNC: 32275 Ensembl:ENSG00000261787 euGenes: HUgn100129654 ECgene: TCF24
H-InvDB: TCF24

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TCF24 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TCF24 gene:
Search GeneIP for patents involving TCF24

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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