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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCF24 Gene

protein-coding   GIFtS: 31
GCID: GC08M067873

Transcription Factor 24

  Search for TCF24
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcription Factor 241 2
TCF-242 3
bHLHa252

External Ids:    HGNC: 322751   Entrez Gene: 1001296542   Ensembl: ENSG000002617877   UniProtKB: Q7RTU03   

Export aliases for TCF24 gene to outside databases

Previous GC identifers: GC08U900606 GC08M068037 GC08M063351


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TCF24 Gene: 
TCF24 (transcription factor 24) is a protein-coding gene. GO annotations related to this gene include protein dimerization activity and DNA binding. An important paralog of this gene is TCF23.

UniProtKB/Swiss-Prot: TCF24_HUMAN, Q7RTU0
Function: Putative transcription factor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008183.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TCF24
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TCF24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.1   Ensembl cytogenetic band:  8q13.1   HGNC cytogenetic band: 8q13.1

TCF24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCF24 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M067873:  view genomic region     (about GC identifiers)

Start:
67,858,736 bp from pter      End:
67,874,825 bp from pter
Size:
16,090 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCF24_HUMAN, Q7RTU0 (See protein sequence)
Recommended Name: Transcription factor 24  
Size: 167 amino acids; 17516 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=DAA00306.1; Type=Erroneous gene model prediction;
Secondary accessions: H3BPR9

Explore the universe of human proteins at neXtProt for TCF24: NX_Q7RTU0

TCF24 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001180431.1  
ENSEMBL proteins: 
 ENSP00000455444  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

TCF24 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
bHLH: Basic helix-loop-helix proteins

1 InterPro protein domain:
 IPR011598 bHLH_dom

Graphical View of Domain Structure for InterPro Entry Q7RTU0

ProtoNet protein and cluster: Q7RTU0

1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: TCF24_HUMAN, Q7RTU0
Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


TCF24 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TCF24_HUMAN, Q7RTU0
Function: Putative transcription factor (By similarity)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0046983protein dimerization activity IEA--
     
TCF24 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCF24

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-dependent IEA--
GO:0006355regulation of transcription, DNA-dependent IEA--

TCF24 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TCF24

Search CenterWatch for drugs/clinical trials and news about TCF24

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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About This Section

REFSEQ mRNAs for TCF24 gene: 
NM_001193502.1  

Unigene Cluster for TCF24:

Transcription factor 24
Hs.120040  [show with all ESTs]
Unigene Representative Sequence: NM_001193502
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000563496(uc022avl.1) ENST00000566129
miRNA
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1 DOTS entry:

DT.303064 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TCF24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATAAGAGGTA
TCF24 Expression
About this image


Genevestigator expression for TCF24

SOURCE GeneReport for Unigene cluster: Hs.120040
    SABiosciences Custom PCR Arrays for TCF24
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF24

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TCF24 gene from 6/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tcf241 , 5 transcription factor 241, 5 82.42(n)1
83.03(a)1
  15
1000395961  XM_003688767.11  XP_003688815.11 
 99634085 
chicken
(Gallus gallus)
Aves LOC4295241 transcription factor 24-like 70.22(n)
72(a)
  429524  XM_427081.3  XP_427081.3 
lizard
(Anolis carolinensis)
Reptilia TCF246
Uncharacterized protein
65(a)
1 ↔ 1
4(31040606-31046251)
zebrafish
(Danio rerio)
Actinopterygii TCF246
transcription factor 24
55(a)
1 ↔ 1
24(24350638-24355402)
fruit fly
(Drosophila melanogaster)
Insecta HLH54F6
HLH54F
13(a)
1 → many
2R(13644922-13648022)
worm
(Caenorhabditis elegans)
Secernentea hlh-106
Protein HLH-10
13(a)
1 → many
V(9280702-9282154)


ENSEMBL Gene Tree for TCF24 (if available)
TreeFam Gene Tree for TCF24 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TCF24 gene
TCF232  TCF212  MSC2  
4 SIMAP similar genes for TCF24 using alignment to 1 protein entry:     TCF24_HUMAN:
TCF23    HAND2    TWIST1    TCF21

TCF24 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/315 SNPs in TCF24 are shown (see all 315)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1476413201,2
C--67858290(+) GGCAGC/TAGAGT 1 -- ds50010--------
rs1422008441,2
C--67858332(+) GGTGCC/TGTGGC 1 -- ds50010--------
rs1501440791,2
C--67858353(+) AATCCC/TAGCAC 1 -- ds50010--------
rs1807561211,2
C--67858386(+) ATCAGA/TTGAGG 1 -- ds50010--------
rs1848157961,2
--67858467(+) AGGCAC/TGGTGG 1 -- ds50010--------
rs1906075851,2
--67858487(+) GTAGTC/TCCACT 1 -- ds50010--------
rs1819128201,2
--67858513(+) GACACA/GAGAAT 1 -- ds50010--------
rs1867887261,2
--67858582(+) CCTGCA/GAAACA 1 -- ds50010--------
rs345360421,2
C--67858605(+) AAAAGA/-CGCGG 1 -- ds50011Minor allele frequency- -:0.00NA 2
rs1912329121,2
--67858691(+) GCTTCA/GGTGTT 1 -- ds50010--------

HapMap Linkage Disequilibrium report for TCF24 (67858736 - 67874825 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TCF24: --
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TCF24 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TCF24)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 14516699)1, 2, 3 McLellan A.S.... Kealey T. (2002)
  2. Biochemical and phosphoproteomic analysis of the helix -loop-helix protein E47. (PubMed id 22354994)1 Teachenor R....Murre C. (2012)
  3. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 100129654 HGNC: 32275 Ensembl:ENSG00000261787 euGenes: HUgn100129654 ECgene: TCF24
H-InvDB: TCF24

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TCF24 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TCF24 gene:
Search GeneIP for patents involving TCF24

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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