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Aliases for TCF24 Gene

Aliases for TCF24 Gene

  • Transcription Factor 24 2 3 5
  • TCF-24 3 4
  • BHLHa25 3

External Ids for TCF24 Gene

Previous GeneCards Identifiers for TCF24 Gene

  • GC08U900606
  • GC08M068037
  • GC08M067873
  • GC08M063351

Summaries for TCF24 Gene

GeneCards Summary for TCF24 Gene

TCF24 (Transcription Factor 24) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is TCF23.

UniProtKB/Swiss-Prot for TCF24 Gene

  • Putative transcription factor.

Additional gene information for TCF24 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF24 Gene

Genomics for TCF24 Gene

Regulatory Elements for TCF24 Gene

Enhancers for TCF24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H067061 1.4 ENCODE dbSUPER 5.3 -100.9 -100892 5 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ARFGEF1 C8orf44 TCF24 CSPP1 COPS5
GH08H066961 1.1 Ensembl ENCODE 5.2 +0.4 359 2 PKNOX1 ZNF777 SUZ12 MAX RAD21 GLIS2 ZNF366 POLR2A SCRT2 ZNF600 SNORD87 SNHG6 PPP1R42 CSPP1 COPS5 TCF24
GH08H066922 1.1 ENCODE 5.1 +38.0 37985 5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766 ZNF143 C8orf44 CSPP1 ARFGEF1 TCF24 VCPIP1 SNHG6 SNORD87 GC08M066924
GH08H066917 1.1 Ensembl ENCODE 5 +43.3 43276 4 RB1 BMI1 RAD21 YY1 ZNF143 ATF7 IKZF2 ZNF654 ZBTB11 CEBPB CSPP1 COPS5 PPP1R42 TCF24 GC08M066923 MCMDC2
GH08H066715 1.1 Ensembl ENCODE dbSUPER 4.8 +246.4 246376 0 CTCF PKNOX1 MAFG ZNF316 NFE2 FOS MAFK PRDM1 EMSY TCF24 SGK3 PTTG3P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCF24 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCF24 Gene

Chromosome:
8
Start:
66,946,501 bp from pter
End:
66,962,590 bp from pter
Size:
16,090 bases
Orientation:
Minus strand

Genomic View for TCF24 Gene

Genes around TCF24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF24 Gene

Proteins for TCF24 Gene

  • Protein details for TCF24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTU0-TCF24_HUMAN
    Recommended name:
    Transcription factor 24
    Protein Accession:
    Q7RTU0
    Secondary Accessions:
    • H3BPR9

    Protein attributes for TCF24 Gene

    Size:
    167 amino acids
    Molecular mass:
    17516 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.
    SequenceCaution:
    • Sequence=DAA00306.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TCF24 Gene

Post-translational modifications for TCF24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCF24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCF24 Gene

Domains & Families for TCF24 Gene

Gene Families for TCF24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCF24 Gene

Suggested Antigen Peptide Sequences for TCF24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TCF24: view

No data available for UniProtKB/Swiss-Prot for TCF24 Gene

Function for TCF24 Gene

Molecular function for TCF24 Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor.

Phenotypes From GWAS Catalog for TCF24 Gene

Gene Ontology (GO) - Molecular Function for TCF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with TCF24: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TCF24
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCF24 Gene

Localization for TCF24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF24 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCF24 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for TCF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCF24: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCF24 Gene

Pathways & Interactions for TCF24 Gene

SuperPathways for TCF24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCF24: view

No data available for Pathways by source and SIGNOR curated interactions for TCF24 Gene

Drugs & Compounds for TCF24 Gene

No Compound Related Data Available

Transcripts for TCF24 Gene

mRNA/cDNA for TCF24 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCF24 Gene

Transcription factor 24:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TCF24
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TCF24 Gene

No ASD Table

Relevant External Links for TCF24 Gene

GeneLoc Exon Structure for
TCF24
ECgene alternative splicing isoforms for
TCF24

Expression for TCF24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCF24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCF24 Gene

This gene is overexpressed in Heart - Left Ventricle (x12.6), Testis (x9.3), and Heart - Atrial Appendage (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of TCF24 Gene:

TCF24

SOURCE GeneReport for Unigene cluster for TCF24 Gene:

Hs.120040
genes like me logo Genes that share expression patterns with TCF24: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF24 Gene

Orthologs for TCF24 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF24 33
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia TCF24 33
  • 87.69 (n)
dog
(Canis familiaris)
Mammalia TCF24 33 34
  • 84.83 (n)
rat
(Rattus norvegicus)
Mammalia Tcf24 33
  • 80.61 (n)
oppossum
(Monodelphis domestica)
Mammalia TCF24 34
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcf24 33 16 34
  • 78.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TCF24 34
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCF24 34
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TCF24 34
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta HLH54F 34
  • 16 (a)
OneToMany
Species where no ortholog for TCF24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCF24 Gene

ENSEMBL:
Gene Tree for TCF24 (if available)
TreeFam:
Gene Tree for TCF24 (if available)

Paralogs for TCF24 Gene

Paralogs for TCF24 Gene

(4) SIMAP similar genes for TCF24 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCF24: view

Variants for TCF24 Gene

Sequence variations from dbSNP and Humsavar for TCF24 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000100945 -- 66,954,040(+) GTTTG(A/T)ATGTC intron-variant
rs1000552692 -- 66,953,680(+) ATATC(C/G)TGCAG intron-variant
rs1000577152 -- 66,948,542(+) TATTT(C/T)TAAAA intron-variant
rs1000952695 -- 66,958,058(+) TAATA(A/C)AATAA intron-variant
rs1001178986 -- 66,954,984(+) CTGCG(C/T)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCF24 Gene

Variant ID Type Subtype PubMed ID
nsv1115791 CNV duplication 24896259
nsv1148159 CNV duplication 26484159

Variation tolerance for TCF24 Gene

Gene Damage Index Score: 3.02; 50.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCF24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCF24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF24 Gene

Disorders for TCF24 Gene

Relevant External Links for TCF24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCF24

No disorders were found for TCF24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCF24 Gene

Publications for TCF24 Gene

  1. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PMID: 14516699) McLellan AS … Kealey T (Mechanisms of development 2002) 2 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 60
  4. Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. (PMID: 22354994) Teachenor R … Murre C (Molecular and cellular biology 2012) 3 60
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 60

Products for TCF24 Gene

Sources for TCF24 Gene

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