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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCF23 Gene

protein-coding   GIFtS: 43
GCID: GC02P027371

transcription factor 23

  Search for TCF23
in our new
 Human Malady Compendium 
Biological research products
for TCF23
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Transcription Factor 231 2     TCF-232 3
BHLHa241     Class II Basic Helix-Loop-Helix Protein TCF232
OUT1 2     BHLHA243
Class A Basic Helix-Loop-Helix Protein 242 3     

External Ids:    HGNC: 186021   Entrez Gene: 1509212   Ensembl: ENSG000001637927   OMIM: 6096355   UniProtKB: Q7RTU13   

Export aliases for TCF23 gene to outside databases

Previous GC identifers: GC02U990320 GC02P027283 GC02P027113


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCF23:
The gene encodes a member of the basic helix-loop-helix transcription factor family. Studies of the orthologous gene in
mouse have shown the encoded protein does not bind DNA but may negatively regulate other basic helix-loop-helix
factors via the formation of a functionally inactive heterodimeric complex. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: TCF23_HUMAN, Q7RTU1
Function: Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of
ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems
to play a role in the inhibition of myogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCF23 gene promoter:
         AP-1   ATF-2   NF-kappaB   HEN1   HOXA5   STAT3   c-Jun   NF-kappaB1   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCF23 promoter sequence
   Search SABiosciences Chromatin IP Primers for TCF23

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

TCF23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCF23 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P027371:  view genomic region     (about GC identifiers)

Start:
27,371,872 bp from pter      End:
27,376,378 bp from pter
Size:
4,507 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TCF23_HUMAN, Q7RTU1 (See protein sequence)
Recommended Name: Transcription factor 23  
Size: 214 amino acids; 23309 Da
Subunit: Forms inactive heterodimeric complexes with TCF3 (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: B2RNZ3

Explore the universe of human proteins at neXtProt for TCF23: NX_Q7RTU1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7RTU1

  • TCF23 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_786951.1  
    ENSEMBL proteins: 
     ENSP00000296096  

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    Uscn Proteins for TCF23

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    TCF23 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TCF23 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry Q7RTU1

    ProtoNet protein and cluster: Q7RTU1

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: TCF23_HUMAN, Q7RTU1
    Domain: Both the bHLH region and the C-terminal portion are essential for inhibitory function (By similarity)
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TCF23_HUMAN, Q7RTU1
    Function: Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of
    ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems
    to play a role in the inhibition of myogenesis (By similarity)

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046983protein dimerization activity IEA--


    TCF23 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency1.00
    Factors Promoting Cardiogenesis in Vertebrates0.50
    2Rho Family GTPases
    MAPK Signaling0.51
    ILK Signaling0.45
    3WNT Signaling
    WNT Signaling1.00
    4TGF-Beta Pathway
    JNK Pathway0.50
    5PAK Pathway
    Epithelial Adherens Junctions0.36

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCF23 (see all 7)
        MAPK Signaling
    ILK Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Human Embryonic Stem Cell Pluripotency
    JNK Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCF23

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TCF23 (Q7RTU13 ENSP000002960964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCF12Q990813, ENSP000003310574I2D: score=1 STRING: ENSP00000331057
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007517muscle organ development IEA--
    GO:0030154cell differentiation IEA--


    TCF23 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCF23
    Search CenterWatch for drugs/clinical trials and news about TCF23 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCF23 gene: 
    NM_175769.2  

    Unigene Cluster for TCF23:

    Transcription factor 23
    Hs.591583  [show with all ESTs]
    Unigene Representative Sequence: NM_175769
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296096(uc010ylg.2) ENST00000407815

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    Inhib. RNA
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    Additional cDNA sequence: 

    BC137191.1 BC137192.1 BC144525.1 

    1 DOTS entry:

    DT.120958737 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCF23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCAGGGGTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    TCF23 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TCF23 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.591583

    UniProtKB/Swiss-Prot: TCF23_HUMAN, Q7RTU1
    Tissue specificity: Expressed in liver, kidney and spleen

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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TCF23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TCF23 gene from 1/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii tcf236
    transcription factor 23
    43(a)
    1 ↔ 1
    6(8069004-8074995)


    ENSEMBL Gene Tree for TCF23 (if available)
    TreeFam Gene Tree for TCF23 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCF23 gene
    TCF242  NHLH12  TWIST12  TAL12  TWIST22  HAND22  LYL12  NHLH22  
    TAL22  TCF152  SCXB2  TCF212  HAND12  MSC2  SCXA2  
    1 SIMAP similar gene for TCF23 using alignment to 1 protein entry:     TCF23_HUMAN:
    TCF24

    TCF23 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/113 NCBI SNPs in TCF23 are shown (see all 113    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs746790181,2
    F,--27369989(+) CTGTCA/CTTATT 1 -- us2k11Minor allele frequency- C:0.18WA 118
    rs1395767141,2
    --27370045(+) TTTAAC/TGACTT 1 -- us2k10--------
    rs1442052061,2
    --27370078(+) TGTTTA/CTACTA 1 -- us2k10--------
    rs1835380941,2
    --27370092(+) TACCTA/TCCTTT 1 -- us2k10--------
    rs1870387331,2
    --27370093(+) ACCTAC/TCTTTC 1 -- us2k10--------
    rs570934971,2
    C--27370115(+) CCTTC-/CTTC  
            
    TTTTT
    1 -- us2k11Minor allele frequency- CTTC:0.00NA 2
    rs667502781,2
    C,--27370115(+) CTTTG-/CTTC  
            
    CTTCC
    1 -- us2k10--------
    rs1465619461,2
    --27370154(+) CAAGAC/GCGTGT 1 -- us2k10--------
    rs12755161,2
    C,F,A,H,--27370162(-) AGAGCG/AAGACA 1 -- us2k19Minor allele frequency- A:0.01NA WA CSA EA 135
    rs1910792961,2
    --27370204(+) TTGGCC/TCACTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TCF23 (27371872 - 27376378 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TCF23
         1 CNV: 9399

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TCF23 for disorders           About MalaCards

    TCF23 for disorders           About GeneDecksing

    OMIM gene information: 609635    OMIM disorders: --


    Export disorders for TCF23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCF23 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TCF23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and chromosomal mapping of the basic helix-loop-helix factor OUT (Tcf23/TCF23). (PubMed id 11701948)1, 3, 9 Tachibana M....Yokota Y. (2001)
    2. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 14516699)1, 2 McLellan A.S.... Kealey T. (2002)
    3. OUT, a novel basic helix-loop-helix transcription factor with an Id-like inhibitory activity. (PubMed id 10652346)1, 3 Narumi O....Yokota Y. (2000)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Identification of transcription factors at the site of implantation in the later stages of murine pregnancy. (PubMed id 16514199)9 Zhao B....Bethin K.E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 150921 HGNC: 18602 Ensembl:ENSG00000163792 euGenes: HUgn150921 ECgene: TCF23
    H-InvDB: TCF23

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCF23 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCF23 gene:
    Search GeneIP for patents involving TCF23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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