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Aliases for TCF23 Gene

Aliases for TCF23 Gene

  • Transcription Factor 23 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 24 3 4
  • BHLHa24 3 4
  • TCF-23 3 4
  • Class II Basic Helix-Loop-Helix Protein TCF23 3
  • OUT 3

External Ids for TCF23 Gene

Previous GeneCards Identifiers for TCF23 Gene

  • GC02U990320
  • GC02P027283
  • GC02P027371
  • GC02P027113

Summaries for TCF23 Gene

Entrez Gene Summary for TCF23 Gene

  • The gene encodes a member of the basic helix-loop-helix transcription factor family. Studies of the orthologous gene in mouse have shown the encoded protein does not bind DNA but may negatively regulate other basic helix-loop-helix factors via the formation of a functionally inactive heterodimeric complex. [provided by RefSeq, May 2010]

GeneCards Summary for TCF23 Gene

TCF23 (Transcription Factor 23) is a Protein Coding gene. Among its related pathways are ERK Signaling and PAK Pathway. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is TCF24.

UniProtKB/Swiss-Prot for TCF23 Gene

  • Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF23 Gene

Genomics for TCF23 Gene

Regulatory Elements for TCF23 Gene

Genomic Location for TCF23 Gene

Chromosome:
2
Start:
27,148,933 bp from pter
End:
27,156,974 bp from pter
Size:
8,042 bases
Orientation:
Plus strand

Genomic View for TCF23 Gene

Genes around TCF23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF23 Gene

Proteins for TCF23 Gene

  • Protein details for TCF23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTU1-TCF23_HUMAN
    Recommended name:
    Transcription factor 23
    Protein Accession:
    Q7RTU1
    Secondary Accessions:
    • B2RNZ3

    Protein attributes for TCF23 Gene

    Size:
    214 amino acids
    Molecular mass:
    23309 Da
    Quaternary structure:
    • Forms inactive heterodimeric complexes with TCF3.

neXtProt entry for TCF23 Gene

Proteomics data for TCF23 Gene at MOPED

Post-translational modifications for TCF23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCF23 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCF23 Gene

Domains & Families for TCF23 Gene

Gene Families for TCF23 Gene

Protein Domains for TCF23 Gene

Suggested Antigen Peptide Sequences for TCF23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTU1

UniProtKB/Swiss-Prot:

TCF23_HUMAN :
  • Both the bHLH region and the C-terminal portion are essential for inhibitory function.
Domain:
  • Both the bHLH region and the C-terminal portion are essential for inhibitory function.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with TCF23: view

Function for TCF23 Gene

Molecular function for TCF23 Gene

UniProtKB/Swiss-Prot Function:
Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity).
genes like me logo Genes that share phenotypes with TCF23: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCF23 Gene

Localization for TCF23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF23 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCF23 Gene COMPARTMENTS Subcellular localization image for TCF23 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for TCF23 Gene

Pathways & Interactions for TCF23 Gene

genes like me logo Genes that share pathways with TCF23: view

Gene Ontology (GO) - Biological Process for TCF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007517 muscle organ development IEA --
genes like me logo Genes that share ontologies with TCF23: view

No data available for SIGNOR curated interactions for TCF23 Gene

Drugs & Compounds for TCF23 Gene

No Compound Related Data Available

Transcripts for TCF23 Gene

mRNA/cDNA for TCF23 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCF23 Gene

Transcription factor 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCF23 Gene

No ASD Table

Relevant External Links for TCF23 Gene

GeneLoc Exon Structure for
TCF23
ECgene alternative splicing isoforms for
TCF23

Expression for TCF23 Gene

mRNA expression in normal human tissues for TCF23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCF23 Gene

This gene is overexpressed in Uterus (x22.0), Fallopian Tube (x16.5), and Ovary (x7.0).

Protein differential expression in normal tissues from HIPED for TCF23 Gene

This gene is overexpressed in Lung (56.1) and Fetal Brain (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCF23 Gene



SOURCE GeneReport for Unigene cluster for TCF23 Gene Hs.591583

mRNA Expression by UniProt/SwissProt for TCF23 Gene

Q7RTU1-TCF23_HUMAN
Tissue specificity: Expressed in liver, kidney and spleen.
genes like me logo Genes that share expression patterns with TCF23: view

Protein tissue co-expression partners for TCF23 Gene

Primer Products

In Situ Assay Products

Orthologs for TCF23 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TCF23 35
  • 83.96 (n)
  • 78.97 (a)
TCF23 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCF23 35
  • 84.58 (n)
  • 76.64 (a)
TCF23 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcf23 35
  • 82.78 (n)
  • 78.95 (a)
Tcf23 16
Tcf23 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TCF23 35
  • 100 (n)
  • 100 (a)
TCF23 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcf23 35
  • 80.61 (n)
  • 75.48 (a)
oppossum
(Monodelphis domestica)
Mammalia TCF23 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCF23 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tcf23 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta HLH54F 36
  • 18 (a)
OneToMany
Species with no ortholog for TCF23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCF23 Gene

ENSEMBL:
Gene Tree for TCF23 (if available)
TreeFam:
Gene Tree for TCF23 (if available)

Paralogs for TCF23 Gene

Paralogs for TCF23 Gene

(1) SIMAP similar genes for TCF23 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCF23: view

Variants for TCF23 Gene

Sequence variations from dbSNP and Humsavar for TCF23 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11126879 - 27,149,207(+) AGCAC(A/G)GTTGC reference, missense
VAR_038326 -
rs737420 -- 27,148,968(+) CCTGG(G/T)GGGCG upstream-variant-2KB, utr-variant-5-prime
rs1275507 -- 27,152,324(-) CAAGG(A/T)TTGCC intron-variant
rs1275508 -- 27,151,551(-) tttga(G/T)accaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCF23 Gene

Variant ID Type Subtype PubMed ID
nsv817673 CNV Gain 17921354
nsv833603 CNV Loss 17160897
nsv482050 CNV Gain 20164927

Variation tolerance for TCF23 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCF23 Gene

HapMap Linkage Disequilibrium report
TCF23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF23 Gene

Disorders for TCF23 Gene

Relevant External Links for TCF23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCF23

No disorders were found for TCF23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCF23 Gene

Publications for TCF23 Gene

  1. Genomic organization and chromosomal mapping of the basic helix-loop-helix factor OUT (Tcf23/TCF23). (PMID: 11701948) Tachibana M. … Yokota Y. (Cytogenet. Cell Genet. 2001) 2 3 23 67
  2. OUT, a novel basic helix-loop-helix transcription factor with an Id-like inhibitory activity. (PMID: 10652346) Narumi O. … Yokota Y. (J. Biol. Chem. 2000) 2 3
  3. A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells. (PMID: 24571987) Kommagani R. … Lydon J.P. (Biol. Reprod. 2014) 3
  4. Identification of transcription factors at the site of implantation in the later stages of murine pregnancy. (PMID: 16514199) Zhao B. … Bethin K.E. (Reproduction 2006) 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TCF23 Gene

Sources for TCF23 Gene

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