Aliases for TCF23 Gene
External Ids for TCF23 Gene
Previous GeneCards Identifiers for TCF23 Gene
The gene encodes a member of the basic helix-loop-helix transcription factor family. Studies of the orthologous gene in mouse have shown the encoded protein does not bind DNA but may negatively regulate other basic helix-loop-helix factors via the formation of a functionally inactive heterodimeric complex. [provided by RefSeq, May 2010]
GeneCards Summary for TCF23 Gene
TCF23 (Transcription Factor 23) is a Protein Coding gene. Diseases associated with TCF23 include atrioventricular block. Among its related pathways are ERK Signaling and PAK Pathway. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is TCF24.
UniProtKB/Swiss-Prot for TCF23 Gene
Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity).