TCF23 Gene
protein-coding GIFtS : 43
GCID: GC02 P027371
transcription factor 23
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Aliasesfor TCF23 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Transcription Factor 23 1 2 TCF-232 3 BHLHa241 Class II Basic Helix-Loop-Helix Protein TCF232 OUT1 2 BHLHA243 Class A Basic Helix-Loop-Helix Protein 242 3
Export aliases for TCF23 gene to outside databases Previous GC identifers: GC02U990320 GC02P027283 GC02P027113
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Summariesfor TCF23 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for TCF23 : The gene encodes a member of the basic helix-loop-helix transcription factor family. Studies of the orthologous gene in mouse have shown the encoded protein does not bind DNA but may negatively regulate other basic helix-loop-helix factors via the formation of a functionally inactive heterodimeric complex. (provided by RefSeq, May 2010) UniProtKB/Swiss-Prot: TCF23_HUMAN, Q7RTU1 Function : Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that ofID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity)
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Genomic Viewsfor TCF23 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_022184.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TCF23 gene promoter: AP-1 ATF-2 NF-kappaB HEN1 HOXA5 STAT3 c-Jun NF-kappaB1 AP-2alpha Other transcription factors Search SABiosciences Chromatin IP Primers for TCF23 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF23
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3 TCF23 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P027371: view genomic region
(about GC identifiers )
Start:
27,371,872 bp from pter
End:
27,376,378 bp from pter
Size:
4,507 bases
Orientation:
plus strand
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Proteinsfor TCF23 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TCF23_HUMAN, Q7RTU1 (See
protein sequence )Recommended Name: Transcription factor 23 Size : 214 amino acids; 23309 Da
Subunit : Forms inactive heterodimeric complexes with TCF3 (By similarity)
Subcellular location : Nucleus (By similarity)
Secondary accessions : B2RNZ3Explore the universe of human proteins at neXtProt for TCF23: NX_Q7RTU1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q7RTU1 TCF23 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_786951.1 ENSEMBL proteins: ENSP00000296096 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
TCF23 for ontologies About GeneDecksing TCF23 Antibody Products: Assay Products for TCF23:
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Protein
Domains / Familiesfor TCF23 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TCF23 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q7RTU1 ProtoNet protein and cluster: Q7RTU1
1 Blocks protein family : IPB001092 Basic helix-loop-helix dimerization domain bHLH UniProtKB/Swiss-Prot: TCF23_HUMAN, Q7RTU1 Domain : Both the bHLH region and the C-terminal portion are essential for inhibitory function (By similarity)Similarity : Contains 1 bHLH (basic helix-loop-helix) domain
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Functionfor TCF23 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TCF23_HUMAN, Q7RTU1 Function : Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that ofID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TCF23 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TCF23OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TCF23 (NM_175769 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCF23 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TCF23
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0046983 protein dimerization activity
IEA --
TCF23 for ontologies About GeneDecksing
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Pathways & Interactionsfor TCF23 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Human Embryonic Stem Cell Pluripotency 2 Rho Family GTPases 3 WNT Signaling 4 TGF-Beta Pathway 5 PAK Pathway
5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCF23 (see all 7 )Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCF23 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for TCF23 (Q7RTU1 3 ENSP00000296096 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007517 muscle organ development
IEA -- GO:0030154 cell differentiation
IEA --
TCF23 for ontologies About GeneDecksing
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Drugs & Compoundsfor TCF23 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TCF23 Search CenterWatch for drugs/clinical trials and news about TCF23
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Transcriptsfor TCF23 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TCF23 gene: NM_175769.2 Unigene Cluster for TCF23:
Transcription factor 23 Hs.591583 [show with all ESTs ] Unigene Representative Sequence: NM_175769 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000296096 (uc010ylg.2 ) ENST00000407815 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TCF23 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TCF23OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TCF23 (NM_175769 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCF23 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TCF23
Additional cDNA sequence: BC137191.1 BC137192.1 BC144525.1
1 DOTS entry : DT.120958737
GeneLoc Exon Structure
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Expression for TCF23 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TCF23 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCAGGGGTGG
About this image TCF23 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See TCF23 Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.591583 UniProtKB/Swiss-Prot: TCF23_HUMAN, Q7RTU1 Tissue specificity : Expressed in liver, kidney and spleen SABiosciences Custom PCR Arrays for TCF23 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TCF23Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TCF23 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TCF23 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TCF23
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Orthologsfor TCF23 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for TCF23 gene from 1/11 species (see all 11 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
zebrafish (Danio rerio)
Actinopterygii
tcf236
transcription factor 23
43(a)
1 ↔ 1
6(8069004-8074995)
ENSEMBL Gene Tree for TCF23 (if available)TreeFam Gene Tree for TCF23 (if available)
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Paralogsfor TCF23 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TCF23 gene TCF24 2 NHLH1 2 TWIST1 2 TAL1 2 TWIST2 2 HAND2 2 LYL1 2 NHLH2 2 TAL2 2 TCF15 2 SCXB 2 TCF21 2 HAND1 2 MSC 2 SCXA 2 1 SIMAP similar gene for TCF23 using alignment to 1 protein entry: TCF23_HUMAN :TCF24
TCF23 for paralogs About GeneDecksing
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Genomic Variantsfor TCF23 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 2 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TCF23 (27371872 - 27376378 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for TCF23 1 CNV : 9399
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TCF23
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Disorders
/ Diseasesfor TCF23 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TCF23 for disorders About MalaCards
TCF23 for disorders About GeneDecksing
OMIM gene information: 609635
OMIM disorders : --Export disorders for TCF23 gene to outside databases
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Publicationsfor TCF23 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TCF23 gene integrated from 9 sources : (articles sorted by number of sources associating them with TCF23) Utopia : connect your pdf to the dynamic world of online information
Genomic organization and chromosomal mapping of the basic helix-loop-helix factor OUT (Tcf23/TCF23). (PubMed id 11701948) 1 , 3, 9 Tachibana M....Yokota Y. (2001) Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 14516699) 1 , 2 McLellan A.S.... Kealey T. (2002) OUT, a novel basic helix-loop-helix transcription factor with an Id-like inhibitory activity. (PubMed id 10652346) 1 , 3 Narumi O....Yokota Y. (2000) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 2 Hillier L.W....Wilson R.K. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Identification of transcription factors at the site of implantation in the later stages of murine pregnancy. (PubMed id 16514199) 9 Zhao B....Bethin K.E. (2006)
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External Searches for TCF23 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TCF23 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TCF23 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TCF23 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TCF23 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TCF23 gene: Search GeneIP for patents involving TCF23 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TCF23 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TCF23 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TCF23 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TCF23 OriGene Protein Over-expression Lysate for TCF23 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TCF23 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TCF23 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TCF23 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for TCF23 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TCF23 OriGene Custom Protein Services for TCF23 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCF23 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TCF23 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF23 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TCF23 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TCF23 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TCF23
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TCF23 Proteins, Antibodies, CLIAs, and ELISAs
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TCF23
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