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Aliases for TCF23 Gene

Aliases for TCF23 Gene

  • Transcription Factor 23 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 24 3 4
  • BHLHa24 3 4
  • TCF-23 3 4
  • Class II Basic Helix-Loop-Helix Protein TCF23 3
  • OUT 3

External Ids for TCF23 Gene

Previous GeneCards Identifiers for TCF23 Gene

  • GC02U990320
  • GC02P027283
  • GC02P027371
  • GC02P027113

Summaries for TCF23 Gene

Entrez Gene Summary for TCF23 Gene

  • The gene encodes a member of the basic helix-loop-helix transcription factor family. Studies of the orthologous gene in mouse have shown the encoded protein does not bind DNA but may negatively regulate other basic helix-loop-helix factors via the formation of a functionally inactive heterodimeric complex. [provided by RefSeq, May 2010]

GeneCards Summary for TCF23 Gene

TCF23 (Transcription Factor 23) is a Protein Coding gene. Among its related pathways are PAK Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include protein dimerization activity. An important paralog of this gene is TCF24.

UniProtKB/Swiss-Prot for TCF23 Gene

  • Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity).

Additional gene information for TCF23 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF23 Gene

Genomics for TCF23 Gene

GeneHancer (GH) Regulatory Elements for TCF23 Gene

Promoters and enhancers for TCF23 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I027148 Promoter 0.7 EPDnew 550.8 +0.1 76 0.1 ZFHX2 EGR1 EGR2 TCF23 ENSG00000236099 GC02P027132
GH02I027122 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.5 -25.3 -25268 1.7 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ATF7 SP3 ABHD1 TCF23 ATRAID SLC5A6 KHK EMILIN1 CAD CENPA SLC35F6 CGREF1
GH02I027263 Promoter 1.5 EPDnew Ensembl 10.6 +114.2 114168 0.2 CTCF SUZ12 ZNF335 CCNT2 E2F1 ZFHX2 GLIS2 POLR2A PATZ1 ZBTB20 SLC30A3 UCN MPV17 CAD ATRAID SLC5A6 GTF3C2-AS1 TCF23 GTF3C2 PRR30
GH02I027090 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.9 -55.0 -55018 6.6 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF143 KHK CGREF1 ABHD1 ATRAID SLC5A6 CAD PRR30 TCF23 PREB AGBL5-AS1
GH02I027169 Enhancer 1.2 Ensembl ENCODE 12.4 +22.3 22335 2.9 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 ARID2 ZNF143 ATRAID GTF3C2 TCF23 PRR30 PREB SLC5A6 ABHD1 CAD SLC30A3 DNAJC5G
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCF23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCF23 gene promoter:

Genomic Locations for TCF23 Gene

Genomic Locations for TCF23 Gene
chr2:27,148,933-27,156,974
(GRCh38/hg38)
Size:
8,042 bases
Orientation:
Plus strand
chr2:27,371,872-27,376,378
(GRCh37/hg19)

Genomic View for TCF23 Gene

Genes around TCF23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF23 Gene

Proteins for TCF23 Gene

  • Protein details for TCF23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTU1-TCF23_HUMAN
    Recommended name:
    Transcription factor 23
    Protein Accession:
    Q7RTU1
    Secondary Accessions:
    • B2RNZ3

    Protein attributes for TCF23 Gene

    Size:
    214 amino acids
    Molecular mass:
    23309 Da
    Quaternary structure:
    • Forms inactive heterodimeric complexes with TCF3.

neXtProt entry for TCF23 Gene

Post-translational modifications for TCF23 Gene

No Post-translational modifications

Other Protein References for TCF23 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCF23 Gene

Domains & Families for TCF23 Gene

Gene Families for TCF23 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TCF23 Gene

Suggested Antigen Peptide Sequences for TCF23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTU1

UniProtKB/Swiss-Prot:

TCF23_HUMAN :
  • Both the bHLH region and the C-terminal portion are essential for inhibitory function.
Domain:
  • Both the bHLH region and the C-terminal portion are essential for inhibitory function.
genes like me logo Genes that share domains with TCF23: view

Function for TCF23 Gene

Molecular function for TCF23 Gene

UniProtKB/Swiss-Prot Function:
Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for TCF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with TCF23: view
genes like me logo Genes that share phenotypes with TCF23: view

miRNA for TCF23 Gene

miRTarBase miRNAs that target TCF23

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCF23 Gene

Localization for TCF23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCF23 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TCF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCF23: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCF23 Gene

Pathways & Interactions for TCF23 Gene

genes like me logo Genes that share pathways with TCF23: view

Gene Ontology (GO) - Biological Process for TCF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007517 muscle organ development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TCF23: view

No data available for SIGNOR curated interactions for TCF23 Gene

Drugs & Compounds for TCF23 Gene

No Compound Related Data Available

Transcripts for TCF23 Gene

mRNA/cDNA for TCF23 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCF23 Gene

Transcription factor 23:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCF23 Gene

No ASD Table

Relevant External Links for TCF23 Gene

GeneLoc Exon Structure for
TCF23
ECgene alternative splicing isoforms for
TCF23

Expression for TCF23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCF23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCF23 Gene

This gene is overexpressed in Uterus (x22.0), Fallopian Tube (x16.5), and Ovary (x7.0).

Protein differential expression in normal tissues from HIPED for TCF23 Gene

This gene is overexpressed in Lung (56.1) and Fetal Brain (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCF23 Gene



Protein tissue co-expression partners for TCF23 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCF23 Gene:

TCF23

SOURCE GeneReport for Unigene cluster for TCF23 Gene:

Hs.591583

mRNA Expression by UniProt/SwissProt for TCF23 Gene:

Q7RTU1-TCF23_HUMAN
Tissue specificity: Expressed in liver, kidney and spleen.
genes like me logo Genes that share expression patterns with TCF23: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF23 Gene

Orthologs for TCF23 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF23 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia TCF23 33 34
  • 84.58 (n)
cow
(Bos Taurus)
Mammalia TCF23 33 34
  • 83.96 (n)
mouse
(Mus musculus)
Mammalia Tcf23 33 16 34
  • 82.78 (n)
rat
(Rattus norvegicus)
Mammalia Tcf23 33
  • 80.61 (n)
oppossum
(Monodelphis domestica)
Mammalia TCF23 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCF23 34
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tcf23 34
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta HLH54F 34
  • 18 (a)
OneToMany
Species where no ortholog for TCF23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCF23 Gene

ENSEMBL:
Gene Tree for TCF23 (if available)
TreeFam:
Gene Tree for TCF23 (if available)

Paralogs for TCF23 Gene

Paralogs for TCF23 Gene

(1) SIMAP similar genes for TCF23 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCF23: view

Variants for TCF23 Gene

Sequence variations from dbSNP and Humsavar for TCF23 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000988473 -- 27,153,233(+) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1001266350 -- 27,153,303(+) A/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1001321785 -- 27,151,500(+) A/C intron_variant
rs1001405786 -- 27,146,921(+) G/A upstream_transcript_variant
rs1002772132 -- 27,152,985(+) C/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TCF23 Gene

Variant ID Type Subtype PubMed ID
dgv6744n54 CNV loss 21841781
nsv482050 CNV gain 20164927
nsv817673 CNV gain 17921354
nsv833603 CNV loss 17160897

Variation tolerance for TCF23 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCF23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCF23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF23 Gene

Disorders for TCF23 Gene

Additional Disease Information for TCF23

No disorders were found for TCF23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCF23 Gene

Publications for TCF23 Gene

  1. Genomic organization and chromosomal mapping of the basic helix-loop-helix factor OUT (Tcf23/TCF23). (PMID: 11701948) Tachibana M … Yokota Y (Cytogenetics and cell genetics 2001) 2 3 22 58
  2. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PMID: 14516699) McLellan AS … Kealey T (Mechanisms of development 2002) 3 4 58
  3. OUT, a novel basic helix-loop-helix transcription factor with an Id-like inhibitory activity. (PMID: 10652346) Narumi O … Yokota Y (The Journal of biological chemistry 2000) 2 3 58
  4. A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells. (PMID: 24571987) Kommagani R … Lydon JP (Biology of reproduction 2014) 3 58
  5. Identification of transcription factors at the site of implantation in the later stages of murine pregnancy. (PMID: 16514199) Zhao B … Bethin KE (Reproduction (Cambridge, England) 2006) 22 58

Products for TCF23 Gene

Sources for TCF23 Gene

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