Aliases for TCF21 Gene
External Ids for TCF21 Gene
Previous GeneCards Identifiers for TCF21 Gene
TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TCF21 Gene
TCF21 (Transcription Factor 21) is a Protein Coding gene. Diseases associated with TCF21 include Cardiomyopathy, Dilated, 1J and Deafness, Autosomal Dominant 10. Among its related pathways are Non-Canonical Wnt Pathway and ERK Signaling. GO annotations related to this gene include protein dimerization activity and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is MSC.
UniProtKB/Swiss-Prot for TCF21 Gene
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.