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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCF21 Gene

protein-coding   GIFtS: 55
GCID: GC06P134251

Transcription Factor 21

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcription Factor 211 2     pod-12
POD12 3 5     BHLHA233
Class A Basic Helix-Loop-Helix Protein 232 3     Capsulin3
Podocyte-Expressed 12 3     Epicardin3
bHLHa232 3     Pod-13
capsulin2     TCF-213
epicardin2     

External Ids:    HGNC: 116321   Entrez Gene: 69432   Ensembl: ENSG000001185267   OMIM: 6033065   UniProtKB: O436803   

Export aliases for TCF21 gene to outside databases

Previous GC identifers: GC06P133833 GC06P134057 GC06P134190 GC06P131779


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCF21 Gene:
TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific,
and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and
glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TCF21 Gene: 
TCF21 (transcription factor 21) is a protein-coding gene. Diseases associated with TCF21 include gigantism, and cleft lip, and among its related super-pathways are Factors Promoting Cardiogenesis in Vertebrates and MAPK Signaling. GO annotations related to this gene include histone deacetylase binding and protein dimerization activity. An important paralog of this gene is TCF24.

UniProtKB/Swiss-Prot: TCF21_HUMAN, O43680
Function: Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial
differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or
more subsets of epicardial cell types

Gene Wiki entry for TCF21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCF21 gene promoter:
         MyoD   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCF21 promoter sequence
   Search SABiosciences Chromatin IP Primers for TCF21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23-q24   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23-q24

TCF21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCF21 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P134251:  view genomic region     (about GC identifiers)

Start:
134,210,259 bp from pter      End:
134,216,691 bp from pter
Size:
6,433 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCF21_HUMAN, O43680 (See protein sequence)
Recommended Name: Transcription factor 21  
Size: 179 amino acids; 19715 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3 and
binds the E box (5'-CANNTG-3')
Subcellular location: Nucleus
Secondary accessions: E1P581 O43545 Q6ICV0 Q9BZ14

Explore the universe of human proteins at neXtProt for TCF21: NX_O43680

Explore proteomics data for TCF21 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43680

  • TCF21 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCF21 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003197.2  NP_938206.1  

    ENSEMBL proteins: 
     ENSP00000356857   ENSP00000237316  

    Human Recombinant Protein Products for TCF21: 
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    Novus Biologicals TCF21 Proteins
    Novus Biologicals TCF21 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TCF21 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12493738

    TCF21 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for TCF21


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry O43680

    ProtoNet protein and cluster: O43680

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: TCF21_HUMAN, O43680
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    TCF21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCF21_HUMAN, O43680
    Function: Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial
    differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or
    more subsets of epicardial cell types

         Genatlas biochemistry entry for TCF21:
    transcription factor 21,murine Pod-1 homolog,mesoderm specific,expressed in mesenchymal and glomerular epithelial
    cells in the developing kidney

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS--
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA12493738
    GO:0005515protein binding ----
    GO:0042826histone deacetylase binding IEA--
    GO:0043425bHLH transcription factor binding IPI12493738
         
    TCF21 for ontologies           About GeneDecksing


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Tcf21):
     cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  muscle 
     normal  renal/urinary system  reproductive system  respiratory system  tumorigenesis 

    TCF21 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tcf21tm1Eno for TCF21

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TCF21 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TCF21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCF21 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TCF21 

    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate TCF21 (see all 22):
    hsa-miR-142-5p hsa-miR-3942-5p hsa-miR-134 hsa-miR-25 hsa-let-7a-2* hsa-miR-138-2* hsa-miR-340 hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidTCF21 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF21


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TCF21 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency0.50
    Factors Promoting Cardiogenesis in Vertebrates0.50
    2Rho Family GTPases
    MAPK Signaling0.58
    ILK Signaling0.49
    3TGF-Beta Pathway
    JNK Pathway0.51
    4PAK Pathway
    Epithelial Adherens Junctions0.36
    5WNT Signaling
    WNT Signaling

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCF21 (see all 7)
        MAPK Signaling
    ILK Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Human Embryonic Stem Cell Pluripotency
    JNK Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCF21

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/12 Interacting proteins for TCF21 (O436802, 3 ENSP000002373164) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLP1P516932, 3MINT-63161 I2D: score=5 
    LMO4P619682, 3MINT-60891 I2D: score=3 
    TCF3P159233, ENSP000002629654I2D: score=4 STRING: ENSP00000262965
    APEX1P276953, ENSP000002167144I2D: score=1 STRING: ENSP00000216714
    GTF3C5Q9Y5Q83, ENSP000003611804I2D: score=1 STRING: ENSP00000361180
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA12493738
    GO:0001657ureteric bud development ISS--
    GO:0001658branching involved in ureteric bud morphogenesis ISS--
    GO:0001763morphogenesis of a branching structure ISS--
    GO:0001822kidney development ISS--

    TCF21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCF21

    Search CenterWatch for drugs/clinical trials and news about TCF21

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCF21 gene (2 alternative transcripts): 
    NM_003206.3  NM_198392.2  

    Unigene Cluster for TCF21:

    Transcription factor 21
    Hs.78061  [show with all ESTs]
    Unigene Representative Sequence: NM_198392
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367882(uc003qei.4 uc003qej.2) ENST00000237316
    miRNA
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    hsa-miR-142-5p hsa-miR-3942-5p hsa-miR-134 hsa-miR-25 hsa-let-7a-2* hsa-miR-138-2* hsa-miR-340 hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidTCF21 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCF21

    Additional mRNA sequence: 

    AF035718.1 AF047419.1 AK091844.1 AK093019.1 BC025697.1 BT019660.1 CR450293.1 

    6 DOTS entries:

    DT.100767023  DT.40286161  DT.412321  DT.415294  DT.100021579  DT.100763618 

    24/124 AceView cDNA sequences (see all 124):

    CF125244 BF433149 AL550251 AL552380 AA586575 CF126467 CR594669 BU677833 
    BU688835 CR606057 CF126927 AI262045 CR450293 BI770998 BM923344 BQ016290 
    CF128484 CR616308 BQ072411 BU581564 AA358224 BQ021615 CF127519 CF127896 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCF21 expression in normal human tissues (normalized intensities)      TCF21 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAGTGCTGA
    TCF21 Expression
    About this image


    TCF21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 12 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 6 entries
             Vascular Smooth Muscle Cells Coronary Capillary Plexus
             Human Tracheal Smooth Muscle Cells (HTSMC)   
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Epicardial Progenitors Cells Epicardium
             Human Cardiac Myocytes-adult (HCM-a)   
     
     Adipose (Muscoskeletal System)    fully expand to see all 5 entries
             Mesenchymal Stem Cells Subcutaneous White Adipose
             Visceral White Adipose
             Human Preadipocyte-visceral (HPA-v)   
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Distal Mesodermal Progenitor Cells Lung Mesoderm
             Human Tracheal Smooth Muscle Cells (HTSMC)   

    See TCF21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCF21

    SOURCE GeneReport for Unigene cluster: Hs.78061
        SABiosciences Expression via Pathway-Focused PCR Array including TCF21: 
              Lung Cancer in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TCF21 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcf211 , 5 transcription factor 211, 5 90.69(n)1
    96.09(a)1
      10 (10.33 cM)5
    214121  NM_011545.11  NP_035675.11 
     228172795 
    chicken
    (Gallus gallus)
    Aves TCF211 transcription factor 21 81.19(n)
    91.62(a)
      421697  XM_419734.2  XP_419734.1 
    lizard
    (Anolis carolinensis)
    Reptilia TCF216
    Uncharacterized protein
    65(a)
    1 ↔ 1
    GL343200.1(3768471-3774524)
    zebrafish
    (Danio rerio)
    Actinopterygii tcf211 transcription factor 21 70.48(n)
    77.14(a)
      558148  NM_001037681.1  NP_001032770.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta HLH54F6
    HLH54F
    20(a)
    1 → many
    2R(13644922-13648022)
    worm
    (Caenorhabditis elegans)
    Secernentea hlh-106
    Protein HLH-10
    19(a)
    1 → many
    V(9280702-9282154)


    ENSEMBL Gene Tree for TCF21 (if available)
    TreeFam Gene Tree for TCF21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCF21 gene
    TCF242  TCF232  MSC2  
    4 SIMAP similar genes for TCF21 using alignment to 1 protein entry:     TCF21_HUMAN:
    MSC    HAND2    TCF15    TCF24

    TCF21 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/215 SNPs in TCF21 are shown (see all 215)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs721287791,2
    C--134208422(+) TAGCT-/ACAC  
            
    ACACA
    2 -- us2k10--------
    rs1907958261,2
    --134209406(+) GCTTAA/CTGTAT 2 -- us2k10--------
    rs563897011,2
    C--134209517(+) ACACA-/CAC   
       ACACA
    CACAC
    2 -- us2k11Minor allele frequency- CACACACA:0.00NA 2
    rs609659281,2
    C--134209521(+) ACACA-/CACA/CA
    CACACACACA
    TTTCA
    2 -- us2k11NA 2
    rs1453785241,2
    C--134209618(+) AGAAAA/CGGGAG 2 -- us2k10--------
    rs1413461481,2
    --134209805(+) CTGCTA/GTGGGA 2 -- us2k10--------
    rs1439366541,2
    --134209895(+) TGCACA/CAACAA 2 -- us2k10--------
    rs65699151,2
    C,F,A,H--134209966(+) CGAAGA/GTATTA 2 -- us2k114Minor allele frequency- G:0.10NS EA NA CSA WA 1447
    rs1468724781,2
    --134210003(+) TAAAGA/GCTGAT 2 -- us2k10--------
    rs1826696581,2
    --134210065(+) TGCTAA/GCAAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TCF21 (134210259 - 134216691 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TCF21:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv34122CNV Loss18971310


    Human Gene Mutation Database (HGMD): TCF21
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603306    OMIM disorders: --

    7 diseases for TCF21:    About MalaCards
    gigantism    cleft lip    bronchiolitis    clear cell renal cell carcinoma
    lung cancer    renal cell carcinoma    melanoma


    TCF21 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TCF21
    Human Genome Epidemiology (HuGE) Navigator: TCF21 (3 documents)

    Export disorders for TCF21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCF21 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with TCF21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Epicardin: a novel basic helix-loop-helix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads. (PubMed id 9733105)1, 2, 9 Robb L.... Harvey R.P. (1998)
    2. Pod-1, a mesoderm-specific basic-helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing kidney. (PubMed id 9507058)1, 3, 9 Quaggin S.E....Igarashi P. (1998)
    3. Large-scale association analysis identifies 13 new su sceptibility loci for coronary artery disease. (PubMed id 21378990)1, 4 Schunkert H....Samani N.J. (2011)
    4. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    5. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis. (PubMed id 10572052)1, 2 Quaggin S.E....Rossant J. (1999)
    9. Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer. (PubMed id 16415157)1, 9 Smith L.T....Plass C. (2006)
    10. Down-regulation of TCF21 is associated with poor survi val in clear cell renal cell carcinoma. (PubMed id 22862160)1 Ye Y.W....Cai Z.M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6943 HGNC: 11632 AceView: TCF21 Ensembl:ENSG00000118526 euGenes: HUgn6943
    ECgene: TCF21 H-InvDB: TCF21

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCF21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCF21 gene:
    Search GeneIP for patents involving TCF21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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