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Aliases for TCF21 Gene

Aliases for TCF21 Gene

  • Transcription Factor 21 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 23 3 4
  • Podocyte-Expressed 1 3 4
  • Epicardin 3 4
  • Capsulin 3 4
  • BHLHa23 3 4
  • Pod-1 3 4
  • POD1 3 4
  • TCF-21 4

External Ids for TCF21 Gene

Previous GeneCards Identifiers for TCF21 Gene

  • GC06P134057
  • GC06P134190
  • GC06P134251
  • GC06P131779

Summaries for TCF21 Gene

Entrez Gene Summary for TCF21 Gene

  • TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCF21 Gene

TCF21 (Transcription Factor 21) is a Protein Coding gene. Among its related pathways are PAK Pathway and Human Embryonic Stem Cell Pluripotency. GO annotations related to this gene include protein dimerization activity and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is TCF24.

UniProtKB/Swiss-Prot for TCF21 Gene

  • Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.

Gene Wiki entry for TCF21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF21 Gene

Genomics for TCF21 Gene

Regulatory Elements for TCF21 Gene

Enhancers for TCF21 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TCF21 on UCSC Golden Path with GeneCards custom track

Promoters for TCF21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCF21 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCF21 Gene

Chromosome:
6
Start:
133,889,121 bp from pter
End:
133,895,553 bp from pter
Size:
6,433 bases
Orientation:
Plus strand

Genomic View for TCF21 Gene

Genes around TCF21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF21 Gene

Proteins for TCF21 Gene

  • Protein details for TCF21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43680-TCF21_HUMAN
    Recommended name:
    Transcription factor 21
    Protein Accession:
    O43680
    Secondary Accessions:
    • E1P581
    • O43545
    • Q6ICV0
    • Q9BZ14

    Protein attributes for TCF21 Gene

    Size:
    179 amino acids
    Molecular mass:
    19715 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3 and binds the E box (5-CANNTG-3).

neXtProt entry for TCF21 Gene

Proteomics data for TCF21 Gene at MOPED

Post-translational modifications for TCF21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCF21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCF21 Gene

Domains & Families for TCF21 Gene

Gene Families for TCF21 Gene

Protein Domains for TCF21 Gene

Suggested Antigen Peptide Sequences for TCF21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43680

UniProtKB/Swiss-Prot:

TCF21_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with TCF21: view

Function for TCF21 Gene

Molecular function for TCF21 Gene

GENATLAS Biochemistry:
transcription factor 21,murine Pod-1 homolog,mesoderm specific,expressed in mesenchymal and glomerular epithelial cells in the developing kidney
UniProtKB/Swiss-Prot Function:
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.

Gene Ontology (GO) - Molecular Function for TCF21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISS --
GO:0050681 androgen receptor binding ISS --
GO:0070888 E-box binding ISS --
genes like me logo Genes that share ontologies with TCF21: view
genes like me logo Genes that share phenotypes with TCF21: view

Animal Models for TCF21 Gene

MGI Knock Outs for TCF21:

Animal Model Products

Targeted motifs for TCF21 Gene
HOMER Transcription Factor Regulatory Elements motif TCF21
  • Consensus sequence: NAACAGCTGG Submotif: canonical Cell Type: ArterySmoothMuscle GEO ID: GSE61369

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for TCF21 Gene

Localization for TCF21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF21 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCF21 Gene COMPARTMENTS Subcellular localization image for TCF21 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for TCF21 Gene

Pathways & Interactions for TCF21 Gene

genes like me logo Genes that share pathways with TCF21: view

Gene Ontology (GO) - Biological Process for TCF21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12493738
GO:0001657 ureteric bud development ISS --
GO:0001763 morphogenesis of a branching structure ISS --
GO:0001822 kidney development ISS --
GO:0001944 vasculature development ISS --
genes like me logo Genes that share ontologies with TCF21: view

No data available for SIGNOR curated interactions for TCF21 Gene

Drugs & Compounds for TCF21 Gene

No Compound Related Data Available

Transcripts for TCF21 Gene

mRNA/cDNA for TCF21 Gene

Unigene Clusters for TCF21 Gene

Transcription factor 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCF21 Gene

No ASD Table

Relevant External Links for TCF21 Gene

GeneLoc Exon Structure for
TCF21
ECgene alternative splicing isoforms for
TCF21

Expression for TCF21 Gene

mRNA expression in normal human tissues for TCF21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCF21 Gene

This gene is overexpressed in Lung (x7.6), Ovary (x6.3), Spleen (x4.7), and Kidney - Cortex (x4.1).

SOURCE GeneReport for Unigene cluster for TCF21 Gene Hs.78061

genes like me logo Genes that share expression patterns with TCF21: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TCF21 Gene

Orthologs for TCF21 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TCF21 35
  • 94.04 (n)
  • 98.88 (a)
TCF21 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCF21 35
  • 94.79 (n)
  • 98.32 (a)
TCF21 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcf21 35
  • 90.69 (n)
  • 96.09 (a)
Tcf21 16
Tcf21 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TCF21 35
  • 99.81 (n)
  • 100 (a)
TCF21 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcf21 35
  • 90.88 (n)
  • 97.21 (a)
oppossum
(Monodelphis domestica)
Mammalia TCF21 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCF21 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCF21 35
  • 81.19 (n)
  • 91.62 (a)
TCF21 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCF21 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcf21 35
  • 75.79 (n)
  • 87.71 (a)
zebrafish
(Danio rerio)
Actinopterygii tcf21 35
  • 71.84 (n)
  • 79.31 (a)
tcf21 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta HLH54F 36
  • 20 (a)
OneToMany
Species with no ortholog for TCF21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCF21 Gene

ENSEMBL:
Gene Tree for TCF21 (if available)
TreeFam:
Gene Tree for TCF21 (if available)

Paralogs for TCF21 Gene

Paralogs for TCF21 Gene

(4) SIMAP similar genes for TCF21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCF21: view

Variants for TCF21 Gene

Sequence variations from dbSNP and Humsavar for TCF21 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs5880198 -- 133,893,139(+) TTTTT(-/T)CTCGG intron-variant
rs6569916 -- 133,892,641(+) GTGTG(A/G)GCATA intron-variant, downstream-variant-500B
rs6569917 -- 133,893,695(+) ATTCC(A/G)GGCAG utr-variant-3-prime
rs9493755 -- 133,894,728(+) ATAGG(G/T)GGTGA utr-variant-3-prime
rs6932322 -- 133,894,019(+) GCTCA(A/G)ATGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TCF21 Gene

Variant ID Type Subtype PubMed ID
esv34122 CNV Loss 18971310

Variation tolerance for TCF21 Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCF21 Gene

HapMap Linkage Disequilibrium report
TCF21
Human Gene Mutation Database (HGMD)
TCF21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF21 Gene

Disorders for TCF21 Gene

Relevant External Links for TCF21

Genetic Association Database (GAD)
TCF21
Human Genome Epidemiology (HuGE) Navigator
TCF21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCF21

No disorders were found for TCF21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCF21 Gene

Publications for TCF21 Gene

  1. Epicardin: a novel basic helix-loop-helix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads. (PMID: 9733105) Robb L. … Harvey R.P. (Dev. Dyn. 1998) 3 4 23 67
  2. Pod-1, a mesoderm-specific basic-helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing kidney. (PMID: 9507058) Quaggin S.E. … Igarashi P. (Mech. Dev. 1998) 2 3 23
  3. Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer. (PMID: 16415157) Smith L.T. … Plass C. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 23
  4. Protein expression and promoter methylation of the candidate biomarker TCF21 in gastric cancer. (PMID: 25156819) Yang Z. … Dai D.Q. (J. Cancer Res. Clin. Oncol. 2015) 3
  5. Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. (PMID: 26020271) Sazonova O. … Quertermous T. (PLoS Genet. 2015) 3

Products for TCF21 Gene

Sources for TCF21 Gene

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