Aliases for TCF21 Gene
External Ids for TCF21 Gene
Previous GeneCards Identifiers for TCF21 Gene
TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TCF21 Gene
TCF21 (Transcription Factor 21) is a Protein Coding gene. Diseases associated with TCF21 include clear cell renal cell carcinoma and renal cell carcinoma. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include protein dimerization activity and histone deacetylase binding. An important paralog of this gene is TCF24.
UniProtKB/Swiss-Prot for TCF21 Gene
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types