Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TCF21 Gene

protein-coding GIFtS: 55
GCID: GC06P134251

transcription factor 21

Explore 6 diseases affiliated with
TCF21 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transcription Factor 21¹ ²		Pod-1³
POD1¹ ² ³ ⁵		BHLHA23³
BHLHa23¹		Capsulin³
Class A Basic Helix-Loop-Helix Protein 23² ³		Epicardin³
Podocyte-Expressed 1² ³		Pod-1³
Capsulin³		TCF-21³
Epicardin³

External Ids:	HGNC: 11632¹	Entrez Gene: 6943²	Ensembl: ENSG00000118526⁷	OMIM: 603306⁵	UniProtKB: O43680³

Export aliases for TCF21 gene to outside databases

Previous GC identifers: GC06P133833 GC06P134057 GC06P134190 GC06P131779

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCF21:

TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and

expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular

epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TCF21_HUMAN, O43680

Function: Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial

differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more

subsets of epicardial cell types

Gene Wiki entry for TCF21

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TCF21 gene promoter:
MyoD NF-kappaB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TCF21 promoter sequence

Search SABiosciences Chromatin IP Primers for TCF21

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF21

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23-q24 Ensembl cytogenetic band: 6q23.2 HGNC cytogenetic band: 6q23-q24

TCF21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCF21 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P134251: view genomic region (about GC identifiers)

Start:	134,210,259 bp from pter	End:	134,216,691 bp from pter
Size:	6,433 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TCF21_HUMAN, O43680 (See protein sequence)

Recommended Name: Transcription factor 21

Size: 179 amino acids; 19715 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3 and binds

the E box (5'-CANNTG-3')

Subcellular location: Nucleus

Secondary accessions: E1P581 O43545 Q6ICV0 Q9BZ14

Explore the universe of human proteins at neXtProt for TCF21: NX_O43680

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43680

TCF21 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_003197.2 NP_938206.1

ENSEMBL proteins:

ENSP00000356857 ENSP00000237316

Human Recombinant Protein Products for TCF21:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: TCF21 OriGene Protein Over-expression Lysate (see all 3): TCF21 OriGene Custom Protein Services for TCF21
	GenScript Custom Purified and Recombinant Proteins Services for TCF21
	Novus Biologicals TCF21 Proteins Novus Biologicals TCF21 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TCF21

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	12493738

TCF21 for ontologies About GeneDecksing

TCF21 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: TCF21 OriGene Custom Antibody Services for TCF21
	GenScript Custom Superior Antibodies Services for TCF21
	Novus Biologicals TCF21 Antibodies
	Abcam antibodies for TCF21
	Uscn Antibodies for TCF21
	ThermoFisher Antibodies for TCF21

Assay Products for TCF21:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TCF21
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TCF21

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TCF21 for domains About GeneDecksing

1 InterPro domain/family:

IPR011598 HLH_dom

Graphical View of Domain Structure for InterPro Entry O43680

ProtoNet protein and cluster: O43680

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: TCF21_HUMAN, O43680

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TCF21_HUMAN, O43680

Function: Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial

differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more

subsets of epicardial cell types

Genatlas biochemistry entry for TCF21:

transcription factor 21,murine Pod-1 homolog,mesoderm specific,expressed in mesenchymal and glomerular epithelial cells

in the developing kidney

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	ISS	--
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	IDA	12493738
GO:0005515	protein binding	--	--
GO:0042826	histone deacetylase binding	IEA	--
GO:0043425	bHLH transcription factor binding	IPI	12493738

TCF21 for ontologies About GeneDecksing

Phenotypes:
15 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Tcf21):

cardiovascular system	craniofacial	digestive/alimentary	endocrine/exocrine gland	hematopoietic system
homeostasis/metabolism	immune system	integument	mortality/aging	muscle
normal	renal/urinary system	reproductive system	respiratory system	tumorigenesis

TCF21 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Tcf21^tm1Eno for TCF21

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TCF21

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TCF21 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCF21
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate TCF21 (see all 22):
		hsa-miR-142-5p hsa-miR-3942-5p hsa-miR-134 hsa-miR-25 hsa-let-7a-2* hsa-miR-138-2* hsa-miR-340 hsa-miR-29b-1*

		SwitchGear 3'UTR luciferase reporter plasmid: TCF21 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCF21 (see all 7) OriGene shRNA RFP: TCF21 OriGene siRNA: TCF21
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCF21
		Sirion Biotech Custom design and validation of potent shRNA sequences against TCF21

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TCF21
			Sirion Biotech Customized adenovirus for overexpression of TCF21 Sirion Biotech Customized adenovirus for potent knockdown of TCF21

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCF21 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCF21 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TCF21 (NM_198392)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCF21
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF21

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TCF21
		Search LifeMap BioReagents cell lines for TCF21
		Sirion Biotech Customized stable knockdown cell line services for TCF21 Sirion Biotech Customized inducible knockdown cell line services for TCF21 Sirion Biotech Customized stable overexpressing cell line services for TCF21 Sirion Biotech Customized inducible overexpressing cell line services for TCF21

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF21

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Human Embryonic Stem Cell Pluripotency

Human Embryonic Stem Cell Pluripotency

1.00

Factors Promoting Cardiogenesis in Vertebrates

0.50

Rho Family GTPases

MAPK Signaling

0.51

ILK Signaling

0.45

WNT Signaling

WNT Signaling

1.00

TGF-Beta Pathway

JNK Pathway

0.50

PAK Pathway

Epithelial Adherens Junctions

0.36

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCF21 (see all 7)

	MAPK Signaling
	ILK Signaling
	Factors Promoting Cardiogenesis in Vertebrates
	Human Embryonic Stem Cell Pluripotency
	JNK Pathway

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TCF21

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/12 Interacting proteins for TCF21 (O43680^{2, 3} ENSP00000237316⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APLP1	P51693²^,³	MINT-63161 I2D: score=5
LMO4	P61968²^,³	MINT-60891 I2D: score=3
TCF3	P15923³, ENSP00000262965⁴	I2D: score=4 STRING: ENSP00000262965
APEX1	P27695³, ENSP00000216714⁴	I2D: score=1 STRING: ENSP00000216714
GTF3C5	Q9Y5Q8³, ENSP00000361180⁴	I2D: score=1 STRING: ENSP00000361180

About this table

Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	12493738
GO:0001657	ureteric bud development	ISS	--
GO:0001658	branching involved in ureteric bud morphogenesis	ISS	--
GO:0001763	morphogenesis of a branching structure	ISS	--
GO:0001822	kidney development	ISS	--

TCF21 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TCF21
Search CenterWatch for drugs/clinical trials and news about TCF21

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TCF21 gene (2 alternative transcripts):

NM_003206.3 NM_198392.2

Unigene Cluster for TCF21:

Transcription factor 21

Hs.78061 [show with all ESTs]

Unigene Representative Sequence: NM_198392

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367882(uc003qei.4 uc003qej.2) ENST00000237316

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TCF21 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCF21
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate TCF21 (see all 22):
		hsa-miR-142-5p hsa-miR-3942-5p hsa-miR-134 hsa-miR-25 hsa-let-7a-2* hsa-miR-138-2* hsa-miR-340 hsa-miR-29b-1*

		SwitchGear 3'UTR luciferase reporter plasmid: TCF21 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCF21 (see all 7) OriGene shRNA RFP: TCF21 OriGene siRNA: TCF21
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCF21
		Sirion Biotech Custom design and validation of potent shRNA sequences against TCF21

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCF21 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCF21 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TCF21 (NM_198392)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCF21
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF21

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCF21 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TCF21
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCF21
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCF21

Additional cDNA sequence:

AF035718.1 AF047419.1 AK091844.1 AK093019.1 BC025697.1 BT019660.1 CR450293.1

6 DOTS entries:

DT.100767023 DT.40286161 DT.412321 DT.415294 DT.100021579 DT.100763618

24/124 AceView cDNA sequences (see all 124):

AA358224 AL550251 BI770998 BF433149 CF126927 AI628260 BQ021615 BX107489

CF128914 AL552380 AA586575 CF126467 BU677833 BF221953 BM923344 CR606057

CR594669 AF035718 BQ072411 BU581564 BQ019293 CR450293 CF127519 CR616308

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TCF21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGAGTGCTGA

About this image

TCF21 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/23 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 23)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Branchial Arch 1

Paraxial Mesoderm Cells

Selective marker (cell-identifying gene)

Bone, Skeletal Muscle

Head Mesenchyme

Branchial Arch 2

Paraxial Mesoderm Cells

Skeletal Muscle

Head Mesenchyme

Paraxial Mesoderm Cells

Bone, Skeletal Muscle

Lateral Plate Mesoderm

Proepicardium

Proepicardial Progenitor cells

Epicardium

Skeletal Muscle

Hyoid Arch Muscles

Muscle Progenitor Cells

Skeletal Muscle

Mandibular Arch Muscles

Muscle Progenitor Cells

Skeletal Muscle

Mandibular Arch Muscles

Muscle Satellite Cells

Skeletal Muscle

Head Mesenchyme

Prechordal Mesenchyme

Prechordal Mesoderm Cells

Skeletal Muscle

Adipose

Body Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Visceral White Adipose

Visceral White Preadipocytes

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Posterior foregut-like cells (A scalable, suspensi...)

Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)

Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorti...)

Alveolar type II cells (Derivation of mature...)

Lung

See TCF21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCF21

SOURCE GeneReport for Unigene cluster: Hs.78061

SABiosciences Expression via Pathway-Focused PCR Array including TCF21:

Lung Cancer in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCF21 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TCF21
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCF21
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCF21

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF21

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TCF21 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TCF21¹	transcription factor 21	81.19(n) 91.62(a)		421697 XM_419734.2 XP_419734.1
lizard (Anolis carolinensis)	Reptilia	TCF21⁶	--	61(a)	1 ↔ 1	GL343200.1(3768471-3774457)
zebrafish (Danio rerio)	Actinopterygii	tcf21¹	transcription factor 21	70.48(n) 77.14(a)		558148 NM_001037681.1 NP_001032770.1
fruit fly (Drosophila melanogaster)	Insecta	HLH54F⁶	HLH54F	19(a)	1 → many	2R(13644922-13648022)

ENSEMBL Gene Tree for TCF21 (if available)
TreeFam Gene Tree for TCF21 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TCF21 gene

TCF24² NHLH1² TWIST1² TAL1² TWIST2² HAND2² TCF23² LYL1²

NHLH2² TAL2² TCF15² SCXB² HAND1² MSC² SCXA²

4 SIMAP similar genes for TCF21 using alignment to 1 protein entry: TCF21_HUMAN:

MSC HAND2 TCF15 TCF24

TCF21 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6569915^1,2	C,F,A,H	--	131778237(+)	`CGAAGA/GTATTA`	2	--	us2k¹		14		NS EA NA CSA WA	1447
rs75232761^1,2		--	131778766(+)	`ACAAAA/GACAGC`	2	--	us2k¹		0	--	--	--	--
rs77913204^1,2	C,F	--	131779029(+)	`GTACAC/TGTAGG`	2	--	us2k¹		1		NA	120
rs73774136^1,2	C	--	131779268(+)	`AAGGCC/ACAGAA`	2	--	us2k¹		2		WA	120
rs79935065^1,2		--	131779624(+)	`CTACGG/ACCACG`	2	--	ut5¹		1		WA	118
rs12209636^1,2	C,F,H	--	131779908(+)	`CCTCAG/ACGATG`	4	/N /S	mis¹ ese³		10		NS EA NA	1300
rs62424130^1,2	C	--	131780810(+)	`ACAAGC/TATATT`	2	--	int¹		2		NA	122
rs77899663^1,2	C,F	--	131781512(+)	`AGAAAC/TTTAAA`	2	--	int¹		1		WA	118
rs112597321^1,2		--	131781613(+)	`TAGTAC/TAGCAT`	2	--	int¹		1		CSA	2
rs17063105^1,2	C,F,H	--	131781795(+)	`GCCCCG/TAACTC`	2	--	int¹		13		NA NS EA CSA WA	1447

HapMap Linkage Disequilibrium report for TCF21 (134210259 - 134216691 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TCF21
1 CNV: 47958
Human Gene Mutation Database (HGMD): TCF21

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCF21

DNA2.0 Custom Variant and Variant Library Synthesis for TCF21

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TCF21 for disorders           About GeneDecksing

OMIM gene information: 603306    OMIM disorders: --

6 diseases for TCF21:    About MalaCards

cleft lip/palate cleft lip gigantism bronchiolitis

melanoma lung cancer

Human Genome Epidemiology (HuGE) Navigator: TCF21 (3 documents)

Export disorders for TCF21 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TCF21 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with TCF21)

Utopia: connect your pdf to the dynamic
world of online information

Epicardin: a novel basic helix-loop-helix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads. (PubMed id 9733105)^{1, 2, 9} Robb L.... Harvey R.P. (1998)
Pod-1, a mesoderm-specific basic-helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing kidney. (PubMed id 9507058)^{1, 3, 9} Quaggin S.E....Igarashi P. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis. (PubMed id 10572052)^{1, 2} Quaggin S.E....Rossant J. (1999)
Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer. (PubMed id 16415157)^{1, 9} Smith L.T....Plass C. (2006)
Down-regulation of TCF21 is associated with poor survi val in clear cell renal cell carcinoma. (PubMed id 22862160)¹ Ye Y.W....Cai Z.M. (2012)
Genome-wide association study in Han Chinese identifie s four new susceptibility loci for coronary artery disease. (PubMed id 22751097)¹ Lu X....Gu D. (2012)
Epigenetic deregulation of TCF21 inhibits metastasis suppressor KISS1 in metastatic melanoma. (PubMed id 21771727)¹ Arab K....Plass C. (2011)
Large-scale association analysis identifies 13 new su sceptibility loci for coronary artery disease. (PubMed id 21378990)¹ Schunkert H....Samani N.J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6943	HGNC: 11632	AceView: TCF21	Ensembl:ENSG00000118526	euGenes: HUgn6943
ECgene: TCF21	H-InvDB: TCF21

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TCF21	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TCF21 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TCF21 gene:
Search GeneIP for patents involving TCF21

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for TCF21		OriGene shRNA RFP for TCF21
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCF21		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCF21
	OriGene Protein Over-expression Lysate for TCF21		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TCF21		OriGene 3'-UTR Clone for TCF21
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCF21		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCF21
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for TCF21		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TCF21		OriGene Custom Protein Services for TCF21
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCF21
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCF21
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF21
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCF21
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCF21
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCF21

	GenScript Custom Purified and Recombinant Proteins Services for TCF21		GenScript cDNA clones with any tag delivered in your preferred vector for TCF21
	GenScript Custom Assay Services for TCF21		GenScript Custom Superior Antibodies Services for TCF21
	GenScript Custom overexpressing Cell Line Services for TCF21		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TCF21 promoter
	Search Chromatin IP Primers for TCF21
	RT² qPCR Primer Assay in human, mouse, rat TCF21
	Search GNC Networks for TCF21
	SABiosciences PCR Arrays including human, mouse, rat TCF21

Search Tocris compounds for TCF21

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TCF21 antibodies
	TCF21 proteins
	TCF21 lysates

	Antibodies for TCF21
	See all of Abcam's Antibodies, Kits and Proteins for TCF21
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TCF21 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TCF21

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF21

	SwitchGear 3'UTR luciferase reporter plasmids for TCF21
	SwitchGear Promoter luciferase reporter plasmids for TCF21

ThermoFisher Antibodies for TCF21

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF21

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TCF21

Sirion Biotech Customized:

	stable knockdown cell line services for TCF21
	inducible knockdown cell line services for TCF21
	design and validation of potent shRNA sequences against TCF21
	adenovirus for potent knockdown of TCF21
	adenovirus for overexpression of TCF21
	stable overexpressing cell line services for TCF21
	inducible overexpressing cell line services for TCF21

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TCF21 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

TCF21 Gene

transcription factor 21

Aliases
for TCF21 gene

Summaries
for TCF21 gene

Genomic Views
for TCF21 gene

Proteins
for TCF21 gene

Protein Domains /
Families
for TCF21 gene

Function
for TCF21 gene

Pathways & Interactions
for TCF21 gene

Drugs & Compounds
for TCF21 gene

Transcripts
for TCF21 gene

Expression
for TCF21 gene

Orthologs
for TCF21 gene

Paralogs
for TCF21 gene

Genomic Variants
for TCF21 gene

Disorders / Diseases
for TCF21 gene

Publications
for TCF21 gene

External Searches for TCF21 gene

Genome Databases showing TCF21 gene

Other Databases showing TCF21 gene

Specialized Databases showing TCF21 gene

Intellectual Property
for TCF21 gene

Products
for TCF21 gene

View Random Gene

Advanced Search

Export list of displayed genes

TCF21 Gene

transcription factor 21

Aliasesfor TCF21 gene

Summariesfor TCF21 gene

Genomic Viewsfor TCF21 gene

Proteinsfor TCF21 gene

Protein Domains /Familiesfor TCF21 gene

Functionfor TCF21 gene

Pathways & Interactionsfor TCF21 gene

Drugs & Compoundsfor TCF21 gene

Transcriptsfor TCF21 gene

Expression for TCF21 gene

Orthologsfor TCF21 gene

Paralogsfor TCF21 gene

Genomic Variantsfor TCF21 gene

Disorders / Diseasesfor TCF21 gene

Publicationsfor TCF21 gene

External Searches for TCF21 gene

Genome Databases showing TCF21 gene

Other Databases showing TCF21 gene

Specialized Databases showing TCF21 gene

Intellectual Propertyfor TCF21 gene

Productsfor TCF21 gene

View Random Gene

Aliases
for TCF21 gene

Summaries
for TCF21 gene

Genomic Views
for TCF21 gene

Proteins
for TCF21 gene

Protein Domains /
Families
for TCF21 gene

Function
for TCF21 gene

Pathways & Interactions
for TCF21 gene

Drugs & Compounds
for TCF21 gene

Transcripts
for TCF21 gene

Expression
for TCF21 gene

Orthologs
for TCF21 gene

Paralogs
for TCF21 gene

Genomic Variants
for TCF21 gene

Disorders / Diseases
for TCF21 gene

Publications
for TCF21 gene

Intellectual Property
for TCF21 gene

Products
for TCF21 gene