TCF20 Gene
protein-coding GIFtS: 49
GCID: GC22M042556
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transcription factor 20 (AR1)
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Aliases for TCF20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Transcription Factor 20 (AR1)1 2 | | SPRE-Binding Protein2 3 | | SPBP1 2 3 5 | | Stromelysin-1 Platelet-Derived Growth Factor-Responsive Element Binding Protein2 | | AR11 2 5 | | Transcription Factor 202 | | Nuclear Factor SPBP2 3 | | KIAA02923 | | Stromelysin-1 PDGF-Responsive Element-Binding Protein2 3 | | Protein AR13 | | TCF-202 3 | | |
Export aliases for TCF20 gene to outside databasesPrevious GC identifers: GC22M039158 GC22M040786 GC22M040880 GC22M025521 |
Summaries for TCF20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for TCF20: The protein encoded by this gene binds a platelet-derived growth factor-responsive element in the matrixmetalloproteinase 3 (stromelysin 1) promoter. The protein localizes to the nucleus and displays DNA-binding andtransactivation activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcriptionfactors such as JUN and SP1. Alternative splicing results in two transcript variants encoding different isoforms.(provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: TCF20_HUMAN, Q9UGU0Function: Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysinexpression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1,suggesting a function as a coactivator Gene Wiki entry for TCF20
|
Genomic Views for TCF20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TCF20 gene promoter: STAT1 STAT4 STAT1beta STAT5A STAT1alpha GATA-2 c-Ets-1 Nkx6-1 STAT2 STAT3 Other transcription factors
Search SABiosciences Chromatin IP Primers for TCF20
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF20 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.3|22q13.3 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.3TCF20 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M042556: view genomic region
(about GC identifiers)
Start:
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42,556,019 bp from pter |
End:
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42,739,622 bp from pter |
Size:
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183,604 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr22-,PATCHES 42,549,912-42,605,343 |
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Proteins for TCF20 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TCF20_HUMAN, Q9UGU0 (See
protein sequence)Recommended Name: Transcription factor 20 Size: 1960 amino acids; 211771 Da
Subunit: Homodimer (Probable). Interacts with RNF4 and JUN (By similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=AAC36392.1; Type=Frameshift; Positions=1932; Sequence=CAB42440.1; Type=Erroneous initiation;
Secondary accessions: A9JX12 O14528 Q13078 Q4V353 Q9H4M0Alternative splicing: 2 isoforms: Q9UGU0-1 Q9UGU0-2 Explore the universe of human proteins at neXtProt for TCF20: NX_Q9UGU0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UGU0 TCF20 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (2 alternative transcripts):
NP_005641.1 NP_852469.1 ENSEMBL proteins: ENSP00000352463 ENSP00000335561 ENSP00000385531 ENSP00000458948 Human Recombinant Protein Products for TCF20:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
TCF20 for ontologies About GeneDecksing
TCF20 Antibody Products: Assay Products for TCF20: |
Protein
Domains / Families for TCF20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCF20 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UGU0ProtoNet protein and cluster: Q9UGU0 UniProtKB/Swiss-Prot: TCF20_HUMAN, Q9UGU0Domain: The atypical PHD domain functions as a negative modulator of cofactor binding (By similarity)Similarity: Contains 1 A.T hook DNA-binding domainSimilarity: Contains 1 PHD-type zinc finger |
Function for TCF20 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: TCF20_HUMAN, Q9UGU0Function: Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysinexpression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1,suggesting a function as a coactivator Genatlas biochemistry entry for TCF20:transcription factor 20 (TCF20),highly homolog to Spbp,a murine activator of expression of stromelysin 1
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TCF20 for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCF20 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCF20 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TCF20 (NM_005650) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCF20 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF20  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF20 |
|
Pathways & Interactions for TCF20 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Human Embryonic Stem Cell Pluripotency | | | 2 | Rho Family GTPases | | | 3 | WNT Signaling | | | 4 | Matrix Metalloproteinases | | | 5 | TGF-Beta Pathway | |
5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCF20 (see all 7) 1 BioSystems Pathway for TCF20 
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCF20
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
 5/10 Interacting proteins for TCF20 (Q9UGU03 ENSP000003524634) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | 10995766 |
TCF20 for ontologies About GeneDecksing
|
Drugs & Compounds for TCF20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for TCF20 Search CenterWatch for drugs/clinical trials and news about TCF20 
|
Transcripts for TCF20 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TCF20 gene (2 alternative transcripts): NM_005650.1 NM_181492.1 Unigene Cluster for TCF20: Transcription factor 20 (AR1) Hs.475018 [show with all ESTs]Unigene Representative Sequence: NM_0056504 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000359486(uc003bcj.1 uc003bck.1) ENST00000335626 ENST00000404876 ENST00000515426
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCF20 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCF20 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TCF20 (NM_005650) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCF20 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF20  |
Additional cDNA sequence: AB006630.1 BC013180.1 U19345.1 8 DOTS entries: DT.100755476 DT.452850 DT.97840617 DT.120670184 DT.40311879 DT.92442059 DT.95078444 DT.95303186 24/61 AceView cDNA sequences (see all 61): AI655626 AA743744 BQ020783 BM551985 BM727183 AI276226 AI468794 AI811502 AI696204 BE465181 AI768149 AI741058 AI269501 AI671963 BF001739 AA610376 BC013180 AI421827 AI631629 AW662309 AI023851 AW592385 BF593731 BE673038 GeneLoc Exon Structure
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Expression for TCF20 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCF20 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
 About this image See TCF20 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TCF20
SOURCE GeneReport for Unigene cluster: Hs.475018
UniProtKB/Swiss-Prot: TCF20_HUMAN, Q9UGU0Tissue specificity: Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed inbrain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung SABiosciences Expression via Pathway-Focused PCR Array including TCF20:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCF20 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TCF20 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCF20 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCF20 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF20 |
Orthologs for TCF20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TCF20 gene from 7/19 species (see all 19) About this table
ENSEMBL Gene Tree for TCF20 (if available) TreeFam Gene Tree for TCF20 (if available)  |
Paralogs for TCF20 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TCF20 gene
- RAI12
TCF20 for paralogs About GeneDecksing
|
Genomic Variants for TCF20 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 22 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for TCF20 (42556019 - 42739622 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TCF20: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCF20 |
|
Disorders
/ Diseases for TCF20 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCF20 for disorders About GeneDecksing
OMIM gene information: 603107
OMIM disorders: --
7 diseases for TCF20: About MalaCardspseudosarcomatous fibromatosis vertebrobasilar insufficiency gestational diabetes fibromatosis prostate cancer obesity prostatitis 1 disease from the University of Copenhagen DISEASES database for TCF20:Pseudosarcomatous fibromatosis Human Genome Epidemiology (HuGE) Navigator: TCF20 (13 documents) Export disorders for TCF20 gene to outside databases
|
Publications for TCF20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCF20 gene, integrated from 9 sources (see all 36): (articles sorted by number of sources associating them with TCF20) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators. (PubMed id 10995766)1, 2, 3, 9 Rekdal C.... Johansen T. (2000)
- Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization. (PubMed id 9730594)1, 2, 3, 9 Rajadhyaksha A.... Bina M. (1998)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PubMed id 9179496)1, 2 Ohara O....Nomura N. (1997)
- The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription. (PubMed id 17913746)1, 9 Sjottem E....Johansen T. (2007)
- SPBP is a phosphoserine-specific repressor of estrogen receptor alpha. (PubMed id 15831449)1, 9 Gburcik V....Picard D. (2005)
- Identification of two independent nucleosome-binding d omains in the transcriptional co-activator SPBP. (PubMed id 22081970)1 Darvekar S....Sjottem E. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Pax6 represses androgen receptor-mediated transactivat ion by inhibiting recruitment of the coactivator SPBP. (PubMed id 21935435)1 Elvenes J....Johansen T. (2011)
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External Searches for TCF20 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TCF20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCF20 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TCF20 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for TCF20 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TCF20 gene: Search GeneIP for patents involving TCF20
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TCF20 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for TCF20 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCF20 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCF20 | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for TCF20 | | OriGene 3'-UTR Clone for TCF20 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCF20 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCF20 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | TCF20 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF20 |
|  |  |  |  | | | Search ThermoFisher Antibodies for TCF20 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF20 |
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