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TCF20 Gene

protein-coding   GIFtS: 53
GCID: GC22M042556

Transcription Factor 20 (AR1)

  See TCF20-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Factor 20 (AR1)1 2     SPRE-Binding Protein2 3
SPBP2 3 5     AR12 5
Stromelysin-1 Platelet-Derived Growth Factor-Responsive Element Binding
Protein1 2
     Transcription Factor 202
Nuclear Factor SPBP2 3     KIAA02923
Stromelysin-1 PDGF-Responsive Element-Binding Protein2 3     Protein AR13
TCF-202 3     

External Ids:    HGNC: 116311   Entrez Gene: 69422   Ensembl: ENSG000001002077   OMIM: 6031075   UniProtKB: Q9UGU03   

Export aliases for TCF20 gene to outside databases

Previous GC identifers: GC22M039158 GC22M040786 GC22M040880 GC22M025521


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCF20 Gene:
This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in
the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator,
enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for TCF20 Gene:
TCF20 (transcription factor 20 (AR1)) is a protein-coding gene. Diseases associated with TCF20 include pseudosarcomatous fibromatosis. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is RAI1.

UniProtKB/Swiss-Prot: TCF20_HUMAN, Q9UGU0
Function: Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin
expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1,
suggesting a function as a coactivator

Gene Wiki entry for TCF20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NT_187682.1  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCF20 gene promoter:
         STAT1   STAT4   STAT1beta   STAT5A   STAT1alpha   GATA-2   c-Ets-1   Nkx6-1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCF20 promoter sequence
   Search Chromatin IP Primers for TCF20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCF20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.3|22q13.3   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.3

TCF20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCF20 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M042556:  view genomic region     (about GC identifiers)

Start:
42,556,019 bp from pter      End:
42,739,622 bp from pter
Size:
183,604 bases      Orientation:
minus strand

1 alternative location:
Chr22-,NW_003315971 65,900-121,331     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCF20_HUMAN, Q9UGU0 (See protein sequence)
Recommended Name: Transcription factor 20  
Size: 1960 amino acids; 211771 Da
Subunit: Homodimer (Probable). Interacts with RNF4 and JUN (By similarity)
Sequence caution: Sequence=AAC36392.1; Type=Frameshift; Positions=1932; Sequence=CAB42440.1; Type=Erroneous
initiation;
Secondary accessions: A9JX12 O14528 Q13078 Q4V353 Q9H4M0
Alternative splicing: 2 isoforms:  Q9UGU0-1   Q9UGU0-2   

Explore the universe of human proteins at neXtProt for TCF20: NX_Q9UGU0

Explore proteomics data for TCF20 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys844, Lys1086, Lys1267
  • Modification sites at PhosphoSitePlus

  • See TCF20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005641.1  NP_852469.1  

    ENSEMBL proteins: 
     ENSP00000352463   ENSP00000335561   ENSP00000385531   ENSP00000458948  

    TCF20 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TCF20
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TCF20

     
    Search eBioscience for Proteins for TCF20 

    TCF20 Antibody Products:

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    Search for Antibodies for TCF20 at Abcam
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    Search ThermoFisher Antibodies for TCF20
    LSBio Antibodies in human, mouse, rat for TCF20

    TCF20 Assay Products:

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    Cloud-Clone Corp. ELISAs for TCF20
    Cloud-Clone Corp. CLIAs for TCF20
    Search eBioscience for ELISAs for TCF20 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001965 Znf_PHD

    Graphical View of Domain Structure for InterPro Entry Q9UGU0

    ProtoNet protein and cluster: Q9UGU0

    UniProtKB/Swiss-Prot: TCF20_HUMAN, Q9UGU0
    Domain: The atypical PHD domain functions as a negative modulator of cofactor binding (By similarity)
    Similarity: Contains 1 A.T hook DNA-binding domain
    Similarity: Contains 1 PHD-type zinc finger


    Find genes that share domains with TCF20           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCF20_HUMAN, Q9UGU0
    Function: Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin
    expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1,
    suggesting a function as a coactivator

         Genatlas biochemistry entry for TCF20:
    transcription factor 20 (TCF20),highly homolog to Spbp,a murine activator of expression of stromelysin 1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS10995766
    GO:0003713transcription coactivator activity NAS10995766
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with TCF20           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCF20
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TCF20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCF20
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TCF20

    miRNA
    Products:
        
    miRTarBase miRNAs that target TCF20:
    hsa-mir-149-5p (MIRT045691)

    Block miRNA regulation of human, mouse, rat TCF20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TCF20 (see all 74):
    hsa-miR-579 hsa-miR-520e hsa-miR-188-5p hsa-miR-1260b hsa-miR-759 hsa-miR-520b hsa-miR-647 hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmidTCF20 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TCF20
    Predesigned siRNA for gene silencing in human, mouse, rat TCF20

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): TCF20 (NM_005650)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCF20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF20

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TCF20 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF20


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCF20_HUMAN, Q9UGU0: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10995766
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with TCF20           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TCF20 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Human Embryonic Stem Cell Pluripotency
    Factors Promoting Cardiogenesis in Vertebrates0.50
    Human Embryonic Stem Cell Pluripotency0.50
    2ERK Signaling
    MAPK Signaling0.58
    ILK Signaling0.49
    3Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    4TGF-Beta Pathway
    JNK Pathway0.51
    5PAK Pathway
    Epithelial Adherens Junctions0.36

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TCF20 (see all 7)
        MAPK Signaling
    ILK Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Human Embryonic Stem Cell Pluripotency
    JNK Pathway

    1 BioSystems Pathway for TCF20
        Matrix Metalloproteinases


        Pathway & Disease-focused RT2 Profiler PCR Array including TCF20: 
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TCF20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for TCF20 (Q9UGU03 ENSP000003524634) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054123, ENSP000003602664I2D: score=3 STRING: ENSP00000360266
    ESR1P033723, ENSP000002062494I2D: score=2 STRING: ENSP00000206249
    RNF4P783173, ENSP000003152124I2D: score=3 STRING: ENSP00000315212
    SMAD1Q157973, ENSP000003057694I2D: score=2 STRING: ENSP00000305769
    MAPK14Q165393, ENSP000002297944I2D: score=3 STRING: ENSP00000229794
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated NAS10995766

    Find genes that share ontologies with TCF20           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCF20



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TCF20 gene (2 alternative transcripts): 
    NM_005650.2  NM_181492.2  

    Unigene Cluster for TCF20:

    Transcription factor 20 (AR1)
    Hs.475018  [show with all ESTs]
    Unigene Representative Sequence: NM_005650
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359486(uc003bcj.1 uc003bck.1) ENST00000335626 ENST00000404876
    ENST00000515426
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TCF20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TCF20 (see all 74):
    hsa-miR-579 hsa-miR-520e hsa-miR-188-5p hsa-miR-1260b hsa-miR-759 hsa-miR-520b hsa-miR-647 hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmidTCF20 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TCF20
    Clone
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    OriGene ORF clones in mouse, rat for TCF20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TCF20 (NM_005650)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCF20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF20
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TCF20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TCF20
      QuantiTect SYBR Green Assays in human, mouse, rat TCF20
      QuantiFast Probe-based Assays in human, mouse, rat TCF20

    Additional mRNA sequence: 

    AB006630.1 BC013180.1 U19345.1 

    8 DOTS entries:

    DT.100755476  DT.452850  DT.97840617  DT.120670184  DT.40311879  DT.92442059  DT.95078444  DT.95303186 

    Selected AceView cDNA sequences (see all 61):

    AI655626 BQ020783 BM551985 AA743744 BC013180 AI276226 BM727183 AI468794 
    AI811502 AI421827 BE465181 AI741058 BF001739 AI269501 AI696204 AI768149 
    AA610376 AI671963 AI631629 AW592385 AW662309 AI023851 BF593731 BE222231 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCF20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TCF20 Expression
    About this image

    TCF20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCF20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.475018

    UniProtKB/Swiss-Prot: TCF20_HUMAN, Q9UGU0
    Tissue specificity: Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in
    brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung

        Pathway & Disease-focused RT2 Profiler PCR Array including TCF20: 
              Tumor Metastasis in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TCF20
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TCF20 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcf201 , 5 transcription factor 201, 5 88.68(n)1
    91.51(a)1
      15 (38.73 cM)5
    214111  NM_001114140.11  NP_001107612.11 
     828086295 
    chicken
    (Gallus gallus)
    Aves TCF201 transcription factor 20 (AR1) 75.79(n)
    77.45(a)
      417980  XM_004937687.1  XP_004937744.1 
    lizard
    (Anolis carolinensis)
    Reptilia TCF206
    transcription factor 20 (AR1)
    74(a)
    1 ↔ 1
    5(27270816-27325510)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.168602 Xenopus laevis transcribed sequence with weak similarity more 77.51(n)    BX852062.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tcf206
    transcription factor 20
    22(a)
    1 ↔ 1
    3(2023727-2032233) ENSDARG00000078348
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50986
    --
    16(a)
    1 → many
    2R(13982457-13988536)


    ENSEMBL Gene Tree for TCF20 (if available)
    TreeFam Gene Tree for TCF20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCF20 gene
    RAI12  

    Find genes that share paralogs with TCF20           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCF20 (see all 1426)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2002699701,2
    C--25526026(+) TCTTTC/TTTTTT 2 -- int10--------
    rs581971491,2
    C--25540252(+) ACCAA-/GCTAAA 2 -- int10--------
    rs589456491,2
    C--25550093(+) GTCTC-/AAA   
      AAAAAA
    AAAAA
    2 -- int10--------
    rs1472293821,2
    C--25561653(+) GGTTT-/TTTC  
            
    TTTTT
    2 -- int10--------
    rs588216461,2
    C--25561660(+) TTTTT-/C/CT/ 
    CTT
    /CTTT
    TTTAT
    4 -- int1 cds11NA 2
    rs577073041,2
    C--25562333(+) AAAAA-/A/AA  
            
    GTCTA
    2 -- int11NA 2
    rs119128651,2
    C,F,H--26471456(+) CGGCAC/TGGCGC 2 -- ds50019Minor allele frequency- T:0.14NS EA NA WA CSA 528
    rs1851270731,2
    --26471486(+) CTGGCA/GGAGTG 2 -- ds50010--------
    rs1898812951,2
    --26471496(+) GAAATA/GAGAAA 2 -- ds50010--------
    rs1839413081,2
    --26471514(+) CTTGAC/TGTAGC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for TCF20 (42556019 - 42739622 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TCF20:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3643CNV Insertion18451855
    nsv834210CNV Loss17160897
    nsv834211CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCF20
    DNA2.0 Custom Variant and Variant Library Synthesis for TCF20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603107    OMIM disorders: --

    1 disease for TCF20:    
    About MalaCards
    pseudosarcomatous fibromatosis

    1 disease from the University of Copenhagen DISEASES database for TCF20:
    Pseudosarcomatous fibromatosis

    Find genes that share disorders with TCF20           About GenesLikeMe

    Genetic Association Database (GAD): TCF20
    Human Genome Epidemiology (HuGE) Navigator: TCF20 (13 documents)

    Export disorders for TCF20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCF20 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with TCF20)
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    1. The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators. (PubMed id 10995766)1, 2, 3, 9 Rekdal C.... Johansen T. (J. Biol. Chem. 2000)
    2. Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization. (PubMed id 9730594)1, 2, 3, 9 Rajadhyaksha A.... Bina M. (Cytogenet. Cell Genet. 1998)
    3. Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight. (PubMed id 20490451)1, 4 Andersson E.A....Pedersen O. (Diabetologia 2010)
    4. Obesity and diabetes genetic variants associated with gestational weight gain. (PubMed id 20816152)1, 4 Stuebe A.M....Siega-Riz A.M. (Am. J. Obstet. Gynecol. 2010)
    5. Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. (PubMed id 20509872)1, 4 Han X....Ji L. (BMC Med. Genet. 2010)
    6. Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. (PubMed id 20564319)1, 4 Kim S.T....Sun J. (Prostate 2010)
    7. Common type 2 diabetes risk gene variants associate with gestational diabetes. (PubMed id 18984664)1, 4 Lauenborg J....Hansen T. (J. Clin. Endocrinol. Metab. 2009)
    8. Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study. (PubMed id 19720844)1, 4 Schulze M.B....Joost H.G. (Diabetes Care 2009)
    9. Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies. (PubMed id 19082521)1, 4 Ruchat S.M....PAcrusse L. (Acta Diabetol 2009)
    10. Underlying genetic models of inheritance in established type 2 diabetes associations. (PubMed id 19602701)1, 4 Salanti G....Ioannidis J.P. (Am. J. Epidemiol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6942 HGNC: 11631 AceView: TCF20.1 Ensembl:ENSG00000100207 euGenes: HUgn6942
    ECgene: TCF20 H-InvDB: TCF20

    (According to HUGE)
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    HUGE: KIAA0292

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCF20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCF20 gene:
    Search GeneIP for patents involving TCF20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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