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Aliases for TCF20 Gene

Aliases for TCF20 Gene

  • Transcription Factor 20 (AR1) 2 3
  • SPBP 3 4 6
  • Stromelysin-1 Platelet-Derived Growth Factor-Responsive Element Binding Protein 2 3
  • Stromelysin-1 PDGF-Responsive Element-Binding Protein 3 4
  • SPRE-Binding Protein 3 4
  • Nuclear Factor SPBP 3 4
  • TCF-20 3 4
  • AR1 3 6
  • Transcription Factor 20 3
  • Protein AR1 4
  • KIAA0292 4

External Ids for TCF20 Gene

Previous GeneCards Identifiers for TCF20 Gene

  • GC22M039158
  • GC22M040786
  • GC22M040880
  • GC22M042556
  • GC22M025521

Summaries for TCF20 Gene

Entrez Gene Summary for TCF20 Gene

  • This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for TCF20 Gene

TCF20 (Transcription Factor 20 (AR1)) is a Protein Coding gene. Diseases associated with TCF20 include pseudosarcomatous fibromatosis. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is RAI1.

UniProtKB/Swiss-Prot for TCF20 Gene

  • Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator

Gene Wiki entry for TCF20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF20 Gene

Genomics for TCF20 Gene

Regulatory Elements for TCF20 Gene

Genomic Location for TCF20 Gene

Start:
42,160,013 bp from pter
End:
42,343,616 bp from pter
Size:
183,604 bases
Orientation:
Minus strand

Genomic View for TCF20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCF20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF20 Gene

Proteins for TCF20 Gene

  • Protein details for TCF20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGU0-TCF20_HUMAN
    Recommended name:
    Transcription factor 20
    Protein Accession:
    Q9UGU0
    Secondary Accessions:
    • A9JX12
    • O14528
    • Q13078
    • Q4V353
    • Q9H4M0

    Protein attributes for TCF20 Gene

    Size:
    1960 amino acids
    Molecular mass:
    211771 Da
    Quaternary structure:
    • Homodimer (Probable). Interacts with RNF4 and JUN (By similarity).
    SequenceCaution:
    • Sequence=AAC36392.1; Type=Frameshift; Positions=1932; Evidence={ECO:0000305}; Sequence=CAB42440.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TCF20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCF20 Gene

Proteomics data for TCF20 Gene at MOPED

Post-translational modifications for TCF20 Gene

  • Ubiquitination at Lys844, Lys1086, and Lys1267
  • Modification sites at PhosphoSitePlus

Other Protein References for TCF20 Gene

No data available for DME Specific Peptides for TCF20 Gene

Domains for TCF20 Gene

Protein Domains for TCF20 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCF20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UGU0

UniProtKB/Swiss-Prot:

TCF20_HUMAN :
  • Q9UGU0
Domain:
  • The atypical PHD domain functions as a negative modulator of cofactor binding.
  • Contains 1 A.T hook DNA-binding domain.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with TCF20: view

No data available for Gene Families for TCF20 Gene

Function for TCF20 Gene

Molecular function for TCF20 Gene

GENATLAS Biochemistry: transcription factor 20 (TCF20),highly homolog to Spbp,a murine activator of expression of stromelysin 1
UniProtKB/Swiss-Prot Function: Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator

Gene Ontology (GO) - Molecular Function for TCF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 10995766
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0003713 transcription coactivator activity NAS 10995766
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TCF20: view

miRNA for TCF20 Gene

miRTarBase miRNAs that target TCF20

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TCF20 Gene

Localization for TCF20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF20 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCF20 Gene COMPARTMENTS Subcellular localization image for TCF20 gene
Compartment Confidence
nucleus 5
mitochondrion 3

Gene Ontology (GO) - Cellular Components for TCF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10995766
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TCF20: view

Pathways for TCF20 Gene

genes like me logo Genes that share pathways with TCF20: view

Pathways by source for TCF20 Gene

Gene Ontology (GO) - Biological Process for TCF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 10995766
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with TCF20: view

Transcripts for TCF20 Gene

Unigene Clusters for TCF20 Gene

Transcription factor 20 (AR1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCF20 Gene

No ASD Table

Relevant External Links for TCF20 Gene

GeneLoc Exon Structure for
TCF20
ECgene alternative splicing isoforms for
TCF20

Expression for TCF20 Gene

mRNA expression in normal human tissues for TCF20 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCF20 Gene

SOURCE GeneReport for Unigene cluster for TCF20 Gene Hs.475018

mRNA Expression by UniProt/SwissProt for TCF20 Gene

Q9UGU0-TCF20_HUMAN
Tissue specificity: Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung
genes like me logo Genes that share expressions with TCF20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TCF20 Gene

Orthologs for TCF20 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF20 35
  • 99.37 (n)
  • 99.23 (a)
TCF20 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCF20 35
  • 87.69 (n)
  • 92.54 (a)
TCF20 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCF20 35
  • 89.75 (n)
  • 93.45 (a)
TCF20 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcf20 35
  • 88.68 (n)
  • 91.51 (a)
Tcf20 16
Tcf20 36
  • 91 (a)
OneToMany
Zfp957 36
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TCF20 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCF20 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcf20 35
  • 88.6 (n)
  • 91.03 (a)
chicken
(Gallus gallus)
Aves TCF20 35
  • 75.79 (n)
  • 77.45 (a)
TCF20 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCF20 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16860 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17635 35
tcf20 35
  • 60.91 (n)
  • 58.21 (a)
zebrafish
(Danio rerio)
Actinopterygii tcf20 36
  • 22 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5098 36
  • 16 (a)
OneToMany
Species with no ortholog for TCF20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCF20 Gene

ENSEMBL:
Gene Tree for TCF20 (if available)
TreeFam:
Gene Tree for TCF20 (if available)

Paralogs for TCF20 Gene

Paralogs for TCF20 Gene

genes like me logo Genes that share paralogs with TCF20: view

Variants for TCF20 Gene

Sequence variations from dbSNP and Humsavar for TCF20 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs134865 -- 42,254,321(+) TTTTT(-/CTTT)GTTTC intron-variant
rs134866 -- 42,254,657(+) ctata(C/T)cctgg intron-variant
rs134867 -- 42,255,215(+) gggca(C/T)ggtgc intron-variant
rs134868 -- 42,255,961(+) CTAAG(A/G)GCCCA intron-variant
rs134869 -- 42,256,068(+) CTCTC(A/G)TCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCF20 Gene

Variant ID Type Subtype PubMed ID
nsv834210 CNV Loss 17160897
nsv3643 CNV Insertion 18451855
nsv834211 CNV Loss 17160897

Relevant External Links for TCF20 Gene

HapMap Linkage Disequilibrium report
TCF20
Human Gene Mutation Database (HGMD)
TCF20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF20 Gene

Disorders for TCF20 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TCF20 Gene including...

Search for TCF20 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TCF20 Gene

Relevant External Links for TCF20

Genetic Association Database (GAD)
TCF20
Human Genome Epidemiology (HuGE) Navigator
TCF20
genes like me logo Genes that share disorders with TCF20: view

No data available for UniProtKB/Swiss-Prot for TCF20 Gene

Publications for TCF20 Gene

  1. Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization. (PMID: 9730594) Rajadhyaksha A. … Bina M. (Cytogenet. Cell Genet. 1998) 2 3 4 23
  2. The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators. (PMID: 10995766) Rekdal C. … Johansen T. (J. Biol. Chem. 2000) 2 3 4 23
  3. SPBP is a phosphoserine-specific repressor of estrogen receptor alpha. (PMID: 15831449) Gburcik V. … Picard D. (Mol. Cell. Biol. 2005) 3 23
  4. The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription. (PMID: 17913746) SjA … Johansen T. (Nucleic Acids Res. 2007) 3 23
  5. Chromosome 17q12 variants contribute to risk of early-onset prostate cancer. (PMID: 18701471) Levin A.M. … Douglas J.A. (Cancer Res. 2008) 3 48

Products for TCF20 Gene

Sources for TCF20 Gene

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