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Aliases for TCF19 Gene

Aliases for TCF19 Gene

  • Transcription Factor 19 2 3
  • SC1 3 4 6
  • Transcription Factor SC1 3 4
  • TCF-19 3 4

External Ids for TCF19 Gene

Previous GeneCards Identifiers for TCF19 Gene

  • GC06P031182
  • GC06P030897
  • GC06P031232
  • GC06P031234
  • GC06P031126

Summaries for TCF19 Gene

Entrez Gene Summary for TCF19 Gene

  • This gene encodes a protein that belongs to the Plant Homeo Domain finger family of transcription factors. The encoded protein is thought to function during the G1/S transition in the cell cycle. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for TCF19 Gene

TCF19 (Transcription Factor 19) is a Protein Coding gene. Diseases associated with TCF19 include tetraploidy. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for TCF19 Gene

  • Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression

Gene Wiki entry for TCF19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF19 Gene

Genomics for TCF19 Gene

Regulatory Elements for TCF19 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TCF19 Gene

Start:
31,158,526 bp from pter
End:
31,167,161 bp from pter
Size:
8,636 bases
Orientation:
Plus strand

Genomic View for TCF19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TCF19 Gene

  • Protein details for TCF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y242-TCF19_HUMAN
    Recommended name:
    Transcription factor 19
    Protein Accession:
    Q9Y242
    Secondary Accessions:
    • A6NCT8
    • B0UY11
    • Q0EFA8
    • Q13176
    • Q15967
    • Q5SQ89
    • Q5STD6
    • Q5STF5
    • Q9BUM2
    • Q9UBH7

    Protein attributes for TCF19 Gene

    Size:
    345 amino acids
    Molecular mass:
    37184 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB60363.1; Type=Frameshift; Positions=288, 290, 291; Evidence={ECO:0000305}; Sequence=AAB60363.1; Type=Frameshift; Positions=288; Evidence={ECO:0000305};

neXtProt entry for TCF19 Gene

Proteomics data for TCF19 Gene at MOPED

Post-translational modifications for TCF19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCF19 Gene

Antibody Products

No data available for DME Specific Peptides for TCF19 Gene

Domains for TCF19 Gene

Gene Families for TCF19 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

Suggested Antigen Peptide Sequences for TCF19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y242

UniProtKB/Swiss-Prot:

TCF19_HUMAN :
  • Q9Y242
Domain:
  • Contains 1 FHA domain.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with TCF19: view

Function for TCF19 Gene

Molecular function for TCF19 Gene

GENATLAS Biochemistry: transcription factor 19,SC1,late growth-regulated gene
UniProtKB/Swiss-Prot Function: Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression

Gene Ontology (GO) - Molecular Function for TCF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 1868030
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TCF19: view

Animal Model Products

CRISPR Products

miRNA for TCF19 Gene

miRTarBase miRNAs that target TCF19

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCF19

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TCF19 Gene

Localization for TCF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF19 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCF19 Gene COMPARTMENTS Subcellular localization image for TCF19 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TCF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCF19: view

Pathways for TCF19 Gene

genes like me logo Genes that share pathways with TCF19: view

Pathways by source for TCF19 Gene

Gene Ontology (GO) - Biological Process for TCF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 1868030
GO:0008283 cell proliferation TAS 1868030
genes like me logo Genes that share ontologies with TCF19: view

Transcripts for TCF19 Gene

Unigene Clusters for TCF19 Gene

Transcription factor 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCF19

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCF19 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5:
SP6: -

Relevant External Links for TCF19 Gene

GeneLoc Exon Structure for
TCF19
ECgene alternative splicing isoforms for
TCF19

Expression for TCF19 Gene

mRNA expression in normal human tissues for TCF19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TCF19 Gene

SOURCE GeneReport for Unigene cluster for TCF19 Gene Hs.584807

genes like me logo Genes that share expressions with TCF19: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TCF19 Gene

Orthologs for TCF19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCF19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF19 35
  • 98.94 (n)
  • 98.84 (a)
TCF19 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCF19 35
  • 86.63 (n)
  • 85.76 (a)
TCF19 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCF19 35
  • 85.27 (n)
  • 85.47 (a)
TCF19 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcf19 35
  • 81.3 (n)
  • 80.15 (a)
Tcf19 16
Tcf19 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCF19 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcf19 35
  • 82.58 (n)
  • 81.44 (a)
lizard
(Anolis carolinensis)
Reptilia TCF19 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcf19 35
  • 51.53 (n)
  • 43.25 (a)
zebrafish
(Danio rerio)
Actinopterygii tcf19l 35
  • 54.36 (n)
  • 50 (a)
tcf19l 36
  • 28 (a)
OneToOne
Species with no ortholog for TCF19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCF19 Gene

ENSEMBL:
Gene Tree for TCF19 (if available)
TreeFam:
Gene Tree for TCF19 (if available)

Paralogs for TCF19 Gene

No data available for Paralogs for TCF19 Gene

Variants for TCF19 Gene

Sequence variations from dbSNP and Humsavar for TCF19 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1841 -- 31,162,983(-) CAACA(C/T)GGCCT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1044870 -- 31,163,044(+) CATGC(C/T)TGCAA utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1065460 -- 31,162,723(+) GGTCC(A/G)CCGCC utr-variant-3-prime, intron-variant, nc-transcript-variant, downstream-variant-500B
rs1065461 -- 31,162,725(-) TTGGC(A/C/G)GTGGA utr-variant-3-prime, intron-variant, downstream-variant-500B, nc-transcript-variant
rs1419881 -- 31,162,816(-) CCCTC(C/T)TGGGG utr-variant-3-prime, intron-variant, splice-acceptor-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TCF19 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
dgv1918e1 CNV Complex 17122850
dgv1919e1 CNV Complex 17122850
nsv428140 CNV Gain+Loss 18775914
esv690 CNV CNV 17122850
nsv525933 CNV Loss 19592680
nsv884137 CNV Loss 21882294
nsv524061 CNV Loss 19592680
nsv884138 CNV Loss 21882294

Relevant External Links for TCF19 Gene

HapMap Linkage Disequilibrium report
TCF19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF19 Gene

Disorders for TCF19 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TCF19 Gene including...

Search for TCF19 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TCF19 Gene

(2) Novoseek inferred disease relationships for TCF19 Gene

Disease -log(P) Hits PubMed IDs
sarcoma 28.4 1
tumors 0 1

Relevant External Links for TCF19

Genetic Association Database (GAD)
TCF19
Human Genome Epidemiology (HuGE) Navigator
TCF19
genes like me logo Genes that share disorders with TCF19: view

No data available for UniProtKB/Swiss-Prot for TCF19 Gene

Publications for TCF19 Gene

  1. A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor. (PMID: 1868030) Ku D.H. … Baserga R. (Cell Growth Differ. 1991) 2 3 4 23
  2. Genetic polymorphisms in the cell growth regulated gene, SC1 telomeric of the HLA-C gene and lack of association of psoriasis vulgaris. (PMID: 10777095) Teraoka Y. … Inoko H. (Tissue Antigens 2000) 3 4 23 48
  3. Feature mapping of the HLA class I region: localization of the POU5F1 and TCF19 genes. (PMID: 8595903) Krishnan B.R. … Chaplin D.D. (Genomics 1995) 2 3
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TCF19 Gene

Sources for TCF19 Gene

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