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Aliases for TCF19 Gene

Aliases for TCF19 Gene

  • Transcription Factor 19 2 3 5
  • Transcription Factor SC1 3 4
  • TCF-19 3 4
  • SC1 3 4

External Ids for TCF19 Gene

Previous GeneCards Identifiers for TCF19 Gene

  • GC06P031182
  • GC06P030897
  • GC06P031232
  • GC06P031234
  • GC06P031126

Summaries for TCF19 Gene

Entrez Gene Summary for TCF19 Gene

  • This gene encodes a protein that contains a PHD-type zinc finger domain and likely functions as a transcription factor. The encoded protein plays a role proliferation and apoptosis of pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for TCF19 Gene

TCF19 (Transcription Factor 19) is a Protein Coding gene. Diseases associated with TCF19 include Tetraploidy. Among its related pathways are ERK Signaling and WNT Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for TCF19 Gene

  • Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.

Gene Wiki entry for TCF19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF19 Gene

Genomics for TCF19 Gene

Regulatory Elements for TCF19 Gene

Enhancers for TCF19 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TCF19 on UCSC Golden Path with GeneCards custom track

Promoters for TCF19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCF19 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCF19 Gene

Chromosome:
6
Start:
31,158,526 bp from pter
End:
31,167,159 bp from pter
Size:
8,634 bases
Orientation:
Plus strand

Genomic View for TCF19 Gene

Genes around TCF19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TCF19 Gene

  • Protein details for TCF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y242-TCF19_HUMAN
    Recommended name:
    Transcription factor 19
    Protein Accession:
    Q9Y242
    Secondary Accessions:
    • A6NCT8
    • B0UY11
    • Q0EFA8
    • Q13176
    • Q15967
    • Q5SQ89
    • Q5STD6
    • Q5STF5
    • Q9BUM2
    • Q9UBH7

    Protein attributes for TCF19 Gene

    Size:
    345 amino acids
    Molecular mass:
    37184 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB60363.1; Type=Frameshift; Positions=288, 290, 291; Evidence={ECO:0000305}; Sequence=AAB60363.1; Type=Frameshift; Positions=288; Evidence={ECO:0000305};

neXtProt entry for TCF19 Gene

Proteomics data for TCF19 Gene at MOPED

Post-translational modifications for TCF19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCF19 Gene

No data available for DME Specific Peptides for TCF19 Gene

Domains & Families for TCF19 Gene

Gene Families for TCF19 Gene

Suggested Antigen Peptide Sequences for TCF19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y242

UniProtKB/Swiss-Prot:

TCF19_HUMAN :
  • Contains 1 FHA domain.
  • Contains 1 PHD-type zinc finger.
Domain:
  • Contains 1 FHA domain.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with TCF19: view

Function for TCF19 Gene

Molecular function for TCF19 Gene

GENATLAS Biochemistry:
transcription factor 19,SC1,late growth-regulated gene
UniProtKB/Swiss-Prot Function:
Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.

Gene Ontology (GO) - Molecular Function for TCF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TCF19: view
genes like me logo Genes that share phenotypes with TCF19: view

Animal Models for TCF19 Gene

MGI Knock Outs for TCF19:

Animal Model Products

miRNA for TCF19 Gene

miRTarBase miRNAs that target TCF19

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCF19 Gene

Localization for TCF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF19 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCF19 Gene COMPARTMENTS Subcellular localization image for TCF19 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TCF19 Gene

Pathways & Interactions for TCF19 Gene

genes like me logo Genes that share pathways with TCF19: view

Gene Ontology (GO) - Biological Process for TCF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation TAS 1868030
genes like me logo Genes that share ontologies with TCF19: view

No data available for SIGNOR curated interactions for TCF19 Gene

Drugs & Compounds for TCF19 Gene

(1) Drugs for TCF19 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nevirapine Approved Pharma 223
genes like me logo Genes that share compounds with TCF19: view

Transcripts for TCF19 Gene

Unigene Clusters for TCF19 Gene

Transcription factor 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCF19 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5:
SP6: -

Relevant External Links for TCF19 Gene

GeneLoc Exon Structure for
TCF19
ECgene alternative splicing isoforms for
TCF19

Expression for TCF19 Gene

mRNA expression in normal human tissues for TCF19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for TCF19 Gene Hs.584807

genes like me logo Genes that share expression patterns with TCF19: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TCF19 Gene

Orthologs for TCF19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCF19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TCF19 35
  • 86.63 (n)
  • 85.76 (a)
TCF19 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCF19 35
  • 85.27 (n)
  • 85.47 (a)
TCF19 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcf19 35
  • 81.3 (n)
  • 80.15 (a)
Tcf19 16
Tcf19 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TCF19 35
  • 98.94 (n)
  • 98.84 (a)
TCF19 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcf19 35
  • 82.58 (n)
  • 81.44 (a)
oppossum
(Monodelphis domestica)
Mammalia TCF19 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCF19 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcf19 35
  • 51.53 (n)
  • 43.25 (a)
zebrafish
(Danio rerio)
Actinopterygii tcf19l 35
  • 54.36 (n)
  • 50 (a)
tcf19l 36
  • 28 (a)
OneToOne
Species with no ortholog for TCF19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCF19 Gene

ENSEMBL:
Gene Tree for TCF19 (if available)
TreeFam:
Gene Tree for TCF19 (if available)

Paralogs for TCF19 Gene

No data available for Paralogs for TCF19 Gene

Variants for TCF19 Gene

Sequence variations from dbSNP and Humsavar for TCF19 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2073721 - 31,161,839(+) GGGAA(A/G)TGGGG reference, missense
rs2073724 - 31,161,930(+) GCCTC(C/T)TGAGA reference, missense
rs7750641 - 31,161,533(+) AAGGG(C/T)CCCCA reference, missense
rs1044870 -- 31,163,044(+) CATGC(C/T)TGCAA utr-variant-3-prime
rs1065460 -- 31,162,723(+) GGTCC(A/G)CCGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TCF19 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
dgv1918e1 CNV Complex 17122850
dgv1919e1 CNV Complex 17122850
nsv428140 CNV Gain+Loss 18775914
esv690 CNV CNV 17122850
nsv525933 CNV Loss 19592680
nsv884137 CNV Loss 21882294
nsv524061 CNV Loss 19592680
nsv884138 CNV Loss 21882294

Variation tolerance for TCF19 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TCF19 Gene

Disorders for TCF19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCF19 Gene - From: GeneCards

Disorder Aliases PubMed IDs
tetraploidy
  • tetraploidy syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TCF19 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCF19

Genetic Association Database (GAD)
TCF19
Human Genome Epidemiology (HuGE) Navigator
TCF19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCF19
genes like me logo Genes that share disorders with TCF19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCF19 Gene

Publications for TCF19 Gene

  1. Genetic polymorphisms in the cell growth regulated gene, SC1 telomeric of the HLA-C gene and lack of association of psoriasis vulgaris. (PMID: 10777095) Teraoka Y. … Inoko H. (Tissue Antigens 2000) 3 4 23 48 67
  2. A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor. (PMID: 1868030) Ku D.H. … Baserga R. (Cell Growth Differ. 1991) 2 3 23
  3. Feature mapping of the HLA class I region: localization of the POU5F1 and TCF19 genes. (PMID: 8595903) Krishnan B.R. … Chaplin D.D. (Genomics 1995) 2 3
  4. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. (PMID: 24509480) . … Morris A.P. (Nat. Genet. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for TCF19 Gene

Sources for TCF19 Gene

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