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Aliases for TCF19 Gene

Aliases for TCF19 Gene

  • Transcription Factor 19 2 3 5
  • Transcription Factor SC1 3 4
  • TCF-19 3 4
  • SC1 3 4

External Ids for TCF19 Gene

Previous GeneCards Identifiers for TCF19 Gene

  • GC06P031182
  • GC06P030897
  • GC06P031232
  • GC06P031234
  • GC06P031126
  • GC06P031159
  • GC06P031162

Summaries for TCF19 Gene

Entrez Gene Summary for TCF19 Gene

  • This gene encodes a protein that contains a PHD-type zinc finger domain and likely functions as a transcription factor. The encoded protein plays a role proliferation and apoptosis of pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for TCF19 Gene

TCF19 (Transcription Factor 19) is a Protein Coding gene. Diseases associated with TCF19 include Peeling Skin Syndrome. Among its related pathways are Human Embryonic Stem Cell Pluripotency and PAK Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for TCF19 Gene

  • Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.

Gene Wiki entry for TCF19 Gene

Additional gene information for TCF19 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF19 Gene

Genomics for TCF19 Gene

Regulatory Elements for TCF19 Gene

Enhancers for TCF19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H031567 2 FANTOM5 Ensembl ENCODE dbSUPER 31.6 +419.9 419893 22 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B TNF DDX39B LY6G5B ATF6B LSM2 TCF19 MDC1 DHX16 NFKBIL1 C6orf47
GH06H031538 1.4 ENCODE dbSUPER 44.6 +382.6 382613 4 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 MCM3 PPARGC1A MEF2D ATF6B LSM2 LY6G5B DDX39B MDC1 PPP1R10 NRM DHX16 MSH5 TCF19
GH06H031545 1.2 ENCODE 36.4 +389.0 389007 3 MLX YBX1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D DDX39B LSM2 LY6G5B ATF6B DHX16 MDC1 NRM TCF19 NFKBIL1 MICA
GH06H030746 2 FANTOM5 Ensembl ENCODE dbSUPER 21.8 -407.1 -407099 9 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 ZNF766 FOS DEK PAF1 MDC1 IER3 GTF2H4 ENSG00000233892 LY6G5B DHX16 DDX39B TRIM39 PPP1R10 HLA-K
GH06H031733 1.9 FANTOM5 ENCODE dbSUPER 22.7 +578.9 578929 8 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 SP3 NFYC ZC3H11A LY6G5B ATF6B DDX39B LSM2 CSNK2B GPANK1 VARS NFKBIL1 SKIV2L MSH5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCF19 on UCSC Golden Path with GeneCards custom track

Promoters for TCF19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195503 -26 1801 HDGF PKNOX1 ZFP64 ARID4B SIN3A YY1 ZNF143 ZNF207 FOS SP3

Genomic Location for TCF19 Gene

Chromosome:
6
Start:
31,158,526 bp from pter
End:
31,167,159 bp from pter
Size:
8,634 bases
Orientation:
Plus strand

Genomic View for TCF19 Gene

Genes around TCF19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TCF19 Gene

  • Protein details for TCF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y242-TCF19_HUMAN
    Recommended name:
    Transcription factor 19
    Protein Accession:
    Q9Y242
    Secondary Accessions:
    • A6NCT8
    • B0UY11
    • Q0EFA8
    • Q13176
    • Q15967
    • Q5SQ89
    • Q5STD6
    • Q5STF5
    • Q9BUM2
    • Q9UBH7

    Protein attributes for TCF19 Gene

    Size:
    345 amino acids
    Molecular mass:
    37184 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB60363.1; Type=Frameshift; Positions=288, 290, 291; Evidence={ECO:0000305}; Sequence=AAB60363.1; Type=Frameshift; Positions=288; Evidence={ECO:0000305};

neXtProt entry for TCF19 Gene

Post-translational modifications for TCF19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCF19 Gene

No data available for DME Specific Peptides for TCF19 Gene

Domains & Families for TCF19 Gene

Gene Families for TCF19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TCF19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TCF19: view

No data available for UniProtKB/Swiss-Prot for TCF19 Gene

Function for TCF19 Gene

Molecular function for TCF19 Gene

GENATLAS Biochemistry:
transcription factor 19,SC1,late growth-regulated gene
UniProtKB/Swiss-Prot Function:
Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.

Phenotypes From GWAS Catalog for TCF19 Gene

Gene Ontology (GO) - Molecular Function for TCF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 1868030
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TCF19: view
genes like me logo Genes that share phenotypes with TCF19: view

Animal Models for TCF19 Gene

MGI Knock Outs for TCF19:

Animal Model Products

CRISPR Products

miRNA for TCF19 Gene

miRTarBase miRNAs that target TCF19

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCF19 Gene

Localization for TCF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF19 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCF19 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TCF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCF19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCF19 Gene

Pathways & Interactions for TCF19 Gene

genes like me logo Genes that share pathways with TCF19: view

Gene Ontology (GO) - Biological Process for TCF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 1868030
GO:0008283 cell proliferation TAS 1868030
genes like me logo Genes that share ontologies with TCF19: view

No data available for SIGNOR curated interactions for TCF19 Gene

Drugs & Compounds for TCF19 Gene

(1) Drugs for TCF19 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nevirapine Approved Pharma 225
genes like me logo Genes that share compounds with TCF19: view

Transcripts for TCF19 Gene

Unigene Clusters for TCF19 Gene

Transcription factor 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCF19 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5:
SP6: -

Relevant External Links for TCF19 Gene

GeneLoc Exon Structure for
TCF19
ECgene alternative splicing isoforms for
TCF19

Expression for TCF19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCF19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TCF19 Gene:

TCF19

SOURCE GeneReport for Unigene cluster for TCF19 Gene:

Hs.584807

Evidence on tissue expression from TISSUES for TCF19 Gene

  • Skin(4.3)
  • Intestine(4.2)
  • Blood(4.1)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with TCF19: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF19 Gene

Orthologs for TCF19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCF19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF19 33 34
  • 98.94 (n)
cow
(Bos Taurus)
Mammalia TCF19 33 34
  • 86.63 (n)
dog
(Canis familiaris)
Mammalia TCF19 33 34
  • 85.27 (n)
rat
(Rattus norvegicus)
Mammalia Tcf19 33
  • 82.58 (n)
mouse
(Mus musculus)
Mammalia Tcf19 33 16 34
  • 81.3 (n)
oppossum
(Monodelphis domestica)
Mammalia TCF19 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCF19 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcf19 33
  • 51.53 (n)
zebrafish
(Danio rerio)
Actinopterygii tcf19l 33 34
  • 54.36 (n)
Species where no ortholog for TCF19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCF19 Gene

ENSEMBL:
Gene Tree for TCF19 (if available)
TreeFam:
Gene Tree for TCF19 (if available)

Paralogs for TCF19 Gene

genes like me logo Genes that share paralogs with TCF19: view

No data available for Paralogs for TCF19 Gene

Variants for TCF19 Gene

Sequence variations from dbSNP and Humsavar for TCF19 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000226564 -- 31,158,753(+) GAGTG(C/G)GAAAA intron-variant, upstream-variant-2KB
rs1000507363 -- 31,158,499(+) AACGG(C/T)ACGGG upstream-variant-2KB
rs1000615578 -- 31,164,140(+) GGGCA(A/G)AAGTT downstream-variant-500B, utr-variant-3-prime
rs1000654068 -- 31,158,477(+) ACACA(A/T)GAGCT upstream-variant-2KB
rs1001481045 -- 31,157,529(+) CAGCA(A/G)GCCAT intron-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TCF19 Gene

Variant ID Type Subtype PubMed ID
dgv1174e214 CNV gain 21293372
esv2731791 CNV deletion 23290073
esv2759414 CNV gain+loss 17122850
esv3411275 CNV duplication 20981092
esv3608531 CNV loss 21293372
esv3608532 CNV gain 21293372
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv428140 CNV gain+loss 18775914
nsv524061 CNV loss 19592680
nsv525933 CNV loss 19592680
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv970105 CNV duplication 23825009

Variation tolerance for TCF19 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCF19 Gene

Human Gene Mutation Database (HGMD)
TCF19
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCF19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF19 Gene

Disorders for TCF19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCF19 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
peeling skin syndrome
  • peeling skin syndrome 1
- elite association - COSMIC cancer census association via MalaCards
Search TCF19 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCF19

Genetic Association Database (GAD)
TCF19
Human Genome Epidemiology (HuGE) Navigator
TCF19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCF19
genes like me logo Genes that share disorders with TCF19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCF19 Gene

Publications for TCF19 Gene

  1. Genetic polymorphisms in the cell growth regulated gene, SC1 telomeric of the HLA-C gene and lack of association of psoriasis vulgaris. (PMID: 10777095) Teraoka Y … Inoko H (Tissue antigens 2000) 3 4 22 45 60
  2. A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor. (PMID: 1868030) Ku DH … Baserga R (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991) 2 3 4 22 60
  3. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E … Dorak MT (Molecular human reproduction 2010) 3 45 60
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 45 60
  5. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PMID: 16702430) Shiina T … Bahram S (Genetics 2006) 3 4 60

Products for TCF19 Gene

Sources for TCF19 Gene

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