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Aliases for TCF15 Gene

Aliases for TCF15 Gene

  • Transcription Factor 15 (Basic Helix-Loop-Helix) 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 40 3 4
  • Protein BHLH-EC2 3 4
  • PARAXIS 3 4
  • BHLHa40 3 4
  • TCF-15 3 4
  • Basic Helix-Loop-Helix Transcription Factor 15 3
  • BHLHEC2 4
  • EC2 3

External Ids for TCF15 Gene

Previous GeneCards Identifiers for TCF15 Gene

  • GC20M000572
  • GC20M000579
  • GC20M000532
  • GC20M000584

Summaries for TCF15 Gene

Entrez Gene Summary for TCF15 Gene

  • The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCF15 Gene

TCF15 (Transcription Factor 15 (Basic Helix-Loop-Helix)) is a Protein Coding gene. Among its related pathways are ERK Signaling and WNT Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is LYL1.

UniProtKB/Swiss-Prot for TCF15 Gene

  • May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF15 Gene

Genomics for TCF15 Gene

Regulatory Elements for TCF15 Gene

Enhancers for TCF15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TCF15 on UCSC Golden Path with GeneCards custom track

Promoters for TCF15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCF15 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCF15 Gene

603,797 bp from pter
610,398 bp from pter
6,602 bases
Minus strand

Genomic View for TCF15 Gene

Genes around TCF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF15 Gene

Proteins for TCF15 Gene

  • Protein details for TCF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor 15
    Protein Accession:
    Secondary Accessions:
    • Q9NQQ1

    Protein attributes for TCF15 Gene

    199 amino acids
    Molecular mass:
    20816 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.

neXtProt entry for TCF15 Gene

Proteomics data for TCF15 Gene at MOPED

Post-translational modifications for TCF15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCF15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCF15 Gene

Domains & Families for TCF15 Gene

Gene Families for TCF15 Gene

Protein Domains for TCF15 Gene

Suggested Antigen Peptide Sequences for TCF15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with TCF15: view

Function for TCF15 Gene

Molecular function for TCF15 Gene

GENATLAS Biochemistry:
transcription factor 15,expressed in early mesoderma and developing somites in the mouse embryo
UniProtKB/Swiss-Prot Function:
May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.
genes like me logo Genes that share phenotypes with TCF15: view

Animal Models for TCF15 Gene

MGI Knock Outs for TCF15:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCF15 Gene

Localization for TCF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF15 Gene

Subcellular locations from

Jensen Localization Image for TCF15 Gene COMPARTMENTS Subcellular localization image for TCF15 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2
cytoskeleton 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TCF15 Gene

Pathways & Interactions for TCF15 Gene

genes like me logo Genes that share pathways with TCF15: view

Interacting Proteins for TCF15 Gene

Gene Ontology (GO) - Biological Process for TCF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001756 somitogenesis IEA --
GO:0003016 respiratory system process IEA --
GO:0007498 mesoderm development TAS 8041747
GO:0007517 muscle organ development IEA --
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with TCF15: view

No data available for SIGNOR curated interactions for TCF15 Gene

Drugs & Compounds for TCF15 Gene

No Compound Related Data Available

Transcripts for TCF15 Gene

mRNA/cDNA for TCF15 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCF15 Gene

Transcription factor 15 (basic helix-loop-helix):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCF15 Gene

No ASD Table

Relevant External Links for TCF15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCF15 Gene

mRNA expression in normal human tissues for TCF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCF15 Gene

This gene is overexpressed in Heart - Left Ventricle (x12.3), Adipose - Visceral (Omentum) (x4.7), and Heart - Atrial Appendage (x4.6).

Protein differential expression in normal tissues from HIPED for TCF15 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCF15 Gene

SOURCE GeneReport for Unigene cluster for TCF15 Gene Hs.437

genes like me logo Genes that share expression patterns with TCF15: view

Protein tissue co-expression partners for TCF15 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TCF15 Gene

Orthologs for TCF15 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TCF15 35
  • 93.4 (n)
  • 93.4 (a)
TCF15 36
  • 94 (a)
(Canis familiaris)
Mammalia TCF15 35
  • 94.64 (n)
  • 94.47 (a)
TCF15 36
  • 95 (a)
(Mus musculus)
Mammalia Tcf15 35
  • 90.6 (n)
  • 92.31 (a)
Tcf15 16
Tcf15 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Tcf15 35
  • 90.94 (n)
  • 92.82 (a)
(Monodelphis domestica)
Mammalia TCF15 36
  • 74 (a)
(Gallus gallus)
Aves TCF15 35
  • 77.96 (n)
  • 76.5 (a)
TCF15 36
  • 79 (a)
(Anolis carolinensis)
Reptilia TCF15 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733229 35
  • 72.54 (n)
  • 72.96 (a)
Str.11266 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15926 35
(Danio rerio)
Actinopterygii par1 35
  • 65.17 (n)
  • 66.29 (a)
par1 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33557 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea hlh-8 36
  • 25 (a)
Species with no ortholog for TCF15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCF15 Gene

Gene Tree for TCF15 (if available)
Gene Tree for TCF15 (if available)

Paralogs for TCF15 Gene

Paralogs for TCF15 Gene

(9) SIMAP similar genes for TCF15 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TCF15: view

Variants for TCF15 Gene

Sequence variations from dbSNP and Humsavar for TCF15 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs183989 -- 610,256(-) CACGG(A/C/G/T)GGGAC utr-variant-5-prime
rs188157 -- 610,079(+) ccccc(G/T)gggcc reference, synonymous-codon
rs282162 -- 606,311(-) ACTTA(A/C)AGAGT intron-variant
rs282163 -- 607,445(-) CTTTG(G/T)GGGCC intron-variant
rs282164 -- 609,812(-) TTCCG(A/C/G/T)GCCGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TCF15 Gene

Variant ID Type Subtype PubMed ID
nsv469833 CNV Gain 16826518
nsv833891 CNV Gain+Loss 17160897
nsv458844 CNV Loss 19166990
nsv912569 CNV Loss 21882294
nsv458845 CNV Loss 19166990
dgv4510n71 CNV Loss 21882294
dgv4511n71 CNV Loss 21882294
nsv912573 CNV Loss 21882294
nsv828661 CNV Gain 20364138

Variation tolerance for TCF15 Gene

Gene Damage Index Score: 2.91; 48.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TCF15 Gene

Disorders for TCF15 Gene

Relevant External Links for TCF15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TCF15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCF15 Gene

Publications for TCF15 Gene

  1. Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites. (PMID: 8041747) Quertermous E.E. … Quertermous T. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 67
  2. Genomic organization and chromosomal localization of the gene TCF15 encoding the early mesodermal basic helix-loop-helix factor bHLH-EC2. (PMID: 8825648) Hidai H. … Quertermous T. (Genomics 1995) 2 3 23
  3. Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake. (PMID: 25561514) Coppiello G. … Luttun A. (Circulation 2015) 3
  4. Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population. (PMID: 26428460) Yang W.Y. … Staessen J.A. (BMC Genet. 2015) 3
  5. A cohesin-RAD21 interactome. (PMID: 22145905) Panigrahi A.K. … Pati D. (Biochem. J. 2012) 3

Products for TCF15 Gene

Sources for TCF15 Gene