TCF15 Gene
protein-coding GIFtS : 48
GCID: GC20 M000532
transcription factor 15 (basic helix-loop-helix)
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Aliasesfor TCF15 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section This gene clusters with an RNA geneSubcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases Transcription Factor 15 (Basic Helix-Loop-Helix) 1 2 TCF-152 3 BHLHa401 Basic Helix-Loop-Helix Transcription Factor 152 EC21 2 Transcription Factor 152 PARAXIS1 2 BHLHA403 Class A Basic Helix-Loop-Helix Protein 402 3 BHLHEC23 Protein BHLH-EC22 3 Paraxis3
External Ids: HGNC: 11627 1 Entrez Gene: 6939 2 Ensembl: ENSG00000125878 7 OMIM: 601010 5 UniProtKB: Q12870 3 ORGUL members: NONCODE:n339549
Export aliases for TCF15 gene to outside databases Previous GC identifers: GC20M000572 GC20M000579
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Summariesfor TCF15 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for TCF15 : The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: TCF15_HUMAN, Q12870 Function : May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineagedetermination of cell types derived from the mesoderm
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Genomic Viewsfor TCF15 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000020.10 NC_018931.1 NT_011387.8 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TCF15 gene promoter: RORalpha1 E2F-1 FOXO4 p300 IRF-7A MyoD IRF-1 Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for TCF15 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TCF15
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13 TCF15 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20M000532: view genomic region
(about GC identifiers )
Start:
584,441 bp from pter
End:
591,042 bp from pter
Size:
6,602 bases
Orientation:
minus strand
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Proteinsfor TCF15 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TCF15_HUMAN, Q12870 (See
protein sequence )Recommended Name: Transcription factor 15 Size : 199 amino acids; 20816 Da
Subunit : Efficient DNA binding requires dimerization with another bHLH protein (By similarity)
Subcellular location : Nucleus (By similarity)
Secondary accessions : Q9NQQ1Explore the universe of human proteins at neXtProt for TCF15: NX_Q12870 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q12870 TCF15 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_004600.2 ENSEMBL proteins: ENSP00000246080 Human Recombinant Protein Products for TCF15: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
TCF15 for ontologies About GeneDecksing TCF15 Antibody Products: Assay Products for TCF15:
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Protein
Domains / Familiesfor TCF15 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TCF15 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q12870 ProtoNet protein and cluster: Q12870
1 Blocks protein family : IPB001092 Basic helix-loop-helix dimerization domain bHLH UniProtKB/Swiss-Prot: TCF15_HUMAN, Q12870 Similarity : Contains 1 bHLH (basic helix-loop-helix) domain
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Functionfor TCF15 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: TCF15_HUMAN, Q12870 Function : May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineagedetermination of cell types derived from the mesoderm
Genatlas biochemistry entry for TCF15 : transcription factor 15,expressed in early mesoderma and developing somites in the mouse embryo Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
IEA -- GO:0003700 sequence-specific DNA binding transcription factor activity
TAS 8825648 GO:0046983 protein dimerization activity
IEA --
TCF15 for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for TCF15 : 11 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tcf15) :
TCF15 for phenotypes About GeneDecksing Animal Models: Mouse knock-out Tcf15 tm1Eno for TCF15Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TCF15 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TCF15OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TCF15 (NM_004609 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCF15 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TCF15
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Pathways & Interactionsfor TCF15 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Human Embryonic Stem Cell Pluripotency 2 Rho Family GTPases 3 WNT Signaling 4 TGF-Beta Pathway 5 PAK Pathway
5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCF15 (see all 7 )Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCF15 Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17 ): About this table
TCF15 for ontologies About GeneDecksing
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Drugs & Compoundsfor TCF15 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TCF15 Search CenterWatch for drugs/clinical trials and news about TCF15
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Transcriptsfor TCF15 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TCF15 gene: NM_004609.3 Unigene Cluster for TCF15:
Transcription factor 15 (basic helix-loop-helix) Hs.437 [show with all ESTs ] Unigene Representative Sequence: NM_004609 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000246080 (uc002wdz.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TCF15 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TCF15OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TCF15 (NM_004609 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCF15 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TCF15
Additional cDNA sequence: U08336.1
1 DOTS entry : DT.204030
21 AceView cDNA sequences :
AA248660 AI377817 AI218364 BM665510 AI086393 AI377586 AW290965 AI699315 NM_004609 AI452773 AI393227 AI452694 BC067836 BV191902 BV190930 U08336 AI801955 AI183604 BF223969 BM711595 BG149324 GeneLoc Exon Structure
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Expression for TCF15 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TCF15 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCCTGTTCCGAbout this image TCF15 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See TCF15 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TCF15 SOURCE GeneReport for Unigene cluster: Hs.437 SABiosciences Expression via Pathway-Focused PCR Array including TCF15 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TCF15Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TCF15 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TCF15 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TCF15
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Orthologsfor TCF15 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for TCF15 gene from 5/15 species (see all 15 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
TCF151
transcription factor 15 (basic helix-loop-helix)
79.78(n) 78.14(a)
 
395788 NM_204946.2 NP_990277.1
lizard (Anolis carolinensis)
Reptilia
TCF156
--
75(a)
1 ↔ 1
GL343346.1(169838-170308)
African clawed frog (Xenopus laevis)
Amphibia
Xl.159262
Xenopus laevis transcribed sequence with weak similarity to protein pirA57717 (H.sapiens) A57717 transcription factor EC2 - human less
78.81(n)
 
BJ029684.1
zebrafish (Danio rerio)
Actinopterygii
par12
paraxis
80.17(n)
 
30159 AJ006310.1
fruit fly (Drosophila melanogaster)
Insecta
CG335576
--
37(a)
1 → many
X(9903268-9903886)
ENSEMBL Gene Tree for TCF15 (if available)TreeFam Gene Tree for TCF15 (if available)
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Paralogsfor TCF15 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TCF15 gene TCF24 2 NHLH1 2 TWIST1 2 TWIST2 2 TAL1 2 HAND2 2 TCF23 2 LYL1 2 NHLH2 2 TAL2 2 SCXB 2 TCF21 2 HAND1 2 MSC 2 SCXA 2 9 SIMAP similar genes for TCF15 using alignment to 3 protein entries: TCF15_HUMAN (see all proteins ):NHLH2 SCXA SCXB TAL2 TWIST2 ATOH7 HAND2 TCF21 NHLH1
TCF15 for paralogs About GeneDecksing
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Genomic Variantsfor TCF15 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 20 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TCF15 (584441 - 591042 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for TCF15 2 CNVs : 2250 5120
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TCF15
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Disorders
/ Diseasesfor TCF15 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TCF15 for disorders About MalaCards
TCF15 for disorders About GeneDecksing
OMIM gene information: 601010
OMIM disorders : --Export disorders for TCF15 gene to outside databases
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Publicationsfor TCF15 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TCF15 gene, integrated from 9 sources (see all 15 ): (articles sorted by number of sources associating them with TCF15) Utopia : connect your pdf to the dynamic world of online information
Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites. (PubMed id 8041747) 1 , 2 , 3 Quertermous E.E....Quertermous T. (1994) Genomic organization and chromosomal localization of the gene TCF15 encoding the early mesodermal basic helix-loop-helix factor bHLH-EC2. (PubMed id 8825648) 1 , 3, 9 Hidai H....Quertermous T. (1995) The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052) 1 , 2 Deloukas P....Rogers J. (2001) A cohesin-RAD21 interactome. (PubMed id 22145905) 1 Panigrahi A.K....Pati D. (2012) Acetylation of KLF5 alters the assembly of p15 transc ription factors in transforming growth factor-beta-mediated induction in epithe lial cells. (PubMed id 19419955) 1 Guo P....Dong J.T. (2009) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Xenopus paraxis homologue shows novel domains of expression. (PubMed id 15376281) 9 Carpio R....Mayor R. (2004) Regulation of paraxis expression and somite formation by ectoderm- and neural tube-derived signals. (PubMed id 9187085) 9 Sosic D....Olson E.N. (1997) Identification and developmental expression of Xenopus paraxis. (PubMed id 15602702) 9 Tseng H.T. and Jamrich M. (2004) beta-Catenin-dependent Wnt signalling controls the epithelial organisation of somites through the activation of paraxis. (PubMed id 16100089) 9 Linker C....Marcelle C. (2005)
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External Searches for TCF15 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TCF15 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TCF15 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TCF15 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TCF15 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TCF15 gene: Search GeneIP for patents involving TCF15 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TCF15 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TCF15 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TCF15 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TCF15 OriGene Protein Over-expression Lysate for TCF15 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TCF15 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TCF15 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TCF15 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TCF15 OriGene Custom Protein Services for TCF15 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCF15 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TCF15 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TCF15 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TCF15 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TCF15 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TCF15
Search Tocris compounds for TCF15
TCF15 Proteins, Antibodies, CLIAs, and ELISAs
Search ThermoFisher Antibodies for TCF15
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TCF15
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Aliases for TCF15
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Expression for TCF15
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