Aliases for TCF12 Gene
External Ids for TCF12 Gene
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for TCF12 Gene
TCF12 (Transcription Factor 12) is a Protein Coding gene. Diseases associated with TCF12 include craniosynostosis 3 and isolated brachycephaly. Among its related pathways are L1CAM interactions and ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is TCF4.
UniProtKB/Swiss-Prot for TCF12 Gene
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3)