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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCF12 Gene

protein-coding   GIFtS: 63
GCID: GC15P057210

transcription factor 12
 Explore 16 diseases affiliated with
TCF12 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TCF12    

Aliases
for TCF12 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transcription Factor 121 2     Transcription Factor HTF-42 3
HTF41 2 3 5     TCF-122 3
HEB1 2 3     DNA-Binding Protein HTF42 3
BHLHb201     E-Box-Binding Protein2 3
HsT172661 2     Helix-Loop-Helix Transcription Factor 42
Class B Basic Helix-Loop-Helix Protein 202 3     BHLHB203

External Ids:    HGNC: 116231   Entrez Gene: 69382   Ensembl: ENSG000001402627   OMIM: 6004805   UniProtKB: Q990813   

Export aliases for TCF12 gene to outside databases

Previous GC identifers: GC15P052769 GC15P050257 GC15P054789 GC15P054926 GC15P054998 GC15P034034


Summaries
for TCF12 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TCF12:
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the
consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle,
thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of
heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been
described, but the full-length nature of some of these variants has not been determined. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: HTF4_HUMAN, Q99081
Function: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by
binding to the E box (5'-CANNTG-3')

Gene Wiki entry for TCF12


Genomic Views
for TCF12 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCF12 gene promoter:
         SRF   SRF (504 AA)   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TCF12 promoter sequence
   Search SABiosciences Chromatin IP Primers for TCF12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCF12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q21

TCF12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCF12 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P057210:  view genomic region     (about GC identifiers)

Start:
 57,210,821 bp from pter      End:
 57,591,479 bp from pter
Size:
 380,659 bases      Orientation:
 plus strand

Proteins
for TCF12 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HTF4_HUMAN, Q99081 (See protein sequence)
Recommended Name: Transcription factor 12  
Size: 682 amino acids; 72965 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with
myogenin, E12 and ITF2 proteins. Interacts with PTF1A. Interacts with NEUROD2 (By similarity). Interacts with RUNX1T1
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for TCF12:
2KNH (3D)    
Secondary accessions: Q7Z3D9 Q86TC1 Q86VM2
Alternative splicing: 3 isoforms:  Q99081-1   Q99081-2   Q99081-3   

Explore the universe of human proteins at neXtProt for TCF12: NX_Q99081

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99081

    • TCF12 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_003196.1  NP_996919.1  NP_996920.1  NP_996921.1  NP_996923.1  

    ENSEMBL proteins: 
     ENSP00000388940   ENSP00000267811   ENSP00000453876   ENSP00000331057   ENSP00000453737  
     ENSP00000454109   ENSP00000453653   ENSP00000440017   ENSP00000444696   ENSP00000342459  
     ENSP00000453264   ENSP00000454102   ENSP00000454823   ENSP00000456280   ENSP00000396881  
    Reactome Protein details: Q99081
    Human Recombinant Protein Products: 
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    Novus Biologicals TCF12 Proteins
    Novus Biologicals TCF12 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TCF12

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IEA--


    TCF12 for ontologies           About GeneDecksing



    TCF12 Antibody Products: 
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    Assay Products for TCF12: 
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    Uscn ELISAs and CLIAs for TCF12

    Protein Domains /
    Families
    for TCF12 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TCF12 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry Q99081

    ProtoNet protein and cluster: Q99081

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: HTF4_HUMAN, Q99081
    Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription
    factors
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for TCF12 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HTF4_HUMAN, Q99081
    Function: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by
    binding to the E box (5'-CANNTG-3')

         Genatlas biochemistry entry for TCF12:
    transcription factor 12,involved in differentiation of muscle cells and in regulation of gene expression during
    hematopoiesis

    miRNA
    Products:            		miRTarBase miRNAs that target TCF12:
    hsa-mir-204 (MIRT005845)

    OriGene 3'-UTR Clone (see all 5): TCF12
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCF12
    8/114 QIAGEN miScript miRNA Assays for microRNAs that regulate TCF12 (see all 114):
    hsa-miR-548j hsa-miR-607 hsa-miR-3146 hsa-miR-200a hsa-miR-1258 hsa-miR-219-5p hsa-miR-138-2* hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: TCF12 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCF12 (see all 7)
    OriGene shRNA RFP: TCF12
    OriGene siRNA: TCF12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCF12

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TCF12

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCF12 (see all 8)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): TCF12 (NM_003205)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCF12 

    Cell Line
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    Search LifeMap BioReagents cell lines for TCF12

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCF12

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA11802795
    GO:0005515protein binding IPI11802795
    GO:0016563transcription activator activity ----
    GO:0044212contributes to transcription regulatory region DNA binding IDA11802795


    TCF12 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Tcf12tm1Zhu for TCF12
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tcf12):
     behavior/neurological  cellular  growth/size  hematopoietic system  immune system 
     mortality/aging  nervous system 

    TCF12 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TCF12 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Human Embryonic Stem Cell Pluripotency
    		Human Embryonic Stem Cell Pluripotency1.00
    		Factors Promoting Cardiogenesis in Vertebrates0.50
    2Activation of p38 alpha/beta MAPK
    		CDO in myogenesis0.55
    		Myogenesis0.55
    3Rho Family GTPases
    		MAPK Signaling0.51
    		ILK Signaling0.45
    4Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00
    5Lymphocyte Signaling
    		Lymphocyte Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCF12 (see all 7)
        MAPK Signaling
    ILK Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Human Embryonic Stem Cell Pluripotency
    JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for TCF12
        Wnt / Hedgehog / Notch
    Lymphocyte Signaling

    1 BioSystems Pathway for TCF12 
        Id Signaling Pathway

    3        Reactome Pathways for TCF12
        Developmental Biology
    Myogenesis
    CDO in myogenesis



    TCF12 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCF12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for TCF12 (Q990812, 3 ENSP000003310574) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAL1P175422, 3, ENSP000002943394MINT-8142126 I2D: score=3 STRING: ENSP00000294339
    TCF3P159232, 3, ENSP000002629654MINT-8142126 I2D: score=2 STRING: ENSP00000262965
    RUNX1Q011962, 3, ENSP000003003054MINT-8142126 I2D: score=3 STRING: ENSP00000300305
    ID3Q025353, ENSP000003636894I2D: score=3 STRING: ENSP00000363689
    CBFA2T3O750813, ENSP000002686794I2D: score=1 STRING: ENSP00000268679
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8163514
    GO:0006955immune response TAS1312219
    GO:0007399nervous system development ----


    TCF12 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TCF12 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCF12
    Search CenterWatch for drugs/clinical trials and news about TCF12 / HTF4 

    Transcripts
    for TCF12 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TCF12 gene (5 alternative transcripts): 
    NM_003205.3  NM_207036.1  NM_207037.1  NM_207038.1  NM_207040.1  

    Unigene Cluster for TCF12:

    Transcription factor 12
    Hs.511504  [show with all ESTs]
    Unigene Representative Sequence: NM_207037
    18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000438423(uc002aea.3 uc002aeb.3) ENST00000267811(uc010bfs.3 uc002aec.3 uc002aed.3 uc010ugq.2)
    ENST00000558908 ENST00000559609 ENST00000560190 ENST00000333725 ENST00000557843(uc010ugm.1)
    ENST00000557947 ENST00000561152 ENST00000569880 ENST00000561346 ENST00000559216
    ENST00000560887 ENST00000561235 ENST00000560764 ENST00000543579 ENST00000537840
    ENST00000343827(uc002aee.3 uc010bft.3 uc010ugo.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 5): TCF12
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCF12
    8/114 QIAGEN miScript miRNA Assays for microRNAs that regulate TCF12 (see all 114):
    hsa-miR-548j hsa-miR-607 hsa-miR-3146 hsa-miR-200a hsa-miR-1258 hsa-miR-219-5p hsa-miR-138-2* hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: TCF12 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCF12 (see all 7)
    OriGene shRNA RFP: TCF12
    OriGene siRNA: TCF12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCF12
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCF12

    Additional cDNA sequence: 

    AK294617.1 AK294991.1 AK302749.1 AK302923.1 AK303028.1 AK304007.1 AK308101.1 AK310708.1 
    AK311359.1 AK311709.1 AK312710.1 AL831981.2 BC050556.1 BC051769.2 BX537967.1 M65209.1 
    M80627.1 M83233.1 

    24/27 DOTS entries (see all 27):

    DT.121029829  DT.101956112  DT.100823552  DT.91767506  DT.101965625  DT.97846916  DT.91669336  DT.91767505 
    DT.121029987  DT.121029905  DT.86996550  DT.75126795  DT.95124517  DT.100850811  DT.121029839  DT.121029910 
    DT.121029942  DT.40195798  DT.40272569  DT.87078934  DT.91767500  DT.92053636  DT.95138620  DT.97835783 

    24/347 AceView cDNA sequences (see all 347):

    BC051769 AI830764 BQ894394 NM_207040 AW237272 BX493109 BI492280 CA393781 
    AA447530 BG107466 AW068970 AA488366 BP365742 BX509161 AA488497 BG413517 
    AA446586 BM458922 BM469590 BM454444 BM543162 BU189963 BM015003 BI963008 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TCF12 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
    SP1:                                      -     -     -                       -     -                                         -     -                           
    SP2:                                      -     -                             -     -                                         -     -                           
    SP3:                                      -     -                             -     -                                         -     -                           
    SP4:                                      -     -     -                       -     -                                         -     -                           
    SP5:                                                                                                                                                            

    ExUns: 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
    SP1:              -                                         -     -                           
    SP2:              -                                         -     -                           
    SP3:              -           -                             -     -                           
    SP4:              -           -                             -     -                           
    SP5:              -           -                             -     -                           


    ECgene alternative splicing isoforms for TCF12

    Expression
    for TCF12 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCF12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTAAAGGAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TCF12 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Midbrain dopaminergic-like neurons (Generation of midbra...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TCF12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCF12

    SOURCE GeneReport for Unigene cluster: Hs.511504

    UniProtKB/Swiss-Prot: HTF4_HUMAN, Q99081
    Tissue specificity: Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line

        SABiosciences Custom PCR Arrays for TCF12
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    Orthologs
    for TCF12 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TCF12 gene from 6/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TCF121 transcription factor 12 83.39(n)
    88.74(a)    		   396334  NM_205375.2  NP_990706.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TCF126
    --
    		 --
    		 78(a)
    73(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343573.1(388289-434217)
    AAWZ02036688(11541-14447)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.81652 Xenopus laevis helix-loop-helix transcription factor more 82.58(n)    U25959.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii 570834532   -- 82.13(n)    57083453 
    fruit fly
    (Drosophila melanogaster)    		 Insecta da1 , 3 oogenesis transcription factor3
    daughterless1    		 65(a)3
    43.29(n)1
    41.67(a)1    		   344131  NM_057841.31  NP_477189.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea hlh-26
    		 Helix Loop Helix family member (hlh-2)
    		 23(a)
    		 1 → many
    		 I(7190846-7193914)


    ENSEMBL Gene Tree for TCF12 (if available)
    TreeFam Gene Tree for TCF12 (if available) 

    Paralogs
    for TCF12 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCF12 gene
    TCF42  TCF32  
    2 SIMAP similar genes for TCF12 using alignment to 20 protein entries:     HTF4_HUMAN (see all proteins):
    TCF4    TCF3

    TCF12 for paralogs           About GeneDecksing



    Genomic Variants
    for TCF12 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6838 NCBI SNPs in TCF12 are shown (see all 6838)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1477604741,2
    		--57208855(+) TGGTGA/GCAGAG 5 -- us2k1 int10--------
    rs58128591,2
    		C--57208875(+) AAAAA-/AGTCAC 5 -- int1 us2k1 trp31Minor allele frequency- A:0.00NA 2
    rs1848842491,2
    		--57208954(+) TAACCC/TGGCTA 5 -- int1 us2k10--------
    rs1488275861,2
    		--57208981(+) ATGGCC/TACCCA 5 -- int1 us2k10--------
    rs1425476151,2
    		--57209274(+) AAGGAA/GGAGTG 5 -- nc-transcript-variantus2k10--------
    rs1509643411,2
    		--57209596(+) AGATAC/TGATTT 5 -- int1 us2k10--------
    rs71647421,2
    		C,F,A,H,--57209618(+) GGAAAT/CACACC 5 -- us2k1 int123Minor allele frequency- C:0.36NS EA NA WA CSA 2341
    rs2005001051,2
    		--57209738(+) TCTAC-/CTCTCTT 5 -- us2k1 nc-transcript-variant0--------
    rs1902472371,2
    		--57209743(+) CTCTCG/TTTCCA 5 -- nc-transcript-variantus2k10--------
    rs727494051,2
    		C,F,--57209793(+) TCCTCG/AGGCGT 5 -- us2k1 nc-transcript-variant1Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for TCF12 (57210821 - 57460821 bp, first 250kb of TCF12)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TCF12
         2 Indels: 11794 60178

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    Disorders / Diseases
    for TCF12 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TCF12 for disorders           About GeneDecksing

    OMIM gene information: 600480    OMIM disorders: --

    16 diseases for TCF12:    About MalaCards
    diamond-blackfan anemia    human t-cell leukemia virus type 1    acute lymphoblastic leukemia    lymphoblastic leukemia
    dyslexia    t-cell leukemia    down syndrome    protein s deficiency
    leukemia    anemia    hematopoiesis    pharyngitis
    schizophrenia    immunodeficiency    thyroiditis    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for TCF12:
    Articulation disorder     Photokeratitis     Extraskeletal myxoid chondrosarcoma
    Human Genome Epidemiology (HuGE) Navigator: TCF12 (2 documents)

    Export disorders for TCF12 gene to outside databases

    Publications
    for TCF12 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCF12 gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with TCF12)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. HTF4: a new human helix-loop-helix protein. (PubMed id 1886779)1, 2, 3 Zhang Y.... Bina M. (1991)
    2. HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors. (PubMed id 1312219)1, 2, 9 Hu J.S.... Kingston R.E. (1992)
    3. Genomic organization of human TCF12 gene and spliced mRNA variants producing isoforms of transcription factor HTF4. (PubMed id 12826747)1, 2, 9 Gan T.I.... Bina M. (2002)
    4. The nucleotide sequence of the human transcription factor HTF4a cDNA. (PubMed id 1446075)1, 2 Zhang Y. and Bina M. (1992)
    5. CBFA2T3-ZNF652 corepressor complex regulates transcription of the E-box gene HEB. (PubMed id 18456661)1, 9 Kumar R....Callen D.F. (2008)
    6. Localization of the human HTF4 transcription factors 4 gene (TCF12) to chromosome 15q21. (PubMed id 7842744)1, 9 Zhang Y....Bina M. (1995)
    7. AML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets. (PubMed id 19043539)1, 9 Gardini A....Alcalay M. (2008)
    8. Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL. (PubMed id 12566462)1, 9 Tremblay M....Hoang T. (2003)
    9. Distinguishable patterns of protein-DNA interactions involving complexes of basic helix-loop-helix proteins. (PubMed id 8163514)1, 9 Doyle K....Bina M. (1994)
    10. NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)

    External Searches for TCF12 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TCF12 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6938 HGNC: 11623 AceView: TCF12 Ensembl:ENSG00000140262 euGenes: HUgn6938
    ECgene: TCF12 H-InvDB: TCF12

    Other Databases showing TCF12 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TCF12 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCF12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TCF12 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TCF12 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TCF12 gene:
    Search GeneIP for patents involving TCF12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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