Aliases for TCERG1 Gene
External Ids for TCERG1 Gene
Previous HGNC Symbols for TCERG1 Gene
Previous GeneCards Identifiers for TCERG1 Gene
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for TCERG1 Gene
TCERG1 (Transcription Elongation Regulator 1) is a Protein Coding gene. Diseases associated with TCERG1 include Huntington Disease and Aicardi-Goutieres Syndrome. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding and RNA polymerase II repressing transcription factor binding. An important paralog of this gene is PRPF40A.
UniProtKB/Swiss-Prot for TCERG1 Gene
Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.