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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TCERG1 Gene

protein-coding GIFtS: 56
GCID: GC05P145807

transcription elongation regulator 1

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2S)

Explore 9 diseases affiliated with
TCERG1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transcription Elongation Regulator 1¹ ²		TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, S, 150kD¹ ²
CA150¹ ² ³ ⁵		Transcription Factor CA150² ³
TAF2S¹ ² ³ ⁵		TATA Box-Binding Protein-Associated Factor 2S² ³
Urn1¹ ²		Co-Activator Of 150 KDa²

External Ids:	HGNC: 15630¹	Entrez Gene: 10915²	Ensembl: ENSG00000113649⁷	OMIM: 605409⁵	UniProtKB: O14776³

Export aliases for TCERG1 gene to outside databases

Previous GC identifers: GC05P145795 GC05P146408 GC05P145855 GC05P141093

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCERG1:

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded

protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and

with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants

encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TCRG1_HUMAN, O14776

Function: Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target

promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation

of the human immunodeficiency virus type 1 (HIV-1) promoter

Gene Wiki entry for TCERG1 (Transcription elongation regulator 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TCERG1 gene promoter:
RFX1 p53 Meis-1a Meis-1b Meis-1 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TCERG1 promoter sequence

Search SABiosciences Chromatin IP Primers for TCERG1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCERG1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q31

TCERG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCERG1 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P145807: view genomic region (about GC identifiers)

Start:	145,826,873 bp from pter	End:	145,891,524 bp from pter
Size:	64,652 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TCRG1_HUMAN, O14776 (See protein sequence)

Recommended Name: Transcription elongation regulator 1

Size: 1098 amino acids; 123901 Da

Subunit: Binds formin (By similarity). Binds RNA polymerase II, HD and SF1

Subcellular location: Nucleus

Sequence caution: Sequence=BAD93147.1; Type=Erroneous initiation;

6/9 PDB 3D structures from and Proteopedia for TCERG1 (see all 9):

2DK7 (3D)

2DOD (3D)

2DOE (3D)

2DOF (3D)

2E71 (3D)

2KIQ (3D)

Secondary accessions: Q2NKN2 Q59EA1

Alternative splicing: 2 isoforms: O14776-1 O14776-2

Explore the universe of human proteins at neXtProt for TCERG1: NX_O14776

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14776

TCERG1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001035095.1 NP_006697.2

ENSEMBL proteins:

ENSP00000296702 ENSP00000377943 ENSP00000450414

Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TCERG1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

TCERG1 for ontologies About GeneDecksing

TCERG1 Antibody Products:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TCERG1 for domains About GeneDecksing

2 InterPro domains/families:

IPR002713 FF_domain

IPR001202 WW_Rsp5_WWP

Graphical View of Domain Structure for InterPro Entry O14776

ProtoNet protein and cluster: O14776

UniProtKB/Swiss-Prot: TCRG1_HUMAN, O14776

Domain: The FF domains bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II, probably mediate

interaction with HTATSF1 and preferentially bind peptides with the consensus sequence [DE](2-5)-[FWY]-[DE](2-5)

Domain: The WW domains bind Pro-rich domains

Similarity: Contains 6 FF domains

Similarity: Contains 3 WW domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TCRG1_HUMAN, O14776

Function: Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target

promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation

of the human immunodeficiency virus type 1 (HIV-1) promoter

Induction: Up-regulated in brain tissue from patients with Huntington disease

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TCERG1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCERG1
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate TCERG1 (see all 17):
		hsa-miR-607 hsa-miR-181c hsa-miR-200a hsa-miR-141 hsa-miR-548g hsa-miR-3143 hsa-miR-330-3p hsa-miR-24

		SwitchGear 3'UTR luciferase reporter plasmid: TCERG1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for TCERG1

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCERG1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001103	RNA polymerase II repressing transcription factor binding	IPI	--
GO:0001106	RNA polymerase II transcription corepressor activity	IDA	--
GO:0003713	transcription coactivator activity	TAS	9315662
GO:0005515	protein binding	IPI	15383276
GO:0070064	proline-rich region binding	IEA	--

TCERG1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for TCERG1:

Decreased Hepatitis C virus re

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

Spliceosome

0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for TCERG1):

Spliceosome

TCERG1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TCERG1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/65 Interacting proteins for TCERG1 (O14776^{1, 2, 3} ENSP00000296702⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 65)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HTT	P42858¹^,²^,³, ENSP00000347184⁴	EBI-473271,EBI-466029 MINT-3977875 MINT-3978350 MINT-3978501 I2D: score=5 STRING: ENSP00000347184
CHD3	Q12873²^,³, ENSP00000369716⁴	MINT-3979001 I2D: score=4 STRING: ENSP00000369716
PIAS4	Q8N2W9²^,³, ENSP00000262971⁴	MINT-3979018 I2D: score=4 STRING: ENSP00000262971
SETDB1	Q15047²^,³, ENSP00000357965⁴	MINT-3979035 I2D: score=4 STRING: ENSP00000357965
SF3A2	Q15428²^,³, ENSP00000221494⁴	MINT-5206178 I2D: score=3 STRING: ENSP00000221494

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	9315662

TCERG1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TCERG1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TCERG1
1 Novoseek chemical compound relationship for TCERG1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glutamine	21	2	9315662 (1), 11172033 (1)

Search CenterWatch for drugs/clinical trials and news about TCERG1 / TCRG1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TCERG1 gene (2 alternative transcripts):

NM_001040006.1 NM_006706.3

Unigene Cluster for TCERG1:

Transcription elongation regulator 1

Hs.443465 [show with all ESTs]

Unigene Representative Sequence: NM_006706

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000507175(uc011dbt.2) ENST00000296702(uc003lob.3 uc003loc.3)

ENST00000394421 ENST00000549332 ENST00000513298 ENST00000510724 ENST00000509810

ENST00000515203 ENST00000506524 ENST00000505285 ENST00000504116 ENST00000509787

ENST00000514567 ENST00000514719 ENST00000503741 ENST00000511077

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TCERG1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCERG1
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate TCERG1 (see all 17):
		hsa-miR-607 hsa-miR-181c hsa-miR-200a hsa-miR-141 hsa-miR-548g hsa-miR-3143 hsa-miR-330-3p hsa-miR-24

		SwitchGear 3'UTR luciferase reporter plasmid: TCERG1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCERG1

Additional cDNA sequence:

AB209910.1 AF017789.1 AK126455.1 AK304319.1 BC006109.1 BC014151.2 BC015864.1 BC062351.1

BC111727.1

19 DOTS entries:

DT.100820288 DT.318176 DT.454594 DT.100802883 DT.439166 DT.92432274 DT.100024950 DT.97861907

DT.100024951 DT.91741504 DT.92432279 DT.95331046 DT.75133302 DT.91664930 DT.91957713 DT.95077019

DT.95210011 DT.91731885 DT.100019445

24/308 AceView cDNA sequences (see all 308):

BU622083 BE276879 BQ001609 R49441 T31740 BQ436501 BM838100 BM799350

BE350717 AA380703 AA653254 BG943061 AA054932 BX646813 AA449597 BC006109

BX106946 AI056107 BU622180 AI873633 CD678718 AA693568 AA355938 AL692077

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for TCERG1 (see all 16) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	^	11a	·	11b	^	12	^	13a	·	13b	·	13c	^	14	^	15a	·
SP1:																																											-
SP2:
SP3:
SP4:																																											-
SP5:					-

ExUns:	15b	·	15c	·	15d	^	16a	·	16b	^	17	^	18a	·	18b	^	19	^	20	^	21	^	22	^	23	^	24a	·	24b	^	25a	·	25b	^	26	^	27	^	28a	·	28b
SP1:
SP2:					-		-												-
SP3:																															-						-
SP4:
SP5:

ECgene alternative splicing isoforms for TCERG1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TCERG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGCCAGAA

About this image
See TCERG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCERG1

SOURCE GeneReport for Unigene cluster: Hs.443465

UniProtKB/Swiss-Prot: TCRG1_HUMAN, O14776

Tissue specificity: Detected in brain neurons

SABiosciences Custom PCR Arrays for TCERG1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TCERG1 gene from 9/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tcerg1^{1 , 5}	transcription elongation regulator 1 (CA150)^{1, 5}	91.71(n)¹ 97.81(a)¹		18 (22.66 cM)⁵ 56070¹ NM_001039474.1¹ NP_001034563.1¹ 42511510⁵
chicken (Gallus gallus)	Aves	TCERG1¹	transcription elongation regulator 1	81.88(n) 93.42(a)		416349 XM_414665.3 XP_414665.3
lizard (Anolis carolinensis)	Reptilia	TCERG1⁶	--	36(a)	possible ortholog	GL343234.1(456870-473716)
African clawed frog (Xenopus laevis)	Amphibia	Xl.5868²	Xenopus laevis, Similar to transcription elongation more	80.75(n)		BC046714.1
zebrafish (Danio rerio)	Actinopterygii	tcerg1²	transcription elongation regulator 1 (CA150)	74.13(n)		323071 BC056813.1
fruit fly (Drosophila melanogaster)	Insecta	CG42724¹	CG42724	46.34(n) 40.42(a)		40785 NM_001202255.1 NP_001189184.1
worm (Caenorhabditis elegans)	Secernentea	ZK1127.6³ tcer-1¹	Protein TCER-1¹	37(a) (best of 4)³ 51.3(n)¹ 40.94(a)¹		II(7042816-7044303)³ 174150¹ NM_063041.1¹ NP_495442.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	PRP40C¹	transcription elongation regulator 1	46.7(n) 32.79(a)		821521 NM_112874.3 NP_188618.3
rice (Oryza sativa)	Liliopsida	Os10g0485000¹	hypothetical protein	43.34(n) 30.58(a)		4348939 NM_001071428.1 NP_001064893.1

ENSEMBL Gene Tree for TCERG1 (if available)
TreeFam Gene Tree for TCERG1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TCERG1 gene

PRPF40B² PRPF40A² TCERG1L²

2 SIMAP similar genes for TCERG1 using alignment to 2 protein entries: TCRG1_HUMAN (see all proteins):

TCERG1L PRPF40B

TCERG1 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for TCERG1
PGOHUM00000248743 PGOHUM00000243236 PGOHUM00000241966

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2400217^1,2	C,	--	145824951(+)	`CTGGAC/TGTGGT`	2	--	us2k¹		11		NA WA CSA EA	372
rs181369669^1,2		--	145825346(+)	`CAGGCA/GGCCTT`	2	--	us2k¹		0	--	--	--	--
rs147430550^1,2	C,	--	145825393(+)	`TGTAC-/AGTT AGTTA`	2	--	us2k¹		0	--	--	--	--
rs186287024^1,2		--	145825403(+)	`ATACCA/CTGTTT`	2	--	us2k¹		0	--	--	--	--
rs6862771^1,2	C,F,H,	--	145825440(+)	`TCTGTC/TGCCCA`	2	--	us2k¹		6		NA WA CSA	11
rs149755125^1,2		--	145825630(+)	`GACCTC/TGTGAT`	2	--	us2k¹		0	--	--	--	--
rs2033474^1,2	C,F,A,H,	--	145825685(+)	`CCACCT/GCGCCC`	2	--	us2k¹		15		EA NS NA WA CSA	797
rs192139836^1,2		--	145825809(+)	`TGGATC/TCAATT`	2	--	us2k¹		0	--	--	--	--
rs61141838^1,2	C,	--	145825832(+)	`AGTATT/GTAAGA`	2	--	us2k¹		3		WA NA	240
rs115171283^1,2	F,	--	145825907(+)	`CCTTGG/AGCAAG`	2	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for TCERG1 (145826873 - 145891524 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TCERG1
2 CNVs: 93277 93276

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TCERG1 for disorders           About GeneDecksing

OMIM gene information: 605409    OMIM disorders: --

9 diseases for TCERG1:    About MalaCards

legg-calve-perthes disease spinocerebellar ataxia fanconi's anemia huntington's disease

anemia ataxia immunodeficiency malaria

neuronitis

2 Novoseek disease relationships for TCERG1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
huntington disease	54.1	3	17060612 (1), 12821179 (1), 17018562 (1)
immunodeficiency	21.5	3	15485897 (1), 9315662 (1), 10578054 (1)

Human Genome Epidemiology (HuGE) Navigator: TCERG1 (1 document)

Export disorders for TCERG1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TCERG1 gene, integrated from 9 sources (see all 51):
(articles sorted by number of sources associating them with TCERG1)

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CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription. (PubMed id 9315662)^{1, 2, 3, 9} Sune C....Garcia-Blanco M.A. (1997)
Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II. (PubMed id 10908677)^{1, 2, 9} Carty S.M....Greenleaf A.L. (2000)
The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis. (PubMed id 11172033)^{1, 2, 9} Holbert S....Neri C. (2001)
FF domains of CA150 bind transcription and splicing factors through multiple weak interactions. (PubMed id 15485897)^{1, 2, 9} Smith M.J.... Pawson T. (2004)
The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. (PubMed id 11604498)^{1, 2, 9} Goldstrohm A.C....Garcia-Blanco M.A. (2001)
Expression analysis and mapping of the mouse and huma n transcriptional regulator CA150. (PubMed id 11003711)^{1, 3} Bohne J....Garcia-Blanco M.A. (2000)
Differential effects of sumoylation on transcription and alternative splicing by transcription elongation regulator 1 (TCERG1). (PubMed id 20215116)^{1, 9} SA!nchez-Alvarez M....SuA+Ac C. (2010)
Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner. (PubMed id 10373521)^{1, 9} Sune C. and Garcia-Blanco M.A. (1999)
Human transcription elongation factor CA150 localizes to splicing factor-rich nuclear speckles and assembles transcription and splicing components into complexes through its amino and carboxyl regions. (PubMed id 16782886)^{1, 9} Sanchez-Alvarez M....Sune C. (2006)
Replication of twelve association studies for Huntington's disease residual age of onset in large Venezuelan kindreds. (PubMed id 17018562)^{1, 9} Andresen J.M....Wexler N.S. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10915	HGNC: 15630	AceView: TCERG1	Ensembl:ENSG00000113649	euGenes: HUgn10915
ECgene: TCERG1	Kegg: 10915	H-InvDB: TCERG1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TCERG1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TCERG1 gene
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Patent Information for TCERG1 gene:
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transcription elongation regulator 1

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transcription elongation regulator 1

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