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Aliases for TCERG1 Gene

Aliases for TCERG1 Gene

  • Transcription Elongation Regulator 1 2 3
  • TATA Box-Binding Protein-Associated Factor 2S 2 3 4
  • Transcription Factor CA150 2 3 4
  • TAF2S 3 4 6
  • CA150 3 4 6
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, S, 150kD 2 3
  • Co-Activator Of 150 KDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor 2
  • RNA Polymerase II 2
  • 150kD 2
  • Urn1 3
  • S 2

External Ids for TCERG1 Gene

Previous HGNC Symbols for TCERG1 Gene

  • TAF2S

Previous GeneCards Identifiers for TCERG1 Gene

  • GC05P145795
  • GC05P145855
  • GC05P145807
  • GC05P141093

Summaries for TCERG1 Gene

Entrez Gene Summary for TCERG1 Gene

  • This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCERG1 Gene

TCERG1 (Transcription Elongation Regulator 1) is a Protein Coding gene. Among its related pathways are Spliceosome. GO annotations related to this gene include transcription coactivator activity and RNA polymerase II transcription corepressor activity. An important paralog of this gene is PRPF40A.

UniProtKB/Swiss-Prot for TCERG1 Gene

  • Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.

Gene Wiki entry for TCERG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCERG1 Gene

Genomics for TCERG1 Gene

Regulatory Elements for TCERG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TCERG1 Gene

Start:
146,447,310 bp from pter
End:
146,511,961 bp from pter
Size:
64,652 bases
Orientation:
Plus strand

Genomic View for TCERG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCERG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCERG1 Gene

Proteins for TCERG1 Gene

  • Protein details for TCERG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14776-TCRG1_HUMAN
    Recommended name:
    Transcription elongation regulator 1
    Protein Accession:
    O14776
    Secondary Accessions:
    • Q2NKN2
    • Q59EA1

    Protein attributes for TCERG1 Gene

    Size:
    1098 amino acids
    Molecular mass:
    123901 Da
    Quaternary structure:
    • Binds formin (By similarity). Interacts (via the second WW domain) with TREX1 (via proline-rich region) (By similarity). Binds RNA polymerase II, HD and SF1.
    SequenceCaution:
    • Sequence=BAD93147.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TCERG1 Gene

    Alternative splice isoforms for TCERG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCERG1 Gene

Proteomics data for TCERG1 Gene at MOPED

Post-translational modifications for TCERG1 Gene

  • Ubiquitination at Lys944
  • Modification sites at PhosphoSitePlus

Other Protein References for TCERG1 Gene

No data available for DME Specific Peptides for TCERG1 Gene

Domains for TCERG1 Gene

Protein Domains for TCERG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCERG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14776

UniProtKB/Swiss-Prot:

TCRG1_HUMAN :
  • O14776
Domain:
  • The FF domains bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II, probably mediate interaction with HTATSF1 and preferentially bind peptides with the consensus sequence [DE](2-5)-[FWY]-[DE](2-5)
  • The WW domains bind Pro-rich domains
  • Contains 6 FF domains.
  • Contains 3 WW domains.
genes like me logo Genes that share domains with TCERG1: view

No data available for Gene Families for TCERG1 Gene

Function for TCERG1 Gene

Molecular function for TCERG1 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.
UniProtKB/Swiss-Prot Induction: Up-regulated in brain tissue from patients with Huntington disease.

Gene Ontology (GO) - Molecular Function for TCERG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001103 RNA polymerase II repressing transcription factor binding IPI 20956529
GO:0001106 RNA polymerase II transcription corepressor activity IDA 20956529
GO:0003713 transcription coactivator activity TAS 9315662
GO:0005515 protein binding IPI 15383276
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TCERG1: view

Phenotypes for TCERG1 Gene

GenomeRNAi human phenotypes for TCERG1:
genes like me logo Genes that share phenotypes with TCERG1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TCERG1 Gene

Localization for TCERG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCERG1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCERG1 Gene COMPARTMENTS Subcellular localization image for TCERG1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TCERG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with TCERG1: view

Pathways for TCERG1 Gene

SuperPathways for TCERG1 Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with TCERG1: view

Pathways by source for TCERG1 Gene

1 KEGG pathway for TCERG1 Gene

Gene Ontology (GO) - Biological Process for TCERG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 20956529
GO:0006366 transcription from RNA polymerase II promoter TAS 9315662
genes like me logo Genes that share ontologies with TCERG1: view

Compounds for TCERG1 Gene

(1) Novoseek inferred chemical compound relationships for TCERG1 Gene

Compound -log(P) Hits PubMed IDs
glutamine 21 2
genes like me logo Genes that share compounds with TCERG1: view

Transcripts for TCERG1 Gene

Unigene Clusters for TCERG1 Gene

Transcription elongation regulator 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCERG1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TCERG1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCERG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a ·
SP1: -
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7: - -
SP8: - -
SP9:
SP10:
SP11:
SP12: - -
SP13: - - - -
SP14:
SP15:
SP16:

ExUns: 15b · 15c · 15d ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28a · 28b
SP1:
SP2: - - -
SP3: - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TCERG1 Gene

GeneLoc Exon Structure for
TCERG1
ECgene alternative splicing isoforms for
TCERG1

Expression for TCERG1 Gene

mRNA expression in normal human tissues for TCERG1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCERG1 Gene

SOURCE GeneReport for Unigene cluster for TCERG1 Gene Hs.443465

mRNA Expression by UniProt/SwissProt for TCERG1 Gene

O14776-TCRG1_HUMAN
Tissue specificity: Detected in brain neurons.
genes like me logo Genes that share expressions with TCERG1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TCERG1 Gene

Orthologs for TCERG1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TCERG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCERG1 35
  • 99.84 (n)
  • 100 (a)
TCERG1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCERG1 35
  • 95.33 (n)
  • 98.93 (a)
TCERG1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCERG1 35
  • 95.8 (n)
  • 99.17 (a)
TCERG1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcerg1 35
  • 91.91 (n)
  • 97.85 (a)
Tcerg1 16
Tcerg1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCERG1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCERG1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcerg1 35
  • 92.87 (n)
  • 97.98 (a)
chicken
(Gallus gallus)
Aves TCERG1 35
  • 82.41 (n)
  • 95.1 (a)
TCERG1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.5868 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3267 35
tcerg1 35
  • 75.18 (n)
  • 82.27 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10117 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-177d9.1 36
  • 20 (a)
ManyToMany
tcerg1 35
tcerg1a 35
  • 67.92 (n)
  • 72.42 (a)
tcerg1a 36
  • 65 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tcer-1 35
  • 51.72 (n)
  • 40.78 (a)
tcer-1 36
  • 34 (a)
ManyToMany
ZK1127.6 36
  • 36 (a)
ManyToMany
ZK1127.9c 37
  • 36 (a)
ZK1127.6 37
  • 37 (a)
ZK1127.9a 37
  • 36 (a)
ZK1127.9b 37
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP40 36
  • 20 (a)
OneToMany
Species with no ortholog for TCERG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCERG1 Gene

ENSEMBL:
Gene Tree for TCERG1 (if available)
TreeFam:
Gene Tree for TCERG1 (if available)

Paralogs for TCERG1 Gene

Paralogs for TCERG1 Gene

Selected SIMAP similar genes for TCERG1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TCERG1 Gene

genes like me logo Genes that share paralogs with TCERG1: view

Variants for TCERG1 Gene

Sequence variations from dbSNP and Humsavar for TCERG1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs962591 -- 146,499,750(+) TTTAT(A/C)TTTGC intron-variant
rs998051 -- 146,495,696(+) GAGAT(G/T)AACTG intron-variant
rs1025478 -- 146,480,622(-) CCGCC(A/G)TAACA intron-variant
rs1025479 -- 146,462,922(-) CTGTG(A/T)ATGCC intron-variant
rs1056894 -- 146,480,584(+) TAGCT(C/T)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCERG1 Gene

Variant ID Type Subtype PubMed ID
esv2730879 CNV Deletion 23290073
esv2677262 CNV Deletion 23128226

Relevant External Links for TCERG1 Gene

HapMap Linkage Disequilibrium report
TCERG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCERG1 Gene

Disorders for TCERG1 Gene

(2) Novoseek inferred disease relationships for TCERG1 Gene

Disease -log(P) Hits PubMed IDs
huntington disease 54.1 3
immunodeficiency 21.5 3

Relevant External Links for TCERG1

Genetic Association Database (GAD)
TCERG1
Human Genome Epidemiology (HuGE) Navigator
TCERG1
genes like me logo Genes that share disorders with TCERG1: view

No data available for UniProtKB/Swiss-Prot for TCERG1 Gene

Publications for TCERG1 Gene

  1. CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription. (PMID: 9315662) Sune C. … Garcia-Blanco M.A. (Mol. Cell. Biol. 1997) 2 3 4 23
  2. Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II. (PMID: 10908677) Carty S.M. … Greenleaf A.L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23
  3. FF domains of CA150 bind transcription and splicing factors through multiple weak interactions. (PMID: 15485897) Smith M.J. … Pawson T. (Mol. Cell. Biol. 2004) 3 4 23
  4. The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis. (PMID: 11172033) Holbert S. … Neri C. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23
  5. The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. (PMID: 11604498) Goldstrohm A.C. … Garcia-Blanco M.A. (Mol. Cell. Biol. 2001) 3 4 23

Products for TCERG1 Gene

  • antibodies-online peptides for TCERG1
  • antibodies-online antibodies for TCERG1
  • antibodies-online kits for TCERG1

Sources for TCERG1 Gene

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