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TCERG1 Gene

protein-coding   GIFtS: 59
GCID: GC05P145807

Transcription Elongation Regulator 1

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2S)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Elongation Regulator 11 2     Co-Activator Of 150 KDa1 2
TAF2S1 2 3 5     150kD1
TATA Box-Binding Protein-Associated Factor 2S1 2 3     S1
Transcription Factor CA1501 2 3     RNA Polymerase II1
CA1502 3 5     TATA Box Binding Protein (TBP)-Associated Factor1
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, S,
150kD1 2
     Urn12

External Ids:    HGNC: 156301   Entrez Gene: 109152   Ensembl: ENSG000001136497   OMIM: 6054095   UniProtKB: O147763   

Export aliases for TCERG1 gene to outside databases

Previous GC identifers: GC05P145795 GC05P146408 GC05P145855 GC05P141093


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCERG1 Gene:
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded
protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains,
and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts
variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for TCERG1 Gene:
TCERG1 (transcription elongation regulator 1) is a protein-coding gene. Diseases associated with TCERG1 include legg-calve-perthes disease, and huntington's disease. GO annotations related to this gene include transcription coactivator activity and RNA polymerase II transcription corepressor activity. An important paralog of this gene is PRPF40B.

UniProtKB/Swiss-Prot: TCRG1_HUMAN, O14776
Function: Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target
promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent
activation of the human immunodeficiency virus type 1 (HIV-1) promoter

Gene Wiki entry for TCERG1 (Transcription elongation regulator 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCERG1 gene promoter:
         RFX1   p53   Meis-1a   Meis-1b   Meis-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCERG1 promoter sequence
   Search Chromatin IP Primers for TCERG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCERG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q31

TCERG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCERG1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P145807:  view genomic region     (about GC identifiers)

Start:
145,826,873 bp from pter      End:
145,891,524 bp from pter
Size:
64,652 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TCRG1_HUMAN, O14776 (See protein sequence)
Recommended Name: Transcription elongation regulator 1  
Size: 1098 amino acids; 123901 Da
Subunit: Binds formin (By similarity). Interacts (via the second WW domain) with TREX1 (via proline-rich region)
(By similarity). Binds RNA polymerase II, HD and SF1
Sequence caution: Sequence=BAD93147.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for TCERG1 (see all 10):
2DK7 (3D)        2DOD (3D)        2DOE (3D)        2DOF (3D)        2E71 (3D)        2KIQ (3D)    
Secondary accessions: Q2NKN2 Q59EA1
Alternative splicing: 2 isoforms:  O14776-1   O14776-2   

Explore the universe of human proteins at neXtProt for TCERG1: NX_O14776

Explore proteomics data for TCERG1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys944
  • Modification sites at PhosphoSitePlus

  • See TCERG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035095.1  NP_006697.2  

    ENSEMBL proteins: 
     ENSP00000296702   ENSP00000377943   ENSP00000450414  

    TCERG1 Human Recombinant Protein Products:

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    Novus Biologicals TCERG1 Lysate
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    Cloud-Clone Corp. Proteins for TCERG1

    TCERG1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for TCERG1

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    Cloud-Clone Corp. CLIAs for TCERG1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002713 FF_domain
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry O14776

    ProtoNet protein and cluster: O14776

    UniProtKB/Swiss-Prot: TCRG1_HUMAN, O14776
    Domain: The FF domains bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II, probably
    mediate interaction with HTATSF1 and preferentially bind peptides with the consensus sequence
    [DE](2-5)-[FWY]-[DE](2-5)
    Domain: The WW domains bind Pro-rich domains
    Similarity: Contains 6 FF domains
    Similarity: Contains 3 WW domains


    TCERG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCRG1_HUMAN, O14776
    Function: Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target
    promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent
    activation of the human immunodeficiency virus type 1 (HIV-1) promoter
    Induction: Up-regulated in brain tissue from patients with Huntington disease

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001103RNA polymerase II repressing transcription factor binding IPI--
    GO:0001106RNA polymerase II transcription corepressor activity IDA--
    GO:0003713transcription coactivator activity TAS9315662
    GO:0005515protein binding IPI15383276
    GO:0044822poly(A) RNA binding IDA--
         
    TCERG1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TCERG1:
     Decreased Hepatitis C virus re  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCERG1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCERG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TCERG1

    miRNA
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    miRTarBase miRNAs that target TCERG1:
    hsa-mir-222-3p (MIRT046720), hsa-mir-877-3p (MIRT037086), hsa-mir-328-3p (MIRT043747), hsa-mir-98-5p (MIRT027828), hsa-let-7a-5p (MIRT052589), hsa-mir-769-5p (MIRT039212), hsa-mir-615-3p (MIRT040393)

    Block miRNA regulation of human, mouse, rat TCERG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TCERG1 (see all 17):
    hsa-miR-607 hsa-miR-181c hsa-miR-200a hsa-miR-141 hsa-miR-548g hsa-miR-3143 hsa-miR-330-3p hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidTCERG1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TCERG1
    Predesigned siRNA for gene silencing in human, mouse, rat TCERG1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): TCERG1 (NM_006706)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCERG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCERG1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCERG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCRG1_HUMAN, O14776: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TCERG1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TCERG1 About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for TCERG1):
        Spliceosome


    TCERG1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCERG1
    Interactions:

        GeneGlobe Interaction Network for TCERG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TCERG1 (O147761, 2, 3 ENSP000002967024) via UniProtKB, MINT, STRING, and/or I2D (see all 135)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    ENSG00000231555P081073I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0006366transcription from RNA polymerase II promoter TAS9315662

    TCERG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCERG1 (TCRG1)

    1 Novoseek inferred chemical compound relationship for TCERG1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamine 21 2 9315662 (1), 11172033 (1)



    TCERG1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TCERG1 gene (2 alternative transcripts): 
    NM_001040006.1  NM_006706.3  

    Unigene Cluster for TCERG1:

    Transcription elongation regulator 1
    Hs.443465  [show with all ESTs]
    Unigene Representative Sequence: NM_006706
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507175(uc011dbt.2) ENST00000296702(uc003lob.3 uc003loc.3)
    ENST00000394421 ENST00000549332 ENST00000513298 ENST00000510724 ENST00000509810
    ENST00000515203 ENST00000506524 ENST00000505285 ENST00000504116 ENST00000509787
    ENST00000514567 ENST00000514719 ENST00000503741 ENST00000511077
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat TCERG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TCERG1 (see all 17):
    hsa-miR-607 hsa-miR-181c hsa-miR-200a hsa-miR-141 hsa-miR-548g hsa-miR-3143 hsa-miR-330-3p hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidTCERG1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TCERG1
    Predesigned siRNA for gene silencing in human, mouse, rat TCERG1
    Clone
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    OriGene clones in human, mouse for TCERG1 (see all 13)
    OriGene ORF clones in mouse, rat for TCERG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TCERG1 (NM_006706)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCERG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCERG1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TCERG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TCERG1
      QuantiTect SYBR Green Assays in human, mouse, rat TCERG1
      QuantiFast Probe-based Assays in human, mouse, rat TCERG1

    Additional mRNA sequence: 

    AB209910.1 AF017789.1 AK126455.1 AK304319.1 BC006109.1 BC014151.2 BC015864.1 BC062351.1 
    BC111727.1 

    19 DOTS entries:

    DT.100820288  DT.318176  DT.454594  DT.100802883  DT.439166  DT.92432274  DT.100024950  DT.97861907 
    DT.100024951  DT.91741504  DT.92432279  DT.95331046  DT.75133302  DT.91664930  DT.91957713  DT.95077019 
    DT.95210011  DT.91731885  DT.100019445 

    Selected AceView cDNA sequences (see all 308):

    BE276879 BX646813 BG943061 AI479634 AI460364 CB119403 AA670161 AA248385 
    CN479299 AW583339 CB162536 AA151109 AI218274 BM459699 BC062351 AA737490 
    BM800080 AU125627 BM798311 NM_006706 AA971533 BM826675 BE047344 BE550061 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TCERG1 (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a ·
    SP1:                                                                                                                                -                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                -                           
    SP5:              -                                                                                                                                             

    ExUns: 15b · 15c · 15d ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28a · 28b
    SP1:                                                                                                                              
    SP2:              -     -                                   -                                                                     
    SP3:                                                                                            -                 -               
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for TCERG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCERG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGCCAGAA
    TCERG1 Expression
    About this image

    TCERG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCERG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.443465

    UniProtKB/Swiss-Prot: TCRG1_HUMAN, O14776
    Tissue specificity: Detected in brain neurons

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    QuantiFast Probe-based Assays in human, mouse, rat TCERG1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCERG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TCERG1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcerg11 , 5 transcription elongation regulator 1 (CA150)1, 5 91.91(n)1
    97.85(a)1
      18 (22.66 cM)5
    560701  NM_001039474.11  NP_001034563.11 
     425115105 
    chicken
    (Gallus gallus)
    Aves TCERG11 transcription elongation regulator 1 82.41(n)
    95.1(a)
      416349  XM_004945050.1  XP_004945107.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    84(a)
    many ↔ many
    GL343234.1(432182-479430)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.58682 Xenopus laevis, Similar to transcription elongation more 80.75(n)    BC046714.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tcerg12 transcription elongation regulator 1 (CA150) 74.13(n)   323071  BC056813.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK1127.63
    tcer-11
    tcer-11 37(a)
    (best of 4)3
    51.72(n)1
    40.78(a)1
      II(7042816-7044303)3
    1741501  NM_063042.31  NP_495443.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP406
    U1 snRNP protein involved in splicing, interacts w...
    20(a)
    1 → many
    XI(418310-420061) YKL012W


    ENSEMBL Gene Tree for TCERG1 (if available)
    TreeFam Gene Tree for TCERG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCERG1 gene
    PRPF40B2  PRPF40A2  TCERG1L2  
    1 SIMAP similar gene for TCERG1 using alignment to 2 protein entries:     TCRG1_HUMAN (see all proteins):
    TCERG1L

    TCERG1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for TCERG1
    PGOHUM00000248743 PGOHUM00000243236 PGOHUM00000241966


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCERG1 (see all 1305)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs24002171,2
    C--145824951(+) ctggaC/Tgtggt 2 -- us2k111Minor allele frequency- T:0.02NA WA CSA EA 372
    rs1813696691,2
    --145825346(+) CAGGCA/GGCCTT 2 -- us2k10--------
    rs1474305501,2
    C--145825393(+) TGTAC-/AGTT  
            
    AGTTA
    2 -- us2k10--------
    rs3740855051,2
    C--145825394(+) TTGTA-/AGT   
      T
    /GTTA
    GTTAT
    2 -- us2k10--------
    rs1862870241,2
    --145825403(+) ATACCA/CTGTTT 2 -- us2k10--------
    rs68627711,2
    C,F,H--145825440(+) tctgtC/Tgccca 2 -- us2k16Minor allele frequency- T:0.18NA WA CSA 11
    rs1497551251,2
    --145825630(+) GACCTC/TGTGAT 2 -- us2k10--------
    rs20334741,2
    C,F,A,H--145825685(+) ccaccT/Gcgccc 2 -- us2k115Minor allele frequency- G:0.19EA NS NA WA CSA 797
    rs1921398361,2
    --145825809(+) TGGATC/TCAATT 2 -- us2k10--------
    rs611418381,2
    C,F--145825832(+) AGTATT/GTAAGA 2 -- us2k13Minor allele frequency- G:0.03WA NA 240

    HapMap Linkage Disequilibrium report for TCERG1 (145826873 - 145891524 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TCERG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677262CNV Deletion23128226
    esv2730879CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCERG1
    DNA2.0 Custom Variant and Variant Library Synthesis for TCERG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605409    OMIM disorders: --

    8 diseases for TCERG1:    
    About MalaCards
    legg-calve-perthes disease    huntington's disease    spinocerebellar ataxia    fanconi's anemia
    ataxia    hiv-1    malaria    neuronitis


    TCERG1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TCERG1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    huntington disease 54.1 3 17060612 (1), 12821179 (1), 17018562 (1)
    immunodeficiency 21.5 3 15485897 (1), 9315662 (1), 10578054 (1)

    Genetic Association Database (GAD): TCERG1
    Human Genome Epidemiology (HuGE) Navigator: TCERG1 (1 document)

    Export disorders for TCERG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCERG1 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with TCERG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription. (PubMed id 9315662)1, 2, 3, 9 Sune C....Garcia-Blanco M.A. (Mol. Cell. Biol. 1997)
    2. Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II. (PubMed id 10908677)1, 2, 9 Carty S.M....Greenleaf A.L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    3. The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis. (PubMed id 11172033)1, 2, 9 Holbert S....Neri C. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    4. FF domains of CA150 bind transcription and splicing factors through multiple weak interactions. (PubMed id 15485897)1, 2, 9 Smith M.J.... Pawson T. (Mol. Cell. Biol. 2004)
    5. The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. (PubMed id 11604498)1, 2, 9 Goldstrohm A.C....Garcia-Blanco M.A. (Mol. Cell. Biol. 2001)
    6. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PubMed id 19845895)1, 4 Koskinen L.L....Saavalainen P. (Tissue Antigens 2009)
    7. Expression analysis and mapping of the mouse and human transcriptional regulator CA150. (PubMed id 11003711)1, 3 Bohne J....Garcia-Blanco M.A. (Mamm. Genome 2000)
    8. Differential effects of sumoylation on transcription and alternative splicing by transcription elongation regulator 1 (TCERG1). (PubMed id 20215116)1, 9 SA!nchez-Alvarez M....SuA+Ac C. (J. Biol. Chem. 2010)
    9. Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner. (PubMed id 10373521)1, 9 SuA+Ac C. and Garcia-Blanco M.A. (Mol. Cell. Biol. 1999)
    10. Human transcription elongation factor CA150 localizes to splicing factor-rich nuclear speckles and assembles transcription and splicing components into complexes through its amino and carboxyl regions. (PubMed id 16782886)1, 9 SA!nchez-Alvarez M....SuA+Ac C. (Mol. Cell. Biol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10915 HGNC: 15630 AceView: TCERG1 Ensembl:ENSG00000113649 euGenes: HUgn10915
    ECgene: TCERG1 Kegg: 10915 H-InvDB: TCERG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TCERG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCERG1 gene:
    Search GeneIP for patents involving TCERG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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