TCEB3CL2 Gene
protein-coding GIFtS: 22
GCID: GC18M044543
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transcription elongation factor B polypeptide 3C-like 2
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Aliases
for TCEB3CL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transcription Elongation Factor B Polypeptide 3C-Like 21 2 | | RNA Polymerase II Transcription Factor SIII Subunit A3-Like-22 | | Transcription Elongation Factor B Polypeptide 3C-Like-22 3 | | EloA3-Like-21 | | EloA3-Like-21 | | Elongin-A3-Like-21 | | Elongin-A3-Like-21 | | |
Export aliases for TCEB3CL2 gene to outside databasesPrevious GC identifers: GC18M042797 GC18U900519 |
Summaries
for TCEB3CL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: EA3L2_HUMAN, A6NLF2Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymeraseII transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but itstranscription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C(elongin BC complex) (By similarity)
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Genomic Views
for TCEB3CL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TCEB3CL2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCEB3CL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEB3CL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q21.1 Ensembl cytogenetic band: 18q21.1 HGNC cytogenetic band: 18q21.1TCEB3CL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M044543: view genomic region
(about GC identifiers)
Start:
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44,542,731 bp from pter |
End:
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44,544,607 bp from pter |
Size:
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1,877 bases |
Orientation:
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minus strand |
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Proteins
for TCEB3CL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EA3L2_HUMAN, A6NLF2 (See
protein sequence)Recommended Name: RNA polymerase II transcription factor SIII subunit A3-like-2 Size: 546 amino acids; 59772 Da
Subunit: Heterotrimer of an A (A1, A2 or A3), B and C subunit (By similarity)
Subcellular location: Nucleus (By similarity)Explore the universe of human proteins at neXtProt for TCEB3CL2: NX_A6NLF2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NLF2
TCEB3CL2 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001229836.1
ENSEMBL proteins: ENSP00000468046
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TCEB3CL2 for ontologies About GeneDecksing
TCEB3CL2 Antibody Products:
Assay Products for TCEB3CL2: |
Protein
Domains /
Families
for TCEB3CL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCEB3CL2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NLF2ProtoNet protein and cluster: A6NLF2 UniProtKB/Swiss-Prot: EA3L2_HUMAN, A6NLF2Domain: The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]Similarity: Contains 1 TFIIS N-terminal domain |
Function
for TCEB3CL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: EA3L2_HUMAN, A6NLF2Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymeraseII transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but itstranscription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C(elongin BC complex) (By similarity)
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0003677 | DNA binding |
IEA | -- |
TCEB3CL2 for ontologies About GeneDecksing
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Pathways & Interactions
for TCEB3CL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCEB3CL2
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
TCEB3CL2 for ontologies About GeneDecksing
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Drugs & Compounds
for TCEB3CL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TCEB3CL2
Search CenterWatch for drugs/clinical trials and news about TCEB3CL2 / EA3L2 
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Transcripts
for TCEB3CL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCEB3CL2 gene: NM_001242907.1 Unigene Cluster for TCEB3CL2: Transcription elongation factor B polypeptide 3C-like 2 Hs.729823 [show with all ESTs]Unigene Representative Sequence: NM_0012429071 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000591973
1 DOTS entry: DT.99999629
GeneLoc Exon Structure
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Expression
for TCEB3CL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SOURCE GeneReport for Unigene cluster: Hs.729823
SABiosciences Custom PCR Arrays for TCEB3CL2
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TCEB3CL2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCEB3CL2 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEB3CL2 |
Orthologs
for TCEB3CL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for TCEB3CL2 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TCEB36 |
elongin A |
28(a) |
1 → many |
23(5842349-5853476) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
28(a) |
1 → many |
GL343498.1(149248-165168) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:555736 |
zgc:55573 |
29(a) |
1 → many |
19(45359678-45381419) |
fruit fly
(Drosophila melanogaster) |
Insecta |
EloA6 |
Elongin A |
19(a) |
1 → many |
3R(19077266-19080793) |
worm
(Caenorhabditis elegans) |
Secernentea |
R03D7.46 |
Transcription elongation factor B polypeptide 3 |
20(a) |
1 → many |
II(10943331-10945600) |
ENSEMBL Gene Tree for TCEB3CL2 (if available)
TreeFam Gene Tree for TCEB3CL2 (if available) |
Paralogs
for TCEB3CL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TCEB3CL2 gene
- TCEB3CL1 2 TCEB3C1 2 TCEB32 TCEB3B2
3 SIMAP similar genes for TCEB3CL2 using alignment to 1 protein entry: EA3L2_HUMAN:TCEB3C TCEB3CL TCEB3B
TCEB3CL2 for paralogs About GeneDecksing
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Genomic Variants
for TCEB3CL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for TCEB3CL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TCEB3CL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed article for TCEB3CL2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TCEB3CL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)1, 2 Nusbaum C.... Lander E.S. (2005)
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External Searches for TCEB3CL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TCEB3CL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing TCEB3CL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCEB3CL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
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About This Section
| Patent Information for TCEB3CL2 gene:
Search GeneIP for patents involving TCEB3CL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCEB3CL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCEB3CL2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCEB3CL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEB3CL2 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCEB3CL2 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEB3CL2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCEB3CL2 |
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 | | | TCEB3CL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for TCEB3CL2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TCEB3CL2 |
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