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TCEB3CL2 Gene

protein-coding   GIFtS: 20
GCID: GC18M044543

Transcription Elongation Factor B Polypeptide 3C-Like 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Elongation Factor B Polypeptide 3C-Like 21 2     RNA Polymerase II Transcription Factor SIII Subunit A3-Like-22
Transcription Elongation Factor B Polypeptide 3C-Like-22 3     EloA3-like-23
eloA3-like-22     Elongin-A3-like-23
elongin-A3-like-22     

External Ids:    HGNC: 335111   Entrez Gene: 1005068882   Ensembl: ENSG000002669967   UniProtKB: A6NLF23   

Export aliases for TCEB3CL2 gene to outside databases

Previous GC identifers: GC18M042797 GC18U900519


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TCEB3CL2 Gene:
TCEB3CL2 (transcription elongation factor B polypeptide 3C-like 2) is a protein-coding gene. An important paralog of this gene is TCEB3.

UniProtKB/Swiss-Prot: EA3L2_HUMAN, A6NLF2
Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA
polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally
active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory
subunits B and C (elongin BC complex) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for TCEB3CL2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCEB3CL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21.1

TCEB3CL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEB3CL2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M044543:  view genomic region     (about GC identifiers)

Start:
44,542,731 bp from pter      End:
44,544,607 bp from pter
Size:
1,877 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EA3L2_HUMAN, A6NLF2 (See protein sequence)
Recommended Name: RNA polymerase II transcription factor SIII subunit A3-like-2  
Size: 546 amino acids; 59772 Da
Subunit: Heterotrimer of an A (A1, A2 or A3), B and C subunit (By similarity)

Explore the universe of human proteins at neXtProt for TCEB3CL2: NX_A6NLF2

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_001229836.1  
    ENSEMBL proteins: 
     ENSP00000468046  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR010684 RNA_pol_II_trans_fac_SIII_A
     IPR017923 TFIIS_N

    Graphical View of Domain Structure for InterPro Entry A6NLF2

    ProtoNet protein and cluster: A6NLF2

    UniProtKB/Swiss-Prot: EA3L2_HUMAN, A6NLF2
    Domain: The elongin BC complex binding domain is also known as BC-box with the consensus
    [APST]-L-x(3)-C-x(3)-[AILV]
    Similarity: Contains 1 TFIIS N-terminal domain


    Find genes that share domains with TCEB3CL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EA3L2_HUMAN, A6NLF2
    Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA
    polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally
    active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory
    subunits B and C (elongin BC complex) (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    Find genes that share ontologies with TCEB3CL2           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EA3L2_HUMAN, A6NLF2: Nucleus (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TCEB3CL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCEB3CL2
    Interactions:

        Search GeneGlobe Interaction Network for TCEB3CL2

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with TCEB3CL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCEB3CL2 (EA3L2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TCEB3CL2 gene: 
    NM_001242907.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000591973
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    TCEB3CL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
        Custom PCR Arrays for TCEB3CL2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEB3CL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TCEB3CL2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    Uncharacterized protein
    29(a)
    22(a)
    many ↔ many
    many ↔ many
    4(360072146-360091182)
    X(30374740-30377328)
    chicken
    (Gallus gallus)
    Aves TCEB36
    Gallus gallus transcription elongation factor B (S...
    24(a)
    1 → many
    23(5518731-5536543)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    27(a)
    1 → many
    GL343498.1(149248-165168)
    zebrafish
    (Danio rerio)
    Actinopterygii tceb36
    transcription elongation factor B (SIII), polypept...
    27(a)
    1 → many
    19(45359678-45381419) ENSDARG00000011637
    fruit fly
    (Drosophila melanogaster)
    Insecta EloA6
    Elongin A
    21(a)
    1 → many
    3R(19077266-19080793)
    worm
    (Caenorhabditis elegans)
    Secernentea R03D7.46
    Protein R03D7.4 (R03D7.4) mRNA, complete cds
    19(a)
    1 → many
    II(10943391-10945660) WBGene00010990


    ENSEMBL Gene Tree for TCEB3CL2 (if available)
    TreeFam Gene Tree for TCEB3CL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCEB3CL2 gene
    TCEB3CL1 2  TCEB3C1 2  LOC101930171  TCEB32  TCEB3B2  
    3 SIMAP similar genes for TCEB3CL2 using alignment to 1 protein entry:     EA3L2_HUMAN:
    TCEB3C    TCEB3CL    TCEB3B

    Find genes that share paralogs with TCEB3CL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    3 SNPs for TCEB3CL2    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22612911,2,4
    ----see VAR_0443782 mis40--------
    rs1438132541,2
    ----44545544(+) TCCCC-/GCCCC 
            
    CCCCC
    1 -- us2k10--------
    rs1494433581,2
    ----44545541(+) GCATC-/CCCG  
            
    CCCCC
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TCEB3CL2 (44542731 - 44544607 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TCEB3CL2: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TCEB3CL2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed article for TCEB3CL2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TCEB3CL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)1, 2 Nusbaum C.... Lander E.S. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100506888 HGNC: 33511 Ensembl:ENSG00000266996 euGenes: HUgn100506888 ECgene: TCEB3CL2
    H-InvDB: TCEB3CL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCEB3CL2 gene:
    Search GeneIP for patents involving TCEB3CL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse SwitchGear Promoter luciferase reporter plasmids for TCEB3CL2
     Search ThermoFisher Antibodies for TCEB3CL2
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TCEB3CL2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCEB3CL2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TCEB3CL2
     Search LSBio for Antibodies for TCEB3CL2
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     Browse compounds at ApexBio
     Search Addgene for plasmids for TCEB3CL2
      Search eBioscience for proteins for TCEB3CL2
      Search eBioscience for elisas for TCEB3CL2
      eBioscience FlowRNA Probe Sets
           
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