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Aliases for TCEB3CL2 Gene

Aliases for TCEB3CL2 Gene

  • Transcription Elongation Factor B Polypeptide 3C-Like 2 2 3
  • Transcription Elongation Factor B Polypeptide 3C-Like-2 3 4
  • Elongin-A3-Like-2 3 4
  • EloA3-Like-2 3 4

External Ids for TCEB3CL2 Gene

Previous GeneCards Identifiers for TCEB3CL2 Gene

  • GC18M042797
  • GC18U900519
  • GC18M044543

Summaries for TCEB3CL2 Gene

GeneCards Summary for TCEB3CL2 Gene

TCEB3CL2 (Transcription Elongation Factor B Polypeptide 3C-Like 2) is a Protein Coding gene. An important paralog of this gene is TCEB3CL.

UniProtKB/Swiss-Prot for TCEB3CL2 Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEB3CL2 Gene

Genomics for TCEB3CL2 Gene

Genomic Location for TCEB3CL2 Gene

Chromosome:
18
Start:
46,962,768 bp from pter
End:
46,964,644 bp from pter
Size:
1,877 bases
Orientation:
Minus strand

Genomic View for TCEB3CL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEB3CL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEB3CL2 Gene

No data available for Regulatory Elements for TCEB3CL2 Gene

Proteins for TCEB3CL2 Gene

  • Protein details for TCEB3CL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLF2-EA3L2_HUMAN
    Recommended name:
    RNA polymerase II transcription factor SIII subunit A3-like-2
    Protein Accession:
    A6NLF2

    Protein attributes for TCEB3CL2 Gene

    Size:
    546 amino acids
    Molecular mass:
    59772 Da
    Quaternary structure:
    • Heterotrimer of an A (A1, A2 or A3), B and C subunit.

neXtProt entry for TCEB3CL2 Gene

Proteomics data for TCEB3CL2 Gene at MOPED

Post-translational modifications for TCEB3CL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEB3CL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCEB3CL2 Gene

Domains & Families for TCEB3CL2 Gene

Protein Domains for TCEB3CL2 Gene

Suggested Antigen Peptide Sequences for TCEB3CL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NLF2

UniProtKB/Swiss-Prot:

EA3L2_HUMAN :
  • The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]
Domain:
  • The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]
  • Contains 1 TFIIS N-terminal domain.
genes like me logo Genes that share domains with TCEB3CL2: view

No data available for Gene Families for TCEB3CL2 Gene

Function for TCEB3CL2 Gene

Molecular function for TCEB3CL2 Gene

UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity).

Gene Ontology (GO) - Molecular Function for TCEB3CL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TCEB3CL2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCEB3CL2 Gene

Localization for TCEB3CL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEB3CL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEB3CL2 Gene COMPARTMENTS Subcellular localization image for TCEB3CL2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for TCEB3CL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TCEB3CL2: view

Pathways & Interactions for TCEB3CL2 Gene

SuperPathways for TCEB3CL2 Gene

No Data Available

Interacting Proteins for TCEB3CL2 Gene

Gene Ontology (GO) - Biological Process for TCEB3CL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCEB3CL2: view

No data available for Pathways by source and SIGNOR curated interactions for TCEB3CL2 Gene

Drugs & Compounds for TCEB3CL2 Gene

No Compound Related Data Available

Transcripts for TCEB3CL2 Gene

mRNA/cDNA for TCEB3CL2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCEB3CL2 Gene

Transcription elongation factor B polypeptide 3C-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCEB3CL2 Gene

No ASD Table

Relevant External Links for TCEB3CL2 Gene

GeneLoc Exon Structure for
TCEB3CL2
ECgene alternative splicing isoforms for
TCEB3CL2

Expression for TCEB3CL2 Gene

mRNA expression in normal human tissues for TCEB3CL2 Gene

SOURCE GeneReport for Unigene cluster for TCEB3CL2 Gene Hs.729823

genes like me logo Genes that share expression patterns with TCEB3CL2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TCEB3CL2 Gene

Orthologs for TCEB3CL2 Gene

Evolution for TCEB3CL2 Gene

ENSEMBL:
Gene Tree for TCEB3CL2 (if available)
TreeFam:
Gene Tree for TCEB3CL2 (if available)

No data available for Orthologs for TCEB3CL2 Gene

Paralogs for TCEB3CL2 Gene

Paralogs for TCEB3CL2 Gene

(3) SIMAP similar genes for TCEB3CL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCEB3CL2: view

Variants for TCEB3CL2 Gene

Sequence variations from dbSNP and Humsavar for TCEB3CL2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
VAR_044378 -

Variation tolerance for TCEB3CL2 Gene

Gene Damage Index Score: 0.18; 3.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEB3CL2 Gene

HapMap Linkage Disequilibrium report
TCEB3CL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEB3CL2 Gene

Disorders for TCEB3CL2 Gene

Relevant External Links for TCEB3CL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEB3CL2
genes like me logo Genes that share disorders with TCEB3CL2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEB3CL2 Gene

Publications for TCEB3CL2 Gene

  1. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 67

Products for TCEB3CL2 Gene

Sources for TCEB3CL2 Gene

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