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Aliases for TCEB3CL Gene

Aliases for TCEB3CL Gene

  • Transcription Elongation Factor B Subunit 3C Like 2 3
  • Transcription Elongation Factor B Polypeptide 3C-Like 2 3 5
  • Transcription Elongation Factor B Polypeptide 3C-Like-1 3 4
  • Elongin-A3-Like-1 3 4
  • EloA3-Like-1 3 4
  • HsT828 3

External Ids for TCEB3CL Gene

Previous GeneCards Identifiers for TCEB3CL Gene

  • GC00U914143
  • GC18U900196
  • GC18M042805
  • GC18M044548

Summaries for TCEB3CL Gene

GeneCards Summary for TCEB3CL Gene

TCEB3CL (Transcription Elongation Factor B Subunit 3C Like) is a Protein Coding gene. An important paralog of this gene is TCEB3C.

UniProtKB/Swiss-Prot for TCEB3CL Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEB3CL Gene

Genomics for TCEB3CL Gene

Regulatory Elements for TCEB3CL Gene


Promoters for TCEB3CL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCEB3CL on UCSC Golden Path with GeneCards custom track

Genomic Location for TCEB3CL Gene

Chromosome:
18
Start:
46,968,695 bp from pter
End:
47,029,842 bp from pter
Size:
61,148 bases
Orientation:
Minus strand

Genomic View for TCEB3CL Gene

Genes around TCEB3CL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEB3CL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEB3CL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEB3CL Gene

Proteins for TCEB3CL Gene

  • Protein details for TCEB3CL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SY89-EA3L1_HUMAN
    Recommended name:
    RNA polymerase II transcription factor SIII subunit A3-like-1
    Protein Accession:
    Q3SY89
    Secondary Accessions:
    • Q3MI93

    Protein attributes for TCEB3CL Gene

    Size:
    546 amino acids
    Molecular mass:
    59758 Da
    Quaternary structure:
    • Heterotrimer of an A (A1, A2 or A3), B and C subunit.

neXtProt entry for TCEB3CL Gene

Proteomics data for TCEB3CL Gene at MOPED

Post-translational modifications for TCEB3CL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEB3CL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCEB3CL Gene

Domains & Families for TCEB3CL Gene

Protein Domains for TCEB3CL Gene

Suggested Antigen Peptide Sequences for TCEB3CL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3SY89

UniProtKB/Swiss-Prot:

EA3L1_HUMAN :
  • The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
Domain:
  • The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
  • Contains 1 TFIIS N-terminal domain.
genes like me logo Genes that share domains with TCEB3CL: view

No data available for Gene Families for TCEB3CL Gene

Function for TCEB3CL Gene

Molecular function for TCEB3CL Gene

UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity).

Phenotypes for TCEB3CL Gene

genes like me logo Genes that share phenotypes with TCEB3CL: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCEB3CL Gene

Localization for TCEB3CL Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEB3CL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEB3CL Gene COMPARTMENTS Subcellular localization image for TCEB3CL gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TCEB3CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TCEB3CL: view

Pathways & Interactions for TCEB3CL Gene

SuperPathways for TCEB3CL Gene

No Data Available

Interacting Proteins for TCEB3CL Gene

Gene Ontology (GO) - Biological Process for TCEB3CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCEB3CL: view

No data available for Pathways by source and SIGNOR curated interactions for TCEB3CL Gene

Drugs & Compounds for TCEB3CL Gene

No Compound Related Data Available

Transcripts for TCEB3CL Gene

mRNA/cDNA for TCEB3CL Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TCEB3CL Gene

No ASD Table

Relevant External Links for TCEB3CL Gene

GeneLoc Exon Structure for
TCEB3CL
ECgene alternative splicing isoforms for
TCEB3CL

Expression for TCEB3CL Gene

mRNA expression in normal human tissues for TCEB3CL Gene

SOURCE GeneReport for Unigene cluster for TCEB3CL Gene Hs.745535

genes like me logo Genes that share expression patterns with TCEB3CL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TCEB3CL Gene

Orthologs for TCEB3CL Gene

Evolution for TCEB3CL Gene

ENSEMBL:
Gene Tree for TCEB3CL (if available)
TreeFam:
Gene Tree for TCEB3CL (if available)

No data available for Orthologs for TCEB3CL Gene

Paralogs for TCEB3CL Gene

Paralogs for TCEB3CL Gene

(3) SIMAP similar genes for TCEB3CL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCEB3CL: view

Variants for TCEB3CL Gene

Structural Variations from Database of Genomic Variants (DGV) for TCEB3CL Gene

Variant ID Type Subtype PubMed ID
nsv9629 CNV Gain+Loss 18304495
nsv833639 CNV Loss 17160897
nsv909609 CNV Loss 21882294
nsv509693 CNV Insertion 20534489
nsv821062 CNV Duplication 20802225
esv29643 CNV Gain+Loss 19812545
esv2717038 CNV Deletion 23290073
nsv514871 CNV Complex 21397061
nsv2282 CNV Loss 18451855
nsv2283 CNV Insertion 18451855
dgv3416n71 CNV Gain 21882294
nsv2284 CNV Insertion 18451855
esv2717039 CNV Deletion 23290073
nsv833640 CNV Loss 17160897
nsv471406 CNV Duplication 19718026

Variation tolerance for TCEB3CL Gene

Gene Damage Index Score: 0.05; 1.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for TCEB3CL Gene

Disorders for TCEB3CL Gene

Relevant External Links for TCEB3CL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEB3CL

No disorders were found for TCEB3CL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEB3CL Gene

Publications for TCEB3CL Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TCEB3CL Gene

Sources for TCEB3CL Gene

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