TCEB3CL Gene
protein-coding GIFtS: 35
GCID: GC18M044548
|
|
transcription elongation factor B polypeptide 3C-like
| |
Aliases
for TCEB3CL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transcription Elongation Factor B Polypeptide 3C-Like1 2 | | Elongin-A3-Like-11 | | HsT8281 2 | | RNA Polymerase II Transcription Factor SIII Subunit A3-Like-12 | | Transcription Elongation Factor B Polypeptide 3C-Like-12 3 | | EloA3-Like-11 | | EloA3-Like-11 | | Elongin-A3-Like-11 |
Export aliases for TCEB3CL gene to outside databasesPrevious GC identifers: GC00U914143 GC18U900196 GC18M042805 |
Summaries
for TCEB3CL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: EA3L1_HUMAN, Q3SY89Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymeraseII transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but itstranscription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C(elongin BC complex) (By similarity)
|
Genomic Views
for TCEB3CL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TCEB3CL gene promoter:
NF-kappaB HNF-1A YY1 HEN1 AREB6 HNF-1 IRF-7A NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCEB3CL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEB3CL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q21.1 Ensembl cytogenetic band: 18q21.1 HGNC cytogenetic band: 18q21.1TCEB3CL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M044548: view genomic region
(about GC identifiers)
Start:
|
44,548,658 bp from pter |
End:
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44,550,534 bp from pter |
Size:
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1,877 bases |
Orientation:
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minus strand |
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Proteins
for TCEB3CL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EA3L1_HUMAN, Q3SY89 (See
protein sequence)Recommended Name: RNA polymerase II transcription factor SIII subunit A3-like-1 Size: 546 amino acids; 59758 Da
Subunit: Heterotrimer of an A (A1, A2 or A3), B and C subunit (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q3MI93Explore the universe of human proteins at neXtProt for TCEB3CL: NX_Q3SY89
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q3SY89
TCEB3CL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001094287.1
ENSEMBL proteins: ENSP00000409932
Human Recombinant Protein Products for TCEB3CL:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TCEB3CL for ontologies About GeneDecksing
TCEB3CL Antibody Products:
Assay Products for TCEB3CL: |
Protein
Domains /
Families
for TCEB3CL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCEB3CL for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q3SY89ProtoNet protein and cluster: Q3SY89 1 Blocks protein family: IPB010684 RNA polymerase II transcription factor SIII subunit A
UniProtKB/Swiss-Prot: EA3L1_HUMAN, Q3SY89Domain: The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]Similarity: Contains 1 TFIIS N-terminal domain |
Function
for TCEB3CL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: EA3L1_HUMAN, Q3SY89Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymeraseII transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but itstranscription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C(elongin BC complex) (By similarity) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
TCEB3CL for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEB3CL
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEB3CL |
|
Pathways & Interactions
for TCEB3CL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCEB3CL
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TCEB3CL (ENSP000004099324) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
TCEB3CL for ontologies About GeneDecksing
|
Drugs & Compounds
for TCEB3CL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TCEB3CL
Search CenterWatch for drugs/clinical trials and news about TCEB3CL / EA3L1
|
Transcripts
for TCEB3CL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCEB3CL gene: NM_001100817.1 Unigene Cluster for TCEB3CL: Transcription elongation factor B polypeptide 3C-like Hs.515381 Unigene Representative Sequence: BC1039131 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000451265(uc021ujl.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCEB3CL
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEB3CL
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TCEB3CL | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCEB3CL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEB3CL |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCEB3CL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TCEB3CL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCEB3CL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEB3CL |
Additional cDNA sequence: AB076840.1 BC103912.1 BC103913.1 1 DOTS entry: DT.99999629
GeneLoc Exon Structure
|
Expression
for TCEB3CL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCEB3CL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TCEB3CL Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.515381
SABiosciences Custom PCR Arrays for TCEB3CL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCEB3CL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TCEB3CL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCEB3CL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEB3CL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEB3CL |
Orthologs
for TCEB3CL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TCEB3CL gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TCEB36 |
elongin A |
28(a) |
1 → many |
23(5842349-5853476) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
28(a) |
1 → many |
GL343498.1(149248-165168) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:555736 |
zgc:55573 |
29(a) |
1 → many |
19(45359678-45381419) |
fruit fly
(Drosophila melanogaster) |
Insecta |
EloA6 |
Elongin A |
19(a) |
1 → many |
3R(19077266-19080793) |
worm
(Caenorhabditis elegans) |
Secernentea |
R03D7.46 |
Transcription elongation factor B polypeptide 3 |
20(a) |
1 → many |
II(10943331-10945600) |
ENSEMBL Gene Tree for TCEB3CL (if available)
TreeFam Gene Tree for TCEB3CL (if available) |
Paralogs
for TCEB3CL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TCEB3CL gene
- TCEB3CL21 2 TCEB3C1 2 TCEB32 TCEB3B2
3 SIMAP similar genes for TCEB3CL using alignment to 1 protein entry: EA3L1_HUMAN:TCEB3C TCEB3CL2 TCEB3B
TCEB3CL for paralogs About GeneDecksing
|
Genomic Variants
for TCEB3CL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 17 variations for TCEB3CL
15/17 CNVs (see all 17): 35562 35566 35565 35552 5055 35564 73139 35550 35567 77873 73140 32213 88828 5054 35563 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TCEB3CL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCEB3CL for disorders About GeneDecksing
1  disease for TCEB3CL: About MalaCardstinea capitis
1 disease from the University of Copenhagen DISEASES database for TCEB3CL:Tinea capitis Export disorders for TCEB3CL gene to outside databases
|
Publications
for TCEB3CL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCEB3CL gene integrated from 9 sources:
(articles sorted by number of sources associating them with TCEB3CL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TCEB3CL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TCEB3CL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCEB3CL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCEB3CL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TCEB3CL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TCEB3CL gene:
Search GeneIP for patents involving TCEB3CL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCEB3CL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEB3CL |
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