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Aliases for TCEB3C Gene

Aliases for TCEB3C Gene

  • Transcription Elongation Factor B Polypeptide 3C (Elongin A3) 2 3
  • Elongin-A3 3 4
  • TCEB3L2 3 4
  • EloA3 3 4
  • Transcription Elongation Factor B Polypeptide 3C 4
  • Elongin A3 2
  • HsT829 3

External Ids for TCEB3C Gene

Previous GeneCards Identifiers for TCEB3C Gene

  • GC18M042806
  • GC18M042809
  • GC18M044554
  • GC18M041402
  • GC18M047034

Summaries for TCEB3C Gene

Entrez Gene Summary for TCEB3C Gene

  • The SIII (or elongin) transcription elongation factor complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. This complex is a heterotrimer, composed of the transcriptionally active subunit A, A2 or A3 (or elongin A, A2 or A3) and two regulatory subunits, B and C (or elongin B and C). This gene encodes subunit A3. A3 and A are ubiquitously expressed, whereas A2 is specifically expressed in the testis. [provided by RefSeq, Mar 2010]

GeneCards Summary for TCEB3C Gene

TCEB3C (Transcription Elongation Factor B Polypeptide 3C (Elongin A3)) is a Protein Coding gene. An important paralog of this gene is TCEB3B.

UniProtKB/Swiss-Prot for TCEB3C Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEB3C Gene

Genomics for TCEB3C Gene

Regulatory Elements for TCEB3C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TCEB3C Gene

Chromosome:
18
Start:
47,028,202 bp from pter
End:
47,030,078 bp from pter
Size:
1,877 bases
Orientation:
Minus strand

Genomic View for TCEB3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEB3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEB3C Gene

Proteins for TCEB3C Gene

  • Protein details for TCEB3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG57-ELOA3_HUMAN
    Recommended name:
    RNA polymerase II transcription factor SIII subunit A3
    Protein Accession:
    Q8NG57

    Protein attributes for TCEB3C Gene

    Size:
    546 amino acids
    Molecular mass:
    59744 Da
    Quaternary structure:
    • Heterotrimer of an A (A1, A2 or A3), B and C subunit.

neXtProt entry for TCEB3C Gene

Proteomics data for TCEB3C Gene at MOPED

Post-translational modifications for TCEB3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEB3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCEB3C Gene

Domains & Families for TCEB3C Gene

Protein Domains for TCEB3C Gene

Suggested Antigen Peptide Sequences for TCEB3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG57

UniProtKB/Swiss-Prot:

ELOA3_HUMAN :
  • The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]
Domain:
  • The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]
  • Contains 1 TFIIS N-terminal domain.
genes like me logo Genes that share domains with TCEB3C: view

No data available for Gene Families for TCEB3C Gene

Function for TCEB3C Gene

Molecular function for TCEB3C Gene

UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Gene Ontology (GO) - Molecular Function for TCEB3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with TCEB3C: view

Phenotypes for TCEB3C Gene

GenomeRNAi human phenotypes for TCEB3C:
genes like me logo Genes that share phenotypes with TCEB3C: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCEB3C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCEB3C Gene

Localization for TCEB3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEB3C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEB3C Gene COMPARTMENTS Subcellular localization image for TCEB3C gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TCEB3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0016021 integral component of membrane IEA --
GO:0070449 elongin complex IBA --
genes like me logo Genes that share ontologies with TCEB3C: view

Pathways & Interactions for TCEB3C Gene

SuperPathways for TCEB3C Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCEB3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006368 transcription elongation from RNA polymerase II promoter IBA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with TCEB3C: view

No data available for Pathways by source and SIGNOR curated interactions for TCEB3C Gene

Drugs & Compounds for TCEB3C Gene

No Compound Related Data Available

Transcripts for TCEB3C Gene

mRNA/cDNA for TCEB3C Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCEB3C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEB3C Gene

No ASD Table

Relevant External Links for TCEB3C Gene

GeneLoc Exon Structure for
TCEB3C
ECgene alternative splicing isoforms for
TCEB3C

Expression for TCEB3C Gene

mRNA expression in normal human tissues for TCEB3C Gene

mRNA differential expression in normal tissues according to GTEx for TCEB3C Gene

This gene is overexpressed in Testis (x7.1).

SOURCE GeneReport for Unigene cluster for TCEB3C Gene Hs.515381

mRNA Expression by UniProt/SwissProt for TCEB3C Gene

Q8NG57-ELOA3_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expression patterns with TCEB3C: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TCEB3C Gene

Orthologs for TCEB3C Gene

This gene was present in the common ancestor of animals.

Orthologs for TCEB3C Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 92 (a)
OneToMany
chicken
(Gallus gallus)
Aves TCEB3 36
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tceb3 36
  • 27 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta EloA 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R03D7.4 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for TCEB3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TCEB3C Gene

ENSEMBL:
Gene Tree for TCEB3C (if available)
TreeFam:
Gene Tree for TCEB3C (if available)

Paralogs for TCEB3C Gene

Paralogs for TCEB3C Gene

(3) SIMAP similar genes for TCEB3C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCEB3C: view

Variants for TCEB3C Gene

Sequence variations from dbSNP and Humsavar for TCEB3C Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
VAR_059654 -

Structural Variations from Database of Genomic Variants (DGV) for TCEB3C Gene

Variant ID Type Subtype PubMed ID
nsv9629 CNV Gain+Loss 18304495
nsv833639 CNV Loss 17160897
nsv909609 CNV Loss 21882294
nsv509693 CNV Insertion 20534489
nsv821062 CNV Duplication 20802225
esv29643 CNV Gain+Loss 19812545
esv2717038 CNV Deletion 23290073
nsv514871 CNV Complex 21397061
nsv2282 CNV Loss 18451855
nsv2283 CNV Insertion 18451855
dgv3416n71 CNV Gain 21882294
nsv2284 CNV Insertion 18451855
esv2717039 CNV Deletion 23290073
nsv833640 CNV Loss 17160897
nsv471406 CNV Duplication 19718026

Variation tolerance for TCEB3C Gene

Gene Damage Index Score: 0.05; 1.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEB3C Gene

HapMap Linkage Disequilibrium report
TCEB3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCEB3C Gene

Disorders for TCEB3C Gene

Relevant External Links for TCEB3C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEB3C
genes like me logo Genes that share disorders with TCEB3C: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEB3C Gene

Publications for TCEB3C Gene

  1. A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. (PMID: 11932239) Strichman-Almashanu L.Z. … Feinberg A.P. (Genome Res. 2002) 2 23 67
  2. Identification and biochemical characterization of a novel transcription elongation factor, elongin A3. (PMID: 11994304) Yamazaki K. … Aso T. (J. Biol. Chem. 2002) 2 67
  3. Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics. (PMID: 15717329) Crockett D.K. … Lim M.S. (Proteomics 2005) 67
  4. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for TCEB3C Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TCEB3C
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TCEB3C
    • Block miRNA regulation of TCEB3C using miScript Target Protectors

    Sources for TCEB3C Gene

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