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TCEB3C Gene

protein-coding   GIFtS: 42
GCID: GC18M044554

Transcription Elongation Factor B Polypeptide 3C (Elongin...

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Elongation Factor B Polypeptide 3C (Elongin A3)1 2     elongin-A32
TCEB3L22 3     RNA Polymerase II Transcription Factor SIII Subunit A32
Elongin A31     EloA33
HsT8292     Elongin-A33
eloA32     Transcription Elongation Factor B Polypeptide 3C3

External Ids:    HGNC: 246171   Entrez Gene: 1626992   Ensembl: ENSG000001837917   UniProtKB: Q8NG573   

Export aliases for TCEB3C gene to outside databases

Previous GC identifers: GC18M042806 GC18M042809 GC18M041402


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCEB3C Gene:
The SIII (or elongin) transcription elongation factor complex stimulates the rate of transcription elongation by
RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template.
This complex is a heterotrimer, composed of the transcriptionally active subunit A, A2 or A3 (or elongin A, A2 or
A3) and two regulatory subunits, B and C (or elongin B and C). This gene encodes subunit A3. A3 and A are
ubiquitously expressed, whereas A2 is specifically expressed in the testis. (provided by RefSeq, Mar 2010)

GeneCards Summary for TCEB3C Gene:
TCEB3C (transcription elongation factor B polypeptide 3C (elongin A3)) is a protein-coding gene. Diseases associated with TCEB3C include tinea capitis. An important paralog of this gene is TCEB3.

UniProtKB/Swiss-Prot: ELOA3_HUMAN, Q8NG57
Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA
polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally
active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory
subunits B and C (elongin BC complex)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCEB3C gene promoter:
         NF-kappaB   HNF-1A   YY1   HEN1   AREB6   HNF-1   IRF-7A   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCEB3C promoter sequence
   Search Chromatin IP Primers for TCEB3C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCEB3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21.1

TCEB3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEB3C gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M044554:  view genomic region     (about GC identifiers)

Start:
44,554,573 bp from pter      End:
44,556,449 bp from pter
Size:
1,877 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ELOA3_HUMAN, Q8NG57 (See protein sequence)
Recommended Name: RNA polymerase II transcription factor SIII subunit A3  
Size: 546 amino acids; 59744 Da
Subunit: Heterotrimer of an A (A1, A2 or A3), B and C subunit

Explore the universe of human proteins at neXtProt for TCEB3C: NX_Q8NG57

Explore proteomics data for TCEB3C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TCEB3C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_663628.2  
    ENSEMBL proteins: 
     ENSP00000328232  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR010684 RNA_pol_II_trans_fac_SIII_A
     IPR017923 TFIIS_N

    Graphical View of Domain Structure for InterPro Entry Q8NG57

    ProtoNet protein and cluster: Q8NG57

    1 Blocks protein domain: IPB010684 RNA polymerase II transcription factor SIII subunit A

    UniProtKB/Swiss-Prot: ELOA3_HUMAN, Q8NG57
    Domain: The elongin BC complex binding domain is also known as BC-box with the consensus
    [APST]-L-x(3)-C-x(3)-[AILV]
    Similarity: Contains 1 TFIIS N-terminal domain


    TCEB3C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELOA3_HUMAN, Q8NG57
    Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA
    polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally
    active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory
    subunits B and C (elongin BC complex)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    TCEB3C for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ELOA3_HUMAN, Q8NG57: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0016021integral component of membrane IEA--

    TCEB3C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCEB3C
    Interactions:

        Search GeneGlobe Interaction Network for TCEB3C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for TCEB3C (Q8NG573 ENSP000003282324) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTENP604843, ENSP000003610214I2D: score=1 STRING: ENSP00000361021
    TCEB2Q153703, ENSP000002623064I2D: score=1 STRING: ENSP00000262306
    TCEB1Q153693, ENSP000002848114I2D: score=1 STRING: ENSP00000284811
    APCP250543I2D: score=1 
    SKP1ENSP000002314874STRING: ENSP00000231487
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    TCEB3C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCEB3C (ELOA3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TCEB3C gene: 
    NM_145653.3  

    Unigene Cluster for TCEB3C:

    Transcription elongation factor B polypeptide 3C (elongin A3)
    Hs.515381
    Unigene Representative Sequence: NM_145653
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000330682(uc010xdb.2)
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      QuantiFast Probe-based Assays in human, mouse, rat TCEB3C

    Additional mRNA sequence: AB076840.1 

    1 DOTS entry:

    DT.99999629 

    2 AceView cDNA sequences:

    NM_145653 AB076840 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCEB3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TCEB3C Expression
    About this image

    TCEB3C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCEB3C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515381

    UniProtKB/Swiss-Prot: ELOA3_HUMAN, Q8NG57
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TCEB3C gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    Uncharacterized protein
    29(a)
    22(a)
    many ↔ many
    many ↔ many
    4(360072146-360091182)
    X(30374740-30377328)
    chicken
    (Gallus gallus)
    Aves TCEB36
    Gallus gallus transcription elongation factor B (S...
    24(a)
    1 → many
    23(5518731-5536543)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    28(a)
    1 → many
    GL343498.1(149248-165168)
    zebrafish
    (Danio rerio)
    Actinopterygii tceb36
    transcription elongation factor B (SIII), polypept...
    27(a)
    1 → many
    19(45359678-45381419) ENSDARG00000011637
    fruit fly
    (Drosophila melanogaster)
    Insecta EloA6
    Elongin A
    21(a)
    1 → many
    3R(19077266-19080793)
    worm
    (Caenorhabditis elegans)
    Secernentea R03D7.46
    Protein R03D7.4 (R03D7.4) mRNA, complete cds
    20(a)
    1 → many
    II(10943391-10945660) WBGene00010990


    ENSEMBL Gene Tree for TCEB3C (if available)
    TreeFam Gene Tree for TCEB3C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCEB3C gene
    LOC101930171  TCEB3CL1 2  TCEB3CL21 2  TCEB32  TCEB3B2  
    3 SIMAP similar genes for TCEB3C using alignment to 1 protein entry:     ELOA3_HUMAN:
    TCEB3CL    TCEB3CL2    TCEB3B

    TCEB3C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for TCEB3C    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836761011,2
    --44554324(+) ACTTCG/TTGATT 1 -- us2k10--------
    rs22612911,2,4
    ----see VAR_0596542 mis40--------

    HapMap Linkage Disequilibrium report for TCEB3C (44554573 - 44556449 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TCEB3C (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717038CNV Deletion23290073
    esv2717039CNV Deletion23290073
    nsv821062CNV Duplication20802225
    nsv471406CNV Duplication19718026
    nsv2284CNV Insertion18451855
    nsv509693CNV Insertion20534489
    nsv2283CNV Insertion18451855
    nsv833639CNV Loss17160897
    nsv833640CNV Loss17160897
    nsv2282CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TCEB3C:    
    About MalaCards
    tinea capitis

    1 disease from the University of Copenhagen DISEASES database for TCEB3C:
    Tinea capitis

    TCEB3C for disorders           About GeneDecksing


    Export disorders for TCEB3C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCEB3C gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TCEB3C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and biochemical characterization of a novel transcription elongation factor, elongin A3. (PubMed id 11994304)1, 2, 3 Yamazaki K.... Aso T. (J. Biol. Chem. 2002)
    2. A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. (PubMed id 11932239)1, 3, 9 Strichman-Almashanu L.Z....Feinberg A.P. (Genome Res. 2002)
    3. Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics. (PubMed id 15717329)1 Crockett D.K....Lim M.S. (Proteomics 2005)
    4. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (Nature 2005)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 162699 HGNC: 24617 AceView: TCEB3C Ensembl:ENSG00000183791 euGenes: HUgn162699
    ECgene: TCEB3C H-InvDB: TCEB3C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCEB3C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCEB3C gene:
    Search GeneIP for patents involving TCEB3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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