TCEB3C Gene
protein-coding GIFtS: 40
GCID: GC18M044554
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transcription elongation factor B polypeptide 3C (elongin...
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Aliases
for TCEB3C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transcription Elongation Factor B Polypeptide 3C (Elongin A3)1 2 | | RNA Polymerase II Transcription Factor SIII Subunit A32 | | TCEB3L21 2 3 | | EloA33 | | HsT8291 2 | | Elongin-A33 | | EloA33 | | Transcription Elongation Factor B Polypeptide 3C3 | | Elongin-A33 | | |
Export aliases for TCEB3C gene to outside databasesPrevious GC identifers: GC18M042806 GC18M042809 GC18M041402 |
Summaries
for TCEB3C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TCEB3C:
The SIII (or elongin) transcription elongation factor complex stimulates the rate of transcription elongation by RNApolymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. Thiscomplex is a heterotrimer, composed of the transcriptionally active subunit A, A2 or A3 (or elongin A, A2 or A3) andtwo regulatory subunits, B and C (or elongin B and C). This gene encodes subunit A3. A3 and A are ubiquitouslyexpressed, whereas A2 is specifically expressed in the testis. (provided by RefSeq, Mar 2010)
UniProtKB/Swiss-Prot: ELOA3_HUMAN, Q8NG57Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymeraseII transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but itstranscription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C(elongin BC complex)
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Genomic Views
for TCEB3C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TCEB3C gene promoter:
NF-kappaB HNF-1A YY1 HEN1 AREB6 HNF-1 IRF-7A NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCEB3C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEB3C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q21.1 Ensembl cytogenetic band: 18q21.1 HGNC cytogenetic band: 18q21.1TCEB3C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M044554: view genomic region
(about GC identifiers)
Start:
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44,554,573 bp from pter |
End:
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44,556,449 bp from pter |
Size:
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1,877 bases |
Orientation:
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minus strand |
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Proteins
for TCEB3C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ELOA3_HUMAN, Q8NG57 (See
protein sequence)Recommended Name: RNA polymerase II transcription factor SIII subunit A3 Size: 546 amino acids; 59744 Da
Subunit: Heterotrimer of an A (A1, A2 or A3), B and C subunit
Subcellular location: NucleusExplore the universe of human proteins at neXtProt for TCEB3C: NX_Q8NG57
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NG57
TCEB3C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_663628.2
ENSEMBL proteins: ENSP00000328232
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TCEB3C for ontologies About GeneDecksing
TCEB3C Antibody Products:
Assay Products for TCEB3C: |
Protein
Domains /
Families
for TCEB3C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCEB3C for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NG57ProtoNet protein and cluster: Q8NG57 1 Blocks protein family: IPB010684 RNA polymerase II transcription factor SIII subunit A
UniProtKB/Swiss-Prot: ELOA3_HUMAN, Q8NG57Domain: The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]Similarity: Contains 1 TFIIS N-terminal domain |
Function
for TCEB3C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ELOA3_HUMAN, Q8NG57Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymeraseII transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but itstranscription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C(elongin BC complex)
Clone
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
TCEB3C for ontologies About GeneDecksing
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Pathways & Interactions
for TCEB3C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCEB3C
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for TCEB3C (Q8NG573 ENSP000003282324) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
TCEB3C for ontologies About GeneDecksing
|
Drugs & Compounds
for TCEB3C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TCEB3C
Search CenterWatch for drugs/clinical trials and news about TCEB3C / ELOA3
|
Transcripts
for TCEB3C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCEB3C gene: NM_145653.3 Unigene Cluster for TCEB3C: Transcription elongation factor B polypeptide 3C (elongin A3) Hs.742303 Unigene Representative Sequence: NM_1456531 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000330682(uc010xdb.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCEB3C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEB3C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TCEB3C (NM_145653) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCEB3C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEB3C |
1 DOTS entry: DT.99999629 2 AceView cDNA sequences: NM_145653 AB076840
GeneLoc Exon Structure
|
Expression
for TCEB3C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCEB3C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TCEB3C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCEB3C
SOURCE GeneReport for Unigene cluster: Hs.742303
UniProtKB/Swiss-Prot: ELOA3_HUMAN, Q8NG57Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for TCEB3C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCEB3C
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TCEB3C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCEB3C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEB3C |
Orthologs
for TCEB3C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TCEB3C gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TCEB36 |
elongin A |
28(a) |
1 → many |
23(5842349-5853476) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
28(a) |
1 → many |
GL343498.1(149248-165168) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:555736 |
zgc:55573 |
29(a) |
1 → many |
19(45359678-45381419) |
fruit fly
(Drosophila melanogaster) |
Insecta |
EloA6 |
Elongin A |
19(a) |
1 → many |
3R(19077266-19080793) |
worm
(Caenorhabditis elegans) |
Secernentea |
R03D7.46 |
Transcription elongation factor B polypeptide 3 |
21(a) |
1 → many |
II(10943331-10945600) |
ENSEMBL Gene Tree for TCEB3C (if available)
TreeFam Gene Tree for TCEB3C (if available) |
Paralogs
for TCEB3C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TCEB3C gene
- TCEB3CL1 2 TCEB3CL21 2 TCEB32 TCEB3B2
3 SIMAP similar genes for TCEB3C using alignment to 1 protein entry: ELOA3_HUMAN:TCEB3CL TCEB3CL2 TCEB3B
TCEB3C for paralogs About GeneDecksing
|
Genomic Variants
for TCEB3C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 17 variations for TCEB3C
15/17 CNVs (see all 17): 35562 35566 35565 35552 5055 35564 73139 35550 35567 77873 73140 32213 88828 5054 35563 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCEB3C |
|
Disorders
/ Diseases
for TCEB3C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCEB3C for disorders About GeneDecksing
1  disease for TCEB3C: About MalaCardstinea capitis
1 disease from the University of Copenhagen DISEASES database for TCEB3C:Tinea capitis Export disorders for TCEB3C gene to outside databases
|
Publications
for TCEB3C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCEB3C gene integrated from 9 sources:
(articles sorted by number of sources associating them with TCEB3C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and biochemical characterization of a novel transcription elongation factor, elongin A3. (PubMed id 11994304)1, 2, 3 Yamazaki K.... Aso T. (2002)
- A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. (PubMed id 11932239)1, 3, 9 Strichman-Almashanu L.Z....Feinberg A.P. (2002)
- Analysis of phosphatase and tensin homolog tumor supp ressor interacting proteins by in vitro and in silico proteomics. (PubMed id 15717329)1 Crockett D.K....Lim M.S. (2005)
- DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for TCEB3C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TCEB3C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCEB3C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCEB3C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TCEB3C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TCEB3C gene:
Search GeneIP for patents involving TCEB3C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCEB3C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for TCEB3C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEB3C |
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