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TCEB3B Gene

protein-coding   GIFtS: 46
GCID: GC18M044558

Transcription Elongation Factor B Polypeptide 3B (Elongin...

  See TCEB3B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Elongation Factor B Polypeptide 3B (Elongin A2)1 2     elongin-A22
TCEB3L2 3     RNA Polymerase II Transcription Factor SIII Subunit A22
Elongin A21     Transcription Elongation Factor (SIII) Elongin A2 Elongin A22
Transcription Elongation Factor (SIII) Elongin A21     EloA23
ELOA22     Elongin-A23
HsT8322     Transcription Elongation Factor B Polypeptide 3B3

External Ids:    HGNC: 307711   Entrez Gene: 512242   Ensembl: ENSG000002061817   OMIM: 6095225   UniProtKB: Q8IYF13   

Export aliases for TCEB3B gene to outside databases

Previous GC identifers: GC18M042811 GC18M042808 GC18M042812 GC18M041406


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCEB3B Gene:
This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor
complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of
RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along
the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the
encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TCEB3B Gene:
TCEB3B (transcription elongation factor B polypeptide 3B (elongin A2)) is a protein-coding gene. Diseases associated with TCEB3B include breast and colorectal cancer. An important paralog of this gene is TCEB3.

UniProtKB/Swiss-Prot: ELOA2_HUMAN, Q8IYF1
Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA
polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally
active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory
subunits B and C (elongin BC complex)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCEB3B gene promoter:
         STAT1   NF-kappaB   STAT1alpha   HNF-1A   YY1   HEN1   AREB6   HNF-1   IRF-7A   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCEB3B promoter sequence
   Search Chromatin IP Primers for TCEB3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCEB3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21.1

TCEB3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEB3B gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M044558:  view genomic region     (about GC identifiers)

Start:
44,558,943 bp from pter      End:
44,561,988 bp from pter
Size:
3,046 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ELOA2_HUMAN, Q8IYF1 (See protein sequence)
Recommended Name: RNA polymerase II transcription factor SIII subunit A2  
Size: 753 amino acids; 83921 Da
Subunit: Heterotrimer of an A (A1, A2 or A3), B and C subunit
Secondary accessions: Q9P2V9

Explore the universe of human proteins at neXtProt for TCEB3B: NX_Q8IYF1

Explore proteomics data for TCEB3B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TCEB3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057511.2  
    ENSEMBL proteins: 
     ENSP00000331302  

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    Search eBioscience for ELISAs for TCEB3B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR003617 TFIIS/CRSP70_N_sub
     IPR010684 RNA_pol_II_trans_fac_SIII_A
     IPR017923 TFIIS_N

    Graphical View of Domain Structure for InterPro Entry Q8IYF1

    ProtoNet protein and cluster: Q8IYF1

    1 Blocks protein domain: IPB010684 RNA polymerase II transcription factor SIII subunit A

    UniProtKB/Swiss-Prot: ELOA2_HUMAN, Q8IYF1
    Domain: The elongin BC complex binding domain is also known as BC-box with the consensus
    [APST]-L-x(3)-C-x(3)-[AILV]
    Similarity: Contains 1 TFIIS N-terminal domain


    Find genes that share domains with TCEB3B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELOA2_HUMAN, Q8IYF1
    Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA
    polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally
    active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory
    subunits B and C (elongin BC complex)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    Find genes that share ontologies with TCEB3B           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ELOA2_HUMAN, Q8IYF1: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TCEB3B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCEB3B
    Interactions:

        Search GeneGlobe Interaction Network for TCEB3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TCEB3B (Q8IYF12, 3 ENSP000003313024) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP70Q8NHQ12, 3, ENSP000002649824MINT-68144 I2D: score=5 STRING: ENSP00000264982
    TRIM37O949722, 3, ENSP000002622944MINT-66227 I2D: score=5 STRING: ENSP00000262294
    DVL2O146412, 3, ENSP000000053404MINT-67085 I2D: score=5 STRING: ENSP00000005340
    SOHLH2Q9NX452, 3, ENSP000003692104MINT-67917 I2D: score=5 STRING: ENSP00000369210
    CBX5P459732, 3, ENSP000002098754MINT-68195 I2D: score=5 STRING: ENSP00000209875
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS10692460
    GO:0032784regulation of DNA-templated transcription, elongation TAS10692460

    Find genes that share ontologies with TCEB3B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCEB3B (ELOA2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TCEB3B gene: 
    NM_016427.2  

    Unigene Cluster for TCEB3B:

    Transcription elongation factor B polypeptide 3B (elongin A2)
    Hs.375035  [show with all ESTs]
    Unigene Representative Sequence: BC036022
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000332567(uc002lcr.1)
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      QuantiFast Probe-based Assays in human, mouse, rat TCEB3B

    Additional mRNA sequence: 

    AB030834.1 AK314984.1 BC036022.1 BC103911.2 

    1 DOTS entry:

    DT.75192072 

    5 AceView cDNA sequences:

    NM_016427 BC036022 AA861139 AB030834 BI463083 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCEB3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGGCCCT
    TCEB3B Expression
    About this image

    TCEB3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCEB3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.375035

    UniProtKB/Swiss-Prot: ELOA2_HUMAN, Q8IYF1
    Tissue specificity: Specifically expressed in testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TCEB3B gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    Uncharacterized protein
    36(a)
    26(a)
    many ↔ many
    many ↔ many
    4(360072146-360091182)
    X(30374740-30377328)
    chicken
    (Gallus gallus)
    Aves TCEB36
    Gallus gallus transcription elongation factor B (S...
    29(a)
    1 → many
    23(5518731-5536543)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    32(a)
    1 → many
    GL343498.1(149248-165168)
    zebrafish
    (Danio rerio)
    Actinopterygii tceb36
    transcription elongation factor B (SIII), polypept...
    31(a)
    1 → many
    19(45359678-45381419) ENSDARG00000011637
    fruit fly
    (Drosophila melanogaster)
    Insecta EloA6
    Elongin A
    24(a)
    1 → many
    3R(19077266-19080793)
    worm
    (Caenorhabditis elegans)
    Secernentea R03D7.46
    Protein R03D7.4 (R03D7.4) mRNA, complete cds
    21(a)
    1 → many
    II(10943391-10945660) WBGene00010990


    ENSEMBL Gene Tree for TCEB3B (if available)
    TreeFam Gene Tree for TCEB3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCEB3B gene
    TCEB32  TCEB3CL2  TCEB3CL22  TCEB3C2  
    4 SIMAP similar genes for TCEB3B using alignment to 2 protein entries:     ELOA2_HUMAN (see all proteins):
    TCEB3    TCEB3C    TCEB3CL    TCEB3CL2

    Find genes that share paralogs with TCEB3B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    5 SNPs for TCEB3B    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359144
    A colorectal cancer sample4--see VAR_0359142 R Q mis40--------
    rs37448631,2,4
    ----see VAR_0616462 mis40--------
    rs20108341,2,4
    ----see VAR_0509662 mis40--------
    rs25710281,2,4
    ----see VAR_0509652 mis40--------
    rs8925861,2,4
    ----see VAR_0509672 mis40--------

    HapMap Linkage Disequilibrium report for TCEB3B (44558943 - 44561988 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TCEB3B (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2284CNV Insertion18451855
    nsv509693CNV Insertion20534489
    nsv833640CNV Loss17160897
    nsv2282CNV Loss18451855
    nsv909609CNV Loss21882294
    esv998188CNV Gain20482838
    dgv3416n71CNV Gain21882294
    nsv828225CNV Gain20364138
    nsv909612CNV Gain21882294
    nsv9629CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609522    OMIM disorders: --

    1 disease for TCEB3B:    
    About MalaCards
    breast and colorectal cancer


    Find genes that share disorders with TCEB3B           About GenesLikeMe


    Export disorders for TCEB3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCEB3B gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with TCEB3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis. (PubMed id 10692460)1, 2, 9 Aso T.... Hatakeyama M. (J. Biol. Chem. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. (PubMed id 7660129)1, 3 Aso T....Conaway R.C. (Science 1995)
    4. RNA polymerase II transcription factor SIII. I. Identification, purification, and properties. (PubMed id 8244996)1, 3 Bradsher J.N....Conaway J.W. (J. Biol. Chem. 1993)
    5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    6. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. (PubMed id 22094256)1 Anders L....Sicinski P. (Cancer Cell 2011)
    7. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    8. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51224 HGNC: 30771 AceView: TCEB3B Ensembl:ENSG00000206181 euGenes: HUgn51224
    ECgene: TCEB3B H-InvDB: TCEB3B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCEB3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCEB3B gene:
    Search GeneIP for patents involving TCEB3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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