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Aliases for TCEB3B Gene

Aliases for TCEB3B Gene

  • Transcription Elongation Factor B Subunit 3B 2 3
  • Transcription Elongation Factor B Polypeptide 3B (Elongin A2) 2 3 5
  • Elongin-A2 3 4
  • TCEB3L 3 4
  • ELOA2 3 4
  • Transcription Elongation Factor (SIII) Elongin A2 Elongin A2 3
  • Transcription Elongation Factor (SIII) Elongin A2 2
  • Transcription Elongation Factor B Polypeptide 3B 4
  • Elongin A2 2
  • HsT832 3

External Ids for TCEB3B Gene

Previous GeneCards Identifiers for TCEB3B Gene

  • GC18M042811
  • GC18M042808
  • GC18M042812
  • GC18M044558
  • GC18M041406
  • GC18M047035
  • GC18M047037

Summaries for TCEB3B Gene

Entrez Gene Summary for TCEB3B Gene

  • This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEB3B Gene

TCEB3B (Transcription Elongation Factor B Subunit 3B) is a Protein Coding gene. An important paralog of this gene is TCEB3C.

UniProtKB/Swiss-Prot for TCEB3B Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEB3B Gene

Genomics for TCEB3B Gene

Regulatory Elements for TCEB3B Gene

Enhancers for TCEB3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TCEB3B on UCSC Golden Path with GeneCards custom track

Genomic Location for TCEB3B Gene

Chromosome:
18
Start:
47,032,572 bp from pter
End:
47,035,621 bp from pter
Size:
3,050 bases
Orientation:
Minus strand

Genomic View for TCEB3B Gene

Genes around TCEB3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEB3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEB3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEB3B Gene

Proteins for TCEB3B Gene

  • Protein details for TCEB3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYF1-ELOA2_HUMAN
    Recommended name:
    RNA polymerase II transcription factor SIII subunit A2
    Protein Accession:
    Q8IYF1
    Secondary Accessions:
    • Q9P2V9

    Protein attributes for TCEB3B Gene

    Size:
    753 amino acids
    Molecular mass:
    83921 Da
    Quaternary structure:
    • Heterotrimer of an A (A1, A2 or A3), B and C subunit.

neXtProt entry for TCEB3B Gene

Proteomics data for TCEB3B Gene at MOPED

Post-translational modifications for TCEB3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEB3B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TCEB3B Gene

Domains & Families for TCEB3B Gene

Suggested Antigen Peptide Sequences for TCEB3B Gene

Graphical View of Domain Structure for InterPro Entry

Q8IYF1

UniProtKB/Swiss-Prot:

ELOA2_HUMAN :
  • The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
Domain:
  • The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
  • Contains 1 TFIIS N-terminal domain.
genes like me logo Genes that share domains with TCEB3B: view

No data available for Gene Families for TCEB3B Gene

Function for TCEB3B Gene

Molecular function for TCEB3B Gene

UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Phenotypes for TCEB3B Gene

genes like me logo Genes that share phenotypes with TCEB3B: view

Animal Model Products

miRNA for TCEB3B Gene

miRTarBase miRNAs that target TCEB3B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEB3B Gene

Localization for TCEB3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEB3B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEB3B Gene COMPARTMENTS Subcellular localization image for TCEB3B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TCEB3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TCEB3B: view

Pathways & Interactions for TCEB3B Gene

SuperPathways for TCEB3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCEB3B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCEB3B Gene

Drugs & Compounds for TCEB3B Gene

No Compound Related Data Available

Transcripts for TCEB3B Gene

mRNA/cDNA for TCEB3B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCEB3B Gene

Transcription elongation factor B polypeptide 3B (elongin A2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCEB3B Gene

No ASD Table

Relevant External Links for TCEB3B Gene

GeneLoc Exon Structure for
TCEB3B
ECgene alternative splicing isoforms for
TCEB3B

Expression for TCEB3B Gene

mRNA expression in normal human tissues for TCEB3B Gene

mRNA differential expression in normal tissues according to GTEx for TCEB3B Gene

This gene is overexpressed in Testis (x40.5).

Protein differential expression in normal tissues from HIPED for TCEB3B Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCEB3B Gene



SOURCE GeneReport for Unigene cluster for TCEB3B Gene Hs.375035

mRNA Expression by UniProt/SwissProt for TCEB3B Gene

Q8IYF1-ELOA2_HUMAN
Tissue specificity: Specifically expressed in testis.
genes like me logo Genes that share expression patterns with TCEB3B: view

Protein tissue co-expression partners for TCEB3B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TCEB3B Gene

Orthologs for TCEB3B Gene

This gene was present in the common ancestor of animals.

Orthologs for TCEB3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEB3B 35
  • 97.88 (n)
  • 94.95 (a)
TCEB3B 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
OneToMany
chicken
(Gallus gallus)
Aves TCEB3 36
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tceb3 36
  • 31 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta EloA 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R03D7.4 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for TCEB3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TCEB3B Gene

ENSEMBL:
Gene Tree for TCEB3B (if available)
TreeFam:
Gene Tree for TCEB3B (if available)

Paralogs for TCEB3B Gene

Paralogs for TCEB3B Gene

(4) SIMAP similar genes for TCEB3B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TCEB3B: view

Variants for TCEB3B Gene

Sequence variations from dbSNP and Humsavar for TCEB3B Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
VAR_035914 A colorectal cancer sample
VAR_050965 -
VAR_050966 -
VAR_050967 -
VAR_061646 -

Structural Variations from Database of Genomic Variants (DGV) for TCEB3B Gene

Variant ID Type Subtype PubMed ID
nsv9629 CNV Gain+Loss 18304495
nsv909609 CNV Loss 21882294
nsv509693 CNV Insertion 20534489
nsv514871 CNV Complex 21397061
nsv2282 CNV Loss 18451855
dgv3416n71 CNV Gain 21882294
nsv2284 CNV Insertion 18451855
nsv833640 CNV Loss 17160897
nsv828225 CNV Gain 20364138
esv998188 CNV Gain 20482838
nsv909612 CNV Gain 21882294

Variation tolerance for TCEB3B Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TCEB3B Gene

Disorders for TCEB3B Gene

Relevant External Links for TCEB3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEB3B

No disorders were found for TCEB3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEB3B Gene

Publications for TCEB3B Gene

  1. Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis. (PMID: 10692460) Aso T. … Hatakeyama M. (J. Biol. Chem. 2000) 3 4 23 67
  2. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. (PMID: 7660129) Aso T. … Conaway R.C. (Science 1995) 2 3
  3. RNA polymerase II transcription factor SIII. I. Identification, purification, and properties. (PMID: 8244996) Bradsher J.N. … Conaway J.W. (J. Biol. Chem. 1993) 2 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3

Products for TCEB3B Gene

Sources for TCEB3B Gene

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