Aliases for TCEB3B Gene
External Ids for TCEB3B Gene
Previous GeneCards Identifiers for TCEB3B Gene
This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for TCEB3B Gene
TCEB3B (Transcription Elongation Factor B Polypeptide 3B (Elongin A2)) is a Protein Coding gene. Diseases associated with TCEB3B include colorectal cancer. An important paralog of this gene is TCEB3C.
UniProtKB/Swiss-Prot for TCEB3B Gene
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).