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Aliases for TCEB3B Gene

Aliases for TCEB3B Gene

  • Transcription Elongation Factor B Polypeptide 3B (Elongin A2) 2 3
  • Elongin-A2 3 4
  • TCEB3L 3 4
  • ELOA2 3 4
  • Transcription Elongation Factor (SIII) Elongin A2 Elongin A2 3
  • RNA Polymerase II Transcription Factor SIII Subunit A2 3
  • Transcription Elongation Factor (SIII) Elongin A2 2
  • Transcription Elongation Factor B Polypeptide 3B 4
  • Elongin A2 2
  • HsT832 3

External Ids for TCEB3B Gene

Summaries for TCEB3B Gene

Entrez Gene Summary for TCEB3B Gene

  • This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEB3B Gene

TCEB3B (Transcription Elongation Factor B Polypeptide 3B (Elongin A2)) is a Protein Coding gene. Diseases associated with TCEB3B include colorectal cancer. An important paralog of this gene is TCEB3C.

UniProtKB/Swiss-Prot for TCEB3B Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEB3B Gene

Genomics for TCEB3B Gene

Genomic Location for TCEB3B Gene

Start:
47,032,572 bp from pter
End:
47,035,621 bp from pter
Size:
3,050 bases
Orientation:
Minus strand

Genomic View for TCEB3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEB3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEB3B Gene

Regulatory Elements for TCEB3B Gene

Proteins for TCEB3B Gene

  • Protein details for TCEB3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYF1-ELOA2_HUMAN
    Recommended name:
    RNA polymerase II transcription factor SIII subunit A2
    Protein Accession:
    Q8IYF1
    Secondary Accessions:
    • Q9P2V9

    Protein attributes for TCEB3B Gene

    Size:
    753 amino acids
    Molecular mass:
    83921 Da
    Quaternary structure:
    • Heterotrimer of an A (A1, A2 or A3), B and C subunit.

neXtProt entry for TCEB3B Gene

Proteomics data for TCEB3B Gene at MOPED

Post-translational modifications for TCEB3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEB3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCEB3B Gene

Domains for TCEB3B Gene

UniProtKB/Swiss-Prot:

ELOA2_HUMAN
Domain:
  • The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]:
    • Q8IYF1
  • Contains 1 TFIIS N-terminal domain.:
    • Q8IYF1
genes like me logo Genes that share domains with TCEB3B: view

No data available for Gene Families for TCEB3B Gene

Function for TCEB3B Gene

Molecular function for TCEB3B Gene

UniProtKB/Swiss-Prot Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Gene Ontology (GO) - Molecular Function for TCEB3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TCEB3B: view

miRNA for TCEB3B Gene

miRTarBase miRNAs that target TCEB3B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TCEB3B Gene

Localization for TCEB3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEB3B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEB3B Gene COMPARTMENTS Subcellular localization image for TCEB3B gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TCEB3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TCEB3B: view

Pathways for TCEB3B Gene

SuperPathways for TCEB3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCEB3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter TAS 10692460
GO:0032784 regulation of DNA-templated transcription, elongation TAS 10692460
genes like me logo Genes that share ontologies with TCEB3B: view

No data available for Pathways by source for TCEB3B Gene

Transcripts for TCEB3B Gene

mRNA/cDNA for TCEB3B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCEB3B Gene

Transcription elongation factor B polypeptide 3B (elongin A2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCEB3B Gene

No ASD Table

Relevant External Links for TCEB3B Gene

GeneLoc Exon Structure for
TCEB3B
ECgene alternative splicing isoforms for
TCEB3B

Expression for TCEB3B Gene

mRNA expression in normal human tissues for TCEB3B Gene

mRNA differential expression in normal tissues according to GTEx for TCEB3B Gene

This gene is overexpressed in Testis (40.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TCEB3B Gene

SOURCE GeneReport for Unigene cluster for TCEB3B Gene Hs.375035

mRNA Expression by UniProt/SwissProt for TCEB3B Gene

Q8IYF1-ELOA2_HUMAN
Tissue specificity: Specifically expressed in testis.
genes like me logo Genes that share expressions with TCEB3B: view

Orthologs for TCEB3B Gene

This gene was present in the common ancestor of animals.

Orthologs for TCEB3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEB3B 36
  • 97.88 (n)
  • 94.95 (a)
TCEB3B 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 36 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 34 (a)
OneToMany
chicken
(Gallus gallus)
Aves TCEB3 37
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 32 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tceb3 37
  • 31 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta EloA 37
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R03D7.4 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToMany
Species with no ortholog for TCEB3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TCEB3B Gene

ENSEMBL:
Gene Tree for TCEB3B (if available)
TreeFam:
Gene Tree for TCEB3B (if available)

Paralogs for TCEB3B Gene

Paralogs for TCEB3B Gene

Selected SIMAP similar genes for TCEB3B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TCEB3B: view

Variants for TCEB3B Gene

Sequence variations from dbSNP and Humsavar for TCEB3B Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
VAR_035914 A colorectal cancer sample
VAR_050965 -
VAR_050966 -
VAR_050967 -
VAR_061646 -

Structural Variations from Database of Genomic Variants (DGV) for TCEB3B Gene

Variant ID Type Subtype PubMed ID
nsv9629 CNV Gain+Loss 18304495
nsv909609 CNV Loss 21882294
nsv509693 CNV Insertion 20534489
nsv514871 CNV Complex 21397061
nsv2282 CNV Loss 18451855
dgv3416n71 CNV Gain 21882294
nsv2284 CNV Insertion 18451855
nsv833640 CNV Loss 17160897
nsv828225 CNV Gain 20364138
esv998188 CNV Gain 20482838
nsv909612 CNV Gain 21882294

Relevant External Links for TCEB3B Gene

HapMap Linkage Disequilibrium report
TCEB3B

Disorders for TCEB3B Gene

(1) MalaCards Diseases for TCEB3B Gene

Search for TCEB3B Gene in MalaCards »
genes like me logo Genes that share disorders with TCEB3B: view

No data available for UniProtKB/Swiss-Prot for TCEB3B Gene

Publications for TCEB3B Gene

  1. Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis. (PMID: 10692460) Aso T. … Hatakeyama M. (J. Biol. Chem. 2000) 3 4 23
  2. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. (PMID: 7660129) Aso T. … Conaway R.C. (Science 1995) 2 3
  3. RNA polymerase II transcription factor SIII. I. Identification, purification, and properties. (PMID: 8244996) Bradsher J.N. … Conaway J.W. (J. Biol. Chem. 1993) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for TCEB3B Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TCEB3B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TCEB3B
    • Block miRNA regulation of TCEB3B using miScript Target Protectors

    Sources for TCEB3B Gene

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