TCEB3B Gene
protein-coding GIFtS: 47
GCID: GC18M044558
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transcription elongation factor B polypeptide 3B (elongin...
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Aliases
for TCEB3B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transcription Elongation Factor B Polypeptide 3B (Elongin A2)1 2 | | RNA Polymerase II Transcription Factor SIII Subunit A22 | | TCEB3L1 2 3 | | Transcription Elongation Factor (SIII) Elongin A2 Elongin A22 | | HsT8321 2 | | EloA23 | | ELOA22 | | Elongin-A23 | | Elongin-A23 | | Transcription Elongation Factor B Polypeptide 3B3 |
Export aliases for TCEB3B gene to outside databasesPrevious GC identifers: GC18M042811 GC18M042808 GC18M042812 GC18M041406 |
Summaries
for TCEB3B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TCEB3B:
This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factorcomplex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNAchain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNAtemplate. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded proteinis specifically expressed in the testis, suggesting it may have a role in spermatogenesis. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: ELOA2_HUMAN, Q8IYF1Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymeraseII transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but itstranscription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C(elongin BC complex)
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Genomic Views
for TCEB3B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TCEB3B gene promoter:
STAT1 NF-kappaB STAT1alpha HNF-1A YY1 HEN1 AREB6 HNF-1 IRF-7A NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCEB3B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEB3B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q21.1 Ensembl cytogenetic band: 18q21.1 HGNC cytogenetic band: 18q21.1TCEB3B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M044558: view genomic region
(about GC identifiers)
Start:
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44,558,943 bp from pter |
End:
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44,561,988 bp from pter |
Size:
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3,046 bases |
Orientation:
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minus strand |
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Proteins
for TCEB3B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ELOA2_HUMAN, Q8IYF1 (See
protein sequence)Recommended Name: RNA polymerase II transcription factor SIII subunit A2 Size: 753 amino acids; 83921 Da
Subunit: Heterotrimer of an A (A1, A2 or A3), B and C subunit
Subcellular location: Nucleus (Probable)
Secondary accessions: Q9P2V9Explore the universe of human proteins at neXtProt for TCEB3B: NX_Q8IYF1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYF1
TCEB3B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057511.2
ENSEMBL proteins: ENSP00000331302
Human Recombinant Protein Products for TCEB3B:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TCEB3B for ontologies About GeneDecksing
TCEB3B Antibody Products:
Assay Products for TCEB3B: |
Protein
Domains /
Families
for TCEB3B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCEB3B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IYF1ProtoNet protein and cluster: Q8IYF1 1 Blocks protein family: IPB010684 RNA polymerase II transcription factor SIII subunit A
UniProtKB/Swiss-Prot: ELOA2_HUMAN, Q8IYF1Domain: The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]Similarity: Contains 1 TFIIS N-terminal domain |
Function
for TCEB3B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ELOA2_HUMAN, Q8IYF1Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymeraseII transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but itstranscription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C(elongin BC complex) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
TCEB3B for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEB3B
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEB3B |
|
Pathways & Interactions
for TCEB3B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCEB3B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/23 Interacting proteins for TCEB3B (Q8IYF12, 3 ENSP000003313024) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 10692460 | | GO:0032784 | regulation of DNA-dependent transcription, elongation |
TAS | 10692460 |
TCEB3B for ontologies About GeneDecksing
|
Drugs & Compounds
for TCEB3B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TCEB3B
Search CenterWatch for drugs/clinical trials and news about TCEB3B / ELOA2
|
Transcripts
for TCEB3B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCEB3B gene: NM_016427.2 Unigene Cluster for TCEB3B: Transcription elongation factor B polypeptide 3B (elongin A2) Hs.375035 [show with all ESTs]Unigene Representative Sequence: BC0360221 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000332567(uc002lcr.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCEB3B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEB3B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TCEB3B (NM_016427) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCEB3B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEB3B |
Additional cDNA sequence: AB030834.1 AK314984.1 BC036022.1 BC103911.2 1 DOTS entry: DT.75192072 5 AceView cDNA sequences: BC036022 NM_016427 AA861139 AB030834 BI463083
GeneLoc Exon Structure
|
Expression
for TCEB3B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCEB3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTGGCCCT
About this image
See TCEB3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCEB3B
SOURCE GeneReport for Unigene cluster: Hs.375035
UniProtKB/Swiss-Prot: ELOA2_HUMAN, Q8IYF1Tissue specificity: Specifically expressed in testis
SABiosciences Custom PCR Arrays for TCEB3B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCEB3B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TCEB3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCEB3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEB3B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEB3B |
Orthologs
for TCEB3B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TCEB3B gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TCEB36 |
elongin A |
35(a) |
1 → many |
23(5842349-5853476) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
34(a) |
1 → many |
GL343498.1(149248-165168) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:555736 |
zgc:55573 |
30(a) |
1 → many |
19(45359678-45381419) |
fruit fly
(Drosophila melanogaster) |
Insecta |
EloA6 |
Elongin A |
20(a) |
1 → many |
3R(19077266-19080793) |
worm
(Caenorhabditis elegans) |
Secernentea |
R03D7.46 |
Transcription elongation factor B polypeptide 3 |
21(a) |
1 → many |
II(10943331-10945600) |
Species with no ortholog for TCEB3B
ENSEMBL Gene Tree for TCEB3B (if available)
TreeFam Gene Tree for TCEB3B (if available) |
Paralogs
for TCEB3B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TCEB3B gene
- TCEB32 TCEB3CL2 TCEB3CL22 TCEB3C2
4 SIMAP similar genes for TCEB3B using alignment to 2 protein entries: ELOA2_HUMAN (see all proteins):TCEB3 TCEB3C TCEB3CL TCEB3CL2
TCEB3B for paralogs About GeneDecksing
|
Genomic Variants
for TCEB3B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TCEB3B (44558943 - 44561988 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for TCEB3B
10 CNVs: 35567 35550 77873 32213 35566 88828 35565 30870 5055 35564 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCEB3B |
|
Disorders
/ Diseases
for TCEB3B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCEB3B for disorders About GeneDecksing
OMIM gene information: 609522
OMIM disorders: --
2  diseases for TCEB3B: About MalaCardsteratoma ataxia
Export disorders for TCEB3B gene to outside databases
|
Publications
for TCEB3B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCEB3B gene integrated from 9 sources:
(articles sorted by number of sources associating them with TCEB3B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis. (PubMed id 10692460)1, 2, 9 Aso T.... Hatakeyama M. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. (PubMed id 7660129)1, 3 Aso T....Conaway R.C. (1995)
- RNA polymerase II transcription factor SIII. I. Identification, purification, and properties. (PubMed id 8244996)1, 3 Bradsher J.N....Conaway J.W. (1993)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. (PubMed id 11932239)9 Strichman-Almashanu L.Z....Feinberg A.P. (2002)
|
External Searches for TCEB3B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TCEB3B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCEB3B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCEB3B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TCEB3B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TCEB3B gene:
Search GeneIP for patents involving TCEB3B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCEB3B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEB3B |
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