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TCEB3 Gene

protein-coding   GIFtS: 60
GCID: GC01P024069

Transcription Elongation Factor B (SIII), Polypeptide 3...

(Previous names: transcription elongation factor B (SIII), polypeptide 3...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa,
Elongin A)1 2
     SIII2
Elongin 110 KDa Subunit2 3     TCEB3A2
EloA2 3     elongin-A2
RNA Polymerase II Transcription Factor SIII Subunit A12 3     Transcription Elongation Factor B Alpha Subunit2
SIII P1102 3     Transcription Elongation Factor B Polypeptide 32
Transcription Elongation Factor B (SIII), Polypeptide 3 (110kD, Elongin A)1     Elongin-A3

External Ids:    HGNC: 116201   Entrez Gene: 69242   Ensembl: ENSG000000110077   OMIM: 6007865   UniProtKB: Q142413   

Export aliases for TCEB3 gene to outside databases

Previous GC identifers: GC01P023627 GC01P023140 GC01P023539 GC01P023816 GC01P023942 GC01P022327


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCEB3 Gene:
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII
complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing
transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the
transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin
A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The
von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription
elongation. (provided by RefSeq, Jul 2008)

GeneCards Summary for TCEB3 Gene:
TCEB3 (transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)) is a protein-coding gene. An important paralog of this gene is TCEB3CL.

UniProtKB/Swiss-Prot: ELOA1_HUMAN, Q14241
Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA
polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally
active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII
regulatory subunits B and C (elongin BC complex)

Gene Wiki entry for TCEB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCEB3 gene promoter:
         STAT1   Pax-5   STAT1beta   Pax-2   Pax-2a   IRF-1   FOXJ2 (long isoform)   c-Myb   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCEB3 promoter sequence
   Search Chromatin IP Primers for TCEB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCEB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.1

TCEB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEB3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P024069:  view genomic region     (about GC identifiers)

Start:
24,069,645 bp from pter      End:
24,088,549 bp from pter
Size:
18,905 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ELOA1_HUMAN, Q14241 (See protein sequence)
Recommended Name: Transcription elongation factor B polypeptide 3  
Size: 798 amino acids; 89909 Da
Subunit: Heterotrimer of an A (A1, A2 or A3), B and C subunit. The C subunit mediates the binding of the elongin
BC complex to subunit A (By similarity)
Caution: It is uncertain whether Met-1 or Met-27 is the initiator
Sequence caution: Sequence=AAA75492.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH02883.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAO15305.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG35905.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=CAB40157.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=EAW95070.1; Type=Erroneous initiation; Note=Translation
N-terminally extended;
1 PDB 3D structure from and Proteopedia for TCEB3:
4HFX (3D)    
Secondary accessions: B2R7Q8 Q8IXH1

Explore the universe of human proteins at neXtProt for TCEB3: NX_Q14241

Explore proteomics data for TCEB3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TCEB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003189.2  
    ENSEMBL proteins: 
     ENSP00000395574   ENSP00000476781  
    Reactome Protein details: Q14241

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for TCEB3 (4 products) 

     
    antibodies-online peptides for TCEB3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001810 F-box_dom
     IPR003617 TFIIS/CRSP70_N_sub
     IPR010684 RNA_pol_II_trans_fac_SIII_A
     IPR017923 TFIIS_N

    Graphical View of Domain Structure for InterPro Entry Q14241

    ProtoNet protein and cluster: Q14241

    2 Blocks protein domains:
    IPB003617 Transcription elongation factor S-II
    IPB010684 RNA polymerase II transcription factor SIII subunit A


    UniProtKB/Swiss-Prot: ELOA1_HUMAN, Q14241
    Domain: The elongin BC complex binding domain is also known as BC-box with the consensus
    [APST]-L-x(3)-C-x(3)-[AILV]
    Similarity: Contains 1 F-box domain
    Similarity: Contains 1 TFIIS N-terminal domain


    Find genes that share domains with TCEB3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELOA1_HUMAN, Q14241
    Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA
    polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally
    active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII
    regulatory subunits B and C (elongin BC complex)

         Genatlas biochemistry entry for TCEB3:
    elongin A,110kDa,catalyzing subunit of the transcription elongation factor B complex SIII,polypeptide 3,also
    including TCEB1 and TCEB2 (elongin C,B,see symbols) increasing the average rate of RNA chain elongation across
    DNA templates

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TCEB3           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for TCEB3:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Increased cell number in G1, s  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tceb3):
     cardiovascular system  cellular  embryogenesis  growth/size/body  integument 
     liver/biliary system  mortality/aging  nervous system 

    Find genes that share phenotypes with TCEB3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tceb3tm1Aso for TCEB3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCEB3
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    miRTarBase miRNAs that target TCEB3:
    hsa-mir-193b-3p (MIRT041516), hsa-mir-192-5p (MIRT026940), hsa-let-7f-5p (MIRT051374), hsa-mir-484 (MIRT041964), hsa-mir-215-5p (MIRT024881), hsa-mir-320b (MIRT036200)

    Block miRNA regulation of human, mouse, rat TCEB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TCEB3 (see all 85):
    hsa-miR-548j hsa-miR-642a hsa-miR-520e hsa-miR-106a hsa-miR-3122 hsa-miR-149 hsa-miR-93 hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmidTCEB3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ELOA1_HUMAN, Q14241: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TCEB3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TCEB3 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript0.77
    Pausing and recovery of HIV elongation0.73
    HIV Transcription Elongation0.77
    HIV elongation arrest and recovery0.73
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.77
    Pausing and recovery of Tat-mediated HIV elongation0.72
    RNA Polymerase II Transcription Elongation0.75
    Tat-mediated HIV elongation arrest and recovery0.72
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    3Gene Expression
    Gene Expression0.40
    4Disease
    Disease
    5Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with TCEB3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TCEB3
        Chromatin Regulation / Acetylation

    Selected Reactome Pathways for TCEB3 (see all 10)
        Pausing and recovery of Tat-mediated HIV elongation
    Formation of RNA Pol II elongation complex
    Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    Pausing and recovery of HIV elongation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCEB3
    Interactions:

        GeneGlobe Interaction Network for TCEB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TCEB3 (Q142412, 3 ENSP000003955744) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NINLQ9Y2I62, 3, ENSP000002788864MINT-66256 I2D: score=5 STRING: ENSP00000278886
    CUL5Q930342, 3MINT-7277713 I2D: score=1 
    RAP1AP628343, ENSP000003487864I2D: score=3 STRING: ENSP00000348786
    TCEB2Q153703, ENSP000002623064I2D: score=3 STRING: ENSP00000262306
    MED21Q135033, ENSP000002828924I2D: score=2 STRING: ENSP00000282892
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS7660129
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--

    Find genes that share ontologies with TCEB3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for TCEB3 (ELOA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TCEB3 gene: 
    NM_003198.2  

    Unigene Cluster for TCEB3:

    Transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
    Hs.15535  [show with all ESTs]
    Unigene Representative Sequence: NM_003198
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418390(uc001bho.3) ENST00000609199 ENST00000487554
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    hsa-miR-548j hsa-miR-642a hsa-miR-520e hsa-miR-106a hsa-miR-3122 hsa-miR-149 hsa-miR-93 hsa-miR-637
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      QuantiFast Probe-based Assays in human, mouse, rat TCEB3

    Additional mRNA sequence: 

    AF070554.1 AF116729.1 AK124839.1 AK310229.1 AK313079.1 BC002883.2 BC020448.1 L47345.1 

    14 DOTS entries:

    DT.315546  DT.101978967  DT.214029  DT.91958670  DT.100751968  DT.92434738  DT.121456998  DT.121456990 
    DT.121457054  DT.92434737  DT.95170957  DT.100032566  DT.121456983  DT.91656721 

    1 AceView cDNA sequence:

    BC019949 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TCEB3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -                                                                           
    SP2:                                                                                          
    SP3:              -     -     -                                                               


    ECgene alternative splicing isoforms for TCEB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCEB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTAAATAAA
    TCEB3 Expression
    About this image


    TCEB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    TCEB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCEB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.15535
        Custom PCR Arrays for TCEB3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TCEB3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tceb31 , 5 transcription elongation factor B (SIII), polypeptide more1, 5 82.7(n)1
    82.14(a)1
      4 (68.34 cM)5
    272241  NM_013736.41  NP_038764.21 
     1360033685 
    chicken
    (Gallus gallus)
    Aves TCEB31 transcription elongation factor B (SIII), polypeptide more 64.68(n)
    61.9(a)
      419683  NM_001030905.1  NP_001026076.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    55(a)
    1 → many
    GL343498.1(149248-165168)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.131622 Xenopus laevis transcribed sequence with weak similarity more 76.07(n)    BJ095462.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.2062 Danio rerio cDNA clone MGC55573 IMAGE2643182, complete more 72.94(n)    BC044429.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67553 transcription elongation factor 32(a)   94E9   --
    worm
    (Caenorhabditis elegans)
    Secernentea R03D7.46
    Protein R03D7.4 (R03D7.4) mRNA, complete cds
    22(a)
    1 → many
    II(10943391-10945660) WBGene00010990


    ENSEMBL Gene Tree for TCEB3 (if available)
    TreeFam Gene Tree for TCEB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCEB3 gene
    TCEB3CL2  TCEB3B2  TCEB3CL22  TCEB3C2  
    2 SIMAP similar genes for TCEB3 using alignment to 1 protein entry:     ELOA1_HUMAN:
    TCEA2    TCEB3B

    Find genes that share paralogs with TCEB3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TCEB3
    PGOHUM00000259799


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCEB3 (see all 423)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2016373061,2
    C--24067929(+) TTCTG-/TTTTTT 1 -- us2k10--------
    rs1896893091,2
    --24068019(+) CAAATG/TGTTCT 1 -- us2k10--------
    rs617773471,2
    C--24068184(+) CCCCAA/CAGTGC 1 -- us2k14Minor allele frequency- C:0.35NA WA EA 360
    rs1506836811,2
    --24068328(+) TCTGCC/TTCAAG 1 -- us2k10--------
    rs796465311,2
    C,F--24068519(+) TGGATG/AGTCAT 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs22679601,2
    C,F,A,H--24068544(+) CTTTAC/TATCCA 1 -- us2k122Minor allele frequency- T:0.47EA NS NA WA CSA 3844
    rs770745691,2
    C,F--24068711(+) GGGAGG/TGGCGC 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1399978291,2
    C--24068714(+) AGGGGC/TGCCAA 1 -- us2k10--------
    rs1151324451,2
    C,F--24068721(+) CCAAAT/CGGAGG 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs791552431,2
    C,F--24068741(+) ATGGTA/GGAGAG 1 -- us2k11Minor allele frequency- G:0.07WA 118

    HapMap Linkage Disequilibrium report for TCEB3 (24069645 - 24088549 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TCEB3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCEB3
    DNA2.0 Custom Variant and Variant Library Synthesis for TCEB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600786    OMIM disorders: --


    Find genes that share disorders with TCEB3           About GenesLikeMe

    1 Novoseek inferred disease relationship for TCEB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 11.3 9 8896449 (2), 14528910 (1), 8810329 (1), 10430890 (1) (see all 5)

    Genetic Association Database (GAD): TCEB3
    Human Genome Epidemiology (HuGE) Navigator: TCEB3 (2 documents)

    Export disorders for TCEB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCEB3 gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with TCEB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. (PubMed id 7660129)1, 3, 9 Aso T....Conaway R.C. (Science 1995)
    2. A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin. (PubMed id 8654961)1, 2, 9 Aso T....Conaway R.C. (Gene 1996)
    3. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Assignment of a human gene encoding the 110-kDa subunit of general transcription factor elongin (SIII) to chromosome 1p36.1. (PubMed id 8586449)1, 3 Aso T....Conaway J.W. (Genomics 1995)
    8. Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain. (PubMed id 12943681)1, 9 Tamura K.... Aso T. (Biochem. Biophys. Res. Commun. 2003)
    9. Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators. (PubMed id 9305922)1, 9 Pan G....Greenblatt J. (J. Biol. Chem. 1997)
    10. Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis. (PubMed id 10692460)1, 9 Aso T.... Hatakeyama M. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6924 HGNC: 11620 AceView: TCEB3 Ensembl:ENSG00000011007 euGenes: HUgn6924
    ECgene: TCEB3 H-InvDB: TCEB3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCEB3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TCEB3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCEB3 gene:
    Search GeneIP for patents involving TCEB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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