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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCEB3 Gene

protein-coding   GIFtS: 56
GCID: GC01P024069

transcription elongation factor B (SIII), polypeptide 3...

(Previous names: transcription elongation factor B (SIII), polypeptide 3...)
 Explore 3 diseases affiliated with
TCEB3 via our new
 Human Malady Compendium 
Biological research products
for TCEB3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin
A)1 2
     SIII P1102 3
SIII1 2     Transcription Elongation Factor B (SIII), Polypeptide 3 (110kD, Elongin A)1
TCEB3A1 2     Elongin-A3
Elongin 110 KDa Subunit2 3     Transcription Elongation Factor B Alpha Subunit2
EloA2 3     Transcription Elongation Factor B Polypeptide 32
RNA Polymerase II Transcription Factor SIII Subunit A12 3     Elongin-A3

External Ids:    HGNC: 116201   Entrez Gene: 69242   Ensembl: ENSG000000110077   OMIM: 6007865   UniProtKB: Q142413   

Export aliases for TCEB3 gene to outside databases

Previous GC identifers: GC01P023627 GC01P023140 GC01P023539 GC01P023816 GC01P023942 GC01P022327


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCEB3:
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII
complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient
pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally
active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically
expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor
suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: ELOA1_HUMAN, Q14241
Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase
II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its
transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C
(elongin BC complex)

Gene Wiki entry for TCEB3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCEB3 gene promoter:
         STAT1   Pax-5   STAT1beta   Pax-2   Pax-2a   IRF-1   FOXJ2 (long isoform)   c-Myb   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCEB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TCEB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.1

TCEB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEB3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P024069:  view genomic region     (about GC identifiers)

Start:
24,069,645 bp from pter      End:
24,088,549 bp from pter
Size:
18,905 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ELOA1_HUMAN, Q14241 (See protein sequence)
Recommended Name: Transcription elongation factor B polypeptide 3  
Size: 798 amino acids; 89909 Da
Subunit: Heterotrimer of an A (A1, A2 or A3), B and C subunit. The C subunit mediates the binding of the elongin BC
complex to subunit A (By similarity)
Subcellular location: Nucleus (Probable)
Caution: It is uncertain whether Met-1 or Met-27 is the initiator
Sequence caution: Sequence=AAA75492.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH02883.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAO15305.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG35905.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=CAB40157.1; Type=Erroneous initiation; Note=Translation N-terminally
extended; Sequence=EAW95070.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for TCEB3:
4HFX (3D)    
Secondary accessions: B2R7Q8 Q8IXH1

Explore the universe of human proteins at neXtProt for TCEB3: NX_Q14241

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14241

  • TCEB3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003189.2  
    ENSEMBL proteins: 
     ENSP00000395574  
    Reactome Protein details: Q14241
    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0008023transcription elongation factor complex ----
    GO:0016021integral to membrane IEA--


    TCEB3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TCEB3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001810 F-box_dom_cyclin-like
     IPR003617 TFIIS/CRSP70_N_sub
     IPR010684 RNA_pol_II_trans_fac_SIII_A
     IPR017923 TFIIS_N

    Graphical View of Domain Structure for InterPro Entry Q14241

    ProtoNet protein and cluster: Q14241

    2 Blocks protein families:
    IPB003617 Transcription elongation factor S-II
    IPB010684 RNA polymerase II transcription factor SIII subunit A


    UniProtKB/Swiss-Prot: ELOA1_HUMAN, Q14241
    Domain: The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]
    Similarity: Contains 1 F-box domain
    Similarity: Contains 1 TFIIS N-terminal domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ELOA1_HUMAN, Q14241
    Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase
    II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its
    transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C
    (elongin BC complex)

         Genatlas biochemistry entry for TCEB3:
    elongin A,110kDa,catalyzing subunit of the transcription elongation factor B complex SIII,polypeptide 3,also including
    TCEB1 and TCEB2 (elongin C,B,see symbols) increasing the average rate of RNA chain elongation across DNA templates

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    hsa-miR-548j hsa-miR-642a hsa-miR-520e hsa-miR-106a hsa-miR-3122 hsa-miR-149 hsa-miR-93 hsa-miR-637
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0016944RNA polymerase II transcription elongation factor activity ----


    TCEB3 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for TCEB3:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Increased cell number in G1, s  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Tceb3tm1Aso for TCEB3
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tceb3):
     cardiovascular system  cellular  embryogenesis  growth/size  integument 
     liver/biliary system  mortality/aging  nervous system 

    TCEB3 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Formation of RNA Pol II elongation complex
    8/13 pathways (see all 13)
    RNA Polymerase II Transcription Elongation1.00
    Pausing and recovery of HIV-1 elongation0.74
    Formation of HIV-1 elongation complex in the absence of HIV-1 Tat1.00
    Elongation arrest and recovery0.74
    Formation of RNA Pol II elongation complex 1.00
    RNA Polymerase II Pre-transcription Events0.72
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.98
    Tat-mediated HIV-1 elongation arrest and recovery 0.71
    2Late Phase of HIV Life Cycle
    Late Phase of HIV Life Cycle1.00
    HIV Life Cycle0.90
    3Transcription
    Transcription1.00
    RNA Polymerase II Transcription0.69
    4HIV Infection
    HIV Infection1.00
    5Disease
    Disease1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TCEB3
        Chromatin Regulation / Acetylation

    5/20        Reactome Pathways for TCEB3 (see all 20)
        Formation of RNA Pol II elongation complex
    Pausing and recovery of Tat-mediated HIV-1 elongation
    Tat-mediated HIV-1 elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    Late Phase of HIV Life Cycle



    TCEB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCEB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/74 Interacting proteins for TCEB3 (Q142412, 3 ENSP000003955744) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NINLQ9Y2I62, 3, ENSP000002788864MINT-66256 I2D: score=5 STRING: ENSP00000278886
    CUL5Q930342, 3MINT-7277713 I2D: score=1 
    RAP1AP628343, ENSP000003487864I2D: score=3 STRING: ENSP00000348786
    TCEB2Q153703, ENSP000002623064I2D: score=3 STRING: ENSP00000262306
    MED21Q135033, ENSP000002828924I2D: score=2 STRING: ENSP00000282892
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS7660129
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0016032viral reproduction TAS--


    TCEB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about TCEB3 / ELOA1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCEB3 gene: 
    NM_003198.2  

    Unigene Cluster for TCEB3:

    Transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
    Hs.15535  [show with all ESTs]
    Unigene Representative Sequence: NM_003198
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418390(uc001bho.3) ENST00000487554

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    hsa-miR-548j hsa-miR-642a hsa-miR-520e hsa-miR-106a hsa-miR-3122 hsa-miR-149 hsa-miR-93 hsa-miR-637
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    Additional cDNA sequence: 

    AF070554.1 AF116729.1 AK124839.1 AK310229.1 AK313079.1 BC002883.2 BC020448.1 L47345.1 

    14 DOTS entries:

    DT.315546  DT.101978967  DT.214029  DT.91958670  DT.100751968  DT.92434738  DT.121456998  DT.121456990 
    DT.121457054  DT.92434737  DT.95170957  DT.100032566  DT.121456983  DT.91656721 

    1 AceView cDNA sequence:

    BC019949 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TCEB3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -                                                                           
    SP2:                                                                                          
    SP3:              -     -     -                                                               


    ECgene alternative splicing isoforms for TCEB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCEB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTAAATAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TCEB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCEB3

    SOURCE GeneReport for Unigene cluster: Hs.15535
        SABiosciences Custom PCR Arrays for TCEB3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TCEB3 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TCEB31 transcription elongation factor B (SIII), polypeptide more 64.68(n)
    61.9(a)
      419683  NM_001030905.1  NP_001026076.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    58(a)
    1 → many
    GL343498.1(149248-165168)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.131622 Xenopus laevis transcribed sequence with weak similarity more 76.07(n)    BJ095462.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.2062 Danio rerio cDNA clone MGC55573 IMAGE2643182, complete more 72.94(n)    BC044429.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67553
    EloA1
    transcription elongation factor3
    Elongin A1
    32(a)3
    45.14(n)1
    34.46(a)1
      94E93
    427491  NM_170061.21  NP_732846.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R03D7.46
    Transcription elongation factor B polypeptide 3
    24(a)
    1 → many
    II(10943331-10945600)


    ENSEMBL Gene Tree for TCEB3 (if available)
    TreeFam Gene Tree for TCEB3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCEB3 gene
    TCEB3B2  TCEB3CL2  TCEB3CL22  TCEB3C2  
    2 SIMAP similar genes for TCEB3 using alignment to 1 protein entry:     ELOA1_HUMAN:
    TCEA2    TCEB3B

    TCEB3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TCEB3
    PGOHUM00000259799


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/363 NCBI SNPs in TCEB3 are shown (see all 363    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2016373061,2
    --24067929(+) TTCTG-/TTTTTT 1 -- us2k10--------
    rs1896893091,2
    --24068019(+) CAAATG/TGTTCT 1 -- us2k10--------
    rs617773471,2
    C,--24068184(+) CCCCAA/CAGTGC 1 -- us2k14Minor allele frequency- C:0.35NA WA EA 360
    rs1506836811,2
    --24068328(+) TCTGCC/TTCAAG 1 -- us2k10--------
    rs796465311,2
    F,--24068519(+) TGGATG/AGTCAT 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs22679601,2
    C,F,A,H,--24068544(+) CTTTAC/TATCCA 1 -- us2k122Minor allele frequency- T:0.47EA NS NA WA CSA 3844
    rs770745691,2
    C,F,--24068711(+) GGGAGG/TGGCGC 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1399978291,2
    --24068714(+) AGGGGC/TGCCAA 1 -- us2k10--------
    rs1151324451,2
    F,--24068721(+) CCAAAT/CGGAGG 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs791552431,2
    C,F,--24068741(+) ATGGTA/GGAGAG 1 -- us2k11Minor allele frequency- G:0.07WA 118

    HapMap Linkage Disequilibrium report for TCEB3 (24069645 - 24088549 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TCEB3: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TCEB3 for disorders           About GeneDecksing

    OMIM gene information: 600786    OMIM disorders: --

    3 diseases for TCEB3:    About MalaCards
    down syndrome    lung cancer    thyroiditis

    1 Novoseek disease relationship for TCEB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 11.3 9 8896449 (2), 14528910 (1), 8810329 (1), 10430890 (1) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: TCEB3 (2 documents)

    Export disorders for TCEB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCEB3 gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with TCEB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. (PubMed id 7660129)1, 3, 9 Aso T....Conaway R.C. (1995)
    2. A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin. (PubMed id 8654961)1, 2, 9 Aso T....Conaway R.C. (1996)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Assignment of a human gene encoding the 110-kDa subunit of general transcription factor elongin (SIII) to chromosome 1p36.1. (PubMed id 8586449)1, 3 Aso T....Conaway J.W. (1995)
    7. Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain. (PubMed id 12943681)1, 9 Tamura K.... Aso T. (2003)
    8. Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators. (PubMed id 9305922)1, 9 Pan G....Greenblatt J. (1997)
    9. Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis. (PubMed id 10692460)1, 9 Aso T.... Hatakeyama M. (2000)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6924 HGNC: 11620 AceView: TCEB3 Ensembl:ENSG00000011007 euGenes: HUgn6924
    ECgene: TCEB3 H-InvDB: TCEB3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCEB3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TCEB3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCEB3 gene:
    Search GeneIP for patents involving TCEB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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