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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCEB3 Gene

protein-coding   GIFtS: 60
GCID: GC01P024069

Transcription Elongation Factor B (SIII), Polypeptide 3...

(Previous names: transcription elongation factor B (SIII), polypeptide 3...)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa,
Elongin A)1 2
     SIII2
Elongin 110 KDa Subunit2 3     TCEB3A2
EloA2 3     elongin-A2
RNA Polymerase II Transcription Factor SIII Subunit A12 3     Transcription Elongation Factor B Alpha Subunit2
SIII P1102 3     Transcription Elongation Factor B Polypeptide 32
Transcription Elongation Factor B (SIII), Polypeptide 3 (110kD, Elongin A)1     Elongin-A3

External Ids:    HGNC: 116201   Entrez Gene: 69242   Ensembl: ENSG000000110077   OMIM: 6007865   UniProtKB: Q142413   

Export aliases for TCEB3 gene to outside databases

Previous GC identifers: GC01P023627 GC01P023140 GC01P023539 GC01P023816 GC01P023942 GC01P022327


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCEB3 Gene:
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII
complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing
transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the
transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin
A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The
von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription
elongation. (provided by RefSeq, Jul 2008)

GeneCards Summary for TCEB3 Gene: 
TCEB3 (transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)) is a protein-coding gene. Diseases associated with TCEB3 include down syndrome, and lung cancer, and among its related super-pathways are Formation of the Early Elongation Complex and HIV Life Cycle. GO annotations related to this gene include DNA binding. An important paralog of this gene is TCEB3CL.

UniProtKB/Swiss-Prot: ELOA1_HUMAN, Q14241
Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA
polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally
active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII
regulatory subunits B and C (elongin BC complex)

Gene Wiki entry for TCEB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCEB3 gene promoter:
         STAT1   Pax-5   STAT1beta   Pax-2   Pax-2a   IRF-1   FOXJ2 (long isoform)   c-Myb   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCEB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TCEB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.1

TCEB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEB3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P024069:  view genomic region     (about GC identifiers)

Start:
24,069,645 bp from pter      End:
24,088,549 bp from pter
Size:
18,905 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ELOA1_HUMAN, Q14241 (See protein sequence)
Recommended Name: Transcription elongation factor B polypeptide 3  
Size: 798 amino acids; 89909 Da
Subunit: Heterotrimer of an A (A1, A2 or A3), B and C subunit. The C subunit mediates the binding of the elongin
BC complex to subunit A (By similarity)
Subcellular location: Nucleus (Probable)
Caution: It is uncertain whether Met-1 or Met-27 is the initiator
Sequence caution: Sequence=AAA75492.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH02883.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAO15305.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG35905.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=CAB40157.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=EAW95070.1; Type=Erroneous initiation; Note=Translation
N-terminally extended;
1 PDB 3D structure from and Proteopedia for TCEB3:
4HFX (3D)    
Secondary accessions: B2R7Q8 Q8IXH1

Explore the universe of human proteins at neXtProt for TCEB3: NX_Q14241

Explore proteomics data for TCEB3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14241

  • TCEB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCEB3 Protein Expression
    REFSEQ proteins: NP_003189.2  
    ENSEMBL proteins: 
     ENSP00000395574  
    Reactome Protein details: Q14241
    Human Recombinant Protein Products for TCEB3: 
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    Novus Biologicals TCEB3 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0016021integral to membrane IEA--

    TCEB3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001810 F-box_dom_cyclin-like
     IPR003617 TFIIS/CRSP70_N_sub
     IPR010684 RNA_pol_II_trans_fac_SIII_A
     IPR017923 TFIIS_N

    Graphical View of Domain Structure for InterPro Entry Q14241

    ProtoNet protein and cluster: Q14241

    2 Blocks protein domains:
    IPB003617 Transcription elongation factor S-II
    IPB010684 RNA polymerase II transcription factor SIII subunit A


    UniProtKB/Swiss-Prot: ELOA1_HUMAN, Q14241
    Domain: The elongin BC complex binding domain is also known as BC-box with the consensus
    [APST]-L-x(3)-C-x(3)-[AILV]
    Similarity: Contains 1 F-box domain
    Similarity: Contains 1 TFIIS N-terminal domain


    TCEB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELOA1_HUMAN, Q14241
    Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA
    polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally
    active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII
    regulatory subunits B and C (elongin BC complex)

         Genatlas biochemistry entry for TCEB3:
    elongin A,110kDa,catalyzing subunit of the transcription elongation factor B complex SIII,polypeptide 3,also
    including TCEB1 and TCEB2 (elongin C,B,see symbols) increasing the average rate of RNA chain elongation across
    DNA templates

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
         
    TCEB3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TCEB3:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Increased cell number in G1, s  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tceb3):
     cardiovascular system  cellular  embryogenesis  growth/size  integument 
     liver/biliary system  mortality/aging  nervous system 

    TCEB3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tceb3tm1Aso for TCEB3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TCEB3 
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    SwitchGear 3'UTR luciferase reporter plasmidTCEB3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TCEB3 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript0.78
    HIV elongation arrest and recovery0.74
    HIV Transcription Elongation0.78
    Pausing and recovery of HIV elongation0.74
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.78
    Pausing and recovery of Tat-mediated HIV elongation0.73
    Formation of HIV elongation complex in the absence of HIV Tat0.76
    Tat-mediated HIV elongation arrest and recovery0.73
    2HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    3Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    4Generic Transcription Pathway
    Gene Expression0.47
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TCEB3
        Chromatin Regulation / Acetylation

    5/20        Reactome Pathways for TCEB3 (see all 20)
        Formation of RNA Pol II elongation complex
    Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    Late Phase of HIV Life Cycle



    TCEB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCEB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/74 Interacting proteins for TCEB3 (Q142412, 3 ENSP000003955744) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NINLQ9Y2I62, 3, ENSP000002788864MINT-66256 I2D: score=5 STRING: ENSP00000278886
    CUL5Q930342, 3MINT-7277713 I2D: score=1 
    RAP1AP628343, ENSP000003487864I2D: score=3 STRING: ENSP00000348786
    TCEB2Q153703, ENSP000002623064I2D: score=3 STRING: ENSP00000262306
    MED21Q135033, ENSP000002828924I2D: score=2 STRING: ENSP00000282892
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS7660129
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--

    TCEB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCEB3 (ELOA1)

    Search CenterWatch for drugs/clinical trials and news about TCEB3 / ELOA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCEB3 gene: 
    NM_003198.2  

    Unigene Cluster for TCEB3:

    Transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
    Hs.15535  [show with all ESTs]
    Unigene Representative Sequence: NM_003198
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418390(uc001bho.3) ENST00000487554
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    hsa-miR-548j hsa-miR-642a hsa-miR-520e hsa-miR-106a hsa-miR-3122 hsa-miR-149 hsa-miR-93 hsa-miR-637
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    Additional mRNA sequence: 

    AF070554.1 AF116729.1 AK124839.1 AK310229.1 AK313079.1 BC002883.2 BC020448.1 L47345.1 

    14 DOTS entries:

    DT.315546  DT.101978967  DT.214029  DT.91958670  DT.100751968  DT.92434738  DT.121456998  DT.121456990 
    DT.121457054  DT.92434737  DT.95170957  DT.100032566  DT.121456983  DT.91656721 

    1 AceView cDNA sequence:

    BC019949 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TCEB3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -                                                                           
    SP2:                                                                                          
    SP3:              -     -     -                                                               


    ECgene alternative splicing isoforms for TCEB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCEB3 expression in normal human tissues (normalized intensities)      TCEB3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTAAATAAA
    TCEB3 Expression
    About this image


    TCEB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             lung ; pneumocytes   

    See TCEB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCEB3

    SOURCE GeneReport for Unigene cluster: Hs.15535
        SABiosciences Custom PCR Arrays for TCEB3
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TCEB3 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tceb31 , 5 transcription elongation factor B (SIII), polypeptide more1, 5 83.75(n)1
    83.44(a)1
      4 (68.34 cM)5
    272241  NM_013736.41  NP_038764.21 
     1360033685 
    chicken
    (Gallus gallus)
    Aves TCEB31 transcription elongation factor B (SIII), polypeptide more 64.68(n)
    61.9(a)
      419683  NM_001030905.1  NP_001026076.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    51(a)
    1 → many
    GL343498.1(149248-165168)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.131622 Xenopus laevis transcribed sequence with weak similarity more 76.07(n)    BJ095462.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.2062 Danio rerio cDNA clone MGC55573 IMAGE2643182, complete more 72.94(n)    BC044429.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67553
    EloA1
    transcription elongation factor3
    Elongin A1
    32(a)3
    45.14(n)1
    34.46(a)1
      94E93
    427491  NM_170061.21  NP_732846.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R03D7.46
    Transcription elongation factor B polypeptide 3
    22(a)
    1 → many
    II(10943391-10945660)


    ENSEMBL Gene Tree for TCEB3 (if available)
    TreeFam Gene Tree for TCEB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCEB3 gene
    TCEB3CL2  TCEB3B2  TCEB3CL22  TCEB3C2  
    2 SIMAP similar genes for TCEB3 using alignment to 1 protein entry:     ELOA1_HUMAN:
    TCEA2    TCEB3B

    TCEB3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TCEB3
    PGOHUM00000259799


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/423 SNPs in TCEB3 are shown (see all 423)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2016373061,2
    C--24067929(+) TTCTG-/TTTTTT 1 -- us2k10--------
    rs1896893091,2
    --24068019(+) CAAATG/TGTTCT 1 -- us2k10--------
    rs617773471,2
    C--24068184(+) CCCCAA/CAGTGC 1 -- us2k14Minor allele frequency- C:0.35NA WA EA 360
    rs1506836811,2
    --24068328(+) TCTGCC/TTCAAG 1 -- us2k10--------
    rs796465311,2
    C,F--24068519(+) TGGATG/AGTCAT 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs22679601,2
    C,F,A,H--24068544(+) CTTTAC/TATCCA 1 -- us2k122Minor allele frequency- T:0.47EA NS NA WA CSA 3844
    rs770745691,2
    C,F--24068711(+) GGGAGG/TGGCGC 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1399978291,2
    C--24068714(+) AGGGGC/TGCCAA 1 -- us2k10--------
    rs1151324451,2
    C,F--24068721(+) CCAAAT/CGGAGG 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs791552431,2
    C,F--24068741(+) ATGGTA/GGAGAG 1 -- us2k11Minor allele frequency- G:0.07WA 118

    HapMap Linkage Disequilibrium report for TCEB3 (24069645 - 24088549 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TCEB3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TCEB3
    DNA2.0 Custom Variant and Variant Library Synthesis for TCEB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600786    OMIM disorders: --

    4 diseases for TCEB3:    About MalaCards
    down syndrome    lung cancer    thyroiditis    endotheliitis


    TCEB3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TCEB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 11.3 9 8896449 (2), 14528910 (1), 8810329 (1), 10430890 (1) (see all 5)

    Genetic Association Database (GAD): TCEB3
    Human Genome Epidemiology (HuGE) Navigator: TCEB3 (2 documents)

    Export disorders for TCEB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCEB3 gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with TCEB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. (PubMed id 7660129)1, 3, 9 Aso T....Conaway R.C. (1995)
    2. A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin. (PubMed id 8654961)1, 2, 9 Aso T....Conaway R.C. (1996)
    3. The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683)1, 4 Landa I....Robledo M. (2009)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Assignment of a human gene encoding the 110-kDa subunit of general transcription factor elongin (SIII) to chromosome 1p36.1. (PubMed id 8586449)1, 3 Aso T....Conaway J.W. (1995)
    8. Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain. (PubMed id 12943681)1, 9 Tamura K.... Aso T. (2003)
    9. Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators. (PubMed id 9305922)1, 9 Pan G....Greenblatt J. (1997)
    10. Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis. (PubMed id 10692460)1, 9 Aso T.... Hatakeyama M. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6924 HGNC: 11620 AceView: TCEB3 Ensembl:ENSG00000011007 euGenes: HUgn6924
    ECgene: TCEB3 H-InvDB: TCEB3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCEB3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TCEB3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCEB3 gene:
    Search GeneIP for patents involving TCEB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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