Aliases for TCEB3 Gene
External Ids for TCEB3 Gene
Previous GeneCards Identifiers for TCEB3 Gene
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]
GeneCards Summary for TCEB3 Gene
TCEB3 (Transcription Elongation Factor B Subunit 3) is a Protein Coding gene. Diseases associated with TCEB3 include Renal Cell Carcinoma, Papillary. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Formation of the HIV-1 Early Elongation Complex. An important paralog of this gene is TCEB3B.
UniProtKB/Swiss-Prot for TCEB3 Gene
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).