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Aliases for TCEB3 Gene

Aliases for TCEB3 Gene

  • Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A) 2 3
  • RNA Polymerase II Transcription Factor SIII Subunit A1 3 4
  • Elongin 110 KDa Subunit 3 4
  • SIII P110 3 4
  • Elongin-A 3 4
  • EloA 3 4
  • Transcription Elongation Factor B (SIII), Polypeptide 3 (110kD, Elongin A) 2
  • Transcription Elongation Factor B Alpha Subunit 3
  • TCEB3A 3
  • SIII 3

External Ids for TCEB3 Gene

Previous GeneCards Identifiers for TCEB3 Gene

  • GC01P023627
  • GC01P023140
  • GC01P023539
  • GC01P023816
  • GC01P023942
  • GC01P024069
  • GC01P022327

Summaries for TCEB3 Gene

Entrez Gene Summary for TCEB3 Gene

  • This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEB3 Gene

TCEB3 (Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A)) is a Protein Coding gene. Among its related pathways are Infectious disease and Gene Expression. An important paralog of this gene is TCEB3B.

UniProtKB/Swiss-Prot for TCEB3 Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)

Gene Wiki entry for TCEB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEB3 Gene

Genomics for TCEB3 Gene

Regulatory Elements for TCEB3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TCEB3 Gene

Chromosome:
1
Start:
23,743,155 bp from pter
End:
23,762,059 bp from pter
Size:
18,905 bases
Orientation:
Plus strand

Genomic View for TCEB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEB3 Gene

Proteins for TCEB3 Gene

  • Protein details for TCEB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14241-ELOA1_HUMAN
    Recommended name:
    Transcription elongation factor B polypeptide 3
    Protein Accession:
    Q14241
    Secondary Accessions:
    • B2R7Q8
    • Q8IXH1

    Protein attributes for TCEB3 Gene

    Size:
    798 amino acids
    Molecular mass:
    89909 Da
    Quaternary structure:
    • Heterotrimer of an A (A1, A2 or A3), B and C subunit. The C subunit mediates the binding of the elongin BC complex to subunit A (By similarity).
    SequenceCaution:
    • Sequence=AAA75492.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH02883.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO15305.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG35905.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB40157.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW95070.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TCEB3 Gene

neXtProt entry for TCEB3 Gene

Proteomics data for TCEB3 Gene at MOPED

Post-translational modifications for TCEB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TCEB3 (TCEB3)

No data available for DME Specific Peptides for TCEB3 Gene

Domains & Families for TCEB3 Gene

Suggested Antigen Peptide Sequences for TCEB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14241

UniProtKB/Swiss-Prot:

ELOA1_HUMAN :
  • The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]
Domain:
  • The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]
  • Contains 1 F-box domain.
  • Contains 1 TFIIS N-terminal domain.
genes like me logo Genes that share domains with TCEB3: view

No data available for Gene Families for TCEB3 Gene

Function for TCEB3 Gene

Molecular function for TCEB3 Gene

GENATLAS Biochemistry:
elongin A,110kDa,catalyzing subunit of the transcription elongation factor B complex SIII,polypeptide 3,also including TCEB1 and TCEB2 (elongin C,B,see symbols) increasing the average rate of RNA chain elongation across DNA templates
UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)

Gene Ontology (GO) - Molecular Function for TCEB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003746 translation elongation factor activity --
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TCEB3: view
genes like me logo Genes that share phenotypes with TCEB3: view

Animal Models for TCEB3 Gene

MGI Knock Outs for TCEB3:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCEB3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TCEB3 Gene

Localization for TCEB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEB3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEB3 Gene COMPARTMENTS Subcellular localization image for TCEB3 gene
Compartment Confidence
extracellular 5
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TCEB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TCEB3: view

Pathways & Interactions for TCEB3 Gene

genes like me logo Genes that share pathways with TCEB3: view

Pathways by source for TCEB3 Gene

1 Cell Signaling Technology pathway for TCEB3 Gene

Gene Ontology (GO) - Biological Process for TCEB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TCEB3: view

No data available for SIGNOR curated interactions for TCEB3 Gene

Drugs & Compounds for TCEB3 Gene

No Compound Related Data Available

Transcripts for TCEB3 Gene

mRNA/cDNA for TCEB3 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCEB3 Gene

Transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCEB3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEB3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:
SP3: - - -

Relevant External Links for TCEB3 Gene

GeneLoc Exon Structure for
TCEB3
ECgene alternative splicing isoforms for
TCEB3

Expression for TCEB3 Gene

mRNA expression in normal human tissues for TCEB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TCEB3 Gene

This gene is overexpressed in Brain (14.3), Peripheral blood mononuclear cells (12.9), Pancreas (11.0), and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCEB3 Gene



SOURCE GeneReport for Unigene cluster for TCEB3 Gene Hs.15535

genes like me logo Genes that share expression patterns with TCEB3: view

Protein tissue co-expression partners for TCEB3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TCEB3 Gene

Orthologs for TCEB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCEB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100851883 35
  • 86.83 (n)
  • 87.27 (a)
TCEB3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCEB3 35
  • 86.76 (n)
  • 84.81 (a)
TCEB3 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tceb3 35
  • 82.7 (n)
  • 82.14 (a)
Tceb3 16
Tceb3 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TCEB3 35
  • 99.25 (n)
  • 98.95 (a)
TCEB3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tceb3 35
  • 82.99 (n)
  • 82.68 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves TCEB3 35
  • 64.68 (n)
  • 61.9 (a)
TCEB3 36
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tceb3 35
  • 59.35 (n)
  • 56.7 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13162 35
zebrafish
(Danio rerio)
Actinopterygii Dr.206 35
zgc:55573 35
  • 58.72 (n)
  • 59.02 (a)
tceb3 36
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6755 37
  • 32 (a)
EloA 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R03D7.4 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for TCEB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCEB3 Gene

ENSEMBL:
Gene Tree for TCEB3 (if available)
TreeFam:
Gene Tree for TCEB3 (if available)

Paralogs for TCEB3 Gene

Paralogs for TCEB3 Gene

(2) SIMAP similar genes for TCEB3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TCEB3 Gene

genes like me logo Genes that share paralogs with TCEB3: view

Variants for TCEB3 Gene

Sequence variations from dbSNP and Humsavar for TCEB3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs520713 - 23,751,497(+) GTGGC(A/C/G/T)TAAAG missense, reference
rs550252 - 23,752,450(+) ACCCG(C/G/T)GATAC reference, missense
rs550850 -- 23,745,865(+) TGGTA(C/T)TAGAC intron-variant
rs557227 -- 23,746,591(+) aacaa(G/T)agcaa intron-variant
rs2076345 -- 23,757,004(+) AGTAG(C/T)ATCAG reference, synonymous-codon

Variation tolerance for TCEB3 Gene

Residual Variation Intolerance Score: 56.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.65; 72.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEB3 Gene

HapMap Linkage Disequilibrium report
TCEB3
Human Gene Mutation Database (HGMD)
TCEB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEB3 Gene

Disorders for TCEB3 Gene

Relevant External Links for TCEB3

Genetic Association Database (GAD)
TCEB3
Human Genome Epidemiology (HuGE) Navigator
TCEB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEB3
genes like me logo Genes that share disorders with TCEB3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEB3 Gene

Publications for TCEB3 Gene

  1. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. (PMID: 7660129) Aso T. … Conaway R.C. (Science 1995) 2 23 67
  2. [DDP-sensitivity-related genes in 10 lung cancer cell lines]. (PMID: 19024514) Li C.H. … Sui G.J. (Zhonghua Zhong Liu Za Zhi 2008) 23 67
  3. Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1. (PMID: 19037258) Yasukawa T. … Aso T. (EMBO J. 2008) 23 67
  4. ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells. (PMID: 17296727) Ribar B. … Prakash S. (Mol. Cell. Biol. 2007) 23 67
  5. Microarray analysis of transcription factor gene expression in melatonin-treated human peripheral blood mononuclear cells. (PMID: 16635017) Ha E. … Baik H.H. (J. Pineal Res. 2006) 23 67

Products for TCEB3 Gene

Sources for TCEB3 Gene

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