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Aliases for TCEB2 Gene

Aliases for TCEB2 Gene

  • Transcription Elongation Factor B Subunit 2 2 3 5
  • Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) 2 3
  • RNA Polymerase II Transcription Factor SIII Subunit B 3 4
  • Elongin 18 KDa Subunit 3 4
  • Elongin-B 3 4
  • SIII P18 3 4
  • ELOB 3 4
  • RNA Polymerase II Transcription Factor SIII P18 Subunit 3
  • Transcription Elongation Factor B Polypeptide 2 3
  • Elongin, 18-KD Subunit 3
  • Elongin B 2
  • SIII 3

External Ids for TCEB2 Gene

Previous GeneCards Identifiers for TCEB2 Gene

  • GC16M002841
  • GC16M002822
  • GC16M002823
  • GC16M002764
  • GC16M002765
  • GC16M002767
  • GC16M002824

Summaries for TCEB2 Gene

Entrez Gene Summary for TCEB2 Gene

  • This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

GeneCards Summary for TCEB2 Gene

TCEB2 (Transcription Elongation Factor B Subunit 2) is a Protein Coding gene. Diseases associated with TCEB2 include Renal Cell Carcinoma and Kidney Cancer. Among its related pathways are Pathways in cancer and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include ubiquitin protein ligase binding and translation elongation factor activity.

UniProtKB/Swiss-Prot for TCEB2 Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

  • The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Gene Wiki entry for TCEB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEB2 Gene

Genomics for TCEB2 Gene

Regulatory Elements for TCEB2 Gene

Enhancers for TCEB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TCEB2 on UCSC Golden Path with GeneCards custom track

Promoters for TCEB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TCEB2 Gene

Chromosome:
16
Start:
2,771,414 bp from pter
End:
2,777,297 bp from pter
Size:
5,884 bases
Orientation:
Minus strand

Genomic View for TCEB2 Gene

Genes around TCEB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEB2 Gene

Proteins for TCEB2 Gene

  • Protein details for TCEB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15370-ELOB_HUMAN
    Recommended name:
    Transcription elongation factor B polypeptide 2
    Protein Accession:
    Q15370
    Secondary Accessions:
    • B7WPD3

    Protein attributes for TCEB2 Gene

    Size:
    118 amino acids
    Molecular mass:
    13133 Da
    Quaternary structure:
    • Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, TCEB3, VHL or WSB1. Substrate adapter protein can be a viral protein such as HIV Vif. Interacts with VHL. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2. Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component.
    SequenceCaution:
    • Sequence=AAC08452.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TCEB2 Gene

    Alternative splice isoforms for TCEB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEB2 Gene

Post-translational modifications for TCEB2 Gene

  • Ubiquitination at Lys 36 and Lys 46
  • Modification sites at PhosphoSitePlus

Other Protein References for TCEB2 Gene

No data available for DME Specific Peptides for TCEB2 Gene

Domains & Families for TCEB2 Gene

Protein Domains for TCEB2 Gene

Suggested Antigen Peptide Sequences for TCEB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15370

UniProtKB/Swiss-Prot:

ELOB_HUMAN :
  • Contains 1 ubiquitin-like domain.
Domain:
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with TCEB2: view

No data available for Gene Families for TCEB2 Gene

Function for TCEB2 Gene

Molecular function for TCEB2 Gene

GENATLAS Biochemistry:
elongin B,18kDa,regulatory subunit of the transcription elongation factor B (SIII),complex SIII,polypeptide 2 (see TCEB3). Also complexing with TCEB2,CUL2 and VHL to form the VCB-CUL2 complex (see VHL)
UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
UniProtKB/Swiss-Prot Function:
The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Gene Ontology (GO) - Molecular Function for TCEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10205047
GO:0031625 ubiquitin protein ligase binding IDA 17636018
genes like me logo Genes that share ontologies with TCEB2: view
genes like me logo Genes that share phenotypes with TCEB2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TCEB2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEB2 Gene

Localization for TCEB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEB2 Gene COMPARTMENTS Subcellular localization image for TCEB2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for TCEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0030891 VCB complex IBA --
GO:0031462 Cul2-RING ubiquitin ligase complex IDA 17636018
GO:0031466 Cul5-RING ubiquitin ligase complex IDA 17636018
genes like me logo Genes that share ontologies with TCEB2: view

Pathways & Interactions for TCEB2 Gene

genes like me logo Genes that share pathways with TCEB2: view

UniProtKB/Swiss-Prot Q15370-ELOB_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TCEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0006461 protein complex assembly TAS 7660129
GO:0016567 protein ubiquitination IEA --
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS --
genes like me logo Genes that share ontologies with TCEB2: view

No data available for SIGNOR curated interactions for TCEB2 Gene

Drugs & Compounds for TCEB2 Gene

(1) Drugs for TCEB2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TCEB2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TCEB2: view

Transcripts for TCEB2 Gene

mRNA/cDNA for TCEB2 Gene

Unigene Clusters for TCEB2 Gene

Transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TCEB2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5
SP1: - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for TCEB2 Gene

GeneLoc Exon Structure for
TCEB2
ECgene alternative splicing isoforms for
TCEB2

Expression for TCEB2 Gene

mRNA expression in normal human tissues for TCEB2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCEB2 Gene



Protein tissue co-expression partners for TCEB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCEB2 Gene:

TCEB2

SOURCE GeneReport for Unigene cluster for TCEB2 Gene:

Hs.172772
genes like me logo Genes that share expression patterns with TCEB2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TCEB2 Gene

Orthologs for TCEB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCEB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TCEB2 34
  • 88.42 (n)
  • 96.61 (a)
-- 35
  • 96 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
-- 35
  • 91 (a)
OneToMany
TCEB2 35
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC479873 34
  • 89.77 (n)
  • 96.49 (a)
TCEB2 35
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TCEB2 34
  • 99.38 (n)
  • 98.14 (a)
-- 35
  • 98 (a)
OneToMany
-- 35
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100909963 34
  • 88.03 (n)
  • 94.02 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tceb2 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCEB2 35
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCEB2 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76322 34
African clawed frog
(Xenopus laevis)
Amphibia tceb2-prov 34
zebrafish
(Danio rerio)
Actinopterygii tceb2 34
tceb2 35
  • 85 (a)
OneToMany
TCEB2 (2 of 2) 35
  • 64 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13460 34
fruit fly
(Drosophila melanogaster)
Insecta Elongin-B 35
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea elb-1 35
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4437 35
  • 55 (a)
OneToOne
Species where no ortholog for TCEB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCEB2 Gene

ENSEMBL:
Gene Tree for TCEB2 (if available)
TreeFam:
Gene Tree for TCEB2 (if available)

Paralogs for TCEB2 Gene

Pseudogenes.org Pseudogenes for TCEB2 Gene

genes like me logo Genes that share paralogs with TCEB2: view

No data available for Paralogs for TCEB2 Gene

Variants for TCEB2 Gene

Sequence variations from dbSNP and Humsavar for TCEB2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3066059 -- 2,778,363(+) TATTG(-/TTG)CTACT upstream-variant-2KB
rs3094772 -- 2,775,815(-) GATAG(C/T)TCAGT intron-variant
rs3094774 -- 2,775,593(-) CCCCA(C/T)GTAGG intron-variant
rs3094776 -- 2,775,275(-) TTTTT(A/T)AAAAA intron-variant
rs3094782 -- 2,774,187(-) AGTGG(C/T)GCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCEB2 Gene

Variant ID Type Subtype PubMed ID
esv2760067 CNV gain+loss 17122850
nsv471073 CNV loss 18288195
nsv827523 CNV gain 20364138

Variation tolerance for TCEB2 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.98; 84.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCEB2 Gene

Disorders for TCEB2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TCEB2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
kidney cancer
  • malignant neoplasm of kidney except pelvis
renal clear cell carcinoma
  • clear cell carcinoma of kidney
familial renal papillary carcinoma
  • hereditary papillary renal carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search TCEB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCEB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEB2
genes like me logo Genes that share disorders with TCEB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCEB2 Gene

Publications for TCEB2 Gene

  1. Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. (PMID: 15574592) Mehle A. … Gabuzda D. (Genes Dev. 2004) 3 4 22 65
  2. Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity. (PMID: 11006129) Aso T. … Kitajima S. (Biochem. Biophys. Res. Commun. 2000) 3 4 22 65
  3. Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog. (PMID: 7638163) Garrett K.P. … Conaway J.W. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 65
  4. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PMID: 22286099) Foxler D.E. … Sharp T.V. (Nat. Cell Biol. 2012) 3 4 65
  5. NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL. (PMID: 18323857) Russell R.C. … Ohh M. (EMBO Rep. 2008) 3 22 65

Products for TCEB2 Gene

Sources for TCEB2 Gene

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