Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCEB2 Gene

protein-coding   GIFtS: 59
GCID: GC16M002824

Transcription Elongation Factor B (SIII), Polypeptide 2...

(Previous names: transcription elongation factor B (SIII), polypeptide 2...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin
B)1 2
     Elongin, 18-KD Subunit2
Elongin 18 KDa Subunit2 3     elongin-B2
RNA Polymerase II Transcription Factor SIII Subunit B2 3     RNA Polymerase II Transcription Factor SIII P18 Subunit2
SIII P182 3     Transcription Elongation Factor B Polypeptide 22
Transcription Elongation Factor B (SIII), Polypeptide 2 (18kD, Elongin B)1     EloB3
ELOB2     Elongin-B3
SIII2     

External Ids:    HGNC: 116191   Entrez Gene: 69232   Ensembl: ENSG000001033637   OMIM: 6007875   UniProtKB: Q153703   

Export aliases for TCEB2 gene to outside databases

Previous GC identifers: GC16M002841 GC16M002822 GC16M002823 GC16M002764 GC16M002765 GC16M002767


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCEB2 Gene:
This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII
complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing
transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the
transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin
A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The
von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription
elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for
this gene. Pseudogenes have been identified on chromosomes 11 and 13. (provided by RefSeq, Aug 2008)

GeneCards Summary for TCEB2 Gene: 
TCEB2 (transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)) is a protein-coding gene. Diseases associated with TCEB2 include renal clear cell carcinoma, and von hippel-lindau disease, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Formation of the Early Elongation Complex. GO annotations related to this gene include protein binding and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot: ELOB_HUMAN, Q15370
Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA
polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally
active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII
regulatory subunits B and C (elongin BC complex)
Function: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of
target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination
complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members
of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes

Gene Wiki entry for TCEB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCEB2 gene promoter:
         AhR   SRF   ER-alpha   AML1a   p53   SRF (504 AA)   GATA-1   AREB6   Egr-2   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCEB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TCEB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p12.3

TCEB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEB2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M002824:  view genomic region     (about GC identifiers)

Start:
2,821,415 bp from pter      End:
2,827,298 bp from pter
Size:
5,884 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ELOB_HUMAN, Q15370 (See protein sequence)
Recommended Name: Transcription elongation factor B polypeptide 2  
Size: 118 amino acids; 13133 Da
Subunit: Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or
CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, TCEB3, VHL or WSB1 (By similarity).
Substrate adapter protein can be a viral protein such as HIV Vif. Interacts with VHL. Found in a complex composed
of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2. Interacts with SPSB1
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAC08452.1; Type=Erroneous gene model prediction;
6/17 PDB 3D structures from and Proteopedia for TCEB2 (see all 17):
1LM8 (3D)        1LQB (3D)        1VCB (3D)        2C9W (3D)        2IZV (3D)        2JZ3 (3D)    
Secondary accessions: B7WPD3
Alternative splicing: 2 isoforms:  Q15370-1   Q15370-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TCEB2: NX_Q15370

Explore proteomics data for TCEB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15370

  • TCEB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCEB2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_009039.1  NP_996896.1  

    ENSEMBL proteins: 
     ENSP00000262306   ENSP00000386652   ENSP00000387189   ENSP00000458213   ENSP00000458443  
    Reactome Protein details: Q15370
    Human Recombinant Protein Products for TCEB2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for TCEB2
    OriGene Protein Over-expression Lysate for TCEB2
    OriGene MassSpec for TCEB2 
    OriGene Custom Protein Services for TCEB2
    GenScript Custom Purified and Recombinant Proteins Services for TCEB2
    Novus Biologicals TCEB2 Proteins
    Novus Biologicals TCEB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TCEB2
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0031462Cul2-RING ubiquitin ligase complex IDA17636018
    GO:0031466Cul5-RING ubiquitin ligase complex IDA17636018

    TCEB2 for ontologies           About GeneDecksing



    TCEB2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TCEB2
    GenScript Custom Superior Antibodies Services for TCEB2
    Novus Biologicals TCEB2 Antibodies
    Abcam antibodies for TCEB2
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for TCEB2
    LSBio Antibodies in human, mouse, rat for TCEB2 

    Assay Products for TCEB2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TCEB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TCEB2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup

    Graphical View of Domain Structure for InterPro Entry Q15370

    ProtoNet protein and cluster: Q15370

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: ELOB_HUMAN, Q15370
    Similarity: Contains 1 ubiquitin-like domain


    TCEB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELOB_HUMAN, Q15370
    Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA
    polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally
    active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII
    regulatory subunits B and C (elongin BC complex)
    Function: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of
    target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination
    complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members
    of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes

         Genatlas biochemistry entry for TCEB2:
    elongin B,18kDa,regulatory subunit of the transcription elongation factor B (SIII),complex SIII,polypeptide 2 (see
    TCEB3). Also complexing with TCEB2,CUL2 and VHL to form the VCB-CUL2 complex (see VHL)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003746translation elongation factor activity ----
    GO:0005515protein binding IPI10205047
    GO:0031625ubiquitin protein ligase binding IDA17636018
         
    TCEB2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TCEB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TCEB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCEB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TCEB2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCEB2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TCEB2:
    hsa-miR-130b* hsa-miR-1827 hsa-miR-216b hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidTCEB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TCEB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCEB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TCEB2
    Sirion Biotech Customized adenovirus for overexpression of TCEB2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TCEB2 (see all 14)
    OriGene ORF clones in mouse, rat for TCEB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TCEB2 (NM_007108)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCEB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEB2
    Sirion Biotech Customized lentivirus for stable overexpression of TCEB2 
                         Customized lentivirus expression plasmids for stable overexpression of TCEB2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TCEB2
    Search LifeMap BioReagents cell lines for TCEB2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TCEB2 About   (see all 17)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript0.78
    HIV elongation arrest and recovery0.74
    HIV Transcription Elongation0.78
    Pausing and recovery of HIV elongation0.74
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.78
    Pausing and recovery of Tat-mediated HIV elongation0.73
    Formation of HIV elongation complex in the absence of HIV Tat0.76
    Tat-mediated HIV elongation arrest and recovery0.73
    3HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    Host Interactions of HIV factors0.60
    4Cellular response to hypoxia
    Cellular response to hypoxia0.72
    Regulation of Hypoxia-inducible Factor (HIF) by Oxygen0.72
    Cellular responses to stress0.72
    Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha0.72
    5Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TCEB2
        Common schema of ubiquitination

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCEB2
        HIF1Alpha Pathway
    JAK-STAT Pathway
    SOCS Pathway

    2 BioSystems Pathways for TCEB2
        Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
    HIF-2-alpha transcription factor network

    5/30        Reactome Pathways for TCEB2 (see all 30)
        Formation of RNA Pol II elongation complex
    Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    Late Phase of HIV Life Cycle


    4         Kegg Pathways  (Kegg details for TCEB2):
        HIF-1 signaling pathway
    Ubiquitin mediated proteolysis
    Pathways in cancer
    Renal cell carcinoma

    UniProtKB/Swiss-Prot: ELOB_HUMAN, Q15370
    Pathway: Protein modification; protein ubiquitination


    TCEB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCEB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/157 Interacting proteins for TCEB2 (Q153701, 2, 3 ENSP000002623064) via UniProtKB, MINT, STRING, and/or I2D (see all 157)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL2Q136172, 3, ENSP000003638804MINT-8295568 MINT-8295466 MINT-7014221 MINT-6543008 MINT-6542668 MINT-8295435 MINT-7014239 MINT-7014201 MINT-8295545 I2D: score=2 STRING: ENSP00000363880
    TCEB1Q153691, 2, 3, ENSP000002848114EBI-301238,EBI-301231 MINT-8295466 MINT-8295568 MINT-7014221 MINT-6543008 MINT-6542668 MINT-8295435 MINT-7014239 MINT-7014201 MINT-68462 MINT-8295545 I2D: score=12 STRING: ENSP00000284811
    RBX1P628772, 3, ENSP000002162254MINT-7014221 MINT-8295435 MINT-7014239 MINT-7014201 I2D: score=2 STRING: ENSP00000216225
    CORO7P577372, 3, ENSP000002511664MINT-8076005 I2D: score=2 STRING: ENSP00000251166
    MED8Q96G251, 3, ENSP000002906634EBI-301238,EBI-394405 I2D: score=2 STRING: ENSP00000290663
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0006461protein complex assembly TAS7660129
    GO:0010467gene expression TAS--
    GO:0016032viral process TAS--

    TCEB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TCEB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCEB2 (ELOB)

    2 Novoseek inferred chemical compound relationships for TCEB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 25.9 2 9652757 (1), 9751722 (1)
    glucose 0 1 9891082 (1)

    Search CenterWatch for drugs/clinical trials and news about TCEB2 / ELOB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCEB2 gene (2 alternative transcripts): 
    NM_007108.3  NM_207013.2  

    Unigene Cluster for TCEB2:

    Transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
    Hs.172772  [show with all ESTs]
    Unigene Representative Sequence: BU603847
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262306 ENST00000409906(uc002crm.3 uc002crn.3) ENST00000409477
    ENST00000494946 ENST00000572954
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCEB2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TCEB2:
    hsa-miR-130b* hsa-miR-1827 hsa-miR-216b hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidTCEB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TCEB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCEB2
    Clone
    Products:
         
    OriGene clones in human, mouse for TCEB2 (see all 14)
    OriGene ORF clones in mouse, rat for TCEB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TCEB2 (NM_007108)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCEB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEB2
    Sirion Biotech Customized lentivirus for stable overexpression of TCEB2 
                         Customized lentivirus expression plasmids for stable overexpression of TCEB2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TCEB2
    OriGene qSTAR qPCR primer pairs in human, mouse for TCEB2
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TCEB2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCEB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEB2

    Additional mRNA sequence: 

    BC013306.2 BC065000.1 L42856.1 

    18 DOTS entries:

    DT.95311881  DT.99944138  DT.120719014  DT.91801633  DT.120719050  DT.100044448  DT.100813992  DT.99955467 
    DT.91747758  DT.120718902  DT.120719001  DT.95311830  DT.120739630  DT.95311832  DT.97759922  DT.102839219 
    DT.451624  DT.91707108 

    24/378 AceView cDNA sequences (see all 378):

    AI188746 T35945 BM669977 BM924966 BG943820 F09446 CB243885 L42856 
    BQ216099 NM_207013 BM698429 NM_007108 AJ572509 BU752143 BM765460 BM921799 
    BM700019 AI802308 R29137 AI338594 BU960257 AA313970 T24841 BI836560 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TCEB2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5
    SP1:              -                       -     -         
    SP2:              -                                       
    SP3:              -           -                           
    SP4:                                                      


    ECgene alternative splicing isoforms for TCEB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCEB2 expression in normal human tissues (normalized intensities)      TCEB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCGGCGCC
    TCEB2 Expression
    About this image


    TCEB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             visceral organ/urogenital sinus/primitive bladder   
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
     
     Kidney (Urinary System)
             Metanephros
     
     Testis (Reproductive System)
     
     Ovary (Reproductive System)

    See TCEB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCEB2

    SOURCE GeneReport for Unigene cluster: Hs.172772
        SABiosciences Expression via Pathway-Focused PCR Array including TCEB2: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TCEB2
    OriGene qSTAR qPCR primer pairs in human, mouse for TCEB2
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TCEB2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCEB2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TCEB2 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tceb21 , 5 transcription elongation factor B (SIII), polypeptide more1, 5 90.88(n)1
    97.44(a)1
      17 (12.08 cM)5
    676731  NM_026305.21  NP_080581.11 
     238247405 
    lizard
    (Anolis carolinensis)
    Reptilia TCEB26
    Uncharacterized protein
    87(a)
    1 ↔ 1
    GL343287.1(1437653-1440819)
    African clawed frog
    (Xenopus laevis)
    Amphibia tceb2-prov2 transcription elongation factor B (SIII) polypeptide more 77.13(n)    BC056504.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tceb22 Danio rerio cDNA clone IMAGE5915037, partial cds 75.48(n)    BC054698.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Elongin-B1 Elongin B 63.79(n)
    56.03(a)
      42435  NM_079692.3  NP_524416.1 
    worm
    (Caenorhabditis elegans)
    Secernentea elb-16
    Protein ELB-1
    36(a)
    1 ↔ 1
    III(11718836-11719452)


    ENSEMBL Gene Tree for TCEB2 (if available)
    TreeFam Gene Tree for TCEB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCEB2 gene

    TCEB2 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for TCEB2
    PGOHUM00000238402 PGOHUM00000242537 PGOHUM00000248339 PGOHUM00000240638


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/188 SNPs in TCEB2 are shown (see all 188)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1393503541,2
    C--2821949(+) GACTCA/CCAAAT 2 -- ut31 int10--------
    rs71928491,2
    C--2821957(+) AATCTC/TTTTTA 2 -- ut31 int10--------
    rs2018498671,2
    --2821984(+) TCTTGA/GGGGTC 2 -- ut31 int10--------
    rs743402021,2
    C--2821988(+) GGGGGG/TCCTCA 2 -- ut31 int10--------
    rs32141911,2
    C--2821989(-) GTGAGG/-ACCCC 2 -- ut31 int12Minor allele frequency- -:0.00NA 4
    rs782923781,2
    C--2821989(+) GGGGTC/TCTCAC 2 -- ut31 int10--------
    rs2013713901,2
    C--2822024(+) CTTCCC/TGAGTC 4 S syn11Minor allele frequency- T:0.00EU 1313
    rs1923499701,2
    --2822030(+) GAGTCC/TTGGGG 4 Q syn10--------
    rs734964001,2
    C--2822116(+) GGAAGC/GAGCAG 2 -- int14Minor allele frequency- G:0.13WA CSA 124
    rs734964011,2
    C--2822129(+) CTGCAG/CGGGGG 2 -- int14Minor allele frequency- C:0.13WA CSA 124

    HapMap Linkage Disequilibrium report for TCEB2 (2821415 - 2827298 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TCEB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv905167CNV Loss21882294
    nsv905165CNV Loss21882294
    nsv905152CNV Loss21882294
    nsv905170CNV Loss21882294
    nsv471073CNV Loss18288195
    dgv2573n71CNV Loss21882294
    nsv905169CNV Loss21882294
    nsv905162CNV Gain21882294
    nsv827523CNV Gain20364138
    dgv793e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TCEB2
    DNA2.0 Custom Variant and Variant Library Synthesis for TCEB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600787    OMIM disorders: --

    16 diseases for TCEB2:    About MalaCards
    renal clear cell carcinoma    von hippel-lindau disease    kidney cancer    hemangioma
    hypoxia    pheochromocytoma    kidney disease    renal cell carcinoma
    cervical cancer    parkinson's disease    cervicitis    hepatocellular carcinoma
    thyroiditis    leukemia    neuronitis    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for TCEB2:
    Hemangioma     Renal cell carcinoma

    TCEB2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for TCEB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal clear cell carcinoma 77 1 9652757 (1)
    von hippel-lindau disease 71.7 2 9652757 (1), 11278610 (1)
    carcinoma renal cell 65.7 3 9751722 (1), 8700833 (1), 11526493 (1)
    tumors 36.9 18 7660130 (3), 9341197 (2), 9447969 (1), 10850421 (1) (see all 14)


    Export disorders for TCEB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCEB2 gene, integrated from 9 sources (see all 196):
    (articles sorted by number of sources associating them with TCEB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog. (PubMed id 7638163)1, 2, 3 Garrett K.P.... Conaway J.W. (1995)
    2. Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity. (PubMed id 11006129)1, 2, 9 Aso T.... Kitajima S. (2000)
    3. Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. (PubMed id 15574592)1, 2, 9 Mehle A.... Gabuzda D. (2004)
    4. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PubMed id 22286099)1, 2 Foxler D.E.... Sharp T.V. (2012)
    5. Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. (PubMed id 15590694)1, 2 Kario E....Yarden Y. (2005)
    6. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling. (PubMed id 12004076)1, 2 Min J.-H....Pavletich N.P. (2002)
    9. Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. (PubMed id 12050673)1, 2 Hon W.-C.... Jones E.Y. (2002)
    10. Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. (PubMed id 10205047)1, 2 Stebbins C.E.... Pavletich N.P. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6923 HGNC: 11619 AceView: TCEB2 Ensembl:ENSG00000103363 euGenes: HUgn6923
    ECgene: TCEB2 Kegg: 6923 H-InvDB: TCEB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCEB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TCEB2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCEB2 gene:
    Search GeneIP for patents involving TCEB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TCEB2  
     OriGene qPCR primer pairs and template standards for TCEB2   OriGene Protein Over-expression Lysate for TCEB2  
     OriGene MassSpec something-or-other for TCEB2   OriGene clones in human, mouse for TCEB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TCEB2   OriGene Purified Protein for TCEB2  
     OriGene ORF clones in mouse, rat for TCEB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TCEB2   OriGene Custom Protein Services for TCEB2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCEB2
     QIAGEN SeqTarget long-range PCR primers for resequencing TCEB2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEB2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCEB2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEB2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCEB2
     GenScript Custom Purified and Recombinant Proteins Services for TCEB2 GenScript cDNA clones with any tag delivered in your preferred vector for TCEB2
     GenScript Custom Assay Services for TCEB2 GenScript Custom Superior Antibodies Services for TCEB2
     GenScript Custom overexpressing Cell Line Services for TCEB2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TCEB2 promoter
     Search Chromatin IP Primers for TCEB2
     RT2 qPCR Primer Assay in human, mouse / rat TCEB2
     GNC Network for TCEB2
     SABiosciences PCR Arrays including human, mouse / rat TCEB2
     Search Tocris compounds for TCEB2 (ELOB)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TCEB2 antibodies
     TCEB2 proteins
     TCEB2 lysates
     Antibodies for TCEB2
     See all of Abcam's Antibodies, Kits and Proteins for TCEB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TCEB2




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for TCEB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEB2
     SwitchGear 3'UTR luciferase reporter plasmids for TCEB2
     SwitchGear Promoter luciferase reporter plasmids for TCEB2
     Search ThermoFisher Antibodies for TCEB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEB2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TCEB2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TCEB2
    Customized:
     lentivirus for stable overexpression of TCEB2
     lentivirus expression plasmids for stable overexpression of TCEB2
     adenovirus for overexpression of TCEB2
     LSBio Antibodies in human, mouse, rat for TCEB2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TCEB2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4