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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TCEB2 Gene

protein-coding GIFtS: 60
GCID: GC16M002824

transcription elongation factor B (SIII), polypeptide 2...

(Previous names: transcription elongation factor B (SIII), polypeptide 2...)

Explore 17 diseases affiliated with
TCEB2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B)¹ ²		Elongin, 18-KD Subunit²
SIII¹ ²		Elongin-B³
Elongin 18 KDa Subunit² ³		RNA Polymerase II Transcription Factor SIII P18 Subunit²
RNA Polymerase II Transcription Factor SIII Subunit B² ³		Transcription Elongation Factor B Polypeptide 2²
SIII P18² ³		EloB³
Transcription Elongation Factor B (SIII), Polypeptide 2 (18kD, Elongin B)¹		Elongin-B³
ELOB²

External Ids:	HGNC: 11619¹	Entrez Gene: 6923²	Ensembl: ENSG00000103363⁷	OMIM: 600787⁵	UniProtKB: Q15370³

Export aliases for TCEB2 gene to outside databases

Previous GC identifers: GC16M002841 GC16M002822 GC16M002823 GC16M002764 GC16M002765 GC16M002767

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCEB2:

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII

complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient

pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally

active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically

expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor

suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced

transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on

chromosomes 11 and 13. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: ELOB_HUMAN, Q15370

Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase

II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its

transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C

(elongin BC complex)

Function: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target

proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL).

By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family,

to Cullin/RBX1 modules that activate E2 ubiquitination enzymes

Gene Wiki entry for TCEB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TCEB2 gene promoter:
AhR SRF ER-alpha AML1a p53 SRF (504 AA) GATA-1 AREB6 Egr-2 c-Myb
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TCEB2 promoter sequence

Search SABiosciences Chromatin IP Primers for TCEB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p12.3

TCEB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEB2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M002824: view genomic region (about GC identifiers)

Start:	2,821,415 bp from pter	End:	2,827,298 bp from pter
Size:	5,884 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ELOB_HUMAN, Q15370 (See protein sequence)

Recommended Name: Transcription elongation factor B polypeptide 2

Size: 118 amino acids; 13133 Da

Subunit: Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2,

RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, TCEB3, VHL or WSB1 (By similarity). Substrate

adapter protein can be a viral protein such as HIV Vif. Interacts with VHL. Found in a complex composed of LIMD1, VHL,

EGLN1/PHD2, TCEB2 AND CUL2

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=AAC08452.1; Type=Erroneous gene model prediction;

6/17 PDB 3D structures from and Proteopedia for TCEB2 (see all 17):

1LM8 (3D)

1LQB (3D)

1VCB (3D)

2C9W (3D)

2IZV (3D)

2JZ3 (3D)

Secondary accessions: B7WPD3

Alternative splicing: 2 isoforms: Q15370-1 Q15370-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TCEB2: NX_Q15370

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15370

TCEB2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_009039.1 NP_996896.1

ENSEMBL proteins:

ENSP00000262306 ENSP00000386652 ENSP00000387189 ENSP00000458213 ENSP00000458443

Reactome Protein details: Q15370
Human Recombinant Protein Products for TCEB2:

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	Uscn Proteins for TCEB2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	--
GO:0031462	Cul2-RING ubiquitin ligase complex	IDA	17636018
GO:0031466	Cul5-RING ubiquitin ligase complex	IDA	17636018

TCEB2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TCEB2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TCEB2 for domains About GeneDecksing

2 InterPro domains/families:

IPR000626 Ubiquitin

IPR019955 Ubiquitin_supergroup

Graphical View of Domain Structure for InterPro Entry Q15370

ProtoNet protein and cluster: Q15370

1 Blocks protein family: IPB000626 Ubiquitin domain

UniProtKB/Swiss-Prot: ELOB_HUMAN, Q15370

Similarity: Contains 1 ubiquitin-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ELOB_HUMAN, Q15370

Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase

II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its

transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C

(elongin BC complex)

Function: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target

proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL).

By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family,

to Cullin/RBX1 modules that activate E2 ubiquitination enzymes

Genatlas biochemistry entry for TCEB2:

elongin B,18kDa,regulatory subunit of the transcription elongation factor B (SIII),complex SIII,polypeptide 2 (see

TCEB3). Also complexing with TCEB2,CUL2 and VHL to form the VCB-CUL2 complex (see VHL)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003746	translation elongation factor activity	--	--
GO:0005515	protein binding	IPI	--
GO:0031625	ubiquitin protein ligase binding	IDA	17636018

TCEB2 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TCEB2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Formation of RNA Pol II elongation complex

8/13 pathways (see all 13)
RNA Polymerase II Transcription Elongation	1.00	Pausing and recovery of HIV-1 elongation	0.74
Formation of HIV-1 elongation complex in the absence of HIV-1 Tat	1.00	Elongation arrest and recovery	0.74
Formation of RNA Pol II elongation complex	1.00	RNA Polymerase II Pre-transcription Events	0.72
Formation of HIV-1 elongation complex containing HIV-1 Tat	0.98	Tat-mediated HIV-1 elongation arrest and recovery	0.71

Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha

Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha	1.00	Destruction of Ubiquitinated HIF-alpha by the Proteasome	0.67
Cellular response to hypoxia	0.72	Nuclear Export of Ubiquitinated HIF-alpha:VHL:EloB/C:CUL2:RBX1 Complex	0.67
Cellular responses to stress	0.72	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.27
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen	0.72

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83			Ubiquitin mediated proteolysis	0.36

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Late Phase of HIV Life Cycle

Late Phase of HIV Life Cycle

1.00

HIV Life Cycle

0.90

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TCEB2

Common schema of ubiquitination

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCEB2

	HIF1Alpha Pathway
	JAK-STAT Pathway
	SOCS Pathway

2 BioSystems Pathways for TCEB2

	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
	HIF-2-alpha transcription factor network

5/34 Reactome Pathways for TCEB2 (see all 34)

	Tat-mediated HIV-1 elongation arrest and recovery
	Tat-mediated elongation of the HIV-1 transcript
	Cellular responses to stress
	Destruction of Ubiquitinated HIF-alpha by the Proteasome
	Antigen processing: Ubiquitination & Proteasome degradation

3 Kegg Pathways (Kegg details for TCEB2):

	Ubiquitin mediated proteolysis
	Pathways in cancer
	Renal cell carcinoma

UniProtKB/Swiss-Prot: ELOB_HUMAN, Q15370

Pathway: Protein modification; protein ubiquitination

TCEB2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TCEB2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/158 Interacting proteins for TCEB2 (Q15370^{1, 2, 3} ENSP00000262306⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 158)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CUL2	Q13617²^,³, ENSP00000363880⁴	MINT-8295568 MINT-8295466 MINT-7014221 MINT-6543008 MINT-6542668 MINT-8295435 MINT-7014239 MINT-7014201 MINT-8295545 I2D: score=2 STRING: ENSP00000363880
TCEB1	Q15369¹^,²^,³, ENSP00000284811⁴	EBI-301238,EBI-301231 MINT-8295466 MINT-8295568 MINT-7014221 MINT-6543008 MINT-6542668 MINT-8295435 MINT-7014239 MINT-7014201 MINT-68462 MINT-8295545 I2D: score=12 STRING: ENSP00000284811
RBX1	P62877²^,³, ENSP00000216225⁴	MINT-7014221 MINT-8295435 MINT-7014239 MINT-7014201 I2D: score=2 STRING: ENSP00000216225
MED8	Q96G25¹^,³, ENSP00000290663⁴	EBI-301238,EBI-394405 I2D: score=2 STRING: ENSP00000290663
CORO7	P57737²^,³	MINT-8076005 I2D: score=2

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	--
GO:0006368	transcription elongation from RNA polymerase II promoter	TAS	--
GO:0006461	protein complex assembly	TAS	7660129
GO:0010467	gene expression	TAS	--

TCEB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TCEB2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TCEB2
2 Novoseek chemical compound relationships for TCEB2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vegf	25.9	2	9652757 (1), 9751722 (1)
glucose	0	1	9891082 (1)

Search CenterWatch for drugs/clinical trials and news about TCEB2 / ELOB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TCEB2 gene (2 alternative transcripts):

NM_007108.3 NM_207013.2

Unigene Cluster for TCEB2:

Transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)

Hs.172772 [show with all ESTs]

Unigene Representative Sequence: BU603847

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000262306 ENST00000409906(uc002crm.3 uc002crn.3) ENST00000409477

ENST00000494946 ENST00000572954

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Additional cDNA sequence:

BC013306.2 BC065000.1 L42856.1

18 DOTS entries:

DT.95311881 DT.99944138 DT.120719014 DT.91801633 DT.120719050 DT.100044448 DT.100813992 DT.99955467

DT.91747758 DT.120718902 DT.120719001 DT.95311830 DT.120739630 DT.95311832 DT.97759922 DT.102839219

DT.451624 DT.91707108

24/378 AceView cDNA sequences (see all 378):

AJ572509 BM924966 NM_007108 BM669977 BM700019 AI188746 T35945 BG943820

F09446 CB243885 L42856 NM_207013 BQ216099 BM765460 BU752143 AI338594

R29137 AI802308 BM921799 BM698429 F31843 AA994558 BQ233648 AA584218

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TCEB2 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	^	5
SP1:					-								-		-
SP2:					-
SP3:					-				-
SP4:

ECgene alternative splicing isoforms for TCEB2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TCEB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCCGGCGCC

About this image

TCEB2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TCEB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCEB2

SOURCE GeneReport for Unigene cluster: Hs.172772

SABiosciences Expression via Pathway-Focused PCR Array including TCEB2:

Ubiquitin Ligases in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEB2

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TCEB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TCEB2 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tceb2^{1 , 5}	transcription elongation factor B (SIII), polypeptide more^{1, 5}	90.88(n)¹ 97.44(a)¹		17 (12.08 cM)⁵ 67673¹ NM_026305.2¹ NP_080581.1¹ 23824740⁵
lizard (Anolis carolinensis)	Reptilia	TCEB2⁶	--	87(a)	1 ↔ 1	GL343287.1(1437653-1440819)
African clawed frog (Xenopus laevis)	Amphibia	tceb2-prov²	transcription elongation factor B (SIII) polypeptide more	77.13(n)		BC056504.1
zebrafish (Danio rerio)	Actinopterygii	tceb2²	Danio rerio cDNA clone IMAGE5915037, partial cds	75.48(n)		BC054698.1
fruit fly (Drosophila melanogaster)	Insecta	Elongin-B¹	Elongin B	63.79(n) 56.03(a)		42435 NM_079692.3 NP_524416.1
worm (Caenorhabditis elegans)	Secernentea	elb-1⁶	ELongin B family member (elb-1)	35(a)	1 ↔ 1	III(11718736-11719352)

ENSEMBL Gene Tree for TCEB2 (if available)
TreeFam Gene Tree for TCEB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TCEB2 gene

TCEB2 for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for TCEB2
PGOHUM00000238402 PGOHUM00000242537 PGOHUM00000248339 PGOHUM00000240638

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138948846^1,2		--	2821008(+)	`TTTCCC/TTCCCC`	3	--	ut3¹ int¹		0	--	--	--	--
rs78617860^1,2	C,F	--	2821023(+)	`TTTTTT/CCTTTG`	3	--	ut3¹ int¹		1		WA	118
rs111748580^1,2	F	--	2821100(+)	`AGGGAG/ATGCAG`	3	--	int¹ ut3¹		1		CSA	4
rs75586278^1,2	C,F	--	2821115(+)	`GAGTTG/TGGGGA`	3	--	ut3¹ int¹		1		WA	118
rs149417935^1,2		--	2821190(+)	`TATCCA/CGAAGT`	3	--	ut3¹ int¹		0	--	--	--	--
rs183204995^1,2		--	2821235(+)	`AGGTTA/GTATAA`	3	--	int¹ ut3¹		0	--	--	--	--
rs8843^1,2		--	2821251(+)	`TCTTGG/AAAGGA`	3	--	ut3¹ int¹		3		MN NA	188
rs188485694^1,2		--	2821373(+)	`AGCAAC/GAGCAA`	3	--	int¹ ut3¹		0	--	--	--	--
rs116928678^1,2		--	2821382(+)	`AACTTT/CTTCTG`	3	--	ut3¹ int¹		1		NA	120
rs76875659^1,2		--	2821416(+)	`GAACTC/GGGTCT`	3	--	ut3¹ ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TCEB2 (2821415 - 2827298 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TCEB2
1 CNV: 3988

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TCEB2 for disorders           About GeneDecksing

OMIM gene information: 600787    OMIM disorders: --

17 diseases for TCEB2:    About MalaCards

von hippel-lindau disease renal clear cell carcinoma renal cell carcinoma hemangioma

kidney disease parkinson's disease kidney cancer pheochromocytoma

carcinoma hepatocellular carcinoma cervical cancer cervicitis

hypoxia immunodeficiency thyroiditis leukemia

neuronitis

2 diseases from the University of Copenhagen DISEASES database for TCEB2:

Hemangioma Renal cell carcinoma

4 Novoseek disease relationships for TCEB2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
renal clear cell carcinoma	77	1	9652757 (1)
von hippel-lindau disease	71.7	2	9652757 (1), 11278610 (1)
carcinoma renal cell	65.7	3	9751722 (1), 8700833 (1), 11526493 (1)
tumors	36.9	18	7660130 (3), 9341197 (2), 9447969 (1), 10850421 (1) (see all 14)

Export disorders for TCEB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TCEB2 gene, integrated from 9 sources (see all 184):
(articles sorted by number of sources associating them with TCEB2)

Utopia: connect your pdf to the dynamic
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Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog. (PubMed id 7638163)^{1, 2, 3} Garrett K.P.... Conaway J.W. (1995)
Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity. (PubMed id 11006129)^{1, 2, 9} Aso T.... Kitajima S. (2000)
Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. (PubMed id 15574592)^{1, 2, 9} Mehle A.... Gabuzda D. (2004)
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PubMed id 22286099)^{1, 2} Foxler D.E.... Sharp T.V. (2012)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)^{1, 2} Martin J.... Pennacchio L.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling. (PubMed id 12004076)^{1, 2} Min J.-H....Pavletich N.P. (2002)
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. (PubMed id 12050673)^{1, 2} Hon W.-C.... Jones E.Y. (2002)
Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. (PubMed id 10205047)^{1, 2} Stebbins C.E.... Pavletich N.P. (1999)
Ternary complex formation of pVHL, elongin B and elongin C visualized in living cells by a fluorescence resonance energy transfer-fluorescence lifetime imaging microscopy technique. (PubMed id 17922844)^{1, 9} Kinoshita K....Sogawa K. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6923	HGNC: 11619	AceView: TCEB2	Ensembl:ENSG00000103363	euGenes: HUgn6923
ECgene: TCEB2	Kegg: 6923	H-InvDB: TCEB2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TCEB2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TCEB2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TCEB2 gene
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Patent Information for TCEB2 gene:
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GeneCards and IP:
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transcription elongation factor B (SIII), polypeptide 2...

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