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Aliases for TCEB2 Gene

Aliases for TCEB2 Gene

  • Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) 2 3
  • RNA Polymerase II Transcription Factor SIII Subunit B 3 4
  • Elongin 18 KDa Subunit 3 4
  • Elongin-B 3 4
  • SIII P18 3 4
  • ELOB 3 4
  • Transcription Elongation Factor B (SIII), Polypeptide 2 (18kD, Elongin B) 2
  • RNA Polymerase II Transcription Factor SIII P18 Subunit 3
  • Transcription Elongation Factor B Polypeptide 2 3
  • Elongin, 18-KD Subunit 3
  • SIII 3

External Ids for TCEB2 Gene

Summaries for TCEB2 Gene

Entrez Gene Summary for TCEB2 Gene

  • This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

GeneCards Summary for TCEB2 Gene

TCEB2 (Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B)) is a Protein Coding gene. Diseases associated with TCEB2 include hiv-1. Among its related pathways are TGF-Beta Pathway and Disease. GO annotations related to this gene include ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for TCEB2 Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)

  • The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes

Gene Wiki entry for TCEB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEB2 Gene

Genomics for TCEB2 Gene

Genomic Location for TCEB2 Gene

Start:
2,771,414 bp from pter
End:
2,777,297 bp from pter
Size:
5,884 bases
Orientation:
Minus strand

Genomic View for TCEB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEB2 Gene

Regulatory Elements for TCEB2 Gene

Proteins for TCEB2 Gene

  • Protein details for TCEB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15370-ELOB_HUMAN
    Recommended name:
    Transcription elongation factor B polypeptide 2
    Protein Accession:
    Q15370
    Secondary Accessions:
    • B7WPD3

    Protein attributes for TCEB2 Gene

    Size:
    118 amino acids
    Molecular mass:
    13133 Da
    Quaternary structure:
    • Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, TCEB3, VHL or WSB1. Substrate adapter protein can be a viral protein such as HIV Vif. Interacts with VHL. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2. Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component.
    SequenceCaution:
    • Sequence=AAC08452.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TCEB2 Gene

    Alternative splice isoforms for TCEB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEB2 Gene

Proteomics data for TCEB2 Gene at MOPED

Post-translational modifications for TCEB2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys36 and Lys46

Other Protein References for TCEB2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TCEB2 Gene

Domains for TCEB2 Gene

Protein Domains for TCEB2 Gene

UniProtKB/Swiss-Prot:

ELOB_HUMAN
Domain:
  • Contains 1 ubiquitin-like domain.:
    • Q15370
genes like me logo Genes that share domains with TCEB2: view

No data available for Gene Families for TCEB2 Gene

Function for TCEB2 Gene

Molecular function for TCEB2 Gene

GENATLAS Biochemistry: elongin B,18kDa,regulatory subunit of the transcription elongation factor B (SIII),complex SIII,polypeptide 2 (see TCEB3). Also complexing with TCEB2,CUL2 and VHL to form the VCB-CUL2 complex (see VHL)
UniProtKB/Swiss-Prot Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)
UniProtKB/Swiss-Prot Function: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes

Gene Ontology (GO) - Molecular Function for TCEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity --
GO:0005515 protein binding IPI 10205047
GO:0031625 ubiquitin protein ligase binding IDA 17636018
genes like me logo Genes that share ontologies with TCEB2: view

miRNA for TCEB2 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TCEB2 Gene

Localization for TCEB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEB2 Gene COMPARTMENTS Subcellular localization image for TCEB2 gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for TCEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0031462 Cul2-RING ubiquitin ligase complex IDA 17636018
GO:0031466 Cul5-RING ubiquitin ligase complex IDA 17636018
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TCEB2: view

Pathways for TCEB2 Gene

genes like me logo Genes that share pathways with TCEB2: view

UniProtKB/Swiss-Prot Q15370-ELOB_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TCEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0006414 translational elongation --
GO:0006461 protein complex assembly TAS 7660129
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with TCEB2: view

Compounds for TCEB2 Gene

(2) Novoseek inferred chemical compound relationships for TCEB2 Gene

Compound -log(P) Hits PubMed IDs
vegf 25.9 2
glucose 0 1
genes like me logo Genes that share compounds with TCEB2: view

Transcripts for TCEB2 Gene

Unigene Clusters for TCEB2 Gene

Transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCEB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5
SP1: - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for TCEB2 Gene

GeneLoc Exon Structure for
TCEB2
ECgene alternative splicing isoforms for
TCEB2

Expression for TCEB2 Gene

mRNA expression in normal human tissues for TCEB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCEB2 Gene

SOURCE GeneReport for Unigene cluster for TCEB2 Gene Hs.172772

genes like me logo Genes that share expressions with TCEB2: view

Orthologs for TCEB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCEB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 98 (a)
OneToMany
-- 37
  • 97 (a)
OneToMany
TCEB2 36
  • 99.38 (n)
  • 98.14 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 96 (a)
OneToMany
-- 37
  • 84 (a)
OneToMany
-- 37
  • 91 (a)
OneToMany
TCEB2 36
  • 88.42 (n)
  • 96.61 (a)
TCEB2 37
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC479873 36
  • 89.77 (n)
  • 96.49 (a)
TCEB2 37
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tceb2 16
Tceb2 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 92 (a)
OneToMany
-- 37
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TCEB2 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909963 36
  • 88.03 (n)
  • 94.02 (a)
lizard
(Anolis carolinensis)
Reptilia TCEB2 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tceb2-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76322 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13460 36
zebrafish
(Danio rerio)
Actinopterygii tceb2 36
tceb2 37
  • 85 (a)
OneToMany
TCEB2 (2 of 2) 37
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Elongin-B 37
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea elb-1 37
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4437 37
  • 55 (a)
OneToOne
Species with no ortholog for TCEB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCEB2 Gene

ENSEMBL:
Gene Tree for TCEB2 (if available)
TreeFam:
Gene Tree for TCEB2 (if available)

Paralogs for TCEB2 Gene

Pseudogenes.org Pseudogenes for TCEB2 Gene

genes like me logo Genes that share paralogs with TCEB2: view

No data available for Paralogs for TCEB2 Gene

Variants for TCEB2 Gene

Sequence variations from dbSNP and Humsavar for TCEB2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs916947 -- 2,774,983(-) ATGCT(A/G)TGTAT intron-variant
rs2009509 -- 2,774,929(-) TGCCA(C/G)TTTTC intron-variant
rs2285877 -- 2,772,173(-) TCACA(C/T)GTGAA intron-variant
rs2335454 -- 2,778,156(+) TGGAA(C/G)GTGGA upstream-variant-2KB
rs2335455 -- 2,778,172(+) GATTT(C/T)TGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TCEB2 Gene

Variant ID Type Subtype PubMed ID
nsv905152 CNV Loss 21882294
dgv793e1 CNV Complex 17122850
nsv905162 CNV Gain 21882294
nsv471073 CNV Loss 18288195
nsv905165 CNV Loss 21882294
dgv2573n71 CNV Loss 21882294
nsv905167 CNV Loss 21882294
nsv905169 CNV Loss 21882294
nsv905170 CNV Loss 21882294
nsv827523 CNV Gain 20364138

Relevant External Links for TCEB2 Gene

HapMap Linkage Disequilibrium report
TCEB2

Disorders for TCEB2 Gene

(1) MalaCards Diseases for TCEB2 Gene

Search for TCEB2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for TCEB2 Gene

(4) Novoseek inferred disease relationships for TCEB2 Gene

Disease -log(P) Hits PubMed IDs
renal clear cell carcinoma 77 1
von hippel-lindau disease 71.7 2
carcinoma renal cell 65.7 3
tumors 36.9 17
genes like me logo Genes that share disorders with TCEB2: view

No data available for UniProtKB/Swiss-Prot for TCEB2 Gene

Publications for TCEB2 Gene

  1. Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity. (PMID: 11006129) Aso T. … Kitajima S. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  2. Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. (PMID: 15574592) Mehle A. … Gabuzda D. (Genes Dev. 2004) 3 4 23
  3. Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog. (PMID: 7638163) Garrett K.P. … Conaway J.W. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4
  4. NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL. (PMID: 18323857) Russell R.C. … Ohh M. (EMBO Rep. 2008) 3 23
  5. Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. (PMID: 10205047) Stebbins C.E. … Pavletich N.P. (Science 1999) 3 4

Products for TCEB2 Gene

Sources for TCEB2 Gene

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