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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCEB1 Gene

protein-coding   GIFtS: 61
GCID: GC08M074858

Transcription Elongation Factor B (SIII), Polypeptide 1...

(Previous names: transcription elongation factor B (SIII), polypeptide 1...)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcription Elongation Factor B (SIII), Polypeptide 1 (15kDa, Elongin
C)1 2
     SIII2
Elongin 15 KDa Subunit2 3     eloC2
RNA Polymerase II Transcription Factor SIII Subunit C2 3     Transcription Elongation Factor B Polypeptide 12
SIII P152 3     EloC3
Transcription Elongation Factor B (SIII), Polypeptide 1 (15kD, Elongin C)1     Elongin-C3

External Ids:    HGNC: 116171   Entrez Gene: 69212   Ensembl: ENSG000001545827   OMIM: 6007885   UniProtKB: Q153693   

Export aliases for TCEB1 gene to outside databases

Previous GC identifers: GC08M073910 GC08M074797 GC08M074580 GC08M074907 GC08M075019 GC08M070349


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCEB1 Gene:
This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII
complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing
transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the
transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin
A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The
von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription
elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been
identified. (provided by RefSeq, Mar 2011)

GeneCards Summary for TCEB1 Gene: 
TCEB1 (transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)) is a protein-coding gene. Diseases associated with TCEB1 include von hippel-lindau disease, and renal clear cell carcinoma, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Formation of the Early Elongation Complex. GO annotations related to this gene include protein binding and protein complex binding.

UniProtKB/Swiss-Prot: ELOC_HUMAN, Q15369
Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA
polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally
active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII
regulatory subunits B and C (elongin BC complex)
Function: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of
target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination
complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members
of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes

Gene Wiki entry for TCEB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCEB1 gene promoter:
         TBP   STAT1   AML1a   AP-1   ATF-2   IRF-1   MZF-1   c-Jun   Msx-1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCEB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TCEB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11   Ensembl cytogenetic band:  8q21.11   HGNC cytogenetic band: 8q13.3

TCEB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEB1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M074858:  view genomic region     (about GC identifiers)

Start:
74,851,404 bp from pter      End:
74,884,522 bp from pter
Size:
33,119 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ELOC_HUMAN, Q15369 (See protein sequence)
Recommended Name: Transcription elongation factor B polypeptide 1  
Size: 112 amino acids; 12473 Da
Subunit: Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or
CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, TCEB3, VHL or WSB1 (By similarity).
The elongin BC complex is part of a complex with hydroxylated HIF1A. Substrate adapter protein can be a viral
protein such as HIV Vif. Interacts with VHL. Interacts with TMF1. Interacts with human respiratory syncytial
virus (HRSV) protein NS1. Interacts with SPSB1
Subcellular location: Nucleus (Probable)
6/16 PDB 3D structures from and Proteopedia for TCEB1 (see all 16):
1LM8 (3D)        1LQB (3D)        1VCB (3D)        2C9W (3D)        2IZV (3D)        3DCG (3D)    
Secondary accessions: E5RGD9 Q567Q6
Alternative splicing: 2 isoforms:  Q15369-1   Q15369-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TCEB1: NX_Q15369

Explore proteomics data for TCEB1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15369

  • TCEB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCEB1 Protein Expression
    REFSEQ proteins (9 alternative transcripts): 
    NP_001191786.1  NP_001191787.1  NP_001191788.1  NP_001191789.1  NP_001191790.1  NP_001191791.1  NP_001191792.1  NP_001191793.1  
    NP_005639.1  

    ENSEMBL proteins: 
     ENSP00000473408   ENSP00000428334   ENSP00000430224   ENSP00000428171   ENSP00000429596  
     ENSP00000284811   ENSP00000429906   ENSP00000428074   ENSP00000429789  
    Reactome Protein details: Q15369
    Human Recombinant Protein Products for TCEB1: 
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    Novus Biologicals TCEB1 Proteins
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TCEB1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0030891VCB complex IEA--

    TCEB1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001232 Skp1_comp
     IPR011333 BTB/POZ_fold
     IPR016073 Skp1_comp_POZ

    Graphical View of Domain Structure for InterPro Entry Q15369

    ProtoNet protein and cluster: Q15369

    UniProtKB/Swiss-Prot: ELOC_HUMAN, Q15369
    Similarity: Belongs to the SKP1 family


    TCEB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELOC_HUMAN, Q15369
    Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA
    polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally
    active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII
    regulatory subunits B and C (elongin BC complex)
    Function: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of
    target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination
    complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members
    of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes

         Genatlas biochemistry entry for TCEB1:
    elongin C,15kDa,regulatory subunit of the transcription elongation factor B (SIII),complex SIII,polypeptide 1 (see
    TCEB3). Also complexing with TCEB2,CUL2 and VHL to form the VCB-CUL2 complex (see VHL)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10205047
    GO:0032403protein complex binding IEA--
         
    TCEB1 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidTCEB1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TCEB1 About   (see all 17)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript0.78
    HIV elongation arrest and recovery0.74
    HIV Transcription Elongation0.78
    Pausing and recovery of HIV elongation0.74
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.78
    Pausing and recovery of Tat-mediated HIV elongation0.73
    Formation of HIV elongation complex in the absence of HIV Tat0.76
    Tat-mediated HIV elongation arrest and recovery0.73
    3HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    Host Interactions of HIV factors0.60
    4Cellular response to hypoxia
    Cellular response to hypoxia0.72
    Regulation of Hypoxia-inducible Factor (HIF) by Oxygen0.72
    Cellular responses to stress0.72
    Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha0.72
    5Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TCEB1
        Common schema of ubiquitination

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCEB1
        HIF1Alpha Pathway
    JAK-STAT Pathway
    SOCS Pathway

    2 BioSystems Pathways for TCEB1
        Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
    HIF-2-alpha transcription factor network

    5/30        Reactome Pathways for TCEB1 (see all 30)
        Formation of RNA Pol II elongation complex
    Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    Late Phase of HIV Life Cycle


    4         Kegg Pathways  (Kegg details for TCEB1):
        HIF-1 signaling pathway
    Ubiquitin mediated proteolysis
    Pathways in cancer
    Renal cell carcinoma


    TCEB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCEB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/199 Interacting proteins for TCEB1 (Q153691, 2, 3 ENSP000002848114) via UniProtKB, MINT, STRING, and/or I2D (see all 199)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL2Q136172, 3, ENSP000003638804MINT-4140881 MINT-7014221 MINT-6543008 MINT-8295435 MINT-7014239 MINT-8295568 MINT-8295466 MINT-6542668 MINT-8295501 MINT-8295600 MINT-7014201 MINT-8295545 I2D: score=7 STRING: ENSP00000363880
    TCEB2Q153701, 2, 3, ENSP000002623064EBI-301231,EBI-301238 MINT-8295466 MINT-8295568 MINT-7014221 MINT-6543008 MINT-6542668 MINT-8295435 MINT-7014239 MINT-7014201 MINT-68462 MINT-8295545 I2D: score=12 STRING: ENSP00000262306
    RBX1P628772, 3, ENSP000002162254MINT-7014221 MINT-8295435 MINT-7014239 MINT-7014201 I2D: score=1 STRING: ENSP00000216225
    VHLP403372, 3, ENSP000002564744MINT-6543008 MINT-6542668 I2D: score=9 STRING: ENSP00000256474
    MED8Q96G251, 3, ENSP000002906634EBI-301231,EBI-394405 I2D: score=4 STRING: ENSP00000290663
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS7660129
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0010467gene expression TAS--

    TCEB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TCEB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCEB1 (ELOC)

    2 Novoseek inferred chemical compound relationships for TCEB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 23.3 1 9751722 (1)
    tyrosine 0 1 12783885 (1)

    Search CenterWatch for drugs/clinical trials and news about TCEB1 / ELOC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCEB1 gene (9 alternative transcripts): 
    NM_001204857.1  NM_001204858.1  NM_001204859.1  NM_001204860.1  NM_001204861.1  NM_001204862.1  NM_001204863.1  NM_001204864.1  
    NM_005648.3  

    Unigene Clusters for TCEB1:

    Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
    Hs.533437  [show with all ESTs], Hs.554594  [show with all ESTs], Hs.731928  [show with all ESTs]
    Unigene Representative Sequences: BQ222745, BF676305, NM_001204858
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602840 ENST00000518127(uc022avv.1 uc022avw.1 uc022avx.1 uc003xzy.2 uc003yaa.2 uc022avy.1 uc003xzx.2 uc022avz.1 uc003xzz.2)
    ENST00000520210 ENST00000520242 ENST00000519487 ENST00000284811 ENST00000522337
    ENST00000523815 ENST00000519082
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK057889.1 AL832244.1 BC100283.1 BX649138.1 

    16 DOTS entries:

    DT.119019  DT.100812890  DT.95156046  DT.92441087  DT.92441095  DT.121472109  DT.100812882  DT.97847956 
    DT.100032209  DT.121472106  DT.95156048  DT.95156042  DT.92441093  DT.95359771  DT.99947821  DT.100812893 

    24/333 AceView cDNA sequences (see all 333):

    BQ223002 W73389 BQ787840 AA100084 AI018025 AA759256 N89607 W81685 
    CF129635 BQ575942 BM455210 BM713029 AI744809 AA781198 AL521813 BE612839 
    AI241109 AI207475 BM709927 BQ020396 BQ001836 CA310782 AI149864 AI355589 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TCEB1 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i
    SP1:                                                  -                       -                                                         
    SP2:                          -     -     -     -     -                       -                                                         
    SP3:                          -     -     -     -     -                       -                                                         
    SP4:                          -     -     -     -           -                 -                                                         
    SP5:              -     -     -     -     -     -     -     -                 -                                                         


    ECgene alternative splicing isoforms for TCEB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCEB1 expression in normal human tissues (normalized intensities)      TCEB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTACGT
    TCEB1 Expression
    About this image


    TCEB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass

     -- (Gastrointestinal Tract)
             visceral organ/oral region/gland   

    See TCEB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCEB1

    SOURCE GeneReport for Unigene clusters: Hs.533437 Hs.554594 Hs.731928

    UniProtKB/Swiss-Prot: ELOC_HUMAN, Q15369
    Tissue specificity: Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3

        SABiosciences Expression via Pathway-Focused PCR Array including TCEB1: 
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TCEB1 gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tceb11 , 5 transcription elongation factor B (SIII), polypeptide more1, 5 92.56(n)1
    100(a)1
      1 (5.10 cM)5
    679231  NM_026456.41  NP_080732.11 
     166427665 
    chicken
    (Gallus gallus)
    Aves TCEB11 transcription elongation factor B (SIII), polypeptide more 88.99(n)
    100(a)
      420187  NM_001007888.1  NP_001007889.1 
    lizard
    (Anolis carolinensis)
    Reptilia TCEB16
    Uncharacterized protein
    99(a)
    1 ↔ 1
    4(33707821-33792786)
    African clawed frog
    (Xenopus laevis)
    Amphibia tceb1-prov2 elongation factor SIII p15 subunit 85.52(n)    BC055268.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM081014.12   -- 81.95(n)    BM081014.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Elongin-C1 , 3 transcription elongation factor3
    Elongin C1
    94(a)3
    72.22(n)1
    93.52(a)1
      56D73
    372371  NM_166354.21  NP_725894.11 
    worm
    (Caenorhabditis elegans)
    Secernentea elc-11 Protein ELC-1 63.3(n)
    76.15(a)
      190775  NM_065004.2  NP_497405.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ELC1(YPL046C)4 Elongin C, conserved among eukaryotes; forms a complex more   --   16(466943-466644) 856061  NP_015279.1 


    ENSEMBL Gene Tree for TCEB1 (if available)
    TreeFam Gene Tree for TCEB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCEB1 gene

    TCEB1 for paralogs           About GeneDecksing


    5/31 Pseudogenes.org Pseudogenes for TCEB1 (see all 31)
    PGOHUM00000238438 PGOHUM00000238675 PGOHUM00000242508 PGOHUM00000239369 PGOHUM00000239586


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/610 SNPs in TCEB1 are shown (see all 610)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819568711,2
    --74857012(+) CCATGC/TCTGAC 9 -- ds50010--------
    rs665978481,2
    C--74857097(+) ACTTG-/ATAA  
            
    ATAAT
    9 -- ds50010--------
    rs1859168301,2
    --74857140(+) CTTAAA/GAAGTT 9 -- ds50010--------
    rs47384001,2
    C,F,H--74857165(+) GGGCGC/TGCTGC 9 -- ds50017Minor allele frequency- T:0.17NS EA WA NA 776
    rs351131111,2
    C--74857349(+) TTTTT-/TGAGAC 9 -- ds50011Minor allele frequency- T:0.00NA 2
    rs1448750061,2
    --74857455(+) TCAAGC/TGATTC 9 -- ut310--------
    rs1387852261,2
    C--74857541(+) TAGAGA/GTGGGG 9 -- ut310--------
    rs1907310131,2
    --74857639(+) ATGAGA/CCACCG 9 -- ut310--------
    rs1825557691,2
    --74857692(+) AAGTTC/TATAGA 9 -- ut310--------
    rs1856486661,2
    --74857699(+) TAGACC/GCTATA 9 -- ut310--------

    HapMap Linkage Disequilibrium report for TCEB1 (74851404 - 74884522 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TCEB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831355CNV Loss17160897
    nsv510151CNV Loss20534489
    esv1009583OTHER Inversion20482838

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600788    OMIM disorders: --

    13 diseases for TCEB1:    About MalaCards
    von hippel-lindau disease    renal clear cell carcinoma    hemangioma    hypoxia
    polycythemia    renal cell carcinoma    kidney disease    colon cancer
    prostate cancer    thyroiditis    prostatitis    gastric cancer
    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for TCEB1:
    Hemangioma     Renal cell carcinoma

    TCEB1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TCEB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 57.5 2 10722748 (1), 9751722 (1)
    tumors 37.5 5 9341197 (3), 17922844 (1)
    cancer 3.46 1 8812434 (1)

    Genetic Association Database (GAD): TCEB1
    Human Genome Epidemiology (HuGE) Navigator: TCEB1 (1 document)

    Export disorders for TCEB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCEB1 gene, integrated from 9 sources (see all 197):
    (articles sorted by number of sources associating them with TCEB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human cDNA encoding the small subunit of RNA polymerase II transcription factor SIII. (PubMed id 7821821)1, 2, 3 Garrett K.P.... Conaway J.W. (1994)
    2. Inhibition of transcription elongation by the VHL tumor suppressor protein. (PubMed id 7660122)1, 3, 9 Duan D.R....Klausner R.D. (1995)
    3. Amplification and overexpression of Elongin C gene discovered in prostate cancer by cDNA microarrays. (PubMed id 12004003)1, 2, 9 Porkka K.... Visakorpi T. (2002)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. (PubMed id 15574592)1, 2 Mehle A.... Gabuzda D. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling. (PubMed id 12004076)1, 2 Min J.-H....Pavletich N.P. (2002)
    8. Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. (PubMed id 12050673)1, 2 Hon W.-C.... Jones E.Y. (2002)
    9. Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity. (PubMed id 11006129)1, 2 Aso T.... Kitajima S. (2000)
    10. Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. (PubMed id 10205047)1, 2 Stebbins C.E.... Pavletich N.P. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6921 HGNC: 11617 AceView: TCEB1 Ensembl:ENSG00000154582 euGenes: HUgn6921
    ECgene: TCEB1 Kegg: 6921 H-InvDB: TCEB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCEB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TCEB1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCEB1 gene:
    Search GeneIP for patents involving TCEB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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