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Aliases for TCEB1 Gene

Aliases for TCEB1 Gene

  • Transcription Elongation Factor B Subunit 1 2 3
  • Transcription Elongation Factor B (SIII), Polypeptide 1 (15kDa, Elongin C) 2 3 5
  • RNA Polymerase II Transcription Factor SIII Subunit C 3 4
  • Elongin 15 KDa Subunit 3 4
  • Elongin C 2 3
  • SIII P15 3 4
  • EloC 3 4
  • Transcription Elongation Factor B (SIII), Polypeptide 1 (15kD, Elongin C) 2
  • Elongin-C 4
  • SIII 3

External Ids for TCEB1 Gene

Previous GeneCards Identifiers for TCEB1 Gene

  • GC08M074797
  • GC08M074580
  • GC08M074907
  • GC08M075019
  • GC08M074858
  • GC08M070349

Summaries for TCEB1 Gene

Entrez Gene Summary for TCEB1 Gene

  • This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

GeneCards Summary for TCEB1 Gene

TCEB1 (Transcription Elongation Factor B Subunit 1) is a Protein Coding gene. Diseases associated with TCEB1 include Renal Cell Carcinoma and Hiv-1. Among its related pathways are Formation of the HIV-1 Early Elongation Complex and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include protein complex binding.

UniProtKB/Swiss-Prot for TCEB1 Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

  • The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Gene Wiki entry for TCEB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEB1 Gene

Genomics for TCEB1 Gene

Regulatory Elements for TCEB1 Gene


Promoters for TCEB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCEB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCEB1 Gene

Chromosome:
8
Start:
73,939,169 bp from pter
End:
73,972,287 bp from pter
Size:
33,119 bases
Orientation:
Minus strand

Genomic View for TCEB1 Gene

Genes around TCEB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEB1 Gene

Proteins for TCEB1 Gene

  • Protein details for TCEB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15369-ELOC_HUMAN
    Recommended name:
    Transcription elongation factor B polypeptide 1
    Protein Accession:
    Q15369
    Secondary Accessions:
    • E5RGD9
    • Q567Q6

    Protein attributes for TCEB1 Gene

    Size:
    112 amino acids
    Molecular mass:
    12473 Da
    Quaternary structure:
    • Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, TCEB3, VHL or WSB1. The elongin BC complex is part of a complex with hydroxylated HIF1A. Substrate adapter protein can be a viral protein such as HIV Vif. Interacts with VHL. Interacts with TMF1. Interacts with human respiratory syncytial virus (HRSV) protein NS1. Interacts with SPSB1. posed of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2. Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component.

    Three dimensional structures from OCA and Proteopedia for TCEB1 Gene

    Alternative splice isoforms for TCEB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEB1 Gene

Proteomics data for TCEB1 Gene at MOPED

Post-translational modifications for TCEB1 Gene

  • Ubiquitination at Lys 6, Lys 32, and Lys 43
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TCEB1 Gene

Domains & Families for TCEB1 Gene

Protein Domains for TCEB1 Gene

Suggested Antigen Peptide Sequences for TCEB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15369

UniProtKB/Swiss-Prot:

ELOC_HUMAN :
  • Belongs to the SKP1 family.
Family:
  • Belongs to the SKP1 family.
genes like me logo Genes that share domains with TCEB1: view

No data available for Gene Families for TCEB1 Gene

Function for TCEB1 Gene

Molecular function for TCEB1 Gene

GENATLAS Biochemistry:
elongin C,15kDa,regulatory subunit of the transcription elongation factor B (SIII),complex SIII,polypeptide 1 (see TCEB3). Also complexing with TCEB2,CUL2 and VHL to form the VCB-CUL2 complex (see VHL)
UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
UniProtKB/Swiss-Prot Function:
The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Gene Ontology (GO) - Molecular Function for TCEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with TCEB1: view
genes like me logo Genes that share phenotypes with TCEB1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEB1 Gene

Localization for TCEB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEB1 Gene COMPARTMENTS Subcellular localization image for TCEB1 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TCEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TCEB1: view

Pathways & Interactions for TCEB1 Gene

genes like me logo Genes that share pathways with TCEB1: view

SIGNOR curated interactions for TCEB1 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for TCEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 7660129
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0016032 viral process IEA,TAS --
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IBA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with TCEB1: view

Drugs & Compounds for TCEB1 Gene

(1) Drugs for TCEB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TCEB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TCEB1: view

Transcripts for TCEB1 Gene

Unigene Clusters for TCEB1 Gene

Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCEB1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i
SP1: - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - -
SP7: - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - -
SP11:

Relevant External Links for TCEB1 Gene

GeneLoc Exon Structure for
TCEB1
ECgene alternative splicing isoforms for
TCEB1

Expression for TCEB1 Gene

mRNA expression in normal human tissues for TCEB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TCEB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCEB1 Gene



SOURCE GeneReport for Unigene cluster for TCEB1 Gene Hs.533437

mRNA Expression by UniProt/SwissProt for TCEB1 Gene

Q15369-ELOC_HUMAN
Tissue specificity: Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3.
genes like me logo Genes that share expression patterns with TCEB1: view

Protein tissue co-expression partners for TCEB1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for TCEB1 Gene

Orthologs for TCEB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TCEB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TCEB1 35
  • 94.05 (n)
  • 100 (a)
TCEB1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCEB1 35
  • 94.64 (n)
  • 100 (a)
TCEB1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tceb1 35
  • 92.56 (n)
  • 100 (a)
Tceb1 16
Tceb1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TCEB1 35
  • 99.4 (n)
  • 100 (a)
TCEB1 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tceb1 35
  • 93.75 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia TCEB1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCEB1 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCEB1 35
  • 88.99 (n)
  • 100 (a)
TCEB1 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCEB1 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2774 35
tceb1 35
  • 85.42 (n)
  • 100 (a)
African clawed frog
(Xenopus laevis)
Amphibia tceb1-prov 35
zebrafish
(Danio rerio)
Actinopterygii tceb1b 35
  • 80.95 (n)
  • 99.11 (a)
tceb1b 36
  • 99 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2905 35
fruit fly
(Drosophila melanogaster)
Insecta Elongin-C 37
  • 94 (a)
Elongin-C 35
  • 72.22 (n)
  • 93.52 (a)
Elongin-C 36
  • 86 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011535 35
  • 74.24 (n)
  • 95.45 (a)
worm
(Caenorhabditis elegans)
Secernentea elc-1 35
  • 63.03 (n)
  • 75.45 (a)
elc-1 36
  • 67 (a)
OneToMany
elc-2 36
  • 31 (a)
OneToMany
F54F7.10 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ELC1 36
  • 37 (a)
OneToOne
ELC1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G59140 35
  • 50.74 (n)
  • 46.67 (a)
rice
(Oryza sativa)
Liliopsida Os11g0707700 35
  • 51.06 (n)
  • 48.94 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14780 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2870 36
  • 82 (a)
OneToOne
Species with no ortholog for TCEB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCEB1 Gene

ENSEMBL:
Gene Tree for TCEB1 (if available)
TreeFam:
Gene Tree for TCEB1 (if available)

Paralogs for TCEB1 Gene

genes like me logo Genes that share paralogs with TCEB1: view

No data available for Paralogs for TCEB1 Gene

Variants for TCEB1 Gene

Sequence variations from dbSNP and Humsavar for TCEB1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2433208 -- 73,965,116(-) TGTGA(A/G)TATTT intron-variant
rs7830335 -- 73,949,249(+) ACTGC(A/G)GGACT intron-variant
rs7833070 -- 73,959,072(+) agagt(A/T)aaaaa intron-variant
rs7838628 -- 73,956,486(+) AGTCA(C/T)CAAGA intron-variant
rs2929504 -- 73,971,051(-) ttttc(C/T)ttttt intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TCEB1 Gene

Variant ID Type Subtype PubMed ID
nsv831355 CNV Loss 17160897
nsv510151 CNV Loss 20534489
esv1009583 OTHER Inversion 20482838

Variation tolerance for TCEB1 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TCEB1 Gene

Disorders for TCEB1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TCEB1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
hiv-1
  • aids, slow progression to
renal clear cell carcinoma
  • clear cell carcinoma of kidney
familial renal papillary carcinoma
  • hereditary papillary renal carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search TCEB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCEB1

Genetic Association Database (GAD)
TCEB1
Human Genome Epidemiology (HuGE) Navigator
TCEB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEB1
genes like me logo Genes that share disorders with TCEB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCEB1 Gene

Publications for TCEB1 Gene

  1. A human cDNA encoding the small subunit of RNA polymerase II transcription factor SIII. (PMID: 7821821) Garrett K.P. … Conaway J.W. (Gene 1994) 2 3 4 67
  2. Inhibition of transcription elongation by the VHL tumor suppressor protein. (PMID: 7660122) Duan D.R. … Klausner R.D. (Science 1995) 2 3 23
  3. Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B. (PMID: 20086098) Li X.S. … Tanese N. (Mol. Cell. Biol. 2010) 3 23
  4. Array MAPPIT: high-throughput interactome analysis in mammalian cells. (PMID: 19159283) Lievens S. … Tavernier J. (J. Proteome Res. 2009) 3 23
  5. Regulation of DNA topoisomerase IIalpha stability by the ECV ubiquitin ligase complex. (PMID: 19695223) Yun J. … Choi C.H. (Biochem. Biophys. Res. Commun. 2009) 3 23

Products for TCEB1 Gene

Sources for TCEB1 Gene

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