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Aliases for TCEB1 Gene

Aliases for TCEB1 Gene

  • Transcription Elongation Factor B (SIII), Polypeptide 1 (15kDa, Elongin C) 2 3
  • RNA Polymerase II Transcription Factor SIII Subunit C 3 4
  • Elongin 15 KDa Subunit 3 4
  • SIII P15 3 4
  • EloC 3 4
  • Transcription Elongation Factor B (SIII), Polypeptide 1 (15kD, Elongin C) 2
  • Transcription Elongation Factor B Polypeptide 1 3
  • Elongin-C 4
  • SIII 3

External Ids for TCEB1 Gene

Summaries for TCEB1 Gene

Entrez Gene Summary for TCEB1 Gene

  • This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

GeneCards Summary for TCEB1 Gene

TCEB1 (Transcription Elongation Factor B (SIII), Polypeptide 1 (15kDa, Elongin C)) is a Protein Coding gene. Diseases associated with TCEB1 include hiv-1. Among its related pathways are TGF-Beta Pathway and Disease. GO annotations related to this gene include protein complex binding.

UniProtKB/Swiss-Prot for TCEB1 Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

  • The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Gene Wiki entry for TCEB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEB1 Gene

Genomics for TCEB1 Gene

Genomic Location for TCEB1 Gene

Start:
73,939,169 bp from pter
End:
73,972,287 bp from pter
Size:
33,119 bases
Orientation:
Minus strand

Genomic View for TCEB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEB1 Gene

Regulatory Elements for TCEB1 Gene

Proteins for TCEB1 Gene

  • Protein details for TCEB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15369-ELOC_HUMAN
    Recommended name:
    Transcription elongation factor B polypeptide 1
    Protein Accession:
    Q15369
    Secondary Accessions:
    • E5RGD9
    • Q567Q6

    Protein attributes for TCEB1 Gene

    Size:
    112 amino acids
    Molecular mass:
    12473 Da
    Quaternary structure:
    • Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, TCEB3, VHL or WSB1. The elongin BC complex is part of a complex with hydroxylated HIF1A. Substrate adapter protein can be a viral protein such as HIV Vif. Interacts with VHL. Interacts with TMF1. Interacts with human respiratory syncytial virus (HRSV) protein NS1. Interacts with SPSB1. posed of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2. Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component.

    Three dimensional structures from OCA and Proteopedia for TCEB1 Gene

    Alternative splice isoforms for TCEB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEB1 Gene

Proteomics data for TCEB1 Gene at MOPED

Post-translational modifications for TCEB1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys32 and Lys43

No data available for DME Specific Peptides for TCEB1 Gene

Domains for TCEB1 Gene

Protein Domains for TCEB1 Gene

Suggested Antigen Peptide Sequences for TCEB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15369

UniProtKB/Swiss-Prot:

ELOC_HUMAN
Family:
  • Belongs to the SKP1 family.:
    • Q15369
genes like me logo Genes that share domains with TCEB1: view

No data available for Gene Families for TCEB1 Gene

Function for TCEB1 Gene

Molecular function for TCEB1 Gene

GENATLAS Biochemistry: elongin C,15kDa,regulatory subunit of the transcription elongation factor B (SIII),complex SIII,polypeptide 1 (see TCEB3). Also complexing with TCEB2,CUL2 and VHL to form the VCB-CUL2 complex (see VHL)
UniProtKB/Swiss-Prot Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
UniProtKB/Swiss-Prot Function: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Gene Ontology (GO) - Molecular Function for TCEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10205047
GO:0032403 protein complex binding --
genes like me logo Genes that share ontologies with TCEB1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TCEB1 Gene

Localization for TCEB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEB1 Gene COMPARTMENTS Subcellular localization image for TCEB1 gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TCEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0030891 VCB complex --
GO:0070449 elongin complex IEA --
genes like me logo Genes that share ontologies with TCEB1: view

Pathways for TCEB1 Gene

genes like me logo Genes that share pathways with TCEB1: view

Gene Ontology (GO) - Biological Process for TCEB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 7660129
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with TCEB1: view

Compounds for TCEB1 Gene

(2) Novoseek inferred chemical compound relationships for TCEB1 Gene

Compound -log(P) Hits PubMed IDs
vegf 23.3 1
tyrosine 0 1
genes like me logo Genes that share compounds with TCEB1: view

Transcripts for TCEB1 Gene

Unigene Clusters for TCEB1 Gene

Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCEB1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i
SP1: - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - -
SP7: - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - -
SP11:

Relevant External Links for TCEB1 Gene

GeneLoc Exon Structure for
TCEB1
ECgene alternative splicing isoforms for
TCEB1

Expression for TCEB1 Gene

mRNA expression in normal human tissues for TCEB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCEB1 Gene

SOURCE GeneReport for Unigene cluster for TCEB1 Gene Hs.533437

mRNA Expression by UniProt/SwissProt for TCEB1 Gene

Q15369-ELOC_HUMAN
Tissue specificity: Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3.
genes like me logo Genes that share expressions with TCEB1: view

No data available for mRNA differential expression in normal tissues for TCEB1 Gene

Orthologs for TCEB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TCEB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEB1 35
  • 99.4 (n)
  • 100 (a)
TCEB1 36
  • 60 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCEB1 35
  • 94.05 (n)
  • 100 (a)
TCEB1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCEB1 35
  • 94.64 (n)
  • 100 (a)
TCEB1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tceb1 35
  • 92.56 (n)
  • 100 (a)
Tceb1 16
Tceb1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCEB1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCEB1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tceb1 35
  • 93.75 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves TCEB1 35
  • 88.99 (n)
  • 100 (a)
TCEB1 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCEB1 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tceb1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2774 35
tceb1 35
  • 85.42 (n)
  • 100 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2905 35
zebrafish
(Danio rerio)
Actinopterygii tceb1b 35
  • 80.95 (n)
  • 99.11 (a)
tceb1b 36
  • 99 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011535 35
  • 74.24 (n)
  • 95.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Elongin-C 35
  • 72.22 (n)
  • 93.52 (a)
Elongin-C 36
  • 86 (a)
OneToOne
Elongin-C 37
  • 94 (a)
worm
(Caenorhabditis elegans)
Secernentea elc-1 35
  • 63.03 (n)
  • 75.45 (a)
elc-1 36
  • 67 (a)
OneToMany
elc-2 36
  • 31 (a)
OneToMany
F54F7.10 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ELC1 36
  • 37 (a)
OneToOne
ELC1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G59140 35
  • 50.74 (n)
  • 46.67 (a)
rice
(Oryza sativa)
Liliopsida Os11g0707700 35
  • 51.06 (n)
  • 48.94 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14780 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2870 36
  • 82 (a)
OneToOne
Species with no ortholog for TCEB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCEB1 Gene

ENSEMBL:
Gene Tree for TCEB1 (if available)
TreeFam:
Gene Tree for TCEB1 (if available)

Paralogs for TCEB1 Gene

genes like me logo Genes that share paralogs with TCEB1: view

No data available for Paralogs for TCEB1 Gene

Variants for TCEB1 Gene

Sequence variations from dbSNP and Humsavar for TCEB1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs900130 -- 73,958,864(+) ggcaa(C/T)cttat intron-variant
rs900131 -- 73,959,089(+) CCTGT(A/G)TAGGG intron-variant
rs922752 -- 73,950,582(+) taatc(A/C)caatg intron-variant
rs1060663 -- 73,946,677(-) CACCT(C/G)AAATT missense, reference
rs1277916 -- 73,951,820(+) gtgtg(G/T)tactg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCEB1 Gene

Variant ID Type Subtype PubMed ID
nsv831355 CNV Loss 17160897
nsv510151 CNV Loss 20534489
esv1009583 OTHER Inversion 20482838

Relevant External Links for TCEB1 Gene

HapMap Linkage Disequilibrium report
TCEB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCEB1 Gene

Disorders for TCEB1 Gene

(1) MalaCards Diseases for TCEB1 Gene

Search for TCEB1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for TCEB1 Gene

(3) Novoseek inferred disease relationships for TCEB1 Gene

Disease -log(P) Hits PubMed IDs
carcinoma renal cell 57.5 2
tumors 37.5 4
cancer 3.46 1

Relevant External Links for TCEB1

Genetic Association Database (GAD)
TCEB1
Human Genome Epidemiology (HuGE) Navigator
TCEB1
genes like me logo Genes that share disorders with TCEB1: view

No data available for UniProtKB/Swiss-Prot for TCEB1 Gene

Publications for TCEB1 Gene

  1. Inhibition of transcription elongation by the VHL tumor suppressor protein. (PMID: 7660122) Duan D.R. … Klausner R.D. (Science 1995) 2 3 23
  2. Amplification and overexpression of Elongin C gene discovered in prostate cancer by cDNA microarrays. (PMID: 12004003) Porkka K. … Visakorpi T. (Lab. Invest. 2002) 3 4 23
  3. A human cDNA encoding the small subunit of RNA polymerase II transcription factor SIII. (PMID: 7821821) Garrett K.P. … Conaway J.W. (Gene 1994) 2 3 4
  4. Regulation of DNA topoisomerase IIalpha stability by the ECV ubiquitin ligase complex. (PMID: 19695223) Yun J. … Choi C.H. (Biochem. Biophys. Res. Commun. 2009) 3 23
  5. Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B. (PMID: 20086098) Li X.S. … Tanese N. (Mol. Cell. Biol. 2010) 3 23

Products for TCEB1 Gene

Sources for TCEB1 Gene

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