TCEB1 Gene
protein-coding GIFtS: 60
GCID: GC08M074858
|
|
transcription elongation factor B (SIII), polypeptide 1...(Previous names: transcription elongation factor B (SIII), polypeptide 1...)
| |
Aliases
for TCEB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transcription Elongation Factor B (SIII), Polypeptide 1 (15kDa, ElonginC)1 2 | | EloC3 | | SIII1 2 | | Elongin-C3 | | Elongin 15 KDa Subunit2 3 | | Transcription Elongation Factor B Polypeptide 12 | | RNA Polymerase II Transcription Factor SIII Subunit C2 3 | | Transcription Elongation Factor B, Polypeptide 12 | | SIII P152 3 | | EloC3 | | Transcription Elongation Factor B (SIII), Polypeptide 1 (15kD, Elongin C)1 | | Elongin-C3 |
Export aliases for TCEB1 gene to outside databasesPrevious GC identifers: GC08M073910 GC08M074797 GC08M074580 GC08M074907 GC08M075019 GC08M070349 |
Summaries
for TCEB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TCEB1:
This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIIIcomplex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transientpausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionallyactive component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specificallyexpressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumorsuppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternativelyspliced transcript variants encoding two distinct isoforms have been identified. (provided by RefSeq, Mar 2011)
UniProtKB/Swiss-Prot: ELOC_HUMAN, Q15369Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymeraseII transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and itstranscription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C(elongin BC complex)Function: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of targetproteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL).By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family,to Cullin/RBX1 modules that activate E2 ubiquitination enzymes
Gene Wiki entry for TCEB1
|
Genomic Views
for TCEB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TCEB1 gene promoter:
TBP STAT1 AML1a AP-1 ATF-2 IRF-1 MZF-1 c-Jun Msx-1 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCEB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q21.11 Ensembl cytogenetic band: 8q21.11 HGNC cytogenetic band: 8q13.3TCEB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M074858: view genomic region
(about GC identifiers)
Start:
|
74,857,354 bp from pter |
End:
|
74,884,522 bp from pter |
Size:
|
27,169 bases |
Orientation:
|
minus strand |
|
Proteins
for TCEB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ELOC_HUMAN, Q15369 (See
protein sequence)Recommended Name: Transcription elongation factor B polypeptide 1 Size: 112 amino acids; 12473 Da
Subunit: Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2,RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, TCEB3, VHL or WSB1 (By similarity). The elonginBC complex is part of a complex with hydroxylated HIF1A. Substrate adapter protein can be a viral protein such as HIVVif. Interacts with VHL. Interacts with TMF1. Interacts with human respiratory syncytial virus (HRSV) protein NS1
Subcellular location: Nucleus (Probable)
6/16 PDB 3D structures from  and Proteopedia  for TCEB1 (see all 16):1LM8 (3D)
1LQB (3D)
1VCB (3D)
2C9W (3D)
2IZV (3D)
3DCG (3D)
Secondary accessions: E5RGD9 Q567Q6Alternative splicing: 2 isoforms: Q15369-1 Q15369-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TCEB1: NX_Q15369
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15369
TCEB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (9 alternative transcripts):
NP_001191786.1 NP_001191787.1 NP_001191788.1 NP_001191789.1 NP_001191790.1 NP_001191791.1 NP_001191792.1 NP_001191793.1 NP_005639.1
ENSEMBL proteins: ENSP00000428334 ENSP00000430224 ENSP00000428171 ENSP00000429596 ENSP00000284811 ENSP00000429906 ENSP00000428074 ENSP00000429789 ENSP00000429187 Reactome Protein details: Q15369
Human Recombinant Protein Products for TCEB1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TCEB1 for ontologies About GeneDecksing
TCEB1 Antibody Products:
Assay Products for TCEB1: |
Protein
Domains /
Families
for TCEB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCEB1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15369ProtoNet protein and cluster: Q15369 UniProtKB/Swiss-Prot: ELOC_HUMAN, Q15369Similarity: Belongs to the SKP1 family |
Function
for TCEB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ELOC_HUMAN, Q15369Function: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymeraseII transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and itstranscription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C(elongin BC complex)Function: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of targetproteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL).By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family,to Cullin/RBX1 modules that activate E2 ubiquitination enzymes Genatlas biochemistry entry for TCEB1:elongin C,15kDa,regulatory subunit of the transcription elongation factor B (SIII),complex SIII,polypeptide 1 (seeTCEB3). Also complexing with TCEB2,CUL2 and VHL to form the VCB-CUL2 complex (see VHL)
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0032403 | protein complex binding |
IEA | -- |
TCEB1 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCEB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEB1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 9): TCEB1 (NM_001204859) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCEB1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEB1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEB1 |
|
Pathways & Interactions
for TCEB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Formation of RNA Pol II elongation complex | | | 2 | Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha | | | 3 | Antigen processing: Ubiquitination & Proteasome degradation | | | 4 | Immune System | | | 5 | Late Phase of HIV Life Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TCEB1
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TCEB1
2  BioSystems Pathways for TCEB1
5/34 
Reactome Pathways for TCEB1 (see all 34)
3 
Kegg Pathways (Kegg details for TCEB1):
TCEB1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCEB1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/199 Interacting proteins for TCEB1 (Q153691, 2, 3 ENSP000002848114) via UniProtKB, MINT, STRING, and/or I2D (see all 199)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CUL2 | Q136172, 3, ENSP000003638804 | MINT-4140881 MINT-7014221 MINT-6543008 MINT-8295435 MINT-7014239 MINT-8295568 MINT-8295466 MINT-6542668 MINT-8295501 MINT-8295600 MINT-7014201 MINT-8295545 I2D:
score=7 STRING: ENSP00000363880 | | TCEB2 | Q153701, 2, 3, ENSP000002623064 | EBI-301231,EBI-301238 MINT-8295466 MINT-8295568 MINT-7014221 MINT-6543008 MINT-6542668 MINT-8295435 MINT-7014239 MINT-7014201 MINT-68462 MINT-8295545 I2D:
score=12 STRING: ENSP00000262306 | | RBX1 | P628772, 3, ENSP000002162254 | MINT-7014221 MINT-8295435 MINT-7014239 MINT-7014201 I2D:
score=1 STRING: ENSP00000216225 | | VHL | P403372, 3, ENSP000002564744 | MINT-6543008 MINT-6542668 I2D:
score=9 STRING: ENSP00000256474 | | MED8 | Q96G251, 3, ENSP000002906634 | EBI-301231,EBI-394405 I2D:
score=4 STRING: ENSP00000290663 |
About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006357 | regulation of transcription from RNA polymerase II promoter |
TAS | 7660129 | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | -- | | GO:0006368 | transcription elongation from RNA polymerase II promoter |
TAS | -- | | GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- | | GO:0010467 | gene expression |
TAS | -- |
TCEB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TCEB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TCEB1 for compounds About GeneDecksing
 Browse Tocris compounds for TCEB1
2 Novoseek chemical compound relationships for TCEB1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| vegf |
23.3 |
1 |
9751722 (1) |
| tyrosine |
0 |
1 |
12783885 (1) |
Search CenterWatch for drugs/clinical trials and news about TCEB1 / ELOC
|
Transcripts
for TCEB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCEB1 gene (9 alternative transcripts): NM_001204857.1 NM_001204858.1 NM_001204859.1 NM_001204860.1 NM_001204861.1 NM_001204862.1 NM_001204863.1 NM_001204864.1 NM_005648.3 Unigene Clusters for TCEB1: Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) Hs.533437 [show with all ESTs], Hs.554594 [show with all ESTs], Hs.731928 [show with all ESTs]Unigene Representative Sequences: BQ222745, BF676305, NM_0012048589 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000518127(uc022avv.1 uc022avw.1 uc022avx.1 uc003xzy.2 uc003yaa.2 uc022avy.1 uc003xzx.2 uc022avz.1 uc003xzz.2)
ENST00000520210 ENST00000520242 ENST00000519487 ENST00000284811 ENST00000522337
ENST00000523815 ENST00000519082 ENST00000519021
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCEB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEB1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 9): TCEB1 (NM_001204859) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCEB1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEB1 |
Additional cDNA sequence: AK057889.1 AL832244.1 BC100283.1 BX649138.1 16 DOTS entries: DT.119019 DT.100812890 DT.95156046 DT.92441087 DT.92441095 DT.121472109 DT.100812882 DT.97847956 DT.100032209 DT.121472106 DT.95156048 DT.95156042 DT.92441093 DT.95359771 DT.99947821 DT.100812893 24/333 AceView cDNA sequences (see all 333): BM713029 AW135664 BM455210 AI088438 BI467064 BM716893 CR603697 AI601114 AA262706 AA058819 BG164174 NM_005648 AA887624 AA037450 AA573315 BM757257 AI355589 BG944103 BM469544 AA769423 BE612839 W63784 AI085496 CR602773
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TCEB1 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | · | 10g | · | 10h | · | 10i |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TCEB1
|
Expression
for TCEB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCEB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTTACGT
About this image
See TCEB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCEB1
SOURCE GeneReport for Unigene clusters: Hs.533437 Hs.554594 Hs.731928
UniProtKB/Swiss-Prot: ELOC_HUMAN, Q15369Tissue specificity: Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3
SABiosciences Expression via Pathway-Focused PCR Array including TCEB1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCEB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TCEB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCEB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEB1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEB1 |
Orthologs
for TCEB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TCEB1 gene from 9/30 species (see all 30) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tceb11 , 5 |
transcription elongation factor B (SIII), polypeptide more1, 5 |
92.56(n)1
100(a)1 |
|
1 (5.10 cM)5
679231 NM_026456.41 NP_080732.11
166427665 |
chicken
(Gallus gallus) |
Aves |
TCEB11 |
transcription elongation factor B (SIII), polypeptide more |
88.99(n)
100(a) |
|
420187 NM_001007888.1 NP_001007889.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TCEB16 |
-- |
99(a) |
1 ↔ 1 |
4(33791205-33792786) |
African clawed frog
(Xenopus laevis) |
Amphibia |
tceb1-prov2 |
elongation factor SIII p15 subunit |
85.52(n) |
|
BC055268.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BM081014.12 |
-- |
81.95(n) |
|
BM081014.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Elongin-C1 , 3 |
transcription elongation factor3
Elongin C1 |
94(a)3
72.22(n)1
93.52(a)1 |
|
56D73
372371 NM_166354.21 NP_725894.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
elc-11 |
Protein ELC-1 |
63.3(n)
76.15(a) |
|
190775 NM_065004.2 NP_497405.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G591406 |
transcription elongation factor B, polypeptide 1 |
44(a) |
1 ↔ 1 |
5(23874411-23875695) |
rice
(Oryza sativa) |
Liliopsida |
-- |
skp1 family, tetramerisation domain containing pro... |
37(a) |
1 ↔ 1 |
11(28434679-28437876) |
ENSEMBL Gene Tree for TCEB1 (if available)
TreeFam Gene Tree for TCEB1 (if available) |
Paralogs
for TCEB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TCEB1 gene
18/59 SIMAP similar genes for TCEB1 using alignment to 3 protein entries: ELOC_HUMAN (see all proteins)
(see all similar genes):DNMT1 EML2 ZNF74 APOD AURA2 ZNF585B
ARF3 BTBD2 WARS FAM210A FOPNL BECN1
C4orf22 CATSPERG HMGA2 ZNF212 ZNF564 DCTN5
TCEB1 for paralogs About GeneDecksing
5/31 Pseudogenes.org Pseudogenes for TCEB1 (see all 31)
PGOHUM00000238438 PGOHUM00000238675 PGOHUM00000242508 PGOHUM00000239369 PGOHUM00000239586
|
Genomic Variants
for TCEB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TCEB1 (74857354 - 74884522 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TCEB1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCEB1 |
|
Disorders
/ Diseases
for TCEB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCEB1 for disorders About GeneDecksing
OMIM gene information: 600788
OMIM disorders: --
13  diseases for TCEB1: About MalaCardsvon hippel-lindau disease renal clear cell carcinoma renal cell carcinoma hemangioma
kidney disease colon cancer carcinoma prostate cancer
breast cancer hypoxia prostatitis immunodeficiency
thyroiditis
2 diseases from the University of Copenhagen DISEASES database for TCEB1:Hemangioma Renal cell carcinoma 3 Novoseek disease relationships for TCEB1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| carcinoma renal cell |
57.5 |
2 |
10722748 (1), 9751722 (1) |
| tumors |
37.5 |
5 |
9341197 (3), 17922844 (1) |
| cancer |
3.46 |
1 |
8812434 (1) |
Human Genome Epidemiology (HuGE) Navigator: TCEB1 (1 document)
Export disorders for TCEB1 gene to outside databases
|
Publications
for TCEB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCEB1 gene, integrated from 9 sources (see all 185):
(articles sorted by number of sources associating them with TCEB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A human cDNA encoding the small subunit of RNA polymerase II transcription factor SIII. (PubMed id 7821821)1, 2, 3 Garrett K.P.... Conaway J.W. (1994)
- Inhibition of transcription elongation by the VHL tumor suppressor protein. (PubMed id 7660122)1, 3, 9 Duan D.R....Klausner R.D. (1995)
- Amplification and overexpression of Elongin C gene discovered in prostate cancer by cDNA microarrays. (PubMed id 12004003)1, 2, 9 Porkka K.... Visakorpi T. (2002)
- Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. (PubMed id 15574592)1, 2 Mehle A.... Gabuzda D. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling. (PubMed id 12004076)1, 2 Min J.-H....Pavletich N.P. (2002)
- Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. (PubMed id 12050673)1, 2 Hon W.-C.... Jones E.Y. (2002)
- Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity. (PubMed id 11006129)1, 2 Aso T.... Kitajima S. (2000)
- Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. (PubMed id 10205047)1, 2 Stebbins C.E.... Pavletich N.P. (1999)
- Ternary complex formation of pVHL, elongin B and elongin C visualized in living cells by a fluorescence resonance energy transfer-fluorescence lifetime imaging microscopy technique. (PubMed id 17922844)1, 9 Kinoshita K....Sogawa K. (2007)
|
External Searches for TCEB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TCEB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCEB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCEB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TCEB1 gene:
Search GeneIP for patents involving TCEB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCEB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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