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TCEANC2 Gene

protein-coding   GIFtS: 38
GCID: GC01P054520

Transcription Elongation Factor A (SII) N-Terminal And Central...

(Previous name: chromosome 1 open reading frame 83)
(Previous symbol: C1orf83)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Elongation Factor A (SII) N-Terminal And Central Domain
Containing 21 2
C1orf831 2 3
Chromosome 1 Open Reading Frame 831
Transcription Elongation Factor A N-Terminal And Central Domain-Containing
Protein 22

External Ids:    HGNC: 264941   Entrez Gene: 1274282   Ensembl: ENSG000001162057   UniProtKB: Q96MN53   

Export aliases for TCEANC2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TCEANC2 Gene:
TCEANC2 (transcription elongation factor A (SII) N-terminal and central domain containing 2) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TCEANC2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TCEANC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCEANC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

TCEANC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEANC2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P054520:  view genomic region     (about GC identifiers)

Start:
54,519,260 bp from pter      End:
54,578,192 bp from pter
Size:
58,933 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TEAN2_HUMAN, Q96MN5 (See protein sequence)
Recommended Name: Transcription elongation factor A N-terminal and central domain-containing protein 2  
Size: 208 amino acids; 24150 Da
Sequence caution: Sequence=CAI22668.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q5T702 Q8N8N2
Alternative splicing: 2 isoforms:  Q96MN5-1   Q96MN5-2   

Explore the universe of human proteins at neXtProt for TCEANC2: NX_Q96MN5

Explore proteomics data for TCEANC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TCEANC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_694580.1  
    ENSEMBL proteins: 
     ENSP00000234827   ENSP00000360382  

    TCEANC2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TCEANC2

     
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    Search for Antibodies for TCEANC2 at Abcam
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    LSBio Antibodies in human, mouse, rat for TCEANC2

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    Search eBioscience for ELISAs for TCEANC2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003618 TFIIS_cen_dom
     IPR017923 TFIIS_N

    Graphical View of Domain Structure for InterPro Entry Q96MN5

    ProtoNet protein and cluster: Q96MN5

    UniProtKB/Swiss-Prot: TEAN2_HUMAN, Q96MN5
    Similarity: Belongs to the TCEANC2 family
    Similarity: Contains 1 TFIIS central domain
    Similarity: Contains 1 TFIIS N-terminal domain


    Find genes that share domains with TCEANC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    Find genes that share ontologies with TCEANC2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCEANC2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCEANC2
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    miRNA
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    Block miRNA regulation of human, mouse, rat TCEANC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TCEANC2 (see all 83):
    hsa-miR-579 hsa-miR-607 hsa-miR-4272 hsa-miR-128 hsa-miR-632 hsa-miR-298 hsa-miR-149 hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidTCEANC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TCEANC2
    Predesigned siRNA for gene silencing in human, mouse, rat TCEANC2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TCEANC2 (NM_153035)
    Sino Biological Human cDNA Clone for TCEANC2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEANC2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEANC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TEAN2_HUMAN, Q96MN5: Nucleus (By similarity)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with TCEANC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCEANC2
    Interactions:

        Search GeneGlobe Interaction Network for TCEANC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TCEANC2 (ENSP000002348274) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUPT4H1ENSP000002255044STRING: ENSP00000225504
    USP10ENSP000002194734STRING: ENSP00000219473
    ZNHIT1ENSP000003045934STRING: ENSP00000304593
    VPS72ENSP000003578874STRING: ENSP00000357887
    PFDN5ENSP000003341884STRING: ENSP00000334188
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--

    Find genes that share ontologies with TCEANC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCEANC2 (TEAN2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TCEANC2 gene: 
    NM_153035.1  

    Unigene Cluster for TCEANC2:

    Transcription elongation factor A (SII) N-terminal and central domain containing 2
    Hs.558618  [show with all ESTs]
    Unigene Representative Sequence: AK056674
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498272(uc001cwu.1) ENST00000234827(uc001cwt.1) ENST00000371331

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TCEANC2 (see all 83):
    hsa-miR-579 hsa-miR-607 hsa-miR-4272 hsa-miR-128 hsa-miR-632 hsa-miR-298 hsa-miR-149 hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidTCEANC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TCEANC2
    Predesigned siRNA for gene silencing in human, mouse, rat TCEANC2
    Clone
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    GenScript: all cDNA clones in your preferred vector: TCEANC2 (NM_153035)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEANC2
    Primer
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    OriGene qPCR primer pairs and template standards for TCEANC2
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      QuantiTect SYBR Green Assays in human, mouse, rat TCEANC2
      QuantiFast Probe-based Assays in human, mouse, rat TCEANC2

    Additional mRNA sequence: 

    AK027328.1 AK056674.1 AK096488.1 AL049253.1 BC035374.1 

    9 DOTS entries:

    DT.100840671  DT.99953506  DT.40256276  DT.40267098  DT.121431039  DT.40234713  DT.40248675  DT.92051776 
    DT.97857962 

    Selected AceView cDNA sequences (see all 56):

    NM_153035 AK056674 BX097476 BM675385 BM714872 BM768878 BM548881 BQ082987 
    CR592771 BC035374 BE858049 AK096488 AV728976 BP430743 CB047610 AL049253 
    BQ084332 BQ719936 BI909833 CB146767 BM470298 AL578216 BX489416 BU739633 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TCEANC2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:              -           -                                 
    SP2:              -           -     -                           
    SP3:                          -                                 
    SP4:                                                            


    ECgene alternative splicing isoforms for TCEANC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCEANC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGGCTAC
    TCEANC2 Expression
    About this image

    TCEANC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCEANC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558618
        Custom PCR Arrays for TCEANC2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEANC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TCEANC2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tceanc21 , 5 RIKEN cDNA 2210012G02 gene5
    transcription elongation factor A (SII) N-terminal more1
    88.89(n)1
    91.3(a)1
      4 (50.07 cM)5
    665261  NM_025617.21  NP_079893.11 
     1071341555 
    chicken
    (Gallus gallus)
    Aves TCEANC21 transcription elongation factor A (SII) N-terminal more 70.67(n)
    69.23(a)
      424657  NM_001195594.1  NP_001182523.1 
    lizard
    (Anolis carolinensis)
    Reptilia TCEANC26
    transcription elongation factor A (SII) N-terminal...
    72(a)
    1 ↔ 1
    4(105104547-105124086)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.51872 Xenopus laevis transcribed sequence with weak similarity more 73.81(n)    BX855571.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tceanc21 transcription elongation factor A (SII) N-terminal more 63.93(n)
    66.18(a)
      567698  XM_690995.4  XP_696087.1 


    ENSEMBL Gene Tree for TCEANC2 (if available)
    TreeFam Gene Tree for TCEANC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCEANC2 (see all 750)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503857361,2
    --54521199(+) CTCCTC/TAGAGT 1 -- int10--------
    rs798881731,2
    C,F--54521230(+) TGGCCA/GGGATG 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1903210421,2
    --54521281(+) AACCTA/GCACCT 1 -- int10--------
    rs1814736251,2
    --54521389(+) ACTCAA/GTTGGA 1 -- int10--------
    rs1381095431,2
    --54521540(+) TAAAAC/TGTGGA 1 -- int10--------
    rs1869346891,2
    --54521602(+) AGATAA/GTTCTT 1 -- int10--------
    rs67036481,2
    C,F,A,H--54521626(+) tgctgG/Atggtt 1 -- int18Minor allele frequency- A:0.03NS NA CSA WA 914
    rs1888645011,2
    --54521738(+) ATTGAG/TCCCTA 1 -- int10--------
    rs1410609341,2
    --54521901(+) TCTCTC/GCAGGA 1 -- int10--------
    rs1997065941,2
    C--54521968(+) CCATA-/TTCT  
      TTTCTT
    TTCTT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for TCEANC2 (54519260 - 54578192 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TCEANC2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCEANC2
    DNA2.0 Custom Variant and Variant Library Synthesis for TCEANC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCEANC2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TCEANC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 127428 HGNC: 26494 AceView: FLJ32112 Ensembl:ENSG00000116205 euGenes: HUgn127428
    ECgene: TCEANC2 H-InvDB: TCEANC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCEANC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCEANC2 gene:
    Search GeneIP for patents involving TCEANC2

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TCEANC2  
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     Search Tocris compounds for TCEANC2 (TEAN2)
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     Search Addgene for plasmids for TCEANC2
      Search eBioscience for proteins for TCEANC2
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      eBioscience FlowRNA Probe Sets
           
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