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Aliases for TCEANC2 Gene

Aliases for TCEANC2 Gene

  • Transcription Elongation Factor A N-Terminal And Central Domain Containing 2 2 3 5
  • Transcription Elongation Factor A (SII) N-Terminal And Central Domain Containing 2 2 3
  • C1orf83 3 4
  • Transcription Elongation Factor A N-Terminal And Central Domain-Containing Protein 2 3
  • Chromosome 1 Open Reading Frame 83 2

External Ids for TCEANC2 Gene

Previous HGNC Symbols for TCEANC2 Gene

  • C1orf83

Previous GeneCards Identifiers for TCEANC2 Gene

  • GC01P054520

Summaries for TCEANC2 Gene

GeneCards Summary for TCEANC2 Gene

TCEANC2 (Transcription Elongation Factor A N-Terminal And Central Domain Containing 2) is a Protein Coding gene.

Additional gene information for TCEANC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEANC2 Gene

Genomics for TCEANC2 Gene

Regulatory Elements for TCEANC2 Gene

Enhancers for TCEANC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H054093 1 Ensembl ENCODE 46.2 +42.0 42035 3.5 ELF3 FOXA2 FOXA3 CEBPB MAX CEBPG NR2F2 GABPA ZNF121 FOXP2 TCEANC2 LDLRAD1 TMEM59 CDCP2 SSBP3-AS1 MRPL37 ENSG00000279049 GC01P054090
GH01H054081 1.1 Ensembl ENCODE 39.6 +28.2 28177 0.3 TBP FOXA2 RB1 ARID4B SIN3A RAD21 RARA ZNF121 ZNF143 MIXL1 TCEANC2 TMEM59 CDCP2 LDLRAD1 HSPB11 LRRC42 SSBP3-AS1 GC01P054077 LOC100507586
GH01H054051 1.2 ENCODE 29.3 -0.4 -418 3.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MAGOH NDC1 ENSG00000228838 SSBP3-AS1 HSPB11 LRRC42 TCEANC2 PARS2 C1orf123 ENSG00000226938
GH01H054069 0.9 ENCODE 28.1 +16.6 16644 1 ELF3 FOXA2 RB1 ARID4B RAD21 RARA ZNF143 CREM MIXL1 ZNF654 TCEANC2 ENSG00000256407 GC01P054077 MIR4781
GH01H053981 1.2 Ensembl ENCODE 18.2 -71.0 -70963 1.6 ELF3 TBP ARID4B DMAP1 RAD21 RARA YY1 THAP11 SMARCA5 ZBTB11 TCEANC2 LRRC42 HSPB11 LDLRAD1 DIO1 YIPF1 TMEM59 HNRNPA3P12 GC01P054015
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCEANC2 on UCSC Golden Path with GeneCards custom track

Promoters for TCEANC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000006585 -572 2801 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Locations for TCEANC2 Gene

Genomic Locations for TCEANC2 Gene
chr1:54,053,572-54,112,519
(GRCh38/hg38)
Size:
58,948 bases
Orientation:
Plus strand
chr1:54,519,260-54,578,192
(GRCh37/hg19)

Genomic View for TCEANC2 Gene

Genes around TCEANC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEANC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEANC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEANC2 Gene

Proteins for TCEANC2 Gene

  • Protein details for TCEANC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MN5-TEAN2_HUMAN
    Recommended name:
    Transcription elongation factor A N-terminal and central domain-containing protein 2
    Protein Accession:
    Q96MN5
    Secondary Accessions:
    • Q5T702
    • Q8N8N2

    Protein attributes for TCEANC2 Gene

    Size:
    208 amino acids
    Molecular mass:
    24150 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI22668.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TCEANC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEANC2 Gene

Post-translational modifications for TCEANC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEANC2 Gene

No data available for DME Specific Peptides for TCEANC2 Gene

Domains & Families for TCEANC2 Gene

Gene Families for TCEANC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TCEANC2 Gene

Suggested Antigen Peptide Sequences for TCEANC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96MN5

UniProtKB/Swiss-Prot:

TEAN2_HUMAN :
  • Belongs to the TCEANC2 family.
Family:
  • Belongs to the TCEANC2 family.
genes like me logo Genes that share domains with TCEANC2: view

Function for TCEANC2 Gene

Phenotypes From GWAS Catalog for TCEANC2 Gene

Gene Ontology (GO) - Molecular Function for TCEANC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TCEANC2: view
genes like me logo Genes that share phenotypes with TCEANC2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEANC2 Gene

Localization for TCEANC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEANC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEANC2 gene
Compartment Confidence
nucleus 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCEANC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCEANC2: view

Pathways & Interactions for TCEANC2 Gene

SuperPathways for TCEANC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCEANC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCEANC2: view

No data available for Pathways by source and SIGNOR curated interactions for TCEANC2 Gene

Drugs & Compounds for TCEANC2 Gene

No Compound Related Data Available

Transcripts for TCEANC2 Gene

Unigene Clusters for TCEANC2 Gene

Transcription elongation factor A (SII) N-terminal and central domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEANC2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for TCEANC2 Gene

GeneLoc Exon Structure for
TCEANC2
ECgene alternative splicing isoforms for
TCEANC2

Expression for TCEANC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCEANC2 Gene

Protein differential expression in normal tissues from HIPED for TCEANC2 Gene

This gene is overexpressed in Lung (64.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCEANC2 Gene



Protein tissue co-expression partners for TCEANC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCEANC2 Gene:

TCEANC2

SOURCE GeneReport for Unigene cluster for TCEANC2 Gene:

Hs.558618

Evidence on tissue expression from TISSUES for TCEANC2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TCEANC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEANC2 Gene

Orthologs for TCEANC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCEANC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEANC2 33 34
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia TCEANC2 33 34
  • 93.11 (n)
dog
(Canis familiaris)
Mammalia TCEANC2 33 34
  • 92.95 (n)
mouse
(Mus musculus)
Mammalia Tceanc2 33 16 34
  • 88.89 (n)
rat
(Rattus norvegicus)
Mammalia Tceanc2 33
  • 86.47 (n)
oppossum
(Monodelphis domestica)
Mammalia TCEANC2 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCEANC2 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCEANC2 33 34
  • 70.67 (n)
lizard
(Anolis carolinensis)
Reptilia TCEANC2 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17785 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5187 33
zebrafish
(Danio rerio)
Actinopterygii tceanc2 33 34
  • 63.93 (n)
Species where no ortholog for TCEANC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCEANC2 Gene

ENSEMBL:
Gene Tree for TCEANC2 (if available)
TreeFam:
Gene Tree for TCEANC2 (if available)

Paralogs for TCEANC2 Gene

No data available for Paralogs for TCEANC2 Gene

Variants for TCEANC2 Gene

Sequence variations from dbSNP and Humsavar for TCEANC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000014217 -- 54,076,161(+) CCTGT(G/T)TCATG intron-variant
rs1000082212 -- 54,084,021(+) TCGGG(A/T)TTTTT intron-variant
rs1000133245 -- 54,083,737(+) TGACA(C/T)GTTGA intron-variant
rs1000151020 -- 54,075,756(+) CACCT(C/G)TAATC intron-variant
rs1000235823 -- 54,051,805(+) TTACA(C/T)AAATC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TCEANC2 Gene

Variant ID Type Subtype PubMed ID
nsv945957 CNV duplication 23825009
nsv475184 CNV novel sequence insertion 20440878
nsv1011262 CNV gain 25217958

Variation tolerance for TCEANC2 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEANC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEANC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCEANC2 Gene

Disorders for TCEANC2 Gene

Relevant External Links for TCEANC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEANC2

No disorders were found for TCEANC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEANC2 Gene

Publications for TCEANC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp JJ … Guthrie C (Nature structural & molecular biology 2015) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for TCEANC2 Gene

Sources for TCEANC2 Gene

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