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Aliases for TCEANC Gene

Aliases for TCEANC Gene

  • Transcription Elongation Factor A N-Terminal And Central Domain Containing 2 3
  • Transcription Elongation Factor A (SII) N-Terminal And Central Domain Containing 2 5
  • TFIIS Central Domain-Containing Protein 1 4

External Ids for TCEANC Gene

Previous GeneCards Identifiers for TCEANC Gene

  • GC0XP013582
  • GC0XP013584
  • GC0XP011429

Summaries for TCEANC Gene

GeneCards Summary for TCEANC Gene

TCEANC (Transcription Elongation Factor A N-Terminal And Central Domain Containing) is a Protein Coding gene. An important paralog of this gene is TCEA2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEANC Gene

Genomics for TCEANC Gene

Regulatory Elements for TCEANC Gene

Promoters for TCEANC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCEANC on UCSC Golden Path with GeneCards custom track

Genomic Location for TCEANC Gene

Chromosome:
X
Start:
13,652,646 bp from pter
End:
13,681,964 bp from pter
Size:
29,319 bases
Orientation:
Plus strand

Genomic View for TCEANC Gene

Genes around TCEANC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEANC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEANC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEANC Gene

Proteins for TCEANC Gene

  • Protein details for TCEANC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8B7-TEANC_HUMAN
    Recommended name:
    Transcription elongation factor A N-terminal and central domain-containing protein
    Protein Accession:
    Q8N8B7
    Secondary Accessions:
    • A6NI06
    • B2RDM3

    Protein attributes for TCEANC Gene

    Size:
    351 amino acids
    Molecular mass:
    40245 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04930.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TCEANC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEANC Gene

Proteomics data for TCEANC Gene at MOPED

Post-translational modifications for TCEANC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEANC Gene

No data available for DME Specific Peptides for TCEANC Gene

Domains & Families for TCEANC Gene

Protein Domains for TCEANC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEANC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N8B7

UniProtKB/Swiss-Prot:

TEANC_HUMAN :
  • Contains 1 TFIIS central domain.
Domain:
  • Contains 1 TFIIS central domain.
  • Contains 1 TFIIS N-terminal domain.
genes like me logo Genes that share domains with TCEANC: view

No data available for Gene Families for TCEANC Gene

Function for TCEANC Gene

Phenotypes for TCEANC Gene

genes like me logo Genes that share phenotypes with TCEANC: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEANC Gene

Localization for TCEANC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEANC Gene COMPARTMENTS Subcellular localization image for TCEANC gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2
peroxisome 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TCEANC Gene

Pathways & Interactions for TCEANC Gene

SuperPathways for TCEANC Gene

No Data Available

Interacting Proteins for TCEANC Gene

Gene Ontology (GO) - Biological Process for TCEANC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCEANC Gene

Drugs & Compounds for TCEANC Gene

No Compound Related Data Available

Transcripts for TCEANC Gene

Unigene Clusters for TCEANC Gene

Transcription elongation factor A (SII) N-terminal and central domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCEANC Gene

No ASD Table

Relevant External Links for TCEANC Gene

GeneLoc Exon Structure for
TCEANC
ECgene alternative splicing isoforms for
TCEANC

Expression for TCEANC Gene

mRNA expression in normal human tissues for TCEANC Gene

SOURCE GeneReport for Unigene cluster for TCEANC Gene Hs.222855

genes like me logo Genes that share expression patterns with TCEANC: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TCEANC Gene

Orthologs for TCEANC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TCEANC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEANC 35
  • 99.39 (n)
  • 99.21 (a)
TCEANC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 65 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
TCEANC 35
  • 75.58 (n)
  • 68.52 (a)
dog
(Canis familiaris)
Mammalia TCEANC 35
  • 84.3 (n)
  • 79.77 (a)
TCEANC 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tceanc 36
  • 67 (a)
OneToOne
Tceanc 16
Tceanc 35
  • 79.75 (n)
  • 69.91 (a)
rat
(Rattus norvegicus)
Mammalia Tceanc 35
  • 80.27 (n)
  • 70.98 (a)
chicken
(Gallus gallus)
Aves TCEANC 36
  • 52 (a)
OneToOne
TCEANC 35
  • 62.74 (n)
  • 55.17 (a)
lizard
(Anolis carolinensis)
Reptilia TCEANC 36
  • 42 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17490 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12985 35
tceanc 35
  • 58.15 (n)
  • 53.23 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100150588 35
  • 52.99 (n)
  • 44.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8117 36
  • 38 (a)
ManyToMany
TfIIS 36
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T24H10.1 36
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DST1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2769 36
  • 24 (a)
OneToMany
Species with no ortholog for TCEANC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCEANC Gene

ENSEMBL:
Gene Tree for TCEANC (if available)
TreeFam:
Gene Tree for TCEANC (if available)

Paralogs for TCEANC Gene

Paralogs for TCEANC Gene

(3) SIMAP similar genes for TCEANC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TCEANC: view

Variants for TCEANC Gene

Sequence variations from dbSNP and Humsavar for TCEANC Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2361159 - 13,662,996(+) GAGAT(C/T)GAGTG reference, missense
rs2361158 -- 13,650,673(+) TTCAG(C/T)ATAGA upstream-variant-2KB
rs3761626 -- 13,664,596(+) TCTAG(A/G)ATGTT utr-variant-3-prime
rs4143649 -- 13,650,888(+) GAGAT(A/G)GTTGG upstream-variant-2KB
rs4830882 -- 13,656,115(+) TAGCT(A/G)TCCAG intron-variant

Variation tolerance for TCEANC Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEANC Gene

HapMap Linkage Disequilibrium report
TCEANC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEANC Gene

Disorders for TCEANC Gene

Relevant External Links for TCEANC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEANC

No disorders were found for TCEANC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEANC Gene

Publications for TCEANC Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PMID: 23940030) Teixeira F.R. … Gomes M.D. (J. Biol. Chem. 2013) 3

Products for TCEANC Gene

Sources for TCEANC Gene

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