Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TCEAL9 Gene

Aliases for TCEAL9 Gene

  • Transcription Elongation Factor A Like 9 2 3 5
  • Transcription Elongation Factor S-II Protein-Like 9 3 4
  • WW Domain-Binding Protein 5 3 4
  • TCEA-Like Protein 9 3 4
  • Pp21 Homolog 2 3
  • WBP-5 3 4
  • WBP5 3 4
  • Transcription Elongation Factor A Protein-Like 9 3
  • WW Domain Binding Protein 5 2
  • WW Domain Binding Protein 1 3
  • WEX6 3

External Ids for TCEAL9 Gene

Previous HGNC Symbols for TCEAL9 Gene

  • WBP5

Summaries for TCEAL9 Gene

Entrez Gene Summary for TCEAL9 Gene

  • The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein. This gene also encodes a domain with similarity to the transcription elongation factor A, SII-related family. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEAL9 Gene

TCEAL9 (Transcription Elongation Factor A Like 9) is a Protein Coding gene. An important paralog of this gene is TCEAL1.

UniProtKB/Swiss-Prot for TCEAL9 Gene

  • May be involved in transcriptional regulation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL9 Gene

Genomics for TCEAL9 Gene

Regulatory Elements for TCEAL9 Gene

Enhancers for TCEAL9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG103396 1.4 FANTOM5 Ensembl ENCODE 12.5 +41.3 41339 3.5 ATF1 ZNF76 RAD21 ZNF335 ZNF350 FOS EGR2 SP3 ZNF362 CEBPB BEX4 TCEAL9 TCEAL4 LL0XNC01-250H12.3 ENSG00000281091 BEX3
GH0XG103464 0.9 Ensembl ENCODE 13.5 +108.1 108149 1.2 CTCF PKNOX1 ZNF654 REST RAD21 FOXK2 GLIS1 SMC3 ZSCAN29 PRDM10 TCEAL9 BEX3 RAB40A PIR62779 PIR37216
GH0XG103355 0.9 ENCODE 0.7 +0.3 309 2.3 HDAC1 PKNOX1 ATF1 CREB3L1 ZSCAN4 ZNF133 ZNF76 DMAP1 YY1 ZNF366 BEX4 TCEAL9 BEX3
GH0XG103359 0.7 ENCODE 0.7 +3.8 3788 1.0 PKNOX1 TAL1 ETV1 TCF12 GATA2 FOXK2 ZNF600 PRDM10 TRIM24 ZNF548 TCEAL7 MORF4L2-AS1 TCEAL9 BEX3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCEAL9 on UCSC Golden Path with GeneCards custom track

Promoters for TCEAL9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247695 449 2199 PKNOX1 ATF1 CREB3L1 ZSCAN4 ZNF133 ZNF76 KLF17 DMAP1 YY1 ZNF366

Genomic Location for TCEAL9 Gene

103,356,452 bp from pter
103,358,469 bp from pter
2,018 bases
Plus strand

Genomic View for TCEAL9 Gene

Genes around TCEAL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL9 Gene

Proteins for TCEAL9 Gene

  • Protein details for TCEAL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription elongation factor A protein-like 9
    Protein Accession:
    Secondary Accessions:
    • B2R5H6

    Protein attributes for TCEAL9 Gene

    104 amino acids
    Molecular mass:
    12749 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCEAL9 Gene

Post-translational modifications for TCEAL9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEAL9 Gene

No data available for DME Specific Peptides for TCEAL9 Gene

Domains & Families for TCEAL9 Gene

Gene Families for TCEAL9 Gene

Protein Domains for TCEAL9 Gene


Suggested Antigen Peptide Sequences for TCEAL9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TFS-II family. TFA subfamily.
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL9: view

Function for TCEAL9 Gene

Molecular function for TCEAL9 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for TCEAL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050699 WW domain binding IEA --
genes like me logo Genes that share ontologies with TCEAL9: view

Phenotypes for TCEAL9 Gene

MGI mutant phenotypes for TCEAL9:
inferred from 1 alleles
GenomeRNAi human phenotypes for TCEAL9:
genes like me logo Genes that share phenotypes with TCEAL9: view

Animal Models for TCEAL9 Gene

MGI Knock Outs for TCEAL9:

Animal Model Products

CRISPR Products

miRNA for TCEAL9 Gene

miRTarBase miRNAs that target TCEAL9

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCEAL9 Gene

Localization for TCEAL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL9 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEAL9 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TCEAL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCEAL9: view

Pathways & Interactions for TCEAL9 Gene

SuperPathways for TCEAL9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCEAL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCEAL9: view

No data available for Pathways by source and SIGNOR curated interactions for TCEAL9 Gene

Drugs & Compounds for TCEAL9 Gene

No Compound Related Data Available

Transcripts for TCEAL9 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL9 Gene

No ASD Table

Relevant External Links for TCEAL9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCEAL9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TCEAL9 Gene:


Evidence on tissue expression from TISSUES for TCEAL9 Gene

  • Adrenal gland(4.4)
  • Muscle(4.3)
  • Liver(2.2)
  • Pancreas(2.1)
  • Stomach(2.1)
  • Nervous system(2.1)
  • Heart(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with TCEAL9: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEAL9 Gene

Orthologs for TCEAL9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WBP5 34 35
  • 100 (n)
(Bos Taurus)
Mammalia WBP5 34 35
  • 89.87 (n)
(Canis familiaris)
Mammalia WBP5 34 35
  • 89.74 (n)
(Rattus norvegicus)
Mammalia Wbp5 34
  • 87.18 (n)
(Mus musculus)
Mammalia Wbp5 34 35
  • 83.33 (n)
Tceal9 16
Species where no ortholog for TCEAL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL9 Gene

Gene Tree for TCEAL9 (if available)
Gene Tree for TCEAL9 (if available)

Paralogs for TCEAL9 Gene

Paralogs for TCEAL9 Gene Pseudogenes for TCEAL9 Gene

genes like me logo Genes that share paralogs with TCEAL9: view

Variants for TCEAL9 Gene

Sequence variations from dbSNP and Humsavar for TCEAL9 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000540790 -- 103,355,954(+) AAAAA(A/C)AAAAG upstream-variant-2KB
rs1001009911 -- 103,355,511(+) AATTC(G/T)GTATC upstream-variant-2KB
rs1001527220 -- 103,356,505(+) CCTGG(C/T)AATCT utr-variant-5-prime
rs1001558591 -- 103,356,720(+) TCTAC(A/G)GGAAC intron-variant
rs1001910070 -- 103,354,907(+) TGCCT(C/T)TTTTT upstream-variant-2KB

Variation tolerance for TCEAL9 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEAL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL9 Gene

Disorders for TCEAL9 Gene

Relevant External Links for TCEAL9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TCEAL9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL9 Gene

Publications for TCEAL9 Gene

  1. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TCEAL9 Gene

Sources for TCEAL9 Gene

Loading form....