Aliases for TCEAL8 Gene
Aliases for TCEAL8 Gene
External Ids for TCEAL8 Gene
- HGNC: 28683
- Entrez Gene: 90843
- Ensembl: ENSG00000180964
- UniProtKB: Q8IYN2
Previous GeneCards Identifiers for TCEAL8 Gene
- GC0XM102314
- GC0XM102394
- GC0XM102507
- GC0XM092171
Summaries for TCEAL8 Gene
-
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
GeneCards Summary for TCEAL8 Gene
TCEAL8 (Transcription Elongation Factor A Like 8) is a Protein Coding gene. An important paralog of this gene is TCEAL7.
UniProtKB/Swiss-Prot for TCEAL8 Gene
-
May be involved in transcriptional regulation.
Additional gene information for TCEAL8 Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL8 Gene
Genomics for TCEAL8 Gene
GeneHancer (GH) Regulatory Elements for TCEAL8 Gene
Regulatory Element Products
Genomic Locations for TCEAL8 Gene
- chrX:103,252,995-103,255,203
- (GRCh38/hg38)
- Size:
- 2,209 bases
- Orientation:
- Minus strand
- chrX:102,507,923-102,510,131
- (GRCh37/hg19)
Genomic View for TCEAL8 Gene
- Cytogenetic band:
-
- Xq22.1 by Ensembl
- Xq22.1 by Entrez Gene
- Xq22.1 by HGNC


RefSeq DNA sequence for TCEAL8 Gene
Proteins for TCEAL8 Gene
-
Protein details for TCEAL8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IYN2-TCAL8_HUMAN
- Recommended name:
- Transcription elongation factor A protein-like 8
- Protein Accession:
- Q8IYN2
Protein attributes for TCEAL8 Gene
- Size:
- 117 amino acids
- Molecular mass:
- 13616 Da
- Quaternary structure:
- No Data Available
Protein Expression for TCEAL8 Gene
Post-translational modifications for TCEAL8 Gene
- Ubiquitination at isoforms=62
Other Protein References for TCEAL8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TCEAL8
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Protein Products
-
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- antibodies-online: Search results for 6 available TCEAL8 Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for TCEAL8
Assay Products
No data available for DME Specific Peptides for TCEAL8 Gene
Domains & Families for TCEAL8 Gene
Gene Families for TCEAL8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TCEAL8 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TCEAL8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IYN2- Family:
-
- Belongs to the TFS-II family. TFA subfamily.
Function for TCEAL8 Gene
Molecular function for TCEAL8 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0050699 | WW domain binding | IBA | -- |
Phenotypes for TCEAL8 Gene
- GenomeRNAi human phenotypes for TCEAL8:
Animal Model Products
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-
-
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-
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-
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- Overview of 141 available TCEAL8 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for TCEAL8 Gene
- miRTarBase miRNAs that target TCEAL8
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TCEAL8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TCEAL8
-
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-
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-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEAL8 Gene
Localization for TCEAL8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TCEAL8 Gene
- Nucleus.
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | -- |
Pathways & Interactions for TCEAL8 Gene
Interacting Proteins for TCEAL8 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for TCEAL8 Gene
Transcripts for TCEAL8 Gene
mRNA/cDNA for TCEAL8 Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (260) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TCEAL8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TCEAL8
- genomics-online: gRNA clones - Search results for 141 available TCEAL8 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TCEAL8
- GenScript: Design CRISPR guide RNA sequences for TCEAL8
miRNA Products
- Search ViGene Biosciences for TCEAL8
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TCEAL8
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- genomics-online: shRNA clones - Search results for 141 available TCEAL8 gene related products
- Overview of 141 available TCEAL8 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TCEAL8 gene
Clone Products
- Sino Biological Human cDNA Clone for TCEAL8
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- VectorBuilder custom plasmid, inducible vectors for TCEAL8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TCEAL8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TCEAL8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||
SP2: | |||||||||||||||
SP3: | - | - |
Expression for TCEAL8 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCEAL8 Gene
NURSA nuclear receptor signaling pathways regulating expression of TCEAL8 Gene:
TCEAL8SOURCE GeneReport for Unigene cluster for TCEAL8 Gene:
Hs.389734Evidence on tissue expression from TISSUES for TCEAL8 Gene
- Liver(4.3)
- Nervous system(3.5)
Primer Products
-
OriGene qPCR primer pairs for TCEAL8
-
OriGene qPCR primer pairs and template standards for TCEAL8
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEAL8 Gene
Orthologs for TCEAL8 Gene
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TCEAL8 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | TCEAL8 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
TCEAL8 33 |
|
||||
-- 34 |
|
OneToMany | |||
rat (Rattus norvegicus) |
Mammalia | Tceal8 33 |
|
||
mouse (Mus musculus) |
Mammalia | Tceal8 33 16 34 |
|
- Species where no ortholog for TCEAL8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TCEAL8 Gene
(3) SIMAP similar genes for TCEAL8 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for TCEAL8 Gene
Variants for TCEAL8 Gene
SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1004376515 | -- | 103,253,967(-) | A/C | coding_sequence_variant, missense_variant | |
rs1006805737 | -- | 103,253,577(-) | T/A/G | 3_prime_UTR_variant | |
rs1007443776 | -- | 103,254,380(-) | C/G | intron_variant | |
rs1008484324 | -- | 103,256,631(-) | GAGAGAGAG/GAGAG | upstream_transcript_variant | |
rs1008944785 | -- | 103,256,597(-) | C/A | upstream_transcript_variant |
Additional Variant Information for TCEAL8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TCEAL8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL8 Gene
Disorders for TCEAL8 Gene
Additional Disease Information for TCEAL8
No disorders were found for TCEAL8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL8 Gene
Publications for TCEAL8 Gene
- Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter EE … Ponting CP (BMC evolutionary biology 2005) 2 3 58
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58
- Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
Products for TCEAL8 Gene
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- Invitrogen Antibodies for TCEAL8
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- VectorBuilder custom plasmid, inducible vectors for TCEAL8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TCEAL8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 13 available TCEAL8 Antibodies ranked by validation data
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- antibodies-online: Search results for available TCEAL8 related products ranked by validation data
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- Overview of 141 available TCEAL8 gene related products
Sources for TCEAL8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
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- (145) dbSUPER
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- (147) Gene ORGANizer
- (148) abm
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- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew