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TCEAL8 Gene(Protein Coding)

Transcription Elongation Factor A Like 8

GCID:
GC0XM103252
GIFtS:
47
Genes Participants
UDN Logo

Aliases for TCEAL8 Gene

Aliases for TCEAL8 Gene

  • Transcription Elongation Factor A Like 8 2 3
  • Transcription Elongation Factor A (SII)-Like 8 2 3 5
  • Transcription Elongation Factor S-II Protein-Like 8 3 4
  • TCEA-Like Protein 8 3 4
  • WEX3 3

External Ids for TCEAL8 Gene

Previous GeneCards Identifiers for TCEAL8 Gene

  • GC0XM102314
  • GC0XM102394
  • GC0XM102507
  • GC0XM092171

Summaries for TCEAL8 Gene

Entrez Gene Summary for TCEAL8 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEAL8 Gene

TCEAL8 (Transcription Elongation Factor A Like 8) is a Protein Coding gene. An important paralog of this gene is TCEAL7.

UniProtKB/Swiss-Prot for TCEAL8 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL8 Gene

Genomics for TCEAL8 Gene

Products:

  1. Regulatory Element

Regulatory Elements for TCEAL8 Gene

Enhancers for TCEAL8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TCEAL8 on UCSC Golden Path with GeneCards custom track

Promoters for TCEAL8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCEAL8 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TCEAL8 gene promoter:

Genomic Location for TCEAL8 Gene

Chromosome:
X
Start:
103,252,995 bp from pter
End:
103,255,203 bp from pter
Size:
2,209 bases
Orientation:
Minus strand

Genomic View for TCEAL8 Gene

Genes around TCEAL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TCEAL8 Gene

Proteins for TCEAL8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TCEAL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYN2-TCAL8_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 8
    Protein Accession:
    Q8IYN2

    Protein attributes for TCEAL8 Gene

    Size:
    117 amino acids
    Molecular mass:
    13616 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCEAL8 Gene

Proteomics data for TCEAL8 Gene at MOPED

Protein Expression for TCEAL8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TCEAL8 Gene

  • Ubiquitination at Lys 62
  • Modification sites at PhosphoSitePlus

Other Protein References for TCEAL8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCEAL8 Gene

Domains & Families for TCEAL8 Gene

Gene Families for TCEAL8 Gene

HGNC:

Protein Domains for TCEAL8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYN2

UniProtKB/Swiss-Prot:

TCAL8_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL8: view

Function for TCEAL8 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for TCEAL8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for TCEAL8 Gene

GenomeRNAi human phenotypes for TCEAL8:
genes like me logo Genes that share phenotypes with TCEAL8: view

Animal Model Products

miRNA for TCEAL8 Gene

miRTarBase miRNAs that target TCEAL8

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEAL8 Gene

Localization for TCEAL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL8 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEAL8 Gene COMPARTMENTS Subcellular localization image for TCEAL8 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for TCEAL8 Gene

Pathways & Interactions for TCEAL8 Gene

SuperPathways for TCEAL8 Gene

PathCards logoMore details on SuperPathways for TCEAL8
No Data Available

Interacting Proteins for TCEAL8 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000353093%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000339007%0d%0a
Selected Interacting proteins: ENSP00000353093 Q8IYN2-TCAL8_HUMAN for TCEAL8 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TCEAL8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCEAL8 Gene

Drugs & Compounds for TCEAL8 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TCEAL8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for TCEAL8 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(260) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCEAL8 Gene

Transcription elongation factor A (SII)-like 8:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1:
SP2:
SP3: - -

Relevant External Links for TCEAL8 Gene

GeneLoc Exon Structure for
TCEAL8
ECgene alternative splicing isoforms for
TCEAL8

Expression for TCEAL8 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for TCEAL8 Gene

mRNA expression in normal human tissues for TCEAL8 Gene
mRNA expression by GTEx for TCEAL8 Gene

Protein differential expression in normal tissues from HIPED for TCEAL8 Gene

This gene is overexpressed in NK cells (40.7), Fetal gut (20.8), and Platelet (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCEAL8 Gene



SOURCE GeneReport for Unigene cluster for TCEAL8 Gene Hs.389734

genes like me logo Genes that share expression patterns with TCEAL8: view

Protein tissue co-expression partners for TCEAL8 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TCEAL8 Gene

Orthologs for TCEAL8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia TCEAL8 35
  • 93.45 (n)
  • 92.31 (a)
TCEAL8 36
  • 92 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia TCEAL8 35
  • 92.88 (n)
  • 93.16 (a)
-- 36
  • 81 (a)
 OneToMany
-- 36
  • 93 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Tceal8 35
  • 79.49 (n)
  • 72.65 (a)
Tceal8 16
Tceal8 36
  • 73 (a)
 ManyToMany
chimpanzee
(Pan troglodytes)
 Mammalia TCEAL8 35
  • 99.72 (n)
  • 100 (a)
TCEAL8 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Tceal8 35
  • 80.34 (n)
  • 72.65 (a)
Species with no ortholog for TCEAL8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL8 Gene

ENSEMBL:
Gene Tree for TCEAL8 (if available)
TreeFam:
Gene Tree for TCEAL8 (if available)

Paralogs for TCEAL8 Gene

Paralogs for TCEAL8 Gene

(3) SIMAP similar genes for TCEAL8 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TCEAL8 Gene

genes like me logo Genes that share paralogs with TCEAL8: view

Variants for TCEAL8 Gene

Sequence variations from dbSNP and Humsavar for TCEAL8 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747736694 -- 103,253,642(+) AGCAC(A/T)CAGGA reference, missense
rs747842883 -- 103,253,845(+) TCTGC(A/T)TCCTG reference, missense
rs747851150 -- 103,252,815(+) AGTAC(A/G)AGTTG downstream-variant-500B
rs748256728 -- 103,257,061(+) TGGAC(A/T)TCCAT upstream-variant-2KB
rs748348168 -- 103,255,022(+) TTTCT(A/G)CTCTC intron-variant

Variation tolerance for TCEAL8 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TCEAL8 Gene

Disorders for TCEAL8 Gene

Relevant External Links for TCEAL8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEAL8

No disorders were found for TCEAL8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL8 Gene

Publications for TCEAL8 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for TCEAL8 Gene

Sources for TCEAL8 Gene

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