Aliases for TCEAL8 Gene
Aliases for TCEAL8 Gene
External Ids for TCEAL8 Gene
- HGNC: 28683
- Entrez Gene: 90843
- Ensembl: ENSG00000180964
- UniProtKB: Q8IYN2
Previous GeneCards Identifiers for TCEAL8 Gene
- GC0XM102314
- GC0XM102394
- GC0XM102507
- GC0XM092171
Summaries for TCEAL8 Gene
-
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
GeneCards Summary for TCEAL8 Gene
TCEAL8 (Transcription Elongation Factor A Like 8) is a Protein Coding gene. An important paralog of this gene is TCEAL7.
UniProtKB/Swiss-Prot for TCEAL8 Gene
-
May be involved in transcriptional regulation.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL8 Gene
Genomics for TCEAL8 Gene
Regulatory Elements for TCEAL8 Gene
Enhancers for TCEAL8 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH0XG103214 | 1 | ENCODE | 12.7 | +39.4 | 39442 | 2.6 | HDGF ATF1 CREB3L1 YY1 GLIS2 KLF13 SP3 YY2 REST KAT8 | BEX4 TCEAL8 LOC100420653 BEX1 BEX2 GC0XM103234 |
| GH0XG103441 | 0.9 | Ensembl ENCODE | 11.1 | -187.2 | -187199 | 1.7 | CTCF JUN ZNF316 MAFF ZNF547 FOS MAFK EMSY | BEX4 BEX3 ENSG00000234405 LOC100420653 TCEAL8 PIR37216 PIR62779 |
| GH0XG103438 | 0.6 | ENCODE | 11.1 | -185.0 | -185002 | 2.6 | TAL1 TCF12 ARID1B GATA3 ZNF316 MAFF NCOR1 IKZF1 MAFK EMSY | BEX4 BEX3 ENSG00000234405 LOC100420653 TCEAL8 PIR37216 PIR62779 |
| GH0XG103740 | 0.5 | ENCODE | 5.3 | -486.7 | -486731 | 2.7 | POLR2A POU5F1 CHD7 | TMEM31 PLP1 TCEAL8 TCEAL3 GLRA4 |
| GH0XG103253 | 1 | ENCODE | 0.7 | +0.5 | 494 | 2.8 | PKNOX1 ATF1 CREB3L1 FEZF1 ZNF48 ETS1 TCF12 SP3 SP5 TSHZ1 | BEX1 TCEAL8 GC0XM103234 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TCEAL8 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TCEAL8 gene promoter:
Regulatory Element Products
Genomic Location for TCEAL8 Gene
- Chromosome:
- X
- Start:
- 103,252,995 bp from pter
- End:
- 103,255,203 bp from pter
- Size:
- 2,209 bases
- Orientation:
- Minus strand
Genomic View for TCEAL8 Gene
Genes around TCEAL8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq22.1 by Ensembl
- Xq22.1 by Entrez Gene
- Xq22.1 by HGNC
TCEAL8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TCEAL8 Gene
Proteins for TCEAL8 Gene
-
Protein details for TCEAL8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IYN2-TCAL8_HUMAN
- Recommended name:
- Transcription elongation factor A protein-like 8
- Protein Accession:
- Q8IYN2
Protein attributes for TCEAL8 Gene
- Size:
- 117 amino acids
- Molecular mass:
- 13616 Da
- Quaternary structure:
- No Data Available
Protein Expression for TCEAL8 Gene
Post-translational modifications for TCEAL8 Gene
Other Protein References for TCEAL8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TCEAL8
- Novus Biologicals Antibodies for TCEAL8
- Invitrogen Antibodies for TCEAL8
- antibodies-online Antibodies for TCEAL8: See all 7
- Search GeneTex for Antibodies for TCEAL8
Protein Products
-
OriGene Purified Proteins for TCEAL8
- Search Origene for MassSpec and Protein Over-expression Lysates for TCEAL8
- Origene Custom Protein Services for TCEAL8
- Novus Biologicals proteins for TCEAL8
- antibodies-online Proteins for TCEAL8: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for TCEAL8
No data available for DME Specific Peptides for TCEAL8 Gene
Domains & Families for TCEAL8 Gene
Gene Families for TCEAL8 Gene
Protein Domains for TCEAL8 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TCEAL8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IYN2- Family:
-
- Belongs to the TFS-II family. TFA subfamily.
Function for TCEAL8 Gene
Molecular function for TCEAL8 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
Phenotypes for TCEAL8 Gene
- GenomeRNAi human phenotypes for TCEAL8:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for TCEAL8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TCEAL8 gene
- Search ViGene Biosciences for TCEAL8
CRISPR Products
-
OriGene CRISPR knockouts for TCEAL8
-
Santa Cruz Biotechnology (SCBT) CRISPR for TCEAL8
- GenScript: Design CRISPR guide RNA sequences for TCEAL8
miRNA for TCEAL8 Gene
- miRTarBase miRNAs that target TCEAL8
miRNA Products
- Search ViGene Biosciences for TCEAL8
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for TCEAL8
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-
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Clone Products
- Sino Biological Human cDNA Clone for TCEAL8
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- VectorBuilder custom plasmid, inducible vectors for TCEAL8
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for TCEAL8
-
ViGene Biosciences adenoviral particle packaged cDNA for TCEAL8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TCEAL8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TCEAL8 gene
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEAL8 Gene
Localization for TCEAL8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TCEAL8 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for TCEAL8 Gene
No Data Available
Interacting Proteins for TCEAL8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for TCEAL8 Gene
Transcripts for TCEAL8 Gene
mRNA/cDNA for TCEAL8 Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (260) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TCEAL8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TCEAL8
-
Santa Cruz Biotechnology (SCBT) CRISPR for TCEAL8
- GenScript: Design CRISPR guide RNA sequences for TCEAL8
miRNA Products
- Search ViGene Biosciences for TCEAL8
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for TCEAL8
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-
ViGene Biosciences ready-to-package AAV shRNAs for TCEAL8 gene
Clone Products
- Sino Biological Human cDNA Clone for TCEAL8
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TCEAL8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TCEAL8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||
| SP2: | |||||||||||||||
| SP3: | - | - |
Expression for TCEAL8 Gene
This gene is overexpressed in NK cells (40.7), Fetal gut (20.8), and Platelet (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCEAL8 Gene
NURSA nuclear receptor signaling pathways regulating expression of TCEAL8 Gene:
TCEAL8SOURCE GeneReport for Unigene cluster for TCEAL8 Gene:
Hs.389734Evidence on tissue expression from TISSUES for TCEAL8 Gene
- Liver(4.3)
- Nervous system(3.5)
Primer Products
-
OriGene qPCR primer pairs and template standards for TCEAL8
-
OriGene qPCR primer pairs for TCEAL8
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEAL8 Gene
Orthologs for TCEAL8 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TCEAL8 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | TCEAL8 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| TCEAL8 34 |
|
||||
| -- 35 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Tceal8 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tceal8 34 16 35 |
|
- Species where no ortholog for TCEAL8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TCEAL8 Gene
(3) SIMAP similar genes for TCEAL8 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for TCEAL8 Gene
Variants for TCEAL8 Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1004376515 | -- | 103,253,967(+) | TTCAC(A/C)AGACT | reference, missense | |
| rs1006805737 | -- | 103,253,577(+) | AATGC(G/T)AACAG | utr-variant-3-prime | |
| rs1007443776 | -- | 103,254,380(+) | AGCCT(C/G)TCACC | intron-variant | |
| rs1008484324 | -- | 103,256,631(+) | TGTTT(-/GAGA)GAGAG | upstream-variant-2KB | |
| rs1008944785 | -- | 103,256,597(+) | AATTT(A/C)TTCCA | upstream-variant-2KB |
Residual Variation Intolerance Score:
47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.12;
2.78% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TCEAL8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TCEAL8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL8 Gene
Disorders for TCEAL8 Gene
Relevant External Links for TCEAL8
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- TCEAL8
No disorders were found for TCEAL8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL8 Gene
Publications for TCEAL8 Gene
- Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3 64
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
- Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
Products for TCEAL8 Gene
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- Custom Antibody ServicesOriGene Antibodies for TCEAL8
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- ViGene Biosciences adenoviral particle packaged cDNA for TCEAL8 gene
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- Horizon Cell Lines for TCEAL8
- Cyagen custom Knockout/knockin (KOKI) mouse models for TCEAL8
- VectorBuilder custom plasmid, inducible vectors for TCEAL8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TCEAL8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TCEAL8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (18) KEGG
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- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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- (100) COMPARTMENTS
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- (104) Addgene
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- (154) TISSUES
- (155) Gene ORGANizer