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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCEAL8 Gene

protein-coding   GIFtS: 44
GCID: GC0XM102507

Transcription Elongation Factor A (SII)-Like 8

  Search for TCEAL8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcription Elongation Factor A (SII)-Like 81 2
Transcription Elongation Factor S-II Protein-Like 82 3
TCEA-Like Protein 82 3
Transcription Elongation Factor A Protein-Like 82

External Ids:    HGNC: 286831   Entrez Gene: 908432   Ensembl: ENSG000001809647   UniProtKB: Q8IYN23   

Export aliases for TCEAL8 gene to outside databases

Previous GC identifers: GC0XM102314 GC0XM102394 GC0XM092171


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCEAL8 Gene:
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of
this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a
promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing
results in multiple transcript variants encoding a single isoform. (provided by RefSeq, Jul 2008)

GeneCards Summary for TCEAL8 Gene: 
TCEAL8 (transcription elongation factor A (SII)-like 8) is a protein-coding gene. An important paralog of this gene is TCEAL7.

UniProtKB/Swiss-Prot: TCAL8_HUMAN, Q8IYN2
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCEAL8 gene promoter:
         p53   AML1a   FOXO3   FOXO3b   MZF-1   N-Myc   POU2F1   FOXJ2 (long isoform)   FOXO3a   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCEAL8 promoter sequence
   Search SABiosciences Chromatin IP Primers for TCEAL8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEAL8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.1

TCEAL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEAL8 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM102507:  view genomic region     (about GC identifiers)

Start:
102,507,923 bp from pter      End:
102,510,131 bp from pter
Size:
2,209 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCAL8_HUMAN, Q8IYN2 (See protein sequence)
Recommended Name: Transcription elongation factor A protein-like 8  
Size: 117 amino acids; 13616 Da
Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for TCEAL8: NX_Q8IYN2

Explore proteomics data for TCEAL8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IYN2

  • TCEAL8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCEAL8 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001006685.1  NP_699164.1  

    ENSEMBL proteins: 
     ENSP00000353093   ENSP00000361770   ENSP00000390880  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TCEAL8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR021156 TF_A-like/BEX-like
     IPR010370 TFA

    Graphical View of Domain Structure for InterPro Entry Q8IYN2

    ProtoNet protein and cluster: Q8IYN2

    UniProtKB/Swiss-Prot: TCAL8_HUMAN, Q8IYN2
    Similarity: Belongs to the TFS-II family. TFA subfamily


    TCEAL8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCAL8_HUMAN, Q8IYN2
    Function: May be involved in transcriptional regulation

    Animal Models:

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCEAL8

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TCEAL8 (Q8IYN23 ENSP000003530934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    TCEAL8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCEAL8 (TCAL8)

    Search CenterWatch for drugs/clinical trials and news about TCEAL8 / TCAL8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCEAL8 gene (2 alternative transcripts): 
    NM_001006684.1  NM_153333.2  

    Unigene Cluster for TCEAL8:

    Transcription elongation factor A (SII)-like 8
    Hs.389734  [show with all ESTs]
    Unigene Representative Sequence: BF673962
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360000 ENST00000372685(uc004ejx.3 uc004ejy.3) ENST00000451678

    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate TCEAL8 (see all 25):
    hsa-miR-4317 hsa-miR-548j hsa-miR-4307 hsa-miR-548i hsa-miR-520a-5p hsa-miR-649 hsa-miR-320e hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidTCEAL8 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEAL8

    Additional mRNA sequence: 

    AK026349.1 AL833632.1 BC035573.1 

    8 DOTS entries:

    DT.418030  DT.91689144  DT.100803085  DT.91749246  DT.91749238  DT.121305812  DT.91749237  DT.95300929 

    24/260 AceView cDNA sequences (see all 260):

    CD108147 CF130482 CR622012 CA313232 AK026349 AI078020 BU622807 AI342578 
    AI471010 CA312202 BU165732 AA970699 BM310152 AA442680 BM717832 CA413791 
    AW583269 BU785705 AI092708 CA310769 AI129630 BQ007597 CB051670 BQ071743 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL8    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
    SP1:                                                
    SP2:                                                
    SP3:              -     -                           


    ECgene alternative splicing isoforms for TCEAL8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCEAL8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTAAAGTA
    TCEAL8 Expression
    About this image


    See TCEAL8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCEAL8

    SOURCE GeneReport for Unigene cluster: Hs.389734
        SABiosciences Custom PCR Arrays for TCEAL8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for TCEAL8 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tceal81 , 5 transcription elongation factor A (SII)-like 81, 5 79.49(n)1
    72.65(a)1
      X (57.40 cM)5
    666841  NM_001168578.11  NP_001162050.11 
     1361700815 


    ENSEMBL Gene Tree for TCEAL8 (if available)
    TreeFam Gene Tree for TCEAL8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCEAL8 gene
    TCEAL72  
    3 SIMAP similar genes for TCEAL8 using alignment to 2 protein entries:     TCAL8_HUMAN (see all proteins):
    TCEAL5    TCEAL1    TCEAL6

    TCEAL8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TCEAL8
    PGOHUM00000237643


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/39 SNPs in TCEAL8 are shown (see all 39)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1822124691,2
    --102476947(+) GAAGTA/CCCACC 2 -- ds50010--------
    rs1859059181,2
    --102476948(+) AAGTCC/TCACCT 2 -- ds50010--------
    rs38871161,2
    C,F,H--102477037(+) CGGTGG/AGGTTT 2 -- ds50018Minor allele frequency- A:0.03NS EA NA 1090
    rs1904638691,2
    --102477141(+) AGGAAC/TCAGGG 2 -- ds50010--------
    rs1826976401,2
    C--102477257(+) TATTGA/GTGCTT 2 -- ds50010--------
    rs1420580851,2
    C--102477305(+) CAAGAG/TCTCAC 2 -- ds50010--------
    rs1853792511,2
    --102477710(+) TACACA/TCACGC 2 -- ut310--------
    rs1911581261,2
    C--102477724(+) CACACA/GAAGTT 2 -- ut310--------
    rs1511499581,2
    --102477946(+) GATTAA/CAAGTA 2 -- ut310--------
    rs45968151,2
    C,H--102478019(+) TATTAG/TGCAAA 2 -- ut31 ese35Minor allele frequency- T:0.00NS EA NA 420

    HapMap Linkage Disequilibrium report for TCEAL8 (102507923 - 102510131 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TCEAL8: --

    Locus Specific Mutation Databases (LSDB): TCEAL8
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TCEAL8
    DNA2.0 Custom Variant and Variant Library Synthesis for TCEAL8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCEAL8 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TCEAL8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    7. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)1 Wang J....He F. (2008)
    8. Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR. (PubMed id 10051408)1 Pillutla R.C.... Shatkin A.J. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90843 HGNC: 28683 AceView: TCEAL8 Ensembl:ENSG00000180964 euGenes: HUgn90843
    ECgene: TCEAL8 H-InvDB: TCEAL8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCEAL8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCEAL8 gene:
    Search GeneIP for patents involving TCEAL8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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