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TCEAL8 Gene

protein-coding GIFtS: 45
GCID: GC0XM102507

Transcription Elongation Factor A (SII)-Like 8

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MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Transcription Elongation Factor A (SII)-Like 8¹ ²
Transcription Elongation Factor S-II Protein-Like 8² ³
TCEA-Like Protein 8² ³
WEX3²
Transcription Elongation Factor A Protein-Like 8²

External Ids:	HGNC: 28683¹	Entrez Gene: 90843²	Ensembl: ENSG00000180964⁷	UniProtKB: Q8IYN2³

Export aliases for TCEAL8 gene to outside databases

Previous GC identifers: GC0XM102314 GC0XM102394 GC0XM092171

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCEAL8 Gene:

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of

this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a

promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing

results in multiple transcript variants encoding a single isoform. (provided by RefSeq, Jul 2008)

GeneCards Summary for TCEAL8 Gene:

TCEAL8 (transcription elongation factor A (SII)-like 8) is a protein-coding gene. An important paralog of this gene is TCEAL7.

UniProtKB/Swiss-Prot: TCAL8_HUMAN, Q8IYN2

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000023.10 NC_018934.2 NT_011651.18

Regulatory elements:

Regulatory transcription factor binding sites in the TCEAL8 gene promoter:
p53 AML1a FOXO3 FOXO3b MZF-1 N-Myc POU2F1 FOXJ2 (long isoform) FOXO3a FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TCEAL8 promoter sequence

Search Chromatin IP Primers for TCEAL8

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCEAL8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22.1

TCEAL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEAL8 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM102507: view genomic region (about GC identifiers)

Start:	102,507,923 bp from pter	End:	102,510,131 bp from pter
Size:	2,209 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
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About This Section

UniProtKB/Swiss-Prot: TCAL8_HUMAN, Q8IYN2 (See protein sequence)

Recommended Name: Transcription elongation factor A protein-like 8

Size: 117 amino acids; 13616 Da

Explore the universe of human proteins at neXtProt for TCEAL8: NX_Q8IYN2

Explore proteomics data for TCEAL8 at MOPED

Post-translational modifications:

Ubiquitination² at Lys62

Modification sites at PhosphoSitePlus

See TCEAL8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001006685.1 NP_699164.1

ENSEMBL proteins:

ENSP00000353093 ENSP00000361770 ENSP00000390880

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

2 InterPro protein domains:

IPR021156 TF_A-like/BEX-like

IPR010370 TFA

Graphical View of Domain Structure for InterPro Entry Q8IYN2

ProtoNet protein and cluster: Q8IYN2

UniProtKB/Swiss-Prot: TCAL8_HUMAN, Q8IYN2

Similarity: Belongs to the TFS-II family. TFA subfamily

Find genes that share domains with TCEAL8 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TCAL8_HUMAN, Q8IYN2

Function: May be involved in transcriptional regulation

Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

TCAL8_HUMAN, Q8IYN2: Nucleus (Probable)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	4
cytosol	2
extracellular	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

Find genes that share ontologies with TCEAL8 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for TCEAL8
Interactions:

Search GeneGlobe Interaction Network for TCEAL8

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for TCEAL8 (Q8IYN2³ ENSP00000353093⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993³, ENSP00000339007⁴	I2D: score=2 STRING: ENSP00000339007
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-templated	IEA	--
GO:0006355	regulation of transcription, DNA-templated	IEA	--

Find genes that share ontologies with TCEAL8 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for TCEAL8 gene (2 alternative transcripts):

NM_001006684.1 NM_153333.2

Unigene Cluster for TCEAL8:

Transcription elongation factor A (SII)-like 8

Hs.389734 [show with all ESTs]

Unigene Representative Sequence: BF673962

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000360000 ENST00000372685(uc004ejx.3 uc004ejy.3) ENST00000451678

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Additional mRNA sequence:

AK026349.1 AL833632.1 BC035573.1

8 DOTS entries:

DT.418030 DT.91689144 DT.100803085 DT.91749246 DT.91749238 DT.121305812 DT.91749237 DT.95300929

Selected AceView cDNA sequences (see all 260):

BM717832 CA413791 AW583269 BU785705 AI092708 CA310769 AI129630 BQ007597

CB051670 BQ071743 AI028462 CA411971 BM310985 AA778937 AA774643 CB147964

BM693509 AA507576 AA700191 BM981717 BF725944 CA424198 AA907692 AI380330

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL8 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	·	4c
SP1:
SP2:
SP3:					-		-

ECgene alternative splicing isoforms for TCEAL8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TCEAL8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTGTAAAGTA

About this image

TCEAL8 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TCEAL8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.389734

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TCEAL8 gene from Selected species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tceal8^{1 , 5}	transcription elongation factor A (SII)-like 8^{1, 5}	79.49(n)¹ 72.65(a)¹		X (57.40 cM)⁵ 66684¹ NM_025703.3¹ NP_079979.2¹ 136170081⁵

ENSEMBL Gene Tree for TCEAL8 (if available)
TreeFam Gene Tree for TCEAL8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for TCEAL8 gene

TCEAL7²

3 SIMAP similar genes for TCEAL8 using alignment to 2 protein entries: TCAL8_HUMAN (see all proteins):

TCEAL5 TCEAL1 TCEAL6

Find genes that share paralogs with TCEAL8 About GenesLikeMe

1 Pseudogenes.org Pseudogene for TCEAL8
PGOHUM00000237643

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182212469^1,2		--	102476947(+)	`GAAGTA/CCCACC`	2	--	ds500¹		0	--	--	--	--
rs185905918^1,2		--	102476948(+)	`AAGTCC/TCACCT`	2	--	ds500¹		0	--	--	--	--
rs3887116^1,2	C,F,H	--	102477037(+)	`CGGTGG/AGGTTT`	2	--	ds500¹		8		NS EA NA	1090
rs190463869^1,2		--	102477141(+)	`AGGAAC/TCAGGG`	2	--	ds500¹		0	--	--	--	--
rs182697640^1,2	C	--	102477257(+)	`TATTGA/GTGCTT`	2	--	ds500¹		0	--	--	--	--
rs142058085^1,2	C	--	102477305(+)	`CAAGAG/TCTCAC`	2	--	ds500¹		0	--	--	--	--
rs185379251^1,2		--	102477710(+)	`TACACA/TCACGC`	2	--	ut3¹		0	--	--	--	--
rs191158126^1,2	C	--	102477724(+)	`CACACA/GAAGTT`	2	--	ut3¹		0	--	--	--	--
rs151149958^1,2		--	102477946(+)	`GATTAA/CAAGTA`	2	--	ut3¹		0	--	--	--	--
rs4596815^1,2	C,H	--	102478019(+)	`TATTAG/TGCAAA`	2	--	ut3¹ ese³		5		NS EA NA	420

HapMap Linkage Disequilibrium report for TCEAL8 (102507923 - 102510131 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for TCEAL8: --
Locus Specific Mutation Databases (LSDB): TCEAL8

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TCEAL8 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TCEAL8)

The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (Nature 2005)
Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PubMed id 16221301)^{1, 3} Winter E.E. and Ponting C.P. (BMC Evol. Biol. 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (EMBO J. 2009)
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)¹ Wang J....He F. (J. Proteome Res. 2008)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR. (PubMed id 10051408)¹ Pillutla R.C.... Shatkin A.J. (Genomics 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 90843	HGNC: 28683	AceView: TCEAL8	Ensembl:ENSG00000180964	euGenes: HUgn90843
ECgene: TCEAL8	H-InvDB: TCEAL8

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TCEAL8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TCEAL8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TCEAL8 gene:
Search GeneIP for patents involving TCEAL8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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TCEAL8 Gene

Transcription Elongation Factor A (SII)-Like 8

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TCEAL8 Gene

Transcription Elongation Factor A (SII)-Like 8

Aliasesfor TCEAL8 gene

Summariesfor TCEAL8 gene

Genomic Viewsfor TCEAL8 gene

Proteinsfor TCEAL8 gene

TCEAL8 Human Recombinant Protein Products:

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Domains /Familiesfor TCEAL8 gene

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Expression for TCEAL8 gene

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Disorders / Diseasesfor TCEAL8 gene

Publicationsfor TCEAL8 gene

External Searches for TCEAL8 gene

Genome Databases showing TCEAL8 gene

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for TCEAL8 gene

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for TCEAL8 gene

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for TCEAL8 gene

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