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Aliases for TCEAL8 Gene

Aliases for TCEAL8 Gene

  • Transcription Elongation Factor A (SII)-Like 8 2 3
  • Transcription Elongation Factor S-II Protein-Like 8 3 4
  • TCEA-Like Protein 8 3 4
  • Transcription Elongation Factor A Protein-Like 8 3
  • WEX3 3

External Ids for TCEAL8 Gene

Summaries for TCEAL8 Gene

Entrez Gene Summary for TCEAL8 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEAL8 Gene

TCEAL8 (Transcription Elongation Factor A (SII)-Like 8) is a Protein Coding gene. An important paralog of this gene is TCEAL7.

UniProtKB/Swiss-Prot for TCEAL8 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL8 Gene

Genomics for TCEAL8 Gene

Genomic Location for TCEAL8 Gene

Start:
103,252,995 bp from pter
End:
103,255,203 bp from pter
Size:
2,209 bases
Orientation:
Minus strand

Genomic View for TCEAL8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEAL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL8 Gene

Regulatory Elements for TCEAL8 Gene

Proteins for TCEAL8 Gene

  • Protein details for TCEAL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYN2-TCAL8_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 8
    Protein Accession:
    Q8IYN2
    Secondary Accessions:

    Protein attributes for TCEAL8 Gene

    Size:
    117 amino acids
    Molecular mass:
    13616 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCEAL8 Gene

Proteomics data for TCEAL8 Gene at MOPED

Post-translational modifications for TCEAL8 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys62

Other Protein References for TCEAL8 Gene

No data available for DME Specific Peptides for TCEAL8 Gene

Domains for TCEAL8 Gene

Protein Domains for TCEAL8 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TCAL8_HUMAN
Family:
  • Belongs to the TFS-II family. TFA subfamily.:
    • Q8IYN2
genes like me logo Genes that share domains with TCEAL8: view

No data available for Gene Families for TCEAL8 Gene

Function for TCEAL8 Gene

Molecular function for TCEAL8 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TCEAL8 Gene

Localization for TCEAL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEAL8 Gene COMPARTMENTS Subcellular localization image for TCEAL8 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TCEAL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCEAL8: view

Pathways for TCEAL8 Gene

SuperPathways for TCEAL8 Gene

No Data Available

Interacting Proteins for TCEAL8 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000353093%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000339007%0d%0a
Selected Interacting proteins: ENSP00000353093 Q8IYN2-TCAL8_HUMAN for TCEAL8 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TCEAL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCEAL8: view

No data available for Pathways by source for TCEAL8 Gene

Transcripts for TCEAL8 Gene

mRNA/cDNA for TCEAL8 Gene

Unigene Clusters for TCEAL8 Gene

Transcription elongation factor A (SII)-like 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1:
SP2:
SP3: - -

Relevant External Links for TCEAL8 Gene

GeneLoc Exon Structure for
TCEAL8
ECgene alternative splicing isoforms for
TCEAL8

Expression for TCEAL8 Gene

mRNA expression in normal human tissues for TCEAL8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TCEAL8 Gene

SOURCE GeneReport for Unigene cluster for TCEAL8 Gene Hs.389734

genes like me logo Genes that share expressions with TCEAL8: view

Orthologs for TCEAL8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL8 36
  • 99.72 (n)
  • 100 (a)
TCEAL8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCEAL8 36
  • 93.45 (n)
  • 92.31 (a)
TCEAL8 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 81 (a)
OneToMany
-- 37
  • 93 (a)
OneToMany
TCEAL8 36
  • 92.88 (n)
  • 93.16 (a)
mouse
(Mus musculus)
Mammalia Tceal8 36
  • 79.49 (n)
  • 72.65 (a)
Tceal8 16
Tceal8 37
  • 73 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tceal8 36
  • 80.34 (n)
  • 72.65 (a)
Species with no ortholog for TCEAL8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL8 Gene

ENSEMBL:
Gene Tree for TCEAL8 (if available)
TreeFam:
Gene Tree for TCEAL8 (if available)

Paralogs for TCEAL8 Gene

Paralogs for TCEAL8 Gene

Selected SIMAP similar genes for TCEAL8 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TCEAL8 Gene

genes like me logo Genes that share paralogs with TCEAL8: view

Variants for TCEAL8 Gene

Sequence variations from dbSNP and Humsavar for TCEAL8 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3887116 -- 103,252,630(+) CGGTG(A/G)GGTTT downstream-variant-500B
rs4596815 -- 103,253,613(+) TATTA(G/T)GCAAA utr-variant-3-prime
rs5987713 -- 103,256,987(+) TAAAT(G/T)ATTTC upstream-variant-2KB
rs6621636 -- 103,257,112(+) CTGAG(C/T)AGTAT upstream-variant-2KB
rs17285060 -- 103,255,949(+) TTTCA(C/T)TGATG upstream-variant-2KB

Relevant External Links for TCEAL8 Gene

HapMap Linkage Disequilibrium report
TCEAL8
Locus Specific Mutation Databases (LSDB)
TCEAL8

No data available for Structural Variations from Database of Genomic Variants (DGV) for TCEAL8 Gene

Disorders for TCEAL8 Gene

No disorders were found for TCEAL8 Gene.

No data available for UniProtKB/Swiss-Prot for TCEAL8 Gene

Publications for TCEAL8 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  3. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3
  4. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PMID: 18624398) Wang J. … He F. (J. Proteome Res. 2008) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for TCEAL8 Gene

Sources for TCEAL8 Gene

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