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Aliases for TCEAL8 Gene

Aliases for TCEAL8 Gene

  • Transcription Elongation Factor A Like 8 2 3 5
  • Transcription Elongation Factor S-II Protein-Like 8 3 4
  • Transcription Elongation Factor A (SII)-Like 8 2 3
  • TCEA-Like Protein 8 3 4
  • Transcription Elongation Factor A Protein-Like 8 3
  • WEX3 3

External Ids for TCEAL8 Gene

Previous GeneCards Identifiers for TCEAL8 Gene

  • GC0XM102314
  • GC0XM102394
  • GC0XM102507
  • GC0XM092171

Summaries for TCEAL8 Gene

Entrez Gene Summary for TCEAL8 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEAL8 Gene

TCEAL8 (Transcription Elongation Factor A Like 8) is a Protein Coding gene. An important paralog of this gene is TCEAL7.

UniProtKB/Swiss-Prot for TCEAL8 Gene

  • May be involved in transcriptional regulation.

Additional gene information for TCEAL8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL8 Gene

Genomics for TCEAL8 Gene

GeneHancer (GH) Regulatory Elements for TCEAL8 Gene

Promoters and enhancers for TCEAL8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI103253 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.5 494 2.8 PKNOX1 ATF1 SIN3A FEZF1 ZNF48 ETS1 TCF12 ZNF143 ATF7 SP3 TCEAL8 BEX1 GC0XM103234
GH0XI103214 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 12.7 +39.4 39441 2.6 HDGF ATF1 YY1 POLR2B GLIS2 ATF7 SP3 YY2 REST ATF4 BEX4 TCEAL8 LOC100420653 BEX1 BEX2 GC0XM103234
GH0XI103151 Enhancer 1.2 Ensembl ENCODE 10.5 +102.9 102894 1.3 ARNT NEUROD1 FEZF1 GLI4 BRCA1 ZNF2 ZBTB7B TCF12 ZNF121 GLIS2 GPRASP1 BEX4 TCEAL3 ELF2P1 TMSB15B ZCCHC18 GPRASP2 BEX3 TCEAL7 TCEAL1
GH0XI103441 Enhancer 0.6 Ensembl ENCODE 11.1 -187.2 -187198 1.7 JUN ZNF547 BEX4 BEX3 ENSG00000234405 LOC100420653 TCEAL8 PIR37216 PIR62779 LL0XNC01-250H12.3
GH0XI103438 Enhancer 0.5 ENCODE 11.1 -185.0 -185001 2.6 TCF12 NCOR1 TEAD4 IKZF1 TAL1 CBFA2T3 CBFA2T2 BEX4 BEX3 ENSG00000234405 LOC100420653 TCEAL8 PIR37216 PIR62779 LL0XNC01-250H12.3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCEAL8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCEAL8 gene promoter:

Genomic Locations for TCEAL8 Gene

Genomic Locations for TCEAL8 Gene
chrX:103,252,995-103,255,203
(GRCh38/hg38)
Size:
2,209 bases
Orientation:
Minus strand
chrX:102,507,923-102,510,131
(GRCh37/hg19)

Genomic View for TCEAL8 Gene

Genes around TCEAL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL8 Gene

Proteins for TCEAL8 Gene

  • Protein details for TCEAL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYN2-TCAL8_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 8
    Protein Accession:
    Q8IYN2

    Protein attributes for TCEAL8 Gene

    Size:
    117 amino acids
    Molecular mass:
    13616 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCEAL8 Gene

Post-translational modifications for TCEAL8 Gene

Other Protein References for TCEAL8 Gene

No data available for DME Specific Peptides for TCEAL8 Gene

Domains & Families for TCEAL8 Gene

Gene Families for TCEAL8 Gene

Protein Domains for TCEAL8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYN2

UniProtKB/Swiss-Prot:

TCAL8_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL8: view

Function for TCEAL8 Gene

Molecular function for TCEAL8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for TCEAL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050699 WW domain binding IBA --
genes like me logo Genes that share ontologies with TCEAL8: view

Phenotypes for TCEAL8 Gene

genes like me logo Genes that share phenotypes with TCEAL8: view

Animal Model Products

miRNA for TCEAL8 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEAL8 Gene

Localization for TCEAL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEAL8 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TCEAL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TCEAL8: view

Pathways & Interactions for TCEAL8 Gene

SuperPathways for TCEAL8 Gene

No Data Available

Interacting Proteins for TCEAL8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000353093%0d%0a9606.ENSP00000362616%0d%0a
Selected Interacting proteins: ENSP00000353093 Q8IYN2-TCAL8_HUMAN for TCEAL8 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TCEAL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
genes like me logo Genes that share ontologies with TCEAL8: view

No data available for Pathways by source and SIGNOR curated interactions for TCEAL8 Gene

Drugs & Compounds for TCEAL8 Gene

No Compound Related Data Available

Transcripts for TCEAL8 Gene

mRNA/cDNA for TCEAL8 Gene

Unigene Clusters for TCEAL8 Gene

Transcription elongation factor A (SII)-like 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1:
SP2:
SP3: - -

Relevant External Links for TCEAL8 Gene

GeneLoc Exon Structure for
TCEAL8
ECgene alternative splicing isoforms for
TCEAL8

Expression for TCEAL8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCEAL8 Gene

Protein differential expression in normal tissues from HIPED for TCEAL8 Gene

This gene is overexpressed in NK cells (40.7), Fetal gut (20.8), and Platelet (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCEAL8 Gene



Protein tissue co-expression partners for TCEAL8 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCEAL8 Gene:

TCEAL8

SOURCE GeneReport for Unigene cluster for TCEAL8 Gene:

Hs.389734

Evidence on tissue expression from TISSUES for TCEAL8 Gene

  • Liver(4.3)
  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with TCEAL8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEAL8 Gene

Orthologs for TCEAL8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL8 33 34
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia TCEAL8 33 34
  • 93.45 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 93 (a)
OneToMany
TCEAL8 33
  • 92.88 (n)
-- 34
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tceal8 33
  • 80.34 (n)
mouse
(Mus musculus)
Mammalia Tceal8 33 16 34
  • 79.49 (n)
Species where no ortholog for TCEAL8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL8 Gene

ENSEMBL:
Gene Tree for TCEAL8 (if available)
TreeFam:
Gene Tree for TCEAL8 (if available)

Paralogs for TCEAL8 Gene

Paralogs for TCEAL8 Gene

(3) SIMAP similar genes for TCEAL8 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TCEAL8 Gene

genes like me logo Genes that share paralogs with TCEAL8: view

Variants for TCEAL8 Gene

Sequence variations from dbSNP and Humsavar for TCEAL8 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1004376515 -- 103,253,967(-) A/C coding_sequence_variant, missense_variant
rs1006805737 -- 103,253,577(-) T/A/G 3_prime_UTR_variant
rs1007443776 -- 103,254,380(-) C/G intron_variant
rs1008484324 -- 103,256,631(-) GAGAGAGAG/GAGAG upstream_transcript_variant
rs1008944785 -- 103,256,597(-) C/A upstream_transcript_variant

Variation tolerance for TCEAL8 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCEAL8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEAL8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL8 Gene

Disorders for TCEAL8 Gene

Additional Disease Information for TCEAL8

No disorders were found for TCEAL8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL8 Gene

Publications for TCEAL8 Gene

  1. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter EE … Ponting CP (BMC evolutionary biology 2005) 2 3 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58

Products for TCEAL8 Gene

Sources for TCEAL8 Gene

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