TCEAL8 Gene
protein-coding GIFtS: 45
GCID: GC0XM102507
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|
transcription elongation factor A (SII)-like 8
| |
Aliases
for TCEAL8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transcription Elongation Factor A (SII)-Like 81 2 | | Transcription Elongation Factor S-II Protein-Like 82 3 | | TCEA-Like Protein 82 3 | | MGC454001 | | Transcription Elongation Factor A Protein-Like 82 |
Export aliases for TCEAL8 gene to outside databasesPrevious GC identifers: GC0XM102314 GC0XM102394 GC0XM092171 |
Summaries
for TCEAL8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TCEAL8:
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of thisfamily contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promotercontext-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results inmultiple transcript variants encoding a single isoform. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TCAL8_HUMAN, Q8IYN2Function: May be involved in transcriptional regulation
|
Genomic Views
for TCEAL8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TCEAL8 gene promoter:
p53 AML1a FOXO3 FOXO3b MZF-1 N-Myc POU2F1 FOXJ2 (long isoform) FOXO3a FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCEAL8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEAL8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.1 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22.1TCEAL8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM102507: view genomic region
(about GC identifiers)
Start:
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102,507,923 bp from pter |
End:
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102,510,131 bp from pter |
Size:
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2,209 bases |
Orientation:
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minus strand |
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Proteins
for TCEAL8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TCAL8_HUMAN, Q8IYN2 (See
protein sequence)Recommended Name: Transcription elongation factor A protein-like 8 Size: 117 amino acids; 13616 Da
Subcellular location: Nucleus (Probable)Explore the universe of human proteins at neXtProt for TCEAL8: NX_Q8IYN2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYN2
TCEAL8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001006685.1 NP_699164.1
ENSEMBL proteins: ENSP00000353093 ENSP00000361770 ENSP00000390880
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
TCEAL8 for ontologies About GeneDecksing
TCEAL8 Antibody Products:
Assay Products for TCEAL8: |
Protein
Domains /
Families
for TCEAL8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCEAL8 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IYN2ProtoNet protein and cluster: Q8IYN2 UniProtKB/Swiss-Prot: TCAL8_HUMAN, Q8IYN2Similarity: Belongs to the TFS-II family. TFA subfamily |
Function
for TCEAL8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TCAL8_HUMAN, Q8IYN2Function: May be involved in transcriptional regulation
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEAL8 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL8 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003746 | translation elongation factor activity |
-- | -- |
TCEAL8 for ontologies About GeneDecksing
|
Pathways & Interactions
for TCEAL8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCEAL8
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for TCEAL8 (Q8IYN23 ENSP000003530934) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
TCEAL8 for ontologies About GeneDecksing
|
Drugs & Compounds
for TCEAL8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TCEAL8
Search CenterWatch for drugs/clinical trials and news about TCEAL8 / TCAL8
|
Transcripts
for TCEAL8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCEAL8 gene (2 alternative transcripts): NM_001006684.1 NM_153333.2 Unigene Cluster for TCEAL8: Transcription elongation factor A (SII)-like 8 Hs.389734 [show with all ESTs]Unigene Representative Sequence: BF6739623 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000360000 ENST00000372685(uc004ejx.3 uc004ejy.3) ENST00000451678
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCEAL8 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEAL8 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TCEAL8 (NM_153333) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCEAL8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEAL8 |
Additional cDNA sequence: AK026349.1 AL833632.1 BC035573.1 8 DOTS entries: DT.418030 DT.91689144 DT.100803085 DT.91749246 DT.91749238 DT.121305812 DT.91749237 DT.95300929 24/260 AceView cDNA sequences (see all 260): BE327945 AA700191 AI380330 AA774643 BE018750 CA312202 CR622012 Z44920 BU628530 AA507576 CA413725 BM454855 BM457049 BQ030216 AI375234 BE885627 CA411971 AA970699 AA548984 BM693509 BU597910 BQ019528 AI078020 F03880
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL8 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c |
|---|
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| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for TCEAL8
|
Expression
for TCEAL8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCEAL8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTAAAGTA
About this image
See TCEAL8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCEAL8
SOURCE GeneReport for Unigene cluster: Hs.389734
SABiosciences Custom PCR Arrays for TCEAL8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCEAL8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TCEAL8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCEAL8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEAL8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL8 |
Orthologs
for TCEAL8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for TCEAL8 (if available)
TreeFam Gene Tree for TCEAL8 (if available) |
Paralogs
for TCEAL8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TCEAL8 gene
- WBP52 TCEAL12 TCEAL72
5 SIMAP similar genes for TCEAL8 using alignment to 2 protein entries: TCAL8_HUMAN (see all proteins):TCEAL5 TCEAL1 TCEAL6 WBP5 TCEAL7
TCEAL8 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TCEAL8
PGOHUM00000237643
|
Genomic Variants
for TCEAL8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TCEAL8 (102507923 - 102510131 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TCEAL8: --
Locus Specific Mutation Databases (LSDB): TCEAL8
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCEAL8 |
|
Disorders
/ Diseases
for TCEAL8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TCEAL8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCEAL8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TCEAL8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)1 Wang J....He F. (2008)
- Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR. (PubMed id 10051408)1 Pillutla R.C.... Shatkin A.J. (1999)
|
External Searches for TCEAL8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TCEAL8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCEAL8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCEAL8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TCEAL8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TCEAL8 gene:
Search GeneIP for patents involving TCEAL8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCEAL8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | TCEAL8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL8 |
|  |  |  | | | | ThermoFisher Antibody for TCEAL8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEAL8 |
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