TCEAL8 Gene
protein-coding GIFtS: 45
GCID: GC0XM102507
|
|
Transcription Elongation Factor A (SII)-Like 8
| |
Aliases
for TCEAL8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| Transcription Elongation Factor A (SII)-Like 81 2 | | Transcription Elongation Factor S-II Protein-Like 82 3 | | TCEA-Like Protein 82 3 | | WEX32 | | Transcription Elongation Factor A Protein-Like 82 |
Export aliases for TCEAL8 gene to outside databasesPrevious GC identifers: GC0XM102314 GC0XM102394 GC0XM092171 |
Summaries
for TCEAL8 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Entrez Gene summary for TCEAL8 Gene:
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of
this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a
promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing
results in multiple transcript variants encoding a single isoform. (provided by RefSeq, Jul 2008)
GeneCards Summary for TCEAL8 Gene:
TCEAL8 (transcription elongation factor A (SII)-like 8) is a protein-coding gene. An important paralog of this gene is TCEAL7.
UniProtKB/Swiss-Prot: TCAL8_HUMAN, Q8IYN2Function: May be involved in transcriptional regulation
|
Genomic Views
for TCEAL8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000023.11 NC_018934.2 NT_011651.18
Regulatory elements:
 Regulatory transcription factor binding sites in the TCEAL8 gene promoter:
p53 AML1a FOXO3 FOXO3b MZF-1 N-Myc POU2F1 FOXJ2 (long isoform) FOXO3a FOXJ2
Other transcription factors
Search Chromatin IP Primers for TCEAL8
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCEAL8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.1 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22.1TCEAL8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM102507: view genomic region
(about GC identifiers)
Start:
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102,507,923 bp from pter |
End:
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102,510,131 bp from pter |
Size:
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2,209 bases |
Orientation:
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minus strand |
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Proteins
for TCEAL8 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
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UniProtKB/Swiss-Prot: TCAL8_HUMAN, Q8IYN2 (See
protein sequence)Recommended Name: Transcription elongation factor A protein-like 8 Size: 117 amino acids; 13616 DaExplore the universe of human proteins at neXtProt for TCEAL8: NX_Q8IYN2
Explore proteomics data for TCEAL8 at MOPED
Post-translational modifications:  Ubiquitination2 at Lys62 Modification sites at PhosphoSitePlus
See TCEAL8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins (2 alternative transcripts):
NP_001006685.1 NP_699164.1
ENSEMBL proteins: ENSP00000353093 ENSP00000361770 ENSP00000390880
TCEAL8 Human Recombinant
Protein Products:TCEAL8 Antibody
Products:TCEAL8 Assay Products: |
Domains /
Families
for TCEAL8 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | 2 InterPro protein domains:Graphical View of Domain Structure for InterPro Entry Q8IYN2 ProtoNet protein and cluster: Q8IYN2 UniProtKB/Swiss-Prot: TCAL8_HUMAN, Q8IYN2Similarity: Belongs to the TFS-II family. TFA subfamily
TCEAL8 for domains About GeneDecksing
|
Function
for TCEAL8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Molecular Function:
UniProtKB/Swiss-Prot Summary: TCAL8_HUMAN, Q8IYN2Function: May be involved in transcriptional regulationAnimal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for TCEAL8
| | | Predesigned siRNA for gene silencing in human, mouse, rat TCEAL8 |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for TCEAL8 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for TCEAL8  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL8 |
Localization
for TCEAL8 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot TCAL8_HUMAN, Q8IYN2: Nucleus (Probable)Subcellular locations from COMPARTMENTS:
| Compartment | Confidence |
|---|
|
| nucleus | 4 | | cytosol | 2 | | extracellular | 1 |
Gene Ontology (GO): 1 cellular component term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
TCEAL8 for ontologies About GeneDecksing
|
Pathways & Interactions
for TCEAL8 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
About This Section
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCEAL8
Interactions:
Search GeneGlobe Interaction Network for TCEAL8
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for TCEAL8 (Q8IYN23 ENSP000003530934) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-templated |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-templated |
IEA | -- |
TCEAL8 for ontologies About GeneDecksing
|
Drugs & Compounds
for TCEAL8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for TCEAL8 (TCAL8)
|
Transcripts
for TCEAL8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for TCEAL8 gene (2 alternative transcripts): NM_001006684.1 NM_153333.2 Unigene Cluster for TCEAL8: Transcription elongation factor A (SII)-like 8 Hs.389734 [show with all ESTs]Unigene Representative Sequence: BF6739623 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000360000 ENST00000372685(uc004ejx.3 uc004ejy.3) ENST00000451678
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for TCEAL8
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat TCEAL8 |
Primer
Products: | | OriGene qPCR primer pairs and template standards for TCEAL8
OriGene qSTAR qPCR primer pairs in human, mouse for TCEAL8
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TCEAL8 | | | QuantiTect SYBR Green Assays in human, mouse, rat TCEAL8 | | | QuantiFast Probe-based Assays in human, mouse, rat TCEAL8 |
Additional mRNA sequence: AK026349.1 AL833632.1 BC035573.1 8 DOTS entries: DT.418030 DT.91689144 DT.100803085 DT.91749246 DT.91749238 DT.121305812 DT.91749237 DT.95300929 Selected AceView cDNA sequences (see all 260): BM717832 CA413791 AW583269 BU785705 AI092708 CA310769 AI129630 BQ007597 CB051670 BQ071743 AI028462 CA411971 BM310985 AA778937 AA774643 CB147964 BM693509 AA507576 AA700191 BM981717 BF725944 CA424198 AA907692 AI380330
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL8 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c |
|---|
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| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for TCEAL8
|
Expression
for TCEAL8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TCEAL8 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTGTAAAGTA
About this image TCEAL8 Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
SOURCE GeneReport for Unigene cluster: Hs.389734
Custom PCR Arrays for TCEAL8
Primer
Products: | | OriGene qPCR primer pairs and template standards for TCEAL8
OriGene qSTAR qPCR primer pairs in human, mouse for TCEAL8
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TCEAL8 | | | QuantiTect SYBR Green Assays in human, mouse, rat TCEAL8 | | | QuantiFast Probe-based Assays in human, mouse, rat TCEAL8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL8 |
Orthologs
for TCEAL8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of human and mouse.
Orthologs for TCEAL8 gene from Selected species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tceal81 , 5 |
transcription elongation factor A (SII)-like 81, 5 |
79.49(n)1
72.65(a)1 |
|
X (57.40 cM)5
666841 NM_025703.31 NP_079979.21
1361700815 |
ENSEMBL Gene Tree for TCEAL8 (if available)
TreeFam Gene Tree for TCEAL8 (if available) |
Paralogs
for TCEAL8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for TCEAL8 gene
- TCEAL72
3 SIMAP similar genes for TCEAL8 using alignment to 2 protein entries: TCAL8_HUMAN (see all proteins):TCEAL5 TCEAL1 TCEAL6
TCEAL8 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TCEAL8
PGOHUM00000237643
|
Genomic Variants
for TCEAL8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TCEAL8 (102507923 - 102510131 bp)
Structural Variations
Database of Genomic Variants (DGV) variations for TCEAL8: --
Locus Specific Mutation Databases (LSDB): TCEAL8
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing TCEAL8 |
|
Disorders
/ Diseases
for TCEAL8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
TryGeneCards Plus | -- |
Publications
for TCEAL8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for TCEAL8 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TCEAL8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
- Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PubMed id 16221301)1, 3 Winter E.E. and Ponting C.P. (BMC Evol. Biol. 2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
- Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
- Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
- Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)1 Wang J....He F. (J. Proteome Res. 2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
- Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR. (PubMed id 10051408)1 Pillutla R.C.... Shatkin A.J. (Genomics 1999)
|
External Searches for TCEAL8 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing TCEAL8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing TCEAL8 gene
(According to HUGE)
About This Section
TryGeneCards Plus | -- |
Specialized Databases showing TCEAL8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for TCEAL8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for TCEAL8 gene:
Search GeneIP for patents involving TCEAL8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCEAL8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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 | |
 |
| | | | |
 |
 |
|  | Block miRNA regulation of human, mouse, rat TCEAL8 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing TCEAL8 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCEAL8 | | Predesigned siRNA for gene silencing in human, mouse, rat TCEAL8 | | | QuantiFast Probe-based Assays in human, mouse, rat TCEAL8 | | QuantiTect SYBR Green Assays in human, mouse, rat TCEAL8 | | | Custom PCR Arrays for TCEAL8 | | Search Chromatin IP Primers for TCEAL8 | | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TCEAL8 | | Search GeneGlobe Interaction Network for TCEAL8 | | | Regulatory tfbs in TCEAL8 promoter |
| |
 |  |  |  | |
| | | |  |  |  |
 | | | | | Recombinant Protein for TCEAL8 |
| |
 |
 |
 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL8 |
| |  |  |  |  | | | ThermoFisher Antibody for TCEAL8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEAL8 |
| | | | LSBio Antibodies in human, mouse, rat for TCEAL8 |
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