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Aliases for TCEAL7 Gene

Aliases for TCEAL7 Gene

  • Transcription Elongation Factor A (SII)-Like 7 2 3
  • Transcription Elongation Factor S-II Protein-Like 7 3 4
  • TCEA-Like Protein 7 3 4
  • Transcription Elongation Factor A Protein-Like 7 3
  • MPMGp800C04260Q003 3
  • WEX5 3

External Ids for TCEAL7 Gene

Summaries for TCEAL7 Gene

GeneCards Summary for TCEAL7 Gene

TCEAL7 (Transcription Elongation Factor A (SII)-Like 7) is a Protein Coding gene. Diseases associated with TCEAL7 include gastric adenocarcinoma. An important paralog of this gene is TCEAL8.

UniProtKB/Swiss-Prot for TCEAL7 Gene

  • Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL7 Gene

Genomics for TCEAL7 Gene

Genomic Location for TCEAL7 Gene

Start:
103,330,186 bp from pter
End:
103,332,326 bp from pter
Size:
2,141 bases
Orientation:
Plus strand

Genomic View for TCEAL7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEAL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL7 Gene

Regulatory Elements for TCEAL7 Gene

Proteins for TCEAL7 Gene

  • Protein details for TCEAL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRU2-TCAL7_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 7
    Protein Accession:
    Q9BRU2
    Secondary Accessions:
    • B3KSV2
    • Q96AT4

    Protein attributes for TCEAL7 Gene

    Size:
    100 amino acids
    Molecular mass:
    12324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCEAL7 Gene

Proteomics data for TCEAL7 Gene at MOPED

Post-translational modifications for TCEAL7 Gene

No Post-translational modifications

Other Protein References for TCEAL7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCEAL7 Gene

Domains for TCEAL7 Gene

Protein Domains for TCEAL7 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TCAL7_HUMAN
Family:
  • Belongs to the TFS-II family. TFA subfamily.:
    • Q9BRU2
genes like me logo Genes that share domains with TCEAL7: view

No data available for Gene Families for TCEAL7 Gene

Function for TCEAL7 Gene

Molecular function for TCEAL7 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines.

Phenotypes for TCEAL7 Gene

GenomeRNAi human phenotypes for TCEAL7:
genes like me logo Genes that share phenotypes with TCEAL7: view

miRNA for TCEAL7 Gene

miRTarBase miRNAs that target TCEAL7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TCEAL7 Gene

Localization for TCEAL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEAL7 Gene COMPARTMENTS Subcellular localization image for TCEAL7 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TCEAL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with TCEAL7: view

Pathways for TCEAL7 Gene

SuperPathways for TCEAL7 Gene

No Data Available

Interacting Proteins for TCEAL7 Gene

Selected Interacting proteins: Q9BRU2-TCAL7_HUMAN for TCEAL7 Gene via MINT I2D

Symbol External ID(s) Details
CSNK2B

Gene Ontology (GO) - Biological Process for TCEAL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 19966855
GO:0045892 negative regulation of transcription, DNA-templated IDA 18806825
genes like me logo Genes that share ontologies with TCEAL7: view

No data available for Pathways by source for TCEAL7 Gene

Transcripts for TCEAL7 Gene

mRNA/cDNA for TCEAL7 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(74) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCEAL7 Gene

Transcription elongation factor A (SII)-like 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for TCEAL7 Gene

GeneLoc Exon Structure for
TCEAL7
ECgene alternative splicing isoforms for
TCEAL7

Expression for TCEAL7 Gene

mRNA expression in normal human tissues for TCEAL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCEAL7 Gene

This gene is overexpressed in Brain - Hypothalamus (4.6), Brain - Spinal cord (cervical c-1) (4.1), and Brain - Anterior cingulate cortex (BA24) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TCEAL7 Gene

SOURCE GeneReport for Unigene cluster for TCEAL7 Gene Hs.21861

mRNA Expression by UniProt/SwissProt for TCEAL7 Gene

Q9BRU2-TCAL7_HUMAN
Tissue specificity: Highly expressed in normal and fetal brain tissues, and weakly expressed in uterus and ovary. Down-regulated in epithelial ovarian, cervical, prostate, breast, brain and lung cancer cell lines and in brain and ovarian tumors.
genes like me logo Genes that share expressions with TCEAL7: view

Orthologs for TCEAL7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL7 36
  • 100 (n)
  • 100 (a)
TCEAL7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCEAL7 36
  • 90 (n)
  • 85 (a)
TCEAL7 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCEAL7 36
  • 94.67 (n)
  • 96 (a)
TCEAL7 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tceal7 36
  • 85.37 (n)
  • 75.51 (a)
Tceal7 16
Tceal7 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tceal7 36
  • 85.71 (n)
  • 80.61 (a)
Species with no ortholog for TCEAL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL7 Gene

ENSEMBL:
Gene Tree for TCEAL7 (if available)
TreeFam:
Gene Tree for TCEAL7 (if available)

Paralogs for TCEAL7 Gene

Paralogs for TCEAL7 Gene

Selected SIMAP similar genes for TCEAL7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TCEAL7: view

Variants for TCEAL7 Gene

Sequence variations from dbSNP and Humsavar for TCEAL7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1045761 -- 103,330,974(+) GTTTG(C/G)AGGTC utr-variant-5-prime
rs5945971 -- 103,328,477(+) tcagc(C/T)tcacc upstream-variant-2KB
rs11409713 -- 103,328,534(+) TCAGG(-/C)CTGCC upstream-variant-2KB
rs11409714 -- 103,328,537(+) GGCTG(-/C)CCTTG upstream-variant-2KB
rs11546690 -- 103,330,966(+) TCCTT(C/T)TTGTT utr-variant-5-prime

Relevant External Links for TCEAL7 Gene

HapMap Linkage Disequilibrium report
TCEAL7

No data available for Structural Variations from Database of Genomic Variants (DGV) for TCEAL7 Gene

Disorders for TCEAL7 Gene

(1) MalaCards Diseases for TCEAL7 Gene

Search for TCEAL7 Gene in MalaCards »

Relevant External Links for TCEAL7

Genetic Association Database (GAD)
TCEAL7
Human Genome Epidemiology (HuGE) Navigator
TCEAL7
genes like me logo Genes that share disorders with TCEAL7: view

No data available for UniProtKB/Swiss-Prot for TCEAL7 Gene

Publications for TCEAL7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. TCEAL7, a putative tumor suppressor gene, negatively regulates NF- kappaB pathway. (PMID: 19966855) Rattan R. … Shridhar V. (Oncogene 2010) 3 4 23
  3. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for TCEAL7 Gene

Sources for TCEAL7 Gene

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