TCEAL7 Gene
protein-coding GIFtS: 48
GCID: GC0XP102585
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|
transcription elongation factor A (SII)-like 7
| |
Aliases
for TCEAL7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transcription Elongation Factor A (SII)-Like 71 2 | | Transcription Elongation Factor S-II Protein-Like 72 3 | | TCEA-Like Protein 72 3 | | MGC239471 | | MPMGp800C04260Q0032 | | Transcription Elongation Factor A Protein-Like 72 |
Export aliases for TCEAL7 gene to outside databasesPrevious GC identifers: GC0XP102391 GC0XP092248 |
Summaries
for TCEAL7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TCAL7_HUMAN, Q9BRU2Function: Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulatingtranscriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing MycE-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptaseexpression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive celllines
|
Genomic Views
for TCEAL7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TCEAL7 gene promoter:
Nkx3-1 Max1 Nkx3-1 v4 Nkx3-1 v1 XBP-1 Max Nkx3-1 v2 Nkx3-1 v3 c-Myc Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCEAL7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEAL7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.1 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22.1TCEAL7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP102585: view genomic region
(about GC identifiers)
Start:
|
102,585,114 bp from pter |
End:
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102,587,254 bp from pter |
Size:
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2,141 bases |
Orientation:
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plus strand |
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Proteins
for TCEAL7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TCAL7_HUMAN, Q9BRU2 (See
protein sequence)Recommended Name: Transcription elongation factor A protein-like 7 Size: 100 amino acids; 12324 Da
Subcellular location: Nucleus
Secondary accessions: B3KSV2 Q96AT4Explore the universe of human proteins at neXtProt for TCEAL7: NX_Q9BRU2
TCEAL7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689491.1
ENSEMBL proteins: ENSP00000329794 ENSP00000361751
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
TCEAL7 for ontologies About GeneDecksing
TCEAL7 Antibody Products:
Assay Products for TCEAL7: |
Protein
Domains /
Families
for TCEAL7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCEAL7 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BRU2ProtoNet protein and cluster: Q9BRU2 UniProtKB/Swiss-Prot: TCAL7_HUMAN, Q9BRU2Similarity: Belongs to the TFS-II family. TFA subfamily |
Function
for TCEAL7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TCAL7_HUMAN, Q9BRU2Function: Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulatingtranscriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing MycE-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptaseexpression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive celllines
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCEAL7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEAL7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL7 |
1 GenomeRNAi human phenotype for TCEAL7:
|
Pathways & Interactions
for TCEAL7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCEAL7
1 Interacting protein for TCEAL7 (Q9BRU22, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
IDA | 19966855 | | GO:0045892 | negative regulation of transcription, DNA-dependent |
IDA | 18806825 |
TCEAL7 for ontologies About GeneDecksing
|
Drugs & Compounds
for TCEAL7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TCEAL7
Search CenterWatch for drugs/clinical trials and news about TCEAL7 / TCAL7
|
Transcripts
for TCEAL7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCEAL7 gene: NM_152278.3 Unigene Cluster for TCEAL7: Transcription elongation factor A (SII)-like 7 Hs.21861 [show with all ESTs]Unigene Representative Sequence: BF2194872 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000332431(uc004ekc.2) ENST00000372666
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCEAL7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEAL7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TCEAL7 (NM_152278) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCEAL7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEAL7 |
Additional cDNA sequence: AJ297363.1 BC005988.1 BC016786.1 4 DOTS entries: DT.112828 DT.100022100 DT.100022101 DT.121320806 24/74 AceView cDNA sequences (see all 74): AI363382 BQ878422 BX094143 BM726387 CR612143 AA779400 CD677485 BE222914 AI753521 BX332477 BF591534 AK094400 CD677529 AW974650 CD511388 AL530904 AA404392 BC016786 BM544193 BM921484 BI551917 AV723038 BI821178 NM_152278
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL7 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b |
|---|
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for TCEAL7
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Expression
for TCEAL7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCEAL7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAAATGCT
About this image
See TCEAL7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCEAL7
SOURCE GeneReport for Unigene cluster: Hs.21861
UniProtKB/Swiss-Prot: TCAL7_HUMAN, Q9BRU2Tissue specificity: Highly expressed in normal and fetal brain tissues, and weakly expressed in uterus and ovary.Down-regulated in epithelial ovarian, cervical, prostate, breast, brain and lung cancer cell lines and in brain andovarian tumors
SABiosciences Custom PCR Arrays for TCEAL7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCEAL7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TCEAL7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCEAL7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEAL7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL7 |
Orthologs
for TCEAL7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for TCEAL7 (if available)
TreeFam Gene Tree for TCEAL7 (if available) |
Paralogs
for TCEAL7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TCEAL7 gene
- WBP52 TCEAL12 TCEAL82
5 SIMAP similar genes for TCEAL7 using alignment to 2 protein entries: TCAL7_HUMAN (see all proteins):WBP5 TCEAL1 TCEAL6 TCEAL5 TCEAL8
TCEAL7 for paralogs About GeneDecksing
|
Genomic Variants
for TCEAL7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TCEAL7 (102585114 - 102587254 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TCEAL7
2 CNVs: 96861 96862 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCEAL7 |
|
Disorders
/ Diseases
for TCEAL7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCEAL7 for disorders About GeneDecksing
OMIM gene information: 300771
OMIM disorders: --
5  diseases for TCEAL7: About MalaCardsepithelial ovarian cancer ovarian cancer lung cancer cervicitis
prostatitis
Human Genome Epidemiology (HuGE) Navigator: TCEAL7 (1 document)
Export disorders for TCEAL7 gene to outside databases
|
Publications
for TCEAL7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCEAL7 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TCEAL7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
- TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB pathway. (PubMed id 19966855)1, 2, 9 Rattan R....Shridhar V. (2010)
- TCEAL7 inhibition of c-Myc activity in alternative le ngthening of telomeres regulates hTERT expression. (PubMed id 20454512)1, 2 Lafferty-Whyte K....Keith W.N. (2010)
- A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation. (PubMed id 18806825)1, 2 Chien J....Shridhar V. (2008)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer. (PubMed id 19419758)1 Peedicayil A....Goode E.L. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer. (PubMed id 15870691)1 Chien J....Shridhar V. (2005)
|
External Searches for TCEAL7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TCEAL7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCEAL7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCEAL7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TCEAL7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TCEAL7 gene:
Search GeneIP for patents involving TCEAL7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCEAL7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL7 |
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