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Aliases for TCEAL7 Gene

Aliases for TCEAL7 Gene

  • Transcription Elongation Factor A Like 7 2 3 5
  • Transcription Elongation Factor S-II Protein-Like 7 3 4
  • Transcription Elongation Factor A (SII)-Like 7 2 3
  • TCEA-Like Protein 7 3 4
  • Transcription Elongation Factor A Protein-Like 7 3
  • WEX5 3

External Ids for TCEAL7 Gene

Previous GeneCards Identifiers for TCEAL7 Gene

  • GC0XP102391
  • GC0XP102585
  • GC0XP092248

Summaries for TCEAL7 Gene

GeneCards Summary for TCEAL7 Gene

TCEAL7 (Transcription Elongation Factor A Like 7) is a Protein Coding gene. An important paralog of this gene is TCEAL8.

UniProtKB/Swiss-Prot for TCEAL7 Gene

  • Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL7 Gene

Genomics for TCEAL7 Gene

Regulatory Elements for TCEAL7 Gene

Enhancers for TCEAL7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG103151 1.2 Ensembl ENCODE 12.8 -177.9 -177878 1.3 ARNT FEZF1 GLI4 BRCA1 ZNF2 ZBTB7B TCF12 ZNF121 GLIS2 FOS GPRASP1 BEX4 TCEAL3 ELF2P1 ZCCHC18 BEX3 TCEAL7 TCEAL1 BHLHB9 ARMCX5-GPRASP2
GH0XG103920 0.7 Ensembl 12.8 +590.7 590715 0.2 ZFP64 ZBTB11 ZNF426 ZNF394 ZNF623 ZNF781 TBX21 ZNF518A ZNF697 ZNF555 TCEAL3 ZCCHC18 BEX3 TCEAL7 RAB9B BEX4 ELF2P1 TCEAL5 LOC100128594 LOC644261
GH0XG103359 0.7 ENCODE 12.7 +30.1 30054 1.0 PKNOX1 TAL1 ETV1 TCF12 GATA2 FOXK2 ZNF600 PRDM10 TRIM24 ZNF548 TCEAL7 MORF4L2-AS1 TCEAL9 BEX3
GH0XG103428 0.2 ENCODE 12 +98.5 98475 1.0 TCEAL7 PIR37216 PIR62779
GH0XG103329 0.6 ENCODE 0.7 +0.3 257 2.4 ARID1B PKNOX1 GLIS2 POLR2A ZNF692 TAL1 BEX4 TCEAL7 ENSG00000238049
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCEAL7 on UCSC Golden Path with GeneCards custom track

Promoters for TCEAL7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247694 514 1400 TCF12 PKNOX1 POLR2A ZNF692

Genomic Location for TCEAL7 Gene

Chromosome:
X
Start:
103,330,186 bp from pter
End:
103,332,326 bp from pter
Size:
2,141 bases
Orientation:
Plus strand

Genomic View for TCEAL7 Gene

Genes around TCEAL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL7 Gene

Proteins for TCEAL7 Gene

  • Protein details for TCEAL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRU2-TCAL7_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 7
    Protein Accession:
    Q9BRU2
    Secondary Accessions:
    • B3KSV2
    • Q96AT4

    Protein attributes for TCEAL7 Gene

    Size:
    100 amino acids
    Molecular mass:
    12324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCEAL7 Gene

Post-translational modifications for TCEAL7 Gene

No Post-translational modifications

Other Protein References for TCEAL7 Gene

No data available for DME Specific Peptides for TCEAL7 Gene

Domains & Families for TCEAL7 Gene

Gene Families for TCEAL7 Gene

Protein Domains for TCEAL7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRU2

UniProtKB/Swiss-Prot:

TCAL7_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL7: view

Function for TCEAL7 Gene

Molecular function for TCEAL7 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines.
genes like me logo Genes that share phenotypes with TCEAL7: view

Animal Model Products

CRISPR Products

miRNA for TCEAL7 Gene

miRTarBase miRNAs that target TCEAL7

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEAL7 Gene

Localization for TCEAL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEAL7 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TCEAL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18806825
genes like me logo Genes that share ontologies with TCEAL7: view

Pathways & Interactions for TCEAL7 Gene

SuperPathways for TCEAL7 Gene

No Data Available

Interacting Proteins for TCEAL7 Gene

Selected Interacting proteins: Q9BRU2-TCAL7_HUMAN for TCEAL7 Gene via IID MINT

Gene Ontology (GO) - Biological Process for TCEAL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 19966855
GO:0045892 negative regulation of transcription, DNA-templated IDA 18806825
genes like me logo Genes that share ontologies with TCEAL7: view

No data available for Pathways by source and SIGNOR curated interactions for TCEAL7 Gene

Transcripts for TCEAL7 Gene

mRNA/cDNA for TCEAL7 Gene

Unigene Clusters for TCEAL7 Gene

Transcription elongation factor A (SII)-like 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for TCEAL7 Gene

GeneLoc Exon Structure for
TCEAL7
ECgene alternative splicing isoforms for
TCEAL7

Expression for TCEAL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCEAL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCEAL7 Gene

This gene is overexpressed in Brain - Hypothalamus (x4.6), Brain - Spinal cord (cervical c-1) (x4.1), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Protein differential expression in normal tissues from HIPED for TCEAL7 Gene

This gene is overexpressed in Fetal heart (50.9) and Fetal Brain (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TCEAL7 Gene



Protein tissue co-expression partners for TCEAL7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCEAL7 Gene:

TCEAL7

SOURCE GeneReport for Unigene cluster for TCEAL7 Gene:

Hs.21861

mRNA Expression by UniProt/SwissProt for TCEAL7 Gene:

Q9BRU2-TCAL7_HUMAN
Tissue specificity: Highly expressed in normal and fetal brain tissues, and weakly expressed in uterus and ovary. Down-regulated in epithelial ovarian, cervical, prostate, breast, brain and lung cancer cell lines and in brain and ovarian tumors.

Evidence on tissue expression from TISSUES for TCEAL7 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with TCEAL7: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEAL7 Gene

Orthologs for TCEAL7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL7 35 34
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TCEAL7 34 35
  • 94.67 (n)
cow
(Bos Taurus)
Mammalia TCEAL7 34 35
  • 90 (n)
rat
(Rattus norvegicus)
Mammalia Tceal7 34
  • 85.71 (n)
mouse
(Mus musculus)
Mammalia Tceal7 35 16 34
  • 85.37 (n)
OneToOne
Species where no ortholog for TCEAL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL7 Gene

ENSEMBL:
Gene Tree for TCEAL7 (if available)
TreeFam:
Gene Tree for TCEAL7 (if available)

Paralogs for TCEAL7 Gene

Paralogs for TCEAL7 Gene

(4) SIMAP similar genes for TCEAL7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TCEAL7: view

Variants for TCEAL7 Gene

Sequence variations from dbSNP and Humsavar for TCEAL7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000309013 -- 103,329,419(+) AGTTG(C/T)GATCT upstream-variant-2KB
rs1003275773 -- 103,331,991(+) CACTT(C/T)ATTTG utr-variant-3-prime
rs1004289731 -- 103,329,158(+) GGTGG(C/T)TAAAT upstream-variant-2KB
rs1004360232 -- 103,328,350(+) GCAGA(A/C)TGAGC upstream-variant-2KB
rs1005962618 -- 103,332,080(+) ATCTC(-/T)TTTTT utr-variant-3-prime

Variation tolerance for TCEAL7 Gene

Residual Variation Intolerance Score: 63.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEAL7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEAL7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL7 Gene

Disorders for TCEAL7 Gene

Relevant External Links for TCEAL7

Genetic Association Database (GAD)
TCEAL7
Human Genome Epidemiology (HuGE) Navigator
TCEAL7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEAL7

No disorders were found for TCEAL7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL7 Gene

Publications for TCEAL7 Gene

  1. TCEAL7, a putative tumor suppressor gene, negatively regulates NF- kappaB pathway. (PMID: 19966855) Rattan R. … Shridhar V. (Oncogene 2010) 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  3. TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression. (PMID: 20454512) Lafferty-Whyte K. … Keith W.N. (Neoplasia 2010) 3 4 64
  4. Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer. (PMID: 19419758) Peedicayil A. … Goode E.L. (Gynecol. Oncol. 2009) 3 46 64
  5. A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation. (PMID: 18806825) Chien J. … Shridhar V. (Oncogene 2008) 3 4 64

Products for TCEAL7 Gene

Sources for TCEAL7 Gene

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