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TCEAL6 Gene

protein-coding   GIFtS: 40
GCID: GC0XM101394

Transcription Elongation Factor A (SII)-Like 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Elongation Factor A (SII)-Like 61 2     WEX22
Transcription Elongation Factor S-II Protein-Like 62 3     Transcription Elongation Factor A (SII)-Like 32
TCEA-Like Protein 62 3     Transcription Elongation Factor A Protein-Like 62
Tceal32     

External Ids:    HGNC: 245531   Entrez Gene: 1589312   Ensembl: ENSG000002040717   UniProtKB: Q6IPX33   

Export aliases for TCEAL6 gene to outside databases

Previous GC identifers: GC0XM101202 GC0XM101281 GC0XM091203


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TCEAL6 Gene:
TCEAL6 (transcription elongation factor A (SII)-like 6) is a protein-coding gene. An important paralog of this gene is TCEAL4.

UniProtKB/Swiss-Prot: TCAL6_HUMAN, Q6IPX3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCEAL6 gene promoter:
         Max1   TBP   USF1   p53   FOXD3   USF2   USF-1:USF-2   FOXL1   MZF-1   USF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TCEAL6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCEAL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.1

TCEAL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEAL6 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM101394:  view genomic region     (about GC identifiers)

Start:
101,394,933 bp from pter      End:
101,397,942 bp from pter
Size:
3,010 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCAL6_HUMAN, Q6IPX3 (See protein sequence)
Recommended Name: Transcription elongation factor A protein-like 6  
Size: 200 amino acids; 22298 Da
Secondary accessions: Q5H9J8
Alternative splicing: 2 isoforms:  Q6IPX3-1   Q6IPX3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TCEAL6: NX_Q6IPX3

Explore proteomics data for TCEAL6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TCEAL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001006939.2  
    ENSEMBL proteins: 
     ENSP00000361860   ENSP00000361859  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021156 TF_A-like/BEX-like
     IPR010370 TFA

    Graphical View of Domain Structure for InterPro Entry Q6IPX3

    ProtoNet protein and cluster: Q6IPX3

    UniProtKB/Swiss-Prot: TCAL6_HUMAN, Q6IPX3
    Similarity: Belongs to the TFS-II family. TFA subfamily


    Find genes that share domains with TCEAL6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCAL6_HUMAN, Q6IPX3
    Function: May be involved in transcriptional regulation

    Animal Models:

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    SwitchGear 3'UTR luciferase reporter plasmidTCEAL6 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCAL6_HUMAN, Q6IPX3: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with TCEAL6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCEAL6
    Interactions:

        Search GeneGlobe Interaction Network for TCEAL6

    1 Interacting protein for TCEAL6 (Q6IPX33) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157963I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with TCEAL6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCEAL6 (TCAL6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TCEAL6 gene: 
    NM_001006938.2  

    Unigene Cluster for TCEAL6:

    Transcription elongation factor A (SII)-like 6
    Hs.447815  [show with all ESTs]
    Unigene Representative Sequence: BM925484
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372774(uc004eiq.3) ENST00000372773
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    hsa-miR-3128 hsa-miR-548m hsa-miR-145* hsa-miR-544 hsa-miR-138 hsa-miR-3919 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidTCEAL6 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat TCEAL6

    Additional mRNA sequence: BC071675.1 

    3 DOTS entries:

    DT.40251483  DT.100761954  DT.87046005 

    16 AceView cDNA sequences:

    AI827986 BM693116 BX096480 BC071675 BM668988 AI218907 BM728161 BU728548 
    BX280990 BI753846 BQ068054 AA319193 AA332368 CK003127 BM692144 AW964489 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCEAL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACATTGTA
    TCEAL6 Expression
    About this image

    TCEAL6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCEAL6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.447815
        Custom PCR Arrays for TCEAL6
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TCEAL6 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tceal61 transcription elongation factor A (SII)-like 6 79.26(n)
    69.44(a)
      66104  NM_025355.4  NP_079631.2 


    ENSEMBL Gene Tree for TCEAL6 (if available)
    TreeFam Gene Tree for TCEAL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCEAL6 gene
    TCEAL42  TCEAL32  TCEAL22  TCEAL52  
    7 SIMAP similar genes for TCEAL6 using alignment to 1 protein entry:     TCAL6_HUMAN:
    TCEAL3    TCEAL5    TCEAL4    TCEAL2    TCEAL7    TCEAL8
    WBP5

    Find genes that share paralogs with TCEAL6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCEAL6 (see all 92)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852841321,2
    --101394462(+) TGTACC/TTGGTT 1 -- ds50010--------
    rs1888427331,2
    --101394617(+) AAAAAA/GGGCAT 1 -- ds50010--------
    rs1916492821,2
    --101394636(+) GCAGAC/TATGGA 1 -- ds50010--------
    rs20010451,2
    C,F,O,A,H--101394641(-) ATACTT/GCCATG 1 -- ds500124Minor allele frequency- G:0.68NA EA NS WA CSA 2358
    rs1122151521,2
    C--101394721(+) TCCTCC/TTCCAA 1 -- ds50010--------
    rs1837876321,2
    --101394726(+) CTCCAA/GTGTGT 1 -- ds50010--------
    rs1881802911,2
    --101395027(+) CTTTAC/TTGCCT 1 -- ut310--------
    rs1824492241,2
    --101395041(+) TAAGCA/GCACCA 1 -- ut310--------
    rs1856927981,2
    --101395307(+) ATACAA/GGTGAG 1 -- ut310--------
    rs1999456391,2
    C--101395406(+) ATACA-/ACCATTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TCEAL6 (101394933 - 101397942 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TCEAL6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469670CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCEAL6
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCEAL6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TCEAL6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PubMed id 16221301)1, 3 Winter E.E. and Ponting C.P. (BMC Evol. Biol. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (J. Virol. 2012)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 158931 HGNC: 24553 AceView: LOC158931 Ensembl:ENSG00000204071 euGenes: HUgn158931
    ECgene: TCEAL6 H-InvDB: TCEAL6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCEAL6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCEAL6 gene:
    Search GeneIP for patents involving TCEAL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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