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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCEAL6 Gene

protein-coding   GIFtS: 40
GCID: GC0XM101394

Transcription Elongation Factor A (SII)-Like 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcription Elongation Factor A (SII)-Like 61 2
Transcription Elongation Factor S-II Protein-Like 62 3
TCEA-Like Protein 62 3
Tceal32
Transcription Elongation Factor A (SII)-Like 32
Transcription Elongation Factor A Protein-Like 62

External Ids:    HGNC: 245531   Entrez Gene: 1589312   Ensembl: ENSG000002040717   UniProtKB: Q6IPX33   

Export aliases for TCEAL6 gene to outside databases

Previous GC identifers: GC0XM101202 GC0XM101281 GC0XM091203


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TCEAL6 Gene: 
TCEAL6 (transcription elongation factor A (SII)-like 6) is a protein-coding gene. Diseases associated with TCEAL6 include kaposi's sarcoma, and sarcoma. An important paralog of this gene is TCEAL4.

UniProtKB/Swiss-Prot: TCAL6_HUMAN, Q6IPX3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCEAL6 gene promoter:
         Max1   TBP   USF1   p53   FOXD3   USF2   USF-1:USF-2   FOXL1   MZF-1   USF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TCEAL6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEAL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.1

TCEAL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEAL6 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM101394:  view genomic region     (about GC identifiers)

Start:
101,394,933 bp from pter      End:
101,397,942 bp from pter
Size:
3,010 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCAL6_HUMAN, Q6IPX3 (See protein sequence)
Recommended Name: Transcription elongation factor A protein-like 6  
Size: 200 amino acids; 22298 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q5H9J8
Alternative splicing: 2 isoforms:  Q6IPX3-1   Q6IPX3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TCEAL6: NX_Q6IPX3

Explore proteomics data for TCEAL6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6IPX3

  • TCEAL6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCEAL6 Protein Expression
    REFSEQ proteins: NP_001006939.2  
    ENSEMBL proteins: 
     ENSP00000361860   ENSP00000361859  

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    Cloud-Clone Corp. Proteins for TCEAL6 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TCEAL6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR021156 TF_A-like/BEX-like
     IPR010370 TFA

    Graphical View of Domain Structure for InterPro Entry Q6IPX3

    ProtoNet protein and cluster: Q6IPX3

    UniProtKB/Swiss-Prot: TCAL6_HUMAN, Q6IPX3
    Similarity: Belongs to the TFS-II family. TFA subfamily


    TCEAL6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCAL6_HUMAN, Q6IPX3
    Function: May be involved in transcriptional regulation

    Animal Models:

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TCEAL6 
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    SwitchGear 3'UTR luciferase reporter plasmidTCEAL6 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCEAL6

    1 Interacting protein for TCEAL6 (Q6IPX33) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157963I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    TCEAL6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCEAL6 (TCAL6)

    Search CenterWatch for drugs/clinical trials and news about TCEAL6 / TCAL6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCEAL6 gene: 
    NM_001006938.2  

    Unigene Cluster for TCEAL6:

    Transcription elongation factor A (SII)-like 6
    Hs.447815  [show with all ESTs]
    Unigene Representative Sequence: BM925484
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372774(uc004eiq.3) ENST00000372773
    miRNA
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    hsa-miR-3128 hsa-miR-548m hsa-miR-145* hsa-miR-544 hsa-miR-138 hsa-miR-3919 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidTCEAL6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TCEAL6
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    Additional mRNA sequence: BC071675.1 

    3 DOTS entries:

    DT.40251483  DT.100761954  DT.87046005 

    16 AceView cDNA sequences:

    AI827986 BM693116 BX096480 BU728548 BM668988 BI753846 AA332368 BM728161 
    AA319193 BC071675 AI218907 BX280990 BQ068054 CK003127 BM692144 AW964489 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCEAL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACATTGTA
    TCEAL6 Expression
    About this image


    See TCEAL6 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.447815
        SABiosciences Custom PCR Arrays for TCEAL6
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for TCEAL6 (if available)
    TreeFam Gene Tree for TCEAL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCEAL6 gene
    TCEAL42  TCEAL32  TCEAL22  TCEAL52  
    7 SIMAP similar genes for TCEAL6 using alignment to 1 protein entry:     TCAL6_HUMAN:
    TCEAL3    TCEAL5    TCEAL4    TCEAL2    TCEAL7    TCEAL8
    WBP5

    TCEAL6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/92 SNPs in TCEAL6 are shown (see all 92)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852841321,2
    --101394462(+) TGTACC/TTGGTT 1 -- ds50010--------
    rs1888427331,2
    --101394617(+) AAAAAA/GGGCAT 1 -- ds50010--------
    rs1916492821,2
    --101394636(+) GCAGAC/TATGGA 1 -- ds50010--------
    rs20010451,2
    C,F,O,A,H--101394641(-) ATACTT/GCCATG 1 -- ds500124Minor allele frequency- G:0.68NA EA NS WA CSA 2358
    rs1122151521,2
    C--101394721(+) TCCTCC/TTCCAA 1 -- ds50010--------
    rs1837876321,2
    --101394726(+) CTCCAA/GTGTGT 1 -- ds50010--------
    rs1881802911,2
    --101395027(+) CTTTAC/TTGCCT 1 -- ut310--------
    rs1824492241,2
    --101395041(+) TAAGCA/GCACCA 1 -- ut310--------
    rs1856927981,2
    --101395307(+) ATACAA/GGTGAG 1 -- ut310--------
    rs1999456391,2
    C--101395406(+) ATACA-/ACCATTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TCEAL6 (101394933 - 101397942 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TCEAL6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv469670CNV Complex16826518

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for TCEAL6:    About MalaCards
    kaposi's sarcoma    sarcoma


    TCEAL6 for disorders           About GeneDecksing


    Export disorders for TCEAL6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCEAL6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TCEAL6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere s hortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (2012)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 158931 HGNC: 24553 AceView: LOC158931 Ensembl:ENSG00000204071 euGenes: HUgn158931
    ECgene: TCEAL6 H-InvDB: TCEAL6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCEAL6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCEAL6 gene:
    Search GeneIP for patents involving TCEAL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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