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Aliases for TCEAL6 Gene

Aliases for TCEAL6 Gene

  • Transcription Elongation Factor A Like 6 2 3 5
  • Transcription Elongation Factor S-II Protein-Like 6 3 4
  • Transcription Elongation Factor A (SII)-Like 6 2 3
  • TCEA-Like Protein 6 3 4
  • Transcription Elongation Factor A Protein-Like 6 3
  • Transcription Elongation Factor A (SII)-Like 3 3
  • Tceal3 3
  • WEX2 3

External Ids for TCEAL6 Gene

Previous GeneCards Identifiers for TCEAL6 Gene

  • GC0XM101202
  • GC0XM101281
  • GC0XM101394
  • GC0XM091203

Summaries for TCEAL6 Gene

GeneCards Summary for TCEAL6 Gene

TCEAL6 (Transcription Elongation Factor A Like 6) is a Protein Coding gene. An important paralog of this gene is TCEAL3.

UniProtKB/Swiss-Prot for TCEAL6 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL6 Gene

Genomics for TCEAL6 Gene

Regulatory Elements for TCEAL6 Gene

Enhancers for TCEAL6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF101930 0.9 ENCODE 3.9 +211.3 211294 2.1 ATF1 CBX3 ZNF48 YY1 EGR1 CBX5 CREM EGR2 ZNF362 SP3 BEX5 TCEAL6 ZMAT1 RNU6-345P
GH0XF102141 0.5 Ensembl 0.8 +1.0 970 0.4 ZNF121 POLR2A PRDM10 CHD7 BEX5 LOC105373299 TCEAL6
GH0XF102154 0.6 ENCODE 0.4 -12.7 -12710 1.8 RFX1 ATF1 MTA1 POLR2A SP2 ZNF384 CREM NXF2 NXF2B BEX5 TCEAL6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCEAL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCEAL6 Gene

Chromosome:
X
Start:
102,139,961 bp from pter
End:
102,142,970 bp from pter
Size:
3,010 bases
Orientation:
Minus strand

Genomic View for TCEAL6 Gene

Genes around TCEAL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL6 Gene

Proteins for TCEAL6 Gene

  • Protein details for TCEAL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IPX3-TCAL6_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 6
    Protein Accession:
    Q6IPX3
    Secondary Accessions:
    • Q5H9J8

    Protein attributes for TCEAL6 Gene

    Size:
    200 amino acids
    Molecular mass:
    22298 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCEAL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEAL6 Gene

Post-translational modifications for TCEAL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEAL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCEAL6 Gene

Domains & Families for TCEAL6 Gene

Gene Families for TCEAL6 Gene

Protein Domains for TCEAL6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IPX3

UniProtKB/Swiss-Prot:

TCAL6_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL6: view

Function for TCEAL6 Gene

Molecular function for TCEAL6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for TCEAL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050699 WW domain binding IBA --
genes like me logo Genes that share ontologies with TCEAL6: view

Phenotypes for TCEAL6 Gene

GenomeRNAi human phenotypes for TCEAL6:
genes like me logo Genes that share phenotypes with TCEAL6: view

Animal Model Products

miRNA for TCEAL6 Gene

miRTarBase miRNAs that target TCEAL6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEAL6 Gene

Localization for TCEAL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEAL6 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TCEAL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with TCEAL6: view

Pathways & Interactions for TCEAL6 Gene

SuperPathways for TCEAL6 Gene

No Data Available

Interacting Proteins for TCEAL6 Gene

Selected Interacting proteins: Q6IPX3-TCAL6_HUMAN for TCEAL6 Gene via IID

Symbol External ID(s) Details
SMAD2
UBB

Gene Ontology (GO) - Biological Process for TCEAL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006414 translational elongation IEA --
genes like me logo Genes that share ontologies with TCEAL6: view

No data available for Pathways by source and SIGNOR curated interactions for TCEAL6 Gene

Transcripts for TCEAL6 Gene

mRNA/cDNA for TCEAL6 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCEAL6 Gene

Transcription elongation factor A (SII)-like 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL6 Gene

No ASD Table

Relevant External Links for TCEAL6 Gene

GeneLoc Exon Structure for
TCEAL6
ECgene alternative splicing isoforms for
TCEAL6

Expression for TCEAL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCEAL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCEAL6 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.1), Brain - Cerebellar Hemisphere (x4.9), Brain - Hypothalamus (x4.8), Pituitary (x4.6), Brain - Cortex (x4.6), and Brain - Anterior cingulate cortex (BA24) (x4.4).

Protein differential expression in normal tissues from HIPED for TCEAL6 Gene

This gene is overexpressed in Adrenal (38.4) and Heart (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TCEAL6 Gene



Protein tissue co-expression partners for TCEAL6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCEAL6 Gene:

TCEAL6

SOURCE GeneReport for Unigene cluster for TCEAL6 Gene:

Hs.447815
genes like me logo Genes that share expression patterns with TCEAL6: view

No data available for mRNA Expression by UniProt/SwissProt for TCEAL6 Gene

Orthologs for TCEAL6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL3 34
  • 96.15 (n)
TCEAL6 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tceal6 34 16 35
  • 79.26 (n)
Tceal3 35
  • 62 (a)
ManyToMany
Tceal5 35
  • 60 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 73 (a)
ManyToMany
-- 35
  • 72 (a)
ManyToMany
-- 35
  • 69 (a)
ManyToMany
-- 35
  • 68 (a)
ManyToMany
Species where no ortholog for TCEAL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL6 Gene

ENSEMBL:
Gene Tree for TCEAL6 (if available)
TreeFam:
Gene Tree for TCEAL6 (if available)

Paralogs for TCEAL6 Gene

Paralogs for TCEAL6 Gene

(7) SIMAP similar genes for TCEAL6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCEAL6: view

Variants for TCEAL6 Gene

Sequence variations from dbSNP and Humsavar for TCEAL6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs111588852 -- 102,140,808(+) CCCCT(G/T)GGGCG upstream-variant-2KB, reference, missense
rs111789900 -- 102,141,104(+) GGCTT(C/G/T)CCCTC upstream-variant-2KB, reference, synonymous-codon
rs112215152 -- 102,139,749(+) TCCTC(C/T)TCCAA downstream-variant-500B, upstream-variant-2KB
rs11408120 -- 102,140,809(+) TTGGG(-/A/G)CGAAT upstream-variant-2KB, reference, frameshift-variant
rs12559500 -- 102,141,439(+) GGATA(C/G)TACTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TCEAL6 Gene

Variant ID Type Subtype PubMed ID
nsv1076269 CNV deletion 25765185
nsv469670 CNV loss 16826518

Variation tolerance for TCEAL6 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEAL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEAL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCEAL6 Gene

Disorders for TCEAL6 Gene

Relevant External Links for TCEAL6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEAL6

No disorders were found for TCEAL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL6 Gene

Publications for TCEAL6 Gene

  1. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PMID: 22379092) Shamay M. … Hayward S.D. (J. Virol. 2012) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TCEAL6 Gene

Sources for TCEAL6 Gene

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