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TCEAL5 Gene

protein-coding   GIFtS: 36
GCID: GC0XM102528

Transcription Elongation Factor A (SII)-Like 5

  Search for TCEAL5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Elongation Factor A (SII)-Like 51 2
Transcription Elongation Factor S-II Protein-Like 52 3
TCEA-Like Protein 52 3
WEX42
Transcription Elongation Factor A Protein-Like 52

External Ids:    HGNC: 222821   Entrez Gene: 3405432   Ensembl: ENSG000002040657   UniProtKB: Q5H9L23   

Export aliases for TCEAL5 gene to outside databases

Previous GC identifers: GC0XM102334 GC0XM102415 GC0XM092191


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCEAL5 Gene:
This gene, which is located on the X chromosome, encodes a protein which contains a BEX (brain expressed X-liked
like family) domain. This domain is found in proteins encoded by the TCEAL elongation factor (transcription
elongation factor A (SII)-like) gene family also located on the X chromosome. The coding region for this gene is
located entirely in the terminal exon. (provided by RefSeq, Sep 2011)

GeneCards Summary for TCEAL5 Gene:
TCEAL5 (transcription elongation factor A (SII)-like 5) is a protein-coding gene. An important paralog of this gene is TCEAL4.

UniProtKB/Swiss-Prot: TCAL5_HUMAN, Q5H9L2
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCEAL5 gene promoter:
         SRF   USF1   p53   SRF (504 AA)   Bach2   ATF-2   USF2   USF-1:USF-2   USF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCEAL5 promoter sequence
   Search Chromatin IP Primers for TCEAL5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCEAL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.2

TCEAL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEAL5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM102528:  view genomic region     (about GC identifiers)

Start:
102,528,618 bp from pter      End:
102,531,800 bp from pter
Size:
3,183 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TCAL5_HUMAN, Q5H9L2 (See protein sequence)
Recommended Name: Transcription elongation factor A protein-like 5  
Size: 206 amino acids; 23307 Da
Secondary accessions: A2RUJ4

Explore the universe of human proteins at neXtProt for TCEAL5: NX_Q5H9L2

Explore proteomics data for TCEAL5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TCEAL5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001012997.1  
    ENSEMBL proteins: 
     ENSP00000361765  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021156 TF_A-like/BEX-like
     IPR010370 TFA

    Graphical View of Domain Structure for InterPro Entry Q5H9L2

    ProtoNet protein and cluster: Q5H9L2

    UniProtKB/Swiss-Prot: TCAL5_HUMAN, Q5H9L2
    Similarity: Belongs to the TFS-II family. TFA subfamily


    TCEAL5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCAL5_HUMAN, Q5H9L2
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    TCEAL5 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Tceal5 (no phenotypes)

    TCEAL5 for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidTCEAL5 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCAL5_HUMAN, Q5H9L2: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TCEAL5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCEAL5
    Interactions:

        Search GeneGlobe Interaction Network for TCEAL5

    4 Interacting proteins for TCEAL5 (Q5H9L21, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR4A2P433541, 3EBI-2681773,EBI-2681738 I2D: score=1 
    DEDDO756183I2D: score=1 
    HNF1AP208233I2D: score=1 
    PRKAR1AP106443I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    TCEAL5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCEAL5 (TCAL5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TCEAL5 gene: 
    NM_001012979.2  

    Unigene Cluster for TCEAL5:

    Transcription elongation factor A (SII)-like 5
    Hs.403462  [show with all ESTs]
    Unigene Representative Sequence: NM_001012979
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372680(uc004ejz.2)
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    SwitchGear 3'UTR luciferase reporter plasmidTCEAL5 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat TCEAL5

    Additional mRNA sequence: 

    AF086094.1 BC132922.1 BC132924.1 

    1 DOTS entry:

    DT.91758200 

    19 AceView cDNA sequences:

    CR622925 N64688 BM678026 BX281264 CR596252 AF086094 BI829620 BU738685 
    BQ637865 CB156671 AL526642 AL550633 AI003343 BX355453 BM725918 BM701620 
    BU728483 H40081 H39646 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCEAL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TCEAL5 Expression
    About this image

    TCEAL5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCEAL5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.403462
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TCEAL5 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tceal51 , 5 transcription elongation factor A (SII)-like 51, 5 79.73(n)1
    70.35(a)1
      X (57.40 cM)5
    3315321  NM_177919.21  NP_808587.11 
     1362009485 


    ENSEMBL Gene Tree for TCEAL5 (if available)
    TreeFam Gene Tree for TCEAL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCEAL5 gene
    TCEAL42  TCEAL32  TCEAL62  TCEAL22  
    7 SIMAP similar genes for TCEAL5 using alignment to 1 protein entry:     TCAL5_HUMAN:
    TCEAL3    TCEAL6    TCEAL4    TCEAL2    TCEAL8    WBP5
    TCEAL7

    TCEAL5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCEAL5 (see all 81)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1907226871,2
    --102497596(+) TTAGTG/TCAGGG 1 -- ds50010--------
    rs1819252821,2
    C--102497734(+) AGTAAC/TTGCCA 1 -- ds50010--------
    rs1858933441,2
    --102497792(+) TATCAC/TTTTGT 1 -- ds50010--------
    rs1904494451,2
    --102497831(+) CTTAAC/TATGAT 1 -- ds50010--------
    rs1826937701,2
    --102497921(+) AATAGC/TCTGTG 1 -- ds50010--------
    rs22850851,2
    C,F,H--102498122(-) TGTAAA/CATAAC 1 -- ut316Minor allele frequency- C:0.04NS EA NA 600
    rs1853705361,2
    --102498195(+) TGTAGC/TTGGGT 1 -- ut310--------
    rs3706741471,2
    C--102498300(+) GACTGA/GCAATA 1 -- ut310--------
    rs1421683701,2
    C--102498410(+) CACCCC/GGTTGG 2 P R mis11Minor allele frequency- G:0.00NA 4552
    rs1512114941,2
    F--102498439(+) TCCTGT/CACATC 2 /V syn11Minor allele frequency- C:0.00NA 4552

    HapMap Linkage Disequilibrium report for TCEAL5 (102528618 - 102531800 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TCEAL5: --
    Locus Specific Mutation Databases (LSDB): TCEAL5

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCEAL5
    DNA2.0 Custom Variant and Variant Library Synthesis for TCEAL5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCEAL5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TCEAL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PubMed id 16221301)1, 3 Winter E.E. and Ponting C.P. (BMC Evol. Biol. 2005)
    3. A comprehensive resource of interacting protein regions for refining human transcription factor networks. (PubMed id 20195357)1 Miyamoto-Sato E....Yanagawa H. (PLoS ONE 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 340543 HGNC: 22282 AceView: TCEAL5 Ensembl:ENSG00000204065 euGenes: HUgn340543
    ECgene: TCEAL5 H-InvDB: TCEAL5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCEAL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCEAL5 gene:
    Search GeneIP for patents involving TCEAL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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