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Aliases for TCEAL4 Gene

Aliases for TCEAL4 Gene

  • Transcription Elongation Factor A (SII)-Like 4 2 3
  • Transcription Elongation Factor S-II Protein-Like 4 3 4
  • TCEA-Like Protein 4 3 4
  • Transcription Elongation Factor A Protein-Like 4 3
  • NPD017 3
  • WEX7 3

External Ids for TCEAL4 Gene

Previous GeneCards Identifiers for TCEAL4 Gene

  • GC0XP102637
  • GC0XP102831
  • GC0XP092496

Summaries for TCEAL4 Gene

Entrez Gene Summary for TCEAL4 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. This family is comprised of nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternatively splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 13. [provided by RefSeq, Apr 2015]

GeneCards Summary for TCEAL4 Gene

TCEAL4 (Transcription Elongation Factor A (SII)-Like 4) is a Protein Coding gene. An important paralog of this gene is TCEAL6.

UniProtKB/Swiss-Prot for TCEAL4 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for TCEAL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL4 Gene

Genomics for TCEAL4 Gene

Regulatory Elements for TCEAL4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TCEAL4 Gene

Start:
103,576,231 bp from pter
End:
103,587,736 bp from pter
Size:
11,506 bases
Orientation:
Plus strand

Genomic View for TCEAL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEAL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL4 Gene

Proteins for TCEAL4 Gene

  • Protein details for TCEAL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EI5-TCAL4_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 4
    Protein Accession:
    Q96EI5
    Secondary Accessions:
    • Q8WY12
    • Q9H2H1
    • Q9H775

    Protein attributes for TCEAL4 Gene

    Size:
    215 amino acids
    Molecular mass:
    24647 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCEAL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEAL4 Gene

Proteomics data for TCEAL4 Gene at MOPED

Post-translational modifications for TCEAL4 Gene

  • Ubiquitination at Lys139, Lys142, and Lys175
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TCEAL4 Gene

Domains for TCEAL4 Gene

Protein Domains for TCEAL4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96EI5

UniProtKB/Swiss-Prot:

TCAL4_HUMAN :
  • Q96EI5
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL4: view

No data available for Gene Families for TCEAL4 Gene

Function for TCEAL4 Gene

Molecular function for TCEAL4 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Phenotypes for TCEAL4 Gene

GenomeRNAi human phenotypes for TCEAL4:
genes like me logo Genes that share phenotypes with TCEAL4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TCEAL4 Gene

Localization for TCEAL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEAL4 Gene COMPARTMENTS Subcellular localization image for TCEAL4 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TCEAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCEAL4: view

Pathways for TCEAL4 Gene

SuperPathways for TCEAL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCEAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCEAL4: view

No data available for Pathways by source for TCEAL4 Gene

Transcripts for TCEAL4 Gene

Unigene Clusters for TCEAL4 Gene

Transcription elongation factor A (SII)-like 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCEAL4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3
SP1: - -
SP2: -
SP3: - -
SP4: - - - -
SP5: -

Relevant External Links for TCEAL4 Gene

GeneLoc Exon Structure for
TCEAL4
ECgene alternative splicing isoforms for
TCEAL4

Expression for TCEAL4 Gene

mRNA expression in normal human tissues for TCEAL4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCEAL4 Gene

SOURCE GeneReport for Unigene cluster for TCEAL4 Gene Hs.194329

genes like me logo Genes that share expressions with TCEAL4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TCEAL4 Gene

Orthologs for TCEAL4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL4 35
  • 99.22 (n)
  • 99.07 (a)
TCEAL4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 61 (a)
OneToMany
TCEAL4 35
  • 81.22 (n)
  • 66.2 (a)
dog
(Canis familiaris)
Mammalia TCEAL4 35
  • 77.72 (n)
  • 62.76 (a)
Species with no ortholog for TCEAL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL4 Gene

ENSEMBL:
Gene Tree for TCEAL4 (if available)
TreeFam:
Gene Tree for TCEAL4 (if available)

Paralogs for TCEAL4 Gene

Paralogs for TCEAL4 Gene

Selected SIMAP similar genes for TCEAL4 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for TCEAL4 Gene

genes like me logo Genes that share paralogs with TCEAL4: view

Variants for TCEAL4 Gene

Sequence variations from dbSNP and Humsavar for TCEAL4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs11010 -- 103,587,113(+) ATACA(C/T)GATAT synonymous-codon, reference
rs221930 -- 103,584,915(+) aaggc(C/T)agaaa upstream-variant-2KB, intron-variant
rs221931 -- 103,585,493(+) TCCTG(G/T)GCTGC utr-variant-5-prime, intron-variant, upstream-variant-2KB
rs221933 -- 103,587,239(+) CAGGA(C/T)CCCTT reference, synonymous-codon
rs221943 -- 103,581,112(-) gttta(C/T)gtgca intron-variant

Relevant External Links for TCEAL4 Gene

HapMap Linkage Disequilibrium report
TCEAL4
Locus Specific Mutation Databases (LSDB)
TCEAL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL4 Gene

Disorders for TCEAL4 Gene

(1) University of Copenhagen DISEASES for TCEAL4 Gene

genes like me logo Genes that share disorders with TCEAL4: view

No data available for UniProtKB/Swiss-Prot for TCEAL4 Gene

Publications for TCEAL4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3
  5. Cloning of human B lymphocyte activation-related novel gene. (PMID: 12905813) Lu X.W. … Cui L.X. (Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2001) 3 4

Products for TCEAL4 Gene

Sources for TCEAL4 Gene

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