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TCEAL4 Gene

protein-coding   GIFtS: 48
GCID: GC0XP102831

Transcription Elongation Factor A (SII)-Like 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Elongation Factor A (SII)-Like 41 2
Transcription Elongation Factor S-II Protein-Like 42 3
TCEA-Like Protein 42 3
NPD0172
WEX72
Transcription Elongation Factor A Protein-Like 42

External Ids:    HGNC: 261211   Entrez Gene: 799212   Ensembl: ENSG000001331427   UniProtKB: Q96EI53   

Export aliases for TCEAL4 gene to outside databases

Previous GC identifers: GC0XP102637 GC0XP092496


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCEAL4 Gene:
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of
this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a
promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing
occurs for this gene; however, the full-length nature of all transcript variants has not yet been described.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TCEAL4 Gene:
TCEAL4 (transcription elongation factor A (SII)-like 4) is a protein-coding gene. An important paralog of this gene is TCEAL3.

UniProtKB/Swiss-Prot: TCAL4_HUMAN, Q96EI5
Function: May be involved in transcriptional regulation

Gene Wiki entry for TCEAL4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCEAL4 gene promoter:
         POU2F2 (Oct-2.1)   RFX1   oct-B2   oct-B3   p53   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCEAL4 promoter sequence
   Search Chromatin IP Primers for TCEAL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCEAL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.2   Ensembl cytogenetic band:  Xq22.2   HGNC cytogenetic band: Xq22.2

TCEAL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEAL4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP102831:  view genomic region     (about GC identifiers)

Start:
102,831,159 bp from pter      End:
102,842,657 bp from pter
Size:
11,499 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCAL4_HUMAN, Q96EI5 (See protein sequence)
Recommended Name: Transcription elongation factor A protein-like 4  
Size: 215 amino acids; 24647 Da
Secondary accessions: Q8WY12 Q9H2H1 Q9H775
Alternative splicing: 2 isoforms:  Q96EI5-1   Q96EI5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TCEAL4: NX_Q96EI5

Explore proteomics data for TCEAL4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys139, Lys142, Lys175
  • Modification sites at PhosphoSitePlus

  • See TCEAL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001006936.1  NP_001006938.1  NP_079139.4  

    ENSEMBL proteins: 
     ENSP00000361712   ENSP00000421857   ENSP00000421156   ENSP00000415564   ENSP00000425883  
     ENSP00000423723   ENSP00000424314   ENSP00000427494   ENSP00000411320   ENSP00000394029  
     ENSP00000427053  

    TCEAL4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021156 TF_A-like/BEX-like
     IPR010370 TFA

    Graphical View of Domain Structure for InterPro Entry Q96EI5

    ProtoNet protein and cluster: Q96EI5

    UniProtKB/Swiss-Prot: TCAL4_HUMAN, Q96EI5
    Similarity: Belongs to the TFS-II family. TFA subfamily


    Find genes that share domains with TCEAL4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCAL4_HUMAN, Q96EI5
    Function: May be involved in transcriptional regulation

    Phenotypes:
         1 GenomeRNAi human phenotype for TCEAL4:

     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCEAL4
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    hsa-miR-544 hsa-miR-9* hsa-miR-767-5p hsa-miR-590-3p hsa-miR-501-3p hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidTCEAL4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TCEAL4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCAL4_HUMAN, Q96EI5: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with TCEAL4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCEAL4
    Interactions:

        Search GeneGlobe Interaction Network for TCEAL4

    4 Interacting proteins for TCEAL4 (Q96EI53) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP11P517843I2D: score=3 
    TCEAL1Q151703I2D: score=2 
    TCEAL2Q9H3H93I2D: score=2 
    USP7Q930093I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with TCEAL4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCEAL4 (TCAL4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TCEAL4 gene (4 alternative transcripts): 
    NM_001006935.1  NM_001006937.1  NM_024863.4  NM_001006936.1  

    Unigene Cluster for TCEAL4:

    Transcription elongation factor A (SII)-like 4
    Hs.194329  [show with all ESTs]
    Unigene Representative Sequence: BG114224
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372629 ENST00000468024 ENST00000481555 ENST00000472484(uc004ekl.3 uc004ekm.3 uc004ekn.3)
    ENST00000415568 ENST00000490644 ENST00000459722 ENST00000472745 ENST00000494801
    ENST00000434216 ENST00000425011 ENST00000469586
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate TCEAL4:
    hsa-miR-544 hsa-miR-9* hsa-miR-767-5p hsa-miR-590-3p hsa-miR-501-3p hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidTCEAL4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TCEAL4
    Predesigned siRNA for gene silencing in human, mouse, rat TCEAL4
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    Primer
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    OriGene qPCR primer pairs and template standards for TCEAL4
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      QuantiTect SYBR Green Assays in human, mouse, rat TCEAL4
      QuantiFast Probe-based Assays in human, mouse, rat TCEAL4

    Additional mRNA sequence: 

    AF271783.1 AF314542.1 AK024827.1 AK225117.1 AL833640.1 AY885169.1 BC012296.1 Z36792.1 

    14 DOTS entries:

    DT.317092  DT.95314798  DT.92445818  DT.95178129  DT.95178134  DT.95178132  DT.97855497  DT.100788785 
    DT.92445820  DT.100788783  DT.121297552  DT.100649598  DT.100658886  DT.95178133 

    Selected AceView cDNA sequences (see all 281):

    BQ028546 AI681574 BM989830 BM563679 CB135358 BU782828 AI818323 AA758925 
    AI697638 BU845229 BM686461 W88790 BU786959 AA693392 BF718552 AA622922 
    BQ773375 BM672458 AA432125 BI916149 AI652020 AA149459 BM969000 BG288140 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL4    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3
    SP1:                                -     -                     
    SP2:                                      -                     
    SP3:                                -     -                     
    SP4:                                -     -     -     -         
    SP5:                                -                           


    ECgene alternative splicing isoforms for TCEAL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCEAL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAAATGT
    TCEAL4 Expression
    About this image

    TCEAL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCEAL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.194329
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for TCEAL4 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia TCEAL41 transcription elongation factor A (SII)-like 4 77.72(n)
    62.76(a)
      100682778  XM_005641604.1  XP_005641661.1 


    ENSEMBL Gene Tree for TCEAL4 (if available)
    TreeFam Gene Tree for TCEAL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCEAL4 gene
    TCEAL32  TCEAL62  TCEAL22  TCEAL52  
    5 SIMAP similar genes for TCEAL4 using alignment to 6 protein entries:     TCAL4_HUMAN (see all proteins):
    TCEAL2    TCEAL5    TCEAL3    TCEAL6    WBP5

    Find genes that share paralogs with TCEAL4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TCEAL4
    PGOHUM00000248362


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCEAL4 (see all 70)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1842205411,2
    --102807960(+) GAATGA/GTGAGA 3 -- us2k10--------
    rs1908138611,2
    --102808004(+) AGGGGA/CCTGCT 3 -- us2k10--------
    rs1504278511,2
    --102808172(+) AGTTGA/CAGAAA 3 -- us2k10--------
    rs1820493221,2
    --102808286(+) TGGAGA/TGCAAT 3 -- us2k10--------
    rs1382390741,2
    --102808392(+) CCACGC/TCCAGC 3 -- us2k10--------
    rs1495903431,2
    --102808421(+) TAGAGA/GTGGGG 3 -- us2k10--------
    rs59875461,2
    C,F,A,H--102808532(+) CCTGGA/CCGATA 3 -- us2k14Minor allele frequency- C:0.25NA 8
    rs66216991,2
    C,F,A,H--102808672(+) ATCTAC/TCAGCA 3 -- us2k126Minor allele frequency- N:0.00NS EA NA 2622
    rs1862962811,2
    --102808692(+) TTGTTA/GTACAG 3 -- us2k10--------
    rs1426333401,2
    --102808831(+) CACCAA/CGAAAT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for TCEAL4 (102831159 - 102842657 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TCEAL4: --
    Locus Specific Mutation Databases (LSDB): TCEAL4

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCEAL4
    DNA2.0 Custom Variant and Variant Library Synthesis for TCEAL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for TCEAL4:
    Endometritis

    Find genes that share disorders with TCEAL4           About GenesLikeMe


    Export disorders for TCEAL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCEAL4 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with TCEAL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PubMed id 16221301)1, 3 Winter E.E. and Ponting C.P. (BMC Evol. Biol. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Cloning of human B lymphocyte activation-related novel gene. (PubMed id 12905813)1, 2 Lu X.W.... Cui L.X. (Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2001)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79921 HGNC: 26121 AceView: TCEAL4 Ensembl:ENSG00000133142 euGenes: HUgn79921
    ECgene: TCEAL4 H-InvDB: TCEAL4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCEAL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCEAL4 gene:
    Search GeneIP for patents involving TCEAL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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