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Aliases for TCEAL4 Gene

Aliases for TCEAL4 Gene

  • Transcription Elongation Factor A (SII)-Like 4 2 3
  • Transcription Elongation Factor S-II Protein-Like 4 3 4
  • TCEA-Like Protein 4 3 4
  • NPD017 3
  • WEX7 3

External Ids for TCEAL4 Gene

Previous GeneCards Identifiers for TCEAL4 Gene

  • GC0XP102637
  • GC0XP102831
  • GC0XP092496

Summaries for TCEAL4 Gene

Entrez Gene Summary for TCEAL4 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. This family is comprised of nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternatively splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 13. [provided by RefSeq, Apr 2015]

GeneCards Summary for TCEAL4 Gene

TCEAL4 (Transcription Elongation Factor A (SII)-Like 4) is a Protein Coding gene. Diseases associated with TCEAL4 include acrocallosal syndrome. An important paralog of this gene is TCEAL6.

UniProtKB/Swiss-Prot for TCEAL4 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for TCEAL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL4 Gene

Genomics for TCEAL4 Gene

Regulatory Elements for TCEAL4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TCEAL4 Gene

103,576,231 bp from pter
103,587,736 bp from pter
11,506 bases
Plus strand

Genomic View for TCEAL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEAL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL4 Gene

Proteins for TCEAL4 Gene

  • Protein details for TCEAL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription elongation factor A protein-like 4
    Protein Accession:
    Secondary Accessions:
    • Q8WY12
    • Q9H2H1
    • Q9H775

    Protein attributes for TCEAL4 Gene

    215 amino acids
    Molecular mass:
    24647 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCEAL4 Gene


neXtProt entry for TCEAL4 Gene

Proteomics data for TCEAL4 Gene at MOPED

Post-translational modifications for TCEAL4 Gene

  • Ubiquitination at Lys 139 and Lys 142
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TCEAL4 Gene

Domains & Families for TCEAL4 Gene

Protein Domains for TCEAL4 Gene


Suggested Antigen Peptide Sequences for TCEAL4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TFS-II family. TFA subfamily.
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL4: view

No data available for Gene Families for TCEAL4 Gene

Function for TCEAL4 Gene

Molecular function for TCEAL4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for TCEAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity --
GO:0050699 WW domain binding IBA --
genes like me logo Genes that share ontologies with TCEAL4: view

Phenotypes for TCEAL4 Gene

GenomeRNAi human phenotypes for TCEAL4:
genes like me logo Genes that share phenotypes with TCEAL4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEAL4 Gene

Localization for TCEAL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL4 Gene

Subcellular locations from

Jensen Localization Image for TCEAL4 Gene COMPARTMENTS Subcellular localization image for TCEAL4 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for TCEAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TCEAL4: view

Pathways & Interactions for TCEAL4 Gene

SuperPathways for TCEAL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCEAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006414 translational elongation --
genes like me logo Genes that share ontologies with TCEAL4: view

No data available for Pathways by source and SIGNOR curated interactions for TCEAL4 Gene

Drugs & Compounds for TCEAL4 Gene

No Compound Related Data Available

Transcripts for TCEAL4 Gene

Unigene Clusters for TCEAL4 Gene

Transcription elongation factor A (SII)-like 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCEAL4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3
SP1: - -
SP2: -
SP3: - -
SP4: - - - -
SP5: -

Relevant External Links for TCEAL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCEAL4 Gene

mRNA expression in normal human tissues for TCEAL4 Gene

Protein differential expression in normal tissues from HIPED for TCEAL4 Gene

This gene is overexpressed in Ovary (19.7), Urinary Bladder (6.3), and Fetal testis (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCEAL4 Gene

SOURCE GeneReport for Unigene cluster for TCEAL4 Gene Hs.194329

genes like me logo Genes that share expression patterns with TCEAL4: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TCEAL4 Gene

Orthologs for TCEAL4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TCEAL4 35
  • 81.22 (n)
  • 66.2 (a)
-- 36
  • 61 (a)
(Canis familiaris)
Mammalia TCEAL4 35
  • 77.72 (n)
  • 62.76 (a)
(Pan troglodytes)
Mammalia TCEAL4 35
  • 99.22 (n)
  • 99.07 (a)
  • 99 (a)
Species with no ortholog for TCEAL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL4 Gene

Gene Tree for TCEAL4 (if available)
Gene Tree for TCEAL4 (if available)

Paralogs for TCEAL4 Gene

Paralogs for TCEAL4 Gene

(5) SIMAP similar genes for TCEAL4 Gene using alignment to 6 proteins: Pseudogenes for TCEAL4 Gene

genes like me logo Genes that share paralogs with TCEAL4: view

Variants for TCEAL4 Gene

Sequence variations from dbSNP and Humsavar for TCEAL4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs58036910 -- 103,587,819(+) CTTGT(-/TGT)GAGGA downstream-variant-500B
rs113624873 -- 103,587,818(+) AAATT(C/G)TTGTG downstream-variant-500B
rs147968949 -- 103,588,025(+) TCTCT(C/T)CCCTT downstream-variant-500B
rs184634960 -- 103,587,676(+) TTCTC(A/C)TAAAA utr-variant-3-prime
rs189198389 -- 103,588,101(+) CAGAA(A/G)TAAGT downstream-variant-500B

Variation tolerance for TCEAL4 Gene

Residual Variation Intolerance Score: 47.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEAL4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL4 Gene

Disorders for TCEAL4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCEAL4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acrocallosal syndrome
  • joubert syndrome 12
- elite association

Relevant External Links for TCEAL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TCEAL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCEAL4 Gene

Publications for TCEAL4 Gene

  1. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 67
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  4. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 67
  5. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 67

Products for TCEAL4 Gene

Sources for TCEAL4 Gene

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