TCEAL4 Gene
protein-coding GIFtS: 46
GCID: GC0XP102831
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|
transcription elongation factor A (SII)-like 4
| |
Aliases
for TCEAL4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transcription Elongation Factor A (SII)-Like 41 2 | | Transcription Elongation Factor S-II Protein-Like 42 3 | | TCEA-Like Protein 42 3 | | FLJ211741 | | NPD0172 | | Transcription Elongation Factor A Protein-Like 42 |
Export aliases for TCEAL4 gene to outside databasesPrevious GC identifers: GC0XP102637 GC0XP092496 |
Summaries
for TCEAL4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TCEAL4:
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of thisfamily contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promotercontext-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing occurs forthis gene; however, the full-length nature of all transcript variants has not yet been described. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: TCAL4_HUMAN, Q96EI5Function: May be involved in transcriptional regulation
Gene Wiki entry for TCEAL4
|
Genomic Views
for TCEAL4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TCEAL4 gene promoter:
POU2F2 (Oct-2.1) RFX1 oct-B2 oct-B3 p53 POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCEAL4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEAL4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.2 Ensembl cytogenetic band: Xq22.2 HGNC cytogenetic band: Xq22.2TCEAL4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP102831: view genomic region
(about GC identifiers)
Start:
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102,831,159 bp from pter |
End:
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102,842,657 bp from pter |
Size:
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11,499 bases |
Orientation:
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plus strand |
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Proteins
for TCEAL4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TCAL4_HUMAN, Q96EI5 (See
protein sequence)Recommended Name: Transcription elongation factor A protein-like 4 Size: 215 amino acids; 24647 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q8WY12 Q9H2H1 Q9H775Alternative splicing: 2 isoforms: Q96EI5-1 Q96EI5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TCEAL4: NX_Q96EI5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96EI5
TCEAL4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001006936.1 NP_001006938.1 NP_079139.4
ENSEMBL proteins: ENSP00000361712 ENSP00000421857 ENSP00000421156 ENSP00000415564 ENSP00000425883 ENSP00000423723 ENSP00000424314 ENSP00000427494 ENSP00000411320 ENSP00000394029 ENSP00000427053
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
TCEAL4 for ontologies About GeneDecksing
TCEAL4 Antibody Products:
Assay Products for TCEAL4: |
Protein
Domains /
Families
for TCEAL4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCEAL4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96EI5ProtoNet protein and cluster: Q96EI5 UniProtKB/Swiss-Prot: TCAL4_HUMAN, Q96EI5Similarity: Belongs to the TFS-II family. TFA subfamily |
Function
for TCEAL4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TCAL4_HUMAN, Q96EI5Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCEAL4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEAL4 (see all 4)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL4 |
1 GenomeRNAi human phenotype for TCEAL4:
|
Pathways & Interactions
for TCEAL4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCEAL4
4 Interacting proteins for TCEAL4 (Q96EI53) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
TCEAL4 for ontologies About GeneDecksing
|
Drugs & Compounds
for TCEAL4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TCEAL4
Search CenterWatch for drugs/clinical trials and news about TCEAL4 / TCAL4
|
Transcripts
for TCEAL4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCEAL4 gene (4 alternative transcripts): NM_001006935.1 NM_001006937.1 NM_024863.4 NM_001006936.1 Unigene Cluster for TCEAL4: Transcription elongation factor A (SII)-like 4 Hs.194329 [show with all ESTs]Unigene Representative Sequence: BG11422412 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372629 ENST00000468024 ENST00000481555 ENST00000472484(uc004ekl.3 uc004ekm.3 uc004ekn.3)
ENST00000415568 ENST00000490644 ENST00000459722 ENST00000472745 ENST00000494801
ENST00000434216 ENST00000425011 ENST00000469586
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCEAL4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEAL4 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TCEAL4 (NM_001006935) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCEAL4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEAL4 |
Additional cDNA sequence: AF271783.1 AF314542.1 AK024827.1 AK225117.1 AL833640.1 AY885169.1 BC012296.1 Z36792.1 14 DOTS entries: DT.317092 DT.95314798 DT.92445818 DT.95178129 DT.95178134 DT.95178132 DT.97855497 DT.100788785 DT.92445820 DT.100788783 DT.121297552 DT.100649598 DT.100658886 DT.95178133 24/281 AceView cDNA sequences (see all 281): BM698357 BU682184 AU253367 AI804752 BM669085 N73975 AA676472 AK093021 AA622422 AI681574 AL535343 BU073426 AA454873 AX747862 AA523985 AA445963 AI826333 BQ949973 AI818323 AA758925 CB135358 BU782828 CK430927 BM563679
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL4 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | ^ | 3 |
|---|
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| SP1: | | | | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for TCEAL4
|
Expression
for TCEAL4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCEAL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAAAATGT
About this image
See TCEAL4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCEAL4
SOURCE GeneReport for Unigene cluster: Hs.194329
SABiosciences Custom PCR Arrays for TCEAL4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCEAL4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TCEAL4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCEAL4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEAL4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL4 |
Orthologs
for TCEAL4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for TCEAL4 (if available)
TreeFam Gene Tree for TCEAL4 (if available) |
Paralogs
for TCEAL4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TCEAL4 gene
- TCEAL32 TCEAL62 TCEAL52 TCEAL22
5 SIMAP similar genes for TCEAL4 using alignment to 6 protein entries: TCAL4_HUMAN (see all proteins):TCEAL2 TCEAL5 TCEAL3 TCEAL6 WBP5
TCEAL4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TCEAL4
PGOHUM00000248362
|
Genomic Variants
for TCEAL4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TCEAL4 (102831159 - 102842657 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TCEAL4: --
Locus Specific Mutation Databases (LSDB): TCEAL4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCEAL4 |
|
Disorders
/ Diseases
for TCEAL4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCEAL4 for disorders About GeneDecksing
3  diseases for TCEAL4: About MalaCardsendometritis thyroid cancer thyroiditis
1 disease from the University of Copenhagen DISEASES database for TCEAL4:Endometritis Export disorders for TCEAL4 gene to outside databases
|
Publications
for TCEAL4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCEAL4 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with TCEAL4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning of human B lymphocyte activation-related novel gene. (PubMed id 12905813)1, 2 Lu X.W.... Cui L.X. (2001)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
|
External Searches for TCEAL4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TCEAL4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCEAL4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCEAL4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TCEAL4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TCEAL4 gene:
Search GeneIP for patents involving TCEAL4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCEAL4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for TCEAL4 | | OriGene Custom Protein Services for TCEAL4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCEAL4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCEAL4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEAL4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCEAL4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEAL4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCEAL4 |
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| |  |  |  |  | | | | |
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 | | | TCEAL4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL4 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEAL4 |
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