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Aliases for TCEAL4 Gene

Aliases for TCEAL4 Gene

  • Transcription Elongation Factor A Like 4 2 3 5
  • Transcription Elongation Factor S-II Protein-Like 4 3 4
  • Transcription Elongation Factor A (SII)-Like 4 2 3
  • TCEA-Like Protein 4 3 4
  • Transcription Elongation Factor A Protein-Like 4 3
  • NPD017 3
  • WEX7 3

External Ids for TCEAL4 Gene

Previous GeneCards Identifiers for TCEAL4 Gene

  • GC0XP102637
  • GC0XP102831
  • GC0XP092496

Summaries for TCEAL4 Gene

Entrez Gene Summary for TCEAL4 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. This family is comprised of nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternatively splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 13. [provided by RefSeq, Apr 2015]

GeneCards Summary for TCEAL4 Gene

TCEAL4 (Transcription Elongation Factor A Like 4) is a Protein Coding gene. An important paralog of this gene is TCEAL2.

UniProtKB/Swiss-Prot for TCEAL4 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for TCEAL4 Gene

Additional gene information for TCEAL4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL4 Gene

Genomics for TCEAL4 Gene

GeneHancer (GH) Regulatory Elements for TCEAL4 Gene

Promoters and enhancers for TCEAL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI103584 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 559.9 +9.6 9590 2.5 HDGF USF1 MLX SIN3A YY1 ZNF507 HIC1 ZNF335 ZFHX2 GLIS2 TCEAL4 LOC105373300 TCEAL3 TCEAL1 TCEAL3-AS1 BEX4 ENSG00000279894
GH0XI103151 Enhancer 1.2 Ensembl ENCODE 9.7 -423.9 -423922 1.3 ARNT NEUROD1 FEZF1 GLI4 BRCA1 ZNF2 ZBTB7B TCF12 ZNF121 GLIS2 GPRASP1 BEX4 TCEAL3 ELF2P1 TMSB15B ZCCHC18 GPRASP2 BEX3 TCEAL7 TCEAL1
GH0XI103637 Enhancer 0.7 Ensembl ENCODE 12.1 +62.3 62296 2.2 RFX1 RFX3 MYNN FOSL2 FOS ZIC2 ZBTB17 TCEAL3 TCEAL4 PLP1 BEX4 BEX2 LOC105373302 LOC100130176
GH0XI103396 Enhancer 1.2 FANTOM5 Ensembl ENCODE 3.9 -178.4 -178441 3.5 MEIS2 LEF1 ETV1 JUN ZNF384 CEBPG FOSL1 ZFHX2 ZNF350 TRIM24 BEX4 TCEAL9 TCEAL4 ENSG00000281091 LL0XNC01-250H12.3 BEX3
GH0XI103640 Enhancer 0.3 ENCODE 12.1 +64.3 64307 0.2 NFE2 TCEAL3 TCEAL4 PLP1 LOC105373302 LOC100130176
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCEAL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCEAL4 gene promoter:

Genomic Locations for TCEAL4 Gene

Genomic Locations for TCEAL4 Gene
chrX:103,576,231-103,587,736
(GRCh38/hg38)
Size:
11,506 bases
Orientation:
Plus strand
chrX:102,831,159-102,842,657
(GRCh37/hg19)

Genomic View for TCEAL4 Gene

Genes around TCEAL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL4 Gene

Proteins for TCEAL4 Gene

  • Protein details for TCEAL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EI5-TCAL4_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 4
    Protein Accession:
    Q96EI5
    Secondary Accessions:
    • Q8WY12
    • Q9H2H1
    • Q9H775

    Protein attributes for TCEAL4 Gene

    Size:
    215 amino acids
    Molecular mass:
    24647 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCEAL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEAL4 Gene

Post-translational modifications for TCEAL4 Gene

  • Ubiquitination at isoforms=2139 and posLast=142142

No data available for DME Specific Peptides for TCEAL4 Gene

Domains & Families for TCEAL4 Gene

Gene Families for TCEAL4 Gene

Protein Domains for TCEAL4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96EI5

UniProtKB/Swiss-Prot:

TCAL4_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL4: view

Function for TCEAL4 Gene

Molecular function for TCEAL4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for TCEAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050699 WW domain binding IBA --
genes like me logo Genes that share ontologies with TCEAL4: view

Phenotypes for TCEAL4 Gene

GenomeRNAi human phenotypes for TCEAL4:
genes like me logo Genes that share phenotypes with TCEAL4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEAL4 Gene

Localization for TCEAL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEAL4 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TCEAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TCEAL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCEAL4 Gene

Pathways & Interactions for TCEAL4 Gene

SuperPathways for TCEAL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCEAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0006414 translational elongation IEA --
genes like me logo Genes that share ontologies with TCEAL4: view

No data available for Pathways by source and SIGNOR curated interactions for TCEAL4 Gene

Drugs & Compounds for TCEAL4 Gene

No Compound Related Data Available

Transcripts for TCEAL4 Gene

Unigene Clusters for TCEAL4 Gene

Transcription elongation factor A (SII)-like 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3
SP1: - -
SP2: -
SP3: - -
SP4: - - - -
SP5: -

Relevant External Links for TCEAL4 Gene

GeneLoc Exon Structure for
TCEAL4
ECgene alternative splicing isoforms for
TCEAL4

Expression for TCEAL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCEAL4 Gene

Protein differential expression in normal tissues from HIPED for TCEAL4 Gene

This gene is overexpressed in Ovary (19.7), Urinary Bladder (6.3), and Fetal testis (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCEAL4 Gene



NURSA nuclear receptor signaling pathways regulating expression of TCEAL4 Gene:

TCEAL4

SOURCE GeneReport for Unigene cluster for TCEAL4 Gene:

Hs.194329

Evidence on tissue expression from TISSUES for TCEAL4 Gene

  • Nervous system(4.6)
  • Liver(4.5)
  • Muscle(4.4)
  • Heart(2.7)
  • Spleen(2.5)
  • Kidney(2.4)
  • Lung(2.4)
  • Thyroid gland(2.4)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with TCEAL4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEAL4 Gene

Orthologs for TCEAL4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL4 33 34
  • 99.22 (n)
cow
(Bos Taurus)
Mammalia TCEAL4 33
  • 81.22 (n)
-- 34
  • 61 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TCEAL4 33
  • 77.72 (n)
Species where no ortholog for TCEAL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL4 Gene

ENSEMBL:
Gene Tree for TCEAL4 (if available)
TreeFam:
Gene Tree for TCEAL4 (if available)

Paralogs for TCEAL4 Gene

Paralogs for TCEAL4 Gene

(5) SIMAP similar genes for TCEAL4 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for TCEAL4 Gene

genes like me logo Genes that share paralogs with TCEAL4: view

Variants for TCEAL4 Gene

Sequence variations from dbSNP and Humsavar for TCEAL4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000402403 -- 103,576,961(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000847812 -- 103,586,213(+) C/T 5_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant
rs1000900159 -- 103,586,522(+) T/C intron_variant
rs1001004830 -- 103,581,900(+) T/C genic_upstream_transcript_variant, intron_variant
rs1001164580 -- 103,578,137(+) T/C genic_upstream_transcript_variant, intron_variant

Variation tolerance for TCEAL4 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCEAL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEAL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL4 Gene

Disorders for TCEAL4 Gene

Additional Disease Information for TCEAL4

No disorders were found for TCEAL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL4 Gene

Publications for TCEAL4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter EE … Ponting CP (BMC evolutionary biology 2005) 2 3 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. [Cloning of human B lymphocyte activation-related novel gene]. (PMID: 12905813) Lu XW … Cui LX (Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2001) 3 4 58

Products for TCEAL4 Gene

Sources for TCEAL4 Gene

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