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Aliases for TCEAL3 Gene

Aliases for TCEAL3 Gene

  • Transcription Elongation Factor A (SII)-Like 3 2 3
  • Transcription Elongation Factor S-II Protein-Like 3 3 4
  • TCEA-Like Protein 3 3 4
  • WEX8 3

External Ids for TCEAL3 Gene

Previous GeneCards Identifiers for TCEAL3 Gene

  • GC0XP102668
  • GC0XP102862
  • GC0XP092518

Summaries for TCEAL3 Gene

Entrez Gene Summary for TCEAL3 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEAL3 Gene

TCEAL3 (Transcription Elongation Factor A (SII)-Like 3) is a Protein Coding gene. An important paralog of this gene is TCEAL6.

UniProtKB/Swiss-Prot for TCEAL3 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL3 Gene

Genomics for TCEAL3 Gene

Regulatory Elements for TCEAL3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TCEAL3 Gene

Chromosome:
X
Start:
103,607,451 bp from pter
End:
103,629,690 bp from pter
Size:
22,240 bases
Orientation:
Plus strand

Genomic View for TCEAL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEAL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL3 Gene

Proteins for TCEAL3 Gene

  • Protein details for TCEAL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969E4-TCAL3_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 3
    Protein Accession:
    Q969E4
    Secondary Accessions:
    • D3DXA4

    Protein attributes for TCEAL3 Gene

    Size:
    200 amino acids
    Molecular mass:
    22502 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCEAL3 Gene

Proteomics data for TCEAL3 Gene at MOPED

Post-translational modifications for TCEAL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEAL3 Gene

Antibody Products

No data available for DME Specific Peptides for TCEAL3 Gene

Domains & Families for TCEAL3 Gene

Protein Domains for TCEAL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969E4

UniProtKB/Swiss-Prot:

TCAL3_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL3: view

No data available for Gene Families for TCEAL3 Gene

Function for TCEAL3 Gene

Molecular function for TCEAL3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for TCEAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050699 WW domain binding IBA --
genes like me logo Genes that share ontologies with TCEAL3: view

Phenotypes for TCEAL3 Gene

genes like me logo Genes that share phenotypes with TCEAL3: view

Animal Model Products

miRNA for TCEAL3 Gene

miRTarBase miRNAs that target TCEAL3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCEAL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEAL3 Gene

Localization for TCEAL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEAL3 Gene COMPARTMENTS Subcellular localization image for TCEAL3 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for TCEAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TCEAL3: view

Pathways & Interactions for TCEAL3 Gene

SuperPathways for TCEAL3 Gene

No Data Available

Interacting Proteins for TCEAL3 Gene

Selected Interacting proteins: Q969E4-TCAL3_HUMAN for TCEAL3 Gene via I2D

Symbol External ID(s) Details
ETS1

Gene Ontology (GO) - Biological Process for TCEAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with TCEAL3: view

No data available for Pathways by source and SIGNOR curated interactions for TCEAL3 Gene

Drugs & Compounds for TCEAL3 Gene

No Compound Related Data Available

Transcripts for TCEAL3 Gene

Unigene Clusters for TCEAL3 Gene

Transcription elongation factor A (SII)-like 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCEAL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d
SP1: -
SP2:
SP3:
SP4: -

Relevant External Links for TCEAL3 Gene

GeneLoc Exon Structure for
TCEAL3
ECgene alternative splicing isoforms for
TCEAL3

Expression for TCEAL3 Gene

mRNA expression in normal human tissues for TCEAL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TCEAL3 Gene

This gene is overexpressed in Adrenal (19.6), Uterus (7.4), and Skin (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TCEAL3 Gene



SOURCE GeneReport for Unigene cluster for TCEAL3 Gene Hs.311776

genes like me logo Genes that share expression patterns with TCEAL3: view

Protein tissue co-expression partners for TCEAL3 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TCEAL3 Gene

Orthologs for TCEAL3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL3 35
  • 99.67 (n)
  • 99 (a)
TCEAL3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tceal6 35
  • 79.29 (n)
  • 69.7 (a)
mouse
(Mus musculus)
Mammalia Tceal3 16
Tceal3 36
  • 73 (a)
ManyToMany
Tceal5 36
  • 69 (a)
ManyToMany
Tceal6 36
  • 74 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 77 (a)
ManyToMany
-- 36
  • 83 (a)
ManyToMany
-- 36
  • 77 (a)
ManyToMany
-- 36
  • 85 (a)
ManyToMany
Species with no ortholog for TCEAL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL3 Gene

ENSEMBL:
Gene Tree for TCEAL3 (if available)
TreeFam:
Gene Tree for TCEAL3 (if available)

Paralogs for TCEAL3 Gene

Paralogs for TCEAL3 Gene

(5) SIMAP similar genes for TCEAL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCEAL3: view

Variants for TCEAL3 Gene

Sequence variations from dbSNP and Humsavar for TCEAL3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_059829 -

Variation tolerance for TCEAL3 Gene

Residual Variation Intolerance Score: 52.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEAL3 Gene

HapMap Linkage Disequilibrium report
TCEAL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL3 Gene

Disorders for TCEAL3 Gene

Relevant External Links for TCEAL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEAL3
genes like me logo Genes that share disorders with TCEAL3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL3 Gene

Publications for TCEAL3 Gene

  1. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 67
  2. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67
  3. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PMID: 17525332) Matsuoka S. … Elledge S.J. (Science 2007) 67
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 67
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 67

Products for TCEAL3 Gene

Sources for TCEAL3 Gene

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