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Aliases for TCEAL3 Gene

Aliases for TCEAL3 Gene

  • Transcription Elongation Factor A Like 3 2 3 5
  • Transcription Elongation Factor S-II Protein-Like 3 3 4
  • Transcription Elongation Factor A (SII)-Like 3 2 3
  • TCEA-Like Protein 3 3 4
  • Transcription Elongation Factor A Protein-Like 3 3
  • WEX8 3

External Ids for TCEAL3 Gene

Previous GeneCards Identifiers for TCEAL3 Gene

  • GC0XP102668
  • GC0XP102862
  • GC0XP092518

Summaries for TCEAL3 Gene

Entrez Gene Summary for TCEAL3 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEAL3 Gene

TCEAL3 (Transcription Elongation Factor A Like 3) is a Protein Coding gene. An important paralog of this gene is TCEAL5.

UniProtKB/Swiss-Prot for TCEAL3 Gene

  • May be involved in transcriptional regulation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL3 Gene

Genomics for TCEAL3 Gene

Regulatory Elements for TCEAL3 Gene

Enhancers for TCEAL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG103151 1.2 Ensembl ENCODE 23.2 -455.1 -455143 1.3 ARNT FEZF1 GLI4 BRCA1 ZNF2 ZBTB7B TCF12 ZNF121 GLIS2 FOS GPRASP1 BEX4 TCEAL3 ELF2P1 ZCCHC18 BEX3 TCEAL7 TCEAL1 BHLHB9 ARMCX5-GPRASP2
GH0XG103655 1.1 Ensembl ENCODE 13.2 +50.2 50235 4.2 TBP FOXA2 BRCA1 RFX5 GATA2 ZNF366 RCOR1 FOS EGR2 CEBPB BEX4 MORF4L2-AS1 MORF4L2 TCEAL3 ZCCHC18 TCEAL1 TCEAL3-AS1 BHLHB9 PLP1 FAM199X
GH0XG103584 0.9 ENCODE 13.9 -21.5 -21459 2.2 HDGF PKNOX1 MLX CREB3L1 NFRKB SIN3A YY1 GLIS2 ZNF766 EGR1 TCEAL3 TCEAL1 TCEAL3-AS1 TCEAL4 BEX4 LOC105373300 ENSG00000279894
GH0XG103637 0.8 Ensembl ENCODE 13.6 +31.1 31077 2.2 RFX1 RFX3 MYNN FOS ZIC2 TCEAL3 TCEAL4 PLP1 BEX4 BEX2 LOC105373302 LOC100130176
GH0XG103920 0.7 Ensembl 13.8 +313.5 313450 0.2 ZFP64 ZBTB11 ZNF426 ZNF394 ZNF623 ZNF781 TBX21 ZNF518A ZNF697 ZNF555 TCEAL3 ZCCHC18 BEX3 TCEAL7 RAB9B BEX4 ELF2P1 TCEAL5 LOC100128594 LOC644261
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCEAL3 on UCSC Golden Path with GeneCards custom track

Promoters for TCEAL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247725 294 1601 PKNOX1 RB1 RAD21 YY1 GLIS2 EGR2 ZNF654 SP3 ZEB2 ZNF398

Genomic Location for TCEAL3 Gene

Chromosome:
X
Start:
103,607,451 bp from pter
End:
103,629,690 bp from pter
Size:
22,240 bases
Orientation:
Plus strand

Genomic View for TCEAL3 Gene

Genes around TCEAL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL3 Gene

Proteins for TCEAL3 Gene

  • Protein details for TCEAL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969E4-TCAL3_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 3
    Protein Accession:
    Q969E4
    Secondary Accessions:
    • D3DXA4

    Protein attributes for TCEAL3 Gene

    Size:
    200 amino acids
    Molecular mass:
    22502 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCEAL3 Gene

Post-translational modifications for TCEAL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEAL3 Gene

No data available for DME Specific Peptides for TCEAL3 Gene

Domains & Families for TCEAL3 Gene

Gene Families for TCEAL3 Gene

Protein Domains for TCEAL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969E4

UniProtKB/Swiss-Prot:

TCAL3_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL3: view

Function for TCEAL3 Gene

Molecular function for TCEAL3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for TCEAL3 Gene

genes like me logo Genes that share phenotypes with TCEAL3: view

Animal Model Products

CRISPR Products

miRNA for TCEAL3 Gene

miRTarBase miRNAs that target TCEAL3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEAL3 Gene

Localization for TCEAL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEAL3 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TCEAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCEAL3: view

Pathways & Interactions for TCEAL3 Gene

SuperPathways for TCEAL3 Gene

No Data Available

Interacting Proteins for TCEAL3 Gene

Selected Interacting proteins: Q969E4-TCAL3_HUMAN for TCEAL3 Gene via IID

Gene Ontology (GO) - Biological Process for TCEAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCEAL3: view

No data available for Pathways by source and SIGNOR curated interactions for TCEAL3 Gene

Drugs & Compounds for TCEAL3 Gene

No Compound Related Data Available

Transcripts for TCEAL3 Gene

Unigene Clusters for TCEAL3 Gene

Transcription elongation factor A (SII)-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d
SP1: -
SP2:
SP3:
SP4: -

Relevant External Links for TCEAL3 Gene

GeneLoc Exon Structure for
TCEAL3
ECgene alternative splicing isoforms for
TCEAL3

Expression for TCEAL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCEAL3 Gene

Protein differential expression in normal tissues from HIPED for TCEAL3 Gene

This gene is overexpressed in Adrenal (19.6), Uterus (7.4), and Skin (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TCEAL3 Gene



Protein tissue co-expression partners for TCEAL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCEAL3 Gene:

TCEAL3

SOURCE GeneReport for Unigene cluster for TCEAL3 Gene:

Hs.311776

Evidence on tissue expression from TISSUES for TCEAL3 Gene

  • Eye(4.3)
  • Skin(4.2)
  • Stomach(4.2)
  • Nervous system(2.6)
  • Heart(2.3)
  • Spleen(2.3)
  • Kidney(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with TCEAL3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEAL3 Gene

Orthologs for TCEAL3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL3 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 85 (a)
ManyToMany
-- 35
  • 83 (a)
ManyToMany
-- 35
  • 77 (a)
ManyToMany
-- 35
  • 77 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tceal6 34
  • 79.29 (n)
mouse
(Mus musculus)
Mammalia Tceal6 35
  • 74 (a)
ManyToMany
Tceal3 35
  • 73 (a)
ManyToMany
Tceal5 35
  • 69 (a)
ManyToMany
Species where no ortholog for TCEAL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL3 Gene

ENSEMBL:
Gene Tree for TCEAL3 (if available)
TreeFam:
Gene Tree for TCEAL3 (if available)

Paralogs for TCEAL3 Gene

Paralogs for TCEAL3 Gene

(5) SIMAP similar genes for TCEAL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCEAL3: view

Variants for TCEAL3 Gene

Sequence variations from dbSNP and Humsavar for TCEAL3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000217403 -- 103,606,100(+) TAGTG(A/G)CCTAC intron-variant, upstream-variant-2KB
rs1001408916 -- 103,606,646(+) ATATA(C/T)GAAAT intron-variant, upstream-variant-2KB
rs1002526248 -- 103,608,639(+) GGCCT(A/C)AAAAG intron-variant, utr-variant-5-prime
rs1003079255 -- 103,609,118(+) AAGCC(A/G)GAAGA intron-variant, reference, synonymous-codon
rs1005537597 -- 103,606,711(+) AGAAT(A/T)AAAAG intron-variant, upstream-variant-2KB

Variation tolerance for TCEAL3 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEAL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEAL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL3 Gene

Disorders for TCEAL3 Gene

Relevant External Links for TCEAL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEAL3

No disorders were found for TCEAL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL3 Gene

Publications for TCEAL3 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3 64
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TCEAL3 Gene

Sources for TCEAL3 Gene

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