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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TCEAL3 Gene

protein-coding GIFtS: 44
GCID: GC0XP102862

transcription elongation factor A (SII)-like 3

Search for TCEAL3
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transcription Elongation Factor A (SII)-Like 3¹ ²
Transcription Elongation Factor S-II Protein-Like 3² ³
TCEA-Like Protein 3² ³
MGC15737¹
Transcription Elongation Factor A Protein-Like 3²

External Ids:	HGNC: 28247¹	Entrez Gene: 85012²	Ensembl: ENSG00000196507⁷	UniProtKB: Q969E4³

Export aliases for TCEAL3 gene to outside databases

Previous GC identifers: GC0XP102668 GC0XP092518

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCEAL3:

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this

family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter

context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in

multiple transcript variants encoding a single isoform. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TCAL3_HUMAN, Q969E4

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011651.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TCEAL3 gene promoter:
c-Fos p53 AP-1 XBP-1 RORalpha2 CREB deltaCREB Cart-1 c-Jun ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TCEAL3 promoter sequence

Search SABiosciences Chromatin IP Primers for TCEAL3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEAL3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.2 Ensembl cytogenetic band: Xq22.2 HGNC cytogenetic band: Xq22.2

TCEAL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEAL3 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP102862: view genomic region (about GC identifiers)

Start:	102,862,379 bp from pter	End:	102,884,618 bp from pter
Size:	22,240 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TCAL3_HUMAN, Q969E4 (See protein sequence)

Recommended Name: Transcription elongation factor A protein-like 3

Size: 200 amino acids; 22502 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: D3DXA4

Explore the universe of human proteins at neXtProt for TCEAL3: NX_Q969E4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q969E4

TCEAL3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001006934.1 NP_116315.1

ENSEMBL proteins:

ENSP00000361711 ENSP00000361710 ENSP00000243286

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

TCEAL3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TCEAL3 for domains About GeneDecksing

2 InterPro domains/families:

IPR021156 TF_A-like/BEX-like

IPR010370 TFA

Graphical View of Domain Structure for InterPro Entry Q969E4

ProtoNet protein and cluster: Q969E4

UniProtKB/Swiss-Prot: TCAL3_HUMAN, Q969E4

Similarity: Belongs to the TFS-II family. TFA subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TCAL3_HUMAN, Q969E4

Function: May be involved in transcriptional regulation

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1 GenomeRNAi human phenotype for TCEAL3:

Increased cell number in G2M,

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TCEAL3

1 Interacting protein for TCEAL3 (Q969E4³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ETS1	P14921³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

TCEAL3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TCEAL3
Search CenterWatch for drugs/clinical trials and news about TCEAL3 / TCAL3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for TCEAL3 gene (2 alternative transcripts):

NM_001006933.1 NM_032926.2

Unigene Cluster for TCEAL3:

Transcription elongation factor A (SII)-like 3

Hs.311776 [show with all ESTs]

Unigene Representative Sequence: BM546671

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000372628 ENST00000372627(uc004ekr.3) ENST00000477014 ENST00000243286(uc004ekq.3)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEAL3

Additional cDNA sequence:

AF163263.1 AK098494.1 BC007622.1 BC008703.1

1 DOTS entry:

DT.87046005

24/182 AceView cDNA sequences (see all 182):

BU617176 BX283384 CR602449 CA502741 CB160805 AI269131 AA993786 BC008703

BQ014180 AW263944 CD251121 AI498256 N22292 BM666502 BU676815 BG760935

BC007622 BM984303 BE350778 AW518587 AW157800 BM708086 AW161297 AI097048

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL3 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3a	·	3b	·	3c	·	3d
SP1:									-
SP2:
SP3:
SP4:									-

ECgene alternative splicing isoforms for TCEAL3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TCEAL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTACATTGTA

About this image

TCEAL3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Bone

Limb

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TCEAL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCEAL3

SOURCE GeneReport for Unigene cluster: Hs.311776

SABiosciences Custom PCR Arrays for TCEAL3

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TCEAL3 gene from 1/3 species (see all 3) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tceal3⁵ Tceal6¹	transcription elongation factor A (SII)-like 3⁵ transcription elongation factor A (SII)-like 6¹	81.82(n)¹ 75.25(a)¹		X (59.10 cM)⁵ 66104¹ NM_025355.4¹ NP_079631.2¹ 136590842⁵

ENSEMBL Gene Tree for TCEAL3 (if available)
TreeFam Gene Tree for TCEAL3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TCEAL3 gene

TCEAL4² TCEAL6² TCEAL5² TCEAL2²

5 SIMAP similar genes for TCEAL3 using alignment to 1 protein entry: TCAL3_HUMAN:

TCEAL6 TCEAL5 TCEAL4 TCEAL2 WBP5

TCEAL3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185832353^1,2		--	102860882(+)	`AGGCAC/TATTTC`	2	--	us2k¹		0	--	--	--	--
rs3813783^1,2	C	--	102860906(-)	`TCTGAA/CTTTTG`	2	--	us2k¹		1		NA	2
rs190157997^1,2		--	102861153(+)	`GACCAA/GGAGTG`	2	--	us2k¹		0	--	--	--	--
rs137886708^1,2		--	102861193(+)	`AGAGTA/GGAGAT`	2	--	us2k¹		0	--	--	--	--
rs149470796^1,2		--	102861243(+)	`GTCAAC/GATTAC`	2	--	us2k¹		0	--	--	--	--
rs144384953^1,2		--	102861285(+)	`TGATTC/TCCAGA`	2	--	us2k¹		0	--	--	--	--
rs182753563^1,2		--	102861619(+)	`AGCAAA/GCAGAC`	2	--	us2k¹		0	--	--	--	--
rs186043866^1,2		--	102861701(+)	`TATCTC/GAAATC`	2	--	us2k¹		0	--	--	--	--
rs7892745^1,2	C,F,H,	--	102862129(+)	`AAAGAT/CATTTA`	2	--	us2k¹		8		NS NA WA CSA	793
rs142250809^1,2		--	102862142(+)	`TTGTCC/TTTAAA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TCEAL3 (102862379 - 102884618 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TCEAL3: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TCEAL3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TCEAL3)

Utopia: connect your pdf to the dynamic
world of online information

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)² Matsuoka S.... Elledge S.J. (2007)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)
Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR. (PubMed id 10051408)¹ Pillutla R.C.... Shatkin A.J. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 85012	HGNC: 28247	AceView: TCEAL1andTCEAL3	Ensembl:ENSG00000196507	euGenes: HUgn85012
ECgene: TCEAL3	H-InvDB: TCEAL3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TCEAL3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TCEAL3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TCEAL3 gene:
Search GeneIP for patents involving TCEAL3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCEAL3
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	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEAL3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCEAL3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCEAL3
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	GenScript Custom Purified and Recombinant Proteins Services for TCEAL3		GenScript cDNA clones with any tag delivered in your preferred vector for TCEAL3
	GenScript Custom Assay Services for TCEAL3		GenScript Custom Superior Antibodies Services for TCEAL3
	GenScript Custom overexpressing Cell Line Services for TCEAL3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in TCEAL3 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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	Search for Antibodies for TCEAL3 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for TCEAL3
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Recombinant Protein for TCEAL3

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Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TCEAL3

	SwitchGear 3'UTR luciferase reporter plasmids for TCEAL3
	SwitchGear Promoter luciferase reporter plasmids for TCEAL3

ThermoFisher Antibodies for TCEAL3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEAL3

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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TCEAL3 Gene

transcription elongation factor A (SII)-like 3

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TCEAL3 Gene

transcription elongation factor A (SII)-like 3

Aliasesfor TCEAL3 gene

Summariesfor TCEAL3 gene

Genomic Viewsfor TCEAL3 gene

Proteinsfor TCEAL3 gene

Protein Domains /Familiesfor TCEAL3 gene

Functionfor TCEAL3 gene

Pathways & Interactionsfor TCEAL3 gene

Drugs & Compoundsfor TCEAL3 gene

Transcriptsfor TCEAL3 gene

Expression for TCEAL3 gene

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Disorders / Diseasesfor TCEAL3 gene

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External Searches for TCEAL3 gene

Genome Databases showing TCEAL3 gene

Other Databases showing TCEAL3 gene

Specialized Databases showing TCEAL3 gene

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Aliases
for TCEAL3 gene

Summaries
for TCEAL3 gene

Genomic Views
for TCEAL3 gene

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for TCEAL3 gene

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Families
for TCEAL3 gene

Function
for TCEAL3 gene

Pathways & Interactions
for TCEAL3 gene

Drugs & Compounds
for TCEAL3 gene

Transcripts
for TCEAL3 gene

Expression
for TCEAL3 gene

Orthologs
for TCEAL3 gene

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Genomic Variants
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Disorders / Diseases
for TCEAL3 gene

Publications
for TCEAL3 gene

Intellectual Property
for TCEAL3 gene

Products
for TCEAL3 gene