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Aliases for TCEAL2 Gene

Aliases for TCEAL2 Gene

  • Transcription Elongation Factor A Like 2 2 3 5
  • Transcription Elongation Factor S-II Protein-Like 2 3 4
  • Transcription Elongation Factor A (SII)-Like 2 2 3
  • TCEA-Like Protein 2 3 4
  • Transcription Elongation Factor A Protein-Like 2 3
  • MY0876G05 3
  • My048 3
  • WEX1 3

External Ids for TCEAL2 Gene

Previous GeneCards Identifiers for TCEAL2 Gene

  • GC0XP101186
  • GC0XP101267
  • GC0XP101380
  • GC0XP091188

Summaries for TCEAL2 Gene

Entrez Gene Summary for TCEAL2 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEAL2 Gene

TCEAL2 (Transcription Elongation Factor A Like 2) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway. An important paralog of this gene is TCEAL4.

UniProtKB/Swiss-Prot for TCEAL2 Gene

  • May be involved in transcriptional regulation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL2 Gene

Genomics for TCEAL2 Gene

Regulatory Elements for TCEAL2 Gene

Enhancers for TCEAL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG103063 0.8 ENCODE 11.1 +938.1 938129 1.6 CTCF TFAP4 ZBTB21 ZIC2 HIC1 GLIS2 POLR2A PATZ1 PRDM10 ZBTB20 BEX4 BEX1 GPRASP1 ARMCX5-GPRASP2 BHLHB9 TCEAL2 TCEAL5 GC0XP103022
GH0XG102958 0.6 ENCODE 6.4 +833.9 833909 1.7 CTCF RAD51 MAX USF2 REST RAD21 BEX4 TCEAL2 ENSG00000234050 GC0XM102944
GH0XG102125 0.2 Ensembl 0.7 +0.3 313 0.4 TCEAL2 GC0XM102141
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCEAL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCEAL2 Gene

Chromosome:
X
Start:
102,125,688 bp from pter
End:
102,127,712 bp from pter
Size:
2,025 bases
Orientation:
Plus strand

Genomic View for TCEAL2 Gene

Genes around TCEAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL2 Gene

Proteins for TCEAL2 Gene

  • Protein details for TCEAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3H9-TCAL2_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 2
    Protein Accession:
    Q9H3H9
    Secondary Accessions:
    • B2R5C7

    Protein attributes for TCEAL2 Gene

    Size:
    227 amino acids
    Molecular mass:
    25850 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCEAL2 Gene

Post-translational modifications for TCEAL2 Gene

  • Ubiquitination at isoforms=154
  • Modification sites at PhosphoSitePlus

Other Protein References for TCEAL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCEAL2 Gene

Domains & Families for TCEAL2 Gene

Gene Families for TCEAL2 Gene

Protein Domains for TCEAL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H3H9

UniProtKB/Swiss-Prot:

TCAL2_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL2: view

Function for TCEAL2 Gene

Molecular function for TCEAL2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with TCEAL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCEAL2 Gene

Localization for TCEAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEAL2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TCEAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCEAL2: view

Pathways & Interactions for TCEAL2 Gene

SuperPathways for TCEAL2 Gene

SuperPathway Contained pathways
1 Mesodermal Commitment Pathway
genes like me logo Genes that share pathways with TCEAL2: view

Pathways by source for TCEAL2 Gene

1 BioSystems pathway for TCEAL2 Gene

Gene Ontology (GO) - Biological Process for TCEAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCEAL2: view

No data available for SIGNOR curated interactions for TCEAL2 Gene

Drugs & Compounds for TCEAL2 Gene

No Compound Related Data Available

Transcripts for TCEAL2 Gene

mRNA/cDNA for TCEAL2 Gene

Unigene Clusters for TCEAL2 Gene

Transcription elongation factor A (SII)-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL2 Gene

No ASD Table

Relevant External Links for TCEAL2 Gene

GeneLoc Exon Structure for
TCEAL2
ECgene alternative splicing isoforms for
TCEAL2

Expression for TCEAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCEAL2 Gene

Protein differential expression in normal tissues from HIPED for TCEAL2 Gene

This gene is overexpressed in Bone (28.1), Fetal Brain (13.1), Ovary (11.2), Retina (6.4), and Frontal cortex (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCEAL2 Gene



Protein tissue co-expression partners for TCEAL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCEAL2 Gene:

TCEAL2

SOURCE GeneReport for Unigene cluster for TCEAL2 Gene:

Hs.401835

Evidence on tissue expression from TISSUES for TCEAL2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TCEAL2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEAL2 Gene

Orthologs for TCEAL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL2 34 35
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 59 (a)
OneToMany
Species where no ortholog for TCEAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL2 Gene

ENSEMBL:
Gene Tree for TCEAL2 (if available)
TreeFam:
Gene Tree for TCEAL2 (if available)

Paralogs for TCEAL2 Gene

Paralogs for TCEAL2 Gene

(4) SIMAP similar genes for TCEAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCEAL2: view

Variants for TCEAL2 Gene

Sequence variations from dbSNP and Humsavar for TCEAL2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1002652533 -- 102,123,699(+) GTGTG(C/T)CTCTG upstream-variant-2KB
rs1002947265 -- 102,123,855(+) AGTGG(A/T)TGACA upstream-variant-2KB
rs1003859511 -- 102,128,128(+) GATAA(C/G)GTAGA downstream-variant-500B
rs1004756457 -- 102,127,132(+) GGCAG(A/G)GGGTG reference, missense
rs1009060999 -- 102,125,668(+) CCCGC(A/G)CCCGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TCEAL2 Gene

Variant ID Type Subtype PubMed ID
nsv469670 CNV loss 16826518

Variation tolerance for TCEAL2 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCEAL2 Gene

Disorders for TCEAL2 Gene

Relevant External Links for TCEAL2

Genetic Association Database (GAD)
TCEAL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEAL2

No disorders were found for TCEAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL2 Gene

Publications for TCEAL2 Gene

  1. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. (PMID: 28218735) Kamran M. … Liu Q. (Oncogenesis 2017) 3 64
  5. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3 64

Products for TCEAL2 Gene

Sources for TCEAL2 Gene

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