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TCEAL2 Gene

protein-coding   GIFtS: 50
GCID: GC0XP101380

Transcription Elongation Factor A (SII)-Like 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transcription Elongation Factor A (SII)-Like 21 2     WEX12
Transcription Elongation Factor S-II Protein-Like 22 3     my0482
TCEA-Like Protein 22 3     Transcription Elongation Factor A Protein-Like 22
MY0876G052     

External Ids:    HGNC: 298181   Entrez Gene: 1405972   Ensembl: ENSG000001849057   UniProtKB: Q9H3H93   
ORGUL members:         

Export aliases for TCEAL2 gene to outside databases

Previous GC identifers: GC0XP101186 GC0XP101267 GC0XP091188


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCEAL2 Gene:
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of
this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a
promoter context-dependent manner. Multiple family members are located on the X chromosome. (provided by RefSeq,
Jul 2008)

GeneCards Summary for TCEAL2 Gene:
TCEAL2 (transcription elongation factor A (SII)-like 2) is a protein-coding gene. An important paralog of this gene is TCEAL4.

UniProtKB/Swiss-Prot: TCAL2_HUMAN, Q9H3H9
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCEAL2 gene promoter:
         Max1   USF1   RFX1   HTF   RORalpha2   Max   CREB   deltaCREB   USF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCEAL2 promoter sequence
   Search Chromatin IP Primers for TCEAL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCEAL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1-q22.3   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.1-q22.3

TCEAL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEAL2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP101380:  view genomic region     (about GC identifiers)

Start:
101,380,660 bp from pter      End:
101,382,684 bp from pter
Size:
2,025 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCAL2_HUMAN, Q9H3H9 (See protein sequence)
Recommended Name: Transcription elongation factor A protein-like 2  
Size: 227 amino acids; 25850 Da
Secondary accessions: B2R5C7

Explore the universe of human proteins at neXtProt for TCEAL2: NX_Q9H3H9

Explore proteomics data for TCEAL2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys154, Lys187
  • Modification sites at PhosphoSitePlus

  • See TCEAL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_525129.1  
    ENSEMBL proteins: 
     ENSP00000332359   ENSP00000361866  

    TCEAL2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021156 TF_A-like/BEX-like
     IPR010370 TFA

    Graphical View of Domain Structure for InterPro Entry Q9H3H9

    ProtoNet protein and cluster: Q9H3H9

    UniProtKB/Swiss-Prot: TCAL2_HUMAN, Q9H3H9
    Similarity: Belongs to the TFS-II family. TFA subfamily


    Find genes that share domains with TCEAL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCAL2_HUMAN, Q9H3H9
    Function: May be involved in transcriptional regulation

    Phenotypes:
         2 GenomeRNAi human phenotypes for TCEAL2:

     Decreased Hepatitis C virus re  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCEAL2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCAL2_HUMAN, Q9H3H9: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with TCEAL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCEAL2
    Interactions:

        Search GeneGlobe Interaction Network for TCEAL2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for TCEAL2 (Q9H3H93 ENSP000003323594) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCEAL1Q151703, ENSP000003617074I2D: score=2 STRING: ENSP00000361707
    USP11P517843, ENSP000002183484I2D: score=2 STRING: ENSP00000218348
    SQSTM1Q135013I2D: score=2 
    TCEAL4Q96EI53I2D: score=2 
    NELFBQ8WX923I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with TCEAL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCEAL2 (TCAL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TCEAL2 gene: 
    NM_080390.3  

    Unigene Cluster for TCEAL2:

    Transcription elongation factor A (SII)-like 2
    Hs.401835  [show with all ESTs]
    Unigene Representative Sequence: NM_080390
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476749 ENST00000329035 ENST00000372780(uc004eip.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TCEAL2
      QuantiFast Probe-based Assays in human, mouse, rat TCEAL2

    Additional mRNA sequence: 

    AF325115.1 AK312138.1 BC093932.1 BC104764.1 

    3 DOTS entries:

    DT.95244465  DT.87005682  DT.95289573 

    Selected AceView cDNA sequences (see all 34):

    NM_080390 AA865722 AA642609 AF325115 AA666368 BU948554 CR601113 BE350800 
    BM699243 BU948799 BM311842 BM544332 AL539596 CB269867 CB117724 AL540086 
    BF950746 AA502479 CD580311 AI933920 BF951471 CK003682 AL567939 AA319451 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCEAL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCGTGGAA
    TCEAL2 Expression
    About this image


    TCEAL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 4D20.8, NCr-fac Progenitor
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Bone (Muscoskeletal System)
             TGFbeta3+BMP7-induced chondrocytes
     
     Gonad
             XY Germ Cells Testis Cord
     
     Mesoderm (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
    TCEAL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCEAL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.401835
        Custom PCR Arrays for TCEAL2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for TCEAL2 gene from Selected species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    cow
    (Bos taurus)
    Mammalia --
    Uncharacterized protein
    59(a)
    1 → many
    X(57664213-57664899)


    ENSEMBL Gene Tree for TCEAL2 (if available)
    TreeFam Gene Tree for TCEAL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCEAL2 gene
    TCEAL42  TCEAL32  TCEAL62  TCEAL52  
    4 SIMAP similar genes for TCEAL2 using alignment to 1 protein entry:     TCAL2_HUMAN:
    TCEAL4    TCEAL5    TCEAL3    TCEAL6

    Find genes that share paralogs with TCEAL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCEAL2 (see all 95)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3765694291,2
    C--101346267(+) CCTTT-/TGTG  
            
    GTGTG
    1 -- us2k10--------
    rs105474501,2
    C--101346270(+) CTTTT-/TGTG  
            
    TGTGT
    1 -- us2k10--------
    rs1477596691,2
    C--101346318(+) AGTGTA/TAATAT 1 -- us2k10--------
    rs1931814361,2
    --101346319(+) GTGTTA/TATATA 1 -- us2k10--------
    rs1845151971,2
    --101346327(+) ATATGC/TCTATA 1 -- us2k10--------
    rs1888284341,2
    --101346749(+) GACAGC/TTTAAA 1 -- us2k10--------
    rs802623351,2
    C--101346758(+) AAATCA/TCTATA 1 -- us2k10--------
    rs1916367661,2
    --101346888(+) GCCTCA/GATAAT 1 -- us2k10--------
    rs1837767091,2
    --101346989(+) AAGATC/GAAGGT 1 -- us2k10--------
    rs2012843781,2
    --101347009(+) TGAAG-/AAAGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TCEAL2 (101380660 - 101382684 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TCEAL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469670CNV Complex16826518

    Locus Specific Mutation Databases (LSDB): TCEAL2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCEAL2
    DNA2.0 Custom Variant and Variant Library Synthesis for TCEAL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TCEAL2           About GenesLikeMe

    Genetic Association Database (GAD): TCEAL2

    Export disorders for TCEAL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCEAL2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with TCEAL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PubMed id 16221301)1, 3 Winter E.E. and Ponting C.P. (BMC Evol. Biol. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140597 HGNC: 29818 AceView: TCEAL2 Ensembl:ENSG00000184905 euGenes: HUgn140597
    ECgene: TCEAL2 H-InvDB: TCEAL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCEAL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCEAL2 gene:
    Search GeneIP for patents involving TCEAL2

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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