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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TCEAL2 Gene

protein-coding GIFtS: 45
GCID: GC0XP101380

transcription elongation factor A (SII)-like 2

Search for TCEAL2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transcription Elongation Factor A (SII)-Like 2¹ ²
MY0876G05¹ ²
My048¹
Transcription Elongation Factor S-II Protein-Like 2² ³
TCEA-Like Protein 2² ³
Transcription Elongation Factor A Protein-Like 2²

External Ids:	HGNC: 29818¹	Entrez Gene: 140597²	Ensembl: ENSG00000184905⁷	UniProtKB: Q9H3H9³

Export aliases for TCEAL2 gene to outside databases

Previous GC identifers: GC0XP101186 GC0XP101267 GC0XP091188

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCEAL2:

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this

family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter

context-dependent manner. Multiple family members are located on the X chromosome. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TCAL2_HUMAN, Q9H3H9

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011651.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TCEAL2 gene promoter:
Max1 USF1 RFX1 HTF RORalpha2 Max CREB deltaCREB USF-1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TCEAL2 promoter sequence

Search SABiosciences Chromatin IP Primers for TCEAL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEAL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1-q22.3 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22.1-q22.3

TCEAL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEAL2 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP101380: view genomic region (about GC identifiers)

Start:	101,380,660 bp from pter	End:	101,382,684 bp from pter
Size:	2,025 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TCAL2_HUMAN, Q9H3H9 (See protein sequence)

Recommended Name: Transcription elongation factor A protein-like 2

Size: 227 amino acids; 25850 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: B2R5C7

Explore the universe of human proteins at neXtProt for TCEAL2: NX_Q9H3H9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H3H9

TCEAL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_525129.1

ENSEMBL proteins:

ENSP00000332359 ENSP00000361866

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	Uscn Proteins for TCEAL2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

TCEAL2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TCEAL2 for domains About GeneDecksing

2 InterPro domains/families:

IPR021156 TF_A-like/BEX-like

IPR010370 TFA

Graphical View of Domain Structure for InterPro Entry Q9H3H9

ProtoNet protein and cluster: Q9H3H9

UniProtKB/Swiss-Prot: TCAL2_HUMAN, Q9H3H9

Similarity: Belongs to the TFS-II family. TFA subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TCAL2_HUMAN, Q9H3H9

Function: May be involved in transcriptional regulation

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In Situ Assay
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2 GenomeRNAi human phenotypes for TCEAL2:

Decreased Hepatitis C virus re

Increased HPV18 LCR reporter a

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TCEAL2

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5/9 Interacting proteins for TCEAL2 (Q9H3H9³ ENSP00000332359⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TCEAL1	Q15170³, ENSP00000361707⁴	I2D: score=2 STRING: ENSP00000361707
USP11	P51784³, ENSP00000218348⁴	I2D: score=2 STRING: ENSP00000218348
SQSTM1	Q13501³	I2D: score=2
TCEAL4	Q96EI5³	I2D: score=2
NELFB	Q8WX92³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

TCEAL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TCEAL2
Search CenterWatch for drugs/clinical trials and news about TCEAL2 / TCAL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TCEAL2 gene:

NM_080390.3

Unigene Cluster for TCEAL2:

Transcription elongation factor A (SII)-like 2

Hs.401835 [show with all ESTs]

Unigene Representative Sequence: NM_080390

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000476749 ENST00000329035 ENST00000372780(uc004eip.3)

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Additional cDNA sequence:

AF325115.1 AK312138.1 BC093932.1 BC104764.1

3 DOTS entries:

DT.95244465 DT.87005682 DT.95289573

24/34 AceView cDNA sequences (see all 34):

AA642609 BM699243 AA666368 AA865722 AF325115 BU948554 BE350800 CR601113

NM_080390 BM544332 AL539596 BU948799 CB269867 BM311842 BF951471 AA502479

CK003682 BF950746 AI933920 AL540086 CB117724 CD580311 AA319451 AL567939

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TCEAL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTCGTGGAA

About this image

TCEAL2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TCEAL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCEAL2

SOURCE GeneReport for Unigene cluster: Hs.401835

SABiosciences Custom PCR Arrays for TCEAL2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for TCEAL2 (if available)
TreeFam Gene Tree for TCEAL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TCEAL2 gene

TCEAL3² TCEAL4² TCEAL6² TCEAL5²

4 SIMAP similar genes for TCEAL2 using alignment to 1 protein entry: TCAL2_HUMAN:

TCEAL4 TCEAL5 TCEAL3 TCEAL6

TCEAL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10547450^1,2	C	--	101378661(+)	`CTTTT-/TGTG TGTGT`	1	--	us2k¹		0	--	--	--	--
rs147759669^1,2		--	101378712(+)	`AGTGTA/TAATAT`	1	--	us2k¹		0	--	--	--	--
rs193181436^1,2		--	101378713(+)	`GTGTTA/TATATA`	1	--	us2k¹		0	--	--	--	--
rs184515197^1,2		--	101378721(+)	`ATATGC/TCTATA`	1	--	us2k¹		0	--	--	--	--
rs188828434^1,2		--	101379143(+)	`GACAGC/TTTAAA`	1	--	us2k¹		0	--	--	--	--
rs80262335^1,2	C	--	101379152(+)	`AAATCA/TCTATA`	1	--	us2k¹		0	--	--	--	--
rs191636766^1,2		--	101379282(+)	`GCCTCA/GATAAT`	1	--	us2k¹		0	--	--	--	--
rs183776709^1,2		--	101379383(+)	`AAGATC/GAAGGT`	1	--	us2k¹		0	--	--	--	--
rs201284378^1,2		--	101379403(+)	`TGAAG-/AAAGAT`	1	--	us2k¹		0	--	--	--	--
rs189356589^1,2		--	101379541(+)	`TACATA/TTGTAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TCEAL2 (101380660 - 101382684 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TCEAL2
2 CNVs: 96859 83654
Locus Specific Mutation Databases (LSDB): TCEAL2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TCEAL2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with TCEAL2)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)¹ Persaud A....Rotin D. (2009)
Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)¹ Sowa M.E....Harper J.W. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 140597	HGNC: 29818	AceView: TCEAL2	Ensembl:ENSG00000184905	euGenes: HUgn140597
ECgene: TCEAL2	H-InvDB: TCEAL2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TCEAL2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TCEAL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TCEAL2 gene:
Search GeneIP for patents involving TCEAL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEAL2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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TCEAL2 Gene

transcription elongation factor A (SII)-like 2

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TCEAL2 Gene

transcription elongation factor A (SII)-like 2

Aliasesfor TCEAL2 gene

Summariesfor TCEAL2 gene

Genomic Viewsfor TCEAL2 gene

Proteinsfor TCEAL2 gene

Protein Domains /Familiesfor TCEAL2 gene

Functionfor TCEAL2 gene

Pathways & Interactionsfor TCEAL2 gene

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Expression for TCEAL2 gene

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External Searches for TCEAL2 gene

Genome Databases showing TCEAL2 gene

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Specialized Databases showing TCEAL2 gene

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for TCEAL2 gene

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for TCEAL2 gene

Genomic Views
for TCEAL2 gene

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for TCEAL2 gene

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for TCEAL2 gene

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for TCEAL2 gene

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for TCEAL2 gene

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for TCEAL2 gene

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Expression
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for TCEAL2 gene

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