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Aliases for TCEAL2 Gene

Aliases for TCEAL2 Gene

  • Transcription Elongation Factor A (SII)-Like 2 2 3
  • Transcription Elongation Factor S-II Protein-Like 2 3 4
  • TCEA-Like Protein 2 3 4
  • Transcription Elongation Factor A Protein-Like 2 3
  • MY0876G05 3
  • My048 3
  • WEX1 3

External Ids for TCEAL2 Gene

Previous GeneCards Identifiers for TCEAL2 Gene

  • GC0XP101186
  • GC0XP101267
  • GC0XP101380
  • GC0XP091188

Summaries for TCEAL2 Gene

Entrez Gene Summary for TCEAL2 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEAL2 Gene

TCEAL2 (Transcription Elongation Factor A (SII)-Like 2) is a Protein Coding gene. An important paralog of this gene is TCEAL6.

UniProtKB/Swiss-Prot for TCEAL2 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL2 Gene

Genomics for TCEAL2 Gene

Regulatory Elements for TCEAL2 Gene

Genomic Location for TCEAL2 Gene

Start:
102,125,688 bp from pter
End:
102,127,712 bp from pter
Size:
2,025 bases
Orientation:
Plus strand

Genomic View for TCEAL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL2 Gene

Proteins for TCEAL2 Gene

  • Protein details for TCEAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3H9-TCAL2_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 2
    Protein Accession:
    Q9H3H9
    Secondary Accessions:
    • B2R5C7

    Protein attributes for TCEAL2 Gene

    Size:
    227 amino acids
    Molecular mass:
    25850 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCEAL2 Gene

Proteomics data for TCEAL2 Gene at MOPED

Post-translational modifications for TCEAL2 Gene

  • Ubiquitination at Lys154 and Lys187
  • Modification sites at PhosphoSitePlus

Other Protein References for TCEAL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCEAL2 Gene

Domains for TCEAL2 Gene

Protein Domains for TCEAL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H3H9

UniProtKB/Swiss-Prot:

TCAL2_HUMAN :
  • Q9H3H9
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL2: view

No data available for Gene Families for TCEAL2 Gene

Function for TCEAL2 Gene

Molecular function for TCEAL2 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Phenotypes for TCEAL2 Gene

genes like me logo Genes that share phenotypes with TCEAL2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCEAL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TCEAL2 Gene

Localization for TCEAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEAL2 Gene COMPARTMENTS Subcellular localization image for TCEAL2 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TCEAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCEAL2: view

Pathways for TCEAL2 Gene

SuperPathways for TCEAL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCEAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCEAL2: view

No data available for Pathways by source for TCEAL2 Gene

Transcripts for TCEAL2 Gene

mRNA/cDNA for TCEAL2 Gene

Unigene Clusters for TCEAL2 Gene

Transcription elongation factor A (SII)-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCEAL2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL2 Gene

No ASD Table

Relevant External Links for TCEAL2 Gene

GeneLoc Exon Structure for
TCEAL2
ECgene alternative splicing isoforms for
TCEAL2

Expression for TCEAL2 Gene

mRNA expression in normal human tissues for TCEAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCEAL2 Gene

SOURCE GeneReport for Unigene cluster for TCEAL2 Gene Hs.401835

genes like me logo Genes that share expressions with TCEAL2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TCEAL2 Gene

Orthologs for TCEAL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL2 35
  • 99.41 (n)
  • 98.68 (a)
TCEAL2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 59 (a)
OneToMany
Species with no ortholog for TCEAL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL2 Gene

ENSEMBL:
Gene Tree for TCEAL2 (if available)
TreeFam:
Gene Tree for TCEAL2 (if available)

Paralogs for TCEAL2 Gene

Paralogs for TCEAL2 Gene

Selected SIMAP similar genes for TCEAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCEAL2: view

Variants for TCEAL2 Gene

Sequence variations from dbSNP and Humsavar for TCEAL2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2281290 -- 102,126,346(+) AGCCC(C/T)TGCCC intron-variant
rs5944856 - 102,127,033(+) tgcgg(C/G)aaagg missense, reference
rs5944857 -- 102,127,439(+) TTCTA(C/T)CCTAG synonymous-codon, reference
rs5944858 -- 102,127,445(+) CCTAG(A/G)GGTCC synonymous-codon, reference
rs5945028 -- 102,124,958(+) GAGAG(A/G)CCAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TCEAL2 Gene

Variant ID Type Subtype PubMed ID
nsv469670 CNV Complex 16826518

Relevant External Links for TCEAL2 Gene

HapMap Linkage Disequilibrium report
TCEAL2
Locus Specific Mutation Databases (LSDB)
TCEAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCEAL2 Gene

Disorders for TCEAL2 Gene

Relevant External Links for TCEAL2

Genetic Association Database (GAD)
TCEAL2
genes like me logo Genes that share disorders with TCEAL2: view

No data available for UniProtKB/Swiss-Prot for TCEAL2 Gene

Publications for TCEAL2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  3. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  5. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PMID: 19953087) Persaud A. … Rotin D. (Mol. Syst. Biol. 2009) 3

Products for TCEAL2 Gene

Sources for TCEAL2 Gene

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