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Aliases for TCEAL1 Gene

Aliases for TCEAL1 Gene

  • Transcription Elongation Factor A (SII)-Like 1 2 3
  • SIIR 3 4 6
  • Transcription Elongation Factor S-II Protein-Like 1 3 4
  • Nuclear Phosphoprotein P21/SIIR 3 4
  • TCEA-Like Protein 1 3 4
  • P21 3 6
  • Transcription Elongation Factor A Protein-Like 1 3
  • WEX9 3
  • Pp21 3

External Ids for TCEAL1 Gene

Previous GeneCards Identifiers for TCEAL1 Gene

  • GC0XP098185
  • GC0XP099792
  • GC0XP100916
  • GC0XP101655
  • GC0XP102690
  • GC0XP102770
  • GC0XP102883
  • GC0XP092540

Summaries for TCEAL1 Gene

Entrez Gene Summary for TCEAL1 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEAL1 Gene

TCEAL1 (Transcription Elongation Factor A (SII)-Like 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is WBP5.

UniProtKB/Swiss-Prot for TCEAL1 Gene

  • May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly

Gene Wiki entry for TCEAL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL1 Gene

Genomics for TCEAL1 Gene

Regulatory Elements for TCEAL1 Gene

Genomic Location for TCEAL1 Gene

Start:
103,628,704 bp from pter
End:
103,630,953 bp from pter
Size:
2,250 bases
Orientation:
Plus strand

Genomic View for TCEAL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL1 Gene

Proteins for TCEAL1 Gene

  • Protein details for TCEAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15170-TCAL1_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 1
    Protein Accession:
    Q15170
    Secondary Accessions:
    • Q9UJQ9

    Protein attributes for TCEAL1 Gene

    Size:
    157 amino acids
    Molecular mass:
    18354 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCEAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEAL1 Gene

Proteomics data for TCEAL1 Gene at MOPED

Post-translational modifications for TCEAL1 Gene

  • Phosphorylation of Ser-36 and Ser-37 is critical for transcriptional repression.
  • Ubiquitination at Lys136
  • Modification sites at PhosphoSitePlus

Other Protein References for TCEAL1 Gene

Antibody Products

No data available for DME Specific Peptides for TCEAL1 Gene

Domains for TCEAL1 Gene

Protein Domains for TCEAL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15170

UniProtKB/Swiss-Prot:

TCAL1_HUMAN :
  • Q15170
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL1: view

No data available for Gene Families for TCEAL1 Gene

Function for TCEAL1 Gene

Molecular function for TCEAL1 Gene

GENATLAS Biochemistry: transcription elongation factor A-like 1,widely expressed,modulating transcription in a promoter context-dependent fashion
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly

Gene Ontology (GO) - Molecular Function for TCEAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 7971997
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TCEAL1: view
genes like me logo Genes that share phenotypes with TCEAL1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TCEAL1 Gene

Localization for TCEAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEAL1 Gene COMPARTMENTS Subcellular localization image for TCEAL1 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for TCEAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7971997
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TCEAL1: view

Pathways for TCEAL1 Gene

SuperPathways for TCEAL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCEAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 7971997
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCEAL1: view

No data available for Pathways by source for TCEAL1 Gene

Compounds for TCEAL1 Gene

(5) Novoseek inferred chemical compound relationships for TCEAL1 Gene

Compound -log(P) Hits PubMed IDs
gdp 70 5
gtp 53.2 4
guanine 48.4 1
hydrogen 16.3 3
tyrosine 14.1 2
genes like me logo Genes that share compounds with TCEAL1: view

Transcripts for TCEAL1 Gene

Unigene Clusters for TCEAL1 Gene

Transcription elongation factor A (SII)-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCEAL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -
SP6:

Relevant External Links for TCEAL1 Gene

GeneLoc Exon Structure for
TCEAL1
ECgene alternative splicing isoforms for
TCEAL1

Expression for TCEAL1 Gene

mRNA expression in normal human tissues for TCEAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCEAL1 Gene

SOURCE GeneReport for Unigene cluster for TCEAL1 Gene Hs.95243

mRNA Expression by UniProt/SwissProt for TCEAL1 Gene

Q15170-TCAL1_HUMAN
Tissue specificity: Expressed in all tissues examined. Highly expressed in heart, ovary, prostate and skeletal muscle. Moderately expressed in brain, placenta, testis and small intestine. Weakly expressed in lung, liver and spleen. Expressed in several cancer cell lines.
genes like me logo Genes that share expressions with TCEAL1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TCEAL1 Gene

Orthologs for TCEAL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL1 35
  • 99.79 (n)
  • 100 (a)
TCEAL1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCEAL1 35
  • 84.28 (n)
  • 86.16 (a)
TCEAL1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCEAL1 35
  • 88.89 (n)
  • 89.94 (a)
TCEAL1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tceal1 35
  • 74.63 (n)
  • 74.84 (a)
Tceal1 16
Tceal1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tceal1 35
  • 74.21 (n)
  • 71.7 (a)
Species with no ortholog for TCEAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL1 Gene

ENSEMBL:
Gene Tree for TCEAL1 (if available)
TreeFam:
Gene Tree for TCEAL1 (if available)

Paralogs for TCEAL1 Gene

Paralogs for TCEAL1 Gene

Selected SIMAP similar genes for TCEAL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCEAL1: view

Variants for TCEAL1 Gene

Sequence variations from dbSNP and Humsavar for TCEAL1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs15098 -- 103,630,743(+) ATAGA(C/T)TTCAA utr-variant-3-prime
rs1052145 -- 103,630,116(+) GGAGC(G/T)CCCTC reference, missense
rs1052146 -- 103,630,158(+) TGAGG(G/T)GCGCC reference, missense
rs1052147 -- 103,630,159(+) GAGGG(G/T)CGCCC reference, synonymous-codon
rs1052148 -- 103,630,204(+) CATAA(C/G)CTTGA missense, reference

Relevant External Links for TCEAL1 Gene

HapMap Linkage Disequilibrium report
TCEAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL1 Gene

Disorders for TCEAL1 Gene

Relevant External Links for TCEAL1

Genetic Association Database (GAD)
TCEAL1
Human Genome Epidemiology (HuGE) Navigator
TCEAL1
genes like me logo Genes that share disorders with TCEAL1: view

No data available for UniProtKB/Swiss-Prot for TCEAL1 Gene

Publications for TCEAL1 Gene

  1. A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII. (PMID: 8206389) Yeh C.-H. … Shatkin A.J. (Gene 1994) 2 3 4 23
  2. Polymorphisms in codon 31 of p21 and cervical cancer susceptibility in Korean women. (PMID: 11248419) Roh J. … Lee H. (Cancer Lett. 2001) 3 48
  3. A polymorphism at codon 31 of gene p21 is not associated with primary open angle glaucoma in Caucasians. (PMID: 15807891) Ressiniotis T. … Birch M. (BMC Ophthalmol 2005) 3 48
  4. Lack of evidence that proline homozygosity at codon 72 of p53 and rare arginine allele at codon 31 of p21, jointly mediate cervical cancer susceptibility among Indian women. (PMID: 16054204) Bhattacharya P. … Sengupta S. (Gynecol. Oncol. 2005) 3 48
  5. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3

Products for TCEAL1 Gene

Sources for TCEAL1 Gene

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