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Aliases for TCEAL1 Gene

Aliases for TCEAL1 Gene

  • Transcription Elongation Factor A Like 1 2 3 5
  • Transcription Elongation Factor S-II Protein-Like 1 3 4
  • Transcription Elongation Factor A (SII)-Like 1 2 3
  • Nuclear Phosphoprotein P21/SIIR 3 4
  • TCEA-Like Protein 1 3 4
  • SIIR 3 4
  • Transcription Elongation Factor A Protein-Like 1 3
  • WEX9 3
  • Pp21 3
  • P21 3

External Ids for TCEAL1 Gene

Previous GeneCards Identifiers for TCEAL1 Gene

  • GC0XP098185
  • GC0XP099792
  • GC0XP100916
  • GC0XP101655
  • GC0XP102690
  • GC0XP102770
  • GC0XP102883
  • GC0XP092540

Summaries for TCEAL1 Gene

Entrez Gene Summary for TCEAL1 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEAL1 Gene

TCEAL1 (Transcription Elongation Factor A Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is TCEAL9.

UniProtKB/Swiss-Prot for TCEAL1 Gene

  • May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.

Gene Wiki entry for TCEAL1 Gene

Additional gene information for TCEAL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL1 Gene

Genomics for TCEAL1 Gene

GeneHancer (GH) Regulatory Elements for TCEAL1 Gene

Promoters and enhancers for TCEAL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI103628 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.8 758 2.5 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 IRF4 YY1 GLIS2 ZNF213 LOC105373302 TCEAL1 GC0XM103625 BEX4 TCEAL3
GH0XI103584 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 12.8 -42.9 -42883 2.5 HDGF USF1 MLX SIN3A YY1 ZNF507 HIC1 ZNF335 ZFHX2 GLIS2 TCEAL4 LOC105373300 TCEAL3 TCEAL1 TCEAL3-AS1 BEX4 ENSG00000279894
GH0XI103151 Enhancer 1.2 Ensembl ENCODE 12.8 -476.4 -476395 1.3 ARNT NEUROD1 FEZF1 GLI4 BRCA1 ZNF2 ZBTB7B TCF12 ZNF121 GLIS2 GPRASP1 BEX4 TCEAL3 ELF2P1 TMSB15B ZCCHC18 GPRASP2 BEX3 TCEAL7 TCEAL1
GH0XI103655 Enhancer 1 Ensembl ENCODE 12.6 +29.0 28982 4.2 NCOA3 SOX13 FOXA2 JUN MAX BRCA1 RFX5 ZFHX2 CTBP1 GATA3 MORF4L2-AS1 MORF4L2 TCEAL3 TCEAL1 TCEAL3-AS1 PLP1 BEX4 BEX2 RAB40A LOC100130176
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCEAL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCEAL1 gene promoter:

Genomic Locations for TCEAL1 Gene

Genomic Locations for TCEAL1 Gene
chrX:103,628,704-103,630,953
(GRCh38/hg38)
Size:
2,250 bases
Orientation:
Plus strand
chrX:102,883,632-102,885,881
(GRCh37/hg19)

Genomic View for TCEAL1 Gene

Genes around TCEAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL1 Gene

Proteins for TCEAL1 Gene

  • Protein details for TCEAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15170-TCAL1_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 1
    Protein Accession:
    Q15170
    Secondary Accessions:
    • Q9UJQ9

    Protein attributes for TCEAL1 Gene

    Size:
    157 amino acids
    Molecular mass:
    18354 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCEAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEAL1 Gene

Post-translational modifications for TCEAL1 Gene

  • Phosphorylation of Ser-36 and Ser-37 is critical for transcriptional repression.
  • Ubiquitination at isoforms=2136

Other Protein References for TCEAL1 Gene

No data available for DME Specific Peptides for TCEAL1 Gene

Domains & Families for TCEAL1 Gene

Gene Families for TCEAL1 Gene

Protein Domains for TCEAL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15170

UniProtKB/Swiss-Prot:

TCAL1_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL1: view

Function for TCEAL1 Gene

Molecular function for TCEAL1 Gene

GENATLAS Biochemistry:
transcription elongation factor A-like 1,widely expressed,modulating transcription in a promoter context-dependent fashion
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.

Gene Ontology (GO) - Molecular Function for TCEAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity NAS 7971997
GO:0050699 WW domain binding IBA --
genes like me logo Genes that share ontologies with TCEAL1: view
genes like me logo Genes that share phenotypes with TCEAL1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEAL1 Gene

Localization for TCEAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEAL1 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TCEAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7971997
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TCEAL1: view

Pathways & Interactions for TCEAL1 Gene

SuperPathways for TCEAL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCEAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 7971997
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCEAL1: view

No data available for Pathways by source and SIGNOR curated interactions for TCEAL1 Gene

Drugs & Compounds for TCEAL1 Gene

(2) Drugs for TCEAL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for TCEAL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TCEAL1: view

Transcripts for TCEAL1 Gene

Unigene Clusters for TCEAL1 Gene

Transcription elongation factor A (SII)-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -
SP6:

Relevant External Links for TCEAL1 Gene

GeneLoc Exon Structure for
TCEAL1
ECgene alternative splicing isoforms for
TCEAL1

Expression for TCEAL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCEAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TCEAL1 Gene

This gene is overexpressed in Urinary Bladder (16.3), Ovary (13.1), Prostate (11.1), Testis (8.2), and Blymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCEAL1 Gene



Protein tissue co-expression partners for TCEAL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCEAL1 Gene:

TCEAL1

SOURCE GeneReport for Unigene cluster for TCEAL1 Gene:

Hs.95243

mRNA Expression by UniProt/SwissProt for TCEAL1 Gene:

Q15170-TCAL1_HUMAN
Tissue specificity: Expressed in all tissues examined. Highly expressed in heart, ovary, prostate and skeletal muscle. Moderately expressed in brain, placenta, testis and small intestine. Weakly expressed in lung, liver and spleen. Expressed in several cancer cell lines.
genes like me logo Genes that share expression patterns with TCEAL1: view

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEAL1 Gene

Orthologs for TCEAL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL1 33 34
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia TCEAL1 33 34
  • 88.89 (n)
cow
(Bos Taurus)
Mammalia TCEAL1 33 34
  • 84.28 (n)
mouse
(Mus musculus)
Mammalia Tceal1 33 16 34
  • 74.63 (n)
rat
(Rattus norvegicus)
Mammalia Tceal1 33
  • 74.21 (n)
Species where no ortholog for TCEAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL1 Gene

ENSEMBL:
Gene Tree for TCEAL1 (if available)
TreeFam:
Gene Tree for TCEAL1 (if available)

Paralogs for TCEAL1 Gene

Paralogs for TCEAL1 Gene

(3) SIMAP similar genes for TCEAL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCEAL1: view

Variants for TCEAL1 Gene

Sequence variations from dbSNP and Humsavar for TCEAL1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000381677 -- 103,629,003(+) G/A 5_prime_UTR_variant, intron_variant
rs1001168590 -- 103,628,633(+) G/C upstream_transcript_variant
rs1002096700 -- 103,629,431(+) GTCAGTCAGTC/GTCAGTC intron_variant
rs1004502622 -- 103,630,819(+) TTTTTT/TTTTT 3_prime_UTR_variant
rs1004787430 -- 103,628,216(+) A/G upstream_transcript_variant

Variation tolerance for TCEAL1 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCEAL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL1 Gene

Disorders for TCEAL1 Gene

Additional Disease Information for TCEAL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TCEAL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL1 Gene

Publications for TCEAL1 Gene

  1. A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII. (PMID: 8206389) Yeh CH … Shatkin AJ (Gene 1994) 2 3 4 22 58
  2. Polymorphisms in cell cycle regulatory genes, urinary arsenic profile and urothelial carcinoma. (PMID: 18640142) Chung CJ … Hsueh YM (Toxicology and applied pharmacology 2008) 3 44 58
  3. Polymorphisms of p53 and p21 genes in chronic obstructive pulmonary disease. (PMID: 16697770) Lee YL … Wang YC (The Journal of laboratory and clinical medicine 2006) 3 44 58
  4. Linking TP53 codon 72 and P21 nt590 genotypes to the development of cervical and ovarian cancer. (PMID: 16542834) Santos AM … Medeiros R (European journal of cancer (Oxford, England : 1990) 2006) 3 44 58
  5. TP53 and P21 polymorphisms: response to cisplatinum/paclitaxel-based chemotherapy in ovarian cancer. (PMID: 16364249) Santos AM … Medeiros R (Biochemical and biophysical research communications 2006) 3 44 58

Products for TCEAL1 Gene

Sources for TCEAL1 Gene

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