TCEAL1 Gene
protein-coding GIFtS: 53
GCID: GC0XP102883
|
|
transcription elongation factor A (SII)-like 1
| |
Aliases
for TCEAL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transcription Elongation Factor A (SII)-Like 11 2 | | Transcription Elongation Factor S-II Protein-Like 12 3 | | SIIR1 2 3 5 | | TCEA-Like Protein 12 3 | | P211 5 | | P211 5 | | Pp211 | | Transcription Elongation Factor A Protein-Like 12 | | Nuclear Phosphoprotein P21/SIIR2 3 | | |
Export aliases for TCEAL1 gene to outside databasesPrevious GC identifers: GC0XP098185 GC0XP099792 GC0XP100916 GC0XP101655 GC0XP102690 GC0XP102770 GC0XP092540 |
Summaries
for TCEAL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TCEAL1:
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of thisfamily may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Theencoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zincfinger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exertits effects via protein-protein interactions with other transcriptional regulators rather than via direct binding ofDNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcriptvariants encoding a single isoform. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TCAL1_HUMAN, Q15170Function: May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promotercontext-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus(RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly
Gene Wiki entry for TCEAL1
|
Genomic Views
for TCEAL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TCEAL1 gene promoter:
p53 GATA-3 FOXD3 POU6F1 (c2) ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCEAL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEAL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.1 Ensembl cytogenetic band: Xq22.2 HGNC cytogenetic band: Xq22.1TCEAL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP102883: view genomic region
(about GC identifiers)
Start:
|
102,883,632 bp from pter |
End:
|
102,885,881 bp from pter |
Size:
|
2,250 bases |
Orientation:
|
plus strand |
|
Proteins
for TCEAL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TCAL1_HUMAN, Q15170 (See
protein sequence)Recommended Name: Transcription elongation factor A protein-like 1 Size: 157 amino acids; 18354 Da
Subcellular location: Nucleus
Secondary accessions: Q9UJQ9Alternative splicing: 2 isoforms: Q15170-1 Q15170-2 (Contains a phosphoserine at position 28)Explore the universe of human proteins at neXtProt for TCEAL1: NX_Q15170
Post-translational modifications:
Phosphorylation of Ser-36 and Ser-37 is critical for transcriptional repression1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15170
TCEAL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001006640.1 NP_001006641.1 NP_004771.2
ENSEMBL proteins: ENSP00000361709 ENSP00000361708 ENSP00000361707
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
TCEAL1 for ontologies About GeneDecksing
TCEAL1 Antibody Products:
Assay Products for TCEAL1: |
Protein
Domains /
Families
for TCEAL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCEAL1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15170ProtoNet protein and cluster: Q15170 UniProtKB/Swiss-Prot: TCAL1_HUMAN, Q15170Similarity: Belongs to the TFS-II family. TFA subfamily |
Function
for TCEAL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TCAL1_HUMAN, Q15170Function: May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promotercontext-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus(RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly Genatlas biochemistry entry for TCEAL1:transcription elongation factor A-like 1,widely expressed,modulating transcription in a promoter context-dependentfashion
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
NAS | 7971997 | | GO:0005515 | protein binding |
-- | -- |
TCEAL1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TCEAL1:
|
Pathways & Interactions
for TCEAL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCEAL1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/34 Interacting proteins for TCEAL1 (Q151703 ENSP000003617074) via UniProtKB, MINT, STRING, and/or I2D (see all 34)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
TAS | 7971997 | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- |
TCEAL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TCEAL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TCEAL1 for compounds About GeneDecksing
 Browse Tocris compounds for TCEAL1
5 Novoseek chemical compound relationships for TCEAL1 gene About this table
Search CenterWatch for drugs/clinical trials and news about TCEAL1 / TCAL1
|
Transcripts
for TCEAL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCEAL1 gene (3 alternative transcripts): NM_001006639.1 NM_001006640.1 NM_004780.2 Unigene Cluster for TCEAL1: Transcription elongation factor A (SII)-like 1 Hs.95243 [show with all ESTs]Unigene Representative Sequence: NM_0047804 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372626 ENST00000372625(uc004ekt.3 uc004eku.3) ENST00000469820
ENST00000372624(uc004eks.3)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEAL1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Synthesis Service for TCEAL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEAL1 |
Additional cDNA sequence: BC000809.1 M99701.1 6 DOTS entries: DT.115566 DT.100025362 DT.91720648 DT.121301124 DT.121301122 DT.40213593 24/182 AceView cDNA sequences (see all 182): BI754447 BU681984 BM966832 BC000809 BM665401 BF431895 BE350778 BM666502 AI215599 AW518587 CA431383 AW157800 BM315031 N22292 AI097048 AA902540 BM708086 BQ921040 BU535527 BM128779 BX283384 AI004196 BF516238 BI756079
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
|---|
|
| SP1: | | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for TCEAL1
|
Expression
for TCEAL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCEAL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGATGTAC
About this image
See TCEAL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCEAL1
SOURCE GeneReport for Unigene cluster: Hs.95243
UniProtKB/Swiss-Prot: TCAL1_HUMAN, Q15170Tissue specificity: Expressed in all tissues examined. Highly expressed in heart, ovary, prostate and skeletal muscle.Moderately expressed in brain, placenta, testis and small intestine. Weakly expressed in lung, liver and spleen.Expressed in several cancer cell lines
SABiosciences Custom PCR Arrays for TCEAL1
Primer
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Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEAL1 |
Orthologs
for TCEAL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for TCEAL1 gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tceal11 , 5 |
transcription elongation factor A (SII)-like 11, 5 |
80.71(n)1
84.28(a)1 |
|
X (59.10 cM)5
2370521 NM_146236.11 NP_666348.11
1367079825 |
ENSEMBL Gene Tree for TCEAL1 (if available)
TreeFam Gene Tree for TCEAL1 (if available) |
Paralogs
for TCEAL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TCEAL1 gene
- WBP52 TCEAL82 TCEAL72
3 SIMAP similar genes for TCEAL1 using alignment to 1 protein entry: TCAL1_HUMAN:WBP5 TCEAL7 TCEAL8
TCEAL1 for paralogs About GeneDecksing
|
Genomic Variants
for TCEAL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TCEAL1 (102883632 - 102885881 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TCEAL1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCEAL1 |
|
Disorders
/ Diseases
for TCEAL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCEAL1 for disorders About GeneDecksing
OMIM gene information: 300237
OMIM disorders: --
17  diseases for TCEAL1: About MalaCardsopen-angle glaucoma primary open angle glaucoma chronic obstructive pulmonary disease glaucoma
pulmonary disease multiple sclerosis cervical cancer esophageal cancer
t-cell leukemia esophagitis cervicitis ovarian cancer
breast cancer sarcoma leukemia prostatitis
carcinoma
Genetic Association Database (GAD): TCEAL1
Human Genome Epidemiology (HuGE) Navigator: TCEAL1 (8 documents)
Export disorders for TCEAL1 gene to outside databases
|
Publications
for TCEAL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCEAL1 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with TCEAL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII. (PubMed id 8206389)1, 2, 3, 9 Yeh C.-H. and Shatkin A.J. (1994)
- Association between TP53 and p21 genetic polymorphisms and acute side effects of radiotherapy in breast cancer patients. (PubMed id 16331344)1, 4 Tan X.L....Chang-Claude J. (2006)
- TP53 and P21 polymorphisms: response to cisplatinum/paclitaxel-based chemotherapy in ovarian cancer. (PubMed id 16364249)1, 4 Santos A.M....Medeiros R. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- A polymorphism at codon 31 of gene p21 is not associated with primary open angle glaucoma in Caucasians. (PubMed id 15807891)1, 4 Ressiniotis T....Birch M. (2005)
- Lack of evidence that proline homozygosity at codon 72 of p53 and rare arginine allele at codon 31 of p21, jointly mediate cervical cancer susceptibility among Indian women. (PubMed id 16054204)1, 4 Bhattacharya P. and Sengupta S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Polymorphisms in codon 31 of p21 and cervical cancer susceptibility in Korean women. (PubMed id 11248419)1, 4 Roh J....Lee H. (2001)
- Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR. (PubMed id 10051408)1, 2 Pillutla R.C.... Shatkin A.J. (1999)
- The Ser36-Ser37 pair in HeLa nuclear protein p21/SIIR mediates Ser/Thr phosphorylation and is essential for Rous sarcoma virus long terminal repeat repression. (PubMed id 7592688)1, 2 Yeh C.-H.... Shatkin A.J. (1995)
|
External Searches for TCEAL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TCEAL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCEAL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCEAL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TCEAL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TCEAL1 gene:
Search GeneIP for patents involving TCEAL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCEAL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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