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Aliases for TCEAL1 Gene

Aliases for TCEAL1 Gene

  • Transcription Elongation Factor A Like 1 2 3 5
  • Transcription Elongation Factor S-II Protein-Like 1 3 4
  • Transcription Elongation Factor A (SII)-Like 1 2 3
  • Nuclear Phosphoprotein P21/SIIR 3 4
  • TCEA-Like Protein 1 3 4
  • SIIR 3 4
  • Transcription Elongation Factor A Protein-Like 1 3
  • WEX9 3
  • Pp21 3
  • P21 3

External Ids for TCEAL1 Gene

Previous GeneCards Identifiers for TCEAL1 Gene

  • GC0XP098185
  • GC0XP099792
  • GC0XP100916
  • GC0XP101655
  • GC0XP102690
  • GC0XP102770
  • GC0XP102883
  • GC0XP092540

Summaries for TCEAL1 Gene

Entrez Gene Summary for TCEAL1 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEAL1 Gene

TCEAL1 (Transcription Elongation Factor A Like 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TCEAL9.

UniProtKB/Swiss-Prot for TCEAL1 Gene

  • May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.

Gene Wiki entry for TCEAL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL1 Gene

Genomics for TCEAL1 Gene

Regulatory Elements for TCEAL1 Gene

Enhancers for TCEAL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF103585 0.2 ENCODE 12.8 -44.0 -44002 0.3 TCEAL3 TCEAL1 TCEAL3-AS1 LOC105373300 TCEAL4
GH0XF103655 0.6 ENCODE 12.6 +29.0 28982 4.2 SOX13 TBP JUN MAX BRCA1 RFX5 ZFHX2 GATA3 CTBP1 ZNF366 BEX4 MORF4L2-AS1 MORF4L2 TCEAL3 ZCCHC18 TCEAL1 TCEAL3-AS1 BHLHB9 PLP1 FAM199X
GH0XF103584 0.5 ENCODE 12.6 -42.7 -42712 2.2 PKNOX1 MLX CREB3L1 NFRKB SIN3A YY1 ZNF766 GLIS2 ZNF366 EGR2 TCEAL3 TCEAL1 TCEAL3-AS1 TCEAL4 BEX4 LOC105373300 ENSG00000279894
GH0XF103664 0.2 Ensembl 12.5 +35.6 35597 0.6 MORF4L2 MORF4L2-AS1 TCEAL3 TCEAL1 TCEAL3-AS1 PLP1 BEX4 LOC100130176
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TCEAL1 on UCSC Golden Path with GeneCards custom track

Promoters for TCEAL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000480645 496 2800 PKNOX1 ARID4B SIN3A DMAP1 YY1 GLIS2 ZNF143 KLF7 ZNF263 SP3

Genomic Location for TCEAL1 Gene

Chromosome:
X
Start:
103,628,704 bp from pter
End:
103,630,953 bp from pter
Size:
2,250 bases
Orientation:
Plus strand

Genomic View for TCEAL1 Gene

Genes around TCEAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL1 Gene

Proteins for TCEAL1 Gene

  • Protein details for TCEAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15170-TCAL1_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 1
    Protein Accession:
    Q15170
    Secondary Accessions:
    • Q9UJQ9

    Protein attributes for TCEAL1 Gene

    Size:
    157 amino acids
    Molecular mass:
    18354 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCEAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEAL1 Gene

Post-translational modifications for TCEAL1 Gene

  • Phosphorylation of Ser-36 and Ser-37 is critical for transcriptional repression.
  • Ubiquitination at Lys 136
  • Modification sites at PhosphoSitePlus

Other Protein References for TCEAL1 Gene

No data available for DME Specific Peptides for TCEAL1 Gene

Domains & Families for TCEAL1 Gene

Gene Families for TCEAL1 Gene

Protein Domains for TCEAL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15170

UniProtKB/Swiss-Prot:

TCAL1_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL1: view

Function for TCEAL1 Gene

Molecular function for TCEAL1 Gene

GENATLAS Biochemistry:
transcription elongation factor A-like 1,widely expressed,modulating transcription in a promoter context-dependent fashion
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.

Gene Ontology (GO) - Molecular Function for TCEAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 7971997
GO:0050699 WW domain binding IBA --
genes like me logo Genes that share ontologies with TCEAL1: view
genes like me logo Genes that share phenotypes with TCEAL1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEAL1 Gene

Localization for TCEAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEAL1 Gene COMPARTMENTS Subcellular localization image for TCEAL1 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TCEAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7971997
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TCEAL1: view

Pathways & Interactions for TCEAL1 Gene

SuperPathways for TCEAL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCEAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 7971997
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCEAL1: view

No data available for Pathways by source and SIGNOR curated interactions for TCEAL1 Gene

Drugs & Compounds for TCEAL1 Gene

(2) Drugs for TCEAL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for TCEAL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TCEAL1: view

Transcripts for TCEAL1 Gene

Unigene Clusters for TCEAL1 Gene

Transcription elongation factor A (SII)-like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -
SP6:

Relevant External Links for TCEAL1 Gene

GeneLoc Exon Structure for
TCEAL1
ECgene alternative splicing isoforms for
TCEAL1

Expression for TCEAL1 Gene

mRNA expression in normal human tissues for TCEAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TCEAL1 Gene

This gene is overexpressed in Urinary Bladder (16.3), Ovary (13.1), Prostate (11.1), Testis (8.2), and Blymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCEAL1 Gene



Protein tissue co-expression partners for TCEAL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCEAL1 Gene:

TCEAL1

SOURCE GeneReport for Unigene cluster for TCEAL1 Gene:

Hs.95243

mRNA Expression by UniProt/SwissProt for TCEAL1 Gene:

Q15170-TCAL1_HUMAN
Tissue specificity: Expressed in all tissues examined. Highly expressed in heart, ovary, prostate and skeletal muscle. Moderately expressed in brain, placenta, testis and small intestine. Weakly expressed in lung, liver and spleen. Expressed in several cancer cell lines.
genes like me logo Genes that share expression patterns with TCEAL1: view

Primer Products

No data available for mRNA differential expression in normal tissues for TCEAL1 Gene

Orthologs for TCEAL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL1 34 35
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia TCEAL1 34 35
  • 88.89 (n)
cow
(Bos Taurus)
Mammalia TCEAL1 34 35
  • 84.28 (n)
mouse
(Mus musculus)
Mammalia Tceal1 34 16 35
  • 74.63 (n)
rat
(Rattus norvegicus)
Mammalia Tceal1 34
  • 74.21 (n)
Species where no ortholog for TCEAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL1 Gene

ENSEMBL:
Gene Tree for TCEAL1 (if available)
TreeFam:
Gene Tree for TCEAL1 (if available)

Paralogs for TCEAL1 Gene

Paralogs for TCEAL1 Gene

(3) SIMAP similar genes for TCEAL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCEAL1: view

Variants for TCEAL1 Gene

Sequence variations from dbSNP and Humsavar for TCEAL1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1052145 -- 103,630,116(+) GGAGC(G/T)CCCTC upstream-variant-2KB, reference, missense
rs1052146 -- 103,630,158(+) TGAGG(G/T)GCGCC upstream-variant-2KB, reference, missense
rs1052147 -- 103,630,159(+) GAGGG(G/T)CGCCC upstream-variant-2KB, reference, synonymous-codon
rs1052148 -- 103,630,204(+) CATAA(C/G)CTTGA upstream-variant-2KB, reference, missense
rs1052149 -- 103,630,218(+) AGGAA(G/T)CTTTA upstream-variant-2KB, reference, missense

Variation tolerance for TCEAL1 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEAL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL1 Gene

Disorders for TCEAL1 Gene

Relevant External Links for TCEAL1

Genetic Association Database (GAD)
TCEAL1
Human Genome Epidemiology (HuGE) Navigator
TCEAL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEAL1

No disorders were found for TCEAL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL1 Gene

Publications for TCEAL1 Gene

  1. A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII. (PMID: 8206389) Yeh C.-H. … Shatkin A.J. (Gene 1994) 2 3 4 22 64
  2. Polymorphisms in cell cycle regulatory genes, urinary arsenic profile and urothelial carcinoma. (PMID: 18640142) Chung C.J. … Hsueh Y.M. (Toxicol. Appl. Pharmacol. 2008) 3 46 64
  3. Association between TP53 and p21 genetic polymorphisms and acute side effects of radiotherapy in breast cancer patients. (PMID: 16331344) Tan X.L. … Chang-Claude J. (Breast Cancer Res. Treat. 2006) 3 46 64
  4. TP53 and P21 polymorphisms: response to cisplatinum/paclitaxel-based chemotherapy in ovarian cancer. (PMID: 16364249) Santos A.M. … Medeiros R. (Biochem. Biophys. Res. Commun. 2006) 3 46 64
  5. Linking TP53 codon 72 and P21 nt590 genotypes to the development of cervical and ovarian cancer. (PMID: 16542834) Santos A.M. … Medeiros R. (Eur. J. Cancer 2006) 3 46 64

Products for TCEAL1 Gene

Sources for TCEAL1 Gene

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