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Aliases for TCEA3 Gene

Aliases for TCEA3 Gene

  • Transcription Elongation Factor A (SII), 3 2 3
  • Transcription Elongation Factor S-II Protein 3 3 4
  • Transcription Elongation Factor TFIIS.H 3 4
  • Transcription Elongation Factor A Protein 3 3
  • Rhabdomyosarcoma Antigen MU-RMS-40.22 3
  • TFIIS.H 3
  • TFIISH 4
  • TFIIS 3

External Ids for TCEA3 Gene

Previous GeneCards Identifiers for TCEA3 Gene

  • GC01M023264
  • GC01M022778
  • GC01M023176
  • GC01M023177
  • GC01M023453
  • GC01M023580
  • GC01M023706
  • GC01M021959

Summaries for TCEA3 Gene

GeneCards Summary for TCEA3 Gene

TCEA3 (Transcription Elongation Factor A (SII), 3) is a Protein Coding gene. Among its related pathways are Assembly of RNA Polymerase-II Initiation Complex. An important paralog of this gene is TCEA2.

UniProtKB/Swiss-Prot for TCEA3 Gene

  • Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEA3 Gene

Genomics for TCEA3 Gene

Regulatory Elements for TCEA3 Gene

Genomic Location for TCEA3 Gene

Start:
23,381,061 bp from pter
End:
23,424,776 bp from pter
Size:
43,716 bases
Orientation:
Minus strand

Genomic View for TCEA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEA3 Gene

Proteins for TCEA3 Gene

  • Protein details for TCEA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75764-TCEA3_HUMAN
    Recommended name:
    Transcription elongation factor A protein 3
    Protein Accession:
    O75764
    Secondary Accessions:
    • A8K2K7
    • Q5DR83

    Protein attributes for TCEA3 Gene

    Size:
    348 amino acids
    Molecular mass:
    38972 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCEA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEA3 Gene

Proteomics data for TCEA3 Gene at MOPED

Post-translational modifications for TCEA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEA3 Gene

No data available for DME Specific Peptides for TCEA3 Gene

Domains for TCEA3 Gene

Graphical View of Domain Structure for InterPro Entry

O75764

UniProtKB/Swiss-Prot:

TCEA3_HUMAN :
  • O75764
Domain:
  • Contains 1 TFIIS central domain.
  • Contains 1 TFIIS N-terminal domain.
Family:
  • Belongs to the TFS-II family.
Similarity:
  • Contains 1 TFIIS-type zinc finger.
genes like me logo Genes that share domains with TCEA3: view

No data available for Gene Families for TCEA3 Gene

Function for TCEA3 Gene

Molecular function for TCEA3 Gene

UniProtKB/Swiss-Prot Function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus

Gene Ontology (GO) - Molecular Function for TCEA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TCEA3: view

miRNA for TCEA3 Gene

miRTarBase miRNAs that target TCEA3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TCEA3 Gene

Localization for TCEA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEA3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEA3 Gene COMPARTMENTS Subcellular localization image for TCEA3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TCEA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCEA3: view

Pathways for TCEA3 Gene

genes like me logo Genes that share pathways with TCEA3: view

Pathways by source for TCEA3 Gene

1 Qiagen pathway for TCEA3 Gene

Interacting Proteins for TCEA3 Gene

Gene Ontology (GO) - Biological Process for TCEA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0032784 regulation of DNA-templated transcription, elongation IEA --
genes like me logo Genes that share ontologies with TCEA3: view

Compounds for TCEA3 Gene

(2) Novoseek inferred chemical compound relationships for TCEA3 Gene

Compound -log(P) Hits PubMed IDs
6-azauracil 86.3 2
zinc 24.1 6
genes like me logo Genes that share compounds with TCEA3: view

Transcripts for TCEA3 Gene

Unigene Clusters for TCEA3 Gene

Transcription elongation factor A (SII), 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCEA3 Gene

No ASD Table

Relevant External Links for TCEA3 Gene

GeneLoc Exon Structure for
TCEA3
ECgene alternative splicing isoforms for
TCEA3

Expression for TCEA3 Gene

mRNA expression in normal human tissues for TCEA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCEA3 Gene

This gene is overexpressed in Muscle - Skeletal (11.1) and Pancreas (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCEA3 Gene

SOURCE GeneReport for Unigene cluster for TCEA3 Gene Hs.446354

genes like me logo Genes that share expressions with TCEA3: view

No data available for mRNA Expression by UniProt/SwissProt for TCEA3 Gene

Orthologs for TCEA3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TCEA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEA3 35
  • 99.63 (n)
  • 100 (a)
TCEA3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCEA3 35
  • 91.57 (n)
  • 93.39 (a)
TCEA3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
TCEA3 35
  • 91.55 (n)
  • 94.24 (a)
mouse
(Mus musculus)
Mammalia Tcea3 35
  • 87.96 (n)
  • 88.73 (a)
Tcea3 16
Tcea3 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCEA3 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCEA3 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcea3 35
  • 87.13 (n)
  • 87.32 (a)
chicken
(Gallus gallus)
Aves TCEA3 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCEA3 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.408 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tcea3 35
  • 65.91 (n)
  • 67.29 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.15634 35
tcea3 35
  • 70.31 (n)
  • 74.3 (a)
tcea3 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009035 35
  • 55.56 (n)
  • 49.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8117 36
  • 49 (a)
ManyToMany
TfIIS 35
  • 56.16 (n)
  • 50.8 (a)
TfIIS 36
  • 51 (a)
ManyToMany
CG8117 37
  • 48 (a)
TfIIS 37
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea T24H10.1 36
  • 41 (a)
OneToMany
T24H10.1 37
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DST1 36
  • 26 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1814 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2769 36
  • 46 (a)
OneToMany
Species with no ortholog for TCEA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCEA3 Gene

ENSEMBL:
Gene Tree for TCEA3 (if available)
TreeFam:
Gene Tree for TCEA3 (if available)

Paralogs for TCEA3 Gene

Paralogs for TCEA3 Gene

Selected SIMAP similar genes for TCEA3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TCEA3: view

Variants for TCEA3 Gene

Sequence variations from dbSNP and Humsavar for TCEA3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs592112 -- 23,382,996(-) cggcc(A/T)ATAAT intron-variant, downstream-variant-500B
rs605468 -- 23,384,312(-) CCTGT(C/T)ATCCA intron-variant, missense, reference
rs607675 -- 23,383,849(-) CAAGT(C/T)TGTAA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs619274 -- 23,383,559(-) CTCAT(C/G)CTGAG intron-variant, utr-variant-3-prime
rs621691 -- 23,382,996(-) ggccT(A/C)TAATT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TCEA3 Gene

Variant ID Type Subtype PubMed ID
nsv521882 CNV Loss 19592680
esv2745286 CNV Deletion 23290073
nsv512726 CNV Insertion 21212237
esv2558689 CNV Deletion 19546169
esv9540 CNV Loss 19470904
esv2745297 CNV Deletion 23290073
esv2661255 CNV Deletion 23128226
dgv28n67 CNV Loss 20364138

Relevant External Links for TCEA3 Gene

HapMap Linkage Disequilibrium report
TCEA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCEA3 Gene

Disorders for TCEA3 Gene

Relevant External Links for TCEA3

Genetic Association Database (GAD)
TCEA3
Human Genome Epidemiology (HuGE) Navigator
TCEA3
genes like me logo Genes that share disorders with TCEA3: view

No data available for UniProtKB/Swiss-Prot for TCEA3 Gene

Publications for TCEA3 Gene

  1. Identification of novel genes encoding transcription elongation factor TFIIS (TCEA) in vertebrates: conservation of three distinct TFIIS isoforms in frog, mouse, and human. (PMID: 9790746) Labhart P. … Morgan G.T. (Genomics 1998) 2 3 4 23
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3
  5. The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. (PMID: 20178742) Kim J. … Roeder R.G. (Cell 2010) 3

Products for TCEA3 Gene

Sources for TCEA3 Gene

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