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Aliases for TCEA3 Gene

Aliases for TCEA3 Gene

  • Transcription Elongation Factor A3 2 3 5
  • Transcription Elongation Factor S-II Protein 3 3 4
  • Transcription Elongation Factor A (SII), 3 2 3
  • Transcription Elongation Factor TFIIS.H 3 4
  • Transcription Elongation Factor A Protein 3 3
  • Rhabdomyosarcoma Antigen MU-RMS-40.22 3
  • TFIIS.H 3
  • TFIISH 4
  • TFIIS 3

External Ids for TCEA3 Gene

Previous GeneCards Identifiers for TCEA3 Gene

  • GC01M023264
  • GC01M022778
  • GC01M023176
  • GC01M023177
  • GC01M023453
  • GC01M023580
  • GC01M023706
  • GC01M021959

Summaries for TCEA3 Gene

GeneCards Summary for TCEA3 Gene

TCEA3 (Transcription Elongation Factor A3) is a Protein Coding gene. Diseases associated with TCEA3 include Cockayne Syndrome. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is TCEA1.

UniProtKB/Swiss-Prot for TCEA3 Gene

  • Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus.

Additional gene information for TCEA3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEA3 Gene

Genomics for TCEA3 Gene

Regulatory Elements for TCEA3 Gene

Enhancers for TCEA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H023497 1.4 Ensembl ENCODE dbSUPER 17.4 -72.7 -72706 0.6 ELF3 HDGF ATF1 RB1 ARID4B ZNF2 RAD21 YY1 SLC30A9 ZNF143 TCEA3 E2F2 ID3 MDS2 PIR36355 ASAP3
GH01H023420 1.3 ENCODE dbSUPER 18.1 +1.6 1582 5.1 HDGF ATF1 FOXA2 MLX ARID4B DMAP1 YY1 PAF1 SP5 MXD4 ASAP3 ZNF436-AS1 TCEA3 ENSG00000201405 ZNF436 LINC01355 ENSG00000232482
GH01H023393 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.9 +29.9 29920 3 BCOR MAX ZMYM3 RAD21 FOSL1 ZFHX2 ZNF316 POLR2A FOSL2 FOS TCEA3 ZNF436-AS1 ZNF436 ASAP3 GC01M023400 ENSG00000271420
GH01H023435 1.1 Ensembl ENCODE dbSUPER 17.1 -11.9 -11897 2 HDGF KLF1 POLR2A KLF17 ATF7 ATF2 TCEA3 GC01M023439
GH01H023521 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.3 -103.9 -103905 13.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 CBX5 LINC01355 SRSF10 KDM1A HNRNPR ASAP3 ID3 ZNF436 TCEA3 PNRC2 ENSG00000271420
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCEA3 on UCSC Golden Path with GeneCards custom track

Promoters for TCEA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003030 379 1201 ELF3 TBP MLX ARID4B DMAP1 RAD21 RARA MIXL1 THAP11 PAF1

Genomic Locations for TCEA3 Gene

Genomic Locations for TCEA3 Gene
chr1:23,380,909-23,424,779
(GRCh38/hg38)
Size:
43,871 bases
Orientation:
Minus strand
chr1:23,707,554-23,751,261
(GRCh37/hg19)

Genomic View for TCEA3 Gene

Genes around TCEA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEA3 Gene

Proteins for TCEA3 Gene

  • Protein details for TCEA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75764-TCEA3_HUMAN
    Recommended name:
    Transcription elongation factor A protein 3
    Protein Accession:
    O75764
    Secondary Accessions:
    • A8K2K7
    • Q5DR83

    Protein attributes for TCEA3 Gene

    Size:
    348 amino acids
    Molecular mass:
    38972 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCEA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEA3 Gene

Post-translational modifications for TCEA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCEA3 Gene

Domains & Families for TCEA3 Gene

Gene Families for TCEA3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

O75764

UniProtKB/Swiss-Prot:

TCEA3_HUMAN :
  • Belongs to the TFS-II family.
Family:
  • Belongs to the TFS-II family.
genes like me logo Genes that share domains with TCEA3: view

Function for TCEA3 Gene

Molecular function for TCEA3 Gene

UniProtKB/Swiss-Prot Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus.

Phenotypes From GWAS Catalog for TCEA3 Gene

Gene Ontology (GO) - Molecular Function for TCEA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TCEA3: view
genes like me logo Genes that share phenotypes with TCEA3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEA3 Gene

Localization for TCEA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEA3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEA3 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCEA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCEA3: view

Pathways & Interactions for TCEA3 Gene

genes like me logo Genes that share pathways with TCEA3: view

Pathways by source for TCEA3 Gene

1 Qiagen pathway for TCEA3 Gene

Gene Ontology (GO) - Biological Process for TCEA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCEA3: view

No data available for SIGNOR curated interactions for TCEA3 Gene

Drugs & Compounds for TCEA3 Gene

(1) Drugs for TCEA3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TCEA3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TCEA3: view

Transcripts for TCEA3 Gene

Unigene Clusters for TCEA3 Gene

Transcription elongation factor A (SII), 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEA3 Gene

No ASD Table

Relevant External Links for TCEA3 Gene

GeneLoc Exon Structure for
TCEA3
ECgene alternative splicing isoforms for
TCEA3

Expression for TCEA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCEA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCEA3 Gene

This gene is overexpressed in Muscle - Skeletal (x11.1) and Pancreas (x4.9).

Protein differential expression in normal tissues from HIPED for TCEA3 Gene

This gene is overexpressed in Pancreas (17.6), Placenta (13.5), Breast (12.8), and Heart (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCEA3 Gene



Protein tissue co-expression partners for TCEA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCEA3 Gene:

TCEA3

SOURCE GeneReport for Unigene cluster for TCEA3 Gene:

Hs.446354

Evidence on tissue expression from TISSUES for TCEA3 Gene

  • Intestine(4.3)
  • Liver(4.3)
  • Spleen(4.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with TCEA3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEA3 Gene

Orthologs for TCEA3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TCEA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEA3 34 33
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 93 (a)
OneToMany
TCEA3 33
  • 91.55 (n)
-- 34
  • 63 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TCEA3 33 34
  • 91.57 (n)
mouse
(Mus musculus)
Mammalia Tcea3 34 16 33
  • 87.96 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcea3 33
  • 87.13 (n)
oppossum
(Monodelphis domestica)
Mammalia TCEA3 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCEA3 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCEA3 34
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCEA3 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcea3 33
  • 65.91 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.408 33
zebrafish
(Danio rerio)
Actinopterygii tcea3 34 33
  • 70.31 (n)
OneToOne
Dr.15634 33
fruit fly
(Drosophila melanogaster)
Insecta TfIIS 35 33 34
  • 56.16 (n)
CG8117 35 34
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009035 33
  • 55.56 (n)
worm
(Caenorhabditis elegans)
Secernentea T24H10.1 35 34
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DST1 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2769 34
  • 46 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1814 33
Species where no ortholog for TCEA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCEA3 Gene

ENSEMBL:
Gene Tree for TCEA3 (if available)
TreeFam:
Gene Tree for TCEA3 (if available)

Paralogs for TCEA3 Gene

Paralogs for TCEA3 Gene

(3) SIMAP similar genes for TCEA3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TCEA3: view

Variants for TCEA3 Gene

Sequence variations from dbSNP and Humsavar for TCEA3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000375672 -- 23,403,715(+) CTGTC(A/G)CCCTT intron-variant
rs1000421758 -- 23,391,935(+) AAGCA(A/C)ACAAA intron-variant
rs1000426431 -- 23,407,950(+) TTTCT(G/T)TTTTG intron-variant
rs1000579563 -- 23,403,062(+) AGGAC(A/C)CAGGC intron-variant
rs1000645599 -- 23,422,389(+) CCGTA(A/G)GCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCEA3 Gene

Variant ID Type Subtype PubMed ID
nsv521882 CNV loss 19592680
nsv512726 CNV insertion 21212237
nsv1154147 CNV insertion 26484159
nsv1148896 CNV deletion 26484159
nsv1137233 CNV deletion 24896259
nsv1133127 CNV tandem duplication 24896259
nsv1125457 CNV tandem duplication 24896259
esv9540 CNV loss 19470904
esv3585482 CNV loss 21293372
esv2745297 CNV deletion 23290073
esv2745286 CNV deletion 23290073
esv2661255 CNV deletion 23128226
esv2558689 CNV deletion 19546169
dgv28n67 CNV loss 20364138

Variation tolerance for TCEA3 Gene

Residual Variation Intolerance Score: 36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCEA3 Gene

Disorders for TCEA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCEA3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cockayne syndrome
  • cockayne's syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TCEA3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCEA3

Genetic Association Database (GAD)
TCEA3
Human Genome Epidemiology (HuGE) Navigator
TCEA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEA3
genes like me logo Genes that share disorders with TCEA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCEA3 Gene

Publications for TCEA3 Gene

  1. Identification of novel genes encoding transcription elongation factor TFIIS (TCEA) in vertebrates: conservation of three distinct TFIIS isoforms in frog, mouse, and human. (PMID: 9790746) Labhart P … Morgan GT (Genomics 1998) 2 3 4 22 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. TFIIS.h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene. (PMID: 27005522) Liao JM … Lu H (Scientific reports 2016) 3 60
  5. TCEA3 Attenuates Gastric Cancer Growth by Apoptosis Induction. (PMID: 26498664) Li J … Wu J (Medical science monitor : international medical journal of experimental and clinical research 2015) 3 60

Products for TCEA3 Gene

Sources for TCEA3 Gene

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