TCEA2 Gene
protein-coding GIFtS: 49
GCID: GC20P062681
|
|
transcription elongation factor A (SII), 2
| |
Aliases for TCEA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Transcription Elongation Factor A (SII), 21 2 | | Transcription Elongation Factor TFIIS.L2 3 | | TFIIS1 2 | | Transcription Elongation Factor A Protein 22 | | Testis-Specific S-II2 3 | | Transcription Elongation Factor TFIIS.12 | | Transcription Elongation Factor S-II Protein 22 3 | | |
Export aliases for TCEA2 gene to outside databasesPrevious GC identifers: GC20P062572 GC20P063367 GC20P063420 GC20P063414 GC20P062158 GC20P059422 |
Summaries for TCEA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for TCEA2: The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongationfactor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes fromtranscriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact withgeneral transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoformshave been found for this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: TCEA2_HUMAN, Q15560Function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. Thearresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that passthrough, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption ofelongation from the new 3'-terminus Gene Wiki entry for TCEA2
|
Genomic Views for TCEA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011333.6
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TCEA2 gene promoter: AhR STAT3 Other transcription factors
Search SABiosciences Chromatin IP Primers for TCEA2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEA2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33TCEA2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P062681: view genomic region
(about GC identifiers)
Start:
|
62,681,189 bp from pter |
End:
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62,703,700 bp from pter |
Size:
|
22,512 bases |
Orientation:
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plus strand |
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Proteins for TCEA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TCEA2_HUMAN, Q15560 (See
protein sequence)Recommended Name: Transcription elongation factor A protein 2 Size: 299 amino acids; 33601 Da
Subunit: Interacts with the basal transcription factor GTF2B. Interacts with REXO1
Subcellular location: Nucleus
Caution: It is uncertain whether Met-1 or Met-2 is the initiator
Sequence caution: Sequence=CAD11900.1; Type=Erroneous gene model prediction; Sequence=CAD11901.1; Type=Erroneous genemodel prediction;
1 PDB 3D structure from and Proteopedia for TCEA2:2LW4 (3D)
 
Secondary accessions: Q8TD37 Q8TD38Explore the universe of human proteins at neXtProt for TCEA2: NX_Q15560
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15560 TCEA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_003186.1 NP_942016.1 ENSEMBL proteins: ENSP00000354552 ENSP00000343515 ENSP00000339432 ENSP00000391807 ENSP00000407085 ENSP00000416026 ENSP00000378493 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TCEA2 for ontologies About GeneDecksing
TCEA2 Antibody Products: Assay Products for TCEA2: |
Protein
Domains / Families for TCEA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCEA2 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q15560ProtoNet protein and cluster: Q15560 1 Blocks protein family: IPB003617 Transcription elongation factor S-II
UniProtKB/Swiss-Prot: TCEA2_HUMAN, Q15560Similarity: Belongs to the TFS-II familySimilarity: Contains 1 TFIIS central domainSimilarity: Contains 1 TFIIS N-terminal domainSimilarity: Contains 1 TFIIS-type zinc finger |
Function for TCEA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: TCEA2_HUMAN, Q15560Function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. Thearresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that passthrough, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption ofelongation from the new 3'-terminus Genatlas biochemistry entry for TCEA2:transcription elongation factor A,RNA polymerase II,SII class,testis specific
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCEA2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEA2 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TCEA2 for ontologies About GeneDecksing
|
Pathways & Interactions for TCEA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Assembly of RNA Polymerase-II Initiation Complex | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TCEA2
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCEA2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/82 Interacting proteins for TCEA2 (Q155601, 3 ENSP000003435154) via UniProtKB, MINT, STRING, and/or I2D (see all 82)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
-- | -- | | GO:0006354 | DNA-dependent transcription, elongation |
NAS | 8566795 | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
-- | -- | | GO:0032784 | regulation of DNA-dependent transcription, elongation |
NAS | 8566795 | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
IEA | -- |
TCEA2 for ontologies About GeneDecksing
|
Drugs & Compounds for TCEA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for TCEA2 Search CenterWatch for drugs/clinical trials and news about TCEA2 
|
Transcripts for TCEA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TCEA2 gene (2 alternative transcripts): NM_003195.4 NM_198723.1 Unigene Cluster for TCEA2: Transcription elongation factor A (SII), 2 Hs.505004 [show with all ESTs]Unigene Representative Sequence: AK22614017 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000475792 ENST00000361317(uc021wgo.1 uc021wgp.1) ENST00000343484(uc021wgq.1) ENST00000487164 ENST00000476113 ENST00000339217 ENST00000415602 ENST00000440819 ENST00000470559 ENST00000465111 ENST00000458442(uc010gku.2) ENST00000465433 ENST00000477783 ENST00000495168 ENST00000461072 ENST00000475236 ENST00000395053
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCEA2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCEA2 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TCEA2 (NM_198723) | |  | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AJ844626.2 AJ844627.1 AK027824.1 AK226140.1 BC018896.2 BC050623.1 BC063636.1 BC098585.1 CR456940.1 D50495.1 17 DOTS entries: DT.452526 DT.95196961 DT.101980950 DT.100779219 DT.100779215 DT.91746655 DT.95301156 DT.100028499 DT.100779218 DT.92418567 DT.120834156 DT.92054039 DT.100836239 DT.75200298 DT.120834153 DT.40246815 DT.120834134 24/244 AceView cDNA sequences (see all 244): BU726924 BU732123 BC056407 BU738818 CR620029 CK821065 CR614332 BC050623 AA364355 CA771110 BU631299 BM688157 AA719685 BM923751 AL550885 BM717261 AA399204 BX351159 CR610250 BU726259 AA044683 CD677887 AA448332 BM676452 GeneLoc Exon Structure
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Expression for TCEA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCEA2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See TCEA2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TCEA2
SOURCE GeneReport for Unigene cluster: Hs.505004 UniProtKB/Swiss-Prot: TCEA2_HUMAN, Q15560Tissue specificity: Testis and ovary specific SABiosciences Custom PCR Arrays for TCEA2
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCEA2 Browse OriGene validated miRNA SYBR primer pairs
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Orthologs for TCEA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TCEA2 gene from 8/27 species (see all 27) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
TCEA21 |
transcription elongation factor A (SII), 2 |
75.5(n) 80.87(a) |
  |
419253 XM_417425.3 XP_417425.2 |
lizard (Anolis carolinensis) |
Reptilia |
---- |
-- |
83(a)80(a) |
1 ↔ many1 ↔ many |
LGc(1196946-1197491) 4(155353864-155373943) |
African clawed frog (Xenopus laevis) |
Amphibia |
LOC3980662 |
transcription elongation factor type xTFIIS.l |
77.03(n) |
  |
U57837.1 |
zebrafish (Danio rerio) |
Actinopterygii |
zgc563252 |
similar to transcription elongation factor A (SII), more |
77.88(n) |
  |
393961 BC046074.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
TfIIS3 |
RNA elongation from Pol II promoter transcription more |
60(a) (best of 2) |
  |
-- |
worm (Caenorhabditis elegans) |
Secernentea |
T24H10.13 |
transcription factor S-II |
41(a) |
  |
II(9099286-9100363) -- |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
TFIIS6 |
transcript elongation factor IIS |
24(a) |
1 → many |
2(16134638-16136695) |
rice (Oryza sativa) |
Liliopsida |
---- |
transcription elongation factor protein, putative,...transcription elongation factor protein, putative,... |
25(a)23(a) |
many ↔ manymany ↔ many |
7(7223598-7227248) 3(34187752-34190862) |
ENSEMBL Gene Tree for TCEA2 (if available) TreeFam Gene Tree for TCEA2 (if available)  |
Paralogs for TCEA2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TCEA2 gene
- TCEA32 TCEA12 TCEANC2
6 SIMAP similar genes for TCEA2 using alignment to 6 protein entries: TCEA2_HUMAN (see all proteins):TCEA1 TCEB3 TCEA3 TCEANC PHF3 SPOCD1
TCEA2 for paralogs About GeneDecksing
|
Genomic Variants for TCEA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 20 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for TCEA2 (62681189 - 62703700 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for TCEA2 1 CNV: 4108  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCEA2 |
|
Disorders
/ Diseases for TCEA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCEA2 for disorders About GeneDecksing
OMIM gene information: 604784
OMIM disorders: --
3 diseases for TCEA2: About MalaCardseaf conjunctivitis malaria Export disorders for TCEA2 gene to outside databases
|
Publications for TCEA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCEA2 gene, integrated from 9 sources (see all 24): (articles sorted by number of sources associating them with TCEA2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Genomic characterization of a testis-specific TFIIS (TCEA2) gene. (PubMed id 9441762)1, 2, 3, 9 Weaver Z.A. and Kane C.M. (1997)
- Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II. (PubMed id 8566795)1, 2, 3 Umehara T.... Horikoshi M. (1995)
- Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. (PubMed id 18655026)1, 2 Tan F....Peng X. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain. (PubMed id 12943681)1, 2 Tamura K.... Aso T. (2003)
- RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage. (PubMed id 12034815)1, 2 Sijbrandi R.... Timmers H.T.M. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS. (PubMed id 16214896)1, 9 Palangat M.... Landick R. (2005)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
|
External Searches for TCEA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TCEA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCEA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCEA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for TCEA2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TCEA2 gene: Search GeneIP for patents involving TCEA2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TCEA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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