Aliases for TCEA2 Gene
External Ids for TCEA2 Gene
The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TCEA2 Gene
TCEA2 (Transcription Elongation Factor A (SII), 2) is a Protein Coding gene. Among its related pathways are Assembly of RNA Polymerase-II Initiation Complex. An important paralog of this gene is TCEA1.
UniProtKB/Swiss-Prot for TCEA2 Gene
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus.