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TCEA2 Gene

protein-coding   GIFtS: 52
GCID: GC20P062681

Transcription Elongation Factor A (SII), 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transcription Elongation Factor A (SII), 21 2     TFIIS2
Testis-Specific S-II2 3     Transcription Elongation Factor A Protein 22
Transcription Elongation Factor S-II Protein 22 3     Transcription Elongation Factor TFIIS.12
Transcription Elongation Factor TFIIS.L2 3     

External Ids:    HGNC: 116141   Entrez Gene: 69192   Ensembl: ENSG000001717037   OMIM: 6047845   UniProtKB: Q155603   
ORGUL members:         

Export aliases for TCEA2 gene to outside databases

Previous GC identifers: GC20P062572 GC20P063367 GC20P063420 GC20P063414 GC20P062158 GC20P059422


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCEA2 Gene:
The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription
elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary
complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to
interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TCEA2 Gene:
TCEA2 (transcription elongation factor A (SII), 2) is a protein-coding gene. Diseases associated with TCEA2 include eaf, and conjunctivitis. An important paralog of this gene is TCEA3.

UniProtKB/Swiss-Prot: TCEA2_HUMAN, Q15560
Function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting
sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases
that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the
resumption of elongation from the new 3'-terminus

Gene Wiki entry for TCEA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCEA2 gene promoter:
         AhR   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TCEA2 promoter sequence
   Search Chromatin IP Primers for TCEA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCEA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

TCEA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEA2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P062681:  view genomic region     (about GC identifiers)

Start:
62,681,189 bp from pter      End:
62,703,700 bp from pter
Size:
22,512 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TCEA2_HUMAN, Q15560 (See protein sequence)
Recommended Name: Transcription elongation factor A protein 2  
Size: 299 amino acids; 33601 Da
Subunit: Interacts with the basal transcription factor GTF2B. Interacts with REXO1
Caution: It is uncertain whether Met-1 or Met-2 is the initiator
Sequence caution: Sequence=CAD11900.1; Type=Erroneous gene model prediction; Sequence=CAD11901.1; Type=Erroneous
gene model prediction;
1 PDB 3D structure from and Proteopedia for TCEA2:
2LW4 (3D)    
Secondary accessions: B3KNM1 Q8TD37 Q8TD38
Alternative splicing: 2 isoforms:  Q15560-1   Q15560-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TCEA2: NX_Q15560

Explore proteomics data for TCEA2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys58
  • Modification sites at PhosphoSitePlus

  • See TCEA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003186.1  NP_942016.1  

    ENSEMBL proteins: 
     ENSP00000354552   ENSP00000343515   ENSP00000339432   ENSP00000391807   ENSP00000407085  
     ENSP00000416026   ENSP00000378493  

    TCEA2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR003617 TFIIS/CRSP70_N_sub
     IPR001222 Znf_TFIIS
     IPR003618 TFIIS_cen_dom
     IPR017923 TFIIS_N
     IPR017890 TFS2M

    Graphical View of Domain Structure for InterPro Entry Q15560

    ProtoNet protein and cluster: Q15560

    1 Blocks protein domain: IPB003617 Transcription elongation factor S-II

    UniProtKB/Swiss-Prot: TCEA2_HUMAN, Q15560
    Similarity: Belongs to the TFS-II family
    Similarity: Contains 1 TFIIS central domain
    Similarity: Contains 1 TFIIS N-terminal domain
    Similarity: Contains 1 TFIIS-type zinc finger


    TCEA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCEA2_HUMAN, Q15560
    Function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting
    sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases
    that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the
    resumption of elongation from the new 3'-terminus

         Genatlas biochemistry entry for TCEA2:
    transcription elongation factor A,RNA polymerase II,SII class,testis specific

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003746translation elongation factor activity ----
    GO:0005515protein binding IPI16169070
    GO:0008270zinc ion binding IEA--
         
    TCEA2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCEA2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCEA2
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    miRNA
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    miRTarBase miRNAs that target TCEA2:
    hsa-mir-17-5p (MIRT051001), hsa-mir-18a-5p (MIRT050731)

    Block miRNA regulation of human, mouse, rat TCEA2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TCEA2:
    hsa-miR-525-5p hsa-miR-494 hsa-miR-3919 hsa-miR-766 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidTCEA2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TCEA2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): TCEA2 (NM_198723)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCEA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEA2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCEA2_HUMAN, Q15560: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005813centrosome IDA--
    GO:0008023transcription elongation factor complex NAS8566795

    TCEA2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TCEA2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Assembly of RNA Polymerase-II Initiation Complex
    Transcription of mRNA0.91

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TCEA2
        Transcription of mRNA


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCEA2
    Interactions:

        Search GeneGlobe Interaction Network for TCEA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TCEA2 (Q155601, 3 ENSP000003435154) via UniProtKB, MINT, STRING, and/or I2D (see all 181)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGEA11P433641, 3, ENSP000003473584EBI-710310,EBI-739552 I2D: score=5 STRING: ENSP00000347358
    MARK3P274481, 3EBI-710310,EBI-707595 I2D: score=4 
    RPA1P276943, ENSP000002547194I2D: score=4 STRING: ENSP00000254719
    TRAF2Q129333, ENSP000002476684I2D: score=4 STRING: ENSP00000247668
    WDR47O949673, ENSP000003835994I2D: score=3 STRING: ENSP00000383599
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006354DNA-templated transcription, elongation NAS8566795
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0032784regulation of DNA-templated transcription, elongation NAS8566795

    TCEA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCEA2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TCEA2 gene (2 alternative transcripts): 
    NM_003195.4  NM_198723.1  

    Unigene Cluster for TCEA2:

    Transcription elongation factor A (SII), 2
    Hs.505004  [show with all ESTs]
    Unigene Representative Sequence: AK226140
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475792 ENST00000361317(uc021wgo.1 uc021wgp.1) ENST00000343484(uc021wgq.1)
    ENST00000487164 ENST00000476113 ENST00000339217 ENST00000415602 ENST00000440819
    ENST00000470559 ENST00000465111 ENST00000458442(uc010gku.2) ENST00000465433
    ENST00000477783 ENST00000495168 ENST00000461072 ENST00000475236 ENST00000395053

    miRNA
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    Block miRNA regulation of human, mouse, rat TCEA2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TCEA2:
    hsa-miR-525-5p hsa-miR-494 hsa-miR-3919 hsa-miR-766 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidTCEA2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TCEA2
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    GenScript: all cDNA clones in your preferred vector (see all 2): TCEA2 (NM_198723)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCEA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEA2
    Primer
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    OriGene qPCR primer pairs and template standards for TCEA2
    OriGene qSTAR qPCR primer pairs in human, mouse for TCEA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TCEA2
      QuantiTect SYBR Green Assays in human, mouse, rat TCEA2
      QuantiFast Probe-based Assays in human, mouse, rat TCEA2

    Additional mRNA sequence: 

    AJ844626.2 AJ844627.1 AK027824.1 AK226140.1 BC018896.2 BC050623.1 BC063636.1 BC098585.1 
    CR456940.1 D50495.1 

    16 DOTS entries:

    DT.452526  DT.95196961  DT.101980950  DT.100779219  DT.100779215  DT.91746655  DT.95301156  DT.100028499 
    DT.100779218  DT.92418567  DT.120834156  DT.92054039  DT.100836239  DT.75200298  DT.40246815  DT.120834134 

    Selected AceView cDNA sequences (see all 244):

    AL555331 CR610250 BU726259 BM688157 BG681782 BC014211 BM705762 CR620029 
    BM676452 CA427070 AI858761 BF436787 AI198221 AI884884 BE563029 AA719685 
    BM717261 BU726924 BX351159 CA771110 AW007370 CD677887 BU149617 AL550885 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCEA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TCEA2 Expression
    About this image

    TCEA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCEA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.505004

    UniProtKB/Swiss-Prot: TCEA2_HUMAN, Q15560
    Tissue specificity: Testis and ovary specific

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TCEA2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcea21 , 5 transcription elongation factor A (SII), 21, 5 85.46(n)1
    89.26(a)1
      2 (103.72 cM)5
    214001  NM_009326.21  NP_033352.11 
     1816803105 
    chicken
    (Gallus gallus)
    Aves TCEA21 transcription elongation factor A (SII), 2 76.06(n)
    81.21(a)
      419253  XM_417425.4  XP_417425.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    84(a)
    80(a)
    1 ↔ many
    1 ↔ many
    LGc(1196945-1197491)
    4(155353864-155374485)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980662 transcription elongation factor type xTFIIS.l 77.03(n)    U57837.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc563252 similar to transcription elongation factor A (SII), more 77.88(n)   393961  BC046074.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TfIIS3 RNA elongation from Pol II promoter
    transcription more
    60(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea T24H10.13 transcription factor S-II 41(a)   II(9099286-9100363)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DST11 DST1 43.76(n)
    34.53(a)
      852839   NP_011472.1 


    ENSEMBL Gene Tree for TCEA2 (if available)
    TreeFam Gene Tree for TCEA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCEA2 gene
    TCEA32  TCEA12  TCEANC2  
    7 SIMAP similar genes for TCEA2 using alignment to 6 protein entries:     TCEA2_HUMAN (see all proteins):
    TCEA1    TCEA3    TCEB3    MED26    TCEANC    PHF3
    SPOCD1

    TCEA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCEA2 (see all 437)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1427750711,2
    C--62648694(+) GTGAGG/TGGCAG 1 -- us2k10--------
    rs60900401,2
    C,F,A,H--62648733(+) CtattA/Cataat 1 -- us2k125Minor allele frequency- N:0.00NS EA NA WA CSA 2564
    rs758172631,2
    C--62648784(+) CTTTGC/TTCCTC 1 -- us2k10--------
    rs1506501631,2
    --62648963(+) GGCGCA/GTGCCG 1 -- us2k10--------
    rs1397411261,2
    --62649004(+) TGTATC/TTTAGT 1 -- us2k10--------
    rs60112691,2
    F--62649040(+) caggcC/Tggtct 1 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs1832038191,2
    --62649059(+) TGAGCC/TCAGGC 1 -- us2k10--------
    rs1886150401,2
    --62649093(+) ATTACA/GAGCAT 1 -- us2k10--------
    rs72648021,2
    C,A--62649113(+) cgcccG/AgccTG 1 -- us2k15Minor allele frequency- A:0.10NA WA 10
    rs60112701,2
    C,F--62649273(+) aggcaT/Cgtgcc 1 -- us2k12Minor allele frequency- C:0.00NA 4

    HapMap Linkage Disequilibrium report for TCEA2 (62681189 - 62703700 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TCEA2 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509785CNV Insertion20534489
    esv1663265CNV Insertion17803354
    dgv4661n71CNV Loss21882294
    dgv4659n71CNV Loss21882294
    nsv913313CNV Loss21882294
    nsv913270CNV Loss21882294
    dgv4658n71CNV Loss21882294
    dgv4662n71CNV Loss21882294
    nsv913190CNV Loss21882294
    nsv913314CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604784    OMIM disorders: --

    3 diseases for TCEA2:    About MalaCards
    eaf    conjunctivitis    hiv-1


    TCEA2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TCEA2

    Export disorders for TCEA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCEA2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with TCEA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic characterization of a testis-specific TFIIS (TCEA2) gene. (PubMed id 9441762)1, 2, 3, 9 Weaver Z.A. and Kane C.M. (Genomics 1997)
    2. Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II. (PubMed id 8566795)1, 2, 3 Umehara T.... Horikoshi M. (Gene 1995)
    3. Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. (PubMed id 18655026)1, 2 Tan F.... Peng X. (Proteomics 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain. (PubMed id 12943681)1, 2 Tamura K.... Aso T. (Biochem. Biophys. Res. Commun. 2003)
    7. RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage. (PubMed id 12034815)1, 2 Sijbrandi R.... Timmers H.T.M. (Nucleic Acids Res. 2002)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    9. A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS. (PubMed id 16214896)1, 9 Palangat M.... Landick R. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6919 HGNC: 11614 AceView: TCEA2 Ensembl:ENSG00000171703 euGenes: HUgn6919
    ECgene: TCEA2 H-InvDB: TCEA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TCEA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCEA2 gene:
    Search GeneIP for patents involving TCEA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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