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Aliases for TCEA2 Gene

Aliases for TCEA2 Gene

  • Transcription Elongation Factor A (SII), 2 2 3
  • Transcription Elongation Factor S-II Protein 2 3 4
  • Transcription Elongation Factor TFIIS.L 3 4
  • Testis-Specific S-II 3 4
  • Transcription Elongation Factor A Protein 2 3
  • Transcription Elongation Factor TFIIS.1 3
  • TFIIS 3

External Ids for TCEA2 Gene

Summaries for TCEA2 Gene

Entrez Gene Summary for TCEA2 Gene

  • The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEA2 Gene

TCEA2 (Transcription Elongation Factor A (SII), 2) is a Protein Coding gene. Among its related pathways are Assembly of RNA Polymerase-II Initiation Complex. An important paralog of this gene is TCEA1.

UniProtKB/Swiss-Prot for TCEA2 Gene

  • Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus.

Gene Wiki entry for TCEA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEA2 Gene

Genomics for TCEA2 Gene

Genomic Location for TCEA2 Gene

Start:
64,049,836 bp from pter
End:
64,072,347 bp from pter
Size:
22,512 bases
Orientation:
Plus strand

Genomic View for TCEA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEA2 Gene

Regulatory Elements for TCEA2 Gene

Transcription factor binding sites by QIAGEN in the TCEA2 gene promoter:

Proteins for TCEA2 Gene

  • Protein details for TCEA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15560-TCEA2_HUMAN
    Recommended name:
    Transcription elongation factor A protein 2
    Protein Accession:
    Q15560
    Secondary Accessions:
    • B3KNM1
    • Q8TD37
    • Q8TD38

    Protein attributes for TCEA2 Gene

    Size:
    299 amino acids
    Molecular mass:
    33601 Da
    Quaternary structure:
    • Interacts with the basal transcription factor GTF2B. Interacts with REXO1.
    SequenceCaution:
    • Sequence=CAD11900.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAD11901.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TCEA2 Gene

    Alternative splice isoforms for TCEA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEA2 Gene

Proteomics data for TCEA2 Gene at MOPED

Post-translational modifications for TCEA2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys58

Other Protein References for TCEA2 Gene

No data available for DME Specific Peptides for TCEA2 Gene

Domains for TCEA2 Gene

UniProtKB/Swiss-Prot:

TCEA2_HUMAN
Domain:
  • Contains 1 TFIIS central domain.:
    • Q15560
  • Contains 1 TFIIS N-terminal domain.:
    • Q15560
Family:
  • Belongs to the TFS-II family.:
    • Q15560
Similarity:
  • Contains 1 TFIIS-type zinc finger.:
    • Q15560
genes like me logo Genes that share domains with TCEA2: view

No data available for Gene Families for TCEA2 Gene

Function for TCEA2 Gene

Molecular function for TCEA2 Gene

GENATLAS Biochemistry: transcription elongation factor A,RNA polymerase II,SII class,testis specific
UniProtKB/Swiss-Prot Function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus.

Gene Ontology (GO) - Molecular Function for TCEA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003746 translation elongation factor activity --
GO:0005515 protein binding IPI 16169070
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TCEA2: view

miRNA for TCEA2 Gene

miRTarBase miRNAs that target TCEA2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TCEA2 Gene

Localization for TCEA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEA2 Gene COMPARTMENTS Subcellular localization image for TCEA2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TCEA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005813 centrosome IDA --
GO:0008023 transcription elongation factor complex NAS 8566795
genes like me logo Genes that share ontologies with TCEA2: view

Pathways for TCEA2 Gene

genes like me logo Genes that share pathways with TCEA2: view

Pathways by source for TCEA2 Gene

1 Qiagen pathway for TCEA2 Gene

Gene Ontology (GO) - Biological Process for TCEA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006354 DNA-templated transcription, elongation NAS 8566795
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006414 translational elongation --
genes like me logo Genes that share ontologies with TCEA2: view

Transcripts for TCEA2 Gene

Unigene Clusters for TCEA2 Gene

Transcription elongation factor A (SII), 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCEA2 Gene

No ASD Table

Relevant External Links for TCEA2 Gene

GeneLoc Exon Structure for
TCEA2
ECgene alternative splicing isoforms for
TCEA2

Expression for TCEA2 Gene

mRNA expression in normal human tissues for TCEA2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TCEA2 Gene

SOURCE GeneReport for Unigene cluster for TCEA2 Gene Hs.505004

mRNA Expression by UniProt/SwissProt for TCEA2 Gene

Q15560-TCEA2_HUMAN
Tissue specificity: Testis and ovary specific.
genes like me logo Genes that share expressions with TCEA2: view

Orthologs for TCEA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TCEA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEA2 36
  • 99.44 (n)
  • 100 (a)
TCEA2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCEA2 36
  • 89.74 (n)
  • 94.31 (a)
TCEA2 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCEA2 36
  • 89.83 (n)
  • 93.38 (a)
TCEA2 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcea2 36
  • 85.46 (n)
  • 89.26 (a)
Tcea2 16
Tcea2 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCEA2 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCEA2 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcea2 36
  • 86.35 (n)
  • 88.93 (a)
chicken
(Gallus gallus)
Aves TCEA2 36
  • 76.06 (n)
  • 81.21 (a)
TCEA2 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 80 (a)
OneToMany
-- 37
  • 84 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC398066 36
zebrafish
(Danio rerio)
Actinopterygii tcea2 36
  • 69.13 (n)
  • 67.45 (a)
tcea2 37
  • 67 (a)
OneToOne
zgc56325 36
fruit fly
(Drosophila melanogaster)
Insecta CG8117 37
  • 48 (a)
ManyToMany
TfIIS 37
  • 47 (a)
ManyToMany
CG8117 38
  • 47 (a)
TfIIS 38
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea T24H10.1 37
  • 42 (a)
OneToMany
T24H10.1 38
  • 41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR011W 36
  • 46.1 (n)
  • 33.09 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DST1 36
  • 43.76 (n)
  • 34.53 (a)
DST1 37
  • 27 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09361g 36
  • 41.53 (n)
  • 32.38 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02563 36
  • 47.22 (n)
  • 31.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tfs1 36
  • 42.26 (n)
  • 40.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2769 37
  • 45 (a)
OneToMany
Species with no ortholog for TCEA2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TCEA2 Gene

ENSEMBL:
Gene Tree for TCEA2 (if available)
TreeFam:
Gene Tree for TCEA2 (if available)

Paralogs for TCEA2 Gene

Paralogs for TCEA2 Gene

Selected SIMAP similar genes for TCEA2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TCEA2: view

Variants for TCEA2 Gene

Sequence variations from dbSNP and Humsavar for TCEA2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs708631 -- 64,058,201(-) AGGAG(C/T)GGACG intron-variant
rs816950 -- 64,055,664(+) GTGAG(A/G)TGGGA upstream-variant-2KB
rs816951 -- 64,055,815(+) AGGTT(C/T)GCTCT upstream-variant-2KB
rs816952 -- 64,055,827(+) AGACC(C/T)CATCT upstream-variant-2KB
rs816953 -- 64,057,006(+) GGAGA(C/T)GGAAC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TCEA2 Gene

Variant ID Type Subtype PubMed ID
nsv913190 CNV Loss 21882294
nsv428381 CNV Gain+Loss 18775914
nsv913270 CNV Loss 21882294
dgv4654n71 CNV Loss 21882294
nsv509785 CNV Insertion 20534489
dgv1346e1 CNV Complex 17122850
dgv1347e1 CNV Complex 17122850
dgv4658n71 CNV Loss 21882294
dgv4659n71 CNV Loss 21882294
nsv913304 CNV Loss 21882294
nsv470564 CNV Gain 18288195
dgv4661n71 CNV Loss 21882294
dgv4662n71 CNV Loss 21882294
nsv913313 CNV Loss 21882294
esv1663265 CNV Insertion 17803354
nsv913314 CNV Loss 21882294

Relevant External Links for TCEA2 Gene

HapMap Linkage Disequilibrium report
TCEA2

Disorders for TCEA2 Gene

Relevant External Links for TCEA2

Genetic Association Database (GAD)
TCEA2
genes like me logo Genes that share disorders with TCEA2: view

No data available for UniProtKB/Swiss-Prot for TCEA2 Gene

Publications for TCEA2 Gene

  1. Genomic characterization of a testis-specific TFIIS (TCEA2) gene. (PMID: 9441762) Weaver Z.A. … Kane C.M. (Genomics 1997) 2 3 4 23
  2. Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II. (PMID: 8566795) Umehara T. … Horikoshi M. (Gene 1995) 2 3 4
  3. Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. (PMID: 18655026) Tan F. … Peng X. (Proteomics 2008) 3 4
  4. A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS. (PMID: 16214896) Palangat M. … Landick R. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 23
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for TCEA2 Gene

Sources for TCEA2 Gene

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