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Aliases for TCEA1 Gene

Aliases for TCEA1 Gene

  • Transcription Elongation Factor A (SII), 1 2 3
  • Transcription Elongation Factor S-II Protein 1 3 4
  • Transcription Elongation Factor TFIIS.O 3 4
  • TFIIS 3 4
  • GTF2S 3 4
  • TF2S 3
  • TCEA 3
  • SII 3

External Ids for TCEA1 Gene

Previous HGNC Symbols for TCEA1 Gene

  • TCEA
  • GTF2S

Previous GeneCards Identifiers for TCEA1 Gene

  • GC03P036581
  • GC08M054818
  • GC08M054582
  • GC08M054929
  • GC08M055041
  • GC08M050347
  • GC08M054879

Summaries for TCEA1 Gene

GeneCards Summary for TCEA1 Gene

TCEA1 (Transcription Elongation Factor A (SII), 1) is a Protein Coding gene. Diseases associated with TCEA1 include cockayne syndrome. Among its related pathways are Infectious disease and Gene Expression. GO annotations related to this gene include nucleic acid binding and translation elongation factor activity. An important paralog of this gene is TCEA2.

UniProtKB/Swiss-Prot for TCEA1 Gene

  • Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus

Gene Wiki entry for TCEA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEA1 Gene

Genomics for TCEA1 Gene

Regulatory Elements for TCEA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TCEA1 Gene

Chromosome:
8
Start:
53,966,552 bp from pter
End:
54,022,529 bp from pter
Size:
55,978 bases
Orientation:
Minus strand

Genomic View for TCEA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCEA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEA1 Gene

Proteins for TCEA1 Gene

  • Protein details for TCEA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23193-TCEA1_HUMAN
    Recommended name:
    Transcription elongation factor A protein 1
    Protein Accession:
    P23193
    Secondary Accessions:
    • A6NF25
    • A8K339
    • Q15563
    • Q6FG87

    Protein attributes for TCEA1 Gene

    Size:
    301 amino acids
    Molecular mass:
    33970 Da
    Quaternary structure:
    • Interacts with EAF2 (By similarity). Associates with UBR5 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters.
    Miscellaneous:
    • S-II binds to RNA-polymerase II in the absence of transcription

    Three dimensional structures from OCA and Proteopedia for TCEA1 Gene

    Alternative splice isoforms for TCEA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEA1 Gene

Proteomics data for TCEA1 Gene at MOPED

Post-translational modifications for TCEA1 Gene

  • Ubiquitination at Lys 29, Lys 67, and Lys 252
  • Modification sites at PhosphoSitePlus

Other Protein References for TCEA1 Gene

No data available for DME Specific Peptides for TCEA1 Gene

Domains & Families for TCEA1 Gene

Gene Families for TCEA1 Gene

Graphical View of Domain Structure for InterPro Entry

P23193

UniProtKB/Swiss-Prot:

TCEA1_HUMAN :
  • Contains 1 TFIIS central domain.
  • Belongs to the TFS-II family.
  • Contains 1 TFIIS-type zinc finger.
Domain:
  • Contains 1 TFIIS central domain.
  • Contains 1 TFIIS N-terminal domain.
Family:
  • Belongs to the TFS-II family.
Similarity:
  • Contains 1 TFIIS-type zinc finger.
genes like me logo Genes that share domains with TCEA1: view

Function for TCEA1 Gene

Molecular function for TCEA1 Gene

GENATLAS Biochemistry:
transcription elongation factor A for RNA polymerase II,SII class,widely expressed,fused with PLAG1 in translocation (3;8)(p21;q12) in salivary tumors (see PSA2)
UniProtKB/Swiss-Prot Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus

Gene Ontology (GO) - Molecular Function for TCEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003746 translation elongation factor activity --
GO:0005515 protein binding IPI 20178742
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TCEA1: view
genes like me logo Genes that share phenotypes with TCEA1: view

Animal Models for TCEA1 Gene

MGI Knock Outs for TCEA1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TCEA1 Gene

Localization for TCEA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCEA1 Gene COMPARTMENTS Subcellular localization image for TCEA1 gene
Compartment Confidence
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TCEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with TCEA1: view

Pathways & Interactions for TCEA1 Gene

genes like me logo Genes that share pathways with TCEA1: view

Pathways by source for TCEA1 Gene

1 Qiagen pathway for TCEA1 Gene
25 Reactome pathways for TCEA1 Gene

SIGNOR curated interactions for TCEA1 Gene

Activates:

Gene Ontology (GO) - Biological Process for TCEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006289 nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with TCEA1: view

Drugs & Compounds for TCEA1 Gene

No Compound Related Data Available

Transcripts for TCEA1 Gene

Unigene Clusters for TCEA1 Gene

Transcription elongation factor A (SII), 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCEA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEA1 Gene

No ASD Table

Relevant External Links for TCEA1 Gene

GeneLoc Exon Structure for
TCEA1
ECgene alternative splicing isoforms for
TCEA1

Expression for TCEA1 Gene

mRNA expression in normal human tissues for TCEA1 Gene

Protein differential expression in normal tissues from HIPED for TCEA1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.9) and Lymph node (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCEA1 Gene



SOURCE GeneReport for Unigene cluster for TCEA1 Gene Hs.491745

genes like me logo Genes that share expression patterns with TCEA1: view

Protein tissue co-expression partners for TCEA1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TCEA1 Gene

Orthologs for TCEA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TCEA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TCEA1 35
  • 90.03 (n)
  • 96.35 (a)
TCEA1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCEA1 35
  • 93.56 (n)
  • 97.33 (a)
TCEA1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcea1 35
  • 92 (n)
  • 97 (a)
Tcea1 16
Tcea1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TCEA1 35
  • 99.89 (n)
  • 99.67 (a)
TCEA1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC498453 35
  • 92.14 (n)
  • 96.68 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TCEA1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCEA1 35
  • 82.11 (n)
  • 90 (a)
TCEA1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCEA1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76031 35
tcea1 35
  • 75.08 (n)
  • 81.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.238 35
zebrafish
(Danio rerio)
Actinopterygii tcea1 35
  • 74.11 (n)
  • 78 (a)
wufj48e12 35
tcea1 36
  • 75 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1255 35
fruit fly
(Drosophila melanogaster)
Insecta CG8117 37
  • 49 (a)
TfIIS 37
  • 47 (a)
CG8117 36
  • 48 (a)
ManyToMany
TfIIS 36
  • 49 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T24H10.1 37
  • 48 (a)
T24H10.1 35
  • 55.51 (n)
  • 51.67 (a)
T24H10.1 36
  • 43 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DST1 36
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons TFIIS 35
  • 52.93 (n)
  • 40 (a)
rice
(Oryza sativa)
Liliopsida Os07g0229700 35
  • 45.91 (n)
  • 37.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2769 36
  • 47 (a)
OneToMany
Species with no ortholog for TCEA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCEA1 Gene

ENSEMBL:
Gene Tree for TCEA1 (if available)
TreeFam:
Gene Tree for TCEA1 (if available)

Paralogs for TCEA1 Gene

Paralogs for TCEA1 Gene

(4) SIMAP similar genes for TCEA1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for TCEA1 Gene

genes like me logo Genes that share paralogs with TCEA1: view

Variants for TCEA1 Gene

Sequence variations from dbSNP and Humsavar for TCEA1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1050471 -- 53,967,908(-) TAATT(G/T)TATGG utr-variant-3-prime, nc-transcript-variant
rs1050523 -- 53,966,723(-) GGCCC(A/G)CTGGT utr-variant-3-prime, nc-transcript-variant
rs1137607 -- 53,982,002(-) agatc(A/G)cttga intron-variant
rs1137609 -- 53,981,992(-) agtcc(A/G)ggagg intron-variant
rs1137611 -- 53,981,885(-) gtccc(A/G)gctac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCEA1 Gene

Variant ID Type Subtype PubMed ID
essv22151 CNV CNV 17122850
esv2487551 CNV Deletion 19546169

Variation tolerance for TCEA1 Gene

Residual Variation Intolerance Score: 76.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCEA1 Gene

HapMap Linkage Disequilibrium report
TCEA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCEA1 Gene

Disorders for TCEA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCEA1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
cockayne syndrome
  • cs
- elite association
Search TCEA1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TCEA1_HUMAN
  • Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.

Relevant External Links for TCEA1

Genetic Association Database (GAD)
TCEA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCEA1
genes like me logo Genes that share disorders with TCEA1: view

No data available for Genatlas for TCEA1 Gene

Publications for TCEA1 Gene

  1. Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3. (PMID: 8812434) DiMarco S.P. … Warren S.T. (Genomics 1996) 2 23 67
  2. [Mechanisms of action of RNA polymerase-binding transcription factors that do not bind to DNA]. (PMID: 19894614) Stepanova E.V. … Severinov K.V. (Biofizika 2009) 23 67
  3. Analysis of factor interactions with RNA polymerase II elongation complexes using a new electrophoretic mobility shift assay. (PMID: 18832375) Cheng B. … Price D.H. (Nucleic Acids Res. 2008) 23 67
  4. Backtracking determines the force sensitivity of RNAP II in a factor-dependent manner. (PMID: 17361130) Galburt E.A. … Bustamante C. (Nature 2007) 23 67
  5. RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS. (PMID: 17374514) Kuraoka I. … Tanaka K. (DNA Repair (Amst.) 2007) 23 67

Products for TCEA1 Gene

Sources for TCEA1 Gene

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