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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCEA1 Gene

protein-coding   GIFtS: 56
GCID: GC08M054929

Transcription Elongation Factor A (SII), 1


(Previous symbols: TCEA, GTF2S)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcription Elongation Factor A (SII), 11 2     TFIIS2 3
GTF2S1 2 3 5     TF2S2 5
TCEA1 2     SII2
Transcription Elongation Factor S-II Protein 12 3     Transcription Elongation Factor A Protein 12
Transcription Elongation Factor TFIIS.O2 3     

External Ids:    HGNC: 116121   Entrez Gene: 69172   Ensembl: ENSG000001877357   OMIM: 6014255   UniProtKB: P231933   

Export aliases for TCEA1 gene to outside databases

Previous GC identifers: GC03P036581 GC08M054818 GC08M054582 GC08M055041 GC08M050347


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TCEA1 Gene: 
TCEA1 (transcription elongation factor A (SII), 1) is a protein-coding gene. Diseases associated with TCEA1 include eaf, and conjunctivitis, and among its related super-pathways are Formation of the Early Elongation Complex and HIV Life Cycle. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is TCEA3.

UniProtKB/Swiss-Prot: TCEA1_HUMAN, P23193
Function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting
sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases
that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the
resumption of elongation from the new 3'-terminus

Gene Wiki entry for TCEA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCEA1 gene promoter:
         HFH-3   Pax-2   Pax-2a   HNF-3beta   AREB6   FOXI1   POU2F1   COMP1   HFH-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCEA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TCEA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCEA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11.2   Ensembl cytogenetic band:  8q11.23   HGNC cytogenetic band: 8q11.2

TCEA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEA1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M054929:  view genomic region     (about GC identifiers)

Start:
54,879,112 bp from pter      End:
54,935,089 bp from pter
Size:
55,978 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCEA1_HUMAN, P23193 (See protein sequence)
Recommended Name: Transcription elongation factor A protein 1  
Size: 301 amino acids; 33970 Da
Subunit: Interacts with EAF2 (By similarity). Associates with UBR5 and forms a transcription regulatory complex
made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma
fibrinogen/FGG) by recruiting their promoters
Subcellular location: Nucleus
Miscellaneous: S-II binds to RNA-polymerase II in the absence of transcription
2 PDB 3D structures from and Proteopedia for TCEA1:
1TFI (3D)        3NDQ (3D)    
Secondary accessions: A6NF25 A8K339 Q15563 Q6FG87
Alternative splicing: 2 isoforms:  P23193-1   P23193-2   

Explore the universe of human proteins at neXtProt for TCEA1: NX_P23193

Explore proteomics data for TCEA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P23193

  • TCEA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCEA1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_006747.1  NP_958845.1  

    ENSEMBL proteins: 
     ENSP00000395483   ENSP00000428426   ENSP00000429192   ENSP00000428370   ENSP00000428868  
     ENSP00000429182   ENSP00000430450  
    Reactome Protein details: P23193
    Human Recombinant Protein Products for TCEA1: 
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    ProSpec Recombinant Protein for TCEA1
    Cloud-Clone Corp. Proteins for TCEA1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--

    TCEA1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GTF: General transcription factors

    5/7 InterPro protein domains (see all 7):
     IPR003617 TFIIS/CRSP70_N_sub
     IPR001222 Znf_TFIIS
     IPR003618 TFIIS_cen_dom
     IPR017923 TFIIS_N
     IPR017890 TFS2M

    Graphical View of Domain Structure for InterPro Entry P23193

    ProtoNet protein and cluster: P23193

    1 Blocks protein domain: IPB003617 Transcription elongation factor S-II

    UniProtKB/Swiss-Prot: TCEA1_HUMAN, P23193
    Similarity: Belongs to the TFS-II family
    Similarity: Contains 1 TFIIS central domain
    Similarity: Contains 1 TFIIS N-terminal domain
    Similarity: Contains 1 TFIIS-type zinc finger


    TCEA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCEA1_HUMAN, P23193
    Function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting
    sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases
    that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the
    resumption of elongation from the new 3'-terminus

         Genatlas biochemistry entry for TCEA1:
    transcription elongation factor A for RNA polymerase II,SII class,widely expressed,fused with PLAG1 in
    translocation (3;8)(p21;q12) in salivary tumors (see PSA2)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003746translation elongation factor activity ----
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
         
    TCEA1 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tcea1):
     cardiovascular system  embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism 
     limbs/digits/tail  liver/biliary system  mortality/aging 

    TCEA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tcea1tm1Skmz for TCEA1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TCEA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TCEA1

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    SwitchGear 3'UTR luciferase reporter plasmidTCEA1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TCEA1 About   (see all 7)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript0.78
    Pausing and recovery of HIV elongation0.74
    HIV Transcription Elongation0.78
    Pausing and recovery of Tat-mediated HIV elongation0.73
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.78
    Tat-mediated HIV elongation arrest and recovery0.73
    Formation of HIV elongation complex in the absence of HIV Tat0.76
    RNA Polymerase II Pre-transcription Events0.72
    2HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    3Nucleotide Excision Repair
    Nucleotide Excision Repair0.90
    DNA Repair0.46
    Transcription-coupled NER (TC-NER)0.90
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Assembly of RNA Polymerase-II Initiation Complex
    Transcription of mRNA0.91

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TCEA1
        Transcription of mRNA

    5/25        Reactome Pathways for TCEA1 (see all 25)
        Formation of RNA Pol II elongation complex
    Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    DNA Repair
    Tat-mediated elongation of the HIV-1 transcript



    TCEA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCEA1

    5/136 Interacting proteins for TCEA1 (P231931, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 136)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LEO1Q8WVC01, 3EBI-2608271,EBI-932432 I2D: score=2 
    PAF1Q8N7H51, 3EBI-2608271,EBI-2607770 I2D: score=2 
    ENSG00000206353Q154773I2D: score=1 
    ENSG00000223493Q154773I2D: score=1 
    ENSG00000225737Q154773I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--
    GO:0006283transcription-coupled nucleotide-excision repair TAS--
    GO:0006289nucleotide-excision repair TAS--
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----

    TCEA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCEA1

    Search CenterWatch for drugs/clinical trials and news about TCEA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCEA1 gene (2 alternative transcripts): 
    NM_006756.2  NM_201437.1  

    Unigene Cluster for TCEA1:

    Transcription elongation factor A (SII), 1
    Hs.491745  [show with all ESTs]
    Unigene Representative Sequence: BX538034
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396401(uc003xrv.3) ENST00000521604(uc003xru.3 uc011ldw.2)
    ENST00000521086(uc010lyg.3 uc003xrw.1) ENST00000522635 ENST00000522397
    ENST00000520534 ENST00000518310 ENST00000517351 ENST00000521836 ENST00000518784
    ENST00000519704
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate TCEA1 (see all 17):
    hsa-miR-520d-5p hsa-miR-3653 hsa-miR-500a hsa-miR-340 hsa-miR-183* hsa-miR-320e hsa-miR-362-5p hsa-miR-1286
    SwitchGear 3'UTR luciferase reporter plasmidTCEA1 3' UTR sequence
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    Additional mRNA sequence: 

    AK026617.1 AK290454.1 AK297729.1 AK297957.1 BC072460.1 BT019995.1 BX538034.1 CR542221.1 
    M81601.1 X57198.1 X62585.1 

    24 DOTS entries:

    DT.97816932  DT.448986  DT.100842736  DT.100844938  DT.101984450  DT.102838973  DT.91767047  DT.448985 
    DT.121474916  DT.95257843  DT.120892804  DT.91767043  DT.121474913  DT.91767044  DT.97790547  DT.100035401 
    DT.100645113  DT.100841222  DT.120892737  DT.121474988  DT.121474998  DT.121475008  DT.91767048  DT.95257842 

    24/452 AceView cDNA sequences (see all 452):

    BM696319 BU732534 BM723877 BF970552 BG258151 BQ007977 AI246746 CD677050 
    AI471532 AW316571 BG106440 BU159793 CR604302 AA258187 AL701922 BU684207 
    CA412133 AU279390 CN480630 BM455435 R77738 BM760146 AA306963 AI419671 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCEA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGCACTC
    TCEA1 Expression
    About this image


    See TCEA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCEA1

    SOURCE GeneReport for Unigene cluster: Hs.491745
        SABiosciences Custom PCR Arrays for TCEA1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TCEA1 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcea11 , 5 transcription elongation factor A (SII) 11, 5 92.25(n)1
    96.68(a)1
      1 (1.79 cM)5
    213991  NM_011541.41  NP_035671.11 
     48578145 
    chicken
    (Gallus gallus)
    Aves TCEA11 transcription elongation factor A (SII), 1 82.11(n)
    90(a)
      421119  NM_001006387.1  NP_001006387.1 
    lizard
    (Anolis carolinensis)
    Reptilia TCEA16
    Uncharacterized protein
    87(a)
    1 ↔ 1
    GL343244.1(1154736-1176728)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.2382 Xenopus laevis mRNA for transcriptional factor, complete more 77.27(n)    D82999.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj48e122 wufj48e12 77.97(n)   336105  BC053177.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81173 RNA elongation from Pol II promoter
    transcription more
    49(a)
    (best of 2)
      13E3   --
    worm
    (Caenorhabditis elegans)
    Secernentea T24H10.11 , 3 transcription factor S-II3
    Protein T24H10.11
    48(a)3
    54.66(n)1
    50(a)1
      II(9099286-9100363)3
    1744501  NM_063540.11  NP_495941.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DST11 Dst1p 47.04(n)
    36.88(a)
      852839   NP_011472.1 


    ENSEMBL Gene Tree for TCEA1 (if available)
    TreeFam Gene Tree for TCEA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCEA1 gene
    TCEA32  TCEANC2  TCEA22  
    4 SIMAP similar genes for TCEA1 using alignment to 6 protein entries:     TCEA1_HUMAN (see all proteins):
    TCEA2    TCEA3    MED26    TCEANC

    TCEA1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for TCEA1
    PGOHUM00000236010 PGOHUM00000236460 PGOHUM00000236725


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1109 SNPs in TCEA1 are shown (see all 1109)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs608054501,2
    C,F--54878720(+) ATAGGC/TTGCAG 2 -- ds50012Minor allele frequency- T:0.25WA CSA 4
    rs1465192501,2
    C--54878794(+) ATAAAA/TAAATA 2 -- ds50010--------
    rs1398925831,2
    --54878815(+) GTCTAC/GTATTT 2 -- ds50010--------
    rs1161267991,2
    C--54878849(+) GGTCTC/TTCACA 2 -- ds50010--------
    rs1810151921,2
    --54878854(+) CTCACA/GTTAAA 2 -- ds50010--------
    rs1862190991,2
    --54878886(+) ACTCAC/TGTATT 2 -- ds50010--------
    rs1421769141,2
    --54878905(+) ACCTGC/GCATTC 2 -- ds50010--------
    rs789144221,2
    F--54879034(+) CCTTAG/ATAGTT 2 -- ds50011Minor allele frequency- A:0.05NA 120
    rs1894578881,2
    --54879200(+) AAACAC/TTATTT 2 -- ut310--------
    rs1512647611,2
    --54879263(+) CAAAAC/TAGAGG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for TCEA1 (54879112 - 54935089 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TCEA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2487551CNV Deletion19546169
    essv22151CNV CNV17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601425    OMIM disorders: --

    UniProtKB/Swiss-Prot: TCEA1_HUMAN, P23193
  • Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA)
    [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation
    t(3;8)(p21;q12) with PLAG1

  • 4 diseases for TCEA1:    About MalaCards
    eaf    conjunctivitis    adenoma    hepatitis


    TCEA1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TCEA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cockayne syndrome 70.9 1 11254132 (1)

    Genetic Association Database (GAD): TCEA1

    Export disorders for TCEA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCEA1 gene, integrated from 9 sources (see all 72):
    (articles sorted by number of sources associating them with TCEA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the gene encoding the human transcriptional elongation factor TFIIS. (PubMed id 8112616)1, 2, 3 Park H....Yoo O. (1994)
    2. Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3. (PubMed id 8812434)1, 3, 9 DiMarco S.P....Warren S.T. (1996)
    3. Transcription factor IIS cooperates with the E3 ligas e UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongatio n factor B. (PubMed id 21127351)1, 2 Cojocaru M....Coulombe B. (2011)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Structure of a new nucleic-acid-binding motif in eukaryotic transcriptional elongation factor TFIIS. (PubMed id 7626141)1, 2 Qian X.... Weiss M.A. (1993)
    8. Characterization of a HeLa cDNA clone encoding the human SII protein, an elongation factor for RNA polymerase II. (PubMed id 1378807)1, 2 Chen H.C.... Kane C.M. (1992)
    9. Cloning, expression and characterization of the human transcription elongation factor, TFIIS. (PubMed id 1708494)1, 2 Yoo O.... Agarwal K. (1991)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6917 HGNC: 11612 AceView: TCEA1 Ensembl:ENSG00000187735 euGenes: HUgn6917
    ECgene: TCEA1 H-InvDB: TCEA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCEA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TCEA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCEA1 gene:
    Search GeneIP for patents involving TCEA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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