Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TCEA1 Gene

protein-coding   GIFtS: 57
GCID: GC08M054879

Transcription Elongation Factor A (SII), 1


(Previous symbols: TCEA, GTF2S)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Transcription Elongation Factor A (SII), 11 2     TFIIS2 3
GTF2S1 2 3 5     TF2S2 5
TCEA1 2     SII2
Transcription Elongation Factor S-II Protein 12 3     Transcription Elongation Factor A Protein 12
Transcription Elongation Factor TFIIS.O2 3     

External Ids:    HGNC: 116121   Entrez Gene: 69172   Ensembl: ENSG000001877357   OMIM: 6014255   UniProtKB: P231933   

Export aliases for TCEA1 gene to outside databases

Previous GC identifers: GC03P036581 GC08M054818 GC08M054582 GC08M054929 GC08M055041 GC08M050347


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TCEA1 Gene:
TCEA1 (transcription elongation factor A (SII), 1) is a protein-coding gene. Diseases associated with TCEA1 include eaf, and cockayne syndrome. An important paralog of this gene is TCEA3.

UniProtKB/Swiss-Prot: TCEA1_HUMAN, P23193
Function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting
sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases
that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the
resumption of elongation from the new 3'-terminus

Gene Wiki entry for TCEA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCEA1 gene promoter:
         HFH-3   Pax-2   Pax-2a   HNF-3beta   AREB6   FOXI1   POU2F1   COMP1   HFH-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCEA1 promoter sequence
   Search Chromatin IP Primers for TCEA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCEA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11.2   Ensembl cytogenetic band:  8q11.23   HGNC cytogenetic band: 8q11.2

TCEA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCEA1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M054879:  view genomic region     (about GC identifiers)

Start:
54,879,112 bp from pter      End:
54,935,089 bp from pter
Size:
55,978 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TCEA1_HUMAN, P23193 (See protein sequence)
Recommended Name: Transcription elongation factor A protein 1  
Size: 301 amino acids; 33970 Da
Subunit: Interacts with EAF2 (By similarity). Associates with UBR5 and forms a transcription regulatory complex
made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma
fibrinogen/FGG) by recruiting their promoters
Miscellaneous: S-II binds to RNA-polymerase II in the absence of transcription
2 PDB 3D structures from and Proteopedia for TCEA1:
1TFI (3D)        3NDQ (3D)    
Secondary accessions: A6NF25 A8K339 Q15563 Q6FG87
Alternative splicing: 2 isoforms:  P23193-1   P23193-2   

Explore the universe of human proteins at neXtProt for TCEA1: NX_P23193

Explore proteomics data for TCEA1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys29, Lys67, Lys252
  • Modification sites at PhosphoSitePlus

  • See TCEA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006747.1  NP_958845.1  

    ENSEMBL proteins: 
     ENSP00000395483   ENSP00000428426   ENSP00000429192   ENSP00000428370   ENSP00000428868  
     ENSP00000429182   ENSP00000430450  
    Reactome Protein details: P23193

    TCEA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TCEA1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TCEA1
    GenScript Custom Purified and Recombinant Proteins Services for TCEA1
    Novus Biologicals TCEA1 Proteins
    Novus Biologicals TCEA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TCEA1
    Cloud-Clone Corp. Proteins for TCEA1

    TCEA1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TCEA1
    Novus Biologicals TCEA1 Antibodies
    Abcam antibodies for TCEA1
    Cloud-Clone Corp. Antibodies for TCEA1
    Search ThermoFisher Antibodies for TCEA1
    LSBio Antibodies in human, mouse, rat for TCEA1

    TCEA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TCEA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TCEA1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TCEA1
    Cloud-Clone Corp. CLIAs for TCEA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GTF: General transcription factors

    Selected InterPro protein domains (see all 7):
     IPR003617 TFIIS/CRSP70_N_sub
     IPR001222 Znf_TFIIS
     IPR003618 TFIIS_cen_dom
     IPR017923 TFIIS_N
     IPR017890 TFS2M

    Graphical View of Domain Structure for InterPro Entry P23193

    ProtoNet protein and cluster: P23193

    1 Blocks protein domain: IPB003617 Transcription elongation factor S-II

    UniProtKB/Swiss-Prot: TCEA1_HUMAN, P23193
    Similarity: Belongs to the TFS-II family
    Similarity: Contains 1 TFIIS central domain
    Similarity: Contains 1 TFIIS N-terminal domain
    Similarity: Contains 1 TFIIS-type zinc finger


    TCEA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCEA1_HUMAN, P23193
    Function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting
    sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases
    that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the
    resumption of elongation from the new 3'-terminus

         Genatlas biochemistry entry for TCEA1:
    transcription elongation factor A for RNA polymerase II,SII class,widely expressed,fused with PLAG1 in
    translocation (3;8)(p21;q12) in salivary tumors (see PSA2)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003746translation elongation factor activity ----
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
         
    TCEA1 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tcea1):
     cardiovascular system  embryogenesis  growth/size/body  hematopoietic system  homeostasis/metabolism 
     limbs/digits/tail  liver/biliary system  mortality/aging 

    TCEA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tcea1tm1Skmz for TCEA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCEA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TCEA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCEA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TCEA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TCEA1:
    hsa-mir-155-5p (MIRT020490), hsa-mir-20a-5p (MIRT050483), hsa-mir-497-5p (MIRT041184)

    Block miRNA regulation of human, mouse, rat TCEA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TCEA1 (see all 17):
    hsa-miR-520d-5p hsa-miR-3653 hsa-miR-500a hsa-miR-340 hsa-miR-183* hsa-miR-320e hsa-miR-362-5p hsa-miR-1286
    SwitchGear 3'UTR luciferase reporter plasmidTCEA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TCEA1
    Predesigned siRNA for gene silencing in human, mouse, rat TCEA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TCEA1

    Clone
    Products:
         
    OriGene clones in human, mouse for TCEA1 (see all 11)
    OriGene ORF clones in mouse, rat for TCEA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TCEA1 (NM_006756)
    Sino Biological Human cDNA Clone for TCEA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCEA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEA1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TCEA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TCEA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TCEA1_HUMAN, P23193: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--

    TCEA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TCEA1 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript0.77
    Pausing and recovery of HIV elongation0.73
    HIV Transcription Elongation0.77
    HIV elongation arrest and recovery0.73
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.77
    Pausing and recovery of Tat-mediated HIV elongation0.72
    RNA Polymerase II Transcription Elongation0.75
    Tat-mediated HIV elongation arrest and recovery0.72
    2DNA Repair
    Transcription-coupled NER (TC-NER)0.90
    Dual incision reaction in TC-NER0.65
    Nucleotide Excision Repair0.90
    DNA Repair0.45
    Formation of transcription-coupled NER (TC-NER) repair complex0.65
    3HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    4Assembly of RNA Polymerase-II Initiation Complex
    Transcription of mRNA0.91
    5Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TCEA1
        Transcription of mRNA


    Selected Reactome Pathways for TCEA1 (see all 12)
        Pausing and recovery of Tat-mediated HIV elongation
    Formation of RNA Pol II elongation complex
    Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    Pausing and recovery of HIV elongation



    TCEA1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCEA1
    Interactions:

        GeneGlobe Interaction Network for TCEA1

    Selected Interacting proteins for TCEA1 (P231931, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 135)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LEO1Q8WVC01, 3EBI-2608271,EBI-932432 I2D: score=2 
    PAF1Q8N7H51, 3EBI-2608271,EBI-2607770 I2D: score=2 
    ENSG00000206353Q154773I2D: score=1 
    ENSG00000223493Q154773I2D: score=1 
    ENSG00000225737Q154773I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--
    GO:0006283transcription-coupled nucleotide-excision repair TAS--
    GO:0006289nucleotide-excision repair TAS--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----

    TCEA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCEA1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TCEA1 gene (2 alternative transcripts): 
    NM_006756.3  NM_201437.2  

    Unigene Cluster for TCEA1:

    Transcription elongation factor A (SII), 1
    Hs.491745  [show with all ESTs]
    Unigene Representative Sequence: BX538034
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396401(uc003xrv.3) ENST00000521604(uc003xru.3 uc011ldw.2)
    ENST00000521086(uc010lyg.3 uc003xrw.1) ENST00000522635 ENST00000522397
    ENST00000520534 ENST00000518310 ENST00000517351 ENST00000521836 ENST00000518784
    ENST00000519704
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TCEA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TCEA1 (see all 17):
    hsa-miR-520d-5p hsa-miR-3653 hsa-miR-500a hsa-miR-340 hsa-miR-183* hsa-miR-320e hsa-miR-362-5p hsa-miR-1286
    SwitchGear 3'UTR luciferase reporter plasmidTCEA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TCEA1
    Predesigned siRNA for gene silencing in human, mouse, rat TCEA1
    Clone
    Products:
         
    OriGene clones in human, mouse for TCEA1 (see all 11)
    OriGene ORF clones in mouse, rat for TCEA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TCEA1 (NM_006756)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCEA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEA1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TCEA1
    OriGene qSTAR qPCR primer pairs in human, mouse for TCEA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TCEA1
      QuantiTect SYBR Green Assays in human, mouse, rat TCEA1
      QuantiFast Probe-based Assays in human, mouse, rat TCEA1

    Additional mRNA sequence: 

    AK026617.1 AK290454.1 AK297729.1 AK297957.1 BC072460.1 BT019995.1 BX538034.1 CR542221.1 
    M81601.1 X57198.1 X62585.1 

    24 DOTS entries:

    DT.97816932  DT.448986  DT.100842736  DT.100844938  DT.101984450  DT.102838973  DT.91767047  DT.448985 
    DT.121474916  DT.95257843  DT.120892804  DT.91767043  DT.121474913  DT.91767044  DT.97790547  DT.100035401 
    DT.100645113  DT.100841222  DT.120892737  DT.121474988  DT.121474998  DT.121475008  DT.91767048  DT.95257842 

    Selected AceView cDNA sequences (see all 452):

    BM985200 BF593762 BQ898965 CD677050 AA897040 BQ016366 NM_201437 BM803914 
    AA862764 CA447214 BG286343 F01513 AA306963 AU279390 BU159793 AI631009 
    CR604302 R77738 AL701922 BF970552 CA412133 NM_006756 BU629347 BU156723 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TCEA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGCACTC
    TCEA1 Expression
    About this image

    TCEA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCEA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.491745
        Custom PCR Arrays for TCEA1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TCEA1
    OriGene qSTAR qPCR primer pairs in human, mouse for TCEA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TCEA1
    QuantiTect SYBR Green Assays in human, mouse, rat TCEA1
    QuantiFast Probe-based Assays in human, mouse, rat TCEA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TCEA1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcea11 , 5 transcription elongation factor A (SII) 11, 5 92(n)1
    97(a)1
      1 (1.79 cM)5
    213991  NM_001159750.11  NP_001153222.11 
     48578145 
    chicken
    (Gallus gallus)
    Aves TCEA11 transcription elongation factor A (SII), 1 82.11(n)
    90(a)
      421119  NM_001006387.1  NP_001006387.1 
    lizard
    (Anolis carolinensis)
    Reptilia TCEA16
    transcription elongation factor A (SII), 1
    87(a)
    1 ↔ 1
    GL343244.1(1154736-1176728)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.2382 Xenopus laevis mRNA for transcriptional factor, complete more 77.27(n)    D82999.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj48e122 wufj48e12 77.97(n)   336105  BC053177.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81173 RNA elongation from Pol II promoter
    transcription more
    49(a)
    (best of 2)
      13E3   --
    worm
    (Caenorhabditis elegans)
    Secernentea T24H10.11 , 3 transcription factor S-II3
    T24H10.11
    48(a)3
    55.51(n)1
    51.67(a)1
      II(9099286-9100363)3
    1744501  NM_063540.11  NP_495941.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DST16
    General transcription elongation factor TFIIS, ena...
    28(a)
    1 → many
    VII(417483-418412) YGL043W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TFIIS1 TFIIS 52.93(n)
    40(a)
      818438  NM_129413.3  NP_181390.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g02297001 Os07g0229700 45.91(n)
    37.36(a)
      4342769  NM_001065762.1  NP_001059227.1 


    ENSEMBL Gene Tree for TCEA1 (if available)
    TreeFam Gene Tree for TCEA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TCEA1 gene
    TCEA32  TCEANC2  TCEA22  
    4 SIMAP similar genes for TCEA1 using alignment to 6 protein entries:     TCEA1_HUMAN (see all proteins):
    TCEA3    TCEA2    MED26    TCEANC

    TCEA1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for TCEA1
    PGOHUM00000236010 PGOHUM00000236460 PGOHUM00000236725


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TCEA1 (see all 1109)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs608054501,2
    C,F--54878720(+) ATAGGC/TTGCAG 2 -- ds50012Minor allele frequency- T:0.25WA CSA 4
    rs1465192501,2
    C--54878794(+) ATAAAA/TAAATA 2 -- ds50010--------
    rs1398925831,2
    --54878815(+) GTCTAC/GTATTT 2 -- ds50010--------
    rs1161267991,2
    C--54878849(+) GGTCTC/TTCACA 2 -- ds50010--------
    rs1810151921,2
    --54878854(+) CTCACA/GTTAAA 2 -- ds50010--------
    rs1862190991,2
    --54878886(+) ACTCAC/TGTATT 2 -- ds50010--------
    rs1421769141,2
    --54878905(+) ACCTGC/GCATTC 2 -- ds50010--------
    rs789144221,2
    F--54879034(+) CCTTAG/ATAGTT 2 -- ds50011Minor allele frequency- A:0.05NA 120
    rs1894578881,2
    --54879200(+) AAACAC/TTATTT 2 -- ut310--------
    rs1512647611,2
    --54879263(+) CAAAAC/TAGAGG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for TCEA1 (54879112 - 54935089 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TCEA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2487551CNV Deletion19546169
    essv22151CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCEA1
    DNA2.0 Custom Variant and Variant Library Synthesis for TCEA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601425    OMIM disorders: --

    UniProtKB/Swiss-Prot: TCEA1_HUMAN, P23193
  • Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA)
    [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation
    t(3;8)(p21;q12) with PLAG1

  • 8 diseases for TCEA1:    
    About MalaCards
    eaf    cockayne syndrome    conjunctivitis    hiv-1
    adenoma    multiple myeloma    myeloma    hepatitis


    TCEA1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TCEA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cockayne syndrome 70.9 1 11254132 (1)

    Genetic Association Database (GAD): TCEA1

    Export disorders for TCEA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TCEA1 gene, integrated from 10 sources (see all 73):
    (articles sorted by number of sources associating them with TCEA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the gene encoding the human transcriptional elongation factor TFIIS. (PubMed id 8112616)1, 2, 3 Park H.R.... Yoo O. (Gene 1994)
    2. Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --&gt; p21.3. (PubMed id 8812434)1, 3, 9 DiMarco S.P....Warren S.T. (Genomics 1996)
    3. Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B. (PubMed id 21127351)1, 2 Cojocaru M.... Coulombe B. (J. Biol. Chem. 2011)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Structure of a new nucleic-acid-binding motif in eukaryotic transcriptional elongation factor TFIIS. (PubMed id 7626141)1, 2 Qian X.... Weiss M.A. (Nature 1993)
    8. Characterization of a HeLa cDNA clone encoding the human SII protein, an elongation factor for RNA polymerase II. (PubMed id 1378807)1, 2 Chen H.C.... Kane C.M. (Gene 1992)
    9. Cloning, expression and characterization of the human transcription elongation factor, TFIIS. (PubMed id 1708494)1, 2 Yoo O.... Agarwal K. (Nucleic Acids Res. 1991)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6917 HGNC: 11612 AceView: TCEA1 Ensembl:ENSG00000187735 euGenes: HUgn6917
    ECgene: TCEA1 H-InvDB: TCEA1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TCEA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TCEA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TCEA1 gene:
    Search GeneIP for patents involving TCEA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TCEA1  
     OriGene qPCR primer pairs and template standards for TCEA1   OriGene Protein Over-expression Lysate for TCEA1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TCEA1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TCEA1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TCEA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TCEA1   OriGene Custom Protein Services for TCEA1  

     
     
     Block miRNA regulation of human, mouse, rat TCEA1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TCEA1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCEA1 Predesigned siRNA for gene silencing in human, mouse, rat TCEA1
     QuantiFast Probe-based Assays in human, mouse, rat TCEA1 QuantiTect SYBR Green Assays in human, mouse, rat TCEA1
     Custom PCR Arrays for TCEA1 Search Chromatin IP Primers for TCEA1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TCEA1  GeneGlobe Interaction Network for TCEA1
     Regulatory tfbs in TCEA1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TCEA1 GenScript cDNA clones with any tag delivered in your preferred vector for TCEA1
     GenScript Custom Assay Services for TCEA1 GenScript Custom overexpressing Cell Line Services for TCEA1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TCEA1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TCEA1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TCEA1 antibodies
     TCEA1 proteins
     TCEA1 lysates
     Antibodies for TCEA1
     See all of Abcam's Antibodies, Kits and Proteins for TCEA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TCEA1
     Proteins for TCEA1
     Antibodies for TCEA1
     ELISAs for TCEA1
     CLIAs for TCEA1



     Browse ESI BIO Cell Lines and PureStem Progenitors for TCEA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCEA1
     SwitchGear 3'UTR luciferase reporter plasmids for TCEA1
     SwitchGear Promoter luciferase reporter plasmids for TCEA1
     Search ThermoFisher Antibodies for TCEA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCEA1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCEA1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TCEA1
     LSBio Antibodies in human, mouse, rat for TCEA1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TCEA1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4