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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TCAIM Gene

protein-coding GIFtS: 37
GCID: GC03P044379

T cell activation inhibitor, mitochondrial

(Previous name: chromosome 3 open reading frame 23 )
(Previous symbol: C3orf23)

Search for TCAIM
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
T Cell Activation Inhibitor, Mitochondrial¹ ²		TOAG1² ³
C3orf23¹ ² ³		DKFZp313N0621¹
TOAG-1¹ ² ³		Chromosome 3 Open Reading Frame 23¹
Tolerance Associated Gene-1 Protein² ³		T-Cell Activation Inhibitor, Mitochondrial²

External Ids:	HGNC: 25241¹	Entrez Gene: 285343²	Ensembl: ENSG00000179152⁷	UniProtKB: Q8N3R3³

Export aliases for TCAIM gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TCAIM_HUMAN, Q8N3R3

Function: May regulate T-cell apoptosis (By similarity)

Gene Wiki entry for TCAIM (C3orf23)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for TCAIM
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TCAIM promoter sequence

Search SABiosciences Chromatin IP Primers for TCAIM

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCAIM

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.33-p21.32

TCAIM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCAIM gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P044379: view genomic region (about GC identifiers)

Start:	44,379,611 bp from pter	End:	44,450,943 bp from pter
Size:	71,333 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TCAIM_HUMAN, Q8N3R3 (See protein sequence)

Recommended Name: T-cell activation inhibitor, mitochondrial

Size: 496 amino acids; 57925 Da

Subcellular location: Mitochondrion (By similarity)

Secondary accessions: A8K9P1 Q0P5T9 Q495R1 Q495R3 Q4G0M4 Q6GMU8

Alternative splicing: 4 isoforms: Q8N3R3-1 Q8N3R3-2 Q8N3R3-3 Q8N3R3-4 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TCAIM: NX_Q8N3R3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N3R3

TCAIM Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001025010.1 NP_001025011.1 NP_776187.2

ENSEMBL proteins:

ENSP00000373252 ENSP00000402581 ENSP00000379388 ENSP00000341539 ENSP00000392032

ENSP00000387842 ENSP00000402604

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	Uscn Proteins for TCAIM

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	--

TCAIM for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8N3R3

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TCAIM_HUMAN, Q8N3R3

Function: May regulate T-cell apoptosis (By similarity)

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCAIM

1 GenomeRNAi human phenotype for TCAIM:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TCAIM

4 Interacting proteins for TCAIM (Q8N3R3³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EBF1	Q9UH73³	I2D: score=3
EBF3	Q9H4W6³	I2D: score=3
SIN3A	Q96ST3³	I2D: score=2
MAPK6	Q16659³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TCAIM
Search CenterWatch for drugs/clinical trials and news about TCAIM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TCAIM gene (3 alternative transcripts):

NM_001029839.2 NM_001029840.2 NM_173826.3

Unigene Cluster for TCAIM:

T cell activation inhibitor, mitochondrial

Hs.55131 [show with all ESTs]

Unigene Representative Sequence: NM_173826

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000383746(uc003cnb.4) ENST00000417237 ENST00000494638 ENST00000396078(uc003cnc.4)

ENST00000342649(uc010him.3 uc003cnd.4 uc003cne.4) ENST00000462230

ENST00000412611 ENST00000444602 ENST00000431657 ENST00000462612 ENST00000417768

ENST00000469246

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Additional cDNA sequence:

AK056593.1 AK123680.1 AK124087.1 AK292756.1 AL832473.1 AL833118.1 BC009400.2 BC038420.1

BC047231.1 BC062587.1 BC073829.1 BC101059.2 BC101060.2 BC101061.2

13 DOTS entries:

DT.446526 DT.311281 DT.100788702 DT.100788700 DT.70102750 DT.100760498 DT.311282 DT.95139788

DT.100788699 DT.120905086 DT.95185195 DT.100683400 DT.92062583

24/202 AceView cDNA sequences (see all 202):

BX488271 T39891 BC073829 BC047231 BM763626 BM970568 AI248643 BU189734

BF940256 R77698 AA639405 AI167901 AI215014 BF224329 AA295205 CB410866

CA446446 AA313786 AA978051 CB132893 BQ014251 AI805653 CK905805 BX381695

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TCAIM (see all 14) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	·	10c	·	10d	·	10e	·	10f	^	11	^	12	^	13	^	14a	·	14b	^	15a	·
SP1:													-						-		-		-				-		-												-
SP2:													-						-		-		-				-														-
SP3:													-						-		-		-				-		-
SP4:																			-		-		-				-		-												-
SP5:													-						-				-				-

ExUns:	15b	^	16	^	17a	·	17b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TCAIM

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

See TCAIM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCAIM

SOURCE GeneReport for Unigene cluster: Hs.55131

SABiosciences Custom PCR Arrays for TCAIM

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TCAIM gene from 7/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tcaim⁵ D9Ertd402e¹	DNA segment, Chr 9, ERATO Doi 402, expressed^{1, 5}	82.53(n)¹ 82.86(a)¹		9 (73.14 cM)⁵ 382117¹ NM_001013405.2¹ NP_001013423.2¹ 122805539⁵
chicken (Gallus gallus)	Aves	C2H3orf23¹	chromosome 2 open reading frame, human C3orf23	75.32(n) 76.07(a)		420670 XM_418769.3 XP_418769.2
lizard (Anolis carolinensis)	Reptilia	C3orf23⁶	--	72(a)	1 ↔ 1	1(193285731-193305564)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.18228²	Transcribed sequence with weak similarity to protein more	76.08(n)		AL971925.2
zebrafish (Danio rerio)	Actinopterygii	LOC559258¹	uncharacterized protein C3orf23-like	58.73(n) 59.09(a)		559258 XM_682578.2 XP_687670.2
fruit fly (Drosophila melanogaster)	Insecta	CG13295¹	CG13295	43.66(n) 33.63(a)		38692 NM_139764.2 NP_648021.1
worm (Caenorhabditis elegans)	Secernentea	C35B8.3¹	Protein C35B8.3	40(n) 27.36(a)		181152 NM_001029271.1 NP_001024442.1

ENSEMBL Gene Tree for TCAIM (if available)
TreeFam Gene Tree for TCAIM (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187223647^1,2		--	44377646(+)	`ACTGAA/GGTAGA`	1	--	us2k¹		0	--	--	--	--
rs115481429^1,2	C,	--	44377768(+)	`AACAGA/GGCTAA`	1	--	us2k¹		0	--	--	--	--
rs146514572^1,2		--	44377943(+)	`ATTATC/TTGTTG`	1	--	us2k¹		0	--	--	--	--
rs11707582^1,2	C,F,A,H,	--	44377959(+)	`CCACAA/GTCAGA`	3	--	us2k¹		19		NS EA NA CSA WA	2205
rs140561261^1,2		--	44377975(+)	`CCTGGC/GATCAT`	3	--	us2k¹		0	--	--	--	--
rs145641664^1,2		--	44377982(+)	`TCATCC/TACAGA`	3	--	us2k¹		0	--	--	--	--
rs138181970^1,2		--	44378106(+)	`CTCTCA/GCCCTC`	3	--	us2k¹		0	--	--	--	--
rs141000156^1,2		--	44378123(+)	`ACCCTC/TGTTCT`	3	--	us2k¹		0	--	--	--	--
rs185388417^1,2		--	44378129(+)	`GTTCTA/GCAGGA`	3	--	us2k¹		0	--	--	--	--
rs189921643^1,2		--	44378199(+)	`CCCCCC/TCTTCA`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TCAIM (44379611 - 44450943 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TCAIM: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCAIM

DNA2.0 Custom Variant and Variant Library Synthesis for TCAIM

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TCAIM gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with TCAIM)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
Expression of tolerance associated gene-1, a mitochon drial protein inhibiting T cell activation, can be used to predict response to immune modulating therapies. (PubMed id 19684086)¹ Keeren K....Sawitzki B. (2009)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)¹ Wiemann S.... Poustka A. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 285343	HGNC: 25241	AceView: DKFZp313N0621	Ensembl:ENSG00000179152	euGenes: HUgn285343
ECgene: TCAIM	H-InvDB: TCAIM

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TCAIM	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TCAIM gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TCAIM gene:
Search GeneIP for patents involving TCAIM

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCAIM		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCAIM
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCAIM
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCAIM
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCAIM
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCAIM
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	GenScript Custom Purified and Recombinant Proteins Services for TCAIM		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TCAIM
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	GenScript Custom overexpressing Cell Line Services for TCAIM		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCAIM

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ThermoFisher Antibodies for TCAIM

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCAIM

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TCAIM gene at Home site.

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TCAIM Gene

T cell activation inhibitor, mitochondrial

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TCAIM Gene

T cell activation inhibitor, mitochondrial

Aliasesfor TCAIM gene

Summariesfor TCAIM gene

Genomic Viewsfor TCAIM gene

Proteinsfor TCAIM gene

Protein Domains /Familiesfor TCAIM gene

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