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Aliases for TCAIM Gene

Aliases for TCAIM Gene

  • T-Cell Activation Inhibitor, Mitochondrial 2 3 5
  • Tolerance Associated Gene-1 Protein 3 4
  • C3orf23 3 4
  • TOAG-1 3 4
  • TOAG1 3 4
  • T Cell Activation Inhibitor, Mitochondrial 2
  • Chromosome 3 Open Reading Frame 23 2
  • Tolerance Associated Gene-1 2

External Ids for TCAIM Gene

Previous HGNC Symbols for TCAIM Gene

  • C3orf23

Summaries for TCAIM Gene

GeneCards Summary for TCAIM Gene

TCAIM (T-Cell Activation Inhibitor, Mitochondrial) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TCAIM Gene

  • May regulate T-cell apoptosis.

Gene Wiki entry for TCAIM Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCAIM Gene

Genomics for TCAIM Gene

Regulatory Elements for TCAIM Gene

Enhancers for TCAIM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G044233 1.3 Ensembl ENCODE 7.8 -102.2 -102217 5.6 PKNOX1 ATF1 ARNT BRCA1 TCF12 ELK1 GATA2 ZNF143 FOS CAVIN1 ZNF660 RNU6-367P MIR138-1 ZNF197 TCAIM ENSG00000271941 TOPAZ1 PIR53341
GH03G044031 1 FANTOM5 ENCODE 4.2 -305.5 -305475 1.9 PKNOX1 MTA2 BHLHE40 TEAD4 GATAD2B EBF1 TBX21 JUND EED IKZF1 RNU6-367P ENSG00000261786 SNRK TCAIM GC03M044031
GH03G044202 0.9 ENCODE dbSUPER 4.2 -132.3 -132333 5.7 CBX3 ZNF133 HLF NFIC ZNF316 KLF16 ZBTB33 TRIM24 NFE2 TRIM28 ZNF660 ZNF197 ENSG00000271941 TCAIM TOPAZ1 PIR53341
GH03G044201 0.5 ENCODE dbSUPER 6.8 -136.1 -136133 1.2 ZNF197 ZNF660 TCAIM TOPAZ1 PIR53341
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCAIM on UCSC Golden Path with GeneCards custom track

Promoters for TCAIM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151573 581 2201 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Location for TCAIM Gene

Chromosome:
3
Start:
44,338,119 bp from pter
End:
44,409,451 bp from pter
Size:
71,333 bases
Orientation:
Plus strand

Genomic View for TCAIM Gene

Genes around TCAIM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCAIM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCAIM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCAIM Gene

Proteins for TCAIM Gene

  • Protein details for TCAIM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3R3-TCAIM_HUMAN
    Recommended name:
    T-cell activation inhibitor, mitochondrial
    Protein Accession:
    Q8N3R3
    Secondary Accessions:
    • A8K9P1
    • Q0P5T9
    • Q495R1
    • Q495R3
    • Q4G0M4
    • Q6GMU8

    Protein attributes for TCAIM Gene

    Size:
    496 amino acids
    Molecular mass:
    57925 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCAIM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCAIM Gene

Post-translational modifications for TCAIM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCAIM Gene

Domains & Families for TCAIM Gene

Protein Domains for TCAIM Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TCAIM: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TCAIM Gene

Function for TCAIM Gene

Molecular function for TCAIM Gene

UniProtKB/Swiss-Prot Function:
May regulate T-cell apoptosis.
genes like me logo Genes that share phenotypes with TCAIM: view

Animal Models for TCAIM Gene

MGI Knock Outs for TCAIM:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCAIM Gene

Localization for TCAIM Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCAIM Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCAIM gene
Compartment Confidence
mitochondrion 5
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TCAIM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with TCAIM: view

Pathways & Interactions for TCAIM Gene

SuperPathways for TCAIM Gene

No Data Available

Interacting Proteins for TCAIM Gene

Gene Ontology (GO) - Biological Process for TCAIM Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCAIM Gene

Drugs & Compounds for TCAIM Gene

No Compound Related Data Available

Transcripts for TCAIM Gene

Unigene Clusters for TCAIM Gene

T cell activation inhibitor, mitochondrial:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCAIM Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - -
SP9: - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - - -
SP13: -
SP14: -

ExUns: 15b ^ 16 ^ 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for TCAIM Gene

GeneLoc Exon Structure for
TCAIM
ECgene alternative splicing isoforms for
TCAIM

Expression for TCAIM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCAIM Gene

NURSA nuclear receptor signaling pathways regulating expression of TCAIM Gene:

TCAIM

SOURCE GeneReport for Unigene cluster for TCAIM Gene:

Hs.55131

Evidence on tissue expression from TISSUES for TCAIM Gene

  • Nervous system(4.6)
  • Blood(4.2)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with TCAIM: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCAIM Gene

Orthologs for TCAIM Gene

This gene was present in the common ancestor of animals.

Orthologs for TCAIM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCAIM 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia TCAIM 34 35
  • 92.14 (n)
cow
(Bos Taurus)
Mammalia TCAIM 34 35
  • 89.81 (n)
rat
(Rattus norvegicus)
Mammalia Tcaim 34
  • 83 (n)
mouse
(Mus musculus)
Mammalia Tcaim 34 16 35
  • 82.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TCAIM 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCAIM 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H3ORF23 34
  • 75.32 (n)
TCAIM 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCAIM 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcaim 34
  • 67.9 (n)
Str.18228 34
zebrafish
(Danio rerio)
Actinopterygii LOC559258 34
  • 58.6 (n)
TCAIM 35
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13295 34 35
  • 44.25 (n)
CG2854 35
  • 23 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009133 34
  • 41.08 (n)
worm
(Caenorhabditis elegans)
Secernentea C35B8.3 34 35
  • 41.53 (n)
Species where no ortholog for TCAIM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCAIM Gene

ENSEMBL:
Gene Tree for TCAIM (if available)
TreeFam:
Gene Tree for TCAIM (if available)

Paralogs for TCAIM Gene

No data available for Paralogs for TCAIM Gene

Variants for TCAIM Gene

Sequence variations from dbSNP and Humsavar for TCAIM Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000085646 -- 44,356,921(+) GCATG(A/C)AGTGA intron-variant
rs1000102677 -- 44,351,077(+) GGCTC(A/G)CTGCA intron-variant
rs1000137924 -- 44,356,648(+) ACTCC(C/G)AGGTG intron-variant
rs1000140133 -- 44,377,915(+) AAAGC(A/C)ATTCC intron-variant
rs1000170770 -- 44,356,298(+) GAGGC(A/G)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCAIM Gene

Variant ID Type Subtype PubMed ID
dgv282n21 CNV loss 19592680
dgv859e199 CNV deletion 23128226
esv1002255 CNV deletion 20482838
esv2422854 CNV deletion 19546169
esv3596033 CNV loss 21293372
nsv528038 CNV gain 19592680
nsv954475 CNV duplication 24416366

Variation tolerance for TCAIM Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCAIM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCAIM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCAIM Gene

Disorders for TCAIM Gene

Relevant External Links for TCAIM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCAIM

No disorders were found for TCAIM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCAIM Gene

Publications for TCAIM Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. B-cell-related biomarkers of tolerance are up-regulated in rejection-free kidney transplant recipients. (PMID: 23222918) Viklicky O. … Reinke P. (Transplantation 2013) 3 64
  5. Expansion of memory-type CD8+ T cells correlates with the failure of early immunosuppression withdrawal after cadaver liver transplantation using high-dose ATG induction and rapamycin. (PMID: 23799424) Donckier V. … Goldman M. (Transplantation 2013) 3 64

Products for TCAIM Gene

Sources for TCAIM Gene

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