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Aliases for TCAF2 Gene

Aliases for TCAF2 Gene

  • TRPM8 Channel-Associated Factor 2 2 3
  • Family With Sequence Similarity 139, Member A 2 3
  • Family With Sequence Similarity 115, Member C 2 3
  • TRP Channel-Associated Factor 2 3 4
  • FAM115C 3 4
  • FAM139A 3 4
  • Protein FAM115C 3

External Ids for TCAF2 Gene

Previous Symbols for TCAF2 Gene

  • FAM139A
  • FAM115C

Summaries for TCAF2 Gene

GeneCards Summary for TCAF2 Gene

TCAF2 (TRPM8 Channel-Associated Factor 2) is a Protein Coding gene. An important paralog of this gene is TCAF1.

UniProtKB/Swiss-Prot for TCAF2 Gene

  • Isoform 2: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCAF2 Gene

Genomics for TCAF2 Gene

Genomic Location for TCAF2 Gene

Start:
143,620,950 bp from pter
End:
143,730,409 bp from pter
Size:
109,460 bases
Orientation:
Plus strand

Genomic View for TCAF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCAF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCAF2 Gene

No data available for Regulatory Elements for TCAF2 Gene

Proteins for TCAF2 Gene

  • Protein details for TCAF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFQ2-TCAF2_HUMAN
    Recommended name:
    TRPM8 channel-associated factor 2
    Protein Accession:
    A6NFQ2
    Secondary Accessions:
    • B4DK02
    • Q14D25
    • Q17RQ4
    • Q8IWQ0
    • Q8NF84

    Protein attributes for TCAF2 Gene

    Size:
    919 amino acids
    Molecular mass:
    100906 Da
    Quaternary structure:
    • Isoform 2 interacts with TRPM8 (via N-terminus and C-terminus domains); the interaction inhibits TRPM8 channel activity. Interacts with TRPV6.
    SequenceCaution:
    • Sequence=BAC03376.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TCAF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCAF2 Gene

Proteomics data for TCAF2 Gene at MOPED

Post-translational modifications for TCAF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCAF2 Gene

Domains for TCAF2 Gene

Protein Domains for TCAF2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A6NFQ2

UniProtKB/Swiss-Prot:

TCAF2_HUMAN
Domain:
  • Contains 1 peptidase M60 domain.:
    • A6NFQ2
Family:
  • Belongs to the TCAF family.:
    • A6NFQ2
genes like me logo Genes that share domains with TCAF2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TCAF2 Gene

Function for TCAF2 Gene

Molecular function for TCAF2 Gene

UniProtKB/Swiss-Prot Function: Isoform 2: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner.

Gene Ontology (GO) - Molecular Function for TCAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044325 ion channel binding IPI 25559186
genes like me logo Genes that share ontologies with TCAF2: view

Phenotypes for TCAF2 Gene

GenomeRNAi human phenotypes for TCAF2:
genes like me logo Genes that share phenotypes with TCAF2: view

miRNA for TCAF2 Gene

miRTarBase miRNAs that target TCAF2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TCAF2 Gene

Localization for TCAF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCAF2 Gene

Isoform 2: Cell membrane. Note=Colocalizes with TRPM8 on the plasma membrane. {ECO:0000269 PubMed:25559186}.

Gene Ontology (GO) - Cellular Components for TCAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 25559186
genes like me logo Genes that share ontologies with TCAF2: view

No data available for Subcellular locations from COMPARTMENTS for TCAF2 Gene

Pathways for TCAF2 Gene

SuperPathways for TCAF2 Gene

No Data Available

Interacting Proteins for TCAF2 Gene

Gene Ontology (GO) - Biological Process for TCAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006810 transport IEA --
GO:0010360 negative regulation of anion channel activity IDA 25559186
GO:0030335 positive regulation of cell migration IDA 25559186
GO:0090314 positive regulation of protein targeting to membrane IMP 25559186
genes like me logo Genes that share ontologies with TCAF2: view

No data available for Pathways by source for TCAF2 Gene

Transcripts for TCAF2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TCAF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c
SP1: -
SP2: -
SP3:

Relevant External Links for TCAF2 Gene

GeneLoc Exon Structure for
TCAF2
ECgene alternative splicing isoforms for
TCAF2

Expression for TCAF2 Gene

mRNA expression in normal human tissues for TCAF2 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TCAF2 Gene

mRNA Expression by UniProt/SwissProt for TCAF2 Gene

A6NFQ2-TCAF2_HUMAN
Tissue specificity: Isoform 2 is expressed in the prostate and in cancerous prostate samples.
genes like me logo Genes that share expressions with TCAF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TCAF2 Gene

Orthologs for TCAF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCAF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM115C 35
  • 98.82 (n)
  • 98.22 (a)
FAM115C 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM115C 35
  • 82.03 (n)
  • 79.59 (a)
FAM115C 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM115C 35
  • 83.33 (n)
  • 80.74 (a)
FAM115C 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam115c 35
  • 79.27 (n)
  • 76.12 (a)
Fam115c 16
Fam115c 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 41 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.1616 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fam115c 35
  • 54.59 (n)
  • 50.13 (a)
Str.16417 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-210b2.2 36
  • 36 (a)
ManyToMany
si:ch211-210b2.3 36
  • 36 (a)
ManyToMany
si:ch211-210b2.4 36
  • 36 (a)
ManyToMany
zgc:162193 35
  • 49.82 (n)
  • 41.39 (a)
zgc:162193 36
  • 37 (a)
ManyToMany
Species with no ortholog for TCAF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCAF2 Gene

ENSEMBL:
Gene Tree for TCAF2 (if available)
TreeFam:
Gene Tree for TCAF2 (if available)

Paralogs for TCAF2 Gene

Paralogs for TCAF2 Gene

genes like me logo Genes that share paralogs with TCAF2: view

Variants for TCAF2 Gene

Sequence variations from dbSNP and Humsavar for TCAF2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1568852 -- 143,703,208(-) GCCAG(C/T)ATGCG reference, missense
rs2049455 -- 143,708,237(+) TGAGG(A/C)CAGCC intron-variant
rs2049456 -- 143,711,749(+) ATGAA(C/T)ACACA intron-variant
rs2242486 -- 143,726,988(-) AATAC(C/T)ATACT intron-variant
rs2306872 -- 143,720,495(+) GAGCC(A/G)GGAAA missense, reference

Relevant External Links for TCAF2 Gene

HapMap Linkage Disequilibrium report
TCAF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCAF2 Gene

Disorders for TCAF2 Gene

No disorders were found for TCAF2 Gene.

No data available for UniProtKB/Swiss-Prot for TCAF2 Gene

Publications for TCAF2 Gene

  1. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. (PMID: 25559186) Gkika D. … Prevarskaya N. (J. Cell Biol. 2015) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 4
  5. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H. … Ohara O. (DNA Res. 2003) 4

Products for TCAF2 Gene

Sources for TCAF2 Gene

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