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Aliases for TCAF2 Gene

Aliases for TCAF2 Gene

  • TRPM8 Channel Associated Factor 2 2 3 5
  • Family With Sequence Similarity 139, Member A 2 3
  • Family With Sequence Similarity 115, Member C 2 3
  • TRPM8 Channel-Associated Factor 2 2 3
  • TRP Channel-Associated Factor 2 3 4
  • FAM115C 3 4
  • FAM139A 3 4
  • Protein FAM115C 3
  • GATD9 3

External Ids for TCAF2 Gene

Previous HGNC Symbols for TCAF2 Gene

  • FAM139A
  • FAM115C

Previous GeneCards Identifiers for TCAF2 Gene

  • GC07P143621
  • GC07P143622

Summaries for TCAF2 Gene

GeneCards Summary for TCAF2 Gene

TCAF2 (TRPM8 Channel Associated Factor 2) is a Protein Coding gene. GO annotations related to this gene include ion channel binding. An important paralog of this gene is LOC100533814.

UniProtKB/Swiss-Prot for TCAF2 Gene

  • Isoform 2: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner.

Additional gene information for TCAF2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCAF2 Gene

Genomics for TCAF2 Gene

Regulatory Elements for TCAF2 Gene

Enhancers for TCAF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H143262 1.1 ENCODE 13.7 -356.8 -356838 2.8 HDGF ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF143 LOC154761 TCAF2 CASP2 GSTK1 TMEM139
GH07H143244 1 FANTOM5 Ensembl ENCODE 10.2 -375.7 -375655 1.3 MCM7 PRDM6 ZNF266 CASP2 RN7SL535P FAM131B TMEM139 LOC105375545 LOC154761 LOC100507507 ZYX TCAF2 OR9A2
GH07H143405 0.6 ENCODE 10 -214.7 -214710 2.2 TCF12 MCM7 MCM3 POLR2A IKZF1 MCM5 FOS PRDM10 CASP2 LOC154761 EPHA1-AS1 OR2A1 TCAF2 RN7SL535P EPHA1 MIR6892
GH07H143120 0.5 ENCODE 4.7 -500.1 -500106 1.3 PKNOX1 GATA3 JUND NR3C1 OR6V1 TAS2R39 OR9P1P KEL LLCFC1 TRPV5 TMEM139 TCAF2 GSTK1 PIP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCAF2 on UCSC Golden Path with GeneCards custom track

Promoters for TCAF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000328844 50 2001 PKNOX1
ENSR00000219410 1350 201

Genomic Locations for TCAF2 Gene

Genomic Locations for TCAF2 Gene
109,460 bases
Plus strand

Genomic View for TCAF2 Gene

Genes around TCAF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCAF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCAF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCAF2 Gene

Proteins for TCAF2 Gene

  • Protein details for TCAF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TRPM8 channel-associated factor 2
    Protein Accession:
    Secondary Accessions:
    • B4DK02
    • Q14D25
    • Q17RQ4
    • Q8IWQ0
    • Q8NF84

    Protein attributes for TCAF2 Gene

    919 amino acids
    Molecular mass:
    100906 Da
    Quaternary structure:
    • Isoform 2 interacts with TRPM8 (via N-terminus and C-terminus domains); the interaction inhibits TRPM8 channel activity. Interacts with TRPV6.
    • Sequence=BAC03376.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TCAF2 Gene


neXtProt entry for TCAF2 Gene

Post-translational modifications for TCAF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCAF2 Gene

Domains & Families for TCAF2 Gene

Gene Families for TCAF2 Gene

Protein Domains for TCAF2 Gene

Suggested Antigen Peptide Sequences for TCAF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TCAF family.
  • Belongs to the TCAF family.
genes like me logo Genes that share domains with TCAF2: view

Function for TCAF2 Gene

Molecular function for TCAF2 Gene

UniProtKB/Swiss-Prot Function:
Isoform 2: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner.

Phenotypes From GWAS Catalog for TCAF2 Gene

Gene Ontology (GO) - Molecular Function for TCAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044325 ion channel binding IPI 25559186
genes like me logo Genes that share ontologies with TCAF2: view
genes like me logo Genes that share phenotypes with TCAF2: view

Animal Model Products

CRISPR Products

miRNA for TCAF2 Gene

miRTarBase miRNAs that target TCAF2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCAF2 Gene

Localization for TCAF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCAF2 Gene

Isoform 2: Cell membrane. Note=Colocalizes with TRPM8 on the plasma membrane. {ECO:0000269 PubMed:25559186}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCAF2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Plasma membrane (3)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 25559186
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TCAF2: view

Pathways & Interactions for TCAF2 Gene

SuperPathways for TCAF2 Gene

No Data Available

Interacting Proteins for TCAF2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: A6NFQ2-TCAF2_HUMAN ENSP00000349902 for TCAF2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TCAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0010360 negative regulation of anion channel activity IDA 25559186
GO:0030335 positive regulation of cell migration IDA 25559186
GO:0090314 positive regulation of protein targeting to membrane IMP 25559186
genes like me logo Genes that share ontologies with TCAF2: view

No data available for Pathways by source and SIGNOR curated interactions for TCAF2 Gene

Drugs & Compounds for TCAF2 Gene

No Compound Related Data Available

Transcripts for TCAF2 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCAF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c
SP1: -
SP2: -

Relevant External Links for TCAF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCAF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCAF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TCAF2 Gene

This gene is overexpressed in Cervix (36.2), Lymph node (7.8), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCAF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCAF2 Gene:


mRNA Expression by UniProt/SwissProt for TCAF2 Gene:

Tissue specificity: Isoform 2 is expressed in the prostate and in cancerous prostate samples.

Evidence on tissue expression from TISSUES for TCAF2 Gene

  • Spleen(4.1)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with TCAF2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCAF2 Gene

Orthologs for TCAF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCAF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM115C 34 33
  • 98.82 (n)
(Canis familiaris)
Mammalia FAM115C 34 33
  • 83.33 (n)
(Bos Taurus)
Mammalia FAM115C 33 34
  • 82.03 (n)
(Mus musculus)
Mammalia Fam115c 34 33
  • 79.27 (n)
Tcaf2 16
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 56 (a)
-- 34
  • 55 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam115c 33
  • 54.59 (n)
Str.16417 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1616 33
(Danio rerio)
Actinopterygii zgc:162193 33 34
  • 49.82 (n)
si:ch211-210b2.2 34
  • 36 (a)
si:ch211-210b2.3 34
  • 36 (a)
si:ch211-210b2.4 34
  • 36 (a)
Species where no ortholog for TCAF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCAF2 Gene

Gene Tree for TCAF2 (if available)
Gene Tree for TCAF2 (if available)

Paralogs for TCAF2 Gene

Paralogs for TCAF2 Gene

genes like me logo Genes that share paralogs with TCAF2: view

Variants for TCAF2 Gene

Sequence variations from dbSNP and Humsavar for TCAF2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000196077 -- 143,730,658(+) CACAC(A/C)CACAC utr-variant-3-prime
rs1000197200 -- 143,632,485(+) ATCAA(C/T)AAATA intron-variant
rs1000252547 -- 143,727,188(+) GAGCA(-/C)CCCCA intron-variant
rs1000275212 -- 143,701,836(+) TTGAG(A/G)CAGAG intron-variant, upstream-variant-2KB
rs1000283750 -- 143,725,905(+) GCATC(C/G)GTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCAF2 Gene

Variant ID Type Subtype PubMed ID
esv2422489 CNV duplication 17116639
esv2759570 CNV gain+loss 17122850
esv2761113 CNV gain+loss 21179565
esv2761375 CNV gain 21179565
esv29816 CNV gain+loss 19812545
esv3572224 CNV loss 25503493
esv3584556 CNV gain 24956385
esv3615306 CNV loss 21293372
esv3615307 CNV gain 21293372
dgv6710n100 CNV loss 25217958
dgv6709n100 CNV loss 25217958
dgv6708n100 CNV loss 25217958
dgv6707n100 CNV loss 25217958
dgv6706n100 CNV loss 25217958
dgv6705n100 CNV gain+loss 25217958
dgv6704n100 CNV loss 25217958
dgv6703n100 CNV loss 25217958
dgv6702n100 CNV gain 25217958
dgv6701n100 CNV gain 25217958
dgv6700n100 CNV gain 25217958
dgv6699n100 CNV gain 25217958
dgv249n111 CNV duplication 26073780
dgv12n29 CNV gain+loss 16826518
nsv824356 CNV loss 20364138
nsv8227 CNV gain+loss 18304495
nsv819199 CNV gain 19587683
nsv818565 CNV gain 17921354
nsv7408 OTHER inversion 18451855
nsv608686 CNV loss 21841781
nsv608685 CNV loss 21841781
nsv608684 CNV loss 21841781
nsv608683 CNV loss 21841781
nsv608682 CNV gain 21841781
nsv522225 CNV gain 19592680
nsv520055 CNV loss 19592680
nsv514455 CNV gain+loss 21397061
nsv442210 CNV gain 18776908
nsv428188 CNV gain+loss 18775914
nsv16 OTHER inversion 15895083
nsv1161631 CNV duplication 26073780
nsv1152507 CNV duplication 26484159
nsv1152402 CNV duplication 26484159
nsv1151212 CNV duplication 26484159
nsv1150104 CNV duplication 26484159
nsv1145165 CNV deletion 24896259
nsv1144202 CNV deletion 24896259
nsv1144201 CNV deletion 24896259
nsv1140255 OTHER inversion 24896259
nsv1133673 CNV deletion 24896259
nsv1126813 CNV deletion 24896259
nsv1076007 CNV deletion 25765185
nsv1034865 CNV gain 25217958
nsv1033465 CNV gain 25217958
nsv1029557 CNV gain+loss 25217958
nsv1024360 CNV gain+loss 25217958
nsv1022655 CNV gain 25217958
nsv1022654 CNV gain+loss 25217958
nsv1020659 CNV gain+loss 25217958
nsv1017272 CNV gain 25217958
nsv1016831 CNV gain 25217958
esv3891222 CNV gain+loss 25118596
esv3891221 CNV loss 25118596
esv3891219 CNV loss 25118596

Variation tolerance for TCAF2 Gene

Gene Damage Index Score: 1.50; 29.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCAF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCAF2 Gene

Disorders for TCAF2 Gene

Relevant External Links for TCAF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TCAF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCAF2 Gene

Publications for TCAF2 Gene

  1. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. (PMID: 25559186) Gkika D … Prevarskaya N (The Journal of cell biology 2015) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J … Elledge SJ (Cell 2009) 3 60

Products for TCAF2 Gene

Sources for TCAF2 Gene

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