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Aliases for TCAF1 Gene

Aliases for TCAF1 Gene

  • TRPM8 Channel Associated Factor 1 2 3
  • Family With Sequence Similarity 115, Member A 2 3
  • TRPM8 Channel-Associated Factor 1 2 5
  • TRP Channel-Associated Factor 1 3 4
  • FAM115A 3 4
  • Protein FAM115A 3
  • KIAA0738 4

External Ids for TCAF1 Gene

Previous HGNC Symbols for TCAF1 Gene

  • FAM115A

Summaries for TCAF1 Gene

GeneCards Summary for TCAF1 Gene

TCAF1 (TRPM8 Channel Associated Factor 1) is a Protein Coding gene. GO annotations related to this gene include ion channel binding. An important paralog of this gene is TCAF2.

UniProtKB/Swiss-Prot for TCAF1 Gene

  • Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCAF1 Gene

Genomics for TCAF1 Gene

Regulatory Elements for TCAF1 Gene

Enhancers for TCAF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TCAF1 on UCSC Golden Path with GeneCards custom track

Promoters for TCAF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCAF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCAF1 Gene

143,851,368 bp from pter
143,902,198 bp from pter
50,831 bases
Minus strand

Genomic View for TCAF1 Gene

Genes around TCAF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCAF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCAF1 Gene

Proteins for TCAF1 Gene

  • Protein details for TCAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TRPM8 channel-associated factor 1
    Protein Accession:
    Secondary Accessions:
    • A8K6E0
    • Q75KM8
    • Q75KM9
    • Q7L665
    • Q9BW63

    Protein attributes for TCAF1 Gene

    921 amino acids
    Molecular mass:
    102126 Da
    Quaternary structure:
    • Interacts with TRPM8 (via N-terminus and C-terminus domains); the interaction inhibits TRPM8 channel activity. Interacts with TRPV6.
    • Sequence=BAA34458.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TCAF1 Gene


neXtProt entry for TCAF1 Gene

Proteomics data for TCAF1 Gene at MOPED

Post-translational modifications for TCAF1 Gene

  • Ubiquitination at Lys 274, Lys 281, Lys 434, Lys 439, Lys 632, Lys 750, Lys 817, Lys 865, and Lys 912
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TCAF1 Gene

Domains & Families for TCAF1 Gene

Protein Domains for TCAF1 Gene

Suggested Antigen Peptide Sequences for TCAF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The C-terminal region is necessary for the channel activity stimulation.
  • Belongs to the TCAF family.
  • The C-terminal region is necessary for the channel activity stimulation.
  • Contains 1 peptidase M60 domain.
  • Belongs to the TCAF family.
genes like me logo Genes that share domains with TCAF1: view

No data available for Gene Families for TCAF1 Gene

Function for TCAF1 Gene

Molecular function for TCAF1 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner.
genes like me logo Genes that share phenotypes with TCAF1: view

Animal Model Products

miRNA for TCAF1 Gene

miRTarBase miRNAs that target TCAF1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCAF1 Gene

Localization for TCAF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCAF1 Gene

Cell membrane. Note=Colocalizes with TRPM8 on the plasma membrane. {ECO:0000269 PubMed:25559186}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TCAF1 Gene

Pathways & Interactions for TCAF1 Gene

SuperPathways for TCAF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with TCAF1: view

No data available for Pathways by source and SIGNOR curated interactions for TCAF1 Gene

Drugs & Compounds for TCAF1 Gene

No Compound Related Data Available

Transcripts for TCAF1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TCAF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b
SP1: - - - - -
SP2: - - - - -
SP3: - -
SP6: - - -
SP7: -
SP8: - - - - - -

Relevant External Links for TCAF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCAF1 Gene

mRNA expression in normal human tissues for TCAF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TCAF1 Gene

This gene is overexpressed in Breast (14.6) and Testis (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCAF1 Gene

mRNA Expression by UniProt/SwissProt for TCAF1 Gene

Tissue specificity: Isoform 2 is expressed in the prostate and strongly expressed in cancerous prostate samples.
genes like me logo Genes that share expression patterns with TCAF1: view

Protein tissue co-expression partners for TCAF1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for TCAF1 Gene

Orthologs for TCAF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCAF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM115A 35
  • 89.32 (n)
  • 97.61 (a)
FAM115A 36
  • 98 (a)
(Canis familiaris)
Mammalia LOC482730 35
  • 90.88 (n)
  • 98.15 (a)
FAM115A 36
  • 98 (a)
(Mus musculus)
Mammalia Fam115a 35
  • 86.51 (n)
  • 90.53 (a)
Tcaf1 16
Fam115a 36
  • 90 (a)
(Pan troglodytes)
Mammalia FAM115A 35
  • 99.67 (n)
  • 99.78 (a)
FAM115A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam115a 35
  • 86.54 (n)
  • 90.64 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
-- 36
  • 56 (a)
-- 36
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
-- 36
  • 44 (a)
(Danio rerio)
Actinopterygii si:ch211-210b2.2 36
  • 37 (a)
si:ch211-210b2.3 36
  • 37 (a)
si:ch211-210b2.4 36
  • 38 (a)
zgc:162193 36
  • 38 (a)
Species with no ortholog for TCAF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCAF1 Gene

Gene Tree for TCAF1 (if available)
Gene Tree for TCAF1 (if available)

Paralogs for TCAF1 Gene

Paralogs for TCAF1 Gene Pseudogenes for TCAF1 Gene

genes like me logo Genes that share paralogs with TCAF1: view

Variants for TCAF1 Gene

Sequence variations from dbSNP and Humsavar for TCAF1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6961160 -- 143,883,147(+) TATTA(C/T)TCAGT intron-variant, upstream-variant-2KB
rs12671703 -- 143,882,181(+) GCTCC(C/T)CCATG intron-variant
rs13240033 -- 143,882,674(+) CCCAG(C/G)CCGAG intron-variant
rs2051849 -- 143,902,764(+) tagag(A/G)caggg upstream-variant-2KB
rs7784645 -- 143,903,920(+) cccac(C/T)cccat upstream-variant-2KB

Variation tolerance for TCAF1 Gene

Gene Damage Index Score: 1.62; 31.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TCAF1 Gene

Disorders for TCAF1 Gene

Relevant External Links for TCAF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TCAF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCAF1 Gene

Publications for TCAF1 Gene

  1. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. (PMID: 25559186) Gkika D. … Prevarskaya N. (J. Cell Biol. 2015) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Identification of new mechanisms of cellular response to chemotherapy by tracking changes in post-translational modifications by ubiquitin and ubiquitin-like proteins. (PMID: 24654937) Bonacci T. … Soubeyran P. (J. Proteome Res. 2014) 3

Products for TCAF1 Gene

Sources for TCAF1 Gene