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Aliases for TCAF1 Gene

Aliases for TCAF1 Gene

  • TRPM8 Channel-Associated Factor 1 2 3
  • Family With Sequence Similarity 115, Member A 2 3
  • TRP Channel-Associated Factor 1 3 4
  • FAM115A 3 4
  • Protein FAM115A 3
  • KIAA0738 4

External Ids for TCAF1 Gene

Previous Symbols for TCAF1 Gene

  • FAM115A

Summaries for TCAF1 Gene

GeneCards Summary for TCAF1 Gene

TCAF1 (TRPM8 Channel-Associated Factor 1) is a Protein Coding gene. An important paralog of this gene is TCAF2.

UniProtKB/Swiss-Prot for TCAF1 Gene

  • Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCAF1 Gene

Genomics for TCAF1 Gene

Genomic Location for TCAF1 Gene

143,851,368 bp from pter
143,902,198 bp from pter
50,831 bases
Minus strand

Genomic View for TCAF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCAF1 Gene

No data available for Regulatory Elements for TCAF1 Gene

Proteins for TCAF1 Gene

  • Protein details for TCAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TRPM8 channel-associated factor 1
    Protein Accession:
    Secondary Accessions:
    • A8K6E0
    • Q75KM8
    • Q75KM9
    • Q7L665
    • Q9BW63

    Protein attributes for TCAF1 Gene

    921 amino acids
    Molecular mass:
    102126 Da
    Quaternary structure:
    • Interacts with TRPM8 (via N-terminus and C-terminus domains); the interaction inhibits TRPM8 channel activity. Interacts with TRPV6.
    • Sequence=BAA34458.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TCAF1 Gene


neXtProt entry for TCAF1 Gene

Proteomics data for TCAF1 Gene at MOPED

Post-translational modifications for TCAF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCAF1 Gene

Domains for TCAF1 Gene

Protein Domains for TCAF1 Gene


Graphical View of Domain Structure for InterPro Entry



  • The C-terminal region is necessary for the channel activity stimulation.:
    • Q9Y4C2
  • Contains 1 peptidase M60 domain.:
    • Q9Y4C2
  • Belongs to the TCAF family.:
    • Q9Y4C2
genes like me logo Genes that share domains with TCAF1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TCAF1 Gene

Function for TCAF1 Gene

Molecular function for TCAF1 Gene

UniProtKB/Swiss-Prot Function: Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner.

Gene Ontology (GO) - Molecular Function for TCAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0044325 ion channel binding IPI 25559186
genes like me logo Genes that share ontologies with TCAF1: view

miRNA for TCAF1 Gene

miRTarBase miRNAs that target TCAF1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TCAF1 Gene

Localization for TCAF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCAF1 Gene

Cell membrane. Note=Colocalizes with TRPM8 on the plasma membrane. {ECO:0000269 PubMed:25559186}.

Gene Ontology (GO) - Cellular Components for TCAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 25559186
genes like me logo Genes that share ontologies with TCAF1: view

No data available for Subcellular locations from COMPARTMENTS for TCAF1 Gene

Pathways for TCAF1 Gene

SuperPathways for TCAF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0030336 negative regulation of cell migration IDA 25559186
GO:0090314 positive regulation of protein targeting to membrane IMP 25559186
GO:1901529 positive regulation of anion channel activity IDA 25559186
genes like me logo Genes that share ontologies with TCAF1: view

No data available for Pathways by source for TCAF1 Gene

Transcripts for TCAF1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TCAF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b
SP1: - - - - -
SP2: - - - - -
SP3: - -
SP6: - - -
SP7: -
SP8: - - - - - -

Relevant External Links for TCAF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCAF1 Gene

mRNA expression in normal human tissues for TCAF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TCAF1 Gene

mRNA Expression by UniProt/SwissProt for TCAF1 Gene

Tissue specificity: Isoform 2 is expressed in the prostate and strongly expressed in cancerous prostate samples.
genes like me logo Genes that share expressions with TCAF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TCAF1 Gene

Orthologs for TCAF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCAF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM115A 35
  • 99.67 (n)
  • 99.78 (a)
FAM115A 36
  • 100 (a)
(Bos Taurus)
Mammalia FAM115A 35
  • 89.32 (n)
  • 97.61 (a)
FAM115A 36
  • 98 (a)
(Canis familiaris)
Mammalia FAM115A 36
  • 98 (a)
LOC482730 35
  • 90.88 (n)
  • 98.15 (a)
(Mus musculus)
Mammalia Fam115a 35
  • 86.51 (n)
  • 90.53 (a)
Fam115a 16
Fam115a 36
  • 90 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
-- 36
  • 56 (a)
-- 36
  • 48 (a)
(Rattus norvegicus)
Mammalia Fam115a 35
  • 86.54 (n)
  • 90.64 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
-- 36
  • 44 (a)
(Danio rerio)
Actinopterygii si:ch211-210b2.2 36
  • 37 (a)
si:ch211-210b2.3 36
  • 37 (a)
si:ch211-210b2.4 36
  • 38 (a)
zgc:162193 36
  • 38 (a)
Species with no ortholog for TCAF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCAF1 Gene

Gene Tree for TCAF1 (if available)
Gene Tree for TCAF1 (if available)

Paralogs for TCAF1 Gene

Paralogs for TCAF1 Gene Pseudogenes for TCAF1 Gene

genes like me logo Genes that share paralogs with TCAF1: view

Variants for TCAF1 Gene

Sequence variations from dbSNP and Humsavar for TCAF1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2051849 -- 143,902,764(+) tagag(A/G)caggg upstream-variant-2KB
rs2107593 -- 143,885,901(+) ACACG(C/T)ATTAT intron-variant, upstream-variant-2KB
rs3735381 -- 143,902,104(+) CCCAG(A/G)AGGAA utr-variant-5-prime, upstream-variant-2KB
rs3735382 -- 143,902,138(+) AAGGG(C/G)AGCGG utr-variant-5-prime, upstream-variant-2KB
rs3735383 -- 143,902,154(+) AAACT(A/G)CAGGA utr-variant-5-prime, upstream-variant-2KB

Relevant External Links for TCAF1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCAF1 Gene

Disorders for TCAF1 Gene

No disorders were found for TCAF1 Gene.

No data available for UniProtKB/Swiss-Prot for TCAF1 Gene

Publications for TCAF1 Gene

  1. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. (PMID: 25559186) Gkika D. … Prevarskaya N. (J. Cell Biol. 2015) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Lineage-specific gene duplication and loss in human and great ape evolution. (PMID: 15252450) Fortna A. … Sikela J.M. (PLoS Biol. 2004) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for TCAF1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TCAF1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TCAF1
    • Block miRNA regulation of TCAF1 using miScript Target Protectors

    Sources for TCAF1 Gene

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