Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TC2N Gene

Aliases for TC2N Gene

  • Tandem C2 Domains, Nuclear 2 3
  • Membrane Targeting (Tandem) C2 Domain Containing 1 2 3
  • C2 Calcium-Dependent Domain Containing 1 2 3
  • Tandem C2 Protein In Nucleus 3 4
  • C14orf47 3 4
  • MTAC2D1 3 4
  • Tac2-N 3 4
  • Membrane Targeting Tandem C2 Domain-Containing Protein 1 4
  • Chromosome 14 Open Reading Frame 47 2
  • C2CD1 3

External Ids for TC2N Gene

Previous HGNC Symbols for TC2N Gene

  • C14orf47
  • MTAC2D1

Previous GeneCards Identifiers for TC2N Gene

  • GC14M091317
  • GC14M092246
  • GC14M072426

Summaries for TC2N Gene

GeneCards Summary for TC2N Gene

TC2N (Tandem C2 Domains, Nuclear) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding.

Gene Wiki entry for TC2N Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TC2N Gene

Genomics for TC2N Gene

Regulatory Elements for TC2N Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TC2N Gene

Chromosome:
14
Start:
91,779,751 bp from pter
End:
91,867,536 bp from pter
Size:
87,786 bases
Orientation:
Minus strand

Genomic View for TC2N Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TC2N Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TC2N Gene

Proteins for TC2N Gene

  • Protein details for TC2N Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9U0-TAC2N_HUMAN
    Recommended name:
    Tandem C2 domains nuclear protein
    Protein Accession:
    Q8N9U0

    Protein attributes for TC2N Gene

    Size:
    490 amino acids
    Molecular mass:
    55284 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TC2N Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TC2N Gene

Proteomics data for TC2N Gene at MOPED

Post-translational modifications for TC2N Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TC2N Gene

Domains & Families for TC2N Gene

Gene Families for TC2N Gene

Protein Domains for TC2N Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TC2N Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N9U0

UniProtKB/Swiss-Prot:

TAC2N_HUMAN :
  • Contains 1 C2 domain.
Domain:
  • Contains 1 C2 domain.
genes like me logo Genes that share domains with TC2N: view

Function for TC2N Gene

Gene Ontology (GO) - Molecular Function for TC2N Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding --
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0019905 NOT syntaxin binding IBA --
genes like me logo Genes that share ontologies with TC2N: view

Phenotypes for TC2N Gene

genes like me logo Genes that share phenotypes with TC2N: view

Animal Model Products

miRNA for TC2N Gene

miRTarBase miRNAs that target TC2N

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TC2N

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TC2N Gene

Localization for TC2N Gene

Subcellular locations from UniProtKB/Swiss-Prot for TC2N Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TC2N Gene COMPARTMENTS Subcellular localization image for TC2N gene
Compartment Confidence
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TC2N Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with TC2N: view

Pathways & Interactions for TC2N Gene

SuperPathways for TC2N Gene

No Data Available

Interacting Proteins for TC2N Gene

Gene Ontology (GO) - Biological Process for TC2N Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IMP 21810271
GO:0016079 NOT synaptic vesicle exocytosis IBA --
GO:0017158 NOT regulation of calcium ion-dependent exocytosis IBA --
GO:0030193 regulation of blood coagulation IMP 21810271
GO:0048791 NOT calcium ion-dependent exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with TC2N: view

No data available for Pathways by source and SIGNOR curated interactions for TC2N Gene

Drugs & Compounds for TC2N Gene

No Compound Related Data Available

Transcripts for TC2N Gene

Unigene Clusters for TC2N Gene

Tandem C2 domains, nuclear:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TC2N

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TC2N Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - -
SP6: -
SP7:
SP8:

Relevant External Links for TC2N Gene

GeneLoc Exon Structure for
TC2N
ECgene alternative splicing isoforms for
TC2N

Expression for TC2N Gene

mRNA expression in normal human tissues for TC2N Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TC2N Gene

This gene is overexpressed in Pancreas (x8.8), Artery - Aorta (x5.0), and Minor Salivary Gland (x4.2).

Protein differential expression in normal tissues from HIPED for TC2N Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.5), Pancreas (17.2), and Lung (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TC2N Gene



SOURCE GeneReport for Unigene cluster for TC2N Gene Hs.510262

genes like me logo Genes that share expression patterns with TC2N: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TC2N Gene

Orthologs for TC2N Gene

This gene was present in the common ancestor of chordates.

Orthologs for TC2N Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TC2N 35
  • 92.04 (n)
  • 91.22 (a)
TC2N 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TC2N 35
  • 89.73 (n)
  • 89.39 (a)
TC2N 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tc2n 35
  • 88.82 (n)
  • 87.73 (a)
Tc2n 16
Tc2n 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TC2N 35
  • 99.39 (n)
  • 99.18 (a)
TC2N 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tc2n 35
  • 88.62 (n)
  • 86.91 (a)
oppossum
(Monodelphis domestica)
Mammalia TC2N 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TC2N 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TC2N 35
  • 70.82 (n)
  • 68.3 (a)
TC2N 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TC2N 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tc2n 35
  • 65.49 (n)
  • 63.2 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101885722 35
  • 52.79 (n)
  • 47.64 (a)
TC2N 36
  • 43 (a)
OneToOne
Species with no ortholog for TC2N:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TC2N Gene

ENSEMBL:
Gene Tree for TC2N (if available)
TreeFam:
Gene Tree for TC2N (if available)

Paralogs for TC2N Gene

Pseudogenes.org Pseudogenes for TC2N Gene

genes like me logo Genes that share paralogs with TC2N: view

No data available for Paralogs for TC2N Gene

Variants for TC2N Gene

Sequence variations from dbSNP and Humsavar for TC2N Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs733009 -- 91,855,176(+) AGGTT(C/T)GCTTC intron-variant
rs759232 -- 91,857,566(+) AACTG(A/G)AGCCG intron-variant
rs878566 -- 91,858,271(+) ACAGG(C/T)GTGAG intron-variant
rs887896 -- 91,857,014(+) AGAGC(A/G)CTAGA intron-variant
rs1548817 -- 91,866,524(+) ACCCA(C/T)ATGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TC2N Gene

Variant ID Type Subtype PubMed ID
esv272067 CNV Insertion 20981092

Variation tolerance for TC2N Gene

Residual Variation Intolerance Score: 34.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TC2N Gene

HapMap Linkage Disequilibrium report
TC2N

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TC2N Gene

Disorders for TC2N Gene

Relevant External Links for TC2N

Genetic Association Database (GAD)
TC2N
Human Genome Epidemiology (HuGE) Navigator
TC2N
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TC2N
genes like me logo Genes that share disorders with TC2N: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TC2N Gene

Publications for TC2N Gene

  1. Tac2-N, an atypical C-type tandem C2 protein localized in the nucleus. (PMID: 11526914) Fukuda M. … Mikoshiba K. (FEBS Lett. 2001) 2 67
  2. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 67
  3. Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. (PMID: 21810271) Antoni G. … Tregouet D.A. (BMC Med. Genet. 2011) 67
  4. Impact on venous thrombosis risk of newly discovered gene variants associated with FVIII and VWF plasma levels. (PMID: 21029358) Morange P.E. … TrAcgouAt D.A. (J. Thromb. Haemost. 2011) 67
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 67

Products for TC2N Gene

Sources for TC2N Gene

Back to Top

Content