TC2N Gene
protein-coding GIFtS: 45
GCID: GC14M092246
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|
tandem C2 domains, nuclear(Previous names: chromosome 14 open reading frame 47, membrane targeting...)
(Previous symbols: C14orf47, MTAC2D1)
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Aliases
for TC2N gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tandem C2 Domains, Nuclear1 2 | | Membrane Targeting Tandem C2 Domain-Containing Protein 12 3 | | C14orf471 2 3 | | Tandem C2 Protein In Nucleus2 3 | | MTAC2D11 2 3 | | FLJ365571 | | Tac2-N1 2 3 | | Chromosome 14 Open Reading Frame 471 | | C2CD11 2 | | C2 Calcium-Dependent Domain Containing 12 | | Membrane Targeting (Tandem) C2 Domain Containing 11 2 | | Tandem C2 Domains Nuclear Protein2 |
Export aliases for TC2N gene to outside databasesPrevious GC identifers: GC14M091317 GC14M072426 |
Summaries
for TC2N gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for TC2N
|
Genomic Views
for TC2N gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TC2N gene promoter:
STAT5B STAT1 AML1a Pbx1a C/EBPalpha Gfi-1 POU2F1 FOXO4 POU2F1a HSF2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TC2N
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TC2N |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.12 Ensembl cytogenetic band: 14q32.12 HGNC cytogenetic band: 14q32.12TC2N Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M092246: view genomic region
(about GC identifiers)
Start:
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92,246,095 bp from pter |
End:
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92,333,880 bp from pter |
Size:
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87,786 bases |
Orientation:
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minus strand |
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Proteins
for TC2N gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAC2N_HUMAN, Q8N9U0 (See
protein sequence)Recommended Name: Tandem C2 domains nuclear protein Size: 490 amino acids; 55284 Da
Subcellular location: Nucleus (By similarity)Alternative splicing: 2 isoforms: Q8N9U0-1 Q8N9U0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TC2N: NX_Q8N9U0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N9U0
TC2N Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001122067.1 NP_001122068.1 NP_689545.1
ENSEMBL proteins: ENSP00000387882 ENSP00000343199 ENSP00000353802 ENSP00000451317 ENSP00000450922
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
TC2N for ontologies About GeneDecksing
TC2N Antibody Products:
Assay Products for TC2N: |
Protein
Domains /
Families
for TC2N gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TC2N for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N9U0ProtoNet protein and cluster: Q8N9U0 1 Blocks protein family: IPB000008 C2 domain
UniProtKB/Swiss-Prot: TAC2N_HUMAN, Q8N9U0Similarity: Contains 1 C2 domain |
Function
for TC2N gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TC2N (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TC2N (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): TC2N (NM_152332) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TC2N | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TC2N |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TC2N |
1 GenomeRNAi human phenotype for TC2N:
|
Pathways & Interactions
for TC2N gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TC2N
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TC2N (ENSP000003431994) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TC2N gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TC2N
Search CenterWatch for drugs/clinical trials and news about TC2N / TAC2N
|
Transcripts
for TC2N gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TC2N gene (3 alternative transcripts): NM_001128595.1 NM_001128596.1 NM_152332.4 Unigene Cluster for TC2N: Tandem C2 domains, nuclear Hs.510262 [show with all ESTs]Unigene Representative Sequence: NM_1523327 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000435962(uc001xzu.4 uc010auc.3 uc001xzv.4) ENST00000340892(uc001xzt.4)
ENST00000360594 ENST00000556018 ENST00000556590 ENST00000554424 ENST00000555302
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TC2N (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TC2N (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TC2N (NM_152332) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TC2N | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TC2N |
Additional cDNA sequence: AK093876.1 AK126359.1 BC040503.1 BX647828.1 BX648227.1 6 DOTS entries: DT.312954 DT.100775358 DT.101982736 DT.100775360 DT.40202222 DT.99973345 24/168 AceView cDNA sequences (see all 168): AI910436 BQ421151 BM023130 AI741162 AW605686 AA909391 AA360896 CB153880 AA075405 AA361684 BU676496 BM840272 BE302146 AA578758 BM021374 AW294294 AI351894 BE928672 NM_024764 AA456598 AI470643 AI151308 AA314397 BQ778292
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TC2N (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | · | 15d |
|---|
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| SP1: | | | | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TC2N
|
Expression
for TC2N gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TC2N expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TC2N Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TC2N
SOURCE GeneReport for Unigene cluster: Hs.510262
SABiosciences Custom PCR Arrays for TC2N
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TC2N
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TC2N | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TC2N | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TC2N | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TC2N |
Orthologs
for TC2N gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TC2N gene from 5/11 species (see all 11) About this table
ENSEMBL Gene Tree for TC2N (if available)
TreeFam Gene Tree for TC2N (if available) |
Paralogs
for TC2N gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TC2N gene
TC2N for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for TC2N
PGOHUM00000237234 PGOHUM00000237291
|
Genomic Variants
for TC2N gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TC2N (92246095 - 92333880 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TC2N: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TC2N gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TC2N for disorders About GeneDecksing
2  diseases for TC2N: About MalaCardsthrombosis venous thrombosis
Human Genome Epidemiology (HuGE) Navigator: TC2N (1 document)
Export disorders for TC2N gene to outside databases
|
Publications
for TC2N gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TC2N gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TC2N) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Tac2-N, an atypical C-type tandem C2 protein localized in the nucleus. (PubMed id 11526914)1, 3 Fukuda M. and Mikoshiba K. (2001)
- Impact on venous thrombosis risk of newly discovered gene variants associated with FVIII and VWF plasma levels. (PubMed id 21029358)1 Morange P.E....TrAcgouAt D.A. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (2008)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
|
External Searches for TC2N gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TC2N gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TC2N gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TC2N gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TC2N | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TC2N gene:
Search GeneIP for patents involving TC2N
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TC2N gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TC2N | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TC2N | | | OriGene Protein Over-expression Lysate for TC2N | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TC2N | | OriGene 3'-UTR Clone for TC2N | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TC2N | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TC2N | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TC2N | | OriGene Custom Protein Services for TC2N | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TC2N | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TC2N | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TC2N | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TC2N | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TC2N | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TC2N |
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| | | | Search Tocris compounds for TC2N |
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 | | | TC2N Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TC2N |
|  |  |  | | | | ThermoFisher Antibodies for TC2N |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TC2N |
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