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Aliases for TC2N Gene

Aliases for TC2N Gene

  • Tandem C2 Domains, Nuclear 2 3 5
  • Membrane Targeting (Tandem) C2 Domain Containing 1 2 3
  • C2 Calcium-Dependent Domain Containing 1 2 3
  • Tandem C2 Protein In Nucleus 3 4
  • C14orf47 3 4
  • MTAC2D1 3 4
  • Tac2-N 3 4
  • Membrane Targeting Tandem C2 Domain-Containing Protein 1 4
  • Chromosome 14 Open Reading Frame 47 2
  • Tandem C2 Domains Nuclear Protein 3
  • C2CD1 3

External Ids for TC2N Gene

Previous HGNC Symbols for TC2N Gene

  • C14orf47
  • MTAC2D1

Previous GeneCards Identifiers for TC2N Gene

  • GC14M091317
  • GC14M092246
  • GC14M072426
  • GC14M091780

Summaries for TC2N Gene

GeneCards Summary for TC2N Gene

TC2N (Tandem C2 Domains, Nuclear) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding.

Gene Wiki entry for TC2N Gene

Additional gene information for TC2N Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TC2N Gene

Genomics for TC2N Gene

Regulatory Elements for TC2N Gene

Enhancers for TC2N Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H091830 1 Ensembl ENCODE 60 +36.5 36525 1 ZNF146 KLF1 FOXA2 ZBTB21 BATF ZBTB48 PRDM10 RUNX3 SCRT1 JUNB TC2N FBLN5 TRIP11 CATSPERB GC14M091805
GH14H091753 1.1 Ensembl ENCODE 48.1 +112.1 112061 4 ELF3 PKNOX1 FOXA2 ARID4B KLF17 BRCA1 RARA FOS RCOR1 CREM TC2N CATSPERB PPP4R3A ATXN3 ENSG00000260711 ENSG00000275154 GC14M091834
GH14H091835 0.9 ENCODE 46.9 +30.9 30904 2 SIN3A ZEB1 GLIS2 EGR1 ZSCAN5C RUNX3 IKZF2 EGR2 SP3 REST TC2N CATSPERB GC14M091805
GH14H091743 0.9 ENCODE 37 +123.3 123300 2 PKNOX1 FOXA2 ATF1 INSM2 KLF17 ZNF366 FOS EGR2 YY2 ZNF843 TC2N CATSPERB TRIP11 PPP4R3A FBLN5 ENSG00000260711 ENSG00000275154 GC14M091834
GH14H091831 0.7 ENCODE 41.2 +37.9 37855 0 SMARCA5 SMARCE1 PKNOX1 ELF1 DPF2 FOXA1 ZNF217 CTBP1 PRDM6 GATA3 TC2N CATSPERB FBLN5 TRIP11 GC14M091805
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TC2N on UCSC Golden Path with GeneCards custom track

Genomic Location for TC2N Gene

Chromosome:
14
Start:
91,779,751 bp from pter
End:
91,867,536 bp from pter
Size:
87,786 bases
Orientation:
Minus strand

Genomic View for TC2N Gene

Genes around TC2N on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TC2N Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TC2N Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TC2N Gene

Proteins for TC2N Gene

  • Protein details for TC2N Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9U0-TAC2N_HUMAN
    Recommended name:
    Tandem C2 domains nuclear protein
    Protein Accession:
    Q8N9U0

    Protein attributes for TC2N Gene

    Size:
    490 amino acids
    Molecular mass:
    55284 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TC2N Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TC2N Gene

Post-translational modifications for TC2N Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TC2N Gene

Domains & Families for TC2N Gene

Gene Families for TC2N Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TC2N Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TC2N Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TC2N: view

No data available for UniProtKB/Swiss-Prot for TC2N Gene

Function for TC2N Gene

Phenotypes From GWAS Catalog for TC2N Gene

Gene Ontology (GO) - Molecular Function for TC2N Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005509 NOT calcium ion binding IBA --
GO:0005544 NOT calcium-dependent phospholipid binding IBA --
GO:0019905 NOT syntaxin binding IBA --
GO:0030276 NOT clathrin binding IBA --
genes like me logo Genes that share ontologies with TC2N: view
genes like me logo Genes that share phenotypes with TC2N: view

Animal Model Products

CRISPR Products

miRNA for TC2N Gene

miRTarBase miRNAs that target TC2N

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TC2N
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TC2N Gene

Localization for TC2N Gene

Subcellular locations from UniProtKB/Swiss-Prot for TC2N Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TC2N gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TC2N Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with TC2N: view

Pathways & Interactions for TC2N Gene

No Data Available

Interacting Proteins for TC2N Gene

Gene Ontology (GO) - Biological Process for TC2N Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 NOT vesicle fusion IBA --
GO:0010468 regulation of gene expression IMP 21810271
GO:0017158 NOT regulation of calcium ion-dependent exocytosis IBA --
GO:0030193 regulation of blood coagulation IMP 21810271
GO:0048791 NOT calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with TC2N: view

No data available for Pathways by source and SIGNOR curated interactions for TC2N Gene

Drugs & Compounds for TC2N Gene

No Compound Related Data Available

Transcripts for TC2N Gene

Unigene Clusters for TC2N Gene

Tandem C2 domains, nuclear:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TC2N
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TC2N Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - -
SP6: -
SP7:
SP8:

Relevant External Links for TC2N Gene

GeneLoc Exon Structure for
TC2N
ECgene alternative splicing isoforms for
TC2N

Expression for TC2N Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TC2N Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TC2N Gene

This gene is overexpressed in Pancreas (x8.8), Artery - Aorta (x5.0), and Minor Salivary Gland (x4.2).

Protein differential expression in normal tissues from HIPED for TC2N Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.5), Pancreas (17.2), and Lung (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TC2N Gene



NURSA nuclear receptor signaling pathways regulating expression of TC2N Gene:

TC2N

SOURCE GeneReport for Unigene cluster for TC2N Gene:

Hs.510262

Evidence on tissue expression from TISSUES for TC2N Gene

  • Blood(4.3)
genes like me logo Genes that share expression patterns with TC2N: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TC2N Gene

Orthologs for TC2N Gene

This gene was present in the common ancestor of chordates.

Orthologs for TC2N Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TC2N 33 34
  • 99.39 (n)
cow
(Bos Taurus)
Mammalia TC2N 33 34
  • 92.04 (n)
dog
(Canis familiaris)
Mammalia TC2N 33 34
  • 89.73 (n)
mouse
(Mus musculus)
Mammalia Tc2n 33 16 34
  • 88.82 (n)
rat
(Rattus norvegicus)
Mammalia Tc2n 33
  • 88.62 (n)
oppossum
(Monodelphis domestica)
Mammalia TC2N 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TC2N 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TC2N 33 34
  • 70.82 (n)
lizard
(Anolis carolinensis)
Reptilia TC2N 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tc2n 33
  • 65.49 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101885722 33
  • 52.79 (n)
TC2N 34
  • 43 (a)
OneToOne
Species where no ortholog for TC2N was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TC2N Gene

ENSEMBL:
Gene Tree for TC2N (if available)
TreeFam:
Gene Tree for TC2N (if available)

Paralogs for TC2N Gene

Pseudogenes.org Pseudogenes for TC2N Gene

genes like me logo Genes that share paralogs with TC2N: view

No data available for Paralogs for TC2N Gene

Variants for TC2N Gene

Sequence variations from dbSNP and Humsavar for TC2N Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs886050885 Uncertain significance 91,869,449(-) ATTGG(A/C)ATGCA upstream-variant-2KB, utr-variant-3-prime
rs1000111591 -- 91,866,138(+) CCTTT(A/G)TCAAG intron-variant
rs1000170674 -- 91,830,519(+) GAAAA(C/T)AGATT intron-variant
rs1000209520 -- 91,812,260(+) ATAAT(A/T)GCACT intron-variant
rs1000259271 -- 91,784,006(+) CATTA(G/T)AGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TC2N Gene

Variant ID Type Subtype PubMed ID
esv3307793 CNV mobile element insertion 20981092
esv3406882 CNV insertion 20981092
esv3635327 CNV gain 21293372
nsv1053264 CNV loss 25217958

Variation tolerance for TC2N Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TC2N Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TC2N

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TC2N Gene

Disorders for TC2N Gene

Relevant External Links for TC2N

Genetic Association Database (GAD)
TC2N
Human Genome Epidemiology (HuGE) Navigator
TC2N
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TC2N

No disorders were found for TC2N Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TC2N Gene

Publications for TC2N Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Tac2-N, an atypical C-type tandem C2 protein localized in the nucleus. (PMID: 11526914) Fukuda M … Mikoshiba K (FEBS letters 2001) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard SM … Kanmogne GD (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014) 3 60

Products for TC2N Gene

Sources for TC2N Gene

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